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diff --git a/samtools/misc/md5.h b/samtools/misc/md5.h
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+++ b/samtools/misc/md5.h
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+/*
+  This file is adapted from a program in this page:
+
+  http://www.fourmilab.ch/md5/
+
+  The original source code does not work on 64-bit machines due to the
+  wrong typedef "uint32". I also added prototypes.
+
+  -lh3
+ */
+
+#ifndef MD5_H
+#define MD5_H
+
+/*  The following tests optimise behaviour on little-endian
+    machines, where there is no need to reverse the byte order
+    of 32 bit words in the MD5 computation.  By default,
+    HIGHFIRST is defined, which indicates we're running on a
+    big-endian (most significant byte first) machine, on which
+    the byteReverse function in md5.c must be invoked. However,
+    byteReverse is coded in such a way that it is an identity
+    function when run on a little-endian machine, so calling it
+    on such a platform causes no harm apart from wasting time. 
+    If the platform is known to be little-endian, we speed
+    things up by undefining HIGHFIRST, which defines
+    byteReverse as a null macro.  Doing things in this manner
+    insures we work on new platforms regardless of their byte
+    order.  */
+
+#define HIGHFIRST
+
+#if __LITTLE_ENDIAN__ != 0
+#undef HIGHFIRST
+#endif
+
+#include <stdint.h>
+
+struct MD5Context {
+        uint32_t buf[4];
+        uint32_t bits[2];
+        unsigned char in[64];
+};
+
+void MD5Init(struct MD5Context *ctx);
+void MD5Update(struct MD5Context *ctx, unsigned char *buf, unsigned len);
+void MD5Final(unsigned char digest[16], struct MD5Context *ctx);
+
+/*
+ * This is needed to make RSAREF happy on some MS-DOS compilers.
+ */
+typedef struct MD5Context MD5_CTX;
+
+/*  Define CHECK_HARDWARE_PROPERTIES to have main,c verify
+    byte order and uint32_t settings.  */
+#define CHECK_HARDWARE_PROPERTIES
+
+#endif /* !MD5_H */