Update build dependencies
authorDiane Trout <diane@caltech.edu>
Wed, 14 Dec 2011 01:00:54 +0000 (17:00 -0800)
committerDiane Trout <diane@caltech.edu>
Wed, 14 Dec 2011 01:00:54 +0000 (17:00 -0800)
debian/changelog
debian/control
debian/pysam.substvars [deleted file]
pysam/csamtools.c [deleted file]
pysam/ctabix.c [deleted file]

index 0bcf521a364558136418ef96149da2ba97498d1d..715349096007b9e1108018901f3656474026e936 100644 (file)
@@ -1,3 +1,9 @@
+pysam (0.5-1ubuntu1) oneiric; urgency=low
+
+  * New upstream version
+
+ -- Diane Trout <diane@caltech.edu>  Thu, 21 Jul 2011 14:32:05 -0700
+
 pysam (0.3.1-1) maverick; urgency=low
 
   * Imported Upstream version 0.3.1
@@ -12,6 +18,6 @@ pysam (0.3-1) maverick; urgency=low
 
 pysam (0.2-1~karmic) karmic; urgency=low
 
-  * Initial release 
+  * Initial release
 
  -- Diane Trout <diane@caltech.edu>  Fri, 11 Jun 2010 11:11:41 -0700
index f6061017347a4471b94c36a523bdb47bee088d32..cbb32795b42955aba25c96ed2a535a193112ccf5 100644 (file)
@@ -2,15 +2,15 @@ Source: pysam
 Section: science
 Priority: extra
 Maintainer: Diane Trout <diane@caltech.edu>
-Build-Depends: cdbs, debhelper (>= 7), python-all-dev (>= 2.3.5-11), python-central (>= 0.5.6), python-setuptools (>= 0.6b3), python-pyrex (>= 0.9.8), cython (>= 0.11), zlib1g-dev (>= 1.2.3)
+Build-Depends: cdbs, debhelper (>= 7), python-all-dev (>= 2.3.5-11), python-central (>= 0.5.6), python-setuptools (>= 0.6b3), python-pyrex (>= 0.9.8), cython (>= 0.14), zlib1g-dev (>= 1.2.3)
 Standards-Version: 3.8.4
-XS-Python-Version: >=2.5, <<2.7
-Homepage: http://code.google.com/p/pysam/ 
+XS-Python-Version: >=2.5, <<3.0
+Homepage: http://code.google.com/p/pysam/
 
 Package: python-pysam
 Architecture: any
 Depends: ${python:Depends}, ${shlibs:Depends}, ${misc:Depends}
 XB-Python-Version: ${python:Versions}
 Description: python module for reading and manipulating Samfiles
- Pysam is a python module for reading and manipulating Samfiles. 
+ Pysam is a python module for reading and manipulating Samfiles.
  It's a lightweight wrapper of the samtools C-API.
diff --git a/debian/pysam.substvars b/debian/pysam.substvars
deleted file mode 100644 (file)
index 0fb862c..0000000
+++ /dev/null
@@ -1,4 +0,0 @@
-python:Versions=2.6
-python:Depends=python (<< 2.7), python (>= 2.6), python-central (>= 0.6.11)
-shlibs:Depends=libc6 (>= 2.7), zlib1g (>= 1:1.2.2)
-misc:Depends=
diff --git a/pysam/csamtools.c b/pysam/csamtools.c
deleted file mode 100644 (file)
index 6e18ed6..0000000
+++ /dev/null
@@ -1,39457 +0,0 @@
-/* Generated by Cython 0.13 on Tue Jun  7 17:24:36 2011 */
-
-#define PY_SSIZE_T_CLEAN
-#include "Python.h"
-#ifndef Py_PYTHON_H
-    #error Python headers needed to compile C extensions, please install development version of Python.
-#else
-
-#include <stddef.h> /* For offsetof */
-#ifndef offsetof
-#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
-#endif
-
-#if !defined(WIN32) && !defined(MS_WINDOWS)
-  #ifndef __stdcall
-    #define __stdcall
-  #endif
-  #ifndef __cdecl
-    #define __cdecl
-  #endif
-  #ifndef __fastcall
-    #define __fastcall
-  #endif
-#endif
-
-#ifndef DL_IMPORT
-  #define DL_IMPORT(t) t
-#endif
-#ifndef DL_EXPORT
-  #define DL_EXPORT(t) t
-#endif
-
-#ifndef PY_LONG_LONG
-  #define PY_LONG_LONG LONG_LONG
-#endif
-
-#if PY_VERSION_HEX < 0x02040000
-  #define METH_COEXIST 0
-  #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
-  #define PyDict_Contains(d,o)   PySequence_Contains(d,o)
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  typedef int Py_ssize_t;
-  #define PY_SSIZE_T_MAX INT_MAX
-  #define PY_SSIZE_T_MIN INT_MIN
-  #define PY_FORMAT_SIZE_T ""
-  #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
-  #define PyInt_AsSsize_t(o)   PyInt_AsLong(o)
-  #define PyNumber_Index(o)    PyNumber_Int(o)
-  #define PyIndex_Check(o)     PyNumber_Check(o)
-  #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
-#endif
-
-#if PY_VERSION_HEX < 0x02060000
-  #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
-  #define Py_TYPE(ob)   (((PyObject*)(ob))->ob_type)
-  #define Py_SIZE(ob)   (((PyVarObject*)(ob))->ob_size)
-  #define PyVarObject_HEAD_INIT(type, size) \
-          PyObject_HEAD_INIT(type) size,
-  #define PyType_Modified(t)
-
-  typedef struct {
-     void *buf;
-     PyObject *obj;
-     Py_ssize_t len;
-     Py_ssize_t itemsize;
-     int readonly;
-     int ndim;
-     char *format;
-     Py_ssize_t *shape;
-     Py_ssize_t *strides;
-     Py_ssize_t *suboffsets;
-     void *internal;
-  } Py_buffer;
-
-  #define PyBUF_SIMPLE 0
-  #define PyBUF_WRITABLE 0x0001
-  #define PyBUF_FORMAT 0x0004
-  #define PyBUF_ND 0x0008
-  #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
-  #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
-  #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
-  #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
-  #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
-
-#endif
-
-#if PY_MAJOR_VERSION < 3
-  #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
-#else
-  #define __Pyx_BUILTIN_MODULE_NAME "builtins"
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define Py_TPFLAGS_CHECKTYPES 0
-  #define Py_TPFLAGS_HAVE_INDEX 0
-#endif
-
-#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
-  #define Py_TPFLAGS_HAVE_NEWBUFFER 0
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyBaseString_Type            PyUnicode_Type
-  #define PyStringObject               PyUnicodeObject
-  #define PyString_Type                PyUnicode_Type
-  #define PyString_Check               PyUnicode_Check
-  #define PyString_CheckExact          PyUnicode_CheckExact
-#endif
-
-#if PY_VERSION_HEX < 0x02060000
-  #define PyBytesObject                PyStringObject
-  #define PyBytes_Type                 PyString_Type
-  #define PyBytes_Check                PyString_Check
-  #define PyBytes_CheckExact           PyString_CheckExact
-  #define PyBytes_FromString           PyString_FromString
-  #define PyBytes_FromStringAndSize    PyString_FromStringAndSize
-  #define PyBytes_FromFormat           PyString_FromFormat
-  #define PyBytes_DecodeEscape         PyString_DecodeEscape
-  #define PyBytes_AsString             PyString_AsString
-  #define PyBytes_AsStringAndSize      PyString_AsStringAndSize
-  #define PyBytes_Size                 PyString_Size
-  #define PyBytes_AS_STRING            PyString_AS_STRING
-  #define PyBytes_GET_SIZE             PyString_GET_SIZE
-  #define PyBytes_Repr                 PyString_Repr
-  #define PyBytes_Concat               PyString_Concat
-  #define PyBytes_ConcatAndDel         PyString_ConcatAndDel
-  #define PySet_Check(obj)             PyObject_TypeCheck(obj, &PySet_Type)
-  #define PyFrozenSet_Check(obj)       PyObject_TypeCheck(obj, &PyFrozenSet_Type)
-#endif
-
-#ifndef PySet_CheckExact
-#  define PySet_CheckExact(obj)          (Py_TYPE(obj) == &PySet_Type)
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyInt_Type                   PyLong_Type
-  #define PyInt_Check(op)              PyLong_Check(op)
-  #define PyInt_CheckExact(op)         PyLong_CheckExact(op)
-  #define PyInt_FromString             PyLong_FromString
-  #define PyInt_FromUnicode            PyLong_FromUnicode
-  #define PyInt_FromLong               PyLong_FromLong
-  #define PyInt_FromSize_t             PyLong_FromSize_t
-  #define PyInt_FromSsize_t            PyLong_FromSsize_t
-  #define PyInt_AsLong                 PyLong_AsLong
-  #define PyInt_AS_LONG                PyLong_AS_LONG
-  #define PyInt_AsSsize_t              PyLong_AsSsize_t
-  #define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
-  #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyBoolObject PyLongObject
-#endif
-
-
-#if PY_MAJOR_VERSION >= 3
-  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
-  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
-#else
-  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
-  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),((char *)(n)))
-  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
-  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),((char *)(n)))
-#else
-  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),(n))
-  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
-  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),(n))
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  #define __Pyx_NAMESTR(n) ((char *)(n))
-  #define __Pyx_DOCSTR(n)  ((char *)(n))
-#else
-  #define __Pyx_NAMESTR(n) (n)
-  #define __Pyx_DOCSTR(n)  (n)
-#endif
-
-#ifdef __cplusplus
-#define __PYX_EXTERN_C extern "C"
-#else
-#define __PYX_EXTERN_C extern
-#endif
-
-#if defined(WIN32) || defined(MS_WINDOWS)
-#define _USE_MATH_DEFINES
-#endif
-#include <math.h>
-#define __PYX_HAVE_API__csamtools
-#include "string.h"
-#include "stdlib.h"
-#include "math.h"
-#include "stdio.h"
-#include "ctype.h"
-#include "unistd.h"
-#include "fileobject.h"
-#include "razf.h"
-#include "stdint.h"
-#include "bam.h"
-#include "sam.h"
-#include "glf.h"
-#include "bam_maqcns.h"
-#include "faidx.h"
-#include "pysam_util.h"
-#include "pythread.h"
-
-/* inline attribute */
-#ifndef CYTHON_INLINE
-  #if defined(__GNUC__)
-    #define CYTHON_INLINE __inline__
-  #elif defined(_MSC_VER)
-    #define CYTHON_INLINE __inline
-  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
-    #define CYTHON_INLINE inline
-  #else
-    #define CYTHON_INLINE 
-  #endif
-#endif
-
-/* unused attribute */
-#ifndef CYTHON_UNUSED
-# if defined(__GNUC__)
-#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
-#     define CYTHON_UNUSED __attribute__ ((__unused__)) 
-#   else
-#     define CYTHON_UNUSED
-#   endif
-# elif defined(__ICC) || defined(__INTEL_COMPILER)
-#   define CYTHON_UNUSED __attribute__ ((__unused__)) 
-# else
-#   define CYTHON_UNUSED 
-# endif
-#endif
-
-typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
-
-
-/* Type Conversion Predeclarations */
-
-#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
-#define __Pyx_PyBytes_AsUString(s)   ((unsigned char*) PyBytes_AsString(s))
-
-#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
-static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
-static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
-
-static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
-static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
-static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
-
-#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
-
-
-#ifdef __GNUC__
-/* Test for GCC > 2.95 */
-#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)) 
-#define likely(x)   __builtin_expect(!!(x), 1)
-#define unlikely(x) __builtin_expect(!!(x), 0)
-#else /* __GNUC__ > 2 ... */
-#define likely(x)   (x)
-#define unlikely(x) (x)
-#endif /* __GNUC__ > 2 ... */
-#else /* __GNUC__ */
-#define likely(x)   (x)
-#define unlikely(x) (x)
-#endif /* __GNUC__ */
-    
-static PyObject *__pyx_m;
-static PyObject *__pyx_b;
-static PyObject *__pyx_empty_tuple;
-static PyObject *__pyx_empty_bytes;
-static int __pyx_lineno;
-static int __pyx_clineno = 0;
-static const char * __pyx_cfilenm= __FILE__;
-static const char *__pyx_filename;
-
-
-static const char *__pyx_f[] = {
-  "csamtools.pyx",
-  "csamtools.pxd",
-  "bool.pxd",
-};
-
-/* Type declarations */
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":388
- *      counter[0] += 1;
- * 
- * ctypedef struct MateData:             # <<<<<<<<<<<<<<
- *      char * name
- *      bam1_t * mate
- */
-
-typedef struct {
-  char *name;
-  bam1_t *mate;
-  uint32_t flag;
-} __pyx_t_9csamtools_MateData;
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1478
- * ##-------------------------------------------------------------------
- * ##-------------------------------------------------------------------
- * ctypedef struct __iterdata:             # <<<<<<<<<<<<<<
- *     samfile_t * samfile
- *     bam_iter_t iter
- */
-
-typedef struct {
-  samfile_t *samfile;
-  bam_iter_t iter;
-  faidx_t *fastafile;
-  int tid;
-  char *seq;
-  int seq_len;
-} __pyx_t_9csamtools___iterdata;
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1655
- *         bam_plp_set_mask( self.pileup_iter, self.mask )
- * 
- *     cdef setupIteratorData( self,             # <<<<<<<<<<<<<<
- *                             int tid,
- *                             int start,
- */
-
-struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData {
-  int __pyx_n;
-  int reopen;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3192
- *         bam_maqindel_ret_destroy(self._r)
- * 
- * cdef class IndelCallerBase:             # <<<<<<<<<<<<<<
- *     '''Base class for SNP callers.
- * 
- */
-
-struct __pyx_obj_9csamtools_IndelCallerBase {
-  PyObject_HEAD
-  bam_maqindel_opt_t *options;
-  struct __pyx_obj_9csamtools_IteratorColumn *iter;
-  int cap_mapQ;
-  int max_depth;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3330
- *         return self._call()
- * 
- * cdef class IteratorIndelCalls( IndelCallerBase ):             # <<<<<<<<<<<<<<
- *     """*(IteratorColumn iterator)*
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorIndelCalls {
-  struct __pyx_obj_9csamtools_IndelCallerBase __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":244
- * ## Public methods
- * ######################################################################
- * cdef class Fastafile:             # <<<<<<<<<<<<<<
- *     '''*(filename)*
- * 
- */
-
-struct __pyx_obj_9csamtools_Fastafile {
-  PyObject_HEAD
-  struct __pyx_vtabstruct_9csamtools_Fastafile *__pyx_vtab;
-  char *_filename;
-  faidx_t *fastafile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3103
- *         return call
- * 
- * cdef class IndelCall:             # <<<<<<<<<<<<<<
- *     '''the results of an indel call.'''
- *     cdef int _tid
- */
-
-struct __pyx_obj_9csamtools_IndelCall {
-  PyObject_HEAD
-  int _tid;
-  int _pos;
-  int _coverage;
-  int _rms_mapping_quality;
-  bam_maqindel_ret_t *_r;
-};
-
-/* "pysam/csamtools.pxd":388
- *     cdef bam1_t * _delegate
- * 
- * cdef class Samfile:             # <<<<<<<<<<<<<<
- *     cdef char * _filename
- *     # pointer to samfile
- */
-
-struct __pyx_obj_9csamtools_Samfile {
-  PyObject_HEAD
-  struct __pyx_vtabstruct_9csamtools_Samfile *__pyx_vtab;
-  char *_filename;
-  samfile_t *samfile;
-  bam_index_t *index;
-  int isbam;
-  int isremote;
-  bam1_t *b;
-  char *mode;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3287
- *         return call
- * 
- * cdef class IndelCaller( IndelCallerBase ):             # <<<<<<<<<<<<<<
- *     '''*(IteratorColumn iterator_column )*
- * 
- */
-
-struct __pyx_obj_9csamtools_IndelCaller {
-  struct __pyx_obj_9csamtools_IndelCallerBase __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":91
- *      return dest
- * 
- * cdef class PileupRead             # <<<<<<<<<<<<<<
- * cdef makePileupRead( bam_pileup1_t * src ):
- *     '''fill a  PileupRead object from a bam_pileup1_t * object.'''
- */
-
-struct __pyx_obj_9csamtools_PileupRead {
-  PyObject_HEAD
-  struct __pyx_obj_9csamtools_AlignedRead *_alignment;
-  int32_t _qpos;
-  int _indel;
-  int _level;
-  uint32_t _is_del;
-  uint32_t _is_head;
-  uint32_t _is_tail;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2816
- *     return retval, out_stderr, out_stdout
- * 
- * cdef class SNPCall:             # <<<<<<<<<<<<<<
- *     '''the results of a SNP call.'''
- *     cdef int _tid
- */
-
-struct __pyx_obj_9csamtools_SNPCall {
-  PyObject_HEAD
-  int _tid;
-  int _pos;
-  char _reference_base;
-  char _genotype;
-  int _consensus_quality;
-  int _snp_quality;
-  int _rms_mapping_quality;
-  int _coverage;
-};
-
-/* "pysam/csamtools.pxd":383
- * 
- * # need to declare all C fields and methods here
- * cdef class AlignedRead:             # <<<<<<<<<<<<<<
- * 
- *     # object that this AlignedRead represents
- */
-
-struct __pyx_obj_9csamtools_AlignedRead {
-  PyObject_HEAD
-  bam1_t *_delegate;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1542
- *     return ret
- * 
- * cdef class IteratorColumn:             # <<<<<<<<<<<<<<
- *     '''abstract base class for iterators over columns.
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorColumn {
-  PyObject_HEAD
-  struct __pyx_vtabstruct_9csamtools_IteratorColumn *__pyx_vtab;
-  struct __pyx_obj_9csamtools_IteratorRowRegion *iter;
-  int tid;
-  int pos;
-  int n_plp;
-  int mask;
-  const bam_pileup1_t * plp;
-  bam_plp_t pileup_iter;
-  __pyx_t_9csamtools___iterdata iterdata;
-  struct __pyx_obj_9csamtools_Samfile *samfile;
-  struct __pyx_obj_9csamtools_Fastafile *fastafile;
-  PyObject *stepper;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1712
- *             self.iterdata.seq = NULL
- * 
- * cdef class IteratorColumnRegion(IteratorColumn):             # <<<<<<<<<<<<<<
- *     '''iterates over a region only.
- *     '''
- */
-
-struct __pyx_obj_9csamtools_IteratorColumnRegion {
-  struct __pyx_obj_9csamtools_IteratorColumn __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1187
- * ##-------------------------------------------------------------------
- * ##-------------------------------------------------------------------
- * cdef class IteratorRow:             # <<<<<<<<<<<<<<
- *     '''abstract base class for iterators over mapped reads.
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorRow {
-  PyObject_HEAD
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1356
- *         if self.owns_samfile: samclose( self.fp )
- * 
- * cdef class IteratorRowAllRefs(IteratorRow):             # <<<<<<<<<<<<<<
- *     """iterates over all mapped reads by chaining iterators over each reference
- *     """
- */
-
-struct __pyx_obj_9csamtools_IteratorRowAllRefs {
-  struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
-  struct __pyx_obj_9csamtools_Samfile *samfile;
-  int tid;
-  struct __pyx_obj_9csamtools_IteratorRowRegion *rowiter;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1206
- *     pass
- * 
- * cdef class IteratorRowRegion(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile, int tid, int beg, int end, int reopen = True )*
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorRowRegion {
-  struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
-  struct __pyx_vtabstruct_9csamtools_IteratorRowRegion *__pyx_vtab;
-  bam_iter_t iter;
-  bam1_t *b;
-  int retval;
-  struct __pyx_obj_9csamtools_Samfile *samfile;
-  samfile_t *fp;
-  int owns_samfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1741
- *                                      self.n_plp )
- * 
- * cdef class IteratorColumnAllRefs(IteratorColumn):             # <<<<<<<<<<<<<<
- *     """iterates over all columns by chaining iterators over each reference
- *     """
- */
-
-struct __pyx_obj_9csamtools_IteratorColumnAllRefs {
-  struct __pyx_obj_9csamtools_IteratorColumn __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1402
- *                 raise StopIteration
- * 
- * cdef class IteratorRowSelection(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile)*
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorRowSelection {
-  struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
-  struct __pyx_vtabstruct_9csamtools_IteratorRowSelection *__pyx_vtab;
-  bam1_t *b;
-  int current_pos;
-  samfile_t *fp;
-  PyObject *positions;
-  int owns_samfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2873
- * 
- * 
- * cdef class SNPCallerBase:             # <<<<<<<<<<<<<<
- *     '''Base class for SNP callers.
- * 
- */
-
-struct __pyx_obj_9csamtools_SNPCallerBase {
-  PyObject_HEAD
-  struct __pyx_vtabstruct_9csamtools_SNPCallerBase *__pyx_vtab;
-  bam_maqcns_t *c;
-  struct __pyx_obj_9csamtools_IteratorColumn *iter;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3021
- *         return call
- * 
- * cdef class SNPCaller( SNPCallerBase ):             # <<<<<<<<<<<<<<
- *     '''*(IteratorColumn iterator_column )*
- * 
- */
-
-struct __pyx_obj_9csamtools_SNPCaller {
-  struct __pyx_obj_9csamtools_SNPCallerBase __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2946
- *         sys.stdout.flush()
- * 
- * cdef class IteratorSNPCalls( SNPCallerBase ):             # <<<<<<<<<<<<<<
- *     """*(IteratorColumn iterator)*
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorSNPCalls {
-  struct __pyx_obj_9csamtools_SNPCallerBase __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1292
- *         if self.owns_samfile: samclose( self.fp )
- * 
- * cdef class IteratorRowAll(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile, int reopen = True)*
- * 
- */
-
-struct __pyx_obj_9csamtools_IteratorRowAll {
-  struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
-  struct __pyx_vtabstruct_9csamtools_IteratorRowAll *__pyx_vtab;
-  bam1_t *b;
-  samfile_t *fp;
-  int owns_samfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3370
- * 
- * 
- * cdef class IndexedReads:             # <<<<<<<<<<<<<<
- *     """index a bamfile by read.
- * 
- */
-
-struct __pyx_obj_9csamtools_IndexedReads {
-  PyObject_HEAD
-  struct __pyx_obj_9csamtools_Samfile *samfile;
-  samfile_t *fp;
-  PyObject *index;
-  int owns_samfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":82
- *     return dest
- * 
- * cdef class PileupProxy             # <<<<<<<<<<<<<<
- * cdef makePileupProxy( bam_pileup1_t * plp, int tid, int pos, int n ):
- *      cdef PileupProxy dest = PileupProxy.__new__(PileupProxy)
- */
-
-struct __pyx_obj_9csamtools_PileupProxy {
-  PyObject_HEAD
-  bam_pileup1_t *plp;
-  int tid;
-  int pos;
-  int n_pu;
-};
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1542
- *     return ret
- * 
- * cdef class IteratorColumn:             # <<<<<<<<<<<<<<
- *     '''abstract base class for iterators over columns.
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorColumn {
-  int (*cnext)(struct __pyx_obj_9csamtools_IteratorColumn *);
-  char *(*getSequence)(struct __pyx_obj_9csamtools_IteratorColumn *);
-  PyObject *(*setMask)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *);
-  PyObject *(*setupIteratorData)(struct __pyx_obj_9csamtools_IteratorColumn *, int, int, int, struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData *__pyx_optional_args);
-  PyObject *(*reset)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *, PyObject *, PyObject *);
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumn *__pyx_vtabptr_9csamtools_IteratorColumn;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1712
- *             self.iterdata.seq = NULL
- * 
- * cdef class IteratorColumnRegion(IteratorColumn):             # <<<<<<<<<<<<<<
- *     '''iterates over a region only.
- *     '''
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion {
-  struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_base;
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion *__pyx_vtabptr_9csamtools_IteratorColumnRegion;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2873
- * 
- * 
- * cdef class SNPCallerBase:             # <<<<<<<<<<<<<<
- *     '''Base class for SNP callers.
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_SNPCallerBase {
-  PyObject *(*__dump)(struct __pyx_obj_9csamtools_SNPCallerBase *, glf1_t *, uint32_t, int);
-};
-static struct __pyx_vtabstruct_9csamtools_SNPCallerBase *__pyx_vtabptr_9csamtools_SNPCallerBase;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3021
- *         return call
- * 
- * cdef class SNPCaller( SNPCallerBase ):             # <<<<<<<<<<<<<<
- *     '''*(IteratorColumn iterator_column )*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_SNPCaller {
-  struct __pyx_vtabstruct_9csamtools_SNPCallerBase __pyx_base;
-};
-static struct __pyx_vtabstruct_9csamtools_SNPCaller *__pyx_vtabptr_9csamtools_SNPCaller;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1206
- *     pass
- * 
- * cdef class IteratorRowRegion(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile, int tid, int beg, int end, int reopen = True )*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorRowRegion {
-  bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowRegion *);
-  int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowRegion *);
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowRegion *__pyx_vtabptr_9csamtools_IteratorRowRegion;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1402
- *                 raise StopIteration
- * 
- * cdef class IteratorRowSelection(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile)*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorRowSelection {
-  bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowSelection *);
-  int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowSelection *);
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowSelection *__pyx_vtabptr_9csamtools_IteratorRowSelection;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1741
- *                                      self.n_plp )
- * 
- * cdef class IteratorColumnAllRefs(IteratorColumn):             # <<<<<<<<<<<<<<
- *     """iterates over all columns by chaining iterators over each reference
- *     """
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorColumnAllRefs {
-  struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_base;
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumnAllRefs *__pyx_vtabptr_9csamtools_IteratorColumnAllRefs;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":415
- * 
- * 
- * cdef class Samfile:             # <<<<<<<<<<<<<<
- *     '''*(filename, mode=None, template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_Samfile {
-  bam_header_t *(*_buildHeader)(struct __pyx_obj_9csamtools_Samfile *, PyObject *);
-  bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_Samfile *);
-  int (*cnext)(struct __pyx_obj_9csamtools_Samfile *);
-  int (*write)(struct __pyx_obj_9csamtools_Samfile *, struct __pyx_obj_9csamtools_AlignedRead *, int __pyx_skip_dispatch);
-  char *(*_getrname)(struct __pyx_obj_9csamtools_Samfile *, int);
-};
-static struct __pyx_vtabstruct_9csamtools_Samfile *__pyx_vtabptr_9csamtools_Samfile;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":244
- * ## Public methods
- * ######################################################################
- * cdef class Fastafile:             # <<<<<<<<<<<<<<
- *     '''*(filename)*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_Fastafile {
-  char *(*_fetch)(struct __pyx_obj_9csamtools_Fastafile *, char *, int, int, int *);
-};
-static struct __pyx_vtabstruct_9csamtools_Fastafile *__pyx_vtabptr_9csamtools_Fastafile;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1292
- *         if self.owns_samfile: samclose( self.fp )
- * 
- * cdef class IteratorRowAll(IteratorRow):             # <<<<<<<<<<<<<<
- *     """*(Samfile samfile, int reopen = True)*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorRowAll {
-  bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowAll *);
-  int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowAll *);
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowAll *__pyx_vtabptr_9csamtools_IteratorRowAll;
-
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2946
- *         sys.stdout.flush()
- * 
- * cdef class IteratorSNPCalls( SNPCallerBase ):             # <<<<<<<<<<<<<<
- *     """*(IteratorColumn iterator)*
- * 
- */
-
-struct __pyx_vtabstruct_9csamtools_IteratorSNPCalls {
-  struct __pyx_vtabstruct_9csamtools_SNPCallerBase __pyx_base;
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorSNPCalls *__pyx_vtabptr_9csamtools_IteratorSNPCalls;
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-              PyThreadState_GET()->c_profileobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);  \
-          Py_DECREF(exc_info);                                                             \
-      }                                                                                    \
-  }
-
-  #define __Pyx_TraceReturn(result)                                                  \
-  if (unlikely(__Pyx_use_tracing) && PyThreadState_GET()->use_tracing && PyThreadState_GET()->c_profilefunc) {  \
-      PyThreadState_GET()->c_profilefunc(                                            \
-          PyThreadState_GET()->c_profileobj, __pyx_frame, PyTrace_RETURN, (PyObject*)result);     \
-      CYTHON_FRAME_DEL;                                                               \
-  }
-
-  static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno); /*proto*/
-  static int __Pyx_TraceSetupAndCall(PyCodeObject** code, PyFrameObject** frame, const char *funcname, const char *srcfile, int firstlineno); /*proto*/
-
-#else
-
-  #define __Pyx_TraceDeclarations
-  #define __Pyx_TraceCall(funcname, srcfile, firstlineno) 
-  #define __Pyx_TraceException() 
-  #define __Pyx_TraceReturn(result) 
-
-#endif /* CYTHON_PROFILE */
-
-static CYTHON_INLINE PyObject* __Pyx_tp_new(PyObject* type_obj) {
-    return (PyObject*) (((PyTypeObject*)(type_obj))->tp_new(
-        (PyTypeObject*)(type_obj), __pyx_empty_tuple, NULL));
-}
-
-static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type); /*proto*/
-
-static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
-
-static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
-
-static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
-static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
-
-static CYTHON_INLINE int __Pyx_CheckKeywordStrings(PyObject *kwdict,
-    const char* function_name, int kw_allowed); /*proto*/
-
-static void __Pyx_RaiseDoubleKeywordsError(
-    const char* func_name, PyObject* kw_name); /*proto*/
-
-static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
-    Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found); /*proto*/
-
-static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[],     PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args,     const char* function_name); /*proto*/
-
-static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-
-static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
-    const char *name, int exact); /*proto*/
-
-static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-
-
-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
-    PyObject *r;
-    if (!j) return NULL;
-    r = PyObject_GetItem(o, j);
-    Py_DECREF(j);
-    return r;
-}
-
-
-#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
-                                                    __Pyx_GetItemInt_List_Fast(o, i) : \
-                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
-
-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
-    if (likely(o != Py_None)) {
-        if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
-            PyObject *r = PyList_GET_ITEM(o, i);
-            Py_INCREF(r);
-            return r;
-        }
-        else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
-            PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
-            Py_INCREF(r);
-            return r;
-        }
-    }
-    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
-}
-
-#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
-                                                    __Pyx_GetItemInt_Tuple_Fast(o, i) : \
-                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
-
-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
-    if (likely(o != Py_None)) {
-        if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
-            PyObject *r = PyTuple_GET_ITEM(o, i);
-            Py_INCREF(r);
-            return r;
-        }
-        else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
-            PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
-            Py_INCREF(r);
-            return r;
-        }
-    }
-    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
-}
-
-
-#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
-                                                    __Pyx_GetItemInt_Fast(o, i) : \
-                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
-
-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
-    PyObject *r;
-    if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
-        r = PyList_GET_ITEM(o, i);
-        Py_INCREF(r);
-    }
-    else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
-        r = PyTuple_GET_ITEM(o, i);
-        Py_INCREF(r);
-    }
-    else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
-        r = PySequence_GetItem(o, i);
-    }
-    else {
-        r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
-    }
-    return r;
-}
-
-static CYTHON_INLINE long __Pyx_NegateNonNeg(long b) { return unlikely(b < 0) ? b : !b; }
-static CYTHON_INLINE PyObject* __Pyx_PyBoolOrNull_FromLong(long b) {
-    return unlikely(b < 0) ? NULL : __Pyx_PyBool_FromLong(b);
-}
-
-static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void);
-
-static CYTHON_INLINE PyObject* __Pyx_PyObject_Append(PyObject* L, PyObject* x) {
-    if (likely(PyList_CheckExact(L))) {
-        if (PyList_Append(L, x) < 0) return NULL;
-        Py_INCREF(Py_None);
-        return Py_None; /* this is just to have an accurate signature */
-    }
-    else {
-        PyObject *r, *m;
-        m = __Pyx_GetAttrString(L, "append");
-        if (!m) return NULL;
-        r = PyObject_CallFunctionObjArgs(m, x, NULL);
-        Py_DECREF(m);
-        return r;
-    }
-}
-
-static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
-
-
-#if PY_MAJOR_VERSION >= 3
-static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
-    PyObject *value;
-    if (unlikely(d == Py_None)) {
-        __Pyx_RaiseNoneIndexingError();
-        return NULL;
-    }
-    value = PyDict_GetItemWithError(d, key);
-    if (unlikely(!value)) {
-        if (!PyErr_Occurred())
-            PyErr_SetObject(PyExc_KeyError, key);
-        return NULL;
-    }
-    Py_INCREF(value);
-    return value;
-}
-#else
-    #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
-#endif
-
-static PyObject* __Pyx_PyDict_GetItemDefault(PyObject* d, PyObject* key, PyObject* default_value) {
-    PyObject* value;
-#if PY_MAJOR_VERSION >= 3
-    value = PyDict_GetItemWithError(d, key);
-    if (unlikely(!value)) {
-        if (unlikely(PyErr_Occurred()))
-            return NULL;
-        value = default_value;
-    }
-    Py_INCREF(value);
-#else
-    if (PyString_CheckExact(key) || PyUnicode_CheckExact(key) || PyInt_CheckExact(key)) {
-        /* these presumably have safe hash functions */
-        value = PyDict_GetItem(d, key);
-        if (unlikely(!value)) {
-            value = default_value;
-        }
-        Py_INCREF(value);
-    } else {
-        PyObject *m;
-        m = __Pyx_GetAttrString(d, "get");
-        if (!m) return NULL;
-        value = PyObject_CallFunctionObjArgs(m, key,
-            (default_value == Py_None) ? NULL : default_value, NULL);
-        Py_DECREF(m);
-    }
-#endif
-    return value;
-}
-
-static CYTHON_INLINE long __Pyx_div_long(long, long); /* proto */
-
-static CYTHON_INLINE long __Pyx_mod_long(long, long); /* proto */
-
-#define __Pyx_DelItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
-                                                    __Pyx_DelItemInt_Fast(o, i) : \
-                                                    __Pyx_DelItem_Generic(o, to_py_func(i)))
-
-static CYTHON_INLINE int __Pyx_DelItem_Generic(PyObject *o, PyObject *j) {
-    int r;
-    if (!j) return -1;
-    r = PyObject_DelItem(o, j);
-    Py_DECREF(j);
-    return r;
-}
-
-static CYTHON_INLINE int __Pyx_DelItemInt_Fast(PyObject *o, Py_ssize_t i) {
-    if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_ass_item && likely(i >= 0))
-        return PySequence_DelItem(o, i);
-    else {
-        PyObject *j = PyInt_FromSsize_t(i);
-        return __Pyx_DelItem_Generic(o, j);
-    }
-}
-
-static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-
-static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
-
-static PyObject *__Pyx_CreateClass(PyObject *bases, PyObject *dict, PyObject *name, const char *modname); /*proto*/
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t);
-
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-
-static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject *);
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int32_t(int32_t);
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int64_t(int64_t);
-
-static CYTHON_INLINE uint64_t __Pyx_PyInt_from_py_uint64_t(PyObject *);
-
-static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject *);
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint8_t(uint8_t);
-
-static int __Pyx_Print(PyObject*, PyObject *, int); /*proto*/
-#if PY_MAJOR_VERSION >= 3
-static PyObject* __pyx_print = 0;
-static PyObject* __pyx_print_kwargs = 0;
-#endif
-
-static int __Pyx_PrintOne(PyObject* stream, PyObject *o); /*proto*/
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint64_t(uint64_t);
-
-static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
-
-static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
-
-static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
-
-static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
-
-static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
-
-static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
-
-static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
-
-static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
-
-static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
-
-static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
-
-static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
-
-static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
-
-static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
-
-static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
-
-static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
-
-static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
-
-static void __Pyx_WriteUnraisable(const char *name); /*proto*/
-
-static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict);  /*proto*/
-
-static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
-
-static int __Pyx_SetVtable(PyObject *dict, void *vtable); /*proto*/
-
-static void __Pyx_AddTraceback(const char *funcname); /*proto*/
-
-static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
-/* Module declarations from __builtin__ */
-
-/* Module declarations from cpython.version */
-
-/* Module declarations from cpython.ref */
-
-/* Module declarations from cpython.exc */
-
-/* Module declarations from cpython.module */
-
-/* Module declarations from cpython.mem */
-
-/* Module declarations from cpython.tuple */
-
-/* Module declarations from cpython.list */
-
-/* Module declarations from libc.stdio */
-
-/* Module declarations from cpython.object */
-
-/* Module declarations from cpython.sequence */
-
-/* Module declarations from cpython.mapping */
-
-/* Module declarations from cpython.iterator */
-
-/* Module declarations from cpython.type */
-
-/* Module declarations from cpython.number */
-
-/* Module declarations from cpython.int */
-
-/* Module declarations from __builtin__ */
-
-/* Module declarations from cpython.bool */
-
-static PyTypeObject *__pyx_ptype_7cpython_4bool_bool = 0;
-/* Module declarations from cpython.long */
-
-/* Module declarations from cpython.float */
-
-/* Module declarations from cpython.complex */
-
-/* Module declarations from cpython.string */
-
-/* Module declarations from cpython.unicode */
-
-/* Module declarations from cpython.dict */
-
-/* Module declarations from cpython.instance */
-
-/* Module declarations from cpython.function */
-
-/* Module declarations from cpython.method */
-
-/* Module declarations from cpython.weakref */
-
-/* Module declarations from cpython.getargs */
-
-/* Module declarations from cpython.pythread */
-
-/* Module declarations from cpython.cobject */
-
-/* Module declarations from cpython.oldbuffer */
-
-/* Module declarations from cpython.set */
-
-/* Module declarations from cpython.buffer */
-
-/* Module declarations from cpython.bytes */
-
-/* Module declarations from cpython.pycapsule */
-
-/* Module declarations from cpython */
-
-/* Module declarations from csamtools */
-
-static PyTypeObject *__pyx_ptype_9csamtools_file = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_AlignedRead = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_Samfile = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_PileupProxy = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_PileupRead = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_Fastafile = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorRow = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowRegion = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowAll = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowAllRefs = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowSelection = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumn = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumnRegion = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumnAllRefs = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_SNPCall = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_SNPCallerBase = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorSNPCalls = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_SNPCaller = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IndelCall = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IndelCallerBase = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IndelCaller = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IteratorIndelCalls = 0;
-static PyTypeObject *__pyx_ptype_9csamtools_IndexedReads = 0;
-static char *__pyx_v_9csamtools_bam_nt16_rev_table;
-static int __pyx_v_9csamtools_max_pos;
-static PyObject *__pyx_f_9csamtools_makeAlignedRead(bam1_t *); /*proto*/
-static PyObject *__pyx_f_9csamtools_makePileupProxy(bam_pileup1_t *, int, int, int); /*proto*/
-static PyObject *__pyx_f_9csamtools_makePileupRead(bam_pileup1_t *); /*proto*/
-static int __pyx_f_9csamtools_fetch_callback(bam1_t *, void *); /*proto*/
-static int __pyx_f_9csamtools_pileup_callback(uint32_t, uint32_t, int, bam_pileup1_t *, void *); /*proto*/
-static int __pyx_f_9csamtools_pileup_fetch_callback(bam1_t *, void *); /*proto*/
-static int __pyx_f_9csamtools_count_callback(bam1_t *, void *); /*proto*/
-static int __pyx_f_9csamtools_mate_callback(bam1_t *, void *); /*proto*/
-static int __pyx_f_9csamtools___advance_all(void *, bam1_t *); /*proto*/
-static int __pyx_f_9csamtools___advance_snpcalls(void *, bam1_t *); /*proto*/
-static CYTHON_INLINE int32_t __pyx_f_9csamtools_query_start(bam1_t *); /*proto*/
-static CYTHON_INLINE int32_t __pyx_f_9csamtools_query_end(bam1_t *); /*proto*/
-static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_seq_range(bam1_t *, uint32_t, uint32_t); /*proto*/
-static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_qual_range(bam1_t *, uint32_t, uint32_t); /*proto*/
-#define __Pyx_MODULE_NAME "csamtools"
-int __pyx_module_is_main_csamtools = 0;
-
-/* Implementation of csamtools */
-static PyObject *__pyx_builtin_open;
-static PyObject *__pyx_builtin_object;
-static PyObject *__pyx_builtin_map;
-static PyObject *__pyx_builtin_ValueError;
-static PyObject *__pyx_builtin_IOError;
-static PyObject *__pyx_builtin_OverflowError;
-static PyObject *__pyx_builtin_NotImplementedError;
-static PyObject *__pyx_builtin_KeyError;
-static PyObject *__pyx_builtin_StopIteration;
-static PyObject *__pyx_builtin_cmp;
-static PyObject *__pyx_builtin_chr;
-static PyObject *__pyx_builtin_TypeError;
-static PyObject *__pyx_builtin_range;
-static char __pyx_k_1[] = "\t";
-static char __pyx_k_2[] = "\n";
-static char __pyx_k_3[] = "calling len() on closed file";
-static char __pyx_k_4[] = "could not open file `%s`";
-static char __pyx_k_5[] = "I/O operation on closed file";
-static char __pyx_k_6[] = "no sequence/region supplied.";
-static char __pyx_k_7[] = "invalid region: start (%i) > end (%i)";
-static char __pyx_k_8[] = "";
-static char __pyx_k_9[] = "start out of range (%i)";
-static char __pyx_k_10[] = "end out of range (%i)";
-static char __pyx_k_11[] = "%s:%i-%i";
-static char __pyx_k_12[] = "invalid file opening mode `%s`";
-static char __pyx_k_13[] = "http:";
-static char __pyx_k_14[] = "ftp:";
-static char __pyx_k_15[] = "either supply options `template`, `header` or  both `referencenames` and `referencelengths` for writing";
-static char __pyx_k_16[] = "unequal names and lengths of reference sequences";
-static char __pyx_k_17[] = "-";
-static char __pyx_k_18[] = "file `%s` not found";
-static char __pyx_k_19[] = "could not open file (mode='%s') - is it SAM/BAM format?";
-static char __pyx_k_20[] = "file does not have valid header (mode='%s') - is it SAM/BAM format?";
-static char __pyx_k_21[] = "file header is empty (mode='%s') - is it SAM/BAM format?";
-static char __pyx_k_22[] = ".bai";
-static char __pyx_k_23[] = "error while opening index `%s` ";
-static char __pyx_k_24[] = "tid %i out of range 0<=tid<%i";
-static char __pyx_k_25[] = "[:-]";
-static char __pyx_k_26[] = "invalid reference `%s`";
-static char __pyx_k_27[] = "invalid coordinates: start (%i) > end (%i)";
-static char __pyx_k_28[] = "seek only available in bam files";
-static char __pyx_k_30[] = "fetch called on bamfile without index";
-static char __pyx_k_31[] = "callback functionality requires a region/reference";
-static char __pyx_k_32[] = "no index available for fetch";
-static char __pyx_k_33[] = "fetch called for samfile without header";
-static char __pyx_k_34[] = "fetch for a region is not available for sam files";
-static char __pyx_k_35[] = "callback not implemented yet";
-static char __pyx_k_36[] = "read %s: is unpaired";
-static char __pyx_k_37[] = "mate %s: is unmapped";
-static char __pyx_k_38[] = "mate not found";
-static char __pyx_k_40[] = "counting functionality requires a region/reference";
-static char __pyx_k_41[] = "count for a region is not available for sam files";
-static char __pyx_k_42[] = "no index available for pileup";
-static char __pyx_k_43[] = "pileup of samfiles not implemented yet";
-static char __pyx_k_44[] = "@";
-static char __pyx_k_45[] = "header line without '@': '%s'";
-static char __pyx_k_46[] = "header line with invalid type '%s': '%s'";
-static char __pyx_k_47[] = ":";
-static char __pyx_k_48[] = "unknown field code '%s' in record '%s'";
-static char __pyx_k_49[] = "multiple '%s' lines are not permitted";
-static char __pyx_k_50[] = "@%s";
-static char __pyx_k_51[] = "%s:%s";
-static char __pyx_k_52[] = "invalid type for record %s: %s, expected %s";
-static char __pyx_k_53[] = "incomplete sequence information in '%s'";
-static char __pyx_k_54[] = "no index available for iteration";
-static char __pyx_k_55[] = "can only use this iterator on bam files";
-static char __pyx_k_56[] = "reference sequence for '%s' (tid=%i) not found";
-static char __pyx_k_57[] = "unknown stepper option `%s` in IteratorColumn";
-static char __pyx_k_59[] = "error during iteration";
-static char __pyx_k_60[] = "Invalid clipping in CIGAR string";
-static char __pyx_k_61[] = "quality and sequence mismatch: %i != %i";
-static char __pyx_k_62[] = "%c";
-static char __pyx_k_63[] = "create_string_buffer";
-static char __pyx_k_64[] = "<cccf";
-static char __pyx_k_65[] = "<cccb";
-static char __pyx_k_66[] = "<ccch";
-static char __pyx_k_67[] = "integer %i out of range of BAM/SAM specification";
-static char __pyx_k_68[] = "<ccci";
-static char __pyx_k_69[] = "<cccB";
-static char __pyx_k_70[] = "<cccH";
-static char __pyx_k_71[] = "<cccI";
-static char __pyx_k_72[] = "<cccc";
-static char __pyx_k_73[] = "<ccc%is";
-static char __pyx_k_74[] = "tags field too large";
-static char __pyx_k_75[] = "tag '%s' not present";
-static char __pyx_k_76[] = "Contig index";
-static char __pyx_k_77[] = "Mapped position on contig";
-static char __pyx_k_78[] = "Contig index for mate pair";
-static char __pyx_k_79[] = "Position of mate pair";
-static char __pyx_k_80[] = "Insert size";
-static char __pyx_k_81[] = "Binary flag";
-static char __pyx_k_82[] = "Count of cigar entries";
-static char __pyx_k_83[] = "Cigar entries";
-static char __pyx_k_84[] = "Mapping quality";
-static char __pyx_k_85[] = "Bam index bin number";
-static char __pyx_k_86[] = "Length of query name";
-static char __pyx_k_87[] = "Query name";
-static char __pyx_k_88[] = "Length of query sequence";
-static char __pyx_k_89[] = "Query sequence";
-static char __pyx_k_90[] = "Quality scores";
-static char __pyx_k_91[] = "Length of auxilary data";
-static char __pyx_k_92[] = "Maximum data length";
-static char __pyx_k_93[] = "Current data length";
-static char __pyx_k_94[] = "%-30s %-10s= %s";
-static char __pyx_k_95[] = "(";
-static char __pyx_k_96[] = ")";
-static char __pyx_k_97[] = "This class cannot be instantiated from Python";
-static char __pyx_k__A[] = "A";
-static char __pyx_k__C[] = "C";
-static char __pyx_k__D[] = "D";
-static char __pyx_k__F[] = "F";
-static char __pyx_k__I[] = "I";
-static char __pyx_k__S[] = "S";
-static char __pyx_k__Z[] = "Z";
-static char __pyx_k__b[] = "b";
-static char __pyx_k__c[] = "c";
-static char __pyx_k__d[] = "d";
-static char __pyx_k__f[] = "f";
-static char __pyx_k__i[] = "i";
-static char __pyx_k__n[] = "n";
-static char __pyx_k__r[] = "r";
-static char __pyx_k__s[] = "s";
-static char __pyx_k__w[] = "w";
-static char __pyx_k__x[] = "x";
-static char __pyx_k_100[] = "No such file or directory: '%s'";
-static char __pyx_k_101[] = "-o";
-static char __pyx_k_102[] = "option -o is forbidden in samtools view";
-static char __pyx_k_103[] = "_rms_mapping_quality";
-static char __pyx_k_104[] = "--> read %i %s %i";
-static char __pyx_k_105[] = "pos=%i, cns=%i, q_r = %f, depth=%i, n=%i, rb=%i, cns-cq=%i %i %i %i";
-static char __pyx_k_106[] = "-------------------------------------\n";
-static char __pyx_k_107[] = "IteratorSNPCalls requires an pileup iterator with reference sequence";
-static char __pyx_k_108[] = "position %i out of bounds on reference sequence (len=%i)";
-static char __pyx_k_109[] = "no reads in region - no call";
-static char __pyx_k_110[] = "%s/%s";
-static char __pyx_k_111[] = "IndelCallerBase requires an pileup iterator with reference sequence";
-static char __pyx_k_112[] = "can only IndexReads on bam files";
-static char __pyx_k_113[] = "read %s not found";
-static char __pyx_k_114[] = "the query name (None if not present)";
-static char __pyx_k_115[] = "the :term:`cigar` alignment (None if not present).\n        ";
-static char __pyx_k_116[] = "read sequence bases, including :term:`soft clipped` bases (None if not present)";
-static char __pyx_k_117[] = "read sequence base qualities, including :term:`soft clipped` bases (None if not present)";
-static char __pyx_k_118[] = "aligned portion of the read and excludes any flanking bases that were :term:`soft clipped` (None if not present)\n\n        SAM/BAM files may included extra flanking bases sequences that were\n        not part of the alignment.  These bases may be the result of the\n        Smith-Waterman or other algorithms, which may not require alignments\n        that begin at the first residue or end at the last.  In addition,\n        extra sequencing adapters, multiplex identifiers, and low-quality bases that\n        were not considered for alignment may have been retained.";
-static char __pyx_k_119[] = "aligned query sequence quality values (None if not present)";
-static char __pyx_k_120[] = "start index of the aligned query portion of the sequence (0-based, inclusive)";
-static char __pyx_k_121[] = "end index of the aligned query portion of the sequence (0-based, exclusive)";
-static char __pyx_k_122[] = "Length of the aligned query sequence";
-static char __pyx_k_123[] = "the tags in the AUX field.\n\n        This property permits convenience access to \n        the tags. Changes it the returned list will\n        not update the tags automatically. Instead,\n        the following is required for adding a \n        new tag::\n\n            read.tags = read.tags + [(\"RG\",0)]\n\n        ";
-static char __pyx_k_124[] = "properties flag";
-static char __pyx_k_125[] = "\n        :term:`target` ID\n\n        DEPRECATED from pysam-0.4 - use tid in the future.\n        The rname field caused a lot of confusion as it returns\n        the :term:`target` ID instead of the reference sequence\n        name.\n\n        .. note::\n\n            This field contains the index of the reference sequence \n            in the sequence dictionary. To obtain the name\n            of the reference sequence, use :meth:`pysam.Samfile.getrname()`\n            \n        ";
-static char __pyx_k_126[] = "\n        :term:`target` ID\n\n        .. note::\n\n            This field contains the index of the reference sequence \n            in the sequence dictionary. To obtain the name\n            of the reference sequence, use :meth:`pysam.Samfile.getrname()`\n            \n        ";
-static char __pyx_k_127[] = "0-based leftmost coordinate";
-static char __pyx_k_128[] = "properties bin";
-static char __pyx_k_129[] = "length of the read (read only). Returns 0 if not given.";
-static char __pyx_k_130[] = "aligned end position of the read (read only).  Returns\n        None if not available.";
-static char __pyx_k_131[] = "aligned length of the read (read only).  Returns None if\n        not available.";
-static char __pyx_k_132[] = "mapping quality";
-static char __pyx_k_133[] = "the :term:`reference` id of the mate ";
-static char __pyx_k_134[] = "the position of the mate";
-static char __pyx_k_135[] = "the insert size";
-static char __pyx_k_136[] = "true if read is paired in sequencing";
-static char __pyx_k_137[] = "true if read is mapped in a proper pair";
-static char __pyx_k_138[] = "true if read itself is unmapped";
-static char __pyx_k_139[] = "true if the mate is unmapped";
-static char __pyx_k_140[] = "true if read is mapped to reverse strand";
-static char __pyx_k_141[] = "true is read is mapped to reverse strand";
-static char __pyx_k_142[] = "true if this is read1";
-static char __pyx_k_143[] = "true if this is read2";
-static char __pyx_k_144[] = "true if not primary alignment";
-static char __pyx_k_145[] = "true if QC failure";
-static char __pyx_k_146[] = "true if optical or PCR duplicate";
-static char __pyx_k_147[] = "a list of reference positions that this read aligns to.";
-static char __pyx_k_148[] = "number of :term:`filename` associated with this object.";
-static char __pyx_k_149[] = "number of :term:`reference` sequences in the file.";
-static char __pyx_k_150[] = "tuple with the names of :term:`reference` sequences.";
-static char __pyx_k_151[] = "tuple of the lengths of the :term:`reference` sequences. The lengths are in the same order as \n        :attr:`pysam.Samfile.references`\n        ";
-static char __pyx_k_152[] = "full contents of the :term:`sam file` header as a string.";
-static char __pyx_k_153[] = "header information within the :term:`sam file`. The records and fields are returned as \n        a two-level dictionary.\n        ";
-static char __pyx_k_154[] = "the chromosome ID as is defined in the header";
-static char __pyx_k_155[] = "number of reads mapping to this column.";
-static char __pyx_k_156[] = "list of reads (:class:`pysam.PileupRead`) aligned to this column";
-static char __pyx_k_157[] = "a :class:`pysam.AlignedRead` object of the aligned read";
-static char __pyx_k_158[] = "position of the read base at the pileup site, 0-based";
-static char __pyx_k_159[] = "indel length; 0 for no indel, positive for ins and negative for del";
-static char __pyx_k_160[] = "1 iff the base on the padded read is a deletion";
-static char __pyx_k_161[] = "current sequence length.";
-static char __pyx_k_162[] = "nucleotide position of SNP.";
-static char __pyx_k_163[] = "reference base at pos. ``N`` if no reference sequence supplied.";
-static char __pyx_k_164[] = "the genotype called.";
-static char __pyx_k_165[] = "the genotype quality (Phred-scaled).";
-static char __pyx_k_166[] = "the snp quality (Phred scaled) - probability of consensus being identical to reference sequence.";
-static char __pyx_k_167[] = "the root mean square (rms) of the mapping quality of all reads involved in the call.";
-static char __pyx_k_168[] = "coverage or read depth - the number of reads involved in the call.";
-static char __pyx_k_169[] = "sequence of first allele.";
-static char __pyx_k_170[] = "sequence of second allele.";
-static char __pyx_k_171[] = "reads supporting first allele.";
-static char __pyx_k_172[] = "=ACMGRSVTWYHKDBN";
-static char __pyx_k_173[] = "A pileup column. A pileup column contains  \n    all the reads that map to a certain target base.\n\n    tid      \n        chromosome ID as is defined in the header      \n    pos      \n        the target base coordinate (0-based)    \n    n \n        number of reads mapping to this column  \n    pileups  \n        list of reads (:class:`pysam.PileupRead`) aligned to this column    \n    ";
-static char __pyx_k_174[] = "\n    stderr is captured. \n    ";
-static char __pyx_k_175[] = "does nothing. stderr can't be redirected on windows";
-static char __pyx_k_176[] = "http://mail.python.org/pipermail/python-list/2000-June/038406.html";
-static char __pyx_k_177[] = "Fastafile._isOpen (line 265)";
-static char __pyx_k_178[] = "Fastafile._open (line 275)";
-static char __pyx_k_179[] = "Fastafile.fetch (line 306)";
-static char __pyx_k_180[] = "Samfile._isOpen (line 464)";
-static char __pyx_k_181[] = "Samfile._hasIndex (line 468)";
-static char __pyx_k_182[] = "Samfile._open (line 472)";
-static char __pyx_k_183[] = "Samfile.gettid (line 612)";
-static char __pyx_k_184[] = "Samfile.getrname (line 621)";
-static char __pyx_k_185[] = "Samfile._parseRegion (line 637)";
-static char __pyx_k_186[] = "Samfile.seek (line 691)";
-static char __pyx_k_187[] = "Samfile.tell (line 702)";
-static char __pyx_k_188[] = "Samfile.fetch (line 713)";
-static char __pyx_k_189[] = "Samfile.mate (line 782)";
-static char __pyx_k_190[] = "Samfile.count (line 825)";
-static char __pyx_k_191[] = "Samfile.pileup (line 869)";
-static char __pyx_k_192[] = "Samfile.close (line 953)";
-static char __pyx_k_193[] = "Samfile.write (line 969)";
-static char __pyx_k_194[] = "Samfile._buildLine (line 1078)";
-static char __pyx_k_195[] = "Samfile.__next__ (line 1173)";
-static char __pyx_k_196[] = "IteratorRowRegion.__next__ (line 1281)";
-static char __pyx_k_197[] = "IteratorRowAll.__next__ (line 1340)";
-static char __pyx_k_198[] = "IteratorRowAllRefs.__next__ (line 1375)";
-static char __pyx_k_199[] = "IteratorRowSelection.__next__ (line 1459)";
-static char __pyx_k_200[] = "IteratorRowSelection";
-static char __pyx_k_201[] = "IteratorColumn.addReference (line 1634)";
-static char __pyx_k_202[] = "IteratorColumn.hasReference (line 1642)";
-static char __pyx_k_203[] = "IteratorColumnRegion.__next__ (line 1724)";
-static char __pyx_k_204[] = "IteratorColumnRegion";
-static char __pyx_k_205[] = "IteratorColumnAllRefs.__next__ (line 1755)";
-static char __pyx_k_206[] = "IteratorColumnAllRefs";
-static char __pyx_k_207[] = "AlignedRead.__str__ (line 1903)";
-static char __pyx_k_208[] = "AlignedRead.compare (line 1928)";
-static char __pyx_k_209[] = "AlignedRead.overlap (line 2512)";
-static char __pyx_k_210[] = "AlignedRead.opt (line 2541)";
-static char __pyx_k_211[] = "AlignedRead.fancy_str (line 2563)";
-static char __pyx_k_212[] = "Outs.setdevice (line 2705)";
-static char __pyx_k_213[] = "Outs.setfile (line 2710)";
-static char __pyx_k_214[] = "Outs.restore (line 2723)";
-static char __pyx_k_215[] = "_samtools_dispatch (line 2734)";
-static char __pyx_k_216[] = "IteratorSNPCalls.__next__ (line 2969)";
-static char __pyx_k_217[] = "SNPCaller.call (line 3041)";
-static char __pyx_k_218[] = "IndelCaller.call (line 3306)";
-static char __pyx_k_219[] = "IteratorIndelCalls.__next__ (line 3353)";
-static char __pyx_k_220[] = "IndexedReads.build (line 3406)";
-static char __pyx_k__AS[] = "AS";
-static char __pyx_k__CL[] = "CL";
-static char __pyx_k__CN[] = "CN";
-static char __pyx_k__CO[] = "CO";
-static char __pyx_k__DS[] = "DS";
-static char __pyx_k__DT[] = "DT";
-static char __pyx_k__GO[] = "GO";
-static char __pyx_k__HD[] = "HD";
-static char __pyx_k__ID[] = "ID";
-static char __pyx_k__LB[] = "LB";
-static char __pyx_k__LN[] = "LN";
-static char __pyx_k__M5[] = "M5";
-static char __pyx_k__PG[] = "PG";
-static char __pyx_k__PI[] = "PI";
-static char __pyx_k__PL[] = "PL";
-static char __pyx_k__PN[] = "PN";
-static char __pyx_k__PU[] = "PU";
-static char __pyx_k__RG[] = "RG";
-static char __pyx_k__SM[] = "SM";
-static char __pyx_k__SN[] = "SN";
-static char __pyx_k__SO[] = "SO";
-static char __pyx_k__SP[] = "SP";
-static char __pyx_k__SQ[] = "SQ";
-static char __pyx_k__UR[] = "UR";
-static char __pyx_k__VN[] = "VN";
-static char __pyx_k___r[] = "_r";
-static char __pyx_k__fd[] = "fd";
-static char __pyx_k__fp[] = "fp";
-static char __pyx_k__id[] = "id";
-static char __pyx_k__os[] = "os";
-static char __pyx_k__rb[] = "rb";
-static char __pyx_k__re[] = "re";
-static char __pyx_k__wb[] = "wb";
-static char __pyx_k__wh[] = "wh";
-static char __pyx_k__all[] = "all";
-static char __pyx_k__bam[] = "bam";
-static char __pyx_k__beg[] = "beg";
-static char __pyx_k__bin[] = "bin";
-static char __pyx_k__chr[] = "chr";
-static char __pyx_k__cmp[] = "cmp";
-static char __pyx_k__dup[] = "dup";
-static char __pyx_k__end[] = "end";
-static char __pyx_k__map[] = "map";
-static char __pyx_k__opt[] = "opt";
-static char __pyx_k__plp[] = "plp";
-static char __pyx_k__pos[] = "pos";
-static char __pyx_k__q_r[] = "q_r";
-static char __pyx_k__raw[] = "raw";
-static char __pyx_k__seq[] = "seq";
-static char __pyx_k__sys[] = "sys";
-static char __pyx_k__tid[] = "tid";
-static char __pyx_k__wbu[] = "wbu";
-static char __pyx_k__Outs[] = "Outs";
-static char __pyx_k___pos[] = "_pos";
-static char __pyx_k___tid[] = "_tid";
-static char __pyx_k__args[] = "args";
-static char __pyx_k__call[] = "call";
-static char __pyx_k__cnt1[] = "cnt1";
-static char __pyx_k__cnt2[] = "cnt2";
-static char __pyx_k__core[] = "core";
-static char __pyx_k__data[] = "data";
-static char __pyx_k__dup2[] = "dup2";
-static char __pyx_k__flag[] = "flag";
-static char __pyx_k__hash[] = "hash";
-static char __pyx_k__iter[] = "iter";
-static char __pyx_k__join[] = "join";
-static char __pyx_k__mapq[] = "mapq";
-static char __pyx_k__mask[] = "mask";
-static char __pyx_k__mate[] = "mate";
-static char __pyx_k__mode[] = "mode";
-static char __pyx_k__mpos[] = "mpos";
-static char __pyx_k__mrnm[] = "mrnm";
-static char __pyx_k__mtid[] = "mtid";
-static char __pyx_k__n_pu[] = "n_pu";
-static char __pyx_k__name[] = "name";
-static char __pyx_k__open[] = "open";
-static char __pyx_k__path[] = "path";
-static char __pyx_k__port[] = "port";
-static char __pyx_k__qpos[] = "qpos";
-static char __pyx_k__qseq[] = "qseq";
-static char __pyx_k__qual[] = "qual";
-static char __pyx_k__rlen[] = "rlen";
-static char __pyx_k__seek[] = "seek";
-static char __pyx_k__self[] = "self";
-static char __pyx_k__tags[] = "tags";
-static char __pyx_k__tell[] = "tell";
-static char __pyx_k__text[] = "text";
-static char __pyx_k__view[] = "view";
-static char __pyx_k___call[] = "_call";
-static char __pyx_k___open[] = "_open";
-static char __pyx_k___qpos[] = "_qpos";
-static char __pyx_k__bqual[] = "bqual";
-static char __pyx_k__build[] = "build";
-static char __pyx_k__cigar[] = "cigar";
-static char __pyx_k__close[] = "close";
-static char __pyx_k__cnext[] = "cnext";
-static char __pyx_k__count[] = "count";
-static char __pyx_k__fetch[] = "fetch";
-static char __pyx_k__flush[] = "flush";
-static char __pyx_k__indel[] = "indel";
-static char __pyx_k__index[] = "index";
-static char __pyx_k__isbam[] = "isbam";
-static char __pyx_k__isize[] = "isize";
-static char __pyx_k__l_aux[] = "l_aux";
-static char __pyx_k__level[] = "level";
-static char __pyx_k__n_hap[] = "n_hap";
-static char __pyx_k__n_plp[] = "n_plp";
-static char __pyx_k__q_cns[] = "q_cns";
-static char __pyx_k__q_ref[] = "q_ref";
-static char __pyx_k__qname[] = "qname";
-static char __pyx_k__range[] = "range";
-static char __pyx_k__reset[] = "reset";
-static char __pyx_k__rname[] = "rname";
-static char __pyx_k__setfd[] = "setfd";
-static char __pyx_k__split[] = "split";
-static char __pyx_k__start[] = "start";
-static char __pyx_k__strip[] = "strip";
-static char __pyx_k__theta[] = "theta";
-static char __pyx_k__types[] = "types";
-static char __pyx_k__where[] = "where";
-static char __pyx_k__write[] = "write";
-static char __pyx_k___indel[] = "_indel";
-static char __pyx_k___level[] = "_level";
-static char __pyx_k__ctypes[] = "ctypes";
-static char __pyx_k__errmod[] = "errmod";
-static char __pyx_k__exists[] = "exists";
-static char __pyx_k__fields[] = "fields";
-static char __pyx_k__fileno[] = "fileno";
-static char __pyx_k__gettid[] = "gettid";
-static char __pyx_k__header[] = "header";
-static char __pyx_k__indel1[] = "indel1";
-static char __pyx_k__indel2[] = "indel2";
-static char __pyx_k__is_del[] = "is_del";
-static char __pyx_k__l_qseq[] = "l_qseq";
-static char __pyx_k__l_text[] = "l_text";
-static char __pyx_k__m_data[] = "m_data";
-static char __pyx_k__method[] = "method";
-static char __pyx_k__object[] = "object";
-static char __pyx_k__offset[] = "offset";
-static char __pyx_k__pileup[] = "pileup";
-static char __pyx_k__record[] = "record";
-static char __pyx_k__region[] = "region";
-static char __pyx_k__remove[] = "remove";
-static char __pyx_k__reopen[] = "reopen";
-static char __pyx_k__retval[] = "retval";
-static char __pyx_k__rg2lib[] = "rg2lib";
-static char __pyx_k__stderr[] = "stderr";
-static char __pyx_k__stdout[] = "stdout";
-static char __pyx_k__struct[] = "struct";
-static char __pyx_k__system[] = "system";
-static char __pyx_k__IOError[] = "IOError";
-static char __pyx_k__IntType[] = "IntType";
-static char __pyx_k__O_CREAT[] = "O_CREAT";
-static char __pyx_k__Samfile[] = "Samfile";
-static char __pyx_k__Windows[] = "Windows";
-static char __pyx_k____all__[] = "__all__";
-static char __pyx_k____del__[] = "__del__";
-static char __pyx_k____str__[] = "__str__";
-static char __pyx_k___isOpen[] = "_isOpen";
-static char __pyx_k___is_del[] = "_is_del";
-static char __pyx_k__compare[] = "compare";
-static char __pyx_k__devnull[] = "devnull";
-static char __pyx_k__is_head[] = "is_head";
-static char __pyx_k__is_tail[] = "is_tail";
-static char __pyx_k__isupper[] = "isupper";
-static char __pyx_k__l_qname[] = "l_qname";
-static char __pyx_k__mkstemp[] = "mkstemp";
-static char __pyx_k__n_cigar[] = "n_cigar";
-static char __pyx_k__options[] = "options";
-static char __pyx_k__overlap[] = "overlap";
-static char __pyx_k__pileups[] = "pileups";
-static char __pyx_k__q_indel[] = "q_indel";
-static char __pyx_k__r_indel[] = "r_indel";
-static char __pyx_k__release[] = "release";
-static char __pyx_k__restore[] = "restore";
-static char __pyx_k__rowiter[] = "rowiter";
-static char __pyx_k__samfile[] = "samfile";
-static char __pyx_k__seq_len[] = "seq_len";
-static char __pyx_k__setfile[] = "setfile";
-static char __pyx_k__stepper[] = "stepper";
-static char __pyx_k__streams[] = "streams";
-static char __pyx_k__DictType[] = "DictType";
-static char __pyx_k__KeyError[] = "KeyError";
-static char __pyx_k__O_WRONLY[] = "O_WRONLY";
-static char __pyx_k____dict__[] = "__dict__";
-static char __pyx_k____init__[] = "__init__";
-static char __pyx_k____main__[] = "__main__";
-static char __pyx_k____next__[] = "__next__";
-static char __pyx_k____test__[] = "__test__";
-static char __pyx_k___is_head[] = "_is_head";
-static char __pyx_k___is_tail[] = "_is_tail";
-static char __pyx_k___logfile[] = "_logfile";
-static char __pyx_k__calcsize[] = "calcsize";
-static char __pyx_k__callback[] = "callback";
-static char __pyx_k__cap_mapQ[] = "cap_mapQ";
-static char __pyx_k__cnt_anti[] = "cnt_anti";
-static char __pyx_k__coverage[] = "coverage";
-static char __pyx_k__data_len[] = "data_len";
-static char __pyx_k__exc_type[] = "exc_type";
-static char __pyx_k__filename[] = "filename";
-static char __pyx_k__genotype[] = "genotype";
-static char __pyx_k__getrname[] = "getrname";
-static char __pyx_k__het_rate[] = "het_rate";
-static char __pyx_k__isremote[] = "isremote";
-static char __pyx_k__iterdata[] = "iterdata";
-static char __pyx_k__nextiter[] = "nextiter";
-static char __pyx_k__platform[] = "platform";
-static char __pyx_k__samtools[] = "samtools";
-static char __pyx_k__stderr_f[] = "stderr_f";
-static char __pyx_k__stderr_h[] = "stderr_h";
-static char __pyx_k__tempfile[] = "tempfile";
-static char __pyx_k__template[] = "template";
-static char __pyx_k__Fastafile[] = "Fastafile";
-static char __pyx_k__FloatType[] = "FloatType";
-static char __pyx_k__SNPCaller[] = "SNPCaller";
-static char __pyx_k__TypeError[] = "TypeError";
-static char __pyx_k___coverage[] = "_coverage";
-static char __pyx_k___delegate[] = "_delegate";
-static char __pyx_k___filename[] = "_filename";
-static char __pyx_k___genotype[] = "_genotype";
-static char __pyx_k___hasIndex[] = "_hasIndex";
-static char __pyx_k__alignment[] = "alignment";
-static char __pyx_k__exc_value[] = "exc_value";
-static char __pyx_k__fancy_str[] = "fancy_str";
-static char __pyx_k__fastafile[] = "fastafile";
-static char __pyx_k__itertools[] = "itertools";
-static char __pyx_k__max_depth[] = "max_depth";
-static char __pyx_k__min_baseQ[] = "min_baseQ";
-static char __pyx_k__n_targets[] = "n_targets";
-static char __pyx_k__pack_into[] = "pack_into";
-static char __pyx_k__positions[] = "positions";
-static char __pyx_k__readlines[] = "readlines";
-static char __pyx_k__reference[] = "reference";
-static char __pyx_k__setdevice[] = "setdevice";
-static char __pyx_k__traceback[] = "traceback";
-static char __pyx_k__until_eof[] = "until_eof";
-static char __pyx_k__PileupRead[] = "PileupRead";
-static char __pyx_k__ValueError[] = "ValueError";
-static char __pyx_k___alignment[] = "_alignment";
-static char __pyx_k___buildLine[] = "_buildLine";
-static char __pyx_k__reads_diff[] = "reads_diff";
-static char __pyx_k__startswith[] = "startswith";
-static char __pyx_k__target_len[] = "target_len";
-static char __pyx_k__AlignedRead[] = "AlignedRead";
-static char __pyx_k__IndelCaller[] = "IndelCaller";
-static char __pyx_k__IteratorRow[] = "IteratorRow";
-static char __pyx_k__PileupProxy[] = "PileupProxy";
-static char __pyx_k__StderrStore[] = "StderrStore";
-static char __pyx_k__collections[] = "collections";
-static char __pyx_k__current_pos[] = "current_pos";
-static char __pyx_k__defaultdict[] = "defaultdict";
-static char __pyx_k__getSequence[] = "getSequence";
-static char __pyx_k__nreferences[] = "nreferences";
-static char __pyx_k__pileup_iter[] = "pileup_iter";
-static char __pyx_k__reads_first[] = "reads_first";
-static char __pyx_k__snp_quality[] = "snp_quality";
-static char __pyx_k__stderr_save[] = "stderr_save";
-static char __pyx_k__target_name[] = "target_name";
-static char __pyx_k__IndexedReads[] = "IndexedReads";
-static char __pyx_k__PileupColumn[] = "PileupColumn";
-static char __pyx_k___buildHeader[] = "_buildHeader";
-static char __pyx_k___parseRegion[] = "_parseRegion";
-static char __pyx_k___snp_quality[] = "_snp_quality";
-static char __pyx_k__addReference[] = "addReference";
-static char __pyx_k__catch_stderr[] = "catch_stderr";
-static char __pyx_k__catch_stdout[] = "catch_stdout";
-static char __pyx_k__first_allele[] = "first_allele";
-static char __pyx_k__hasReference[] = "hasReference";
-static char __pyx_k__n_haplotypes[] = "n_haplotypes";
-static char __pyx_k__owns_samfile[] = "owns_samfile";
-static char __pyx_k__reads_second[] = "reads_second";
-static char __pyx_k__OverflowError[] = "OverflowError";
-static char __pyx_k__StopIteration[] = "StopIteration";
-static char __pyx_k__VALID_HEADERS[] = "VALID_HEADERS";
-static char __pyx_k__second_allele[] = "second_allele";
-static char __pyx_k__IteratorColumn[] = "IteratorColumn";
-static char __pyx_k__IteratorRowAll[] = "IteratorRowAll";
-static char __pyx_k__readAndRelease[] = "readAndRelease";
-static char __pyx_k__reference_base[] = "reference_base";
-static char __pyx_k__referencenames[] = "referencenames";
-static char __pyx_k___reference_base[] = "_reference_base";
-static char __pyx_k__iterator_column[] = "iterator_column";
-static char __pyx_k__mapping_quality[] = "mapping_quality";
-static char __pyx_k__IteratorSNPCalls[] = "IteratorSNPCalls";
-static char __pyx_k____getattribute__[] = "__getattribute__";
-static char __pyx_k__referencelengths[] = "referencelengths";
-static char __pyx_k__IteratorRowRegion[] = "IteratorRowRegion";
-static char __pyx_k__consensus_quality[] = "consensus_quality";
-static char __pyx_k__setupIteratorData[] = "setupIteratorData";
-static char __pyx_k__IteratorIndelCalls[] = "IteratorIndelCalls";
-static char __pyx_k__IteratorRowAllRefs[] = "IteratorRowAllRefs";
-static char __pyx_k__StderrStoreWindows[] = "StderrStoreWindows";
-static char __pyx_k__VALID_HEADER_ORDER[] = "VALID_HEADER_ORDER";
-static char __pyx_k__VALID_HEADER_TYPES[] = "VALID_HEADER_TYPES";
-static char __pyx_k___consensus_quality[] = "_consensus_quality";
-static char __pyx_k___samtools_dispatch[] = "_samtools_dispatch";
-static char __pyx_k__NotImplementedError[] = "NotImplementedError";
-static char __pyx_k__VALID_HEADER_FIELDS[] = "VALID_HEADER_FIELDS";
-static PyObject *__pyx_kp_s_1;
-static PyObject *__pyx_kp_s_10;
-static PyObject *__pyx_kp_s_100;
-static PyObject *__pyx_kp_s_101;
-static PyObject *__pyx_kp_s_102;
-static PyObject *__pyx_n_s_103;
-static PyObject *__pyx_kp_s_104;
-static PyObject *__pyx_kp_s_105;
-static PyObject *__pyx_kp_s_107;
-static PyObject *__pyx_kp_s_108;
-static PyObject *__pyx_kp_s_109;
-static PyObject *__pyx_kp_s_11;
-static PyObject *__pyx_kp_s_110;
-static PyObject *__pyx_kp_s_111;
-static PyObject *__pyx_kp_s_112;
-static PyObject *__pyx_kp_s_113;
-static PyObject *__pyx_kp_s_12;
-static PyObject *__pyx_kp_s_15;
-static PyObject *__pyx_kp_s_16;
-static PyObject *__pyx_kp_s_173;
-static PyObject *__pyx_kp_s_174;
-static PyObject *__pyx_kp_s_175;
-static PyObject *__pyx_kp_s_176;
-static PyObject *__pyx_kp_u_177;
-static PyObject *__pyx_kp_u_178;
-static PyObject *__pyx_kp_u_179;
-static PyObject *__pyx_kp_s_18;
-static PyObject *__pyx_kp_u_180;
-static PyObject *__pyx_kp_u_181;
-static PyObject *__pyx_kp_u_182;
-static PyObject *__pyx_kp_u_183;
-static PyObject *__pyx_kp_u_184;
-static PyObject *__pyx_kp_u_185;
-static PyObject *__pyx_kp_u_186;
-static PyObject *__pyx_kp_u_187;
-static PyObject *__pyx_kp_u_188;
-static PyObject *__pyx_kp_u_189;
-static PyObject *__pyx_kp_s_19;
-static PyObject *__pyx_kp_u_190;
-static PyObject *__pyx_kp_u_191;
-static PyObject *__pyx_kp_u_192;
-static PyObject *__pyx_kp_u_193;
-static PyObject *__pyx_kp_u_194;
-static PyObject *__pyx_kp_u_195;
-static PyObject *__pyx_kp_u_196;
-static PyObject *__pyx_kp_u_197;
-static PyObject *__pyx_kp_u_198;
-static PyObject *__pyx_kp_u_199;
-static PyObject *__pyx_kp_s_2;
-static PyObject *__pyx_kp_s_20;
-static PyObject *__pyx_n_s_200;
-static PyObject *__pyx_kp_u_201;
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-static PyObject *__pyx_pf_9csamtools_9Fastafile_fetch(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
-static char __pyx_doc_9csamtools_9Fastafile_fetch[] = "Fastafile.fetch(self, reference=None, start=None, end=None, region=None)\n*(reference = None, start = None, end = None, region = None)*\n               \n        fetch :meth:`AlignedRead` objects in a :term:`region` using 0-based indexing. \n        \n        The region is specified by :term:`reference`, *start* and *end*. \n        \n        fetch returns an empty string if the region is out of range or addresses an unknown *reference*.\n\n        If *reference* is given and *start* is None, the sequence from the \n        first base is returned. Similarly, if *end* is None, the sequence \n        until the last base is returned.\n        \n        Alternatively, a samtools :term:`region` string can be supplied.\n        ";
-static PyObject *__pyx_pf_9csamtools_9Fastafile_fetch(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
-  PyObject *__pyx_v_reference = 0;
-  PyObject *__pyx_v_start = 0;
-  PyObject *__pyx_v_end = 0;
-  PyObject *__pyx_v_region = 0;
-  int __pyx_v_length;
-  char *__pyx_v_seq;
-  PyObject *__pyx_v_py_seq;
-  PyObject *__pyx_r = NULL;
-  PyObject *__pyx_t_1 = NULL;
-  PyObject *__pyx_t_2 = NULL;
-  int __pyx_t_3;
-  int __pyx_t_4;
-  char *__pyx_t_5;
-  static PyObject **__pyx_pyargnames[] = {&__pyx_n_s__reference,&__pyx_n_s__start,&__pyx_n_s__end,&__pyx_n_s__region,0};
-  __Pyx_TraceDeclarations
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-  if (unlikely(__pyx_kwds)) {
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-    PyObject* values[4] = {0,0,0,0};
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":307
- * 
- *     def fetch( self,
- *                reference = None,             # <<<<<<<<<<<<<<
- *                start = None,
- *                end = None,
- */
-    values[0] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":308
- *     def fetch( self,
- *                reference = None,
- *                start = None,             # <<<<<<<<<<<<<<
- *                end = None,
- *                region = None):
- */
-    values[1] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":309
- *                reference = None,
- *                start = None,
- *                end = None,             # <<<<<<<<<<<<<<
- *                region = None):
- * 
- */
-    values[2] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":310
- *                start = None,
- *                end = None,
- *                region = None):             # <<<<<<<<<<<<<<
- * 
- *         '''*(reference = None, start = None, end = None, region = None)*
- */
-    values[3] = ((PyObject *)Py_None);
-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
-      case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
-      case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
-      case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
-      case  0: break;
-      default: goto __pyx_L5_argtuple_error;
-    }
-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  0:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__reference);
-        if (value) { values[0] = value; kw_args--; }
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-      case  1:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__start);
-        if (value) { values[1] = value; kw_args--; }
-      }
-      case  2:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__end);
-        if (value) { values[2] = value; kw_args--; }
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-      case  3:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__region);
-        if (value) { values[3] = value; kw_args--; }
-      }
-    }
-    if (unlikely(kw_args > 0)) {
-      if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, PyTuple_GET_SIZE(__pyx_args), "fetch") < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 306; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    }
-    __pyx_v_reference = values[0];
-    __pyx_v_start = values[1];
-    __pyx_v_end = values[2];
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-  } else {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":307
- * 
- *     def fetch( self,
- *                reference = None,             # <<<<<<<<<<<<<<
- *                start = None,
- *                end = None,
- */
-    __pyx_v_reference = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":308
- *     def fetch( self,
- *                reference = None,
- *                start = None,             # <<<<<<<<<<<<<<
- *                end = None,
- *                region = None):
- */
-    __pyx_v_start = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":309
- *                reference = None,
- *                start = None,
- *                end = None,             # <<<<<<<<<<<<<<
- *                region = None):
- * 
- */
-    __pyx_v_end = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":310
- *                start = None,
- *                end = None,
- *                region = None):             # <<<<<<<<<<<<<<
- * 
- *         '''*(reference = None, start = None, end = None, region = None)*
- */
-    __pyx_v_region = ((PyObject *)Py_None);
-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  4: __pyx_v_region = PyTuple_GET_ITEM(__pyx_args, 3);
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":327
- *         '''
- * 
- *         if not self._isOpen():             # <<<<<<<<<<<<<<
- *             raise ValueError( "I/O operation on closed file" )
- * 
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-  __pyx_t_1 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___isOpen); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __pyx_t_2 = PyObject_Call(__pyx_t_1, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-  __pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_3 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  __pyx_t_4 = (!__pyx_t_3);
-  if (__pyx_t_4) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":328
- * 
- *         if not self._isOpen():
- *             raise ValueError( "I/O operation on closed file" )             # <<<<<<<<<<<<<<
- * 
- *         cdef int length
- */
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 328; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
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-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_5));
-    __pyx_t_1 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 328; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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-    goto __pyx_L6;
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-  __pyx_L6:;
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":333
- *         cdef char * seq
- * 
- *         if not region:             # <<<<<<<<<<<<<<
- *             if reference is None: raise ValueError( 'no sequence/region supplied.' )
- *             if start is None: start = 0
- */
-  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_v_region); if (unlikely(__pyx_t_4 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 333; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_t_3 = (!__pyx_t_4);
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":334
- * 
- *         if not region:
- *             if reference is None: raise ValueError( 'no sequence/region supplied.' )             # <<<<<<<<<<<<<<
- *             if start is None: start = 0
- *             if end is None: end = max_pos -1
- */
-    __pyx_t_3 = (__pyx_v_reference == Py_None);
-    if (__pyx_t_3) {
-      __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 334; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_1);
-      __Pyx_INCREF(((PyObject *)__pyx_kp_s_6));
-      PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)__pyx_kp_s_6));
-      __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_6));
-      __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 334; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-      __Pyx_Raise(__pyx_t_2, 0, 0);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 334; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L8;
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-    __pyx_L8:;
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":335
- *         if not region:
- *             if reference is None: raise ValueError( 'no sequence/region supplied.' )
- *             if start is None: start = 0             # <<<<<<<<<<<<<<
- *             if end is None: end = max_pos -1
- * 
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":336
- *             if reference is None: raise ValueError( 'no sequence/region supplied.' )
- *             if start is None: start = 0
- *             if end is None: end = max_pos -1             # <<<<<<<<<<<<<<
- * 
- *             if start > end: raise ValueError( 'invalid region: start (%i) > end (%i)' % (start, end) )
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-      __Pyx_GOTREF(__pyx_t_2);
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- *             if start > end: raise ValueError( 'invalid region: start (%i) > end (%i)' % (start, end) )             # <<<<<<<<<<<<<<
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-    __Pyx_GOTREF(__pyx_t_2);
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-      __Pyx_GOTREF(((PyObject *)__pyx_t_1));
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-      goto __pyx_L11;
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":339
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- *             if start == end: return ""             # <<<<<<<<<<<<<<
- *             # valid ranges are from 0 to 2^29-1
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- *                text = None,             # <<<<<<<<<<<<<<
- *                header = None,
- *                port = None,
- */
-    values[5] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":479
- *                referencelengths = None,
- *                text = None,
- *                header = None,             # <<<<<<<<<<<<<<
- *                port = None,
- *               ):
- */
-    values[6] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":480
- *                text = None,
- *                header = None,
- *                port = None,             # <<<<<<<<<<<<<<
- *               ):
- *         '''open a sam/bam file.
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-    values[7] = ((PyObject *)Py_None);
-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  8: values[7] = PyTuple_GET_ITEM(__pyx_args, 7);
-      case  7: values[6] = PyTuple_GET_ITEM(__pyx_args, 6);
-      case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
-      case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
-      case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
-      case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
-      case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
-      case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
-      case  0: break;
-      default: goto __pyx_L5_argtuple_error;
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-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  0:
-      values[0] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__filename);
-      if (likely(values[0])) kw_args--;
-      else goto __pyx_L5_argtuple_error;
-      case  1:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__mode);
-        if (value) { values[1] = value; kw_args--; }
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-      case  2:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__template);
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-      case  3:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__referencenames);
-        if (value) { values[3] = value; kw_args--; }
-      }
-      case  4:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__referencelengths);
-        if (value) { values[4] = value; kw_args--; }
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-      case  5:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__text);
-        if (value) { values[5] = value; kw_args--; }
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-      case  6:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__header);
-        if (value) { values[6] = value; kw_args--; }
-      }
-      case  7:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__port);
-        if (value) { values[7] = value; kw_args--; }
-      }
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-    if (unlikely(kw_args > 0)) {
-      if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, PyTuple_GET_SIZE(__pyx_args), "_open") < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 472; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    }
-    __pyx_v_filename = PyBytes_AsString(values[0]); if (unlikely((!__pyx_v_filename) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 473; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    __pyx_v_mode = values[1];
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-    __pyx_v_referencenames = values[3];
-    __pyx_v_referencelengths = values[4];
-    __pyx_v_text = values[5];
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":474
- *     def _open( self,
- *                char * filename,
- *                mode = None,             # <<<<<<<<<<<<<<
- *                Samfile template = None,
- *                referencenames = None,
- */
-    __pyx_v_mode = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":475
- *                char * filename,
- *                mode = None,
- *                Samfile template = None,             # <<<<<<<<<<<<<<
- *                referencenames = None,
- *                referencelengths = None,
- */
-    __pyx_v_template = ((struct __pyx_obj_9csamtools_Samfile *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":476
- *                mode = None,
- *                Samfile template = None,
- *                referencenames = None,             # <<<<<<<<<<<<<<
- *                referencelengths = None,
- *                text = None,
- */
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-
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- *                Samfile template = None,
- *                referencenames = None,
- *                referencelengths = None,             # <<<<<<<<<<<<<<
- *                text = None,
- *                header = None,
- */
-    __pyx_v_referencelengths = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":478
- *                referencenames = None,
- *                referencelengths = None,
- *                text = None,             # <<<<<<<<<<<<<<
- *                header = None,
- *                port = None,
- */
-    __pyx_v_text = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":479
- *                referencelengths = None,
- *                text = None,
- *                header = None,             # <<<<<<<<<<<<<<
- *                port = None,
- *               ):
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":480
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- *                port = None,             # <<<<<<<<<<<<<<
- *               ):
- *         '''open a sam/bam file.
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-    switch (PyTuple_GET_SIZE(__pyx_args)) {
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-      break;
-      default: goto __pyx_L5_argtuple_error;
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-  __Pyx_RaiseArgtupleInvalid("_open", 0, 1, 8, PyTuple_GET_SIZE(__pyx_args)); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 472; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
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-  return NULL;
-  __pyx_L4_argument_unpacking_done:;
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-  __pyx_v_n = Py_None; __Pyx_INCREF(Py_None);
-  __pyx_v_x = Py_None; __Pyx_INCREF(Py_None);
-  __pyx_v_name = Py_None; __Pyx_INCREF(Py_None);
-  __pyx_v_store = Py_None; __Pyx_INCREF(Py_None);
-  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_template), __pyx_ptype_9csamtools_Samfile, 1, "template", 0))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 475; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
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- *         # read mode autodetection
- *         if mode is None:             # <<<<<<<<<<<<<<
- *             try:
- *                 self._open(filename, 'r', template=template,
- */
-  __pyx_t_1 = (__pyx_v_mode == Py_None);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":490
- *         # read mode autodetection
- *         if mode is None:
- *             try:             # <<<<<<<<<<<<<<
- *                 self._open(filename, 'r', template=template,
- *                            referencenames=referencenames,
- */
-    {
-      PyObject *__pyx_save_exc_type, *__pyx_save_exc_value, *__pyx_save_exc_tb;
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-      __Pyx_XGOTREF(__pyx_save_exc_value);
-      __Pyx_XGOTREF(__pyx_save_exc_tb);
-      /*try:*/ {
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":491
- *         if mode is None:
- *             try:
- *                 self._open(filename, 'r', template=template,             # <<<<<<<<<<<<<<
- *                            referencenames=referencenames,
- *                            referencelengths=referencelengths,
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-        __pyx_t_2 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___open); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 491; __pyx_clineno = __LINE__; goto __pyx_L7_error;}
-        __Pyx_GOTREF(__pyx_t_2);
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-        __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-        if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__template), ((PyObject *)__pyx_v_template)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 491; __pyx_clineno = __LINE__; goto __pyx_L7_error;}
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":492
- *             try:
- *                 self._open(filename, 'r', template=template,
- *                            referencenames=referencenames,             # <<<<<<<<<<<<<<
- *                            referencelengths=referencelengths,
- *                            text=text, header=header, port=port)
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-
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- *                 self._open(filename, 'r', template=template,
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- *                            text=text, header=header, port=port)
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- *                            referencenames=referencenames,
- *                            referencelengths=referencelengths,
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- *                 return
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- */
-        if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__text), __pyx_v_text) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 491; __pyx_clineno = __LINE__; goto __pyx_L7_error;}
-        if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__header), __pyx_v_header) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 491; __pyx_clineno = __LINE__; goto __pyx_L7_error;}
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- *                            referencelengths=referencelengths,
- *                            text=text, header=header, port=port)
- *                 return             # <<<<<<<<<<<<<<
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- *                 pass
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-      __Pyx_XDECREF(__pyx_save_exc_value); __pyx_save_exc_value = 0;
-      __Pyx_XDECREF(__pyx_save_exc_tb); __pyx_save_exc_tb = 0;
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-      __Pyx_XGIVEREF(__pyx_save_exc_type);
-      __Pyx_XGIVEREF(__pyx_save_exc_value);
-      __Pyx_XGIVEREF(__pyx_save_exc_tb);
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-      goto __pyx_L0;
-      __pyx_L7_error:;
-      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
-      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
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- *                 return
- *             except ValueError, msg:             # <<<<<<<<<<<<<<
- *                 pass
- *             self._open(filename, 'rb', template=template,
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":509
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-  ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile = NULL;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":512
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- *         cdef bam_header_t * header_to_write
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-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->isbam = __pyx_t_6;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":519
- *         self.isbam = len(mode) > 1 and mode[1] == 'b'
- * 
- *         self.isremote = strncmp(filename,"http:",5) == 0 or \             # <<<<<<<<<<<<<<
- *             strncmp(filename,"ftp:",4) == 0
- * 
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-  __pyx_t_1 = (strncmp(__pyx_v_filename, __pyx_k_13, 5) == 0);
-  if (!__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":520
- * 
- *         self.isremote = strncmp(filename,"http:",5) == 0 or \
- *             strncmp(filename,"ftp:",4) == 0             # <<<<<<<<<<<<<<
- * 
- *         cdef char * ctext
- */
-    __pyx_t_7 = (strncmp(__pyx_v_filename, __pyx_k_14, 4) == 0);
-    __pyx_t_8 = __pyx_t_7;
-  } else {
-    __pyx_t_8 = __pyx_t_1;
-  }
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":519
- *         self.isbam = len(mode) > 1 and mode[1] == 'b'
- * 
- *         self.isremote = strncmp(filename,"http:",5) == 0 or \             # <<<<<<<<<<<<<<
- *             strncmp(filename,"ftp:",4) == 0
- * 
- */
-  ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->isremote = __pyx_t_8;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":523
- * 
- *         cdef char * ctext
- *         ctext = NULL             # <<<<<<<<<<<<<<
- * 
- *         if mode[0] == 'w':
- */
-  __pyx_v_ctext = NULL;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":525
- *         ctext = NULL
- * 
- *         if mode[0] == 'w':             # <<<<<<<<<<<<<<
- *             # open file for writing
- * 
- */
-  __pyx_t_2 = __Pyx_GetItemInt(__pyx_v_mode, 0, sizeof(long), PyInt_FromLong); if (!__pyx_t_2) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __pyx_t_3 = PyObject_RichCompare(__pyx_t_2, ((PyObject *)__pyx_n_s__w), Py_EQ); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  if (__pyx_t_8) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":529
- * 
- *             # header structure (used for writing)
- *             if template:             # <<<<<<<<<<<<<<
- *                 # copy header from another file
- *                 header_to_write = template.samfile.header
- */
-    __pyx_t_8 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_template)); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 529; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (__pyx_t_8) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":531
- *             if template:
- *                 # copy header from another file
- *                 header_to_write = template.samfile.header             # <<<<<<<<<<<<<<
- * 
- *             elif header:
- */
-      __pyx_v_header_to_write = __pyx_v_template->samfile->header;
-      goto __pyx_L20;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":533
- *                 header_to_write = template.samfile.header
- * 
- *             elif header:             # <<<<<<<<<<<<<<
- *                 header_to_write = self._buildHeader( header )
- * 
- */
-    __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_v_header); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 533; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (__pyx_t_8) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":534
- * 
- *             elif header:
- *                 header_to_write = self._buildHeader( header )             # <<<<<<<<<<<<<<
- * 
- *             else:
- */
-      __pyx_v_header_to_write = ((struct __pyx_vtabstruct_9csamtools_Samfile *)((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->__pyx_vtab)->_buildHeader(((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self), __pyx_v_header);
-      goto __pyx_L20;
-    }
-    /*else*/ {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":538
- *             else:
- *                 # build header from a target names and lengths
- *                 assert referencenames and referencelengths, "either supply options `template`, `header` or  both `referencenames` and `referencelengths` for writing"             # <<<<<<<<<<<<<<
- *                 assert len(referencenames) == len(referencelengths), "unequal names and lengths of reference sequences"
- * 
- */
-      #ifndef PYREX_WITHOUT_ASSERTIONS
-      __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_v_referencenames); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 538; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      if (__pyx_t_8) {
-        __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_referencelengths); if (unlikely(__pyx_t_1 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 538; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __pyx_t_7 = __pyx_t_1;
-      } else {
-        __pyx_t_7 = __pyx_t_8;
-      }
-      if (unlikely(!__pyx_t_7)) {
-        PyErr_SetObject(PyExc_AssertionError, ((PyObject *)__pyx_kp_s_15));
-        {__pyx_filename = __pyx_f[0]; __pyx_lineno = 538; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      }
-      #endif
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":539
- *                 # build header from a target names and lengths
- *                 assert referencenames and referencelengths, "either supply options `template`, `header` or  both `referencenames` and `referencelengths` for writing"
- *                 assert len(referencenames) == len(referencelengths), "unequal names and lengths of reference sequences"             # <<<<<<<<<<<<<<
- * 
- *                 # allocate and fill header
- */
-      #ifndef PYREX_WITHOUT_ASSERTIONS
-      __pyx_t_9 = PyObject_Length(__pyx_v_referencenames); if (unlikely(__pyx_t_9 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 539; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __pyx_t_10 = PyObject_Length(__pyx_v_referencelengths); if (unlikely(__pyx_t_10 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 539; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      if (unlikely(!(__pyx_t_9 == __pyx_t_10))) {
-        PyErr_SetObject(PyExc_AssertionError, ((PyObject *)__pyx_kp_s_16));
-        {__pyx_filename = __pyx_f[0]; __pyx_lineno = 539; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      }
-      #endif
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":542
- * 
- *                 # allocate and fill header
- *                 header_to_write = bam_header_init()             # <<<<<<<<<<<<<<
- *                 header_to_write.n_targets = len(referencenames)
- *                 n = 0
- */
-      __pyx_v_header_to_write = bam_header_init();
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":543
- *                 # allocate and fill header
- *                 header_to_write = bam_header_init()
- *                 header_to_write.n_targets = len(referencenames)             # <<<<<<<<<<<<<<
- *                 n = 0
- *                 for x in referencenames: n += len(x) + 1
- */
-      __pyx_t_10 = PyObject_Length(__pyx_v_referencenames); if (unlikely(__pyx_t_10 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 543; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __pyx_v_header_to_write->n_targets = __pyx_t_10;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":544
- *                 header_to_write = bam_header_init()
- *                 header_to_write.n_targets = len(referencenames)
- *                 n = 0             # <<<<<<<<<<<<<<
- *                 for x in referencenames: n += len(x) + 1
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))
- */
-      __Pyx_INCREF(__pyx_int_0);
-      __Pyx_DECREF(__pyx_v_n);
-      __pyx_v_n = __pyx_int_0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":545
- *                 header_to_write.n_targets = len(referencenames)
- *                 n = 0
- *                 for x in referencenames: n += len(x) + 1             # <<<<<<<<<<<<<<
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))
- */
-      if (PyList_CheckExact(__pyx_v_referencenames) || PyTuple_CheckExact(__pyx_v_referencenames)) {
-        __pyx_t_10 = 0; __pyx_t_3 = __pyx_v_referencenames; __Pyx_INCREF(__pyx_t_3);
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-        __Pyx_GOTREF(__pyx_t_3);
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-          __pyx_t_2 = PyIter_Next(__pyx_t_3);
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-            if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 545; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-        __pyx_t_2 = PyInt_FromSsize_t((__pyx_t_9 + 1)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 545; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __Pyx_GOTREF(__pyx_t_2);
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-        __Pyx_GOTREF(__pyx_t_5);
-        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-        __Pyx_DECREF(__pyx_v_n);
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- *                 n = 0
- *                 for x in referencenames: n += len(x) + 1
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))             # <<<<<<<<<<<<<<
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))
- *                 for x from 0 <= x < header_to_write.n_targets:
- */
-      __pyx_t_11 = __Pyx_PyInt_AsSize_t(__pyx_v_n); if (unlikely((__pyx_t_11 == (size_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 546; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __pyx_v_header_to_write->target_name = ((char **)calloc(__pyx_t_11, (sizeof(char *))));
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":547
- *                 for x in referencenames: n += len(x) + 1
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))             # <<<<<<<<<<<<<<
- *                 for x from 0 <= x < header_to_write.n_targets:
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- */
-      __pyx_t_11 = __Pyx_PyInt_AsSize_t(__pyx_v_n); if (unlikely((__pyx_t_11 == (size_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 547; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __pyx_v_header_to_write->target_len = ((uint32_t *)calloc(__pyx_t_11, (sizeof(uint32_t))));
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":548
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))
- *                 for x from 0 <= x < header_to_write.n_targets:             # <<<<<<<<<<<<<<
- *                     header_to_write.target_len[x] = referencelengths[x]
- *                     name = referencenames[x]
- */
-      __pyx_t_12 = __pyx_v_header_to_write->n_targets;
-      for (__pyx_t_13 = 0; __pyx_t_13 < __pyx_t_12; __pyx_t_13++) {
-        __pyx_t_3 = PyInt_FromLong(__pyx_t_13); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 548; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __Pyx_GOTREF(__pyx_t_3);
-        __Pyx_DECREF(__pyx_v_x);
-        __pyx_v_x = __pyx_t_3;
-        __pyx_t_3 = 0;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":549
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))
- *                 for x from 0 <= x < header_to_write.n_targets:
- *                     header_to_write.target_len[x] = referencelengths[x]             # <<<<<<<<<<<<<<
- *                     name = referencenames[x]
- *                     header_to_write.target_name[x] = <char*>calloc(len(name)+1, sizeof(char))
- */
-        __pyx_t_3 = PyObject_GetItem(__pyx_v_referencelengths, __pyx_v_x); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 549; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __Pyx_GOTREF(__pyx_t_3);
-        __pyx_t_14 = __Pyx_PyInt_from_py_uint32_t(__pyx_t_3); if (unlikely((__pyx_t_14 == (uint32_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 549; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-        __pyx_t_10 = __Pyx_PyIndex_AsSsize_t(__pyx_v_x); if (unlikely((__pyx_t_10 == (Py_ssize_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 549; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        (__pyx_v_header_to_write->target_len[__pyx_t_10]) = __pyx_t_14;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":550
- *                 for x from 0 <= x < header_to_write.n_targets:
- *                     header_to_write.target_len[x] = referencelengths[x]
- *                     name = referencenames[x]             # <<<<<<<<<<<<<<
- *                     header_to_write.target_name[x] = <char*>calloc(len(name)+1, sizeof(char))
- *                     strncpy( header_to_write.target_name[x], name, len(name) )
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-        __pyx_t_3 = PyObject_GetItem(__pyx_v_referencenames, __pyx_v_x); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 550; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __Pyx_GOTREF(__pyx_t_3);
-        __Pyx_DECREF(__pyx_v_name);
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-        __pyx_t_3 = 0;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":551
- *                     header_to_write.target_len[x] = referencelengths[x]
- *                     name = referencenames[x]
- *                     header_to_write.target_name[x] = <char*>calloc(len(name)+1, sizeof(char))             # <<<<<<<<<<<<<<
- *                     strncpy( header_to_write.target_name[x], name, len(name) )
- * 
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-        __pyx_t_9 = __Pyx_PyIndex_AsSsize_t(__pyx_v_x); if (unlikely((__pyx_t_9 == (Py_ssize_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 551; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        (__pyx_v_header_to_write->target_name[__pyx_t_9]) = ((char *)calloc((__pyx_t_10 + 1), (sizeof(char))));
-
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- *                     name = referencenames[x]
- *                     header_to_write.target_name[x] = <char*>calloc(len(name)+1, sizeof(char))
- *                     strncpy( header_to_write.target_name[x], name, len(name) )             # <<<<<<<<<<<<<<
- * 
- *                 if text != None:
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-        __pyx_t_10 = __Pyx_PyIndex_AsSsize_t(__pyx_v_x); if (unlikely((__pyx_t_10 == (Py_ssize_t)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 552; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __pyx_t_15 = PyBytes_AsString(__pyx_v_name); if (unlikely((!__pyx_t_15) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 552; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __pyx_t_9 = PyObject_Length(__pyx_v_name); if (unlikely(__pyx_t_9 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 552; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        strncpy((__pyx_v_header_to_write->target_name[__pyx_t_10]), __pyx_t_15, __pyx_t_9);
-        __pyx_t_13 = __Pyx_PyInt_AsLong(__pyx_v_x); if (unlikely((__pyx_t_13 == (long)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 548; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":548
- *                 header_to_write.target_name = <char**>calloc(n, sizeof(char*))
- *                 header_to_write.target_len = <uint32_t*>calloc(n, sizeof(uint32_t))
- *                 for x from 0 <= x < header_to_write.n_targets:             # <<<<<<<<<<<<<<
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-      __pyx_t_3 = PyInt_FromLong(__pyx_t_13); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 548; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      __Pyx_DECREF(__pyx_v_x);
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-
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- *                     strncpy( header_to_write.target_name[x], name, len(name) )
- * 
- *                 if text != None:             # <<<<<<<<<<<<<<
- *                     # copy without \0
- *                     ctext = text
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-      __pyx_t_3 = PyObject_RichCompare(__pyx_v_text, Py_None, Py_NE); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 554; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_7 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 554; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      if (__pyx_t_7) {
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":556
- *                 if text != None:
- *                     # copy without \0
- *                     ctext = text             # <<<<<<<<<<<<<<
- *                     header_to_write.l_text = strlen(ctext)
- *                     header_to_write.text = <char*>calloc( strlen(ctext), sizeof(char) )
- */
-        __pyx_t_15 = PyBytes_AsString(__pyx_v_text); if (unlikely((!__pyx_t_15) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 556; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-        __pyx_v_ctext = __pyx_t_15;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":557
- *                     # copy without \0
- *                     ctext = text
- *                     header_to_write.l_text = strlen(ctext)             # <<<<<<<<<<<<<<
- *                     header_to_write.text = <char*>calloc( strlen(ctext), sizeof(char) )
- *                     memcpy( header_to_write.text, ctext, strlen(ctext) )
- */
-        __pyx_v_header_to_write->l_text = strlen(__pyx_v_ctext);
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":558
- *                     ctext = text
- *                     header_to_write.l_text = strlen(ctext)
- *                     header_to_write.text = <char*>calloc( strlen(ctext), sizeof(char) )             # <<<<<<<<<<<<<<
- *                     memcpy( header_to_write.text, ctext, strlen(ctext) )
- * 
- */
-        __pyx_v_header_to_write->text = ((char *)calloc(strlen(__pyx_v_ctext), (sizeof(char))));
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":559
- *                     header_to_write.l_text = strlen(ctext)
- *                     header_to_write.text = <char*>calloc( strlen(ctext), sizeof(char) )
- *                     memcpy( header_to_write.text, ctext, strlen(ctext) )             # <<<<<<<<<<<<<<
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-        goto __pyx_L25;
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-
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- * 
- *                 header_to_write.hash = NULL             # <<<<<<<<<<<<<<
- *                 header_to_write.rg2lib = NULL
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- *                 header_to_write.hash = NULL
- *                 header_to_write.rg2lib = NULL             # <<<<<<<<<<<<<<
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- *             store = StderrStore()             # <<<<<<<<<<<<<<
- *             self.samfile = samopen( filename, mode, header_to_write )
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-    __pyx_t_3 = __Pyx_GetName(__pyx_m, __pyx_n_s__StderrStore); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 566; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-    __Pyx_GOTREF(__pyx_t_5);
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- *             store = StderrStore()
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- *             store.release()
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-
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- *             self.samfile = samopen( filename, mode, header_to_write )
- *             store.release()             # <<<<<<<<<<<<<<
- * 
- *             # bam_header_destroy takes care of cleaning up of all the members
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- * 
- *             # bam_header_destroy takes care of cleaning up of all the members
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- *                 bam_header_destroy( header_to_write )
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-    __pyx_t_8 = (!__pyx_t_7);
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-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":572
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":574
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- * 
- *         elif mode[0] == "r":             # <<<<<<<<<<<<<<
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- */
-  __pyx_t_3 = __Pyx_GetItemInt(__pyx_v_mode, 0, sizeof(long), PyInt_FromLong); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 574; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
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-  __Pyx_GOTREF(__pyx_t_5);
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-  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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-
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-
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- *             # open file for reading
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-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":578
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-      __pyx_t_3 = PyBytes_FromString(__pyx_v_filename); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 579; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-      __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_18), ((PyObject *)__pyx_t_3)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 579; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-      __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
-      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 579; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_t_2));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-      __pyx_t_2 = 0;
-      __pyx_t_2 = PyObject_Call(__pyx_builtin_IOError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 579; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __Pyx_Raise(__pyx_t_2, 0, 0);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 579; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L27;
-    }
-    __pyx_L27:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":582
- * 
- *             # try to detect errors
- *             self.samfile = samopen( filename, mode, NULL )             # <<<<<<<<<<<<<<
- *             if self.samfile == NULL:
- *                 raise ValueError( "could not open file (mode='%s') - is it SAM/BAM format?" % mode)
- */
-    __pyx_t_15 = PyBytes_AsString(__pyx_v_mode); if (unlikely((!__pyx_t_15) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 582; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile = samopen(__pyx_v_filename, __pyx_t_15, NULL);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":583
- *             # try to detect errors
- *             self.samfile = samopen( filename, mode, NULL )
- *             if self.samfile == NULL:             # <<<<<<<<<<<<<<
- *                 raise ValueError( "could not open file (mode='%s') - is it SAM/BAM format?" % mode)
- * 
- */
-    __pyx_t_8 = (((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile == NULL);
-    if (__pyx_t_8) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":584
- *             self.samfile = samopen( filename, mode, NULL )
- *             if self.samfile == NULL:
- *                 raise ValueError( "could not open file (mode='%s') - is it SAM/BAM format?" % mode)             # <<<<<<<<<<<<<<
- * 
- *             if self.samfile.header == NULL:
- */
-      __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_19), __pyx_v_mode); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 584; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 584; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_t_2));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-      __pyx_t_2 = 0;
-      __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 584; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __Pyx_Raise(__pyx_t_2, 0, 0);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 584; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L28;
-    }
-    __pyx_L28:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":586
- *                 raise ValueError( "could not open file (mode='%s') - is it SAM/BAM format?" % mode)
- * 
- *             if self.samfile.header == NULL:             # <<<<<<<<<<<<<<
- *                 raise ValueError( "file does not have valid header (mode='%s') - is it SAM/BAM format?" % mode )
- * 
- */
-    __pyx_t_8 = (((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile->header == NULL);
-    if (__pyx_t_8) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":587
- * 
- *             if self.samfile.header == NULL:
- *                 raise ValueError( "file does not have valid header (mode='%s') - is it SAM/BAM format?" % mode )             # <<<<<<<<<<<<<<
- * 
- *             #disabled for autodetection to work
- */
-      __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_20), __pyx_v_mode); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 587; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 587; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_t_2));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-      __pyx_t_2 = 0;
-      __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 587; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __Pyx_Raise(__pyx_t_2, 0, 0);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 587; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L29;
-    }
-    __pyx_L29:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":590
- * 
- *             #disabled for autodetection to work
- *             if self.samfile.header.n_targets == 0:             # <<<<<<<<<<<<<<
- *                 raise ValueError( "file header is empty (mode='%s') - is it SAM/BAM format?" % mode)
- * 
- */
-    __pyx_t_8 = (((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile->header->n_targets == 0);
-    if (__pyx_t_8) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":591
- *             #disabled for autodetection to work
- *             if self.samfile.header.n_targets == 0:
- *                 raise ValueError( "file header is empty (mode='%s') - is it SAM/BAM format?" % mode)             # <<<<<<<<<<<<<<
- * 
- *         if self.samfile == NULL:
- */
-      __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_21), __pyx_v_mode); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 591; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 591; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_t_2));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-      __pyx_t_2 = 0;
-      __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 591; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __Pyx_Raise(__pyx_t_2, 0, 0);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 591; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L30;
-    }
-    __pyx_L30:;
-    goto __pyx_L19;
-  }
-  __pyx_L19:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":593
- *                 raise ValueError( "file header is empty (mode='%s') - is it SAM/BAM format?" % mode)
- * 
- *         if self.samfile == NULL:             # <<<<<<<<<<<<<<
- *             raise IOError("could not open file `%s`" % filename )
- * 
- */
-  __pyx_t_8 = (((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile == NULL);
-  if (__pyx_t_8) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":594
- * 
- *         if self.samfile == NULL:
- *             raise IOError("could not open file `%s`" % filename )             # <<<<<<<<<<<<<<
- * 
- *         # check for index and open if present
- */
-    __pyx_t_2 = PyBytes_FromString(__pyx_v_filename); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 594; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-    __pyx_t_3 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_4), ((PyObject *)__pyx_t_2)); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 594; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-    __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 594; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_t_3));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_3));
-    __pyx_t_3 = 0;
-    __pyx_t_3 = PyObject_Call(__pyx_builtin_IOError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 594; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_3, 0, 0);
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 594; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L31;
-  }
-  __pyx_L31:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":597
- * 
- *         # check for index and open if present
- *         if mode[0] == "r" and self.isbam:             # <<<<<<<<<<<<<<
- * 
- *             if not self.isremote:
- */
-  __pyx_t_3 = __Pyx_GetItemInt(__pyx_v_mode, 0, sizeof(long), PyInt_FromLong); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 597; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __pyx_t_2 = PyObject_RichCompare(__pyx_t_3, ((PyObject *)__pyx_n_s__r), Py_EQ); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 597; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 597; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  if (__pyx_t_8) {
-    __pyx_t_1 = ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->isbam;
-  } else {
-    __pyx_t_1 = __pyx_t_8;
-  }
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":599
- *         if mode[0] == "r" and self.isbam:
- * 
- *             if not self.isremote:             # <<<<<<<<<<<<<<
- *                 if not os.path.exists(filename +".bai"):
- *                     self.index = NULL
- */
-    __pyx_t_1 = (!((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->isremote);
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":600
- * 
- *             if not self.isremote:
- *                 if not os.path.exists(filename +".bai"):             # <<<<<<<<<<<<<<
- *                     self.index = NULL
- *                 else:
- */
-      __pyx_t_2 = __Pyx_GetName(__pyx_m, __pyx_n_s__os); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __pyx_t_3 = PyObject_GetAttr(__pyx_t_2, __pyx_n_s__path); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      __pyx_t_2 = PyObject_GetAttr(__pyx_t_3, __pyx_n_s__exists); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __pyx_t_3 = PyBytes_FromString(__pyx_v_filename); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-      __pyx_t_5 = PyNumber_Add(((PyObject *)__pyx_t_3), ((PyObject *)__pyx_kp_s_22)); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_5);
-      __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
-      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_3);
-      PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_5);
-      __Pyx_GIVEREF(__pyx_t_5);
-      __pyx_t_5 = 0;
-      __pyx_t_5 = PyObject_Call(__pyx_t_2, __pyx_t_3, NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_5);
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-      __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_1 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 600; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-      __pyx_t_8 = (!__pyx_t_1);
-      if (__pyx_t_8) {
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":601
- *             if not self.isremote:
- *                 if not os.path.exists(filename +".bai"):
- *                     self.index = NULL             # <<<<<<<<<<<<<<
- *                 else:
- *                     # returns NULL if there is no index or index could not be opened
- */
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- * 
- *     def fetch( self,
- *                reference = None,             # <<<<<<<<<<<<<<
- *                start = None,
- *                end = None,
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- *                start = None,             # <<<<<<<<<<<<<<
- *                end = None,
- *                region = None,
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- *                end = None,             # <<<<<<<<<<<<<<
- *                region = None,
- *                callback = None,
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- *                region = None,             # <<<<<<<<<<<<<<
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- *                until_eof = False ):
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- *                callback = None,             # <<<<<<<<<<<<<<
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- *               AlignedRead read ):
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- */
-
-static PyObject *__pyx_pf_9csamtools_7Samfile_mate(PyObject *__pyx_v_self, PyObject *__pyx_v_read); /*proto*/
-static char __pyx_doc_9csamtools_7Samfile_mate[] = "Samfile.mate(self, AlignedRead read)\nreturn the mate of :class:`AlignedRead` *read*.\n\n        Throws a ValueError if read is unpaired or the mate\n        is unmapped.\n\n        .. note::\n            Calling this method will change the file position.\n            This might interfere with any iterators that have\n            not re-opened the file.\n\n        ";
-static PyObject *__pyx_pf_9csamtools_7Samfile_mate(PyObject *__pyx_v_self, PyObject *__pyx_v_read) {
-  uint32_t __pyx_v_flag;
-  __pyx_t_9csamtools_MateData __pyx_v_mate_data;
-  int __pyx_v_x;
-  struct __pyx_obj_9csamtools_AlignedRead *__pyx_v_dest = 0;
-  PyObject *__pyx_r = NULL;
-  int __pyx_t_1;
-  PyObject *__pyx_t_2 = NULL;
-  PyObject *__pyx_t_3 = NULL;
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("mate");
-  __Pyx_TraceCall("mate", __pyx_f[0], 782);
-  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_read), __pyx_ptype_9csamtools_AlignedRead, 1, "read", 0))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 783; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":795
- * 
- *         '''
- *         cdef uint32_t flag = read._delegate.core.flag             # <<<<<<<<<<<<<<
- * 
- *         if flag & BAM_FPAIRED == 0:
- */
-  __pyx_v_flag = ((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_read)->_delegate->core.flag;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":797
- *         cdef uint32_t flag = read._delegate.core.flag
- * 
- *         if flag & BAM_FPAIRED == 0:             # <<<<<<<<<<<<<<
- *             raise ValueError( "read %s: is unpaired" % (read.qname))
- *         if flag & BAM_FMUNMAP != 0:
- */
-  __pyx_t_1 = ((__pyx_v_flag & 1) == 0);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":798
- * 
- *         if flag & BAM_FPAIRED == 0:
- *             raise ValueError( "read %s: is unpaired" % (read.qname))             # <<<<<<<<<<<<<<
- *         if flag & BAM_FMUNMAP != 0:
- *             raise ValueError( "mate %s: is unmapped" % (read.qname))
- */
-    __pyx_t_2 = PyObject_GetAttr(__pyx_v_read, __pyx_n_s__qname); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 798; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __pyx_t_3 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_36), __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 798; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 798; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_t_3));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_3));
-    __pyx_t_3 = 0;
-    __pyx_t_3 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 798; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_3, 0, 0);
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 798; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L5;
-  }
-  __pyx_L5:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":799
- *         if flag & BAM_FPAIRED == 0:
- *             raise ValueError( "read %s: is unpaired" % (read.qname))
- *         if flag & BAM_FMUNMAP != 0:             # <<<<<<<<<<<<<<
- *             raise ValueError( "mate %s: is unmapped" % (read.qname))
- * 
- */
-  __pyx_t_1 = ((__pyx_v_flag & 8) != 0);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":800
- *             raise ValueError( "read %s: is unpaired" % (read.qname))
- *         if flag & BAM_FMUNMAP != 0:
- *             raise ValueError( "mate %s: is unmapped" % (read.qname))             # <<<<<<<<<<<<<<
- * 
- *         cdef MateData mate_data
- */
-    __pyx_t_3 = PyObject_GetAttr(__pyx_v_read, __pyx_n_s__qname); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 800; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_37), __pyx_t_3); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 800; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 800; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_t_2));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-    __pyx_t_2 = 0;
-    __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 800; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    __Pyx_Raise(__pyx_t_2, 0, 0);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 800; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L6;
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-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":804
- *         cdef MateData mate_data
- * 
- *         mate_data.name = <char *>bam1_qname(read._delegate)             # <<<<<<<<<<<<<<
- *         mate_data.mate = NULL
- *         # xor flags to get the other mate
- */
-  __pyx_v_mate_data.name = bam1_qname(((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_read)->_delegate);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":805
- * 
- *         mate_data.name = <char *>bam1_qname(read._delegate)
- *         mate_data.mate = NULL             # <<<<<<<<<<<<<<
- *         # xor flags to get the other mate
- *         cdef int x = BAM_FREAD1 + BAM_FREAD2
- */
-  __pyx_v_mate_data.mate = NULL;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":807
- *         mate_data.mate = NULL
- *         # xor flags to get the other mate
- *         cdef int x = BAM_FREAD1 + BAM_FREAD2             # <<<<<<<<<<<<<<
- *         mate_data.flag = ( flag ^ x) & x
- * 
- */
-  __pyx_v_x = 192;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":808
- *         # xor flags to get the other mate
- *         cdef int x = BAM_FREAD1 + BAM_FREAD2
- *         mate_data.flag = ( flag ^ x) & x             # <<<<<<<<<<<<<<
- * 
- *         bam_fetch(self.samfile.x.bam,
- */
-  __pyx_v_mate_data.flag = ((__pyx_v_flag ^ __pyx_v_x) & __pyx_v_x);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":816
- *                   read._delegate.core.mpos + 1,
- *                   <void*>&mate_data,
- *                   mate_callback )             # <<<<<<<<<<<<<<
- * 
- *         if mate_data.mate == NULL:
- */
-  bam_fetch(((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->samfile->x.bam, ((struct __pyx_obj_9csamtools_Samfile *)__pyx_v_self)->index, ((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_read)->_delegate->core.mtid, ((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_read)->_delegate->core.mpos, (((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_read)->_delegate->core.mpos + 1), ((void *)(&__pyx_v_mate_data)), __pyx_f_9csamtools_mate_callback);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":818
- *                   mate_callback )
- * 
- *         if mate_data.mate == NULL:             # <<<<<<<<<<<<<<
- *             raise ValueError( "mate not found" )
- * 
- */
-  __pyx_t_1 = (__pyx_v_mate_data.mate == NULL);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":819
- * 
- *         if mate_data.mate == NULL:
- *             raise ValueError( "mate not found" )             # <<<<<<<<<<<<<<
- * 
- *         cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)
- */
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 819; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-    __Pyx_INCREF(((PyObject *)__pyx_kp_s_38));
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-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_38));
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-    __Pyx_GOTREF(__pyx_t_3);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_3, 0, 0);
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-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 819; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L7;
-  }
-  __pyx_L7:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":821
- *             raise ValueError( "mate not found" )
- * 
- *         cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)             # <<<<<<<<<<<<<<
- *         dest._delegate = mate_data.mate
- *         return dest
- */
-  __pyx_t_3 = __Pyx_tp_new(((PyObject*)__pyx_ptype_9csamtools_AlignedRead)); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 821; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  if (!(likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_9csamtools_AlignedRead)))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 821; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_v_dest = ((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_t_3);
-  __pyx_t_3 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":822
- * 
- *         cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)
- *         dest._delegate = mate_data.mate             # <<<<<<<<<<<<<<
- *         return dest
- * 
- */
-  __pyx_v_dest->_delegate = __pyx_v_mate_data.mate;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":823
- *         cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)
- *         dest._delegate = mate_data.mate
- *         return dest             # <<<<<<<<<<<<<<
- * 
- *     def count( self,
- */
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-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
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-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_2);
-  __Pyx_XDECREF(__pyx_t_3);
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-  __pyx_L0:;
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-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":825
- *         return dest
- * 
- *     def count( self,             # <<<<<<<<<<<<<<
- *                reference = None,
- *                start = None,
- */
-
-static PyObject *__pyx_pf_9csamtools_7Samfile_count(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
-static char __pyx_doc_9csamtools_7Samfile_count[] = "Samfile.count(self, reference=None, start=None, end=None, region=None, until_eof=False)\n*(reference = None, start = None, end = None, region = None, callback = None, until_eof = False)*\n               \n        count  reads :term:`region` using 0-based indexing. The region is specified by\n        :term:`reference`, *start* and *end*. Alternatively, a samtools :term:`region` string can be supplied.\n\n        Note that a :term:`TAM` file does not allow random access. If *region* or *reference* are given,\n        an exception is raised.\n        ";
-static PyObject *__pyx_pf_9csamtools_7Samfile_count(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
-  PyObject *__pyx_v_reference = 0;
-  PyObject *__pyx_v_start = 0;
-  PyObject *__pyx_v_end = 0;
-  PyObject *__pyx_v_region = 0;
-  PyObject *__pyx_v_until_eof = 0;
-  int __pyx_v_rtid;
-  int __pyx_v_rstart;
-  int __pyx_v_rend;
-  int __pyx_v_counter;
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-  PyObject *__pyx_t_1 = NULL;
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-  __Pyx_TraceDeclarations
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":826
- * 
- *     def count( self,
- *                reference = None,             # <<<<<<<<<<<<<<
- *                start = None,
- *                end = None,
- */
-    values[0] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":827
- *     def count( self,
- *                reference = None,
- *                start = None,             # <<<<<<<<<<<<<<
- *                end = None,
- *                region = None,
- */
-    values[1] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":828
- *                reference = None,
- *                start = None,
- *                end = None,             # <<<<<<<<<<<<<<
- *                region = None,
- *                until_eof = False ):
- */
-    values[2] = ((PyObject *)Py_None);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":829
- *                start = None,
- *                end = None,
- *                region = None,             # <<<<<<<<<<<<<<
- *                until_eof = False ):
- *         '''*(reference = None, start = None, end = None, region = None, callback = None, until_eof = False)*
- */
-    values[3] = ((PyObject *)Py_None);
-    values[4] = __pyx_k_39;
-    switch (PyTuple_GET_SIZE(__pyx_args)) {
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- *             raise ValueError ("count for a region is not available for sam files" )
- * 
- *     def pileup( self,             # <<<<<<<<<<<<<<
- *                 reference = None,
- *                 start = None,
- */
-
-static PyObject *__pyx_pf_9csamtools_7Samfile_pileup(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
-static char __pyx_doc_9csamtools_7Samfile_pileup[] = "Samfile.pileup(self, reference=None, start=None, end=None, region=None, callback=None, **kwargs)\n\n        perform a :term:`pileup` within a :term:`region`. The region is specified by\n        :term:`reference`, *start* and *end* (using 0-based indexing). \n        Alternatively, a samtools *region* string can be supplied.\n\n        Without *reference* or *region* all reads will be used for the pileup. The reads will be returned\n        ordered by :term:`reference` sequence, which will not necessarily be the order within the file.\n\n        The method returns an iterator of type :class:`pysam.IteratorColumn` unless\n        a *callback is provided. If a *callback* is given, the callback will be executed \n        for each column within the :term:`region`. \n\n        Note that :term:`SAM` formatted files do not allow random access. \n        In these files, if a *region* or *reference* are given an exception is raised.\n        \n        Optional *kwargs* to the iterator:\n\n        stepper\n           The stepper controlls how the iterator advances. \n           Possible options for the stepper are \n       \n           ``all``\n              use all reads for pileup.\n           ``samtools``\n              same filter and read processing as in :term:`csamtools` pileup\n\n        fastafile\n           A :class:`FastaFile` object\n\n         mask\n           Skip all reads with bits set in mask.\n\n\n        .. note::\n\n            *all* reads which overlap the region are returned. The first base returned will be the \n            first base of the first read *not* necessarily the first base of the region used in the query.\n\n            The maximum number of reads considered for pileup is *8000*. This limit is set by\n            :term:`csamtools`.\n\n        ";
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- * 
- *     def pileup( self,
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- *                 start = None,
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- *     def pileup( self,
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- *                 start = None,             # <<<<<<<<<<<<<<
- *                 end = None,
- *                 region = None,
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- *                 end = None,             # <<<<<<<<<<<<<<
- *                 region = None,
- *                 callback = None,
- */
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- *                 region = None,             # <<<<<<<<<<<<<<
- *                 callback = None,
- *                 **kwargs ):
- */
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- *                 callback = None,             # <<<<<<<<<<<<<<
- *                 **kwargs ):
- *         '''
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":870
- * 
- *     def pileup( self,
- *                 reference = None,             # <<<<<<<<<<<<<<
- *                 start = None,
- *                 end = None,
- */
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":871
- *     def pileup( self,
- *                 reference = None,
- *                 start = None,             # <<<<<<<<<<<<<<
- *                 end = None,
- *                 region = None,
- */
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- *                 reference = None,
- *                 start = None,
- *                 end = None,             # <<<<<<<<<<<<<<
- *                 region = None,
- *                 callback = None,
- */
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- *                 end = None,
- *                 region = None,             # <<<<<<<<<<<<<<
- *                 callback = None,
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- * 
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- *         if dest.text != NULL: free( dest.text )
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- *         dest.text = <char*>calloc( len(text), sizeof(char))
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- *             dest.target_len = <uint32_t*>calloc( dest.n_targets, sizeof(uint32_t) )
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-      else goto __pyx_L5_argtuple_error;
-      case  1:
-      values[1] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__tid);
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-      else {
-        __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 4, 5, 1); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
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-      case  2:
-      values[2] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__beg);
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-      else {
-        __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 4, 5, 2); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      }
-      case  3:
-      values[3] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__end);
-      if (likely(values[3])) kw_args--;
-      else {
-        __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 4, 5, 3); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      }
-      case  4:
-      if (kw_args > 0) {
-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__reopen);
-        if (value) { values[4] = value; kw_args--; }
-      }
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-    if (unlikely(kw_args > 0)) {
-      if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, PyTuple_GET_SIZE(__pyx_args), "__cinit__") < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    }
-    __pyx_v_samfile = ((struct __pyx_obj_9csamtools_Samfile *)values[0]);
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-    __pyx_v_beg = __Pyx_PyInt_AsInt(values[2]); if (unlikely((__pyx_v_beg == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    __pyx_v_end = __Pyx_PyInt_AsInt(values[3]); if (unlikely((__pyx_v_end == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    if (values[4]) {
-      __pyx_v_reopen = __Pyx_PyInt_AsInt(values[4]); if (unlikely((__pyx_v_reopen == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-    } else {
-      __pyx_v_reopen = ((int)1);
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-    __pyx_v_reopen = ((int)1);
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-      __pyx_v_reopen = __Pyx_PyInt_AsInt(PyTuple_GET_ITEM(__pyx_args, 4)); if (unlikely((__pyx_v_reopen == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      case  4:
-      __pyx_v_end = __Pyx_PyInt_AsInt(PyTuple_GET_ITEM(__pyx_args, 3)); if (unlikely((__pyx_v_end == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      __pyx_v_beg = __Pyx_PyInt_AsInt(PyTuple_GET_ITEM(__pyx_args, 2)); if (unlikely((__pyx_v_beg == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      __pyx_v_tid = __Pyx_PyInt_AsInt(PyTuple_GET_ITEM(__pyx_args, 1)); if (unlikely((__pyx_v_tid == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-      __pyx_v_samfile = ((struct __pyx_obj_9csamtools_Samfile *)PyTuple_GET_ITEM(__pyx_args, 0));
-      break;
-      default: goto __pyx_L5_argtuple_error;
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-  goto __pyx_L4_argument_unpacking_done;
-  __pyx_L5_argtuple_error:;
-  __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 4, 5, PyTuple_GET_SIZE(__pyx_args)); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
-  __pyx_L3_error:;
-  __Pyx_AddTraceback("csamtools.IteratorRowRegion.__cinit__");
-  __Pyx_RefNannyFinishContext();
-  return -1;
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-  __pyx_v_store = Py_None; __Pyx_INCREF(Py_None);
-  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_samfile), __pyx_ptype_9csamtools_Samfile, 1, "samfile", 0))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1234; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1236
- *     def __cinit__(self, Samfile samfile, int tid, int beg, int end, int reopen = True ):
- * 
- *         if not samfile._isOpen():             # <<<<<<<<<<<<<<
- *             raise ValueError( "I/O operation on closed file" )
- * 
- */
-  __pyx_t_1 = PyObject_GetAttr(((PyObject *)__pyx_v_samfile), __pyx_n_s___isOpen); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1236; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __pyx_t_2 = PyObject_Call(__pyx_t_1, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1236; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-  __pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_3 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1236; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  __pyx_t_4 = (!__pyx_t_3);
-  if (__pyx_t_4) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1237
- * 
- *         if not samfile._isOpen():
- *             raise ValueError( "I/O operation on closed file" )             # <<<<<<<<<<<<<<
- * 
- *         if not samfile._hasIndex():
- */
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_INCREF(((PyObject *)__pyx_kp_s_5));
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_kp_s_5));
-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_5));
-    __pyx_t_1 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_1, 0, 0);
-    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L6;
-  }
-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1239
- *             raise ValueError( "I/O operation on closed file" )
- * 
- *         if not samfile._hasIndex():             # <<<<<<<<<<<<<<
- *             raise ValueError( "no index available for iteration" )
- * 
- */
-  __pyx_t_1 = PyObject_GetAttr(((PyObject *)__pyx_v_samfile), __pyx_n_s___hasIndex); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1239; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __pyx_t_2 = PyObject_Call(__pyx_t_1, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1239; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_4 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1239; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  __pyx_t_3 = (!__pyx_t_4);
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1240
- * 
- *         if not samfile._hasIndex():
- *             raise ValueError( "no index available for iteration" )             # <<<<<<<<<<<<<<
- * 
- *         # makes sure that samfile stays alive as long as the
- */
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_INCREF(((PyObject *)__pyx_kp_s_54));
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_kp_s_54));
-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_54));
-    __pyx_t_1 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_1, 0, 0);
-    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L7;
-  }
-  __pyx_L7:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1244
- *         # makes sure that samfile stays alive as long as the
- *         # iterator is alive
- *         self.samfile = samfile             # <<<<<<<<<<<<<<
- * 
- *         if samfile.isbam: mode = "rb"
- */
-  __Pyx_INCREF(((PyObject *)__pyx_v_samfile));
-  __Pyx_GIVEREF(((PyObject *)__pyx_v_samfile));
-  __Pyx_GOTREF(((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->samfile);
-  __Pyx_DECREF(((PyObject *)((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->samfile));
-  ((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->samfile = __pyx_v_samfile;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1246
- *         self.samfile = samfile
- * 
- *         if samfile.isbam: mode = "rb"             # <<<<<<<<<<<<<<
- *         else: mode = "r"
- * 
- */
-  if (__pyx_v_samfile->isbam) {
-    __Pyx_INCREF(((PyObject *)__pyx_n_s__rb));
-    __Pyx_DECREF(__pyx_v_mode);
-    __pyx_v_mode = ((PyObject *)__pyx_n_s__rb);
-    goto __pyx_L8;
-  }
-  /*else*/ {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1247
- * 
- *         if samfile.isbam: mode = "rb"
- *         else: mode = "r"             # <<<<<<<<<<<<<<
- * 
- *         # reopen the file - note that this makes the iterator
- */
-    __Pyx_INCREF(((PyObject *)__pyx_n_s__r));
-    __Pyx_DECREF(__pyx_v_mode);
-    __pyx_v_mode = ((PyObject *)__pyx_n_s__r);
-  }
-  __pyx_L8:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1251
- *         # reopen the file - note that this makes the iterator
- *         # slow and causes pileup to slow down significantly.
- *         if reopen:             # <<<<<<<<<<<<<<
- *             store = StderrStore()
- *             self.fp = samopen( samfile._filename, mode, NULL )
- */
-  if (__pyx_v_reopen) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1252
- *         # slow and causes pileup to slow down significantly.
- *         if reopen:
- *             store = StderrStore()             # <<<<<<<<<<<<<<
- *             self.fp = samopen( samfile._filename, mode, NULL )
- *             store.release()
- */
-    __pyx_t_1 = __Pyx_GetName(__pyx_m, __pyx_n_s__StderrStore); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1252; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __pyx_t_2 = PyObject_Call(__pyx_t_1, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1252; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-    __Pyx_DECREF(__pyx_v_store);
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- *         if reopen:
- *             store = StderrStore()
- *             self.fp = samopen( samfile._filename, mode, NULL )             # <<<<<<<<<<<<<<
- *             store.release()
- *             assert self.fp != NULL
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-    __pyx_t_5 = PyBytes_AsString(__pyx_v_mode); if (unlikely((!__pyx_t_5) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1253; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    ((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->fp = samopen(__pyx_v_samfile->_filename, __pyx_t_5, NULL);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1254
- *             store = StderrStore()
- *             self.fp = samopen( samfile._filename, mode, NULL )
- *             store.release()             # <<<<<<<<<<<<<<
- *             assert self.fp != NULL
- *             self.owns_samfile = True
- */
-    __pyx_t_2 = PyObject_GetAttr(__pyx_v_store, __pyx_n_s__release); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1254; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __pyx_t_1 = PyObject_Call(__pyx_t_2, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1254; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-
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- *             self.fp = samopen( samfile._filename, mode, NULL )
- *             store.release()
- *             assert self.fp != NULL             # <<<<<<<<<<<<<<
- *             self.owns_samfile = True
- *         else:
- */
-    #ifndef PYREX_WITHOUT_ASSERTIONS
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-    }
-    #endif
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1256
- *             store.release()
- *             assert self.fp != NULL
- *             self.owns_samfile = True             # <<<<<<<<<<<<<<
- *         else:
- *             self.fp = self.samfile.samfile
- */
-    ((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->owns_samfile = 1;
-    goto __pyx_L9;
-  }
-  /*else*/ {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1258
- *             self.owns_samfile = True
- *         else:
- *             self.fp = self.samfile.samfile             # <<<<<<<<<<<<<<
- *             self.owns_samfile = False
- * 
- */
-    ((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->fp = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)__pyx_v_self)->samfile->samfile;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1259
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- *         if not samfile._isOpen():
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- * 
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- *             raise ValueError( "I/O operation on closed file" )
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- *             raise ValueError( "I/O operation on closed file" )
- * 
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- *         mode = "rb"
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-  __pyx_t_9csamtools___iterdata *__pyx_v_d;
-  int __pyx_r;
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("__advance_all");
-  __Pyx_TraceCall("__advance_all", __pyx_f[0], 1486);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1490
- *     '''
- *     cdef __iterdata * d
- *     d = <__iterdata*>data             # <<<<<<<<<<<<<<
- *     return bam_iter_read( d.samfile.x.bam, d.iter, b )
- * 
- */
-  __pyx_v_d = ((__pyx_t_9csamtools___iterdata *)__pyx_v_data);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1491
- *     cdef __iterdata * d
- *     d = <__iterdata*>data
- *     return bam_iter_read( d.samfile.x.bam, d.iter, b )             # <<<<<<<<<<<<<<
- * 
- * cdef int __advance_snpcalls( void * data, bam1_t * b ):
- */
-  __pyx_r = bam_iter_read(__pyx_v_d->samfile->x.bam, __pyx_v_d->iter, __pyx_v_b);
-  goto __pyx_L0;
-
-  __pyx_r = 0;
-  __pyx_L0:;
-  __Pyx_TraceReturn(Py_None);
-  __Pyx_RefNannyFinishContext();
-  return __pyx_r;
-}
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1493
- *     return bam_iter_read( d.samfile.x.bam, d.iter, b )
- * 
- * cdef int __advance_snpcalls( void * data, bam1_t * b ):             # <<<<<<<<<<<<<<
- *     '''advance using same filter and read processing as in
- *     the samtools pileup.
- */
-
-static  int __pyx_f_9csamtools___advance_snpcalls(void *__pyx_v_data, bam1_t *__pyx_v_b) {
-  __pyx_t_9csamtools___iterdata *__pyx_v_d;
-  int __pyx_v_ret;
-  int __pyx_v_skip;
-  int __pyx_v_q;
-  int __pyx_v_is_cns;
-  int __pyx_v_is_nobaq;
-  int __pyx_v_capQ_thres;
-  int __pyx_r;
-  int __pyx_t_1;
-  int __pyx_t_2;
-  int __pyx_t_3;
-  PyObject *__pyx_t_4 = NULL;
-  PyObject *__pyx_t_5 = NULL;
-  PyObject *__pyx_t_6 = NULL;
-  long __pyx_t_7;
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("__advance_snpcalls");
-  __Pyx_TraceCall("__advance_snpcalls", __pyx_f[0], 1493);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1498
- *     '''
- *     cdef __iterdata * d
- *     d = <__iterdata*>data             # <<<<<<<<<<<<<<
- * 
- *     cdef int ret = bam_iter_read( d.samfile.x.bam, d.iter, b )
- */
-  __pyx_v_d = ((__pyx_t_9csamtools___iterdata *)__pyx_v_data);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1500
- *     d = <__iterdata*>data
- * 
- *     cdef int ret = bam_iter_read( d.samfile.x.bam, d.iter, b )             # <<<<<<<<<<<<<<
- *     cdef int skip = 0
- *     cdef int q
- */
-  __pyx_v_ret = bam_iter_read(__pyx_v_d->samfile->x.bam, __pyx_v_d->iter, __pyx_v_b);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1501
- * 
- *     cdef int ret = bam_iter_read( d.samfile.x.bam, d.iter, b )
- *     cdef int skip = 0             # <<<<<<<<<<<<<<
- *     cdef int q
- *     cdef int is_cns = 1
- */
-  __pyx_v_skip = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1503
- *     cdef int skip = 0
- *     cdef int q
- *     cdef int is_cns = 1             # <<<<<<<<<<<<<<
- *     cdef int is_nobaq = 0
- *     cdef int capQ_thres = 0
- */
-  __pyx_v_is_cns = 1;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1504
- *     cdef int q
- *     cdef int is_cns = 1
- *     cdef int is_nobaq = 0             # <<<<<<<<<<<<<<
- *     cdef int capQ_thres = 0
- * 
- */
-  __pyx_v_is_nobaq = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1505
- *     cdef int is_cns = 1
- *     cdef int is_nobaq = 0
- *     cdef int capQ_thres = 0             # <<<<<<<<<<<<<<
- * 
- *     # reload sequence
- */
-  __pyx_v_capQ_thres = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1508
- * 
- *     # reload sequence
- *     if d.fastafile != NULL and b.core.tid != d.tid:             # <<<<<<<<<<<<<<
- *         if d.seq != NULL: free(d.seq)
- *         d.tid = b.core.tid
- */
-  __pyx_t_1 = (__pyx_v_d->fastafile != NULL);
-  if (__pyx_t_1) {
-    __pyx_t_2 = (__pyx_v_b->core.tid != __pyx_v_d->tid);
-    __pyx_t_3 = __pyx_t_2;
-  } else {
-    __pyx_t_3 = __pyx_t_1;
-  }
-  if (__pyx_t_3) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1509
- *     # reload sequence
- *     if d.fastafile != NULL and b.core.tid != d.tid:
- *         if d.seq != NULL: free(d.seq)             # <<<<<<<<<<<<<<
- *         d.tid = b.core.tid
- *         d.seq = faidx_fetch_seq(d.fastafile,
- */
-    __pyx_t_3 = (__pyx_v_d->seq != NULL);
-    if (__pyx_t_3) {
-      free(__pyx_v_d->seq);
-      goto __pyx_L4;
-    }
-    __pyx_L4:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1510
- *     if d.fastafile != NULL and b.core.tid != d.tid:
- *         if d.seq != NULL: free(d.seq)
- *         d.tid = b.core.tid             # <<<<<<<<<<<<<<
- *         d.seq = faidx_fetch_seq(d.fastafile,
- *                                 d.samfile.header.target_name[d.tid],
- */
-    __pyx_v_d->tid = __pyx_v_b->core.tid;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1511
- *         if d.seq != NULL: free(d.seq)
- *         d.tid = b.core.tid
- *         d.seq = faidx_fetch_seq(d.fastafile,             # <<<<<<<<<<<<<<
- *                                 d.samfile.header.target_name[d.tid],
- *                                 0, max_pos,
- */
-    __pyx_v_d->seq = faidx_fetch_seq(__pyx_v_d->fastafile, (__pyx_v_d->samfile->header->target_name[__pyx_v_d->tid]), 0, __pyx_v_9csamtools_max_pos, (&__pyx_v_d->seq_len));
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1515
- *                                 0, max_pos,
- *                                 &d.seq_len)
- *         if d.seq == NULL:             # <<<<<<<<<<<<<<
- *             raise ValueError( "reference sequence for '%s' (tid=%i) not found" % \
- *                                   (d.samfile.header.target_name[d.tid],
- */
-    __pyx_t_3 = (__pyx_v_d->seq == NULL);
-    if (__pyx_t_3) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1517
- *         if d.seq == NULL:
- *             raise ValueError( "reference sequence for '%s' (tid=%i) not found" % \
- *                                   (d.samfile.header.target_name[d.tid],             # <<<<<<<<<<<<<<
- *                                    d.tid))
- * 
- */
-      __pyx_t_4 = PyBytes_FromString((__pyx_v_d->samfile->header->target_name[__pyx_v_d->tid])); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1517; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_4));
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1518
- *             raise ValueError( "reference sequence for '%s' (tid=%i) not found" % \
- *                                   (d.samfile.header.target_name[d.tid],
- *                                    d.tid))             # <<<<<<<<<<<<<<
- * 
- * 
- */
-      __pyx_t_5 = PyInt_FromLong(__pyx_v_d->tid); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1518; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_5);
-      __pyx_t_6 = PyTuple_New(2); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1517; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_6);
-      PyTuple_SET_ITEM(__pyx_t_6, 0, ((PyObject *)__pyx_t_4));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_4));
-      PyTuple_SET_ITEM(__pyx_t_6, 1, __pyx_t_5);
-      __Pyx_GIVEREF(__pyx_t_5);
-      __pyx_t_4 = 0;
-      __pyx_t_5 = 0;
-      __pyx_t_5 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_56), __pyx_t_6); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1516; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_5));
-      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
-      __pyx_t_6 = PyTuple_New(1); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1516; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_6);
-      PyTuple_SET_ITEM(__pyx_t_6, 0, ((PyObject *)__pyx_t_5));
-      __Pyx_GIVEREF(((PyObject *)__pyx_t_5));
-      __pyx_t_5 = 0;
-      __pyx_t_5 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_6, NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1516; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_5);
-      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
-      __Pyx_Raise(__pyx_t_5, 0, 0);
-      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-      {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1516; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      goto __pyx_L5;
-    }
-    __pyx_L5:;
-    goto __pyx_L3;
-  }
-  __pyx_L3:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1521
- * 
- * 
- *     while ret >= 0:             # <<<<<<<<<<<<<<
- * 
- *         skip = 0
- */
-  while (1) {
-    __pyx_t_3 = (__pyx_v_ret >= 0);
-    if (!__pyx_t_3) break;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1523
- *     while ret >= 0:
- * 
- *         skip = 0             # <<<<<<<<<<<<<<
- * 
- *         # realign read - changes base qualities
- */
-    __pyx_v_skip = 0;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1526
- * 
- *         # realign read - changes base qualities
- *         if d.seq != NULL and is_cns and not is_nobaq: bam_prob_realn( b, d.seq )             # <<<<<<<<<<<<<<
- * 
- *         if d.seq != NULL and capQ_thres > 10:
- */
-    __pyx_t_3 = (__pyx_v_d->seq != NULL);
-    if (__pyx_t_3) {
-      if (__pyx_v_is_cns) {
-        __pyx_t_1 = (!__pyx_v_is_nobaq);
-        __pyx_t_2 = __pyx_t_1;
-      } else {
-        __pyx_t_2 = __pyx_v_is_cns;
-      }
-      __pyx_t_1 = __pyx_t_2;
-    } else {
-      __pyx_t_1 = __pyx_t_3;
-    }
-    if (__pyx_t_1) {
-      bam_prob_realn(__pyx_v_b, __pyx_v_d->seq);
-      goto __pyx_L8;
-    }
-    __pyx_L8:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1528
- *         if d.seq != NULL and is_cns and not is_nobaq: bam_prob_realn( b, d.seq )
- * 
- *         if d.seq != NULL and capQ_thres > 10:             # <<<<<<<<<<<<<<
- *             q = bam_cap_mapQ(b, d.seq, capQ_thres)
- *             if q < 0: skip = 1
- */
-    __pyx_t_1 = (__pyx_v_d->seq != NULL);
-    if (__pyx_t_1) {
-      __pyx_t_3 = (__pyx_v_capQ_thres > 10);
-      __pyx_t_2 = __pyx_t_3;
-    } else {
-      __pyx_t_2 = __pyx_t_1;
-    }
-    if (__pyx_t_2) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1529
- * 
- *         if d.seq != NULL and capQ_thres > 10:
- *             q = bam_cap_mapQ(b, d.seq, capQ_thres)             # <<<<<<<<<<<<<<
- *             if q < 0: skip = 1
- *             elif b.core.qual > q: b.core.qual = q
- */
-      __pyx_v_q = bam_cap_mapQ(__pyx_v_b, __pyx_v_d->seq, __pyx_v_capQ_thres);
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1530
- *         if d.seq != NULL and capQ_thres > 10:
- *             q = bam_cap_mapQ(b, d.seq, capQ_thres)
- *             if q < 0: skip = 1             # <<<<<<<<<<<<<<
- *             elif b.core.qual > q: b.core.qual = q
- *         if b.core.flag & BAM_FUNMAP: skip = 1
- */
-      __pyx_t_2 = (__pyx_v_q < 0);
-      if (__pyx_t_2) {
-        __pyx_v_skip = 1;
-        goto __pyx_L10;
-      }
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1531
- *             q = bam_cap_mapQ(b, d.seq, capQ_thres)
- *             if q < 0: skip = 1
- *             elif b.core.qual > q: b.core.qual = q             # <<<<<<<<<<<<<<
- *         if b.core.flag & BAM_FUNMAP: skip = 1
- *         elif b.core.flag & 1 and not b.core.flag & 2: skip = 1
- */
-      __pyx_t_2 = (__pyx_v_b->core.qual > __pyx_v_q);
-      if (__pyx_t_2) {
-        __pyx_v_b->core.qual = __pyx_v_q;
-        goto __pyx_L10;
-      }
-      __pyx_L10:;
-      goto __pyx_L9;
-    }
-    __pyx_L9:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1532
- *             if q < 0: skip = 1
- *             elif b.core.qual > q: b.core.qual = q
- *         if b.core.flag & BAM_FUNMAP: skip = 1             # <<<<<<<<<<<<<<
- *         elif b.core.flag & 1 and not b.core.flag & 2: skip = 1
- * 
- */
-    __pyx_t_7 = (__pyx_v_b->core.flag & 4);
-    if (__pyx_t_7) {
-      __pyx_v_skip = 1;
-      goto __pyx_L11;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1533
- *             elif b.core.qual > q: b.core.qual = q
- *         if b.core.flag & BAM_FUNMAP: skip = 1
- *         elif b.core.flag & 1 and not b.core.flag & 2: skip = 1             # <<<<<<<<<<<<<<
- * 
- *         if not skip: break
- */
-    if ((__pyx_v_b->core.flag & 1)) {
-      __pyx_t_2 = (!(__pyx_v_b->core.flag & 2));
-      __pyx_t_1 = __pyx_t_2;
-    } else {
-      __pyx_t_1 = (__pyx_v_b->core.flag & 1);
-    }
-    if (__pyx_t_1) {
-      __pyx_v_skip = 1;
-      goto __pyx_L11;
-    }
-    __pyx_L11:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1535
- *         elif b.core.flag & 1 and not b.core.flag & 2: skip = 1
- * 
- *         if not skip: break             # <<<<<<<<<<<<<<
- *         # additional filters
- * 
- */
-    __pyx_t_1 = (!__pyx_v_skip);
-    if (__pyx_t_1) {
-      goto __pyx_L7_break;
-      goto __pyx_L12;
-    }
-    __pyx_L12:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1538
- *         # additional filters
- * 
- *         ret = bam_iter_read( d.samfile.x.bam, d.iter, b )             # <<<<<<<<<<<<<<
- * 
- *     return ret
- */
-    __pyx_v_ret = bam_iter_read(__pyx_v_d->samfile->x.bam, __pyx_v_d->iter, __pyx_v_b);
-  }
-  __pyx_L7_break:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1540
- *         ret = bam_iter_read( d.samfile.x.bam, d.iter, b )
- * 
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- *     cdef uint32_t k
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- *     if src.core.n_cigar:             # <<<<<<<<<<<<<<
- *         cigar_p = bam1_cigar(src);
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-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1790
- *         cigar_p = bam1_cigar(src);
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- *             op = cigar_p[k] & BAM_CIGAR_MASK             # <<<<<<<<<<<<<<
- *             if op==BAM_CHARD_CLIP:
- *                 if start_offset!=0 and start_offset!=src.core.l_qseq:
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-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1791
- *         for k from 0 <= k < src.core.n_cigar:
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- *             if op==BAM_CHARD_CLIP:             # <<<<<<<<<<<<<<
- *                 if start_offset!=0 and start_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
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-      switch (__pyx_v_op) {
-        case 5:
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-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1792
- *             op = cigar_p[k] & BAM_CIGAR_MASK
- *             if op==BAM_CHARD_CLIP:
- *                 if start_offset!=0 and start_offset!=src.core.l_qseq:             # <<<<<<<<<<<<<<
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1
- */
-        __pyx_t_2 = (__pyx_v_start_offset != 0);
-        if (__pyx_t_2) {
-          __pyx_t_3 = (__pyx_v_start_offset != __pyx_v_src->core.l_qseq);
-          __pyx_t_4 = __pyx_t_3;
-        } else {
-          __pyx_t_4 = __pyx_t_2;
-        }
-        if (__pyx_t_4) {
-
-          /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1793
- *             if op==BAM_CHARD_CLIP:
- *                 if start_offset!=0 and start_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')             # <<<<<<<<<<<<<<
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:
- */
-          PyErr_SetString(__pyx_builtin_ValueError, __pyx_k_60);
-
-          /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1794
- *                 if start_offset!=0 and start_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1             # <<<<<<<<<<<<<<
- *             elif op==BAM_CSOFT_CLIP:
- *                 start_offset += cigar_p[k] >> BAM_CIGAR_SHIFT
- */
-          __pyx_r = -1;
-          goto __pyx_L0;
-          goto __pyx_L6;
-        }
-        __pyx_L6:;
-        break;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1795
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:             # <<<<<<<<<<<<<<
- *                 start_offset += cigar_p[k] >> BAM_CIGAR_SHIFT
- *             else:
- */
-        case 4:
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1796
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:
- *                 start_offset += cigar_p[k] >> BAM_CIGAR_SHIFT             # <<<<<<<<<<<<<<
- *             else:
- *                 break
- */
-        __pyx_v_start_offset += ((__pyx_v_cigar_p[__pyx_v_k]) >> 4);
-        break;
-        default:
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1798
- *                 start_offset += cigar_p[k] >> BAM_CIGAR_SHIFT
- *             else:
- *                 break             # <<<<<<<<<<<<<<
- * 
- *     return start_offset
- */
-        goto __pyx_L5_break;
-        break;
-      }
-    }
-    __pyx_L5_break:;
-    goto __pyx_L3;
-  }
-  __pyx_L3:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1800
- *                 break
- * 
- *     return start_offset             # <<<<<<<<<<<<<<
- * 
- * ##-------------------------------------------------------------------
- */
-  __pyx_r = __pyx_v_start_offset;
-  goto __pyx_L0;
-
-  __pyx_r = 0;
-  __pyx_L0:;
-  __Pyx_TraceReturn(Py_None);
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-  return __pyx_r;
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- * ##-------------------------------------------------------------------
- * ##-------------------------------------------------------------------
- * cdef inline int32_t query_end(bam1_t *src) except -1:             # <<<<<<<<<<<<<<
- *     cdef uint32_t * cigar_p, op
- *     cdef uint32_t k
- */
-
-static CYTHON_INLINE int32_t __pyx_f_9csamtools_query_end(bam1_t *__pyx_v_src) {
-  uint32_t *__pyx_v_cigar_p;
-  uint32_t __pyx_v_op;
-  uint32_t __pyx_v_k;
-  uint32_t __pyx_v_end_offset;
-  int32_t __pyx_r;
-  int __pyx_t_1;
-  int __pyx_t_2;
-  int __pyx_t_3;
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("query_end");
-  __Pyx_TraceCall("query_end", __pyx_f[0], 1805);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1808
- *     cdef uint32_t * cigar_p, op
- *     cdef uint32_t k
- *     cdef uint32_t end_offset = src.core.l_qseq             # <<<<<<<<<<<<<<
- * 
- *     if src.core.n_cigar>1:
- */
-  __pyx_v_end_offset = __pyx_v_src->core.l_qseq;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1810
- *     cdef uint32_t end_offset = src.core.l_qseq
- * 
- *     if src.core.n_cigar>1:             # <<<<<<<<<<<<<<
- *         cigar_p = bam1_cigar(src);
- *         for k from src.core.n_cigar > k >= 1:
- */
-  __pyx_t_1 = (__pyx_v_src->core.n_cigar > 1);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1811
- * 
- *     if src.core.n_cigar>1:
- *         cigar_p = bam1_cigar(src);             # <<<<<<<<<<<<<<
- *         for k from src.core.n_cigar > k >= 1:
- *             op = cigar_p[k] & BAM_CIGAR_MASK
- */
-    __pyx_v_cigar_p = bam1_cigar(__pyx_v_src);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1812
- *     if src.core.n_cigar>1:
- *         cigar_p = bam1_cigar(src);
- *         for k from src.core.n_cigar > k >= 1:             # <<<<<<<<<<<<<<
- *             op = cigar_p[k] & BAM_CIGAR_MASK
- *             if op==BAM_CHARD_CLIP:
- */
-    for (__pyx_v_k = __pyx_v_src->core.n_cigar-1; __pyx_v_k >= 1; __pyx_v_k--) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1813
- *         cigar_p = bam1_cigar(src);
- *         for k from src.core.n_cigar > k >= 1:
- *             op = cigar_p[k] & BAM_CIGAR_MASK             # <<<<<<<<<<<<<<
- *             if op==BAM_CHARD_CLIP:
- *                 if end_offset!=0 and end_offset!=src.core.l_qseq:
- */
-      __pyx_v_op = ((__pyx_v_cigar_p[__pyx_v_k]) & 15);
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1814
- *         for k from src.core.n_cigar > k >= 1:
- *             op = cigar_p[k] & BAM_CIGAR_MASK
- *             if op==BAM_CHARD_CLIP:             # <<<<<<<<<<<<<<
- *                 if end_offset!=0 and end_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
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-      switch (__pyx_v_op) {
-        case 5:
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1815
- *             op = cigar_p[k] & BAM_CIGAR_MASK
- *             if op==BAM_CHARD_CLIP:
- *                 if end_offset!=0 and end_offset!=src.core.l_qseq:             # <<<<<<<<<<<<<<
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1
- */
-        __pyx_t_1 = (__pyx_v_end_offset != 0);
-        if (__pyx_t_1) {
-          __pyx_t_2 = (__pyx_v_end_offset != __pyx_v_src->core.l_qseq);
-          __pyx_t_3 = __pyx_t_2;
-        } else {
-          __pyx_t_3 = __pyx_t_1;
-        }
-        if (__pyx_t_3) {
-
-          /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1816
- *             if op==BAM_CHARD_CLIP:
- *                 if end_offset!=0 and end_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')             # <<<<<<<<<<<<<<
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:
- */
-          PyErr_SetString(__pyx_builtin_ValueError, __pyx_k_60);
-
-          /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1817
- *                 if end_offset!=0 and end_offset!=src.core.l_qseq:
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1             # <<<<<<<<<<<<<<
- *             elif op==BAM_CSOFT_CLIP:
- *                 end_offset -= cigar_p[k] >> BAM_CIGAR_SHIFT
- */
-          __pyx_r = -1;
-          goto __pyx_L0;
-          goto __pyx_L6;
-        }
-        __pyx_L6:;
-        break;
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1818
- *                     PyErr_SetString(ValueError, 'Invalid clipping in CIGAR string')
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:             # <<<<<<<<<<<<<<
- *                 end_offset -= cigar_p[k] >> BAM_CIGAR_SHIFT
- *             else:
- */
-        case 4:
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1819
- *                     return -1
- *             elif op==BAM_CSOFT_CLIP:
- *                 end_offset -= cigar_p[k] >> BAM_CIGAR_SHIFT             # <<<<<<<<<<<<<<
- *             else:
- *                 break
- */
-        __pyx_v_end_offset -= ((__pyx_v_cigar_p[__pyx_v_k]) >> 4);
-        break;
-        default:
-
-        /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1821
- *                 end_offset -= cigar_p[k] >> BAM_CIGAR_SHIFT
- *             else:
- *                 break             # <<<<<<<<<<<<<<
- * 
- *     if end_offset==0:
- */
-        goto __pyx_L5_break;
-        break;
-      }
-    }
-    __pyx_L5_break:;
-    goto __pyx_L3;
-  }
-  __pyx_L3:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1823
- *                 break
- * 
- *     if end_offset==0:             # <<<<<<<<<<<<<<
- *         end_offset = src.core.l_qseq
- * 
- */
-  __pyx_t_3 = (__pyx_v_end_offset == 0);
-  if (__pyx_t_3) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1824
- * 
- *     if end_offset==0:
- *         end_offset = src.core.l_qseq             # <<<<<<<<<<<<<<
- * 
- *     return end_offset
- */
-    __pyx_v_end_offset = __pyx_v_src->core.l_qseq;
-    goto __pyx_L7;
-  }
-  __pyx_L7:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1826
- *         end_offset = src.core.l_qseq
- * 
- *     return end_offset             # <<<<<<<<<<<<<<
- * 
- * 
- */
-  __pyx_r = __pyx_v_end_offset;
-  goto __pyx_L0;
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-  __pyx_r = 0;
-  __pyx_L0:;
-  __Pyx_TraceReturn(Py_None);
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-  return __pyx_r;
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- * 
- * 
- * cdef inline object get_seq_range(bam1_t *src, uint32_t start, uint32_t end):             # <<<<<<<<<<<<<<
- *     cdef uint8_t * p
- *     cdef uint32_t k
- */
-
-static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_seq_range(bam1_t *__pyx_v_src, uint32_t __pyx_v_start, uint32_t __pyx_v_end) {
-  uint8_t *__pyx_v_p;
-  uint32_t __pyx_v_k;
-  char *__pyx_v_s;
-  PyObject *__pyx_v_seq;
-  PyObject *__pyx_r = NULL;
-  int __pyx_t_1;
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-  uint32_t __pyx_t_3;
-  __Pyx_TraceDeclarations
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1834
- *     cdef char * s
- * 
- *     if not src.core.l_qseq:             # <<<<<<<<<<<<<<
- *         return None
- * 
- */
-  __pyx_t_1 = (!__pyx_v_src->core.l_qseq);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1835
- * 
- *     if not src.core.l_qseq:
- *         return None             # <<<<<<<<<<<<<<
- * 
- *     seq = PyString_FromStringAndSize(NULL, end-start)
- */
-    __Pyx_XDECREF(__pyx_r);
-    __Pyx_INCREF(Py_None);
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-  __pyx_L3:;
-
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- *         return None
- * 
- *     seq = PyString_FromStringAndSize(NULL, end-start)             # <<<<<<<<<<<<<<
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-  __pyx_t_2 = PyString_FromStringAndSize(NULL, (__pyx_v_end - __pyx_v_start)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1837; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_v_seq);
-  __pyx_v_seq = __pyx_t_2;
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-
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- * 
- *     seq = PyString_FromStringAndSize(NULL, end-start)
- *     s   = PyString_AS_STRING(seq)             # <<<<<<<<<<<<<<
- *     p   = bam1_seq(src)
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-  __pyx_v_s = PyString_AS_STRING(__pyx_v_seq);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1839
- *     seq = PyString_FromStringAndSize(NULL, end-start)
- *     s   = PyString_AS_STRING(seq)
- *     p   = bam1_seq(src)             # <<<<<<<<<<<<<<
- * 
- *     for k from start <= k < end:
- */
-  __pyx_v_p = bam1_seq(__pyx_v_src);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1841
- *     p   = bam1_seq(src)
- * 
- *     for k from start <= k < end:             # <<<<<<<<<<<<<<
- *         # equivalent to bam_nt16_rev_table[bam1_seqi(s, i)] (see bam.c)
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-
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- *         # equivalent to bam_nt16_rev_table[bam1_seqi(s, i)] (see bam.c)
- *         # note: do not use string literal as it will be a python string
- *         s[k-start] = bam_nt16_rev_table[p[k/2] >> 4 * (1 - k%2) & 0xf]             # <<<<<<<<<<<<<<
- * 
- *     return seq
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1846
- *         s[k-start] = bam_nt16_rev_table[p[k/2] >> 4 * (1 - k%2) & 0xf]
- * 
- *     return seq             # <<<<<<<<<<<<<<
- * 
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-  __Pyx_INCREF(__pyx_v_seq);
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-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
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-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_2);
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- * 
- * 
- * cdef inline object get_qual_range(bam1_t *src, uint32_t start, uint32_t end):             # <<<<<<<<<<<<<<
- *     cdef uint8_t * p
- *     cdef uint32_t k
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-
-static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_qual_range(bam1_t *__pyx_v_src, uint32_t __pyx_v_start, uint32_t __pyx_v_end) {
-  uint8_t *__pyx_v_p;
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1854
- *     cdef char * q
- * 
- *     p = bam1_qual(src)             # <<<<<<<<<<<<<<
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- *         return None
- */
-  __pyx_v_p = bam1_qual(__pyx_v_src);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1855
- * 
- *     p = bam1_qual(src)
- *     if p[0] == 0xff:             # <<<<<<<<<<<<<<
- *         return None
- * 
- */
-  __pyx_t_1 = ((__pyx_v_p[0]) == 0xff);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1856
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- *         return None             # <<<<<<<<<<<<<<
- * 
- *     qual = PyString_FromStringAndSize(NULL, end-start)
- */
-    __Pyx_XDECREF(__pyx_r);
-    __Pyx_INCREF(Py_None);
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-    goto __pyx_L0;
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-  __pyx_L3:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1858
- *         return None
- * 
- *     qual = PyString_FromStringAndSize(NULL, end-start)             # <<<<<<<<<<<<<<
- *     q    = PyString_AS_STRING(qual)
- * 
- */
-  __pyx_t_2 = PyString_FromStringAndSize(NULL, (__pyx_v_end - __pyx_v_start)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1858; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_v_qual);
-  __pyx_v_qual = __pyx_t_2;
-  __pyx_t_2 = 0;
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- * 
- *     qual = PyString_FromStringAndSize(NULL, end-start)
- *     q    = PyString_AS_STRING(qual)             # <<<<<<<<<<<<<<
- * 
- *     for k from start <= k < end:
- */
-  __pyx_v_q = PyString_AS_STRING(__pyx_v_qual);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1861
- *     q    = PyString_AS_STRING(qual)
- * 
- *     for k from start <= k < end:             # <<<<<<<<<<<<<<
- *         ## equivalent to t[i] + 33 (see bam.c)
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- */
-  __pyx_t_3 = __pyx_v_end;
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1863
- *     for k from start <= k < end:
- *         ## equivalent to t[i] + 33 (see bam.c)
- *         q[k-start] = p[k] + 33             # <<<<<<<<<<<<<<
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- *                               src.core.l_qname,
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- *             # as it might have moved
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1991
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- *             strncpy( p, qname, l )             # <<<<<<<<<<<<<<
- * 
- *     property cigar:
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-  __pyx_t_6 = PyBytes_AsString(__pyx_v_qname); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1991; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  strncpy(__pyx_v_p, __pyx_t_6, __pyx_v_l);
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- *         def __get__(self):             # <<<<<<<<<<<<<<
- *             cdef uint32_t * cigar_p
- *             cdef bam1_t * src
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-
-static PyObject *__pyx_pf_9csamtools_11AlignedRead_5cigar___get__(PyObject *__pyx_v_self); /*proto*/
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-  uint32_t *__pyx_v_cigar_p;
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- *             cdef int k
- * 
- *             src = self._delegate             # <<<<<<<<<<<<<<
- *             if src.core.n_cigar == 0: return None
- * 
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- * 
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- *             if src.core.n_cigar == 0: return None
- * 
- *             cigar = []             # <<<<<<<<<<<<<<
- *             cigar_p = bam1_cigar(src);
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2006
- * 
- *             cigar = []
- *             cigar_p = bam1_cigar(src);             # <<<<<<<<<<<<<<
- *             for k from 0 <= k < src.core.n_cigar:
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- *             cigar = []
- *             cigar_p = bam1_cigar(src);
- *             for k from 0 <= k < src.core.n_cigar:             # <<<<<<<<<<<<<<
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-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2008
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- *             for k from 0 <= k < src.core.n_cigar:
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- *                 cigar.append((op, l))
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- *             return cigar
- * 
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- *                 l = cigar_p[k] >> BAM_CIGAR_SHIFT
- *                 cigar.append((op, l))
- *             return cigar             # <<<<<<<<<<<<<<
- * 
- *         def __set__(self, values ):
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-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
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-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_2);
-  __Pyx_XDECREF(__pyx_t_4);
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-  __Pyx_DECREF(__pyx_v_cigar);
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- * 
- *         def __set__(self, values ):             # <<<<<<<<<<<<<<
- *             if values == None or len(values) == 0: return
- *             cdef uint32_t * p
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-
-static int __pyx_pf_9csamtools_11AlignedRead_5cigar___set__(PyObject *__pyx_v_self, PyObject *__pyx_v_values); /*proto*/
-static int __pyx_pf_9csamtools_11AlignedRead_5cigar___set__(PyObject *__pyx_v_self, PyObject *__pyx_v_values) {
-  uint32_t *__pyx_v_p;
-  bam1_t *__pyx_v_src;
-  PyObject *__pyx_v_op;
-  PyObject *__pyx_v_l;
-  int __pyx_v_k;
-  int __pyx_r;
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-  PyObject *__pyx_t_6 = NULL;
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- * 
- *         def __set__(self, values ):
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- *             cdef uint32_t * p
- *             cdef bam1_t * src
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-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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-    goto __pyx_L5;
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-  __pyx_L5:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2020
- *             cdef int k
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- *             k = 0             # <<<<<<<<<<<<<<
- * 
- *             src = self._delegate
- */
-  __pyx_v_k = 0;
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2022
- *             k = 0
- * 
- *             src = self._delegate             # <<<<<<<<<<<<<<
- * 
- *             # get location of cigar string
- */
-  __pyx_v_src = ((struct __pyx_obj_9csamtools_AlignedRead *)__pyx_v_self)->_delegate;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2025
- * 
- *             # get location of cigar string
- *             p = bam1_cigar(src)             # <<<<<<<<<<<<<<
- * 
- *             # create space for cigar data within src.data
- */
-  __pyx_v_p = bam1_cigar(__pyx_v_src);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2030
- *             pysam_bam_update( src,
- *                               src.core.n_cigar * 4,
- *                               len(values) * 4,             # <<<<<<<<<<<<<<
- *                               <uint8_t*>p )
- * 
- */
-  __pyx_t_3 = PyObject_Length(__pyx_v_values); if (unlikely(__pyx_t_3 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2030; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2031
- *                               src.core.n_cigar * 4,
- *                               len(values) * 4,
- *                               <uint8_t*>p )             # <<<<<<<<<<<<<<
- * 
- *             # length is number of cigar operations, not bytes
- */
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2034
- * 
- *             # length is number of cigar operations, not bytes
- *             src.core.n_cigar = len(values)             # <<<<<<<<<<<<<<
- * 
- *             # re-acquire pointer to location in memory
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-  __pyx_v_src->core.n_cigar = __pyx_t_3;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2038
- *             # re-acquire pointer to location in memory
- *             # as it might have moved
- *             p = bam1_cigar(src)             # <<<<<<<<<<<<<<
- * 
- *             # insert cigar operations
- */
-  __pyx_v_p = bam1_cigar(__pyx_v_src);
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2041
- * 
- *             # insert cigar operations
- *             for op, l in values:             # <<<<<<<<<<<<<<
- *                 p[k] = l << BAM_CIGAR_SHIFT | op
- *                 k += 1
- */
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-    __Pyx_GOTREF(__pyx_t_1);
-  }
-  for (;;) {
-    if (likely(PyList_CheckExact(__pyx_t_1))) {
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-    } else if (likely(PyTuple_CheckExact(__pyx_t_1))) {
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-    } else {
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- *         def __get__(self):             # <<<<<<<<<<<<<<
- *             cdef bam1_t * src
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-static PyObject *__pyx_pf_9csamtools_11AlignedRead_3seq___get__(PyObject *__pyx_v_self); /*proto*/
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- * 
- *             return get_seq_range(src, 0, src.core.l_qseq)             # <<<<<<<<<<<<<<
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- *         def __set__(self,seq):
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- * 
- *         def __set__(self,seq):             # <<<<<<<<<<<<<<
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-static int __pyx_pf_9csamtools_11AlignedRead_3seq___set__(PyObject *__pyx_v_self, PyObject *__pyx_v_seq); /*proto*/
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- *             cdef bam1_t * src
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- * 
- *             src = self._delegate             # <<<<<<<<<<<<<<
- * 
- *             l = len(seq)
- */
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- *             src = self._delegate
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- *             l = len(seq)             # <<<<<<<<<<<<<<
- * 
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- *             # as the sequence is stored in half-bytes, the total length (sequence
- *             # plus quality scores) is (l+1)/2 + l
- *             nbytes_new = (l+1)/2 + l             # <<<<<<<<<<<<<<
- *             nbytes_old = (src.core.l_qseq+1)/2 + src.core.l_qseq
- *             # acquire pointer to location in memory
- */
-  __pyx_v_nbytes_new = (__Pyx_div_long((__pyx_v_l + 1), 2) + __pyx_v_l);
-
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- *             # plus quality scores) is (l+1)/2 + l
- *             nbytes_new = (l+1)/2 + l
- *             nbytes_old = (src.core.l_qseq+1)/2 + src.core.l_qseq             # <<<<<<<<<<<<<<
- *             # acquire pointer to location in memory
- *             p = bam1_seq( src )
- */
-  __pyx_v_nbytes_old = (__Pyx_div_long((__pyx_v_src->core.l_qseq + 1), 2) + __pyx_v_src->core.l_qseq);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2078
- *             nbytes_old = (src.core.l_qseq+1)/2 + src.core.l_qseq
- *             # acquire pointer to location in memory
- *             p = bam1_seq( src )             # <<<<<<<<<<<<<<
- *             src.core.l_qseq = l
- * 
- */
-  __pyx_v_p = bam1_seq(__pyx_v_src);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2079
- *             # acquire pointer to location in memory
- *             p = bam1_seq( src )
- *             src.core.l_qseq = l             # <<<<<<<<<<<<<<
- * 
- *             pysam_bam_update( src,
- */
-  __pyx_v_src->core.l_qseq = __pyx_v_l;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2084
- *                               nbytes_old,
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- *                               p)             # <<<<<<<<<<<<<<
- *             # re-acquire pointer to location in memory
- *             # as it might have moved
- */
-  pysam_bam_update(__pyx_v_src, __pyx_v_nbytes_old, __pyx_v_nbytes_new, __pyx_v_p);
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- *             # re-acquire pointer to location in memory
- *             # as it might have moved
- *             p = bam1_seq( src )             # <<<<<<<<<<<<<<
- *             for k from 0 <= k < nbytes_new: p[k] = 0
- *             # convert to C string
- */
-  __pyx_v_p = bam1_seq(__pyx_v_src);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2088
- *             # as it might have moved
- *             p = bam1_seq( src )
- *             for k from 0 <= k < nbytes_new: p[k] = 0             # <<<<<<<<<<<<<<
- *             # convert to C string
- *             s = seq
- */
-  __pyx_t_6 = __pyx_v_nbytes_new;
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-    (__pyx_v_p[__pyx_v_k]) = 0;
-  }
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2090
- *             for k from 0 <= k < nbytes_new: p[k] = 0
- *             # convert to C string
- *             s = seq             # <<<<<<<<<<<<<<
- *             for k from 0 <= k < l:
- *                 p[k/2] |= pysam_translate_sequence(s[k]) << 4 * (1 - k % 2)
- */
-  __pyx_t_7 = PyBytes_AsString(__pyx_v_seq); if (unlikely((!__pyx_t_7) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2090; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_v_s = __pyx_t_7;
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- *             # convert to C string
- *             s = seq
- *             for k from 0 <= k < l:             # <<<<<<<<<<<<<<
- *                 p[k/2] |= pysam_translate_sequence(s[k]) << 4 * (1 - k % 2)
- * 
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-  __pyx_t_6 = __pyx_v_l;
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- *             s = seq
- *             for k from 0 <= k < l:
- *                 p[k/2] |= pysam_translate_sequence(s[k]) << 4 * (1 - k % 2)             # <<<<<<<<<<<<<<
- * 
- *             # erase qualities
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- *             # erase qualities
- *             p = bam1_qual( src )             # <<<<<<<<<<<<<<
- *             p[0] = 0xff
- * 
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-  __pyx_v_p = bam1_qual(__pyx_v_src);
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- *             # erase qualities
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- *         def __get__(self):             # <<<<<<<<<<<<<<
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- *             cdef bam1_t * src
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-
-static PyObject *__pyx_pf_9csamtools_11AlignedRead_4qual___get__(PyObject *__pyx_v_self); /*proto*/
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- *         def __set__(self,qual):             # <<<<<<<<<<<<<<
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- *             src = self._delegate             # <<<<<<<<<<<<<<
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-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2123
- *             if qual == None or len(qual) == 0:
- *                 # if absent - set to 0xff
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- *                 p[0] = 0xff
- *                 return             # <<<<<<<<<<<<<<
- *             cdef int l
- *             # convert to C string
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-  __pyx_L5:;
-
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- *             cdef int l
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- *             q = qual             # <<<<<<<<<<<<<<
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-  __pyx_v_q = __pyx_t_6;
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- *             # convert to C string
- *             q = qual
- *             l = len(qual)             # <<<<<<<<<<<<<<
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- *                 raise ValueError("quality and sequence mismatch: %i != %i" % (l, src.core.l_qseq))
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-  __pyx_t_3 = PyObject_Length(__pyx_v_qual); if (unlikely(__pyx_t_3 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2128; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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- *             if src.core.l_qseq != l:             # <<<<<<<<<<<<<<
- *                 raise ValueError("quality and sequence mismatch: %i != %i" % (l, src.core.l_qseq))
- *             assert src.core.l_qseq == l
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- *             l = len(qual)
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- *             assert src.core.l_qseq == l
- *             for k from 0 <= k < l:
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- *                 p[k] = <uint8_t>q[k] - 33
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- *     property query:
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- *                 # get tag
- *                 auxtag[0] = s[0]
- *                 auxtag[1] = s[1]             # <<<<<<<<<<<<<<
- *                 s += 2
- *                 auxtype = s[0]
- */
-    (__pyx_v_auxtag[1]) = (__pyx_v_s[1]);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2221
- *                 auxtag[0] = s[0]
- *                 auxtag[1] = s[1]
- *                 s += 2             # <<<<<<<<<<<<<<
- *                 auxtype = s[0]
- * 
- */
-    __pyx_v_s += 2;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2222
- *                 auxtag[1] = s[1]
- *                 s += 2
- *                 auxtype = s[0]             # <<<<<<<<<<<<<<
- * 
- *                 if auxtype in ('c', 'C'):
- */
-    __pyx_v_auxtype = (__pyx_v_s[0]);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2224
- *                 auxtype = s[0]
- * 
- *                 if auxtype in ('c', 'C'):             # <<<<<<<<<<<<<<
- *                     value = <int>bam_aux2i(s)
- *                     s += 1
- */
-    __pyx_t_3 = __pyx_v_auxtype;
-    __pyx_t_1 = (__pyx_t_3 == 'c');
-    if (!__pyx_t_1) {
-      __pyx_t_4 = (__pyx_t_3 == 'C');
-      __pyx_t_5 = __pyx_t_4;
-    } else {
-      __pyx_t_5 = __pyx_t_1;
-    }
-    __pyx_t_1 = __pyx_t_5;
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2225
- * 
- *                 if auxtype in ('c', 'C'):
- *                     value = <int>bam_aux2i(s)             # <<<<<<<<<<<<<<
- *                     s += 1
- *                 elif auxtype in ('s', 'S'):
- */
-      __pyx_t_2 = PyInt_FromLong(((int)bam_aux2i(__pyx_v_s))); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2225; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = __pyx_t_2;
-      __pyx_t_2 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2226
- *                 if auxtype in ('c', 'C'):
- *                     value = <int>bam_aux2i(s)
- *                     s += 1             # <<<<<<<<<<<<<<
- *                 elif auxtype in ('s', 'S'):
- *                     value = <int>bam_aux2i(s)
- */
-      __pyx_v_s += 1;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2227
- *                     value = <int>bam_aux2i(s)
- *                     s += 1
- *                 elif auxtype in ('s', 'S'):             # <<<<<<<<<<<<<<
- *                     value = <int>bam_aux2i(s)
- *                     s += 2
- */
-    __pyx_t_3 = __pyx_v_auxtype;
-    __pyx_t_1 = (__pyx_t_3 == 's');
-    if (!__pyx_t_1) {
-      __pyx_t_5 = (__pyx_t_3 == 'S');
-      __pyx_t_4 = __pyx_t_5;
-    } else {
-      __pyx_t_4 = __pyx_t_1;
-    }
-    __pyx_t_1 = __pyx_t_4;
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2228
- *                     s += 1
- *                 elif auxtype in ('s', 'S'):
- *                     value = <int>bam_aux2i(s)             # <<<<<<<<<<<<<<
- *                     s += 2
- *                 elif auxtype in ('i', 'I'):
- */
-      __pyx_t_2 = PyInt_FromLong(((int)bam_aux2i(__pyx_v_s))); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = __pyx_t_2;
-      __pyx_t_2 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2229
- *                 elif auxtype in ('s', 'S'):
- *                     value = <int>bam_aux2i(s)
- *                     s += 2             # <<<<<<<<<<<<<<
- *                 elif auxtype in ('i', 'I'):
- *                     value = <float>bam_aux2i(s)
- */
-      __pyx_v_s += 2;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2230
- *                     value = <int>bam_aux2i(s)
- *                     s += 2
- *                 elif auxtype in ('i', 'I'):             # <<<<<<<<<<<<<<
- *                     value = <float>bam_aux2i(s)
- *                     s += 4
- */
-    __pyx_t_3 = __pyx_v_auxtype;
-    __pyx_t_1 = (__pyx_t_3 == 'i');
-    if (!__pyx_t_1) {
-      __pyx_t_4 = (__pyx_t_3 == 'I');
-      __pyx_t_5 = __pyx_t_4;
-    } else {
-      __pyx_t_5 = __pyx_t_1;
-    }
-    __pyx_t_1 = __pyx_t_5;
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2231
- *                     s += 2
- *                 elif auxtype in ('i', 'I'):
- *                     value = <float>bam_aux2i(s)             # <<<<<<<<<<<<<<
- *                     s += 4
- *                 elif auxtype == 'f':
- */
-      __pyx_t_2 = PyFloat_FromDouble(((float)bam_aux2i(__pyx_v_s))); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2231; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = __pyx_t_2;
-      __pyx_t_2 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2232
- *                 elif auxtype in ('i', 'I'):
- *                     value = <float>bam_aux2i(s)
- *                     s += 4             # <<<<<<<<<<<<<<
- *                 elif auxtype == 'f':
- *                     value = <float>bam_aux2f(s)
- */
-      __pyx_v_s += 4;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2233
- *                     value = <float>bam_aux2i(s)
- *                     s += 4
- *                 elif auxtype == 'f':             # <<<<<<<<<<<<<<
- *                     value = <float>bam_aux2f(s)
- *                     s += 4
- */
-    __pyx_t_1 = (__pyx_v_auxtype == 'f');
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2234
- *                     s += 4
- *                 elif auxtype == 'f':
- *                     value = <float>bam_aux2f(s)             # <<<<<<<<<<<<<<
- *                     s += 4
- *                 elif auxtype == 'd':
- */
-      __pyx_t_2 = PyFloat_FromDouble(bam_aux2f(__pyx_v_s)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2234; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = __pyx_t_2;
-      __pyx_t_2 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2235
- *                 elif auxtype == 'f':
- *                     value = <float>bam_aux2f(s)
- *                     s += 4             # <<<<<<<<<<<<<<
- *                 elif auxtype == 'd':
- *                     value = <double>bam_aux2d(s)
- */
-      __pyx_v_s += 4;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2236
- *                     value = <float>bam_aux2f(s)
- *                     s += 4
- *                 elif auxtype == 'd':             # <<<<<<<<<<<<<<
- *                     value = <double>bam_aux2d(s)
- *                     s += 8
- */
-    __pyx_t_1 = (__pyx_v_auxtype == 'd');
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2237
- *                     s += 4
- *                 elif auxtype == 'd':
- *                     value = <double>bam_aux2d(s)             # <<<<<<<<<<<<<<
- *                     s += 8
- *                 elif auxtype == 'A':
- */
-      __pyx_t_2 = PyFloat_FromDouble(bam_aux2d(__pyx_v_s)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = __pyx_t_2;
-      __pyx_t_2 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2238
- *                 elif auxtype == 'd':
- *                     value = <double>bam_aux2d(s)
- *                     s += 8             # <<<<<<<<<<<<<<
- *                 elif auxtype == 'A':
- *                     value = "%c" % <char>bam_aux2A(s)
- */
-      __pyx_v_s += 8;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2239
- *                     value = <double>bam_aux2d(s)
- *                     s += 8
- *                 elif auxtype == 'A':             # <<<<<<<<<<<<<<
- *                     value = "%c" % <char>bam_aux2A(s)
- *                     s += 1
- */
-    __pyx_t_1 = (__pyx_v_auxtype == 'A');
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2240
- *                     s += 8
- *                 elif auxtype == 'A':
- *                     value = "%c" % <char>bam_aux2A(s)             # <<<<<<<<<<<<<<
- *                     s += 1
- *                 elif auxtype in ('Z', 'H'):
- */
-      __pyx_t_2 = PyInt_FromLong(bam_aux2A(__pyx_v_s)); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_2);
-      __pyx_t_6 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_62), __pyx_t_2); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_6));
-      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = ((PyObject *)__pyx_t_6);
-      __pyx_t_6 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2241
- *                 elif auxtype == 'A':
- *                     value = "%c" % <char>bam_aux2A(s)
- *                     s += 1             # <<<<<<<<<<<<<<
- *                 elif auxtype in ('Z', 'H'):
- *                     value = <char*>bam_aux2Z(s)
- */
-      __pyx_v_s += 1;
-      goto __pyx_L8;
-    }
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2242
- *                     value = "%c" % <char>bam_aux2A(s)
- *                     s += 1
- *                 elif auxtype in ('Z', 'H'):             # <<<<<<<<<<<<<<
- *                     value = <char*>bam_aux2Z(s)
- *                     # +1 for NULL terminated string
- */
-    __pyx_t_3 = __pyx_v_auxtype;
-    __pyx_t_1 = (__pyx_t_3 == 'Z');
-    if (!__pyx_t_1) {
-      __pyx_t_5 = (__pyx_t_3 == 'H');
-      __pyx_t_4 = __pyx_t_5;
-    } else {
-      __pyx_t_4 = __pyx_t_1;
-    }
-    __pyx_t_1 = __pyx_t_4;
-    if (__pyx_t_1) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2243
- *                     s += 1
- *                 elif auxtype in ('Z', 'H'):
- *                     value = <char*>bam_aux2Z(s)             # <<<<<<<<<<<<<<
- *                     # +1 for NULL terminated string
- *                     s += len(value) + 1
- */
-      __pyx_t_6 = PyBytes_FromString(bam_aux2Z(__pyx_v_s)); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(((PyObject *)__pyx_t_6));
-      __Pyx_DECREF(__pyx_v_value);
-      __pyx_v_value = ((PyObject *)__pyx_t_6);
-      __pyx_t_6 = 0;
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2245
- *                     value = <char*>bam_aux2Z(s)
- *                     # +1 for NULL terminated string
- *                     s += len(value) + 1             # <<<<<<<<<<<<<<
- *                  #
- *                 s += 1
- */
-      __pyx_t_7 = PyObject_Length(__pyx_v_value); if (unlikely(__pyx_t_7 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2245; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __pyx_v_s += (__pyx_t_7 + 1);
-      goto __pyx_L8;
-    }
-    __pyx_L8:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2247
- *                     s += len(value) + 1
- *                  #
- *                 s += 1             # <<<<<<<<<<<<<<
- * 
- *                 result.append( (auxtag, value) )
- */
-    __pyx_v_s += 1;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2249
- *                 s += 1
- * 
- *                 result.append( (auxtag, value) )             # <<<<<<<<<<<<<<
- * 
- *             return result
- */
-    if (unlikely(__pyx_v_result == Py_None)) {
-      PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2249; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
-    }
-    __pyx_t_6 = PyBytes_FromString(__pyx_v_auxtag); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2249; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_6));
-    __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2249; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_t_6));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_6));
-    __Pyx_INCREF(__pyx_v_value);
-    PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_v_value);
-    __Pyx_GIVEREF(__pyx_v_value);
-    __pyx_t_6 = 0;
-    __pyx_t_8 = PyList_Append(((PyObject *)__pyx_v_result), __pyx_t_2); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2249; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  }
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2251
- *                 result.append( (auxtag, value) )
- * 
- *             return result             # <<<<<<<<<<<<<<
- * 
- *         def __set__(self, tags):
- */
-  __Pyx_XDECREF(__pyx_r);
-  __Pyx_INCREF(((PyObject *)__pyx_v_result));
-  __pyx_r = ((PyObject *)__pyx_v_result);
-  goto __pyx_L0;
-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
-  goto __pyx_L0;
-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_2);
-  __Pyx_XDECREF(__pyx_t_6);
-  __Pyx_AddTraceback("csamtools.AlignedRead.tags.__get__");
-  __pyx_r = NULL;
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-  __Pyx_DECREF(__pyx_v_result);
-  __Pyx_DECREF(__pyx_v_value);
-  __Pyx_XGIVEREF(__pyx_r);
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-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2253
- *             return result
- * 
- *         def __set__(self, tags):             # <<<<<<<<<<<<<<
- *             cdef char * ctag
- *             cdef bam1_t * src
- */
-
-static int __pyx_pf_9csamtools_11AlignedRead_4tags___set__(PyObject *__pyx_v_self, PyObject *__pyx_v_tags); /*proto*/
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-  bam1_t *__pyx_v_src;
-  uint8_t *__pyx_v_s;
-  char *__pyx_v_temp;
-  int __pyx_v_max_size;
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- *             cigar_p = bam1_cigar(src)             # <<<<<<<<<<<<<<
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- *             cigar_p = bam1_cigar(src)
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- *                 op = cigar_p[k] & BAM_CIGAR_MASK             # <<<<<<<<<<<<<<
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- *             return result             # <<<<<<<<<<<<<<
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- *         cdef bam1_t * src
- * 
- *         overlap = 0             # <<<<<<<<<<<<<<
- * 
- *         src = self._delegate
- */
-  __pyx_v_overlap = 0;
-
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- *         overlap = 0
- * 
- *         src = self._delegate             # <<<<<<<<<<<<<<
- *         if src.core.n_cigar == 0: return 0
- *         pos = src.core.pos
- */
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-
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- * 
- *         src = self._delegate
- *         if src.core.n_cigar == 0: return 0             # <<<<<<<<<<<<<<
- *         pos = src.core.pos
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-    __Pyx_XDECREF(__pyx_r);
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- *         cigar_p = bam1_cigar(src)             # <<<<<<<<<<<<<<
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-
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- *         for k from 0 <= k < src.core.n_cigar:
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- *             if op == BAM_CMATCH:
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-    __pyx_t_3 = PyInt_FromLong(((__pyx_v_cigar_p[__pyx_v_k]) >> 4)); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2530; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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- *             if op == BAM_CMATCH:
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- * 
- *             if op == BAM_CMATCH or op == BAM_CDEL or op == BAM_CREF_SKIP:             # <<<<<<<<<<<<<<
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- * 
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- * 
- *             if op == BAM_CMATCH or op == BAM_CDEL or op == BAM_CREF_SKIP:
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- *                 pos += l
- * 
- *         return overlap             # <<<<<<<<<<<<<<
- * 
- *     def opt(self, tag):
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-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
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-  __Pyx_XDECREF(__pyx_t_3);
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- *         return overlap
- * 
- *     def opt(self, tag):             # <<<<<<<<<<<<<<
- *         """retrieves optional data given a two-letter *tag*"""
- *         #see bam_aux.c: bam_aux_get() and bam_aux2i() etc
- */
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-static PyObject *__pyx_pf_9csamtools_11AlignedRead_opt(PyObject *__pyx_v_self, PyObject *__pyx_v_tag); /*proto*/
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- *         #see bam_aux.c: bam_aux_get() and bam_aux2i() etc
- *         cdef uint8_t * v
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- *         if v == NULL: raise KeyError( "tag '%s' not present" % tag )
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- *         cdef uint8_t * v
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-    __Pyx_GOTREF(((PyObject *)__pyx_t_3));
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- *     cargs[0] = "samtools"
- *     cargs[1] = method             # <<<<<<<<<<<<<<
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-  (__pyx_v_cargs[1]) = __pyx_t_8;
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- *     for i from 0 <= i < n: cargs[i+2] = args[i]             # <<<<<<<<<<<<<<
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-    __Pyx_GOTREF(__pyx_t_4);
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- *     for i from 0 <= i < n: cargs[i+2] = args[i]
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-  free(__pyx_v_cargs);
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2800
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- *         stdout_save.restore()
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-  __pyx_t_3 = __Pyx_PyInt_AsInt(__pyx_t_2); if (unlikely((__pyx_t_3 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2902; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->errmod = __pyx_t_3;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2904
- *         self.c.errmod = kwargs.get( "errmod", BAM_ERRMOD_MAQ2 )
- * 
- *         self.c.min_baseQ = kwargs.get( "min_baseQ", 13 )             # <<<<<<<<<<<<<<
- *         # self.c.capQ_thres = kwargs.get( "capQ_threshold", 60 )
- *         self.c.n_hap = kwargs.get( "n_haplotypes", 2 )
- */
-  if (unlikely(__pyx_v_kwargs == Py_None)) {
-    PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'get'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2904; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
-  }
-  __pyx_t_2 = __Pyx_PyDict_GetItemDefault(((PyObject *)__pyx_v_kwargs), ((PyObject *)__pyx_n_s__min_baseQ), __pyx_int_13); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2904; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __pyx_t_3 = __Pyx_PyInt_AsInt(__pyx_t_2); if (unlikely((__pyx_t_3 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2904; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->min_baseQ = __pyx_t_3;
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2906
- *         self.c.min_baseQ = kwargs.get( "min_baseQ", 13 )
- *         # self.c.capQ_thres = kwargs.get( "capQ_threshold", 60 )
- *         self.c.n_hap = kwargs.get( "n_haplotypes", 2 )             # <<<<<<<<<<<<<<
- *         self.c.het_rate = kwargs.get( "het_rate", 0.001 )
- *         self.c.theta = kwargs.get( "theta", 0.83 )
- */
-  if (unlikely(__pyx_v_kwargs == Py_None)) {
-    PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'get'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2906; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
-  }
-  __pyx_t_2 = __Pyx_PyDict_GetItemDefault(((PyObject *)__pyx_v_kwargs), ((PyObject *)__pyx_n_s__n_haplotypes), __pyx_int_2); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2906; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __pyx_t_3 = __Pyx_PyInt_AsInt(__pyx_t_2); if (unlikely((__pyx_t_3 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2906; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->n_hap = __pyx_t_3;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2907
- *         # self.c.capQ_thres = kwargs.get( "capQ_threshold", 60 )
- *         self.c.n_hap = kwargs.get( "n_haplotypes", 2 )
- *         self.c.het_rate = kwargs.get( "het_rate", 0.001 )             # <<<<<<<<<<<<<<
- *         self.c.theta = kwargs.get( "theta", 0.83 )
- * 
- */
-  if (unlikely(__pyx_v_kwargs == Py_None)) {
-    PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'get'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2907; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
-  }
-  __pyx_t_2 = PyFloat_FromDouble(0.001); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2907; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __pyx_t_1 = __Pyx_PyDict_GetItemDefault(((PyObject *)__pyx_v_kwargs), ((PyObject *)__pyx_n_s__het_rate), __pyx_t_2); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2907; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-  ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->het_rate = __pyx_t_4;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2908
- *         self.c.n_hap = kwargs.get( "n_haplotypes", 2 )
- *         self.c.het_rate = kwargs.get( "het_rate", 0.001 )
- *         self.c.theta = kwargs.get( "theta", 0.83 )             # <<<<<<<<<<<<<<
- * 
- *         if self.c.errmod != BAM_ERRMOD_MAQ2:
- */
-  if (unlikely(__pyx_v_kwargs == Py_None)) {
-    PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'get'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2908; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
-  }
-  __pyx_t_1 = PyFloat_FromDouble(0.83); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2908; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __pyx_t_2 = __Pyx_PyDict_GetItemDefault(((PyObject *)__pyx_v_kwargs), ((PyObject *)__pyx_n_s__theta), __pyx_t_1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2908; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->theta = __pyx_t_4;
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-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2910
- *         self.c.theta = kwargs.get( "theta", 0.83 )
- * 
- *         if self.c.errmod != BAM_ERRMOD_MAQ2:             # <<<<<<<<<<<<<<
- *             self.c.theta += 0.02
- * 
- */
-  __pyx_t_5 = (((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->errmod != BAM_ERRMOD_MAQ2);
-  if (__pyx_t_5) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2911
- * 
- *         if self.c.errmod != BAM_ERRMOD_MAQ2:
- *             self.c.theta += 0.02             # <<<<<<<<<<<<<<
- * 
- *         # call prepare AFTER setting parameters
- */
-    ((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c->theta += 0.02;
-    goto __pyx_L6;
-  }
-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2914
- * 
- *         # call prepare AFTER setting parameters
- *         bam_maqcns_prepare( self.c )             # <<<<<<<<<<<<<<
- * 
- *     def __dealloc__(self):
- */
-  bam_maqcns_prepare(((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c);
-
-  __pyx_r = 0;
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-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_1);
-  __Pyx_XDECREF(__pyx_t_2);
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- * 
- *     def __dealloc__(self):             # <<<<<<<<<<<<<<
- *         bam_maqcns_destroy( self.c )
- * 
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-
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- * 
- *     def __dealloc__(self):
- *         bam_maqcns_destroy( self.c )             # <<<<<<<<<<<<<<
- * 
- *     cdef __dump( self, glf1_t * g, uint32_t cns, int rb ):
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-  bam_maqcns_destroy(((struct __pyx_obj_9csamtools_SNPCallerBase *)__pyx_v_self)->c);
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-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2919
- *         bam_maqcns_destroy( self.c )
- * 
- *     cdef __dump( self, glf1_t * g, uint32_t cns, int rb ):             # <<<<<<<<<<<<<<
- *         '''debugging output.'''
- * 
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- *         '''debugging output.'''
- * 
- *         pysam_dump_glf( g, self.c );             # <<<<<<<<<<<<<<
- *         print ""
- *         for x in range(self.iter.n_plp):
- */
-  pysam_dump_glf(__pyx_v_g, __pyx_v_self->c);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2923
- * 
- *         pysam_dump_glf( g, self.c );
- *         print ""             # <<<<<<<<<<<<<<
- *         for x in range(self.iter.n_plp):
- *             print "--> read %i %s %i" % (x,
- */
-  if (__Pyx_PrintOne(0, ((PyObject *)__pyx_kp_s_8)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2923; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2924
- *         pysam_dump_glf( g, self.c );
- *         print ""
- *         for x in range(self.iter.n_plp):             # <<<<<<<<<<<<<<
- *             print "--> read %i %s %i" % (x,
- *                                          bam1_qname(self.iter.plp[x].b),
- */
-  __pyx_t_1 = __pyx_v_self->iter->n_plp;
-  for (__pyx_t_2 = 0; __pyx_t_2 < __pyx_t_1; __pyx_t_2+=1) {
-    __pyx_v_x = __pyx_t_2;
-
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- *         print ""
- *         for x in range(self.iter.n_plp):
- *             print "--> read %i %s %i" % (x,             # <<<<<<<<<<<<<<
- *                                          bam1_qname(self.iter.plp[x].b),
- *                                          self.iter.plp[x].qpos,
- */
-    __pyx_t_3 = PyInt_FromLong(__pyx_v_x); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2925; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2926
- *         for x in range(self.iter.n_plp):
- *             print "--> read %i %s %i" % (x,
- *                                          bam1_qname(self.iter.plp[x].b),             # <<<<<<<<<<<<<<
- *                                          self.iter.plp[x].qpos,
- *                                          )
- */
-    __pyx_t_4 = PyBytes_FromString(bam1_qname((__pyx_v_self->iter->plp[__pyx_v_x]).b)); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2926; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_4));
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2927
- *             print "--> read %i %s %i" % (x,
- *                                          bam1_qname(self.iter.plp[x].b),
- *                                          self.iter.plp[x].qpos,             # <<<<<<<<<<<<<<
- *                                          )
- * 
- */
-    __pyx_t_5 = __Pyx_PyInt_to_py_int32_t((__pyx_v_self->iter->plp[__pyx_v_x]).qpos); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2927; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
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-    __Pyx_GOTREF(__pyx_t_6);
-    PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_3);
-    __Pyx_GIVEREF(__pyx_t_3);
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-    __Pyx_GIVEREF(((PyObject *)__pyx_t_4));
-    PyTuple_SET_ITEM(__pyx_t_6, 2, __pyx_t_5);
-    __Pyx_GIVEREF(__pyx_t_5);
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-    __Pyx_GOTREF(((PyObject *)__pyx_t_5));
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-    __Pyx_DECREF(((PyObject *)__pyx_t_5)); __pyx_t_5 = 0;
-  }
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2931
- * 
- *         print "pos=%i, cns=%i, q_r = %f, depth=%i, n=%i, rb=%i, cns-cq=%i %i %i %i" \
- *             % (self.iter.pos,             # <<<<<<<<<<<<<<
- *                cns,
- *                self.c.q_r,
- */
-  __pyx_t_5 = PyInt_FromLong(__pyx_v_self->iter->pos); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2931; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_5);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2932
- *         print "pos=%i, cns=%i, q_r = %f, depth=%i, n=%i, rb=%i, cns-cq=%i %i %i %i" \
- *             % (self.iter.pos,
- *                cns,             # <<<<<<<<<<<<<<
- *                self.c.q_r,
- *                self.iter.n_plp,
- */
-  __pyx_t_6 = __Pyx_PyInt_to_py_uint32_t(__pyx_v_cns); if (unlikely(!__pyx_t_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2932; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_6);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2933
- *             % (self.iter.pos,
- *                cns,
- *                self.c.q_r,             # <<<<<<<<<<<<<<
- *                self.iter.n_plp,
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- *         if self.iter.n_plp < 0:
- */
-  ((struct __pyx_vtabstruct_9csamtools_IteratorColumn *)((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->__pyx_vtab)->cnext(((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2976
- *         self.iter.cnext()
- * 
- *         if self.iter.n_plp < 0:             # <<<<<<<<<<<<<<
- *             raise ValueError("error during iteration" )
- * 
- */
-  __pyx_t_1 = (((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->n_plp < 0);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2977
- * 
- *         if self.iter.n_plp < 0:
- *             raise ValueError("error during iteration" )             # <<<<<<<<<<<<<<
- * 
- *         if self.iter.plp == NULL:
- */
-    __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2977; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_INCREF(((PyObject *)__pyx_kp_s_59));
-    PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_kp_s_59));
-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_59));
-    __pyx_t_3 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2977; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    __Pyx_Raise(__pyx_t_3, 0, 0);
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2977; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L5;
-  }
-  __pyx_L5:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2979
- *             raise ValueError("error during iteration" )
- * 
- *         if self.iter.plp == NULL:             # <<<<<<<<<<<<<<
- *            raise StopIteration
- * 
- */
-  __pyx_t_1 = (((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->plp == NULL);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2980
- * 
- *         if self.iter.plp == NULL:
- *            raise StopIteration             # <<<<<<<<<<<<<<
- * 
- *         cdef char * seq = self.iter.getSequence()
- */
-    __Pyx_Raise(__pyx_builtin_StopIteration, 0, 0);
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2980; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L6;
-  }
-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2982
- *            raise StopIteration
- * 
- *         cdef char * seq = self.iter.getSequence()             # <<<<<<<<<<<<<<
- *         cdef int seq_len = self.iter.seq_len
- * 
- */
-  __pyx_v_seq = ((struct __pyx_vtabstruct_9csamtools_IteratorColumn *)((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->__pyx_vtab)->getSequence(((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2983
- * 
- *         cdef char * seq = self.iter.getSequence()
- *         cdef int seq_len = self.iter.seq_len             # <<<<<<<<<<<<<<
- * 
- *         assert seq != NULL
- */
-  __pyx_t_3 = PyObject_GetAttr(((PyObject *)((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter), __pyx_n_s__seq_len); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2983; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __pyx_t_4 = __Pyx_PyInt_AsInt(__pyx_t_3); if (unlikely((__pyx_t_4 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2983; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  __pyx_v_seq_len = __pyx_t_4;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2985
- *         cdef int seq_len = self.iter.seq_len
- * 
- *         assert seq != NULL             # <<<<<<<<<<<<<<
- * 
- *         # reference base
- */
-  #ifndef PYREX_WITHOUT_ASSERTIONS
-  if (unlikely(!(__pyx_v_seq != NULL))) {
-    PyErr_SetNone(PyExc_AssertionError);
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2985; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  }
-  #endif
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2988
- * 
- *         # reference base
- *         if self.iter.pos >= seq_len:             # <<<<<<<<<<<<<<
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
- * 
- */
-  __pyx_t_1 = (((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->pos >= __pyx_v_seq_len);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2989
- *         # reference base
- *         if self.iter.pos >= seq_len:
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )             # <<<<<<<<<<<<<<
- * 
- *         cdef int rb = seq[self.iter.pos]
- */
-    __pyx_t_3 = PyInt_FromLong(((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->pos); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    __pyx_t_2 = PyInt_FromLong(__pyx_v_seq_len); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __pyx_t_5 = PyTuple_New(2); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_t_3);
-    __Pyx_GIVEREF(__pyx_t_3);
-    PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_2);
-    __Pyx_GIVEREF(__pyx_t_2);
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-    __pyx_t_2 = 0;
-    __pyx_t_2 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_108), __pyx_t_5); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_2));
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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-    __Pyx_GOTREF(__pyx_t_5);
-    PyTuple_SET_ITEM(__pyx_t_5, 0, ((PyObject *)__pyx_t_2));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_2));
-    __pyx_t_2 = 0;
-    __pyx_t_2 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_5, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_2);
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-    __Pyx_Raise(__pyx_t_2, 0, 0);
-    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2989; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L7;
-  }
-  __pyx_L7:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2991
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
- * 
- *         cdef int rb = seq[self.iter.pos]             # <<<<<<<<<<<<<<
- *         cdef uint32_t cns
- *         cdef glf1_t * g
- */
-  __pyx_v_rb = (__pyx_v_seq[((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->pos]);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2998
- *                                self.iter.plp,
- *                                bam_nt16_table[rb],
- *                                self.c )             # <<<<<<<<<<<<<<
- * 
- *         if pysam_glf_depth( g ) == 0:
- */
-  __pyx_v_g = bam_maqcns_glfgen(((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->n_plp, ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->plp, (bam_nt16_table[__pyx_v_rb]), ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.c);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3000
- *                                self.c )
- * 
- *         if pysam_glf_depth( g ) == 0:             # <<<<<<<<<<<<<<
- *             cns = 0xfu << 28 | 0xf << 24
- *         else:
- */
-  __pyx_t_1 = (pysam_glf_depth(__pyx_v_g) == 0);
-  if (__pyx_t_1) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3001
- * 
- *         if pysam_glf_depth( g ) == 0:
- *             cns = 0xfu << 28 | 0xf << 24             # <<<<<<<<<<<<<<
- *         else:
- *             cns = glf2cns(g, <int>(self.c.q_r + .499))
- */
-    __pyx_v_cns = 4278190080U;
-    goto __pyx_L8;
-  }
-  /*else*/ {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3003
- *             cns = 0xfu << 28 | 0xf << 24
- *         else:
- *             cns = glf2cns(g, <int>(self.c.q_r + .499))             # <<<<<<<<<<<<<<
- * 
- *         free(g)
- */
-    __pyx_v_cns = glf2cns(__pyx_v_g, ((int)(((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.c->q_r + .499)));
-  }
-  __pyx_L8:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3005
- *             cns = glf2cns(g, <int>(self.c.q_r + .499))
- * 
- *         free(g)             # <<<<<<<<<<<<<<
- * 
- *         cdef SNPCall call
- */
-  free(__pyx_v_g);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3009
- *         cdef SNPCall call
- * 
- *         call = SNPCall()             # <<<<<<<<<<<<<<
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos
- */
-  __pyx_t_2 = PyObject_Call(((PyObject *)((PyObject*)__pyx_ptype_9csamtools_SNPCall)), ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3009; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(((PyObject *)__pyx_v_call));
-  __pyx_v_call = ((struct __pyx_obj_9csamtools_SNPCall *)__pyx_t_2);
-  __pyx_t_2 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3010
- * 
- *         call = SNPCall()
- *         call._tid = self.iter.tid             # <<<<<<<<<<<<<<
- *         call._pos = self.iter.pos
- *         call._reference_base = rb
- */
-  __pyx_v_call->_tid = ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->tid;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3011
- *         call = SNPCall()
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos             # <<<<<<<<<<<<<<
- *         call._reference_base = rb
- *         call._genotype = bam_nt16_rev_table[cns>>28]
- */
-  __pyx_v_call->_pos = ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->pos;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3012
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos
- *         call._reference_base = rb             # <<<<<<<<<<<<<<
- *         call._genotype = bam_nt16_rev_table[cns>>28]
- *         call._consensus_quality = cns >> 8 & 0xff
- */
-  __pyx_v_call->_reference_base = __pyx_v_rb;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3013
- *         call._pos = self.iter.pos
- *         call._reference_base = rb
- *         call._genotype = bam_nt16_rev_table[cns>>28]             # <<<<<<<<<<<<<<
- *         call._consensus_quality = cns >> 8 & 0xff
- *         call._snp_quality = cns & 0xff
- */
-  __pyx_v_call->_genotype = (__pyx_v_9csamtools_bam_nt16_rev_table[(__pyx_v_cns >> 28)]);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3014
- *         call._reference_base = rb
- *         call._genotype = bam_nt16_rev_table[cns>>28]
- *         call._consensus_quality = cns >> 8 & 0xff             # <<<<<<<<<<<<<<
- *         call._snp_quality = cns & 0xff
- *         call._rms_mapping_quality = cns >> 16&0xff
- */
-  __pyx_v_call->_consensus_quality = ((__pyx_v_cns >> 8) & 0xff);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3015
- *         call._genotype = bam_nt16_rev_table[cns>>28]
- *         call._consensus_quality = cns >> 8 & 0xff
- *         call._snp_quality = cns & 0xff             # <<<<<<<<<<<<<<
- *         call._rms_mapping_quality = cns >> 16&0xff
- *         call._coverage = self.iter.n_plp
- */
-  __pyx_v_call->_snp_quality = (__pyx_v_cns & 0xff);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3016
- *         call._consensus_quality = cns >> 8 & 0xff
- *         call._snp_quality = cns & 0xff
- *         call._rms_mapping_quality = cns >> 16&0xff             # <<<<<<<<<<<<<<
- *         call._coverage = self.iter.n_plp
- * 
- */
-  __pyx_v_call->_rms_mapping_quality = ((__pyx_v_cns >> 16) & 0xff);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3017
- *         call._snp_quality = cns & 0xff
- *         call._rms_mapping_quality = cns >> 16&0xff
- *         call._coverage = self.iter.n_plp             # <<<<<<<<<<<<<<
- * 
- *         return call
- */
-  __pyx_v_call->_coverage = ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)__pyx_v_self)->__pyx_base.iter->n_plp;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3019
- *         call._coverage = self.iter.n_plp
- * 
- *         return call             # <<<<<<<<<<<<<<
- * 
- * cdef class SNPCaller( SNPCallerBase ):
- */
-  __Pyx_XDECREF(__pyx_r);
-  __Pyx_INCREF(((PyObject *)__pyx_v_call));
-  __pyx_r = ((PyObject *)__pyx_v_call);
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-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
-  goto __pyx_L0;
-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_2);
-  __Pyx_XDECREF(__pyx_t_3);
-  __Pyx_XDECREF(__pyx_t_5);
-  __Pyx_AddTraceback("csamtools.IteratorSNPCalls.__next__");
-  __pyx_r = NULL;
-  __pyx_L0:;
-  __Pyx_DECREF((PyObject *)__pyx_v_call);
-  __Pyx_XGIVEREF(__pyx_r);
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-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3035
- * 
- * 
- *     def __cinit__(self,             # <<<<<<<<<<<<<<
- *                   IteratorColumn iterator_column,
- *                   **kwargs ):
- */
-
-static int __pyx_pf_9csamtools_9SNPCaller___cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
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-  struct __pyx_obj_9csamtools_IteratorColumn *__pyx_v_iterator_column = 0;
-  PyObject *__pyx_v_kwargs = 0;
-  int __pyx_r;
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- *         cdef int seq_len = self.iter.seq_len
- * 
- *         assert seq != NULL             # <<<<<<<<<<<<<<
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- *         # reference base
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-  #ifndef PYREX_WITHOUT_ASSERTIONS
-  if (unlikely(!(__pyx_v_seq != NULL))) {
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3069
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- *         # reference base
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- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
- * 
- */
-  __pyx_t_6 = (((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.iter->pos >= __pyx_v_seq_len);
-  if (__pyx_t_6) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3070
- *         # reference base
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- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )             # <<<<<<<<<<<<<<
- * 
- *         cdef int rb = seq[self.iter.pos]
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-    __Pyx_GOTREF(__pyx_t_1);
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-  __pyx_L11:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3072
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
- * 
- *         cdef int rb = seq[self.iter.pos]             # <<<<<<<<<<<<<<
- *         cdef uint32_t cns
- *         cdef glf1_t * g
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-  __pyx_v_rb = (__pyx_v_seq[((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.iter->pos]);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3079
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- *                                bam_nt16_table[rb],
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- * 
- * 
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-  __pyx_v_g = bam_maqcns_glfgen(((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.iter->n_plp, ((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.iter->plp, (bam_nt16_table[__pyx_v_rb]), ((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.c);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3082
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- * 
- *         if pysam_glf_depth( g ) == 0:             # <<<<<<<<<<<<<<
- *             cns = 0xfu << 28 | 0xf << 24
- *         else:
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-
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- * 
- *         if pysam_glf_depth( g ) == 0:
- *             cns = 0xfu << 28 | 0xf << 24             # <<<<<<<<<<<<<<
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-    goto __pyx_L12;
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-  /*else*/ {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3085
- *             cns = 0xfu << 28 | 0xf << 24
- *         else:
- *             cns = glf2cns(g, <int>(self.c.q_r + .499))             # <<<<<<<<<<<<<<
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- *         free(g)
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-  }
-  __pyx_L12:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3087
- *             cns = glf2cns(g, <int>(self.c.q_r + .499))
- * 
- *         free(g)             # <<<<<<<<<<<<<<
- * 
- *         cdef SNPCall call
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3091
- *         cdef SNPCall call
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- *         call = SNPCall()             # <<<<<<<<<<<<<<
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos
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-  __pyx_t_1 = PyObject_Call(((PyObject *)((PyObject*)__pyx_ptype_9csamtools_SNPCall)), ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3091; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __Pyx_DECREF(((PyObject *)__pyx_v_call));
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3092
- * 
- *         call = SNPCall()
- *         call._tid = self.iter.tid             # <<<<<<<<<<<<<<
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-  __pyx_v_call->_tid = ((struct __pyx_obj_9csamtools_SNPCaller *)__pyx_v_self)->__pyx_base.iter->tid;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3093
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- *         call._pos = self.iter.pos             # <<<<<<<<<<<<<<
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- *         call._pos = self.iter.pos
- *         call._reference_base = rb             # <<<<<<<<<<<<<<
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3095
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- *         call._reference_base = rb
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-  int __pyx_v_seq_len;
-  bam_maqindel_ret_t *__pyx_v_r;
-  int __pyx_v_m;
-  struct __pyx_obj_9csamtools_IndelCall *__pyx_v_call;
-  uint64_t __pyx_v_rms_aux;
-  int __pyx_v_i;
-  bam_pileup1_t *__pyx_v_p;
-  int __pyx_v_tmp;
-  PyObject *__pyx_r = NULL;
-  PyObject *__pyx_t_1 = NULL;
-  int __pyx_t_2;
-  int __pyx_t_3;
-  PyObject *__pyx_t_4 = NULL;
-  PyObject *__pyx_t_5 = NULL;
-  int __pyx_t_6;
-  int __pyx_t_7;
-  double __pyx_t_8;
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("_call");
-  __Pyx_TraceCall("_call", __pyx_f[0], 3234);
-  __pyx_v_call = ((struct __pyx_obj_9csamtools_IndelCall *)Py_None); __Pyx_INCREF(Py_None);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3236
- *     def _call( self ):
- * 
- *         cdef char * seq = self.iter.getSequence()             # <<<<<<<<<<<<<<
- *         cdef int seq_len = self.iter.seq_len
- * 
- */
-  __pyx_v_seq = ((struct __pyx_vtabstruct_9csamtools_IteratorColumn *)((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->__pyx_vtab)->getSequence(((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3237
- * 
- *         cdef char * seq = self.iter.getSequence()
- *         cdef int seq_len = self.iter.seq_len             # <<<<<<<<<<<<<<
- * 
- *         assert seq != NULL
- */
-  __pyx_t_1 = PyObject_GetAttr(((PyObject *)((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter), __pyx_n_s__seq_len); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_1);
-  __pyx_t_2 = __Pyx_PyInt_AsInt(__pyx_t_1); if (unlikely((__pyx_t_2 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3237; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
-  __pyx_v_seq_len = __pyx_t_2;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3239
- *         cdef int seq_len = self.iter.seq_len
- * 
- *         assert seq != NULL             # <<<<<<<<<<<<<<
- * 
- *         # reference base
- */
-  #ifndef PYREX_WITHOUT_ASSERTIONS
-  if (unlikely(!(__pyx_v_seq != NULL))) {
-    PyErr_SetNone(PyExc_AssertionError);
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3239; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  }
-  #endif
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3242
- * 
- *         # reference base
- *         if self.iter.pos >= seq_len:             # <<<<<<<<<<<<<<
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
- * 
- */
-  __pyx_t_3 = (((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->pos >= __pyx_v_seq_len);
-  if (__pyx_t_3) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3243
- *         # reference base
- *         if self.iter.pos >= seq_len:
- *             raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )             # <<<<<<<<<<<<<<
- * 
- *         cdef bam_maqindel_ret_t * r
- */
-    __pyx_t_1 = PyInt_FromLong(((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->pos); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_1);
-    __pyx_t_4 = PyInt_FromLong(__pyx_v_seq_len); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_4);
-    __pyx_t_5 = PyTuple_New(2); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_t_1);
-    __Pyx_GIVEREF(__pyx_t_1);
-    PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_4);
-    __Pyx_GIVEREF(__pyx_t_4);
-    __pyx_t_1 = 0;
-    __pyx_t_4 = 0;
-    __pyx_t_4 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_108), __pyx_t_5); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_4));
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-    __pyx_t_5 = PyTuple_New(1); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    PyTuple_SET_ITEM(__pyx_t_5, 0, ((PyObject *)__pyx_t_4));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_4));
-    __pyx_t_4 = 0;
-    __pyx_t_4 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_5, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_4);
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-    __Pyx_Raise(__pyx_t_4, 0, 0);
-    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3243; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L5;
-  }
-  __pyx_L5:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3247
- *         cdef bam_maqindel_ret_t * r
- * 
- *         cdef int m = min( self.max_depth, self.iter.n_plp )             # <<<<<<<<<<<<<<
- * 
- *         # printf("pysam: m=%i, q_indel=%i, r_indel=%f, r_snp=%i, mm_penalty=%i, indel_err=%i, ambi_thres=%i\n",
- */
-  __pyx_t_2 = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->n_plp;
-  __pyx_t_6 = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->max_depth;
-  if ((__pyx_t_2 < __pyx_t_6)) {
-    __pyx_t_7 = __pyx_t_2;
-  } else {
-    __pyx_t_7 = __pyx_t_6;
-  }
-  __pyx_v_m = __pyx_t_7;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3259
- *                          seq,
- *                          0,
- *                          NULL)             # <<<<<<<<<<<<<<
- * 
- *         if r == NULL: return None
- */
-  __pyx_v_r = bam_maqindel(__pyx_v_m, ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->pos, ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->options, ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->plp, __pyx_v_seq, 0, NULL);
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3261
- *                          NULL)
- * 
- *         if r == NULL: return None             # <<<<<<<<<<<<<<
- * 
- *         cdef IndelCall call
- */
-  __pyx_t_3 = (__pyx_v_r == NULL);
-  if (__pyx_t_3) {
-    __Pyx_XDECREF(__pyx_r);
-    __Pyx_INCREF(Py_None);
-    __pyx_r = Py_None;
-    goto __pyx_L0;
-    goto __pyx_L6;
-  }
-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3264
- * 
- *         cdef IndelCall call
- *         call = IndelCall()             # <<<<<<<<<<<<<<
- *         call._r = r
- *         call._tid = self.iter.tid
- */
-  __pyx_t_4 = PyObject_Call(((PyObject *)((PyObject*)__pyx_ptype_9csamtools_IndelCall)), ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3264; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_4);
-  __Pyx_DECREF(((PyObject *)__pyx_v_call));
-  __pyx_v_call = ((struct __pyx_obj_9csamtools_IndelCall *)__pyx_t_4);
-  __pyx_t_4 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3265
- *         cdef IndelCall call
- *         call = IndelCall()
- *         call._r = r             # <<<<<<<<<<<<<<
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos
- */
-  __pyx_v_call->_r = __pyx_v_r;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3266
- *         call = IndelCall()
- *         call._r = r
- *         call._tid = self.iter.tid             # <<<<<<<<<<<<<<
- *         call._pos = self.iter.pos
- *         call._coverage = self.iter.n_plp
- */
-  __pyx_v_call->_tid = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->tid;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3267
- *         call._r = r
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos             # <<<<<<<<<<<<<<
- *         call._coverage = self.iter.n_plp
- * 
- */
-  __pyx_v_call->_pos = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->pos;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3268
- *         call._tid = self.iter.tid
- *         call._pos = self.iter.pos
- *         call._coverage = self.iter.n_plp             # <<<<<<<<<<<<<<
- * 
- *         cdef uint64_t rms_aux = 0
- */
-  __pyx_v_call->_coverage = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->n_plp;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3270
- *         call._coverage = self.iter.n_plp
- * 
- *         cdef uint64_t rms_aux = 0             # <<<<<<<<<<<<<<
- *         cdef int i = 0
- *         cdef bam_pileup1_t * p
- */
-  __pyx_v_rms_aux = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3271
- * 
- *         cdef uint64_t rms_aux = 0
- *         cdef int i = 0             # <<<<<<<<<<<<<<
- *         cdef bam_pileup1_t * p
- *         cdef int tmp
- */
-  __pyx_v_i = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3275
- *         cdef int tmp
- * 
- *         for i from 0 <= i < self.iter.n_plp:             # <<<<<<<<<<<<<<
- *             p = self.iter.plp + i
- *             if p.b.core.qual < self.cap_mapQ:
- */
-  __pyx_t_7 = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->n_plp;
-  for (__pyx_v_i = 0; __pyx_v_i < __pyx_t_7; __pyx_v_i++) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3276
- * 
- *         for i from 0 <= i < self.iter.n_plp:
- *             p = self.iter.plp + i             # <<<<<<<<<<<<<<
- *             if p.b.core.qual < self.cap_mapQ:
- *                 tmp = p.b.core.qual
- */
-    __pyx_v_p = (((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->plp + __pyx_v_i);
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3277
- *         for i from 0 <= i < self.iter.n_plp:
- *             p = self.iter.plp + i
- *             if p.b.core.qual < self.cap_mapQ:             # <<<<<<<<<<<<<<
- *                 tmp = p.b.core.qual
- *             else:
- */
-    __pyx_t_3 = (__pyx_v_p->b->core.qual < ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->cap_mapQ);
-    if (__pyx_t_3) {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3278
- *             p = self.iter.plp + i
- *             if p.b.core.qual < self.cap_mapQ:
- *                 tmp = p.b.core.qual             # <<<<<<<<<<<<<<
- *             else:
- *                 tmp = self.cap_mapQ
- */
-      __pyx_v_tmp = __pyx_v_p->b->core.qual;
-      goto __pyx_L9;
-    }
-    /*else*/ {
-
-      /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3280
- *                 tmp = p.b.core.qual
- *             else:
- *                 tmp = self.cap_mapQ             # <<<<<<<<<<<<<<
- *             rms_aux += tmp * tmp
- * 
- */
-      __pyx_v_tmp = ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->cap_mapQ;
-    }
-    __pyx_L9:;
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3281
- *             else:
- *                 tmp = self.cap_mapQ
- *             rms_aux += tmp * tmp             # <<<<<<<<<<<<<<
- * 
- *         call._rms_mapping_quality = <uint64_t>(sqrt(<double>rms_aux / self.iter.n_plp) + .499)
- */
-    __pyx_v_rms_aux += (__pyx_v_tmp * __pyx_v_tmp);
-  }
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3283
- *             rms_aux += tmp * tmp
- * 
- *         call._rms_mapping_quality = <uint64_t>(sqrt(<double>rms_aux / self.iter.n_plp) + .499)             # <<<<<<<<<<<<<<
- * 
- *         return call
- */
-  __pyx_t_8 = ((double)__pyx_v_rms_aux);
-  if (unlikely(((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->n_plp == 0)) {
-    PyErr_Format(PyExc_ZeroDivisionError, "float division");
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3283; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  }
-  __pyx_v_call->_rms_mapping_quality = ((uint64_t)(sqrt((__pyx_t_8 / ((struct __pyx_obj_9csamtools_IndelCallerBase *)__pyx_v_self)->iter->n_plp)) + .499));
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3285
- *         call._rms_mapping_quality = <uint64_t>(sqrt(<double>rms_aux / self.iter.n_plp) + .499)
- * 
- *         return call             # <<<<<<<<<<<<<<
- * 
- * cdef class IndelCaller( IndelCallerBase ):
- */
-  __Pyx_XDECREF(__pyx_r);
-  __Pyx_INCREF(((PyObject *)__pyx_v_call));
-  __pyx_r = ((PyObject *)__pyx_v_call);
-  goto __pyx_L0;
-
-  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
-  goto __pyx_L0;
-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_1);
-  __Pyx_XDECREF(__pyx_t_4);
-  __Pyx_XDECREF(__pyx_t_5);
-  __Pyx_AddTraceback("csamtools.IndelCallerBase._call");
-  __pyx_r = NULL;
-  __pyx_L0:;
-  __Pyx_DECREF((PyObject *)__pyx_v_call);
-  __Pyx_XGIVEREF(__pyx_r);
-  __Pyx_TraceReturn(__pyx_r);
-  __Pyx_RefNannyFinishContext();
-  return __pyx_r;
-}
-
-/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3300
- *     '''
- * 
- *     def __cinit__(self,             # <<<<<<<<<<<<<<
- *                   IteratorColumn iterator_column,
- *                   **kwargs ):
- */
-
-static int __pyx_pf_9csamtools_11IndelCaller___cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
-static int __pyx_pf_9csamtools_11IndelCaller___cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
-  struct __pyx_obj_9csamtools_IteratorColumn *__pyx_v_iterator_column = 0;
-  PyObject *__pyx_v_kwargs = 0;
-  int __pyx_r;
-  static PyObject **__pyx_pyargnames[] = {&__pyx_n_s__iterator_column,0};
-  __Pyx_TraceDeclarations
-  __Pyx_RefNannySetupContext("__cinit__");
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-  __Pyx_GOTREF(__pyx_v_kwargs);
-  if (unlikely(__pyx_kwds)) {
-    Py_ssize_t kw_args = PyDict_Size(__pyx_kwds);
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-    switch (PyTuple_GET_SIZE(__pyx_args)) {
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- *     def __dealloc__(self):             # <<<<<<<<<<<<<<
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_qend(PyObject *o, void *x) {
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-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_qlen(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4qlen___get__(o);
-}
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_tags(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4tags___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_tags(PyObject *o, PyObject *v, void *x) {
-  if (v) {
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-  }
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-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_flag(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4flag___get__(o);
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-
-static int __pyx_setprop_9csamtools_11AlignedRead_flag(PyObject *o, PyObject *v, void *x) {
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-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_rname(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_5rname___get__(o);
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-static int __pyx_setprop_9csamtools_11AlignedRead_rname(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_5rname___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_tid(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_3tid___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_tid(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_3tid___set__(o, v);
-  }
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-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
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-  }
-}
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_pos(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_3pos___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_pos(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_3pos___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
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-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_bin(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_3bin___get__(o);
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-
-static int __pyx_setprop_9csamtools_11AlignedRead_bin(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_3bin___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
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-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_rlen(PyObject *o, void *x) {
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_aend(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4aend___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_alen(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4alen___get__(o);
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_mapq(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_4mapq___get__(o);
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-static int __pyx_setprop_9csamtools_11AlignedRead_mapq(PyObject *o, PyObject *v, void *x) {
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-  }
-  else {
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-    return -1;
-  }
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_mrnm(PyObject *o, void *x) {
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-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_proper_pair(PyObject *o, void *x) {
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-static int __pyx_setprop_9csamtools_11AlignedRead_is_proper_pair(PyObject *o, PyObject *v, void *x) {
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-}
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-static int __pyx_setprop_9csamtools_11AlignedRead_is_read2(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_8is_read2___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_secondary(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_12is_secondary___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_is_secondary(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_12is_secondary___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_qcfail(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_9is_qcfail___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_is_qcfail(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_9is_qcfail___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_duplicate(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_12is_duplicate___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11AlignedRead_is_duplicate(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11AlignedRead_12is_duplicate___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11AlignedRead_positions(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11AlignedRead_9positions___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_AlignedRead[] = {
-  {__Pyx_NAMESTR("compare"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_compare, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_compare)},
-  {__Pyx_NAMESTR("overlap"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_overlap, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_overlap)},
-  {__Pyx_NAMESTR("opt"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_opt, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_opt)},
-  {__Pyx_NAMESTR("fancy_str"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_fancy_str, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_fancy_str)},
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_AlignedRead[] = {
-  {(char *)"qname", __pyx_getprop_9csamtools_11AlignedRead_qname, __pyx_setprop_9csamtools_11AlignedRead_qname, __Pyx_DOCSTR(__pyx_k_114), 0},
-  {(char *)"cigar", __pyx_getprop_9csamtools_11AlignedRead_cigar, __pyx_setprop_9csamtools_11AlignedRead_cigar, __Pyx_DOCSTR(__pyx_k_115), 0},
-  {(char *)"seq", __pyx_getprop_9csamtools_11AlignedRead_seq, __pyx_setprop_9csamtools_11AlignedRead_seq, __Pyx_DOCSTR(__pyx_k_116), 0},
-  {(char *)"qual", __pyx_getprop_9csamtools_11AlignedRead_qual, __pyx_setprop_9csamtools_11AlignedRead_qual, __Pyx_DOCSTR(__pyx_k_117), 0},
-  {(char *)"query", __pyx_getprop_9csamtools_11AlignedRead_query, 0, __Pyx_DOCSTR(__pyx_k_118), 0},
-  {(char *)"qqual", __pyx_getprop_9csamtools_11AlignedRead_qqual, 0, __Pyx_DOCSTR(__pyx_k_119), 0},
-  {(char *)"qstart", __pyx_getprop_9csamtools_11AlignedRead_qstart, 0, __Pyx_DOCSTR(__pyx_k_120), 0},
-  {(char *)"qend", __pyx_getprop_9csamtools_11AlignedRead_qend, 0, __Pyx_DOCSTR(__pyx_k_121), 0},
-  {(char *)"qlen", __pyx_getprop_9csamtools_11AlignedRead_qlen, 0, __Pyx_DOCSTR(__pyx_k_122), 0},
-  {(char *)"tags", __pyx_getprop_9csamtools_11AlignedRead_tags, __pyx_setprop_9csamtools_11AlignedRead_tags, __Pyx_DOCSTR(__pyx_k_123), 0},
-  {(char *)"flag", __pyx_getprop_9csamtools_11AlignedRead_flag, __pyx_setprop_9csamtools_11AlignedRead_flag, __Pyx_DOCSTR(__pyx_k_124), 0},
-  {(char *)"rname", __pyx_getprop_9csamtools_11AlignedRead_rname, __pyx_setprop_9csamtools_11AlignedRead_rname, __Pyx_DOCSTR(__pyx_k_125), 0},
-  {(char *)"tid", __pyx_getprop_9csamtools_11AlignedRead_tid, __pyx_setprop_9csamtools_11AlignedRead_tid, __Pyx_DOCSTR(__pyx_k_126), 0},
-  {(char *)"pos", __pyx_getprop_9csamtools_11AlignedRead_pos, __pyx_setprop_9csamtools_11AlignedRead_pos, __Pyx_DOCSTR(__pyx_k_127), 0},
-  {(char *)"bin", __pyx_getprop_9csamtools_11AlignedRead_bin, __pyx_setprop_9csamtools_11AlignedRead_bin, __Pyx_DOCSTR(__pyx_k_128), 0},
-  {(char *)"rlen", __pyx_getprop_9csamtools_11AlignedRead_rlen, 0, __Pyx_DOCSTR(__pyx_k_129), 0},
-  {(char *)"aend", __pyx_getprop_9csamtools_11AlignedRead_aend, 0, __Pyx_DOCSTR(__pyx_k_130), 0},
-  {(char *)"alen", __pyx_getprop_9csamtools_11AlignedRead_alen, 0, __Pyx_DOCSTR(__pyx_k_131), 0},
-  {(char *)"mapq", __pyx_getprop_9csamtools_11AlignedRead_mapq, __pyx_setprop_9csamtools_11AlignedRead_mapq, __Pyx_DOCSTR(__pyx_k_132), 0},
-  {(char *)"mrnm", __pyx_getprop_9csamtools_11AlignedRead_mrnm, __pyx_setprop_9csamtools_11AlignedRead_mrnm, __Pyx_DOCSTR(__pyx_k_133), 0},
-  {(char *)"mpos", __pyx_getprop_9csamtools_11AlignedRead_mpos, __pyx_setprop_9csamtools_11AlignedRead_mpos, __Pyx_DOCSTR(__pyx_k_134), 0},
-  {(char *)"isize", __pyx_getprop_9csamtools_11AlignedRead_isize, __pyx_setprop_9csamtools_11AlignedRead_isize, __Pyx_DOCSTR(__pyx_k_135), 0},
-  {(char *)"is_paired", __pyx_getprop_9csamtools_11AlignedRead_is_paired, __pyx_setprop_9csamtools_11AlignedRead_is_paired, __Pyx_DOCSTR(__pyx_k_136), 0},
-  {(char *)"is_proper_pair", __pyx_getprop_9csamtools_11AlignedRead_is_proper_pair, __pyx_setprop_9csamtools_11AlignedRead_is_proper_pair, __Pyx_DOCSTR(__pyx_k_137), 0},
-  {(char *)"is_unmapped", __pyx_getprop_9csamtools_11AlignedRead_is_unmapped, __pyx_setprop_9csamtools_11AlignedRead_is_unmapped, __Pyx_DOCSTR(__pyx_k_138), 0},
-  {(char *)"mate_is_unmapped", __pyx_getprop_9csamtools_11AlignedRead_mate_is_unmapped, __pyx_setprop_9csamtools_11AlignedRead_mate_is_unmapped, __Pyx_DOCSTR(__pyx_k_139), 0},
-  {(char *)"is_reverse", __pyx_getprop_9csamtools_11AlignedRead_is_reverse, __pyx_setprop_9csamtools_11AlignedRead_is_reverse, __Pyx_DOCSTR(__pyx_k_140), 0},
-  {(char *)"mate_is_reverse", __pyx_getprop_9csamtools_11AlignedRead_mate_is_reverse, __pyx_setprop_9csamtools_11AlignedRead_mate_is_reverse, __Pyx_DOCSTR(__pyx_k_141), 0},
-  {(char *)"is_read1", __pyx_getprop_9csamtools_11AlignedRead_is_read1, __pyx_setprop_9csamtools_11AlignedRead_is_read1, __Pyx_DOCSTR(__pyx_k_142), 0},
-  {(char *)"is_read2", __pyx_getprop_9csamtools_11AlignedRead_is_read2, __pyx_setprop_9csamtools_11AlignedRead_is_read2, __Pyx_DOCSTR(__pyx_k_143), 0},
-  {(char *)"is_secondary", __pyx_getprop_9csamtools_11AlignedRead_is_secondary, __pyx_setprop_9csamtools_11AlignedRead_is_secondary, __Pyx_DOCSTR(__pyx_k_144), 0},
-  {(char *)"is_qcfail", __pyx_getprop_9csamtools_11AlignedRead_is_qcfail, __pyx_setprop_9csamtools_11AlignedRead_is_qcfail, __Pyx_DOCSTR(__pyx_k_145), 0},
-  {(char *)"is_duplicate", __pyx_getprop_9csamtools_11AlignedRead_is_duplicate, __pyx_setprop_9csamtools_11AlignedRead_is_duplicate, __Pyx_DOCSTR(__pyx_k_146), 0},
-  {(char *)"positions", __pyx_getprop_9csamtools_11AlignedRead_positions, 0, __Pyx_DOCSTR(__pyx_k_147), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_AlignedRead = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_AlignedRead = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_AlignedRead = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_AlignedRead = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_AlignedRead = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.AlignedRead"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_AlignedRead), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_AlignedRead, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_AlignedRead, /*tp_as_number*/
-  &__pyx_tp_as_sequence_AlignedRead, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_AlignedRead, /*tp_as_mapping*/
-  __pyx_pf_9csamtools_11AlignedRead___hash__, /*tp_hash*/
-  0, /*tp_call*/
-  __pyx_pf_9csamtools_11AlignedRead___str__, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_AlignedRead, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("AlignedRead()\n\n    Class representing an aligned read. see SAM format specification for \n    the meaning of fields (http://samtools.sourceforge.net/).\n\n    This class stores a handle to the samtools C-structure representing\n    an aligned read. Member read access is forwarded to the C-structure\n    and converted into python objects. This implementation should be fast,\n    as only the data needed is converted.\n\n    For write access, the C-structure is updated in-place. This is\n    not the most efficient way to build BAM entries, as the variable\n    length data is concatenated and thus needs to resized if\n    a field is updated. Furthermore, the BAM entry might be\n    in an inconsistent state. The :meth:`~validate` method can\n    be used to check if an entry is consistent.\n\n    One issue to look out for is that the sequence should always\n    be set *before* the quality scores. Setting the sequence will\n    also erase any quality scores that were set previously.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_AlignedRead, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_AlignedRead, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  __pyx_pf_9csamtools_11AlignedRead___init__, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_AlignedRead, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_Samfile __pyx_vtable_9csamtools_Samfile;
-
-static PyObject *__pyx_tp_new_9csamtools_Samfile(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_Samfile *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_Samfile *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_Samfile;
-  if (__pyx_pf_9csamtools_7Samfile___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_Samfile(PyObject *o) {
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_7Samfile___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_filename(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_8filename___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_nreferences(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_11nreferences___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_references(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_10references___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_lengths(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_7lengths___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_text(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_4text___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7Samfile_header(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7Samfile_6header___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_Samfile[] = {
-  {__Pyx_NAMESTR("_isOpen"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__isOpen, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__isOpen)},
-  {__Pyx_NAMESTR("_hasIndex"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__hasIndex, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__hasIndex)},
-  {__Pyx_NAMESTR("_open"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__open, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__open)},
-  {__Pyx_NAMESTR("gettid"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_gettid, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_gettid)},
-  {__Pyx_NAMESTR("getrname"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_getrname, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_getrname)},
-  {__Pyx_NAMESTR("_parseRegion"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__parseRegion, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__parseRegion)},
-  {__Pyx_NAMESTR("seek"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_seek, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_seek)},
-  {__Pyx_NAMESTR("tell"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_tell, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_tell)},
-  {__Pyx_NAMESTR("fetch"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_fetch, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_fetch)},
-  {__Pyx_NAMESTR("mate"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_mate, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_mate)},
-  {__Pyx_NAMESTR("count"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_count, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_count)},
-  {__Pyx_NAMESTR("pileup"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_pileup, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_pileup)},
-  {__Pyx_NAMESTR("close"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_close, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_close)},
-  {__Pyx_NAMESTR("write"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_write, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_write)},
-  {__Pyx_NAMESTR("__enter__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___enter__, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___enter__)},
-  {__Pyx_NAMESTR("__exit__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___exit__, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___exit__)},
-  {__Pyx_NAMESTR("_buildLine"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__buildLine, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__buildLine)},
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___next__)},
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_Samfile[] = {
-  {(char *)"filename", __pyx_getprop_9csamtools_7Samfile_filename, 0, __Pyx_DOCSTR(__pyx_k_148), 0},
-  {(char *)"nreferences", __pyx_getprop_9csamtools_7Samfile_nreferences, 0, __Pyx_DOCSTR(__pyx_k_149), 0},
-  {(char *)"references", __pyx_getprop_9csamtools_7Samfile_references, 0, __Pyx_DOCSTR(__pyx_k_150), 0},
-  {(char *)"lengths", __pyx_getprop_9csamtools_7Samfile_lengths, 0, __Pyx_DOCSTR(__pyx_k_151), 0},
-  {(char *)"text", __pyx_getprop_9csamtools_7Samfile_text, 0, __Pyx_DOCSTR(__pyx_k_152), 0},
-  {(char *)"header", __pyx_getprop_9csamtools_7Samfile_header, 0, __Pyx_DOCSTR(__pyx_k_153), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_Samfile = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_Samfile = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_Samfile = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_Samfile = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_Samfile = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.Samfile"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_Samfile), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_Samfile, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_Samfile, /*tp_as_number*/
-  &__pyx_tp_as_sequence_Samfile, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_Samfile, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_Samfile, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("*(filename, mode=None, template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*\n              \n    A :term:`SAM`/:term:`BAM` formatted file. The file is automatically opened.\n    \n    *mode* should be ``r`` for reading or ``w`` for writing. The default is text mode (:term:`SAM`). For binary \n    (:term:`BAM`) I/O you should append ``b`` for compressed or ``u`` for uncompressed :term:`BAM` output. \n    Use ``h`` to output header information in text (:term:`TAM`)  mode.\n\n    If ``b`` is present, it must immediately follow ``r`` or ``w``. \n    Valid modes are ``r``, ``w``, ``wh``, ``rb``, ``wb`` and ``wbu``. For instance, to open \n    a :term:`BAM` formatted file for reading, type::\n\n        f = pysam.Samfile('ex1.bam','rb')\n\n    If mode is not specified, we will try to auto-detect in the order 'r', 'rb', thus both the following\n    should work::\n\n        f1 = pysam.Samfile('ex1.bam' )\n        f2 = pysam.Samfile('ex1.bam' )\n\n    If an index for a BAM file exists (.bai), it will be opened automatically. Without an index random\n    access to reads via :meth:`fetch` and :meth:`pileup` is disabled.\n\n    For writing, the header of a :term:`SAM` file/:term:`BAM` file can be constituted from several\n    sources (see also the samtools format specification):\n\n        1. If *template* is given, the header is copied from a another *Samfile* \n           (*template* must be of type *Samfile*).\n\n        2. If *header* is given, the header is built from a multi-level dictionary. The first level \n           are the four types ('HD', 'SQ', ...). The second level are a list of lines, with each line \n           being a list of tag-value pairs.\n\n        3. If *text* is given, new header text is copied from raw text.\n\n        4. The names (*referencenames*) and lengths (*referencelengths*) are supplied directly as lists. \n\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_7Samfile___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_7Samfile___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_Samfile, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_Samfile, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_Samfile, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_PileupProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_PileupProxy(PyObject *o) {
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_11PileupProxy_tid(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11PileupProxy_3tid___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_11PileupProxy_n(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11PileupProxy_1n___get__(o);
-}
-
-static int __pyx_setprop_9csamtools_11PileupProxy_n(PyObject *o, PyObject *v, void *x) {
-  if (v) {
-    return __pyx_pf_9csamtools_11PileupProxy_1n___set__(o, v);
-  }
-  else {
-    PyErr_SetString(PyExc_NotImplementedError, "__del__");
-    return -1;
-  }
-}
-
-static PyObject *__pyx_getprop_9csamtools_11PileupProxy_pos(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11PileupProxy_3pos___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_11PileupProxy_pileups(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_11PileupProxy_7pileups___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_PileupProxy[] = {
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_PileupProxy[] = {
-  {(char *)"tid", __pyx_getprop_9csamtools_11PileupProxy_tid, 0, __Pyx_DOCSTR(__pyx_k_154), 0},
-  {(char *)"n", __pyx_getprop_9csamtools_11PileupProxy_n, __pyx_setprop_9csamtools_11PileupProxy_n, __Pyx_DOCSTR(__pyx_k_155), 0},
-  {(char *)"pos", __pyx_getprop_9csamtools_11PileupProxy_pos, 0, 0, 0},
-  {(char *)"pileups", __pyx_getprop_9csamtools_11PileupProxy_pileups, 0, __Pyx_DOCSTR(__pyx_k_156), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_PileupProxy = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_PileupProxy = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_PileupProxy = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_PileupProxy = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_PileupProxy = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.PileupProxy"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_PileupProxy), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_PileupProxy, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_PileupProxy, /*tp_as_number*/
-  &__pyx_tp_as_sequence_PileupProxy, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_PileupProxy, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  __pyx_pf_9csamtools_11PileupProxy___str__, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_PileupProxy, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("PileupProxy()\nA pileup column. A pileup column contains\n    all the reads that map to a certain target base.\n\n    tid\n        chromosome ID as is defined in the header\n    pos\n        the target base coordinate (0-based)\n    n\n        number of reads mapping to this column    \n    pileups\n        list of reads (:class:`pysam.PileupRead`) aligned to this column\n\n    This class is a proxy for results returned by the samtools pileup engine.\n    If the underlying engine iterator advances, the results of this column\n    will change.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_PileupProxy, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_PileupProxy, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  __pyx_pf_9csamtools_11PileupProxy___init__, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_PileupProxy, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_PileupRead(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_PileupRead *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_PileupRead *)o);
-  p->_alignment = ((struct __pyx_obj_9csamtools_AlignedRead *)Py_None); Py_INCREF(Py_None);
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_PileupRead(PyObject *o) {
-  struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
-  Py_XDECREF(((PyObject *)p->_alignment));
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_PileupRead(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
-  if (p->_alignment) {
-    e = (*v)(((PyObject*)p->_alignment), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_PileupRead(PyObject *o) {
-  struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->_alignment);
-  p->_alignment = ((struct __pyx_obj_9csamtools_AlignedRead *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_alignment(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_9alignment___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_qpos(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_4qpos___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_indel(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_5indel___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_del(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_6is_del___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_head(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_7is_head___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_tail(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_7is_tail___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_10PileupRead_level(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_10PileupRead_5level___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_PileupRead[] = {
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_PileupRead[] = {
-  {(char *)"alignment", __pyx_getprop_9csamtools_10PileupRead_alignment, 0, __Pyx_DOCSTR(__pyx_k_157), 0},
-  {(char *)"qpos", __pyx_getprop_9csamtools_10PileupRead_qpos, 0, __Pyx_DOCSTR(__pyx_k_158), 0},
-  {(char *)"indel", __pyx_getprop_9csamtools_10PileupRead_indel, 0, __Pyx_DOCSTR(__pyx_k_159), 0},
-  {(char *)"is_del", __pyx_getprop_9csamtools_10PileupRead_is_del, 0, __Pyx_DOCSTR(__pyx_k_160), 0},
-  {(char *)"is_head", __pyx_getprop_9csamtools_10PileupRead_is_head, 0, 0, 0},
-  {(char *)"is_tail", __pyx_getprop_9csamtools_10PileupRead_is_tail, 0, 0, 0},
-  {(char *)"level", __pyx_getprop_9csamtools_10PileupRead_level, 0, 0, 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_PileupRead = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_PileupRead = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_PileupRead = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_PileupRead = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_PileupRead = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.PileupRead"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_PileupRead), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_PileupRead, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_PileupRead, /*tp_as_number*/
-  &__pyx_tp_as_sequence_PileupRead, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_PileupRead, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  __pyx_pf_9csamtools_10PileupRead___str__, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_PileupRead, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("PileupRead()\nA read aligned to a column.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_PileupRead, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_PileupRead, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_PileupRead, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_PileupRead, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  __pyx_pf_9csamtools_10PileupRead___init__, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_PileupRead, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_Fastafile __pyx_vtable_9csamtools_Fastafile;
-
-static PyObject *__pyx_tp_new_9csamtools_Fastafile(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_Fastafile *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_Fastafile *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_Fastafile;
-  if (__pyx_pf_9csamtools_9Fastafile___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_Fastafile(PyObject *o) {
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_9Fastafile___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9Fastafile_filename(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9Fastafile_8filename___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_Fastafile[] = {
-  {__Pyx_NAMESTR("_isOpen"), (PyCFunction)__pyx_pf_9csamtools_9Fastafile__isOpen, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_9Fastafile__isOpen)},
-  {__Pyx_NAMESTR("_open"), (PyCFunction)__pyx_pf_9csamtools_9Fastafile__open, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_9Fastafile__open)},
-  {__Pyx_NAMESTR("close"), (PyCFunction)__pyx_pf_9csamtools_9Fastafile_close, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_9Fastafile_close)},
-  {__Pyx_NAMESTR("fetch"), (PyCFunction)__pyx_pf_9csamtools_9Fastafile_fetch, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_9Fastafile_fetch)},
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_Fastafile[] = {
-  {(char *)"filename", __pyx_getprop_9csamtools_9Fastafile_filename, 0, __Pyx_DOCSTR(__pyx_k_148), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_Fastafile = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_Fastafile = {
-  __pyx_pf_9csamtools_9Fastafile___len__, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_Fastafile = {
-  __pyx_pf_9csamtools_9Fastafile___len__, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_Fastafile = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_Fastafile = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.Fastafile"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_Fastafile), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_Fastafile, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_Fastafile, /*tp_as_number*/
-  &__pyx_tp_as_sequence_Fastafile, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_Fastafile, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_Fastafile, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("*(filename)*\n              \n    A *FASTA* file. The file is automatically opened.\n\n    The file expects an indexed fasta file.\n\n    TODO: \n        add automatic indexing.\n        add function to get sequence names.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_Fastafile, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_Fastafile, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_Fastafile, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorRow(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorRow(PyObject *o) {
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorRow[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorRow = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
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-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorRow = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorRow = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorRow = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorRow = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorRow"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorRow), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorRow, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorRow, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorRow, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorRow, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorRow, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("abstract base class for iterators over mapped reads.\n\n    Various iterators implement different behaviours for wrapping around\n    contig boundaries. Examples include:\n\n    :class:`pysam.IteratorRowRegion`\n        iterate within a single contig and a defined region.\n\n    :class:`pysam.IteratorRowAll`\n        iterate until EOF. This iterator will also include unmapped reads.\n\n    :class:`pysam.IteratorRowAllRefs`\n        iterate over all reads in all reference sequences.\n        \n    The method :meth:`Samfile.fetch` returns an IteratorRow.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorRow, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorRow, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowRegion __pyx_vtable_9csamtools_IteratorRowRegion;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorRowRegion(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorRowRegion *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorRowRegion;
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_17IteratorRowRegion___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorRowRegion(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowRegion *p = (struct __pyx_obj_9csamtools_IteratorRowRegion *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_17IteratorRowRegion___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->samfile));
-  __pyx_tp_dealloc_9csamtools_IteratorRow(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IteratorRowRegion(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IteratorRowRegion *p = (struct __pyx_obj_9csamtools_IteratorRowRegion *)o;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_traverse) {
-    e = __pyx_ptype_9csamtools_IteratorRow->tp_traverse(o, v, a); if (e) return e;
-  }
-  if (p->samfile) {
-    e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IteratorRowRegion(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowRegion *p = (struct __pyx_obj_9csamtools_IteratorRowRegion *)o;
-  PyObject* tmp;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_clear) {
-    __pyx_ptype_9csamtools_IteratorRow->tp_clear(o);
-  }
-  tmp = ((PyObject*)p->samfile);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorRowRegion[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_17IteratorRowRegion___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_17IteratorRowRegion___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorRowRegion = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorRowRegion = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorRowRegion = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorRowRegion = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorRowRegion = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorRowRegion"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorRowRegion), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorRowRegion, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorRowRegion, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorRowRegion, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorRowRegion, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorRowRegion, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(Samfile samfile, int tid, int beg, int end, int reopen = True )*\n\n    iterate over mapped reads in a region.\n\n    By default, the file is re-openend to avoid conflicts between\n    multiple iterators working on the same file. Set *reopen* = False\n    to not re-open *samfile*.\n\n    The samtools iterators assume that the file\n    position between iterations do not change.\n    As a consequence, no two iterators can work\n    on the same file. To permit this, each iterator\n    creates its own file handle by re-opening the\n    file.\n\n    Note that the index will be shared between \n    samfile and the iterator.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorRowRegion, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorRowRegion, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_17IteratorRowRegion___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_17IteratorRowRegion___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorRowRegion, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorRowRegion, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowAll __pyx_vtable_9csamtools_IteratorRowAll;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorRowAll(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorRowAll *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorRowAll *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorRowAll;
-  if (__pyx_pf_9csamtools_14IteratorRowAll___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorRowAll(PyObject *o) {
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_14IteratorRowAll___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  __pyx_tp_dealloc_9csamtools_IteratorRow(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorRowAll[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_14IteratorRowAll___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorRowAll___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorRowAll = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorRowAll = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorRowAll = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorRowAll = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorRowAll = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorRowAll"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorRowAll), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorRowAll, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorRowAll, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorRowAll, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorRowAll, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorRowAll, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("*(Samfile samfile, int reopen = True)*\n\n    iterate over all reads in *samfile*\n\n    By default, the file is re-openend to avoid conflicts between\n    multiple iterators working on the same file. Set *reopen* = False\n    to not re-open *samfile*.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_14IteratorRowAll___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_14IteratorRowAll___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorRowAll, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorRowAll, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorRowAllRefs(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorRowAllRefs *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  p->rowiter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_18IteratorRowAllRefs___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorRowAllRefs(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
-  Py_XDECREF(((PyObject *)p->samfile));
-  Py_XDECREF(((PyObject *)p->rowiter));
-  __pyx_tp_dealloc_9csamtools_IteratorRow(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IteratorRowAllRefs(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_traverse) {
-    e = __pyx_ptype_9csamtools_IteratorRow->tp_traverse(o, v, a); if (e) return e;
-  }
-  if (p->samfile) {
-    e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
-  }
-  if (p->rowiter) {
-    e = (*v)(((PyObject*)p->rowiter), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IteratorRowAllRefs(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
-  PyObject* tmp;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_clear) {
-    __pyx_ptype_9csamtools_IteratorRow->tp_clear(o);
-  }
-  tmp = ((PyObject*)p->samfile);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  tmp = ((PyObject*)p->rowiter);
-  p->rowiter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorRowAllRefs[] = {
-  {__Pyx_NAMESTR("nextiter"), (PyCFunction)__pyx_pf_9csamtools_18IteratorRowAllRefs_nextiter, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_18IteratorRowAllRefs_nextiter)},
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_18IteratorRowAllRefs___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_18IteratorRowAllRefs___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorRowAllRefs = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorRowAllRefs = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorRowAllRefs = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorRowAllRefs = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorRowAllRefs = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorRowAllRefs"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorRowAllRefs), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorRowAllRefs, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorRowAllRefs, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorRowAllRefs, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorRowAllRefs, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorRowAllRefs, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("iterates over all mapped reads by chaining iterators over each reference\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorRowAllRefs, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorRowAllRefs, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_18IteratorRowAllRefs___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_18IteratorRowAllRefs___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorRowAllRefs, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorRowAllRefs, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorRowSelection __pyx_vtable_9csamtools_IteratorRowSelection;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorRowSelection(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorRowSelection *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorRowSelection *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorRowSelection;
-  p->positions = Py_None; Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_20IteratorRowSelection___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorRowSelection(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_20IteratorRowSelection___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(p->positions);
-  __pyx_tp_dealloc_9csamtools_IteratorRow(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IteratorRowSelection(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_traverse) {
-    e = __pyx_ptype_9csamtools_IteratorRow->tp_traverse(o, v, a); if (e) return e;
-  }
-  if (p->positions) {
-    e = (*v)(p->positions, a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IteratorRowSelection(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
-  PyObject* tmp;
-  if (__pyx_ptype_9csamtools_IteratorRow->tp_clear) {
-    __pyx_ptype_9csamtools_IteratorRow->tp_clear(o);
-  }
-  tmp = ((PyObject*)p->positions);
-  p->positions = Py_None; Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorRowSelection[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_20IteratorRowSelection___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_20IteratorRowSelection___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorRowSelection = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorRowSelection = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorRowSelection = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorRowSelection = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorRowSelection = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorRowSelection"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorRowSelection), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorRowSelection, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorRowSelection, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorRowSelection, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorRowSelection, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorRowSelection, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(Samfile samfile)*\n\n    iterate over reads in *samfile* at a given list of file positions.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorRowSelection, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorRowSelection, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_20IteratorRowSelection___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_20IteratorRowSelection___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorRowSelection, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorRowSelection, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_vtable_9csamtools_IteratorColumn;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorColumn(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorColumn *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorColumn *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorColumn;
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  p->fastafile = ((struct __pyx_obj_9csamtools_Fastafile *)Py_None); Py_INCREF(Py_None);
-  p->stepper = Py_None; Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_14IteratorColumn___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IteratorColumn(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_14IteratorColumn___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->iter));
-  Py_XDECREF(((PyObject *)p->samfile));
-  Py_XDECREF(((PyObject *)p->fastafile));
-  Py_XDECREF(p->stepper);
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IteratorColumn(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
-  if (p->iter) {
-    e = (*v)(((PyObject*)p->iter), a); if (e) return e;
-  }
-  if (p->samfile) {
-    e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
-  }
-  if (p->fastafile) {
-    e = (*v)(((PyObject*)p->fastafile), a); if (e) return e;
-  }
-  if (p->stepper) {
-    e = (*v)(p->stepper, a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IteratorColumn(PyObject *o) {
-  struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->iter);
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  tmp = ((PyObject*)p->samfile);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  tmp = ((PyObject*)p->fastafile);
-  p->fastafile = ((struct __pyx_obj_9csamtools_Fastafile *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  tmp = ((PyObject*)p->stepper);
-  p->stepper = Py_None; Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyObject *__pyx_getprop_9csamtools_14IteratorColumn_seq_len(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_14IteratorColumn_7seq_len___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorColumn[] = {
-  {__Pyx_NAMESTR("addReference"), (PyCFunction)__pyx_pf_9csamtools_14IteratorColumn_addReference, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorColumn_addReference)},
-  {__Pyx_NAMESTR("hasReference"), (PyCFunction)__pyx_pf_9csamtools_14IteratorColumn_hasReference, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorColumn_hasReference)},
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_IteratorColumn[] = {
-  {(char *)"seq_len", __pyx_getprop_9csamtools_14IteratorColumn_seq_len, 0, __Pyx_DOCSTR(__pyx_k_161), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorColumn = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorColumn = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorColumn = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorColumn = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorColumn = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorColumn"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorColumn), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorColumn, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorColumn, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorColumn, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorColumn, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("abstract base class for iterators over columns.\n\n    IteratorColumn objects wrap the pileup functionality of samtools.\n    \n    For reasons of efficiency, the iterator points to the current \n    pileup buffer. The pileup buffer is updated at every iteration.\n    This might cause some unexpected behavious. For example,\n    consider the conversion to a list::\n    \n       f = Samfile(\"file.bam\", \"rb\")\n       result = list( f.pileup() )\n\n    Here, ``result`` will contain ``n`` objects of type :class:`PileupProxy` for ``n`` columns, \n    but each object in ``result`` will contain the same information.\n    \n    The desired behaviour can be achieved by list comprehension::\n\n       result = [ x.pileups() for x in f.pileup() ]\n\n    ``result`` will be a list of ``n`` lists of objects of type :class:`PileupRead`.\n\n    If the iterator is associated with a :class:`Fastafile` using the :meth:`addReference`\n    method, then the iterator will export the current sequence via the methods :meth:`getSequence`\n    and :meth:`seq_len`.\n\n    Optional kwargs to the iterator\n\n    stepper\n       The stepper controlls how the iterator advances. \n       Possible options for the stepper are \n       \n       all\n           use all reads for pileup.\n       samtools\n           same filter and read processing as in :term:`csamtools` pileup\n    fastafile\n       A :class:`FastaFile` object\n    mask\n       Skip all reads with bits set in mask.\n       \n    \n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_14IteratorColumn___iter__, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorColumn, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_IteratorColumn, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorColumn, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion __pyx_vtable_9csamtools_IteratorColumnRegion;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorColumnRegion(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorColumnRegion *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorColumn(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorColumnRegion *)o);
-  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_IteratorColumn*)__pyx_vtabptr_9csamtools_IteratorColumnRegion;
-  if (__pyx_pf_9csamtools_20IteratorColumnRegion___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorColumnRegion[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_20IteratorColumnRegion___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_20IteratorColumnRegion___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorColumnRegion = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorColumnRegion = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorColumnRegion = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorColumnRegion = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorColumnRegion = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorColumnRegion"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorColumnRegion), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorColumnRegion, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorColumnRegion, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorColumnRegion, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorColumnRegion, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("iterates over a region only.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  __pyx_pf_9csamtools_20IteratorColumnRegion___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorColumnRegion, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorColumnRegion, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorColumnAllRefs __pyx_vtable_9csamtools_IteratorColumnAllRefs;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorColumnAllRefs(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorColumnAllRefs *p;
-  PyObject *o = __pyx_tp_new_9csamtools_IteratorColumn(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorColumnAllRefs *)o);
-  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_IteratorColumn*)__pyx_vtabptr_9csamtools_IteratorColumnAllRefs;
-  if (__pyx_pf_9csamtools_21IteratorColumnAllRefs___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorColumnAllRefs[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_21IteratorColumnAllRefs___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_21IteratorColumnAllRefs___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorColumnAllRefs = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
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-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
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-  #endif
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-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
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-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
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-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
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-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorColumnAllRefs = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorColumnAllRefs = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorColumnAllRefs = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorColumnAllRefs = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorColumnAllRefs"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorColumnAllRefs), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorColumnAllRefs, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorColumnAllRefs, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorColumnAllRefs, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorColumnAllRefs, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("iterates over all columns by chaining iterators over each reference\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  __pyx_pf_9csamtools_21IteratorColumnAllRefs___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorColumnAllRefs, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorColumnAllRefs, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_SNPCall(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_SNPCall(PyObject *o) {
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_tid(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_3tid___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_pos(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_3pos___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_reference_base(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_14reference_base___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_genotype(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_8genotype___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_consensus_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_17consensus_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_snp_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_11snp_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_mapping_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_15mapping_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_7SNPCall_coverage(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_7SNPCall_8coverage___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_SNPCall[] = {
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_SNPCall[] = {
-  {(char *)"tid", __pyx_getprop_9csamtools_7SNPCall_tid, 0, __Pyx_DOCSTR(__pyx_k_154), 0},
-  {(char *)"pos", __pyx_getprop_9csamtools_7SNPCall_pos, 0, __Pyx_DOCSTR(__pyx_k_162), 0},
-  {(char *)"reference_base", __pyx_getprop_9csamtools_7SNPCall_reference_base, 0, __Pyx_DOCSTR(__pyx_k_163), 0},
-  {(char *)"genotype", __pyx_getprop_9csamtools_7SNPCall_genotype, 0, __Pyx_DOCSTR(__pyx_k_164), 0},
-  {(char *)"consensus_quality", __pyx_getprop_9csamtools_7SNPCall_consensus_quality, 0, __Pyx_DOCSTR(__pyx_k_165), 0},
-  {(char *)"snp_quality", __pyx_getprop_9csamtools_7SNPCall_snp_quality, 0, __Pyx_DOCSTR(__pyx_k_166), 0},
-  {(char *)"mapping_quality", __pyx_getprop_9csamtools_7SNPCall_mapping_quality, 0, __Pyx_DOCSTR(__pyx_k_167), 0},
-  {(char *)"coverage", __pyx_getprop_9csamtools_7SNPCall_coverage, 0, __Pyx_DOCSTR(__pyx_k_168), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_SNPCall = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_SNPCall = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_SNPCall = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_SNPCall = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_SNPCall = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.SNPCall"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_SNPCall), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_SNPCall, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_SNPCall, /*tp_as_number*/
-  &__pyx_tp_as_sequence_SNPCall, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_SNPCall, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  __pyx_pf_9csamtools_7SNPCall___str__, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_SNPCall, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("the results of a SNP call."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_SNPCall, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_SNPCall, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_SNPCall, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_SNPCallerBase __pyx_vtable_9csamtools_SNPCallerBase;
-
-static PyObject *__pyx_tp_new_9csamtools_SNPCallerBase(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_SNPCallerBase *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_SNPCallerBase *)o);
-  p->__pyx_vtab = __pyx_vtabptr_9csamtools_SNPCallerBase;
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_13SNPCallerBase___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_SNPCallerBase(PyObject *o) {
-  struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_13SNPCallerBase___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->iter));
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_SNPCallerBase(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
-  if (p->iter) {
-    e = (*v)(((PyObject*)p->iter), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_SNPCallerBase(PyObject *o) {
-  struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->iter);
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_SNPCallerBase[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_SNPCallerBase = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_SNPCallerBase = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_SNPCallerBase = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_SNPCallerBase = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_SNPCallerBase = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.SNPCallerBase"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_SNPCallerBase), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_SNPCallerBase, /*tp_as_number*/
-  &__pyx_tp_as_sequence_SNPCallerBase, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_SNPCallerBase, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_SNPCallerBase, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("Base class for SNP callers.\n\n    *min_baseQ*\n       minimum base quality (possibly capped by BAQ)\n    *capQ_threshold*\n       coefficient for adjusting mapQ of poor mappings\n    *theta*\n       theta in maq consensus calling model\n    *n_haplotypes*\n       number of haplotypes in the sample\n    *het_rate*\n       prior of a difference between two haplotypes\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_SNPCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_SNPCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_SNPCallerBase, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_SNPCallerBase, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_IteratorSNPCalls __pyx_vtable_9csamtools_IteratorSNPCalls;
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorSNPCalls(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IteratorSNPCalls *p;
-  PyObject *o = __pyx_tp_new_9csamtools_SNPCallerBase(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)o);
-  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_SNPCallerBase*)__pyx_vtabptr_9csamtools_IteratorSNPCalls;
-  if (__pyx_pf_9csamtools_16IteratorSNPCalls___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorSNPCalls[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_16IteratorSNPCalls___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_16IteratorSNPCalls___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorSNPCalls = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorSNPCalls = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorSNPCalls = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorSNPCalls = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorSNPCalls = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorSNPCalls"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorSNPCalls), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorSNPCalls, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorSNPCalls, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorSNPCalls, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorSNPCalls, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(IteratorColumn iterator)*\n\n    call SNPs within a region.\n\n    *iterator* is a pileup iterator. SNPs will be called\n    on all positions returned by this iterator.\n\n    This caller is fast if SNPs are called over large continuous\n    regions. It is slow, if instantiated frequently and in random\n    order as the sequence will have to be reloaded.\n\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_SNPCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_SNPCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_16IteratorSNPCalls___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_16IteratorSNPCalls___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorSNPCalls, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorSNPCalls, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-static struct __pyx_vtabstruct_9csamtools_SNPCaller __pyx_vtable_9csamtools_SNPCaller;
-
-static PyObject *__pyx_tp_new_9csamtools_SNPCaller(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_SNPCaller *p;
-  PyObject *o = __pyx_tp_new_9csamtools_SNPCallerBase(t, a, k);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_SNPCaller *)o);
-  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_SNPCallerBase*)__pyx_vtabptr_9csamtools_SNPCaller;
-  if (__pyx_pf_9csamtools_9SNPCaller___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_SNPCaller[] = {
-  {__Pyx_NAMESTR("call"), (PyCFunction)__pyx_pf_9csamtools_9SNPCaller_call, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_9SNPCaller_call)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_SNPCaller = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_SNPCaller = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_SNPCaller = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_SNPCaller = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_SNPCaller = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.SNPCaller"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_SNPCaller), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_SNPCaller, /*tp_as_number*/
-  &__pyx_tp_as_sequence_SNPCaller, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_SNPCaller, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_SNPCaller, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(IteratorColumn iterator_column )*\n\n    The samtools SNP caller.\n\n    This object will call SNPs in *samfile* against the reference\n    sequence in *fasta*.\n\n    This caller is fast for calling few SNPs in selected regions.\n\n    It is slow, if called over large genomic regions.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_SNPCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_SNPCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_SNPCaller, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_SNPCaller, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IndelCall(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  if (__pyx_pf_9csamtools_9IndelCall___cinit__(o, __pyx_empty_tuple, NULL) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IndelCall(PyObject *o) {
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_9IndelCall___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_tid(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_3tid___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_pos(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_3pos___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_genotype(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_8genotype___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_consensus_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_17consensus_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_snp_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_11snp_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_mapping_quality(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_15mapping_quality___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_coverage(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_8coverage___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_first_allele(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_12first_allele___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_second_allele(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_13second_allele___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_reads_first(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_11reads_first___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_reads_second(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_12reads_second___get__(o);
-}
-
-static PyObject *__pyx_getprop_9csamtools_9IndelCall_reads_diff(PyObject *o, void *x) {
-  return __pyx_pf_9csamtools_9IndelCall_10reads_diff___get__(o);
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IndelCall[] = {
-  {0, 0, 0, 0}
-};
-
-static struct PyGetSetDef __pyx_getsets_9csamtools_IndelCall[] = {
-  {(char *)"tid", __pyx_getprop_9csamtools_9IndelCall_tid, 0, __Pyx_DOCSTR(__pyx_k_154), 0},
-  {(char *)"pos", __pyx_getprop_9csamtools_9IndelCall_pos, 0, __Pyx_DOCSTR(__pyx_k_162), 0},
-  {(char *)"genotype", __pyx_getprop_9csamtools_9IndelCall_genotype, 0, __Pyx_DOCSTR(__pyx_k_164), 0},
-  {(char *)"consensus_quality", __pyx_getprop_9csamtools_9IndelCall_consensus_quality, 0, __Pyx_DOCSTR(__pyx_k_165), 0},
-  {(char *)"snp_quality", __pyx_getprop_9csamtools_9IndelCall_snp_quality, 0, __Pyx_DOCSTR(__pyx_k_166), 0},
-  {(char *)"mapping_quality", __pyx_getprop_9csamtools_9IndelCall_mapping_quality, 0, __Pyx_DOCSTR(__pyx_k_167), 0},
-  {(char *)"coverage", __pyx_getprop_9csamtools_9IndelCall_coverage, 0, __Pyx_DOCSTR(__pyx_k_168), 0},
-  {(char *)"first_allele", __pyx_getprop_9csamtools_9IndelCall_first_allele, 0, __Pyx_DOCSTR(__pyx_k_169), 0},
-  {(char *)"second_allele", __pyx_getprop_9csamtools_9IndelCall_second_allele, 0, __Pyx_DOCSTR(__pyx_k_170), 0},
-  {(char *)"reads_first", __pyx_getprop_9csamtools_9IndelCall_reads_first, 0, __Pyx_DOCSTR(__pyx_k_171), 0},
-  {(char *)"reads_second", __pyx_getprop_9csamtools_9IndelCall_reads_second, 0, __Pyx_DOCSTR(__pyx_k_171), 0},
-  {(char *)"reads_diff", __pyx_getprop_9csamtools_9IndelCall_reads_diff, 0, __Pyx_DOCSTR(__pyx_k_171), 0},
-  {0, 0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IndelCall = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IndelCall = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IndelCall = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IndelCall = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IndelCall = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IndelCall"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IndelCall), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IndelCall, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IndelCall, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IndelCall, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IndelCall, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  __pyx_pf_9csamtools_9IndelCall___str__, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IndelCall, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("the results of an indel call."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IndelCall, /*tp_methods*/
-  0, /*tp_members*/
-  __pyx_getsets_9csamtools_IndelCall, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IndelCall, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IndelCallerBase(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IndelCallerBase *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IndelCallerBase *)o);
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
-  if (__pyx_pf_9csamtools_15IndelCallerBase___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IndelCallerBase(PyObject *o) {
-  struct __pyx_obj_9csamtools_IndelCallerBase *p = (struct __pyx_obj_9csamtools_IndelCallerBase *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_15IndelCallerBase___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->iter));
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IndelCallerBase(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IndelCallerBase *p = (struct __pyx_obj_9csamtools_IndelCallerBase *)o;
-  if (p->iter) {
-    e = (*v)(((PyObject*)p->iter), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IndelCallerBase(PyObject *o) {
-  struct __pyx_obj_9csamtools_IndelCallerBase *p = (struct __pyx_obj_9csamtools_IndelCallerBase *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->iter);
-  p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IndelCallerBase[] = {
-  {__Pyx_NAMESTR("_call"), (PyCFunction)__pyx_pf_9csamtools_15IndelCallerBase__call, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_15IndelCallerBase__call)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IndelCallerBase = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IndelCallerBase = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IndelCallerBase = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IndelCallerBase = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IndelCallerBase = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IndelCallerBase"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IndelCallerBase), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IndelCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IndelCallerBase, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IndelCallerBase, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IndelCallerBase, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IndelCallerBase, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("Base class for SNP callers.\n\n    *min_baseQ*\n       minimum base quality (possibly capped by BAQ)\n    *capQ_threshold*\n       coefficient for adjusting mapQ of poor mappings\n    *theta*\n       theta in maq consensus calling model\n    *n_haplotypes*\n       number of haplotypes in the sample\n    *het_rate*\n       prior of a difference between two haplotypes\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IndelCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IndelCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IndelCallerBase, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IndelCallerBase, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IndelCaller(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_9csamtools_IndelCallerBase(t, a, k);
-  if (!o) return 0;
-  if (__pyx_pf_9csamtools_11IndelCaller___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IndelCaller[] = {
-  {__Pyx_NAMESTR("call"), (PyCFunction)__pyx_pf_9csamtools_11IndelCaller_call, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_11IndelCaller_call)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IndelCaller = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IndelCaller = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IndelCaller = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IndelCaller = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IndelCaller = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IndelCaller"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IndelCaller), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IndelCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IndelCaller, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IndelCaller, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IndelCaller, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IndelCaller, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(IteratorColumn iterator_column )*\n\n    The samtools SNP caller.\n\n    This object will call SNPs in *samfile* against the reference\n    sequence in *fasta*.\n\n    This caller is fast for calling few SNPs in selected regions.\n\n    It is slow, if called over large genomic regions.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IndelCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IndelCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IndelCaller, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IndelCaller, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IteratorIndelCalls(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_9csamtools_IndelCallerBase(t, a, k);
-  if (!o) return 0;
-  if (__pyx_pf_9csamtools_18IteratorIndelCalls___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IteratorIndelCalls[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_18IteratorIndelCalls___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_18IteratorIndelCalls___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IteratorIndelCalls = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IteratorIndelCalls = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IteratorIndelCalls = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IteratorIndelCalls = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IteratorIndelCalls = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IteratorIndelCalls"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IteratorIndelCalls), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IndelCallerBase, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IteratorIndelCalls, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IteratorIndelCalls, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IteratorIndelCalls, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IteratorIndelCalls, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("*(IteratorColumn iterator)*\n\n    call indels within a region.\n\n    *iterator* is a pileup iterator. SNPs will be called\n    on all positions returned by this iterator.\n\n    This caller is fast if SNPs are called over large continuous\n    regions. It is slow, if instantiated frequently and in random\n    order as the sequence will have to be reloaded.\n\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IndelCallerBase, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IndelCallerBase, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_9csamtools_18IteratorIndelCalls___iter__, /*tp_iter*/
-  __pyx_pf_9csamtools_18IteratorIndelCalls___next__, /*tp_iternext*/
-  __pyx_methods_9csamtools_IteratorIndelCalls, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_9csamtools_IteratorIndelCalls, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_9csamtools_IndexedReads(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_9csamtools_IndexedReads *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_9csamtools_IndexedReads *)o);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  p->index = Py_None; Py_INCREF(Py_None);
-  return o;
-}
-
-static void __pyx_tp_dealloc_9csamtools_IndexedReads(PyObject *o) {
-  struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_9csamtools_12IndexedReads___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->samfile));
-  Py_XDECREF(p->index);
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_9csamtools_IndexedReads(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
-  if (p->samfile) {
-    e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
-  }
-  if (p->index) {
-    e = (*v)(p->index, a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_9csamtools_IndexedReads(PyObject *o) {
-  struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->samfile);
-  p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  tmp = ((PyObject*)p->index);
-  p->index = Py_None; Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_9csamtools_IndexedReads[] = {
-  {__Pyx_NAMESTR("build"), (PyCFunction)__pyx_pf_9csamtools_12IndexedReads_build, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_12IndexedReads_build)},
-  {__Pyx_NAMESTR("find"), (PyCFunction)__pyx_pf_9csamtools_12IndexedReads_find, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_12IndexedReads_find)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_IndexedReads = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_IndexedReads = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_IndexedReads = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_IndexedReads = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_9csamtools_IndexedReads = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("csamtools.IndexedReads"), /*tp_name*/
-  sizeof(struct __pyx_obj_9csamtools_IndexedReads), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_9csamtools_IndexedReads, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_IndexedReads, /*tp_as_number*/
-  &__pyx_tp_as_sequence_IndexedReads, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_IndexedReads, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_IndexedReads, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
-  __Pyx_DOCSTR("IndexedReads(Samfile samfile, int reopen=True)\nindex a bamfile by read.\n\n    The index is kept in memory.\n\n    By default, the file is re-openend to avoid conflicts if\n    multiple operators work on the same file. Set *reopen* = False\n    to not re-open *samfile*.\n    "), /*tp_doc*/
-  __pyx_tp_traverse_9csamtools_IndexedReads, /*tp_traverse*/
-  __pyx_tp_clear_9csamtools_IndexedReads, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_9csamtools_IndexedReads, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
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-  {&__pyx_n_s__hash, __pyx_k__hash, sizeof(__pyx_k__hash), 0, 0, 1, 1},
-  {&__pyx_n_s__header, __pyx_k__header, sizeof(__pyx_k__header), 0, 0, 1, 1},
-  {&__pyx_n_s__het_rate, __pyx_k__het_rate, sizeof(__pyx_k__het_rate), 0, 0, 1, 1},
-  {&__pyx_n_s__i, __pyx_k__i, sizeof(__pyx_k__i), 0, 0, 1, 1},
-  {&__pyx_n_s__id, __pyx_k__id, sizeof(__pyx_k__id), 0, 0, 1, 1},
-  {&__pyx_n_s__indel, __pyx_k__indel, sizeof(__pyx_k__indel), 0, 0, 1, 1},
-  {&__pyx_n_s__indel1, __pyx_k__indel1, sizeof(__pyx_k__indel1), 0, 0, 1, 1},
-  {&__pyx_n_s__indel2, __pyx_k__indel2, sizeof(__pyx_k__indel2), 0, 0, 1, 1},
-  {&__pyx_n_s__index, __pyx_k__index, sizeof(__pyx_k__index), 0, 0, 1, 1},
-  {&__pyx_n_s__is_del, __pyx_k__is_del, sizeof(__pyx_k__is_del), 0, 0, 1, 1},
-  {&__pyx_n_s__is_head, __pyx_k__is_head, sizeof(__pyx_k__is_head), 0, 0, 1, 1},
-  {&__pyx_n_s__is_tail, __pyx_k__is_tail, sizeof(__pyx_k__is_tail), 0, 0, 1, 1},
-  {&__pyx_n_s__isbam, __pyx_k__isbam, sizeof(__pyx_k__isbam), 0, 0, 1, 1},
-  {&__pyx_n_s__isize, __pyx_k__isize, sizeof(__pyx_k__isize), 0, 0, 1, 1},
-  {&__pyx_n_s__isremote, __pyx_k__isremote, sizeof(__pyx_k__isremote), 0, 0, 1, 1},
-  {&__pyx_n_s__isupper, __pyx_k__isupper, sizeof(__pyx_k__isupper), 0, 0, 1, 1},
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-  {&__pyx_n_s__iterator_column, __pyx_k__iterator_column, sizeof(__pyx_k__iterator_column), 0, 0, 1, 1},
-  {&__pyx_n_s__iterdata, __pyx_k__iterdata, sizeof(__pyx_k__iterdata), 0, 0, 1, 1},
-  {&__pyx_n_s__itertools, __pyx_k__itertools, sizeof(__pyx_k__itertools), 0, 0, 1, 1},
-  {&__pyx_n_s__join, __pyx_k__join, sizeof(__pyx_k__join), 0, 0, 1, 1},
-  {&__pyx_n_s__l_aux, __pyx_k__l_aux, sizeof(__pyx_k__l_aux), 0, 0, 1, 1},
-  {&__pyx_n_s__l_qname, __pyx_k__l_qname, sizeof(__pyx_k__l_qname), 0, 0, 1, 1},
-  {&__pyx_n_s__l_qseq, __pyx_k__l_qseq, sizeof(__pyx_k__l_qseq), 0, 0, 1, 1},
-  {&__pyx_n_s__l_text, __pyx_k__l_text, sizeof(__pyx_k__l_text), 0, 0, 1, 1},
-  {&__pyx_n_s__level, __pyx_k__level, sizeof(__pyx_k__level), 0, 0, 1, 1},
-  {&__pyx_n_s__m_data, __pyx_k__m_data, sizeof(__pyx_k__m_data), 0, 0, 1, 1},
-  {&__pyx_n_s__map, __pyx_k__map, sizeof(__pyx_k__map), 0, 0, 1, 1},
-  {&__pyx_n_s__mapping_quality, __pyx_k__mapping_quality, sizeof(__pyx_k__mapping_quality), 0, 0, 1, 1},
-  {&__pyx_n_s__mapq, __pyx_k__mapq, sizeof(__pyx_k__mapq), 0, 0, 1, 1},
-  {&__pyx_n_s__mask, __pyx_k__mask, sizeof(__pyx_k__mask), 0, 0, 1, 1},
-  {&__pyx_n_s__mate, __pyx_k__mate, sizeof(__pyx_k__mate), 0, 0, 1, 1},
-  {&__pyx_n_s__max_depth, __pyx_k__max_depth, sizeof(__pyx_k__max_depth), 0, 0, 1, 1},
-  {&__pyx_n_s__method, __pyx_k__method, sizeof(__pyx_k__method), 0, 0, 1, 1},
-  {&__pyx_n_s__min_baseQ, __pyx_k__min_baseQ, sizeof(__pyx_k__min_baseQ), 0, 0, 1, 1},
-  {&__pyx_n_s__mkstemp, __pyx_k__mkstemp, sizeof(__pyx_k__mkstemp), 0, 0, 1, 1},
-  {&__pyx_n_s__mode, __pyx_k__mode, sizeof(__pyx_k__mode), 0, 0, 1, 1},
-  {&__pyx_n_s__mpos, __pyx_k__mpos, sizeof(__pyx_k__mpos), 0, 0, 1, 1},
-  {&__pyx_n_s__mrnm, __pyx_k__mrnm, sizeof(__pyx_k__mrnm), 0, 0, 1, 1},
-  {&__pyx_n_s__mtid, __pyx_k__mtid, sizeof(__pyx_k__mtid), 0, 0, 1, 1},
-  {&__pyx_n_s__n, __pyx_k__n, sizeof(__pyx_k__n), 0, 0, 1, 1},
-  {&__pyx_n_s__n_cigar, __pyx_k__n_cigar, sizeof(__pyx_k__n_cigar), 0, 0, 1, 1},
-  {&__pyx_n_s__n_hap, __pyx_k__n_hap, sizeof(__pyx_k__n_hap), 0, 0, 1, 1},
-  {&__pyx_n_s__n_haplotypes, __pyx_k__n_haplotypes, sizeof(__pyx_k__n_haplotypes), 0, 0, 1, 1},
-  {&__pyx_n_s__n_plp, __pyx_k__n_plp, sizeof(__pyx_k__n_plp), 0, 0, 1, 1},
-  {&__pyx_n_s__n_pu, __pyx_k__n_pu, sizeof(__pyx_k__n_pu), 0, 0, 1, 1},
-  {&__pyx_n_s__n_targets, __pyx_k__n_targets, sizeof(__pyx_k__n_targets), 0, 0, 1, 1},
-  {&__pyx_n_s__name, __pyx_k__name, sizeof(__pyx_k__name), 0, 0, 1, 1},
-  {&__pyx_n_s__nextiter, __pyx_k__nextiter, sizeof(__pyx_k__nextiter), 0, 0, 1, 1},
-  {&__pyx_n_s__nreferences, __pyx_k__nreferences, sizeof(__pyx_k__nreferences), 0, 0, 1, 1},
-  {&__pyx_n_s__object, __pyx_k__object, sizeof(__pyx_k__object), 0, 0, 1, 1},
-  {&__pyx_n_s__offset, __pyx_k__offset, sizeof(__pyx_k__offset), 0, 0, 1, 1},
-  {&__pyx_n_s__open, __pyx_k__open, sizeof(__pyx_k__open), 0, 0, 1, 1},
-  {&__pyx_n_s__opt, __pyx_k__opt, sizeof(__pyx_k__opt), 0, 0, 1, 1},
-  {&__pyx_n_s__options, __pyx_k__options, sizeof(__pyx_k__options), 0, 0, 1, 1},
-  {&__pyx_n_s__os, __pyx_k__os, sizeof(__pyx_k__os), 0, 0, 1, 1},
-  {&__pyx_n_s__overlap, __pyx_k__overlap, sizeof(__pyx_k__overlap), 0, 0, 1, 1},
-  {&__pyx_n_s__owns_samfile, __pyx_k__owns_samfile, sizeof(__pyx_k__owns_samfile), 0, 0, 1, 1},
-  {&__pyx_n_s__pack_into, __pyx_k__pack_into, sizeof(__pyx_k__pack_into), 0, 0, 1, 1},
-  {&__pyx_n_s__path, __pyx_k__path, sizeof(__pyx_k__path), 0, 0, 1, 1},
-  {&__pyx_n_s__pileup, __pyx_k__pileup, sizeof(__pyx_k__pileup), 0, 0, 1, 1},
-  {&__pyx_n_s__pileup_iter, __pyx_k__pileup_iter, sizeof(__pyx_k__pileup_iter), 0, 0, 1, 1},
-  {&__pyx_n_s__pileups, __pyx_k__pileups, sizeof(__pyx_k__pileups), 0, 0, 1, 1},
-  {&__pyx_n_s__platform, __pyx_k__platform, sizeof(__pyx_k__platform), 0, 0, 1, 1},
-  {&__pyx_n_s__plp, __pyx_k__plp, sizeof(__pyx_k__plp), 0, 0, 1, 1},
-  {&__pyx_n_s__port, __pyx_k__port, sizeof(__pyx_k__port), 0, 0, 1, 1},
-  {&__pyx_n_s__pos, __pyx_k__pos, sizeof(__pyx_k__pos), 0, 0, 1, 1},
-  {&__pyx_n_s__positions, __pyx_k__positions, sizeof(__pyx_k__positions), 0, 0, 1, 1},
-  {&__pyx_n_s__q_cns, __pyx_k__q_cns, sizeof(__pyx_k__q_cns), 0, 0, 1, 1},
-  {&__pyx_n_s__q_indel, __pyx_k__q_indel, sizeof(__pyx_k__q_indel), 0, 0, 1, 1},
-  {&__pyx_n_s__q_r, __pyx_k__q_r, sizeof(__pyx_k__q_r), 0, 0, 1, 1},
-  {&__pyx_n_s__q_ref, __pyx_k__q_ref, sizeof(__pyx_k__q_ref), 0, 0, 1, 1},
-  {&__pyx_n_s__qname, __pyx_k__qname, sizeof(__pyx_k__qname), 0, 0, 1, 1},
-  {&__pyx_n_s__qpos, __pyx_k__qpos, sizeof(__pyx_k__qpos), 0, 0, 1, 1},
-  {&__pyx_n_s__qseq, __pyx_k__qseq, sizeof(__pyx_k__qseq), 0, 0, 1, 1},
-  {&__pyx_n_s__qual, __pyx_k__qual, sizeof(__pyx_k__qual), 0, 0, 1, 1},
-  {&__pyx_n_s__r, __pyx_k__r, sizeof(__pyx_k__r), 0, 0, 1, 1},
-  {&__pyx_n_s__r_indel, __pyx_k__r_indel, sizeof(__pyx_k__r_indel), 0, 0, 1, 1},
-  {&__pyx_n_s__range, __pyx_k__range, sizeof(__pyx_k__range), 0, 0, 1, 1},
-  {&__pyx_n_s__raw, __pyx_k__raw, sizeof(__pyx_k__raw), 0, 0, 1, 1},
-  {&__pyx_n_s__rb, __pyx_k__rb, sizeof(__pyx_k__rb), 0, 0, 1, 1},
-  {&__pyx_n_s__re, __pyx_k__re, sizeof(__pyx_k__re), 0, 0, 1, 1},
-  {&__pyx_n_s__readAndRelease, __pyx_k__readAndRelease, sizeof(__pyx_k__readAndRelease), 0, 0, 1, 1},
-  {&__pyx_n_s__readlines, __pyx_k__readlines, sizeof(__pyx_k__readlines), 0, 0, 1, 1},
-  {&__pyx_n_s__reads_diff, __pyx_k__reads_diff, sizeof(__pyx_k__reads_diff), 0, 0, 1, 1},
-  {&__pyx_n_s__reads_first, __pyx_k__reads_first, sizeof(__pyx_k__reads_first), 0, 0, 1, 1},
-  {&__pyx_n_s__reads_second, __pyx_k__reads_second, sizeof(__pyx_k__reads_second), 0, 0, 1, 1},
-  {&__pyx_n_s__record, __pyx_k__record, sizeof(__pyx_k__record), 0, 0, 1, 1},
-  {&__pyx_n_s__reference, __pyx_k__reference, sizeof(__pyx_k__reference), 0, 0, 1, 1},
-  {&__pyx_n_s__reference_base, __pyx_k__reference_base, sizeof(__pyx_k__reference_base), 0, 0, 1, 1},
-  {&__pyx_n_s__referencelengths, __pyx_k__referencelengths, sizeof(__pyx_k__referencelengths), 0, 0, 1, 1},
-  {&__pyx_n_s__referencenames, __pyx_k__referencenames, sizeof(__pyx_k__referencenames), 0, 0, 1, 1},
-  {&__pyx_n_s__region, __pyx_k__region, sizeof(__pyx_k__region), 0, 0, 1, 1},
-  {&__pyx_n_s__release, __pyx_k__release, sizeof(__pyx_k__release), 0, 0, 1, 1},
-  {&__pyx_n_s__remove, __pyx_k__remove, sizeof(__pyx_k__remove), 0, 0, 1, 1},
-  {&__pyx_n_s__reopen, __pyx_k__reopen, sizeof(__pyx_k__reopen), 0, 0, 1, 1},
-  {&__pyx_n_s__reset, __pyx_k__reset, sizeof(__pyx_k__reset), 0, 0, 1, 1},
-  {&__pyx_n_s__restore, __pyx_k__restore, sizeof(__pyx_k__restore), 0, 0, 1, 1},
-  {&__pyx_n_s__retval, __pyx_k__retval, sizeof(__pyx_k__retval), 0, 0, 1, 1},
-  {&__pyx_n_s__rg2lib, __pyx_k__rg2lib, sizeof(__pyx_k__rg2lib), 0, 0, 1, 1},
-  {&__pyx_n_s__rlen, __pyx_k__rlen, sizeof(__pyx_k__rlen), 0, 0, 1, 1},
-  {&__pyx_n_s__rname, __pyx_k__rname, sizeof(__pyx_k__rname), 0, 0, 1, 1},
-  {&__pyx_n_s__rowiter, __pyx_k__rowiter, sizeof(__pyx_k__rowiter), 0, 0, 1, 1},
-  {&__pyx_n_s__s, __pyx_k__s, sizeof(__pyx_k__s), 0, 0, 1, 1},
-  {&__pyx_n_s__samfile, __pyx_k__samfile, sizeof(__pyx_k__samfile), 0, 0, 1, 1},
-  {&__pyx_n_s__samtools, __pyx_k__samtools, sizeof(__pyx_k__samtools), 0, 0, 1, 1},
-  {&__pyx_n_s__second_allele, __pyx_k__second_allele, sizeof(__pyx_k__second_allele), 0, 0, 1, 1},
-  {&__pyx_n_s__seek, __pyx_k__seek, sizeof(__pyx_k__seek), 0, 0, 1, 1},
-  {&__pyx_n_s__self, __pyx_k__self, sizeof(__pyx_k__self), 0, 0, 1, 1},
-  {&__pyx_n_s__seq, __pyx_k__seq, sizeof(__pyx_k__seq), 0, 0, 1, 1},
-  {&__pyx_n_s__seq_len, __pyx_k__seq_len, sizeof(__pyx_k__seq_len), 0, 0, 1, 1},
-  {&__pyx_n_s__setdevice, __pyx_k__setdevice, sizeof(__pyx_k__setdevice), 0, 0, 1, 1},
-  {&__pyx_n_s__setfd, __pyx_k__setfd, sizeof(__pyx_k__setfd), 0, 0, 1, 1},
-  {&__pyx_n_s__setfile, __pyx_k__setfile, sizeof(__pyx_k__setfile), 0, 0, 1, 1},
-  {&__pyx_n_s__setupIteratorData, __pyx_k__setupIteratorData, sizeof(__pyx_k__setupIteratorData), 0, 0, 1, 1},
-  {&__pyx_n_s__snp_quality, __pyx_k__snp_quality, sizeof(__pyx_k__snp_quality), 0, 0, 1, 1},
-  {&__pyx_n_s__split, __pyx_k__split, sizeof(__pyx_k__split), 0, 0, 1, 1},
-  {&__pyx_n_s__start, __pyx_k__start, sizeof(__pyx_k__start), 0, 0, 1, 1},
-  {&__pyx_n_s__startswith, __pyx_k__startswith, sizeof(__pyx_k__startswith), 0, 0, 1, 1},
-  {&__pyx_n_s__stderr, __pyx_k__stderr, sizeof(__pyx_k__stderr), 0, 0, 1, 1},
-  {&__pyx_n_s__stderr_f, __pyx_k__stderr_f, sizeof(__pyx_k__stderr_f), 0, 0, 1, 1},
-  {&__pyx_n_s__stderr_h, __pyx_k__stderr_h, sizeof(__pyx_k__stderr_h), 0, 0, 1, 1},
-  {&__pyx_n_s__stderr_save, __pyx_k__stderr_save, sizeof(__pyx_k__stderr_save), 0, 0, 1, 1},
-  {&__pyx_n_s__stdout, __pyx_k__stdout, sizeof(__pyx_k__stdout), 0, 0, 1, 1},
-  {&__pyx_n_s__stepper, __pyx_k__stepper, sizeof(__pyx_k__stepper), 0, 0, 1, 1},
-  {&__pyx_n_s__streams, __pyx_k__streams, sizeof(__pyx_k__streams), 0, 0, 1, 1},
-  {&__pyx_n_s__strip, __pyx_k__strip, sizeof(__pyx_k__strip), 0, 0, 1, 1},
-  {&__pyx_n_s__struct, __pyx_k__struct, sizeof(__pyx_k__struct), 0, 0, 1, 1},
-  {&__pyx_n_s__sys, __pyx_k__sys, sizeof(__pyx_k__sys), 0, 0, 1, 1},
-  {&__pyx_n_s__system, __pyx_k__system, sizeof(__pyx_k__system), 0, 0, 1, 1},
-  {&__pyx_n_s__tags, __pyx_k__tags, sizeof(__pyx_k__tags), 0, 0, 1, 1},
-  {&__pyx_n_s__target_len, __pyx_k__target_len, sizeof(__pyx_k__target_len), 0, 0, 1, 1},
-  {&__pyx_n_s__target_name, __pyx_k__target_name, sizeof(__pyx_k__target_name), 0, 0, 1, 1},
-  {&__pyx_n_s__tell, __pyx_k__tell, sizeof(__pyx_k__tell), 0, 0, 1, 1},
-  {&__pyx_n_s__tempfile, __pyx_k__tempfile, sizeof(__pyx_k__tempfile), 0, 0, 1, 1},
-  {&__pyx_n_s__template, __pyx_k__template, sizeof(__pyx_k__template), 0, 0, 1, 1},
-  {&__pyx_n_s__text, __pyx_k__text, sizeof(__pyx_k__text), 0, 0, 1, 1},
-  {&__pyx_n_s__theta, __pyx_k__theta, sizeof(__pyx_k__theta), 0, 0, 1, 1},
-  {&__pyx_n_s__tid, __pyx_k__tid, sizeof(__pyx_k__tid), 0, 0, 1, 1},
-  {&__pyx_n_s__traceback, __pyx_k__traceback, sizeof(__pyx_k__traceback), 0, 0, 1, 1},
-  {&__pyx_n_s__types, __pyx_k__types, sizeof(__pyx_k__types), 0, 0, 1, 1},
-  {&__pyx_n_s__until_eof, __pyx_k__until_eof, sizeof(__pyx_k__until_eof), 0, 0, 1, 1},
-  {&__pyx_n_s__view, __pyx_k__view, sizeof(__pyx_k__view), 0, 0, 1, 1},
-  {&__pyx_n_s__w, __pyx_k__w, sizeof(__pyx_k__w), 0, 0, 1, 1},
-  {&__pyx_n_s__wb, __pyx_k__wb, sizeof(__pyx_k__wb), 0, 0, 1, 1},
-  {&__pyx_n_s__wbu, __pyx_k__wbu, sizeof(__pyx_k__wbu), 0, 0, 1, 1},
-  {&__pyx_n_s__wh, __pyx_k__wh, sizeof(__pyx_k__wh), 0, 0, 1, 1},
-  {&__pyx_n_s__where, __pyx_k__where, sizeof(__pyx_k__where), 0, 0, 1, 1},
-  {&__pyx_n_s__write, __pyx_k__write, sizeof(__pyx_k__write), 0, 0, 1, 1},
-  {&__pyx_n_s__x, __pyx_k__x, sizeof(__pyx_k__x), 0, 0, 1, 1},
-  {0, 0, 0, 0, 0, 0, 0}
-};
-static int __Pyx_InitCachedBuiltins(void) {
-  __pyx_builtin_open = __Pyx_GetName(__pyx_b, __pyx_n_s__open); if (!__pyx_builtin_open) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 67; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_builtin_object = __Pyx_GetName(__pyx_b, __pyx_n_s__object); if (!__pyx_builtin_object) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 117; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_builtin_map = __Pyx_GetName(__pyx_b, __pyx_n_s__map); if (!__pyx_builtin_map) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 131; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  __pyx_int_neg_2147483648 = PyInt_FromLong(-2147483648); if (unlikely(!__pyx_int_neg_2147483648)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  return 0;
-  __pyx_L1_error:;
-  return -1;
-}
-
-#if PY_MAJOR_VERSION < 3
-PyMODINIT_FUNC initcsamtools(void); /*proto*/
-PyMODINIT_FUNC initcsamtools(void)
-#else
-PyMODINIT_FUNC PyInit_csamtools(void); /*proto*/
-PyMODINIT_FUNC PyInit_csamtools(void)
-#endif
-{
-  PyObject *__pyx_t_1 = NULL;
-  PyObject *__pyx_t_2 = NULL;
-  PyObject *__pyx_t_3 = NULL;
-  PyObject *__pyx_t_4 = NULL;
-  int __pyx_t_5;
-  #if CYTHON_REFNANNY
-  void* __pyx_refnanny = NULL;
-  __Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
-  if (!__Pyx_RefNanny) {
-      PyErr_Clear();
-      __Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
-      if (!__Pyx_RefNanny)
-          Py_FatalError("failed to import 'refnanny' module");
-  }
-  __pyx_refnanny = __Pyx_RefNanny->SetupContext("PyMODINIT_FUNC PyInit_csamtools(void)", __LINE__, __FILE__);
-  #endif
-  __pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  #ifdef __pyx_binding_PyCFunctionType_USED
-  if (__pyx_binding_PyCFunctionType_init() < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  #endif
-  /*--- Library function declarations ---*/
-  /*--- Threads initialization code ---*/
-  #if defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
-  #ifdef WITH_THREAD /* Python build with threading support? */
-  PyEval_InitThreads();
-  #endif
-  #endif
-  /*--- Module creation code ---*/
-  #if PY_MAJOR_VERSION < 3
-  __pyx_m = Py_InitModule4(__Pyx_NAMESTR("csamtools"), __pyx_methods, 0, 0, PYTHON_API_VERSION);
-  #else
-  __pyx_m = PyModule_Create(&__pyx_moduledef);
-  #endif
-  if (!__pyx_m) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  #if PY_MAJOR_VERSION < 3
-  Py_INCREF(__pyx_m);
-  #endif
-  __pyx_b = PyImport_AddModule(__Pyx_NAMESTR(__Pyx_BUILTIN_MODULE_NAME));
-  if (!__pyx_b) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  if (__Pyx_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  /*--- Initialize various global constants etc. ---*/
-  if (unlikely(__Pyx_InitGlobals() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__pyx_module_is_main_csamtools) {
-    if (__Pyx_SetAttrString(__pyx_m, "__name__", __pyx_n_s____main__) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  }
-  /*--- Builtin init code ---*/
-  if (unlikely(__Pyx_InitCachedBuiltins() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  /*--- Global init code ---*/
-  /*--- Function export code ---*/
-  /*--- Type init code ---*/
-  __pyx_ptype_9csamtools_file = __Pyx_ImportType(__Pyx_BUILTIN_MODULE_NAME, "file", sizeof(PyFileObject), 0); if (unlikely(!__pyx_ptype_9csamtools_file)) {__pyx_filename = __pyx_f[1]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyType_Ready(&__pyx_type_9csamtools_AlignedRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_AlignedRead, "__str__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_11AlignedRead___str__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_11AlignedRead___str__.doc = __pyx_doc_9csamtools_11AlignedRead___str__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_11AlignedRead___str__;
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-  }
-  if (__Pyx_SetAttrString(__pyx_m, "AlignedRead", (PyObject *)&__pyx_type_9csamtools_AlignedRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_AlignedRead = &__pyx_type_9csamtools_AlignedRead;
-  __pyx_vtabptr_9csamtools_Samfile = &__pyx_vtable_9csamtools_Samfile;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_Samfile._buildHeader = (bam_header_t *(*)(struct __pyx_obj_9csamtools_Samfile *, PyObject *))__pyx_f_9csamtools_7Samfile__buildHeader;
-  __pyx_vtable_9csamtools_Samfile.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_Samfile *))__pyx_f_9csamtools_7Samfile_getCurrent;
-  __pyx_vtable_9csamtools_Samfile.cnext = (int (*)(struct __pyx_obj_9csamtools_Samfile *))__pyx_f_9csamtools_7Samfile_cnext;
-  __pyx_vtable_9csamtools_Samfile.write = (int (*)(struct __pyx_obj_9csamtools_Samfile *, struct __pyx_obj_9csamtools_AlignedRead *, int __pyx_skip_dispatch))__pyx_f_9csamtools_7Samfile_write;
-  __pyx_vtable_9csamtools_Samfile._getrname = (char *(*)(struct __pyx_obj_9csamtools_Samfile *, int))__pyx_f_9csamtools_7Samfile__getrname;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_Samfile._buildHeader = (void(*)(void))__pyx_f_9csamtools_7Samfile__buildHeader;
-  *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.getCurrent = (void(*)(void))__pyx_f_9csamtools_7Samfile_getCurrent;
-  *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.cnext = (void(*)(void))__pyx_f_9csamtools_7Samfile_cnext;
-  *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.write = (void(*)(void))__pyx_f_9csamtools_7Samfile_write;
-  *(void(**)(void))&__pyx_vtable_9csamtools_Samfile._getrname = (void(*)(void))__pyx_f_9csamtools_7Samfile__getrname;
-  #endif
-  if (PyType_Ready(&__pyx_type_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_Samfile, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_7Samfile___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_7Samfile___next__.doc = __pyx_doc_9csamtools_7Samfile___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_7Samfile___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_Samfile.tp_dict, __pyx_vtabptr_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "Samfile", (PyObject *)&__pyx_type_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_Samfile = &__pyx_type_9csamtools_Samfile;
-  if (PyType_Ready(&__pyx_type_9csamtools_PileupProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2601; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "PileupProxy", (PyObject *)&__pyx_type_9csamtools_PileupProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2601; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_PileupProxy = &__pyx_type_9csamtools_PileupProxy;
-  if (PyType_Ready(&__pyx_type_9csamtools_PileupRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2654; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "PileupRead", (PyObject *)&__pyx_type_9csamtools_PileupRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2654; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_PileupRead = &__pyx_type_9csamtools_PileupRead;
-  __pyx_vtabptr_9csamtools_Fastafile = &__pyx_vtable_9csamtools_Fastafile;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_Fastafile._fetch = (char *(*)(struct __pyx_obj_9csamtools_Fastafile *, char *, int, int, int *))__pyx_f_9csamtools_9Fastafile__fetch;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_Fastafile._fetch = (void(*)(void))__pyx_f_9csamtools_9Fastafile__fetch;
-  #endif
-  if (PyType_Ready(&__pyx_type_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_Fastafile.tp_dict, __pyx_vtabptr_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "Fastafile", (PyObject *)&__pyx_type_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_Fastafile = &__pyx_type_9csamtools_Fastafile;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorRow) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1187; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorRow", (PyObject *)&__pyx_type_9csamtools_IteratorRow) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1187; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorRow = &__pyx_type_9csamtools_IteratorRow;
-  __pyx_vtabptr_9csamtools_IteratorRowRegion = &__pyx_vtable_9csamtools_IteratorRowRegion;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_IteratorRowRegion.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowRegion *))__pyx_f_9csamtools_17IteratorRowRegion_getCurrent;
-  __pyx_vtable_9csamtools_IteratorRowRegion.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowRegion *))__pyx_f_9csamtools_17IteratorRowRegion_cnext;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowRegion.getCurrent = (void(*)(void))__pyx_f_9csamtools_17IteratorRowRegion_getCurrent;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowRegion.cnext = (void(*)(void))__pyx_f_9csamtools_17IteratorRowRegion_cnext;
-  #endif
-  __pyx_type_9csamtools_IteratorRowRegion.tp_base = __pyx_ptype_9csamtools_IteratorRow;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowRegion, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__.doc = __pyx_doc_9csamtools_17IteratorRowRegion___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowRegion.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorRowRegion", (PyObject *)&__pyx_type_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorRowRegion = &__pyx_type_9csamtools_IteratorRowRegion;
-  __pyx_vtabptr_9csamtools_IteratorRowAll = &__pyx_vtable_9csamtools_IteratorRowAll;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_IteratorRowAll.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowAll *))__pyx_f_9csamtools_14IteratorRowAll_getCurrent;
-  __pyx_vtable_9csamtools_IteratorRowAll.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowAll *))__pyx_f_9csamtools_14IteratorRowAll_cnext;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowAll.getCurrent = (void(*)(void))__pyx_f_9csamtools_14IteratorRowAll_getCurrent;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowAll.cnext = (void(*)(void))__pyx_f_9csamtools_14IteratorRowAll_cnext;
-  #endif
-  __pyx_type_9csamtools_IteratorRowAll.tp_base = __pyx_ptype_9csamtools_IteratorRow;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowAll, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_14IteratorRowAll___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_14IteratorRowAll___next__.doc = __pyx_doc_9csamtools_14IteratorRowAll___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_14IteratorRowAll___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowAll.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorRowAll", (PyObject *)&__pyx_type_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorRowAll = &__pyx_type_9csamtools_IteratorRowAll;
-  __pyx_type_9csamtools_IteratorRowAllRefs.tp_base = __pyx_ptype_9csamtools_IteratorRow;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowAllRefs, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__.doc = __pyx_doc_9csamtools_18IteratorRowAllRefs___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__;
-    }
-  }
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorRowAllRefs", (PyObject *)&__pyx_type_9csamtools_IteratorRowAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorRowAllRefs = &__pyx_type_9csamtools_IteratorRowAllRefs;
-  __pyx_vtabptr_9csamtools_IteratorRowSelection = &__pyx_vtable_9csamtools_IteratorRowSelection;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_IteratorRowSelection.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowSelection *))__pyx_f_9csamtools_20IteratorRowSelection_getCurrent;
-  __pyx_vtable_9csamtools_IteratorRowSelection.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowSelection *))__pyx_f_9csamtools_20IteratorRowSelection_cnext;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowSelection.getCurrent = (void(*)(void))__pyx_f_9csamtools_20IteratorRowSelection_getCurrent;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowSelection.cnext = (void(*)(void))__pyx_f_9csamtools_20IteratorRowSelection_cnext;
-  #endif
-  __pyx_type_9csamtools_IteratorRowSelection.tp_base = __pyx_ptype_9csamtools_IteratorRow;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowSelection, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__.doc = __pyx_doc_9csamtools_20IteratorRowSelection___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowSelection.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorRowSelection", (PyObject *)&__pyx_type_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorRowSelection = &__pyx_type_9csamtools_IteratorRowSelection;
-  __pyx_vtabptr_9csamtools_IteratorColumn = &__pyx_vtable_9csamtools_IteratorColumn;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_IteratorColumn.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorColumn *))__pyx_f_9csamtools_14IteratorColumn_cnext;
-  __pyx_vtable_9csamtools_IteratorColumn.getSequence = (char *(*)(struct __pyx_obj_9csamtools_IteratorColumn *))__pyx_f_9csamtools_14IteratorColumn_getSequence;
-  __pyx_vtable_9csamtools_IteratorColumn.setMask = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *))__pyx_f_9csamtools_14IteratorColumn_setMask;
-  __pyx_vtable_9csamtools_IteratorColumn.setupIteratorData = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, int, int, int, struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData *__pyx_optional_args))__pyx_f_9csamtools_14IteratorColumn_setupIteratorData;
-  __pyx_vtable_9csamtools_IteratorColumn.reset = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *, PyObject *, PyObject *))__pyx_f_9csamtools_14IteratorColumn_reset;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.cnext = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_cnext;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.getSequence = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_getSequence;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.setMask = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_setMask;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.setupIteratorData = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_setupIteratorData;
-  *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.reset = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_reset;
-  #endif
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumn.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorColumn", (PyObject *)&__pyx_type_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorColumn = &__pyx_type_9csamtools_IteratorColumn;
-  __pyx_vtabptr_9csamtools_IteratorColumnRegion = &__pyx_vtable_9csamtools_IteratorColumnRegion;
-  __pyx_vtable_9csamtools_IteratorColumnRegion.__pyx_base = *__pyx_vtabptr_9csamtools_IteratorColumn;
-  __pyx_type_9csamtools_IteratorColumnRegion.tp_base = __pyx_ptype_9csamtools_IteratorColumn;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorColumnRegion, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__.doc = __pyx_doc_9csamtools_20IteratorColumnRegion___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumnRegion.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorColumnRegion", (PyObject *)&__pyx_type_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorColumnRegion = &__pyx_type_9csamtools_IteratorColumnRegion;
-  __pyx_vtabptr_9csamtools_IteratorColumnAllRefs = &__pyx_vtable_9csamtools_IteratorColumnAllRefs;
-  __pyx_vtable_9csamtools_IteratorColumnAllRefs.__pyx_base = *__pyx_vtabptr_9csamtools_IteratorColumn;
-  __pyx_type_9csamtools_IteratorColumnAllRefs.tp_base = __pyx_ptype_9csamtools_IteratorColumn;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorColumnAllRefs, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__.doc = __pyx_doc_9csamtools_21IteratorColumnAllRefs___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__;
-    }
-  }
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumnAllRefs.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "IteratorColumnAllRefs", (PyObject *)&__pyx_type_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_IteratorColumnAllRefs = &__pyx_type_9csamtools_IteratorColumnAllRefs;
-  if (PyType_Ready(&__pyx_type_9csamtools_SNPCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2816; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "SNPCall", (PyObject *)&__pyx_type_9csamtools_SNPCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2816; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_SNPCall = &__pyx_type_9csamtools_SNPCall;
-  __pyx_vtabptr_9csamtools_SNPCallerBase = &__pyx_vtable_9csamtools_SNPCallerBase;
-  #if PY_MAJOR_VERSION >= 3
-  __pyx_vtable_9csamtools_SNPCallerBase.__dump = (PyObject *(*)(struct __pyx_obj_9csamtools_SNPCallerBase *, glf1_t *, uint32_t, int))__pyx_f_9csamtools_13SNPCallerBase___dump;
-  #else
-  *(void(**)(void))&__pyx_vtable_9csamtools_SNPCallerBase.__dump = (void(*)(void))__pyx_f_9csamtools_13SNPCallerBase___dump;
-  #endif
-  if (PyType_Ready(&__pyx_type_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetVtable(__pyx_type_9csamtools_SNPCallerBase.tp_dict, __pyx_vtabptr_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "SNPCallerBase", (PyObject *)&__pyx_type_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_9csamtools_SNPCallerBase = &__pyx_type_9csamtools_SNPCallerBase;
-  __pyx_vtabptr_9csamtools_IteratorSNPCalls = &__pyx_vtable_9csamtools_IteratorSNPCalls;
-  __pyx_vtable_9csamtools_IteratorSNPCalls.__pyx_base = *__pyx_vtabptr_9csamtools_SNPCallerBase;
-  __pyx_type_9csamtools_IteratorSNPCalls.tp_base = __pyx_ptype_9csamtools_SNPCallerBase;
-  if (PyType_Ready(&__pyx_type_9csamtools_IteratorSNPCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorSNPCalls, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
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-  if (__Pyx_SetAttrString(__pyx_m, "IteratorSNPCalls", (PyObject *)&__pyx_type_9csamtools_IteratorSNPCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  if (__Pyx_SetVtable(__pyx_type_9csamtools_SNPCaller.tp_dict, __pyx_vtabptr_9csamtools_SNPCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3021; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "SNPCaller", (PyObject *)&__pyx_type_9csamtools_SNPCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3021; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  if (__Pyx_SetAttrString(__pyx_m, "IndelCall", (PyObject *)&__pyx_type_9csamtools_IndelCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3103; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  if (__Pyx_SetAttrString(__pyx_m, "IndelCallerBase", (PyObject *)&__pyx_type_9csamtools_IndelCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3192; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorIndelCalls, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3330; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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- * import ctypes             # <<<<<<<<<<<<<<
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-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":13
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-  if (__pyx_t_5) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":209
- * 
- * if platform.system()=='Windows':
- *     del StderrStore             # <<<<<<<<<<<<<<
- *     StderrStore = StderrStoreWindows
- * 
- */
-    if (__Pyx_DelAttrString(__pyx_m, "StderrStore") < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 209; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-    /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":210
- * if platform.system()=='Windows':
- *     del StderrStore
- *     StderrStore = StderrStoreWindows             # <<<<<<<<<<<<<<
- * 
- * 
- */
-    __pyx_t_3 = __Pyx_GetName(__pyx_m, __pyx_n_s__StderrStoreWindows); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 210; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_3);
-    if (PyObject_SetAttr(__pyx_m, __pyx_n_s__StderrStore, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 210; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-    goto __pyx_L2;
-  }
-  __pyx_L2:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":217
- * ######################################################################
- * # valid types for sam headers
- * VALID_HEADER_TYPES = { "HD" : dict,             # <<<<<<<<<<<<<<
- *                        "SQ" : list,
- *                        "RG" : list,
- */
-  __pyx_t_3 = PyDict_New(); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__HD), ((PyObject *)((PyObject*)&PyDict_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":218
- * # valid types for sam headers
- * VALID_HEADER_TYPES = { "HD" : dict,
- *                        "SQ" : list,             # <<<<<<<<<<<<<<
- *                        "RG" : list,
- *                        "PG" : list,
- */
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__SQ), ((PyObject *)((PyObject*)&PyList_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":219
- * VALID_HEADER_TYPES = { "HD" : dict,
- *                        "SQ" : list,
- *                        "RG" : list,             # <<<<<<<<<<<<<<
- *                        "PG" : list,
- *                        "CO" : list }
- */
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__RG), ((PyObject *)((PyObject*)&PyList_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":220
- *                        "SQ" : list,
- *                        "RG" : list,
- *                        "PG" : list,             # <<<<<<<<<<<<<<
- *                        "CO" : list }
- * 
- */
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__PG), ((PyObject *)((PyObject*)&PyList_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":221
- *                        "RG" : list,
- *                        "PG" : list,
- *                        "CO" : list }             # <<<<<<<<<<<<<<
- * 
- * # order of records within sam headers
- */
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__CO), ((PyObject *)((PyObject*)&PyList_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyObject_SetAttr(__pyx_m, __pyx_n_s__VALID_HEADER_TYPES, ((PyObject *)__pyx_t_3)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 217; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":224
- * 
- * # order of records within sam headers
- * VALID_HEADERS = ("HD", "SQ", "RG", "PG", "CO" )             # <<<<<<<<<<<<<<
- * 
- * # type conversions within sam header records
- */
-  __pyx_t_3 = PyTuple_New(5); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 224; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __Pyx_INCREF(((PyObject *)__pyx_n_s__HD));
-  PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_n_s__HD));
-  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__HD));
-  __Pyx_INCREF(((PyObject *)__pyx_n_s__SQ));
-  PyTuple_SET_ITEM(__pyx_t_3, 1, ((PyObject *)__pyx_n_s__SQ));
-  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__SQ));
-  __Pyx_INCREF(((PyObject *)__pyx_n_s__RG));
-  PyTuple_SET_ITEM(__pyx_t_3, 2, ((PyObject *)__pyx_n_s__RG));
-  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__RG));
-  __Pyx_INCREF(((PyObject *)__pyx_n_s__PG));
-  PyTuple_SET_ITEM(__pyx_t_3, 3, ((PyObject *)__pyx_n_s__PG));
-  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__PG));
-  __Pyx_INCREF(((PyObject *)__pyx_n_s__CO));
-  PyTuple_SET_ITEM(__pyx_t_3, 4, ((PyObject *)__pyx_n_s__CO));
-  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__CO));
-  if (PyObject_SetAttr(__pyx_m, __pyx_n_s__VALID_HEADERS, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 224; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":227
- * 
- * # type conversions within sam header records
- * VALID_HEADER_FIELDS = { "HD" : { "VN" : str, "SO" : str, "GO" : str },             # <<<<<<<<<<<<<<
- *                         "SQ" : { "SN" : str, "LN" : int, "AS" : str, "M5" : str, "UR" : str, "SP" : str },
- *                         "RG" : { "ID" : str, "SM" : str, "LB" : str, "DS" : str, "PU" : str, "PI" : str, "CN" : str, "DT" : str, "PL" : str, },
- */
-  __pyx_t_3 = PyDict_New(); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
-  __pyx_t_1 = PyDict_New(); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__VN), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__SO), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__GO), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__HD), ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":228
- * # type conversions within sam header records
- * VALID_HEADER_FIELDS = { "HD" : { "VN" : str, "SO" : str, "GO" : str },
- *                         "SQ" : { "SN" : str, "LN" : int, "AS" : str, "M5" : str, "UR" : str, "SP" : str },             # <<<<<<<<<<<<<<
- *                         "RG" : { "ID" : str, "SM" : str, "LB" : str, "DS" : str, "PU" : str, "PI" : str, "CN" : str, "DT" : str, "PL" : str, },
- *                         "PG" : { "PN" : str, "ID" : str, "VN" : str, "CL" : str }, }
- */
-  __pyx_t_1 = PyDict_New(); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__SN), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__LN), ((PyObject *)((PyObject*)&PyInt_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__AS), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__M5), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__UR), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__SP), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 228; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__SQ), ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":229
- * VALID_HEADER_FIELDS = { "HD" : { "VN" : str, "SO" : str, "GO" : str },
- *                         "SQ" : { "SN" : str, "LN" : int, "AS" : str, "M5" : str, "UR" : str, "SP" : str },
- *                         "RG" : { "ID" : str, "SM" : str, "LB" : str, "DS" : str, "PU" : str, "PI" : str, "CN" : str, "DT" : str, "PL" : str, },             # <<<<<<<<<<<<<<
- *                         "PG" : { "PN" : str, "ID" : str, "VN" : str, "CL" : str }, }
- * 
- */
-  __pyx_t_1 = PyDict_New(); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__ID), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__SM), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__LB), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__DS), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__PU), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__PI), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__CN), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__DT), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__PL), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 229; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__RG), ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
-
-  /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":230
- *                         "SQ" : { "SN" : str, "LN" : int, "AS" : str, "M5" : str, "UR" : str, "SP" : str },
- *                         "RG" : { "ID" : str, "SM" : str, "LB" : str, "DS" : str, "PU" : str, "PI" : str, "CN" : str, "DT" : str, "PL" : str, },
- *                         "PG" : { "PN" : str, "ID" : str, "VN" : str, "CL" : str }, }             # <<<<<<<<<<<<<<
- * 
- * # output order of fields within records
- */
-  __pyx_t_1 = PyDict_New(); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 230; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__PN), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 230; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__ID), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 230; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__VN), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 230; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_n_s__CL), ((PyObject *)((PyObject*)&PyString_Type))) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 230; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (PyDict_SetItem(__pyx_t_3, ((PyObject *)__pyx_n_s__PG), ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 227; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
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-  /* "/ifs/apps/apps/python-2.7.1/lib/python2.7/site-packages/Cython-0.13-py2.7-linux-x86_64.egg/Cython/Includes/cpython/type.pxd":2
- * 
- * cdef extern from "Python.h":             # <<<<<<<<<<<<<<
- *     # The C structure of the objects used to describe built-in types.
- * 
- */
-  goto __pyx_L0;
-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_1);
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-    __Pyx_AddTraceback("init csamtools");
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-    PyObject *result;
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-    if (!result)
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-static int __Pyx_TraceSetupAndCall(PyCodeObject** code,
-                                   PyFrameObject** frame,
-                                   const char *funcname,
-                                   const char *srcfile,
-                                   int firstlineno) {
-    if (*frame == NULL || !CYTHON_PROFILE_REUSE_FRAME) {
-        if (*code == NULL) {
-            *code = __Pyx_createFrameCodeObject(funcname, srcfile, firstlineno);
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-    else {
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-    }
-    return PyThreadState_GET()->c_profilefunc(PyThreadState_GET()->c_profileobj, *frame, PyTrace_CALL, NULL) == 0;
-}
-
-static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno) {
-    PyObject *py_srcfile = 0;
-    PyObject *py_funcname = 0;
-    PyCodeObject *py_code = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_funcname = PyString_FromString(funcname);
-    py_srcfile = PyString_FromString(srcfile);
-    #else
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-    py_srcfile = PyUnicode_FromString(srcfile);
-    #endif
-    if (!py_funcname | !py_srcfile) goto bad;
-
-    py_code = PyCode_New(
-        0,                /*int argcount,*/
-        #if PY_MAJOR_VERSION >= 3
-        0,                /*int kwonlyargcount,*/
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-        0,                /*int nlocals,*/
-        0,                /*int stacksize,*/
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-        __pyx_empty_bytes,  /*PyObject *code,*/
-        __pyx_empty_tuple,  /*PyObject *consts,*/
-        __pyx_empty_tuple,  /*PyObject *names,*/
-        __pyx_empty_tuple,  /*PyObject *varnames,*/
-        __pyx_empty_tuple,  /*PyObject *freevars,*/
-        __pyx_empty_tuple,  /*PyObject *cellvars,*/
-        py_srcfile,       /*PyObject *filename,*/
-        py_funcname,      /*PyObject *name,*/
-        firstlineno,      /*int firstlineno,*/
-        __pyx_empty_bytes   /*PyObject *lnotab*/
-    );
-
-bad: 
-    Py_XDECREF(py_srcfile);
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-    
-    return py_code;
-}
-
-#endif /* CYTHON_PROFILE */
-
-static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type) {
-    if (unlikely(!type)) {
-        PyErr_Format(PyExc_SystemError, "Missing type object");
-        return 0;
-    }
-    if (likely(PyObject_TypeCheck(obj, type)))
-        return 1;
-    PyErr_Format(PyExc_TypeError, "Cannot convert %.200s to %.200s",
-                 Py_TYPE(obj)->tp_name, type->tp_name);
-    return 0;
-}
-
-static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
-    PyErr_Format(PyExc_ValueError,
-        #if PY_VERSION_HEX < 0x02050000
-                 "need more than %d value%s to unpack", (int)index,
-        #else
-                 "need more than %zd value%s to unpack", index,
-        #endif
-                 (index == 1) ? "" : "s");
-}
-
-static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
-    PyErr_Format(PyExc_ValueError,
-        #if PY_VERSION_HEX < 0x02050000
-            "too many values to unpack (expected %d)", (int)expected);
-        #else
-            "too many values to unpack (expected %zd)", expected);
-        #endif
-}
-
-static PyObject *__Pyx_UnpackItem(PyObject *iter, Py_ssize_t index) {
-    PyObject *item;
-    if (!(item = PyIter_Next(iter))) {
-        if (!PyErr_Occurred()) {
-            __Pyx_RaiseNeedMoreValuesError(index);
-        }
-    }
-    return item;
-}
-
-static int __Pyx_EndUnpack(PyObject *iter, Py_ssize_t expected) {
-    PyObject *item;
-    if ((item = PyIter_Next(iter))) {
-        Py_DECREF(item);
-        __Pyx_RaiseTooManyValuesError(expected);
-        return -1;
-    }
-    else if (!PyErr_Occurred())
-        return 0;
-    else
-        return -1;
-}
-
-static CYTHON_INLINE int __Pyx_CheckKeywordStrings(
-    PyObject *kwdict,
-    const char* function_name,
-    int kw_allowed)
-{
-    PyObject* key = 0;
-    Py_ssize_t pos = 0;
-    while (PyDict_Next(kwdict, &pos, &key, 0)) {
-        #if PY_MAJOR_VERSION < 3
-        if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key)))
-        #else
-        if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key)))
-        #endif
-            goto invalid_keyword_type;
-    }
-    if ((!kw_allowed) && unlikely(key))
-        goto invalid_keyword;
-    return 1;
-invalid_keyword_type:
-    PyErr_Format(PyExc_TypeError,
-        "%s() keywords must be strings", function_name);
-    return 0;
-invalid_keyword:
-    PyErr_Format(PyExc_TypeError,
-    #if PY_MAJOR_VERSION < 3
-        "%s() got an unexpected keyword argument '%s'",
-        function_name, PyString_AsString(key));
-    #else
-        "%s() got an unexpected keyword argument '%U'",
-        function_name, key);
-    #endif
-    return 0;
-}
-
-static void __Pyx_RaiseDoubleKeywordsError(
-    const char* func_name,
-    PyObject* kw_name)
-{
-    PyErr_Format(PyExc_TypeError,
-        #if PY_MAJOR_VERSION >= 3
-        "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
-        #else
-        "%s() got multiple values for keyword argument '%s'", func_name,
-        PyString_AS_STRING(kw_name));
-        #endif
-}
-
-static void __Pyx_RaiseArgtupleInvalid(
-    const char* func_name,
-    int exact,
-    Py_ssize_t num_min,
-    Py_ssize_t num_max,
-    Py_ssize_t num_found)
-{
-    Py_ssize_t num_expected;
-    const char *number, *more_or_less;
-
-    if (num_found < num_min) {
-        num_expected = num_min;
-        more_or_less = "at least";
-    } else {
-        num_expected = num_max;
-        more_or_less = "at most";
-    }
-    if (exact) {
-        more_or_less = "exactly";
-    }
-    number = (num_expected == 1) ? "" : "s";
-    PyErr_Format(PyExc_TypeError,
-        #if PY_VERSION_HEX < 0x02050000
-            "%s() takes %s %d positional argument%s (%d given)",
-        #else
-            "%s() takes %s %zd positional argument%s (%zd given)",
-        #endif
-        func_name, more_or_less, num_expected, number, num_found);
-}
-
-static int __Pyx_ParseOptionalKeywords(
-    PyObject *kwds,
-    PyObject **argnames[],
-    PyObject *kwds2,
-    PyObject *values[],
-    Py_ssize_t num_pos_args,
-    const char* function_name)
-{
-    PyObject *key = 0, *value = 0;
-    Py_ssize_t pos = 0;
-    PyObject*** name;
-    PyObject*** first_kw_arg = argnames + num_pos_args;
-
-    while (PyDict_Next(kwds, &pos, &key, &value)) {
-        name = first_kw_arg;
-        while (*name && (**name != key)) name++;
-        if (*name) {
-            values[name-argnames] = value;
-        } else {
-            #if PY_MAJOR_VERSION < 3
-            if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key))) {
-            #else
-            if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key))) {
-            #endif
-                goto invalid_keyword_type;
-            } else {
-                for (name = first_kw_arg; *name; name++) {
-                    #if PY_MAJOR_VERSION >= 3
-                    if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
-                        PyUnicode_Compare(**name, key) == 0) break;
-                    #else
-                    if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
-                        _PyString_Eq(**name, key)) break;
-                    #endif
-                }
-                if (*name) {
-                    values[name-argnames] = value;
-                } else {
-                    /* unexpected keyword found */
-                    for (name=argnames; name != first_kw_arg; name++) {
-                        if (**name == key) goto arg_passed_twice;
-                        #if PY_MAJOR_VERSION >= 3
-                        if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
-                            PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
-                        #else
-                        if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
-                            _PyString_Eq(**name, key)) goto arg_passed_twice;
-                        #endif
-                    }
-                    if (kwds2) {
-                        if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
-                    } else {
-                        goto invalid_keyword;
-                    }
-                }
-            }
-        }
-    }
-    return 0;
-arg_passed_twice:
-    __Pyx_RaiseDoubleKeywordsError(function_name, **name);
-    goto bad;
-invalid_keyword_type:
-    PyErr_Format(PyExc_TypeError,
-        "%s() keywords must be strings", function_name);
-    goto bad;
-invalid_keyword:
-    PyErr_Format(PyExc_TypeError,
-    #if PY_MAJOR_VERSION < 3
-        "%s() got an unexpected keyword argument '%s'",
-        function_name, PyString_AsString(key));
-    #else
-        "%s() got an unexpected keyword argument '%U'",
-        function_name, key);
-    #endif
-bad:
-    return -1;
-}
-
-static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-
-    tmp_type = tstate->curexc_type;
-    tmp_value = tstate->curexc_value;
-    tmp_tb = tstate->curexc_traceback;
-    tstate->curexc_type = type;
-    tstate->curexc_value = value;
-    tstate->curexc_traceback = tb;
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-}
-
-static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
-    PyThreadState *tstate = PyThreadState_GET();
-    *type = tstate->curexc_type;
-    *value = tstate->curexc_value;
-    *tb = tstate->curexc_traceback;
-
-    tstate->curexc_type = 0;
-    tstate->curexc_value = 0;
-    tstate->curexc_traceback = 0;
-}
-
-
-static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
-    const char *name, int exact)
-{
-    if (!type) {
-        PyErr_Format(PyExc_SystemError, "Missing type object");
-        return 0;
-    }
-    if (none_allowed && obj == Py_None) return 1;
-    else if (exact) {
-        if (Py_TYPE(obj) == type) return 1;
-    }
-    else {
-        if (PyObject_TypeCheck(obj, type)) return 1;
-    }
-    PyErr_Format(PyExc_TypeError,
-        "Argument '%s' has incorrect type (expected %s, got %s)",
-        name, type->tp_name, Py_TYPE(obj)->tp_name);
-    return 0;
-}
-
-static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb) {
-    PyObject *local_type, *local_value, *local_tb;
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-    local_type = tstate->curexc_type;
-    local_value = tstate->curexc_value;
-    local_tb = tstate->curexc_traceback;
-    tstate->curexc_type = 0;
-    tstate->curexc_value = 0;
-    tstate->curexc_traceback = 0;
-    PyErr_NormalizeException(&local_type, &local_value, &local_tb);
-    if (unlikely(tstate->curexc_type))
-        goto bad;
-    #if PY_MAJOR_VERSION >= 3
-    if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
-        goto bad;
-    #endif
-    *type = local_type;
-    *value = local_value;
-    *tb = local_tb;
-    Py_INCREF(local_type);
-    Py_INCREF(local_value);
-    Py_INCREF(local_tb);
-    tmp_type = tstate->exc_type;
-    tmp_value = tstate->exc_value;
-    tmp_tb = tstate->exc_traceback;
-    tstate->exc_type = local_type;
-    tstate->exc_value = local_value;
-    tstate->exc_traceback = local_tb;
-    /* Make sure tstate is in a consistent state when we XDECREF
-       these objects (XDECREF may run arbitrary code). */
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-    return 0;
-bad:
-    *type = 0;
-    *value = 0;
-    *tb = 0;
-    Py_XDECREF(local_type);
-    Py_XDECREF(local_value);
-    Py_XDECREF(local_tb);
-    return -1;
-}
-
-
-
-static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void) {
-    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
-}
-
-static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
-    PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
-}
-
-static CYTHON_INLINE long __Pyx_div_long(long a, long b) {
-    long q = a / b;
-    long r = a - q*b;
-    q -= ((r != 0) & ((r ^ b) < 0));
-    return q;
-}
-
-static CYTHON_INLINE long __Pyx_mod_long(long a, long b) {
-    long r = a % b;
-    r += ((r != 0) & ((r ^ b) < 0)) * b;
-    return r;
-}
-
-
-static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
-    PyThreadState *tstate = PyThreadState_GET();
-    *type = tstate->exc_type;
-    *value = tstate->exc_value;
-    *tb = tstate->exc_traceback;
-    Py_XINCREF(*type);
-    Py_XINCREF(*value);
-    Py_XINCREF(*tb);
-}
-
-static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-    tmp_type = tstate->exc_type;
-    tmp_value = tstate->exc_value;
-    tmp_tb = tstate->exc_traceback;
-    tstate->exc_type = type;
-    tstate->exc_value = value;
-    tstate->exc_traceback = tb;
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-}
-
-static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
-    PyObject *py_import = 0;
-    PyObject *empty_list = 0;
-    PyObject *module = 0;
-    PyObject *global_dict = 0;
-    PyObject *empty_dict = 0;
-    PyObject *list;
-    py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
-    if (!py_import)
-        goto bad;
-    if (from_list)
-        list = from_list;
-    else {
-        empty_list = PyList_New(0);
-        if (!empty_list)
-            goto bad;
-        list = empty_list;
-    }
-    global_dict = PyModule_GetDict(__pyx_m);
-    if (!global_dict)
-        goto bad;
-    empty_dict = PyDict_New();
-    if (!empty_dict)
-        goto bad;
-    module = PyObject_CallFunctionObjArgs(py_import,
-        name, global_dict, empty_dict, list, NULL);
-bad:
-    Py_XDECREF(empty_list);
-    Py_XDECREF(py_import);
-    Py_XDECREF(empty_dict);
-    return module;
-}
-
-static PyObject *__Pyx_CreateClass(
-    PyObject *bases, PyObject *dict, PyObject *name, const char *modname)
-{
-    PyObject *py_modname;
-    PyObject *result = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_modname = PyString_FromString(modname);
-    #else
-    py_modname = PyUnicode_FromString(modname);
-    #endif
-    if (!py_modname)
-        goto bad;
-    if (PyDict_SetItemString(dict, "__module__", py_modname) < 0)
-        goto bad;
-    #if PY_MAJOR_VERSION < 3
-    result = PyClass_New(bases, dict, name);
-    #else
-    result = PyObject_CallFunctionObjArgs((PyObject *)&PyType_Type, name, bases, dict, NULL);
-    #endif
-bad:
-    Py_XDECREF(py_modname);
-    return result;
-}
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t val) {
-    const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if ((sizeof(uint32_t) == sizeof(char))  ||
-        (sizeof(uint32_t) == sizeof(short))) {
-        return PyInt_FromLong((long)val);
-    } else if ((sizeof(uint32_t) == sizeof(int)) ||
-               (sizeof(uint32_t) == sizeof(long))) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLong((unsigned long)val);
-        else
-            return PyInt_FromLong((long)val);
-    } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
-        else
-            return PyLong_FromLongLong((PY_LONG_LONG)val);
-    } else {
-        int one = 1; int little = (int)*(unsigned char *)&one;
-        unsigned char *bytes = (unsigned char *)&val;
-        return _PyLong_FromByteArray(bytes, sizeof(uint32_t), 
-                                     little, !is_unsigned);
-    }
-}
-
-#if PY_MAJOR_VERSION < 3
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
-    Py_XINCREF(type);
-    Py_XINCREF(value);
-    Py_XINCREF(tb);
-    /* First, check the traceback argument, replacing None with NULL. */
-    if (tb == Py_None) {
-        Py_DECREF(tb);
-        tb = 0;
-    }
-    else if (tb != NULL && !PyTraceBack_Check(tb)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: arg 3 must be a traceback or None");
-        goto raise_error;
-    }
-    /* Next, replace a missing value with None */
-    if (value == NULL) {
-        value = Py_None;
-        Py_INCREF(value);
-    }
-    #if PY_VERSION_HEX < 0x02050000
-    if (!PyClass_Check(type))
-    #else
-    if (!PyType_Check(type))
-    #endif
-    {
-        /* Raising an instance.  The value should be a dummy. */
-        if (value != Py_None) {
-            PyErr_SetString(PyExc_TypeError,
-                "instance exception may not have a separate value");
-            goto raise_error;
-        }
-        /* Normalize to raise <class>, <instance> */
-        Py_DECREF(value);
-        value = type;
-        #if PY_VERSION_HEX < 0x02050000
-            if (PyInstance_Check(type)) {
-                type = (PyObject*) ((PyInstanceObject*)type)->in_class;
-                Py_INCREF(type);
-            }
-            else {
-                type = 0;
-                PyErr_SetString(PyExc_TypeError,
-                    "raise: exception must be an old-style class or instance");
-                goto raise_error;
-            }
-        #else
-            type = (PyObject*) Py_TYPE(type);
-            Py_INCREF(type);
-            if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
-                PyErr_SetString(PyExc_TypeError,
-                    "raise: exception class must be a subclass of BaseException");
-                goto raise_error;
-            }
-        #endif
-    }
-
-    __Pyx_ErrRestore(type, value, tb);
-    return;
-raise_error:
-    Py_XDECREF(value);
-    Py_XDECREF(type);
-    Py_XDECREF(tb);
-    return;
-}
-
-#else /* Python 3+ */
-
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
-    if (tb == Py_None) {
-        tb = 0;
-    } else if (tb && !PyTraceBack_Check(tb)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: arg 3 must be a traceback or None");
-        goto bad;
-    }
-    if (value == Py_None)
-        value = 0;
-
-    if (PyExceptionInstance_Check(type)) {
-        if (value) {
-            PyErr_SetString(PyExc_TypeError,
-                "instance exception may not have a separate value");
-            goto bad;
-        }
-        value = type;
-        type = (PyObject*) Py_TYPE(value);
-    } else if (!PyExceptionClass_Check(type)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: exception class must be a subclass of BaseException");
-        goto bad;
-    }
-
-    PyErr_SetObject(type, value);
-
-    if (tb) {
-        PyThreadState *tstate = PyThreadState_GET();
-        PyObject* tmp_tb = tstate->curexc_traceback;
-        if (tb != tmp_tb) {
-            Py_INCREF(tb);
-            tstate->curexc_traceback = tb;
-            Py_XDECREF(tmp_tb);
-        }
-    }
-
-bad:
-    return;
-}
-#endif
-
-static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject* x) {
-    const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if (sizeof(uint32_t) == sizeof(char)) {
-        if (is_unsigned)
-            return (uint32_t)__Pyx_PyInt_AsUnsignedChar(x);
-        else
-            return (uint32_t)__Pyx_PyInt_AsSignedChar(x);
-    } else if (sizeof(uint32_t) == sizeof(short)) {
-        if (is_unsigned)
-            return (uint32_t)__Pyx_PyInt_AsUnsignedShort(x);
-        else
-            return (uint32_t)__Pyx_PyInt_AsSignedShort(x);
-    } else if (sizeof(uint32_t) == sizeof(int)) {
-        if (is_unsigned)
-            return (uint32_t)__Pyx_PyInt_AsUnsignedInt(x);
-        else
-            return (uint32_t)__Pyx_PyInt_AsSignedInt(x);
-    } else if (sizeof(uint32_t) == sizeof(long)) {
-        if (is_unsigned)
-            return (uint32_t)__Pyx_PyInt_AsUnsignedLong(x);
-        else
-            return (uint32_t)__Pyx_PyInt_AsSignedLong(x);
-    } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return (uint32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
-        else
-            return (uint32_t)__Pyx_PyInt_AsSignedLongLong(x);
-    }  else {
-        uint32_t val;
-        PyObject *v = __Pyx_PyNumber_Int(x);
-        #if PY_VERSION_HEX < 0x03000000
-        if (likely(v) && !PyLong_Check(v)) {
-            PyObject *tmp = v;
-            v = PyNumber_Long(tmp);
-            Py_DECREF(tmp);
-        }
-        #endif
-        if (likely(v)) {
-            int one = 1; int is_little = (int)*(unsigned char *)&one;
-            unsigned char *bytes = (unsigned char *)&val;
-            int ret = _PyLong_AsByteArray((PyLongObject *)v,
-                                          bytes, sizeof(val),
-                                          is_little, !is_unsigned);
-            Py_DECREF(v);
-            if (likely(!ret))
-                return val;
-        }
-        return (uint32_t)-1;
-    }
-}
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int32_t(int32_t val) {
-    const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if ((sizeof(int32_t) == sizeof(char))  ||
-        (sizeof(int32_t) == sizeof(short))) {
-        return PyInt_FromLong((long)val);
-    } else if ((sizeof(int32_t) == sizeof(int)) ||
-               (sizeof(int32_t) == sizeof(long))) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLong((unsigned long)val);
-        else
-            return PyInt_FromLong((long)val);
-    } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
-        else
-            return PyLong_FromLongLong((PY_LONG_LONG)val);
-    } else {
-        int one = 1; int little = (int)*(unsigned char *)&one;
-        unsigned char *bytes = (unsigned char *)&val;
-        return _PyLong_FromByteArray(bytes, sizeof(int32_t), 
-                                     little, !is_unsigned);
-    }
-}
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int64_t(int64_t val) {
-    const int64_t neg_one = (int64_t)-1, const_zero = (int64_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if ((sizeof(int64_t) == sizeof(char))  ||
-        (sizeof(int64_t) == sizeof(short))) {
-        return PyInt_FromLong((long)val);
-    } else if ((sizeof(int64_t) == sizeof(int)) ||
-               (sizeof(int64_t) == sizeof(long))) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLong((unsigned long)val);
-        else
-            return PyInt_FromLong((long)val);
-    } else if (sizeof(int64_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
-        else
-            return PyLong_FromLongLong((PY_LONG_LONG)val);
-    } else {
-        int one = 1; int little = (int)*(unsigned char *)&one;
-        unsigned char *bytes = (unsigned char *)&val;
-        return _PyLong_FromByteArray(bytes, sizeof(int64_t), 
-                                     little, !is_unsigned);
-    }
-}
-
-static CYTHON_INLINE uint64_t __Pyx_PyInt_from_py_uint64_t(PyObject* x) {
-    const uint64_t neg_one = (uint64_t)-1, const_zero = (uint64_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if (sizeof(uint64_t) == sizeof(char)) {
-        if (is_unsigned)
-            return (uint64_t)__Pyx_PyInt_AsUnsignedChar(x);
-        else
-            return (uint64_t)__Pyx_PyInt_AsSignedChar(x);
-    } else if (sizeof(uint64_t) == sizeof(short)) {
-        if (is_unsigned)
-            return (uint64_t)__Pyx_PyInt_AsUnsignedShort(x);
-        else
-            return (uint64_t)__Pyx_PyInt_AsSignedShort(x);
-    } else if (sizeof(uint64_t) == sizeof(int)) {
-        if (is_unsigned)
-            return (uint64_t)__Pyx_PyInt_AsUnsignedInt(x);
-        else
-            return (uint64_t)__Pyx_PyInt_AsSignedInt(x);
-    } else if (sizeof(uint64_t) == sizeof(long)) {
-        if (is_unsigned)
-            return (uint64_t)__Pyx_PyInt_AsUnsignedLong(x);
-        else
-            return (uint64_t)__Pyx_PyInt_AsSignedLong(x);
-    } else if (sizeof(uint64_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return (uint64_t)__Pyx_PyInt_AsUnsignedLongLong(x);
-        else
-            return (uint64_t)__Pyx_PyInt_AsSignedLongLong(x);
-    }  else {
-        uint64_t val;
-        PyObject *v = __Pyx_PyNumber_Int(x);
-        #if PY_VERSION_HEX < 0x03000000
-        if (likely(v) && !PyLong_Check(v)) {
-            PyObject *tmp = v;
-            v = PyNumber_Long(tmp);
-            Py_DECREF(tmp);
-        }
-        #endif
-        if (likely(v)) {
-            int one = 1; int is_little = (int)*(unsigned char *)&one;
-            unsigned char *bytes = (unsigned char *)&val;
-            int ret = _PyLong_AsByteArray((PyLongObject *)v,
-                                          bytes, sizeof(val),
-                                          is_little, !is_unsigned);
-            Py_DECREF(v);
-            if (likely(!ret))
-                return val;
-        }
-        return (uint64_t)-1;
-    }
-}
-
-static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject* x) {
-    const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if (sizeof(int32_t) == sizeof(char)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedChar(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedChar(x);
-    } else if (sizeof(int32_t) == sizeof(short)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedShort(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedShort(x);
-    } else if (sizeof(int32_t) == sizeof(int)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedInt(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedInt(x);
-    } else if (sizeof(int32_t) == sizeof(long)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedLong(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedLong(x);
-    } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedLongLong(x);
-    }  else {
-        int32_t val;
-        PyObject *v = __Pyx_PyNumber_Int(x);
-        #if PY_VERSION_HEX < 0x03000000
-        if (likely(v) && !PyLong_Check(v)) {
-            PyObject *tmp = v;
-            v = PyNumber_Long(tmp);
-            Py_DECREF(tmp);
-        }
-        #endif
-        if (likely(v)) {
-            int one = 1; int is_little = (int)*(unsigned char *)&one;
-            unsigned char *bytes = (unsigned char *)&val;
-            int ret = _PyLong_AsByteArray((PyLongObject *)v,
-                                          bytes, sizeof(val),
-                                          is_little, !is_unsigned);
-            Py_DECREF(v);
-            if (likely(!ret))
-                return val;
-        }
-        return (int32_t)-1;
-    }
-}
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint8_t(uint8_t val) {
-    const uint8_t neg_one = (uint8_t)-1, const_zero = (uint8_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if ((sizeof(uint8_t) == sizeof(char))  ||
-        (sizeof(uint8_t) == sizeof(short))) {
-        return PyInt_FromLong((long)val);
-    } else if ((sizeof(uint8_t) == sizeof(int)) ||
-               (sizeof(uint8_t) == sizeof(long))) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLong((unsigned long)val);
-        else
-            return PyInt_FromLong((long)val);
-    } else if (sizeof(uint8_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
-        else
-            return PyLong_FromLongLong((PY_LONG_LONG)val);
-    } else {
-        int one = 1; int little = (int)*(unsigned char *)&one;
-        unsigned char *bytes = (unsigned char *)&val;
-        return _PyLong_FromByteArray(bytes, sizeof(uint8_t), 
-                                     little, !is_unsigned);
-    }
-}
-
-#if PY_MAJOR_VERSION < 3
-static PyObject *__Pyx_GetStdout(void) {
-    PyObject *f = PySys_GetObject((char *)"stdout");
-    if (!f) {
-        PyErr_SetString(PyExc_RuntimeError, "lost sys.stdout");
-    }
-    return f;
-}
-
-static int __Pyx_Print(PyObject* f, PyObject *arg_tuple, int newline) {
-    PyObject* v;
-    int i;
-
-    if (!f) {
-        if (!(f = __Pyx_GetStdout()))
-            return -1;
-    }
-    for (i=0; i < PyTuple_GET_SIZE(arg_tuple); i++) {
-        if (PyFile_SoftSpace(f, 1)) {
-            if (PyFile_WriteString(" ", f) < 0)
-                return -1;
-        }
-        v = PyTuple_GET_ITEM(arg_tuple, i);
-        if (PyFile_WriteObject(v, f, Py_PRINT_RAW) < 0)
-            return -1;
-        if (PyString_Check(v)) {
-            char *s = PyString_AsString(v);
-            Py_ssize_t len = PyString_Size(v);
-            if (len > 0 &&
-                isspace(Py_CHARMASK(s[len-1])) &&
-                s[len-1] != ' ')
-                    PyFile_SoftSpace(f, 0);
-        }
-    }
-    if (newline) {
-        if (PyFile_WriteString("\n", f) < 0)
-            return -1;
-        PyFile_SoftSpace(f, 0);
-    }
-    return 0;
-}
-
-#else /* Python 3 has a print function */
-
-static int __Pyx_Print(PyObject* stream, PyObject *arg_tuple, int newline) {
-    PyObject* kwargs = 0;
-    PyObject* result = 0;
-    PyObject* end_string;
-    if (unlikely(!__pyx_print)) {
-        __pyx_print = __Pyx_GetAttrString(__pyx_b, "print");
-        if (!__pyx_print)
-            return -1;
-    }
-    if (stream) {
-        kwargs = PyDict_New();
-        if (unlikely(!kwargs))
-            return -1;
-        if (unlikely(PyDict_SetItemString(kwargs, "file", stream) < 0))
-            goto bad;
-        if (!newline) {
-            end_string = PyUnicode_FromStringAndSize(" ", 1);
-            if (unlikely(!end_string))
-                goto bad;
-            if (PyDict_SetItemString(kwargs, "end", end_string) < 0) {
-                Py_DECREF(end_string);
-                goto bad;
-            }
-            Py_DECREF(end_string);
-        }
-    } else if (!newline) {
-        if (unlikely(!__pyx_print_kwargs)) {
-            __pyx_print_kwargs = PyDict_New();
-            if (unlikely(!__pyx_print_kwargs))
-                return -1;
-            end_string = PyUnicode_FromStringAndSize(" ", 1);
-            if (unlikely(!end_string))
-                return -1;
-            if (PyDict_SetItemString(__pyx_print_kwargs, "end", end_string) < 0) {
-                Py_DECREF(end_string);
-                return -1;
-            }
-            Py_DECREF(end_string);
-        }
-        kwargs = __pyx_print_kwargs;
-    }
-    result = PyObject_Call(__pyx_print, arg_tuple, kwargs);
-    if (unlikely(kwargs) && (kwargs != __pyx_print_kwargs))
-        Py_DECREF(kwargs);
-    if (!result)
-        return -1;
-    Py_DECREF(result);
-    return 0;
-bad:
-    if (kwargs != __pyx_print_kwargs)
-        Py_XDECREF(kwargs);
-    return -1;
-}
-
-#endif
-
-#if PY_MAJOR_VERSION < 3
-
-static int __Pyx_PrintOne(PyObject* f, PyObject *o) {
-    if (!f) {
-        if (!(f = __Pyx_GetStdout()))
-            return -1;
-    }
-    if (PyFile_SoftSpace(f, 0)) {
-        if (PyFile_WriteString(" ", f) < 0)
-            return -1;
-    }
-    if (PyFile_WriteObject(o, f, Py_PRINT_RAW) < 0)
-        return -1;
-    if (PyFile_WriteString("\n", f) < 0)
-        return -1;
-    return 0;
-    /* the line below is just to avoid compiler
-     * compiler warnings about unused functions */
-    return __Pyx_Print(f, NULL, 0);
-}
-
-#else /* Python 3 has a print function */
-
-static int __Pyx_PrintOne(PyObject* stream, PyObject *o) {
-    int res;
-    PyObject* arg_tuple = PyTuple_New(1);
-    if (unlikely(!arg_tuple))
-        return -1;
-    Py_INCREF(o);
-    PyTuple_SET_ITEM(arg_tuple, 0, o);
-    res = __Pyx_Print(stream, arg_tuple, 1);
-    Py_DECREF(arg_tuple);
-    return res;
-}
-
-#endif
-
-static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint64_t(uint64_t val) {
-    const uint64_t neg_one = (uint64_t)-1, const_zero = (uint64_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if ((sizeof(uint64_t) == sizeof(char))  ||
-        (sizeof(uint64_t) == sizeof(short))) {
-        return PyInt_FromLong((long)val);
-    } else if ((sizeof(uint64_t) == sizeof(int)) ||
-               (sizeof(uint64_t) == sizeof(long))) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLong((unsigned long)val);
-        else
-            return PyInt_FromLong((long)val);
-    } else if (sizeof(uint64_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
-        else
-            return PyLong_FromLongLong((PY_LONG_LONG)val);
-    } else {
-        int one = 1; int little = (int)*(unsigned char *)&one;
-        unsigned char *bytes = (unsigned char *)&val;
-        return _PyLong_FromByteArray(bytes, sizeof(uint64_t), 
-                                     little, !is_unsigned);
-    }
-}
-
-static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
-    const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned char" :
-                    "value too large to convert to unsigned char");
-            }
-            return (unsigned char)-1;
-        }
-        return (unsigned char)val;
-    }
-    return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
-    const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned short" :
-                    "value too large to convert to unsigned short");
-            }
-            return (unsigned short)-1;
-        }
-        return (unsigned short)val;
-    }
-    return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
-    const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned int" :
-                    "value too large to convert to unsigned int");
-            }
-            return (unsigned int)-1;
-        }
-        return (unsigned int)val;
-    }
-    return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
-    const char neg_one = (char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to char" :
-                    "value too large to convert to char");
-            }
-            return (char)-1;
-        }
-        return (char)val;
-    }
-    return (char)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
-    const short neg_one = (short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to short" :
-                    "value too large to convert to short");
-            }
-            return (short)-1;
-        }
-        return (short)val;
-    }
-    return (short)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
-    const int neg_one = (int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to int" :
-                    "value too large to convert to int");
-            }
-            return (int)-1;
-        }
-        return (int)val;
-    }
-    return (int)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
-    const signed char neg_one = (signed char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed char" :
-                    "value too large to convert to signed char");
-            }
-            return (signed char)-1;
-        }
-        return (signed char)val;
-    }
-    return (signed char)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
-    const signed short neg_one = (signed short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed short" :
-                    "value too large to convert to signed short");
-            }
-            return (signed short)-1;
-        }
-        return (signed short)val;
-    }
-    return (signed short)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
-    const signed int neg_one = (signed int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed int" :
-                    "value too large to convert to signed int");
-            }
-            return (signed int)-1;
-        }
-        return (signed int)val;
-    }
-    return (signed int)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
-    const int neg_one = (int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to int" :
-                    "value too large to convert to int");
-            }
-            return (int)-1;
-        }
-        return (int)val;
-    }
-    return (int)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
-    const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to unsigned long");
-            return (unsigned long)-1;
-        }
-        return (unsigned long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to unsigned long");
-                return (unsigned long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        unsigned long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (unsigned long)-1;
-        val = __Pyx_PyInt_AsUnsignedLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
-    const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to unsigned PY_LONG_LONG");
-            return (unsigned PY_LONG_LONG)-1;
-        }
-        return (unsigned PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to unsigned PY_LONG_LONG");
-                return (unsigned PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        unsigned PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (unsigned PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
-    const long neg_one = (long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to long");
-            return (long)-1;
-        }
-        return (long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to long");
-                return (long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (long)-1;
-        val = __Pyx_PyInt_AsLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
-    const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to PY_LONG_LONG");
-            return (PY_LONG_LONG)-1;
-        }
-        return (PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to PY_LONG_LONG");
-                return (PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
-    const signed long neg_one = (signed long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to signed long");
-            return (signed long)-1;
-        }
-        return (signed long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to signed long");
-                return (signed long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        signed long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (signed long)-1;
-        val = __Pyx_PyInt_AsSignedLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
-    const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to signed PY_LONG_LONG");
-            return (signed PY_LONG_LONG)-1;
-        }
-        return (signed PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to signed PY_LONG_LONG");
-                return (signed PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        signed PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (signed PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsSignedLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static void __Pyx_WriteUnraisable(const char *name) {
-    PyObject *old_exc, *old_val, *old_tb;
-    PyObject *ctx;
-    __Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
-    #if PY_MAJOR_VERSION < 3
-    ctx = PyString_FromString(name);
-    #else
-    ctx = PyUnicode_FromString(name);
-    #endif
-    __Pyx_ErrRestore(old_exc, old_val, old_tb);
-    if (!ctx) {
-        PyErr_WriteUnraisable(Py_None);
-    } else {
-        PyErr_WriteUnraisable(ctx);
-        Py_DECREF(ctx);
-    }
-}
-
-#ifndef __PYX_HAVE_RT_ImportType
-#define __PYX_HAVE_RT_ImportType
-static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
-    long size, int strict)
-{
-    PyObject *py_module = 0;
-    PyObject *result = 0;
-    PyObject *py_name = 0;
-    char warning[200];
-
-    py_module = __Pyx_ImportModule(module_name);
-    if (!py_module)
-        goto bad;
-    #if PY_MAJOR_VERSION < 3
-    py_name = PyString_FromString(class_name);
-    #else
-    py_name = PyUnicode_FromString(class_name);
-    #endif
-    if (!py_name)
-        goto bad;
-    result = PyObject_GetAttr(py_module, py_name);
-    Py_DECREF(py_name);
-    py_name = 0;
-    Py_DECREF(py_module);
-    py_module = 0;
-    if (!result)
-        goto bad;
-    if (!PyType_Check(result)) {
-        PyErr_Format(PyExc_TypeError, 
-            "%s.%s is not a type object",
-            module_name, class_name);
-        goto bad;
-    }
-    if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
-        PyOS_snprintf(warning, sizeof(warning), 
-            "%s.%s size changed, may indicate binary incompatibility",
-            module_name, class_name);
-        #if PY_VERSION_HEX < 0x02050000
-        PyErr_Warn(NULL, warning);
-        #else
-        PyErr_WarnEx(NULL, warning, 0);
-        #endif
-    }
-    else if (((PyTypeObject *)result)->tp_basicsize != size) {
-        PyErr_Format(PyExc_ValueError, 
-            "%s.%s has the wrong size, try recompiling",
-            module_name, class_name);
-        goto bad;
-    }
-    return (PyTypeObject *)result;
-bad:
-    Py_XDECREF(py_module);
-    Py_XDECREF(result);
-    return 0;
-}
-#endif
-
-#ifndef __PYX_HAVE_RT_ImportModule
-#define __PYX_HAVE_RT_ImportModule
-static PyObject *__Pyx_ImportModule(const char *name) {
-    PyObject *py_name = 0;
-    PyObject *py_module = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_name = PyString_FromString(name);
-    #else
-    py_name = PyUnicode_FromString(name);
-    #endif
-    if (!py_name)
-        goto bad;
-    py_module = PyImport_Import(py_name);
-    Py_DECREF(py_name);
-    return py_module;
-bad:
-    Py_XDECREF(py_name);
-    return 0;
-}
-#endif
-
-static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
-#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
-    PyObject *ob = PyCapsule_New(vtable, 0, 0);
-#else
-    PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
-#endif
-    if (!ob)
-        goto bad;
-    if (PyDict_SetItemString(dict, "__pyx_vtable__", ob) < 0)
-        goto bad;
-    Py_DECREF(ob);
-    return 0;
-bad:
-    Py_XDECREF(ob);
-    return -1;
-}
-
-#include "compile.h"
-#include "frameobject.h"
-#include "traceback.h"
-
-static void __Pyx_AddTraceback(const char *funcname) {
-    PyObject *py_srcfile = 0;
-    PyObject *py_funcname = 0;
-    PyObject *py_globals = 0;
-    PyCodeObject *py_code = 0;
-    PyFrameObject *py_frame = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_srcfile = PyString_FromString(__pyx_filename);
-    #else
-    py_srcfile = PyUnicode_FromString(__pyx_filename);
-    #endif
-    if (!py_srcfile) goto bad;
-    if (__pyx_clineno) {
-        #if PY_MAJOR_VERSION < 3
-        py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
-        #else
-        py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
-        #endif
-    }
-    else {
-        #if PY_MAJOR_VERSION < 3
-        py_funcname = PyString_FromString(funcname);
-        #else
-        py_funcname = PyUnicode_FromString(funcname);
-        #endif
-    }
-    if (!py_funcname) goto bad;
-    py_globals = PyModule_GetDict(__pyx_m);
-    if (!py_globals) goto bad;
-    py_code = PyCode_New(
-        0,            /*int argcount,*/
-        #if PY_MAJOR_VERSION >= 3
-        0,            /*int kwonlyargcount,*/
-        #endif
-        0,            /*int nlocals,*/
-        0,            /*int stacksize,*/
-        0,            /*int flags,*/
-        __pyx_empty_bytes, /*PyObject *code,*/
-        __pyx_empty_tuple,  /*PyObject *consts,*/
-        __pyx_empty_tuple,  /*PyObject *names,*/
-        __pyx_empty_tuple,  /*PyObject *varnames,*/
-        __pyx_empty_tuple,  /*PyObject *freevars,*/
-        __pyx_empty_tuple,  /*PyObject *cellvars,*/
-        py_srcfile,   /*PyObject *filename,*/
-        py_funcname,  /*PyObject *name,*/
-        __pyx_lineno,   /*int firstlineno,*/
-        __pyx_empty_bytes  /*PyObject *lnotab*/
-    );
-    if (!py_code) goto bad;
-    py_frame = PyFrame_New(
-        PyThreadState_GET(), /*PyThreadState *tstate,*/
-        py_code,             /*PyCodeObject *code,*/
-        py_globals,          /*PyObject *globals,*/
-        0                    /*PyObject *locals*/
-    );
-    if (!py_frame) goto bad;
-    py_frame->f_lineno = __pyx_lineno;
-    PyTraceBack_Here(py_frame);
-bad:
-    Py_XDECREF(py_srcfile);
-    Py_XDECREF(py_funcname);
-    Py_XDECREF(py_code);
-    Py_XDECREF(py_frame);
-}
-
-static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
-    while (t->p) {
-        #if PY_MAJOR_VERSION < 3
-        if (t->is_unicode) {
-            *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
-        } else if (t->intern) {
-            *t->p = PyString_InternFromString(t->s);
-        } else {
-            *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
-        }
-        #else  /* Python 3+ has unicode identifiers */
-        if (t->is_unicode | t->is_str) {
-            if (t->intern) {
-                *t->p = PyUnicode_InternFromString(t->s);
-            } else if (t->encoding) {
-                *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
-            } else {
-                *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
-            }
-        } else {
-            *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
-        }
-        #endif
-        if (!*t->p)
-            return -1;
-        ++t;
-    }
-    return 0;
-}
-
-/* Type Conversion Functions */
-
-static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
-   int is_true = x == Py_True;
-   if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
-   else return PyObject_IsTrue(x);
-}
-
-static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
-  PyNumberMethods *m;
-  const char *name = NULL;
-  PyObject *res = NULL;
-#if PY_VERSION_HEX < 0x03000000
-  if (PyInt_Check(x) || PyLong_Check(x))
-#else
-  if (PyLong_Check(x))
-#endif
-    return Py_INCREF(x), x;
-  m = Py_TYPE(x)->tp_as_number;
-#if PY_VERSION_HEX < 0x03000000
-  if (m && m->nb_int) {
-    name = "int";
-    res = PyNumber_Int(x);
-  }
-  else if (m && m->nb_long) {
-    name = "long";
-    res = PyNumber_Long(x);
-  }
-#else
-  if (m && m->nb_int) {
-    name = "int";
-    res = PyNumber_Long(x);
-  }
-#endif
-  if (res) {
-#if PY_VERSION_HEX < 0x03000000
-    if (!PyInt_Check(res) && !PyLong_Check(res)) {
-#else
-    if (!PyLong_Check(res)) {
-#endif
-      PyErr_Format(PyExc_TypeError,
-                   "__%s__ returned non-%s (type %.200s)",
-                   name, name, Py_TYPE(res)->tp_name);
-      Py_DECREF(res);
-      return NULL;
-    }
-  }
-  else if (!PyErr_Occurred()) {
-    PyErr_SetString(PyExc_TypeError,
-                    "an integer is required");
-  }
-  return res;
-}
-
-static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
-  Py_ssize_t ival;
-  PyObject* x = PyNumber_Index(b);
-  if (!x) return -1;
-  ival = PyInt_AsSsize_t(x);
-  Py_DECREF(x);
-  return ival;
-}
-
-static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
-#if PY_VERSION_HEX < 0x02050000
-   if (ival <= LONG_MAX)
-       return PyInt_FromLong((long)ival);
-   else {
-       unsigned char *bytes = (unsigned char *) &ival;
-       int one = 1; int little = (int)*(unsigned char*)&one;
-       return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
-   }
-#else
-   return PyInt_FromSize_t(ival);
-#endif
-}
-
-static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
-   unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
-   if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
-       return (size_t)-1;
-   } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
-       PyErr_SetString(PyExc_OverflowError,
-                       "value too large to convert to size_t");
-       return (size_t)-1;
-   }
-   return (size_t)val;
-}
-
-
-#endif /* Py_PYTHON_H */
diff --git a/pysam/ctabix.c b/pysam/ctabix.c
deleted file mode 100644 (file)
index 11a2c6f..0000000
+++ /dev/null
@@ -1,9005 +0,0 @@
-/* Generated by Cython 0.13 on Thu May  5 14:57:46 2011 */
-
-#define PY_SSIZE_T_CLEAN
-#include "Python.h"
-#ifndef Py_PYTHON_H
-    #error Python headers needed to compile C extensions, please install development version of Python.
-#else
-
-#include <stddef.h> /* For offsetof */
-#ifndef offsetof
-#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
-#endif
-
-#if !defined(WIN32) && !defined(MS_WINDOWS)
-  #ifndef __stdcall
-    #define __stdcall
-  #endif
-  #ifndef __cdecl
-    #define __cdecl
-  #endif
-  #ifndef __fastcall
-    #define __fastcall
-  #endif
-#endif
-
-#ifndef DL_IMPORT
-  #define DL_IMPORT(t) t
-#endif
-#ifndef DL_EXPORT
-  #define DL_EXPORT(t) t
-#endif
-
-#ifndef PY_LONG_LONG
-  #define PY_LONG_LONG LONG_LONG
-#endif
-
-#if PY_VERSION_HEX < 0x02040000
-  #define METH_COEXIST 0
-  #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
-  #define PyDict_Contains(d,o)   PySequence_Contains(d,o)
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  typedef int Py_ssize_t;
-  #define PY_SSIZE_T_MAX INT_MAX
-  #define PY_SSIZE_T_MIN INT_MIN
-  #define PY_FORMAT_SIZE_T ""
-  #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
-  #define PyInt_AsSsize_t(o)   PyInt_AsLong(o)
-  #define PyNumber_Index(o)    PyNumber_Int(o)
-  #define PyIndex_Check(o)     PyNumber_Check(o)
-  #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
-#endif
-
-#if PY_VERSION_HEX < 0x02060000
-  #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
-  #define Py_TYPE(ob)   (((PyObject*)(ob))->ob_type)
-  #define Py_SIZE(ob)   (((PyVarObject*)(ob))->ob_size)
-  #define PyVarObject_HEAD_INIT(type, size) \
-          PyObject_HEAD_INIT(type) size,
-  #define PyType_Modified(t)
-
-  typedef struct {
-     void *buf;
-     PyObject *obj;
-     Py_ssize_t len;
-     Py_ssize_t itemsize;
-     int readonly;
-     int ndim;
-     char *format;
-     Py_ssize_t *shape;
-     Py_ssize_t *strides;
-     Py_ssize_t *suboffsets;
-     void *internal;
-  } Py_buffer;
-
-  #define PyBUF_SIMPLE 0
-  #define PyBUF_WRITABLE 0x0001
-  #define PyBUF_FORMAT 0x0004
-  #define PyBUF_ND 0x0008
-  #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
-  #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
-  #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
-  #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
-  #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
-
-#endif
-
-#if PY_MAJOR_VERSION < 3
-  #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
-#else
-  #define __Pyx_BUILTIN_MODULE_NAME "builtins"
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define Py_TPFLAGS_CHECKTYPES 0
-  #define Py_TPFLAGS_HAVE_INDEX 0
-#endif
-
-#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
-  #define Py_TPFLAGS_HAVE_NEWBUFFER 0
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyBaseString_Type            PyUnicode_Type
-  #define PyStringObject               PyUnicodeObject
-  #define PyString_Type                PyUnicode_Type
-  #define PyString_Check               PyUnicode_Check
-  #define PyString_CheckExact          PyUnicode_CheckExact
-#endif
-
-#if PY_VERSION_HEX < 0x02060000
-  #define PyBytesObject                PyStringObject
-  #define PyBytes_Type                 PyString_Type
-  #define PyBytes_Check                PyString_Check
-  #define PyBytes_CheckExact           PyString_CheckExact
-  #define PyBytes_FromString           PyString_FromString
-  #define PyBytes_FromStringAndSize    PyString_FromStringAndSize
-  #define PyBytes_FromFormat           PyString_FromFormat
-  #define PyBytes_DecodeEscape         PyString_DecodeEscape
-  #define PyBytes_AsString             PyString_AsString
-  #define PyBytes_AsStringAndSize      PyString_AsStringAndSize
-  #define PyBytes_Size                 PyString_Size
-  #define PyBytes_AS_STRING            PyString_AS_STRING
-  #define PyBytes_GET_SIZE             PyString_GET_SIZE
-  #define PyBytes_Repr                 PyString_Repr
-  #define PyBytes_Concat               PyString_Concat
-  #define PyBytes_ConcatAndDel         PyString_ConcatAndDel
-  #define PySet_Check(obj)             PyObject_TypeCheck(obj, &PySet_Type)
-  #define PyFrozenSet_Check(obj)       PyObject_TypeCheck(obj, &PyFrozenSet_Type)
-#endif
-
-#ifndef PySet_CheckExact
-#  define PySet_CheckExact(obj)          (Py_TYPE(obj) == &PySet_Type)
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyInt_Type                   PyLong_Type
-  #define PyInt_Check(op)              PyLong_Check(op)
-  #define PyInt_CheckExact(op)         PyLong_CheckExact(op)
-  #define PyInt_FromString             PyLong_FromString
-  #define PyInt_FromUnicode            PyLong_FromUnicode
-  #define PyInt_FromLong               PyLong_FromLong
-  #define PyInt_FromSize_t             PyLong_FromSize_t
-  #define PyInt_FromSsize_t            PyLong_FromSsize_t
-  #define PyInt_AsLong                 PyLong_AsLong
-  #define PyInt_AS_LONG                PyLong_AS_LONG
-  #define PyInt_AsSsize_t              PyLong_AsSsize_t
-  #define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
-  #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyBoolObject PyLongObject
-#endif
-
-
-#if PY_MAJOR_VERSION >= 3
-  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
-  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
-#else
-  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
-  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
-#endif
-
-#if PY_MAJOR_VERSION >= 3
-  #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),((char *)(n)))
-  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
-  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),((char *)(n)))
-#else
-  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),(n))
-  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
-  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),(n))
-#endif
-
-#if PY_VERSION_HEX < 0x02050000
-  #define __Pyx_NAMESTR(n) ((char *)(n))
-  #define __Pyx_DOCSTR(n)  ((char *)(n))
-#else
-  #define __Pyx_NAMESTR(n) (n)
-  #define __Pyx_DOCSTR(n)  (n)
-#endif
-
-#ifdef __cplusplus
-#define __PYX_EXTERN_C extern "C"
-#else
-#define __PYX_EXTERN_C extern
-#endif
-
-#if defined(WIN32) || defined(MS_WINDOWS)
-#define _USE_MATH_DEFINES
-#endif
-#include <math.h>
-#define __PYX_HAVE_API__ctabix
-#include "string.h"
-#include "stdlib.h"
-#include "stdio.h"
-#include "ctype.h"
-#include "sys/types.h"
-#include "sys/stat.h"
-#include "fcntl.h"
-#include "unistd.h"
-#include "stdint.h"
-#include "bgzf.h"
-#include "tabix.h"
-#include "pythread.h"
-
-/* inline attribute */
-#ifndef CYTHON_INLINE
-  #if defined(__GNUC__)
-    #define CYTHON_INLINE __inline__
-  #elif defined(_MSC_VER)
-    #define CYTHON_INLINE __inline
-  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
-    #define CYTHON_INLINE inline
-  #else
-    #define CYTHON_INLINE 
-  #endif
-#endif
-
-/* unused attribute */
-#ifndef CYTHON_UNUSED
-# if defined(__GNUC__)
-#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
-#     define CYTHON_UNUSED __attribute__ ((__unused__)) 
-#   else
-#     define CYTHON_UNUSED
-#   endif
-# elif defined(__ICC) || defined(__INTEL_COMPILER)
-#   define CYTHON_UNUSED __attribute__ ((__unused__)) 
-# else
-#   define CYTHON_UNUSED 
-# endif
-#endif
-
-typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
-
-
-/* Type Conversion Predeclarations */
-
-#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
-#define __Pyx_PyBytes_AsUString(s)   ((unsigned char*) PyBytes_AsString(s))
-
-#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
-static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
-static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
-
-static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
-static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
-static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
-
-#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
-
-
-#ifdef __GNUC__
-/* Test for GCC > 2.95 */
-#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)) 
-#define likely(x)   __builtin_expect(!!(x), 1)
-#define unlikely(x) __builtin_expect(!!(x), 0)
-#else /* __GNUC__ > 2 ... */
-#define likely(x)   (x)
-#define unlikely(x) (x)
-#endif /* __GNUC__ > 2 ... */
-#else /* __GNUC__ */
-#define likely(x)   (x)
-#define unlikely(x) (x)
-#endif /* __GNUC__ */
-    
-static PyObject *__pyx_m;
-static PyObject *__pyx_b;
-static PyObject *__pyx_empty_tuple;
-static PyObject *__pyx_empty_bytes;
-static int __pyx_lineno;
-static int __pyx_clineno = 0;
-static const char * __pyx_cfilenm= __FILE__;
-static const char *__pyx_filename;
-
-
-static const char *__pyx_f[] = {
-  "ctabix.pyx",
-  "bool.pxd",
-  "TabProxies.pxd",
-};
-
-/* Type declarations */
-
-/* "pysam/ctabix.pxd":178
- *     cdef tabix_t * tabixfile
- * 
- * cdef class Parser:             # <<<<<<<<<<<<<<
- *      pass
- */
-
-struct __pyx_obj_6ctabix_Parser {
-  PyObject_HEAD
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":293
- *         return r
- * 
- * cdef class asVCF( Parser ):             # <<<<<<<<<<<<<<
- *     '''converts a :term:`tabix row` into a VCF record.'''
- *     def __call__(self, char * buffer, int len ):
- */
-
-struct __pyx_obj_6ctabix_asVCF {
-  struct __pyx_obj_6ctabix_Parser __pyx_base;
-};
-
-/* "pysam/TabProxies.pxd":42
- *   ctypedef int uint64_t
- * 
- * cdef class TupleProxy:             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_obj_10TabProxies_TupleProxy {
-  PyObject_HEAD
-  struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtab;
-  char *data;
-  char **fields;
-  int nfields;
-  int index;
-  int nbytes;
-  int offset;
-  int is_modified;
-};
-
-/* "pysam/TabProxies.pxd":77
- *     cdef update( self, char * buffer, size_t nbytes )
- * 
- * cdef class NamedTupleProxy( TupleProxy) :             # <<<<<<<<<<<<<<
- *     pass
- * 
- */
-
-struct __pyx_obj_10TabProxies_NamedTupleProxy {
-  struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
-};
-
-/* "pysam/TabProxies.pxd":80
- *     pass
- * 
- * cdef class BedProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_obj_10TabProxies_BedProxy {
-  struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
-  char *contig;
-  uint32_t start;
-  uint32_t end;
-  int bedfields;
-};
-
-/* "pysam/TabProxies.pxd":91
- *     cdef update( self, char * buffer, size_t nbytes )
- * 
- * cdef class VCFProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_obj_10TabProxies_VCFProxy {
-  struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
-  char *contig;
-  uint32_t pos;
-};
-
-/* "pysam/TabProxies.pxd":60
- *     cdef update( self, char * buffer, size_t nbytes )
- * 
- * cdef class GTFProxy( TupleProxy) :             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_obj_10TabProxies_GTFProxy {
-  struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
-  char *contig;
-  char *source;
-  char *feature;
-  uint32_t start;
-  uint32_t end;
-  char *score;
-  char *strand;
-  char *frame;
-  char *attributes;
-  int hasOwnAttributes;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":161
- *             return result
- * 
- * cdef class TabixIterator:             # <<<<<<<<<<<<<<
- *     """iterates over rows in *tabixfile* in region
- *     given by *tid*, *start* and *end*.
- */
-
-struct __pyx_obj_6ctabix_TabixIterator {
-  PyObject_HEAD
-  ti_iter_t iterator;
-  tabix_t *tabixfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":304
- * #########################################################
- * #########################################################
- * cdef class TabixIteratorParsed:             # <<<<<<<<<<<<<<
- *     """iterates over mapped reads in a region.
- * 
- */
-
-struct __pyx_obj_6ctabix_TabixIteratorParsed {
-  PyObject_HEAD
-  ti_iter_t iterator;
-  tabix_t *tabixfile;
-  struct __pyx_obj_6ctabix_Parser *parser;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":216
- *             ti_iter_destroy(self.iterator)
- * 
- * cdef class TabixHeaderIterator:             # <<<<<<<<<<<<<<
- *     """return header lines.
- *     """
- */
-
-struct __pyx_obj_6ctabix_TabixHeaderIterator {
-  PyObject_HEAD
-  ti_iter_t iterator;
-  tabix_t *tabixfile;
-};
-
-/* "pysam/ctabix.pxd":172
- *   # char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
- * 
- * cdef class Tabixfile:             # <<<<<<<<<<<<<<
- *     cdef char * filename
- * 
- */
-
-struct __pyx_obj_6ctabix_Tabixfile {
-  PyObject_HEAD
-  char *filename;
-  tabix_t *tabixfile;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":277
- *         return r
- * 
- * cdef class asGTF(Parser):             # <<<<<<<<<<<<<<
- *     '''converts a :term:`tabix row` into a GTF record.'''
- *     def __call__(self, char * buffer, int len):
- */
-
-struct __pyx_obj_6ctabix_asGTF {
-  struct __pyx_obj_6ctabix_Parser __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":285
- *         return r
- * 
- * cdef class asBed( Parser ):             # <<<<<<<<<<<<<<
- *     '''converts a :term:`tabix row` into a GTF record.'''
- *     def __call__(self, char * buffer, int len):
- */
-
-struct __pyx_obj_6ctabix_asBed {
-  struct __pyx_obj_6ctabix_Parser __pyx_base;
-};
-
-/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":267
- *     pass
- * 
- * cdef class asTuple(Parser):             # <<<<<<<<<<<<<<
- *     '''converts a :term:`tabix row` into a python tuple.'''
- *     def __call__(self, char * buffer, int len):
- */
-
-struct __pyx_obj_6ctabix_asTuple {
-  struct __pyx_obj_6ctabix_Parser __pyx_base;
-};
-
-
-/* "pysam/TabProxies.pxd":42
- *   ctypedef int uint64_t
- * 
- * cdef class TupleProxy:             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_vtabstruct_10TabProxies_TupleProxy {
-  int (*getMaxFields)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t);
-  PyObject *(*take)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
-  PyObject *(*present)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
-  PyObject *(*copy)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
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- * cdef class NamedTupleProxy( TupleProxy) :             # <<<<<<<<<<<<<<
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- * 
- */
-
-struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy {
-  struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
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-static struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
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-
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- *     cdef update( self, char * buffer, size_t nbytes )
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- * cdef class VCFProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
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- *     cdef:
- */
-
-struct __pyx_vtabstruct_10TabProxies_VCFProxy {
-  struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
-};
-static struct __pyx_vtabstruct_10TabProxies_VCFProxy *__pyx_vtabptr_10TabProxies_VCFProxy;
-
-
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- * cdef class BedProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
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- *     cdef:
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-
-struct __pyx_vtabstruct_10TabProxies_BedProxy {
-  struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
-};
-static struct __pyx_vtabstruct_10TabProxies_BedProxy *__pyx_vtabptr_10TabProxies_BedProxy;
-
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- *     cdef update( self, char * buffer, size_t nbytes )
- * 
- * cdef class GTFProxy( TupleProxy) :             # <<<<<<<<<<<<<<
- * 
- *     cdef:
- */
-
-struct __pyx_vtabstruct_10TabProxies_GTFProxy {
-  struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
-};
-static struct __pyx_vtabstruct_10TabProxies_GTFProxy *__pyx_vtabptr_10TabProxies_GTFProxy;
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-
-#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
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-            PyObject *r = PyList_GET_ITEM(o, i);
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-        else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
-            PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
-            Py_INCREF(r);
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-#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
-                                                    __Pyx_GetItemInt_Tuple_Fast(o, i) : \
-                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
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-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
-    if (likely(o != Py_None)) {
-        if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
-            PyObject *r = PyTuple_GET_ITEM(o, i);
-            Py_INCREF(r);
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-        else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
-            PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
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-    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
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-
-#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
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-static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
-    PyObject *r;
-    if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
-        r = PyList_GET_ITEM(o, i);
-        Py_INCREF(r);
-    }
-    else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
-        r = PyTuple_GET_ITEM(o, i);
-        Py_INCREF(r);
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-    else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
-        r = PySequence_GetItem(o, i);
-    }
-    else {
-        r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
-    }
-    return r;
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-
-static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
-
-static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
-
-static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
-static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
-
-static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
-    const char *name, int exact); /*proto*/
-
-static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
-
-
-#if PY_MAJOR_VERSION >= 3
-static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
-    PyObject *value;
-    if (unlikely(d == Py_None)) {
-        __Pyx_RaiseNoneIndexingError();
-        return NULL;
-    }
-    value = PyDict_GetItemWithError(d, key);
-    if (unlikely(!value)) {
-        if (!PyErr_Occurred())
-            PyErr_SetObject(PyExc_KeyError, key);
-        return NULL;
-    }
-    Py_INCREF(value);
-    return value;
-}
-#else
-    #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
-#endif
-
-static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-
-static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-
-static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
-
-static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
-
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
-
-static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject *);
-
-static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
-
-static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
-
-static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
-
-static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
-
-static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
-
-static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
-
-static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
-
-static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
-
-static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
-
-static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
-
-static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
-
-static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
-
-static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
-
-static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
-
-static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
-
-static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
-
-static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict);  /*proto*/
-
-static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
-
-static int __Pyx_GetVtable(PyObject *dict, void *vtabptr); /*proto*/
-
-static void __Pyx_AddTraceback(const char *funcname); /*proto*/
-
-static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
-/* Module declarations from cpython.version */
-
-/* Module declarations from cpython.ref */
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-/* Module declarations from cpython.exc */
-
-/* Module declarations from cpython.module */
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-/* Module declarations from cpython.type */
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-
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-
-/* Module declarations from cpython.string */
-
-/* Module declarations from cpython.unicode */
-
-/* Module declarations from cpython.dict */
-
-/* Module declarations from cpython.instance */
-
-/* Module declarations from cpython.function */
-
-/* Module declarations from cpython.method */
-
-/* Module declarations from cpython.weakref */
-
-/* Module declarations from cpython.getargs */
-
-/* Module declarations from cpython.pythread */
-
-/* Module declarations from cpython.cobject */
-
-/* Module declarations from cpython.oldbuffer */
-
-/* Module declarations from cpython.set */
-
-/* Module declarations from cpython.buffer */
-
-/* Module declarations from cpython.bytes */
-
-/* Module declarations from cpython.pycapsule */
-
-/* Module declarations from cpython */
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-static PyTypeObject *__pyx_ptype_10TabProxies_TupleProxy = 0;
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-static PyTypeObject *__pyx_ptype_10TabProxies_NamedTupleProxy = 0;
-static PyTypeObject *__pyx_ptype_10TabProxies_BedProxy = 0;
-static PyTypeObject *__pyx_ptype_10TabProxies_VCFProxy = 0;
-/* Module declarations from ctabix */
-
-static PyTypeObject *__pyx_ptype_6ctabix_Tabixfile = 0;
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-static PyTypeObject *__pyx_ptype_6ctabix_TabixHeaderIterator = 0;
-static PyTypeObject *__pyx_ptype_6ctabix_asTuple = 0;
-static PyTypeObject *__pyx_ptype_6ctabix_asGTF = 0;
-static PyTypeObject *__pyx_ptype_6ctabix_asBed = 0;
-static PyTypeObject *__pyx_ptype_6ctabix_asVCF = 0;
-static PyTypeObject *__pyx_ptype_6ctabix_TabixIteratorParsed = 0;
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-
-/* Implementation of ctabix */
-static PyObject *__pyx_builtin_IOError;
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-static PyObject *__pyx_builtin_StopIteration;
-static PyObject *__pyx_builtin_OSError;
-static PyObject *__pyx_builtin_ord;
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-static char __pyx_k_1[] = "invalid file opening mode `%s`";
-static char __pyx_k_2[] = ".tbi";
-static char __pyx_k_3[] = "file `%s` not found";
-static char __pyx_k_4[] = "index `%s` not found";
-static char __pyx_k_5[] = "could not open file `%s`";
-static char __pyx_k_6[] = "%s:%i-%i";
-static char __pyx_k_7[] = "invalid region `%s`";
-static char __pyx_k_8[] = "invalid region: start (%i) > end (%i)";
-static char __pyx_k_9[] = "start out of range (%i)";
-static char __pyx_k_10[] = "end out of range (%i)";
-static char __pyx_k_11[] = "I/O operation on closed file";
-static char __pyx_k_12[] = "malformatted query or wrong sequence name.\n";
-static char __pyx_k_13[] = "can't open header.\n";
-static char __pyx_k_15[] = "Filename '%s' already exists, use *force* to overwrite";
-static char __pyx_k_16[] = "could not open '%s' for writing";
-static char __pyx_k_17[] = "could not open '%s' for reading";
-static char __pyx_k_18[] = "writing failed";
-static char __pyx_k_20[] = "#";
-static char __pyx_k_22[] = "No such file '%s'";
-static char __pyx_k_23[] = ".gz";
-static char __pyx_k_24[] = "Filename '%s.tbi' already exists, use *force* to overwrite";
-static char __pyx_k_25[] = "unknown preset '%s', valid presets are '%s'";
-static char __pyx_k_26[] = ",";
-static char __pyx_k_27[] = "chromosome names";
-static char __pyx_k_28[] = "Tabixfile._isOpen (line 19)";
-static char __pyx_k_29[] = "Tabixfile._open (line 23)";
-static char __pyx_k_30[] = "Tabixfile._parseRegion (line 57)";
-static char __pyx_k_31[] = "Tabixfile.fetch (line 102)";
-static char __pyx_k_32[] = "Tabixfile.header.__get__ (line 140)";
-static char __pyx_k_33[] = "TabixIterator.__next__ (line 192)";
-static char __pyx_k_34[] = "TabixHeaderIterator.__next__ (line 239)";
-static char __pyx_k_35[] = "TabixIteratorParsed.__next__ (line 342)";
-static char __pyx_k_36[] = "tabix_compress (line 362)";
-static char __pyx_k_37[] = "tabix_index (line 407)";
-static char __pyx_k__r[] = "r";
-static char __pyx_k__w[] = "w";
-static char __pyx_k__bc[] = "bc";
-static char __pyx_k__ec[] = "ec";
-static char __pyx_k__fp[] = "fp";
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- *             raise IOError("could not open file `%s`" % filename )
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- *     def _parseRegion( self,
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- *     def _parseRegion( self,             # <<<<<<<<<<<<<<
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-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__region);
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- *     def _parseRegion( self,
- *                       reference = None,             # <<<<<<<<<<<<<<
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- *                       region = None ):
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- *                       region = None ):             # <<<<<<<<<<<<<<
- *         '''parse region information.
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-    __pyx_v_region = ((PyObject *)Py_None);
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-  goto __pyx_L4_argument_unpacking_done;
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- *         cdef int rtid
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-  ti_lazy_index_load(((struct __pyx_obj_6ctabix_Tabixfile *)__pyx_v_self)->tabixfile);
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- *         cdef int rend
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- *         rtid = rstart = rend = 0
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- *         rtid = rstart = rend = 0             # <<<<<<<<<<<<<<
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- *                 region = reference             # <<<<<<<<<<<<<<
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-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":93
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- *         if region:             # <<<<<<<<<<<<<<
- *             ti_parse_region( self.tabixfile.idx, region, &rtid, &rstart, &rend)
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-  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_region); if (unlikely(__pyx_t_1 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 93; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-
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- *         if region:
- *             ti_parse_region( self.tabixfile.idx, region, &rtid, &rstart, &rend)             # <<<<<<<<<<<<<<
- *             if rtid < 0: raise ValueError( "invalid region `%s`" % region )
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-      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
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-      __Pyx_GOTREF(__pyx_t_2);
-      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
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- *             if not 0 <= rstart < max_pos: raise ValueError( 'start out of range (%i)' % rstart )
- *             if not 0 <= rend < max_pos: raise ValueError( 'end out of range (%i)' % rend )
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- *             if not 0 <= rstart < max_pos: raise ValueError( 'start out of range (%i)' % rstart )
- *             if not 0 <= rend < max_pos: raise ValueError( 'end out of range (%i)' % rend )             # <<<<<<<<<<<<<<
- * 
- *         return region, rtid, rstart, rend
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- *     def fetch( self,             # <<<<<<<<<<<<<<
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- *                region = None,             # <<<<<<<<<<<<<<
- *                parser = None ):
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- * 
- *     def fetch( self,
- *                reference = None,             # <<<<<<<<<<<<<<
- *                start = None,
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- *     def fetch( self,
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- *                end = None,             # <<<<<<<<<<<<<<
- *                region = None,
- *                parser = None ):
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-      case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
-      case  0: break;
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-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  0:
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-      else goto __pyx_L5_argtuple_error;
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-        __Pyx_RaiseArgtupleInvalid("tabix_compress", 0, 2, 3, 1); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 362; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
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-      case  2:
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-        PyObject* value = PyDict_GetItem(__pyx_kwds, __pyx_n_s__force);
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-    switch (PyTuple_GET_SIZE(__pyx_args)) {
-      case  3:
-      __pyx_v_force = PyTuple_GET_ITEM(__pyx_args, 2);
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-      __pyx_v_filename_out = PyTuple_GET_ITEM(__pyx_args, 1);
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-      default: goto __pyx_L5_argtuple_error;
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-  __Pyx_RaiseArgtupleInvalid("tabix_compress", 0, 2, 3, PyTuple_GET_SIZE(__pyx_args)); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 362; __pyx_clineno = __LINE__; goto __pyx_L3_error;}
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-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":372
- *     '''
- * 
- *     if not force and os.path.exists(filename_out ):             # <<<<<<<<<<<<<<
- *         raise IOError( "Filename '%s' already exists, use *force* to overwrite" % filename_out)
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-  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_force); if (unlikely(__pyx_t_1 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 372; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_t_2 = (!__pyx_t_1);
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-    __Pyx_GOTREF(__pyx_t_3);
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-    __Pyx_GOTREF(__pyx_t_4);
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-    __Pyx_GOTREF(__pyx_t_3);
-    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
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-    __Pyx_GOTREF(__pyx_t_4);
-    __Pyx_INCREF(__pyx_v_filename_out);
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-    __Pyx_GOTREF(__pyx_t_5);
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-    __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_1 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 372; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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-
-    /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":373
- * 
- *     if not force and os.path.exists(filename_out ):
- *         raise IOError( "Filename '%s' already exists, use *force* to overwrite" % filename_out)             # <<<<<<<<<<<<<<
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- *     cdef int WINDOW_SIZE
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-    __pyx_t_5 = PyNumber_Remainder(((PyObject *)__pyx_kp_s_15), __pyx_v_filename_out); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 373; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(((PyObject *)__pyx_t_5));
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-    __Pyx_GOTREF(__pyx_t_4);
-    PyTuple_SET_ITEM(__pyx_t_4, 0, ((PyObject *)__pyx_t_5));
-    __Pyx_GIVEREF(((PyObject *)__pyx_t_5));
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-    __pyx_t_5 = PyObject_Call(__pyx_builtin_IOError, __pyx_t_4, NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 373; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
-    __Pyx_Raise(__pyx_t_5, 0, 0);
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 373; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L6;
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-  __pyx_L6:;
-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":382
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- *     cdef int O_RDONLY
- *     O_RDONLY = os.O_RDONLY             # <<<<<<<<<<<<<<
- * 
- *     WINDOW_SIZE = 64 * 1024
- */
-  __pyx_t_5 = __Pyx_GetName(__pyx_m, __pyx_n_s__os); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 382; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_5);
-  __pyx_t_4 = PyObject_GetAttr(__pyx_t_5, __pyx_n_s__O_RDONLY); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 382; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_4);
-  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-  __pyx_t_7 = __Pyx_PyInt_AsInt(__pyx_t_4); if (unlikely((__pyx_t_7 == (int)-1) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 382; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
-  __pyx_v_O_RDONLY = __pyx_t_7;
-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":384
- *     O_RDONLY = os.O_RDONLY
- * 
- *     WINDOW_SIZE = 64 * 1024             # <<<<<<<<<<<<<<
- * 
- *     fp = bgzf_open( filename_out, "w")
- */
-  __pyx_v_WINDOW_SIZE = 65536;
-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":386
- *     WINDOW_SIZE = 64 * 1024
- * 
- *     fp = bgzf_open( filename_out, "w")             # <<<<<<<<<<<<<<
- *     if fp == NULL:
- *         raise IOError( "could not open '%s' for writing" )
- */
-  __pyx_t_8 = PyBytes_AsString(__pyx_v_filename_out); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 386; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_v_fp = bgzf_open(__pyx_t_8, __pyx_k__w);
-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":387
- * 
- *     fp = bgzf_open( filename_out, "w")
- *     if fp == NULL:             # <<<<<<<<<<<<<<
- *         raise IOError( "could not open '%s' for writing" )
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- */
-  __pyx_t_6 = (__pyx_v_fp == NULL);
-  if (__pyx_t_6) {
-
-    /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":388
- *     fp = bgzf_open( filename_out, "w")
- *     if fp == NULL:
- *         raise IOError( "could not open '%s' for writing" )             # <<<<<<<<<<<<<<
- * 
- *     fd_src = open(filename_in, O_RDONLY)
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-    __pyx_t_4 = PyTuple_New(1); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 388; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_4);
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-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_16));
-    __pyx_t_5 = PyObject_Call(__pyx_builtin_IOError, __pyx_t_4, NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 388; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
-    __Pyx_Raise(__pyx_t_5, 0, 0);
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
-    {__pyx_filename = __pyx_f[0]; __pyx_lineno = 388; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    goto __pyx_L7;
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-  __pyx_L7:;
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-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":390
- *         raise IOError( "could not open '%s' for writing" )
- * 
- *     fd_src = open(filename_in, O_RDONLY)             # <<<<<<<<<<<<<<
- *     if fd_src == 0:
- *         raise IOError( "could not open '%s' for reading" )
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-  __pyx_t_8 = PyBytes_AsString(__pyx_v_filename_in); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 390; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_v_fd_src = open(__pyx_t_8, __pyx_v_O_RDONLY);
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- *     fd_src = open(filename_in, O_RDONLY)
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- *         raise IOError( "could not open '%s' for reading" )
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-
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- *     if fd_src == 0:
- *         raise IOError( "could not open '%s' for reading" )             # <<<<<<<<<<<<<<
- * 
- *     buffer = malloc(WINDOW_SIZE)
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-    __pyx_t_5 = PyTuple_New(1); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 392; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_5);
-    __Pyx_INCREF(((PyObject *)__pyx_kp_s_17));
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-    __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_17));
-    __pyx_t_4 = PyObject_Call(__pyx_builtin_IOError, __pyx_t_5, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 392; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    __Pyx_GOTREF(__pyx_t_4);
-    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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-    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
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-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":394
- *         raise IOError( "could not open '%s' for reading" )
- * 
- *     buffer = malloc(WINDOW_SIZE)             # <<<<<<<<<<<<<<
- * 
- *     while c > 0:
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-
-  /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":396
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- * 
- *     while c > 0:             # <<<<<<<<<<<<<<
- *         c = read(fd_src, buffer, WINDOW_SIZE)
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- *         r = bgzf_write(fp, buffer, c)
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-
-    /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":398
- *     while c > 0:
- *         c = read(fd_src, buffer, WINDOW_SIZE)
- *         r = bgzf_write(fp, buffer, c)             # <<<<<<<<<<<<<<
- *         if r < 0:
- *             free( buffer )
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-
-    /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":399
- *         c = read(fd_src, buffer, WINDOW_SIZE)
- *         r = bgzf_write(fp, buffer, c)
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- *             free( buffer )
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-
-      /* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":400
- *         r = bgzf_write(fp, buffer, c)
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- *             free( buffer )             # <<<<<<<<<<<<<<
- *             raise OSError("writing failed")
- * 
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- *             free( buffer )
- *             raise OSError("writing failed")             # <<<<<<<<<<<<<<
- * 
- *     free( buffer )
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-      __pyx_t_4 = PyTuple_New(1); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 401; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-      __Pyx_GOTREF(__pyx_t_4);
-      __Pyx_INCREF(((PyObject *)__pyx_kp_s_18));
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-      __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_18));
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-      __Pyx_GOTREF(__pyx_t_5);
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-      __Pyx_Raise(__pyx_t_5, 0, 0);
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- *     cdef ti_conf_t conf
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-  #if PY_VERSION_HEX >= 0x02050000
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-static PySequenceMethods __pyx_tp_as_sequence_TabixIterator = {
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-  sizeof(struct __pyx_obj_6ctabix_TabixIterator), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_TabixIterator, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_TabixIterator, /*tp_as_number*/
-  &__pyx_tp_as_sequence_TabixIterator, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_TabixIterator, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_TabixIterator, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("iterates over rows in *tabixfile* in region\n    given by *tid*, *start* and *end*.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_6ctabix_13TabixIterator___iter__, /*tp_iter*/
-  __pyx_pf_6ctabix_13TabixIterator___next__, /*tp_iternext*/
-  __pyx_methods_6ctabix_TabixIterator, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_TabixIterator, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_TabixHeaderIterator(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  if (__pyx_pf_6ctabix_19TabixHeaderIterator___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_6ctabix_TabixHeaderIterator(PyObject *o) {
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_6ctabix_19TabixHeaderIterator___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static PyMethodDef __pyx_methods_6ctabix_TabixHeaderIterator[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_6ctabix_19TabixHeaderIterator___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_6ctabix_19TabixHeaderIterator___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_TabixHeaderIterator = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_TabixHeaderIterator = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_TabixHeaderIterator = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_TabixHeaderIterator = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_TabixHeaderIterator = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.TabixHeaderIterator"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_TabixHeaderIterator), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_TabixHeaderIterator, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_TabixHeaderIterator, /*tp_as_number*/
-  &__pyx_tp_as_sequence_TabixHeaderIterator, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_TabixHeaderIterator, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  0, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_TabixHeaderIterator, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("return header lines.\n    "), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  __pyx_pf_6ctabix_19TabixHeaderIterator___iter__, /*tp_iter*/
-  __pyx_pf_6ctabix_19TabixHeaderIterator___next__, /*tp_iternext*/
-  __pyx_methods_6ctabix_TabixHeaderIterator, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_TabixHeaderIterator, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_asTuple(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
-  if (!o) return 0;
-  return o;
-}
-
-static PyMethodDef __pyx_methods_6ctabix_asTuple[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_asTuple = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_asTuple = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_asTuple = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_asTuple = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_asTuple = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.asTuple"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_asTuple), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_asTuple, /*tp_as_number*/
-  &__pyx_tp_as_sequence_asTuple, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_asTuple, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  __pyx_pf_6ctabix_7asTuple___call__, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_asTuple, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("converts a :term:`tabix row` into a python tuple."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_6ctabix_asTuple, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_asTuple, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_asGTF(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
-  if (!o) return 0;
-  return o;
-}
-
-static PyMethodDef __pyx_methods_6ctabix_asGTF[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_asGTF = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_asGTF = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_asGTF = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_asGTF = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_asGTF = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.asGTF"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_asGTF), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_asGTF, /*tp_as_number*/
-  &__pyx_tp_as_sequence_asGTF, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_asGTF, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  __pyx_pf_6ctabix_5asGTF___call__, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_asGTF, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("converts a :term:`tabix row` into a GTF record."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_6ctabix_asGTF, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_asGTF, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_asBed(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
-  if (!o) return 0;
-  return o;
-}
-
-static PyMethodDef __pyx_methods_6ctabix_asBed[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_asBed = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_asBed = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_asBed = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_asBed = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_asBed = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.asBed"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_asBed), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_asBed, /*tp_as_number*/
-  &__pyx_tp_as_sequence_asBed, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_asBed, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  __pyx_pf_6ctabix_5asBed___call__, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_asBed, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("converts a :term:`tabix row` into a GTF record."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_6ctabix_asBed, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_asBed, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_asVCF(PyTypeObject *t, PyObject *a, PyObject *k) {
-  PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
-  if (!o) return 0;
-  return o;
-}
-
-static PyMethodDef __pyx_methods_6ctabix_asVCF[] = {
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_asVCF = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_asVCF = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_asVCF = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_asVCF = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_asVCF = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.asVCF"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_asVCF), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*tp_repr*/
-  &__pyx_tp_as_number_asVCF, /*tp_as_number*/
-  &__pyx_tp_as_sequence_asVCF, /*tp_as_sequence*/
-  &__pyx_tp_as_mapping_asVCF, /*tp_as_mapping*/
-  0, /*tp_hash*/
-  __pyx_pf_6ctabix_5asVCF___call__, /*tp_call*/
-  0, /*tp_str*/
-  0, /*tp_getattro*/
-  0, /*tp_setattro*/
-  &__pyx_tp_as_buffer_asVCF, /*tp_as_buffer*/
-  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
-  __Pyx_DOCSTR("converts a :term:`tabix row` into a VCF record."), /*tp_doc*/
-  0, /*tp_traverse*/
-  0, /*tp_clear*/
-  0, /*tp_richcompare*/
-  0, /*tp_weaklistoffset*/
-  0, /*tp_iter*/
-  0, /*tp_iternext*/
-  __pyx_methods_6ctabix_asVCF, /*tp_methods*/
-  0, /*tp_members*/
-  0, /*tp_getset*/
-  0, /*tp_base*/
-  0, /*tp_dict*/
-  0, /*tp_descr_get*/
-  0, /*tp_descr_set*/
-  0, /*tp_dictoffset*/
-  0, /*tp_init*/
-  0, /*tp_alloc*/
-  __pyx_tp_new_6ctabix_asVCF, /*tp_new*/
-  0, /*tp_free*/
-  0, /*tp_is_gc*/
-  0, /*tp_bases*/
-  0, /*tp_mro*/
-  0, /*tp_cache*/
-  0, /*tp_subclasses*/
-  0, /*tp_weaklist*/
-  0, /*tp_del*/
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*tp_version_tag*/
-  #endif
-};
-
-static PyObject *__pyx_tp_new_6ctabix_TabixIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k) {
-  struct __pyx_obj_6ctabix_TabixIteratorParsed *p;
-  PyObject *o = (*t->tp_alloc)(t, 0);
-  if (!o) return 0;
-  p = ((struct __pyx_obj_6ctabix_TabixIteratorParsed *)o);
-  p->parser = ((struct __pyx_obj_6ctabix_Parser *)Py_None); Py_INCREF(Py_None);
-  if (__pyx_pf_6ctabix_19TabixIteratorParsed___cinit__(o, a, k) < 0) {
-    Py_DECREF(o); o = 0;
-  }
-  return o;
-}
-
-static void __pyx_tp_dealloc_6ctabix_TabixIteratorParsed(PyObject *o) {
-  struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
-  {
-    PyObject *etype, *eval, *etb;
-    PyErr_Fetch(&etype, &eval, &etb);
-    ++Py_REFCNT(o);
-    __pyx_pf_6ctabix_19TabixIteratorParsed___dealloc__(o);
-    if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
-    --Py_REFCNT(o);
-    PyErr_Restore(etype, eval, etb);
-  }
-  Py_XDECREF(((PyObject *)p->parser));
-  (*Py_TYPE(o)->tp_free)(o);
-}
-
-static int __pyx_tp_traverse_6ctabix_TabixIteratorParsed(PyObject *o, visitproc v, void *a) {
-  int e;
-  struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
-  if (p->parser) {
-    e = (*v)(((PyObject*)p->parser), a); if (e) return e;
-  }
-  return 0;
-}
-
-static int __pyx_tp_clear_6ctabix_TabixIteratorParsed(PyObject *o) {
-  struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
-  PyObject* tmp;
-  tmp = ((PyObject*)p->parser);
-  p->parser = ((struct __pyx_obj_6ctabix_Parser *)Py_None); Py_INCREF(Py_None);
-  Py_XDECREF(tmp);
-  return 0;
-}
-
-static PyMethodDef __pyx_methods_6ctabix_TabixIteratorParsed[] = {
-  {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_6ctabix_19TabixIteratorParsed___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_6ctabix_19TabixIteratorParsed___next__)},
-  {0, 0, 0, 0}
-};
-
-static PyNumberMethods __pyx_tp_as_number_TabixIteratorParsed = {
-  0, /*nb_add*/
-  0, /*nb_subtract*/
-  0, /*nb_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_divide*/
-  #endif
-  0, /*nb_remainder*/
-  0, /*nb_divmod*/
-  0, /*nb_power*/
-  0, /*nb_negative*/
-  0, /*nb_positive*/
-  0, /*nb_absolute*/
-  0, /*nb_nonzero*/
-  0, /*nb_invert*/
-  0, /*nb_lshift*/
-  0, /*nb_rshift*/
-  0, /*nb_and*/
-  0, /*nb_xor*/
-  0, /*nb_or*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_coerce*/
-  #endif
-  0, /*nb_int*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_long*/
-  #else
-  0, /*reserved*/
-  #endif
-  0, /*nb_float*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_oct*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_hex*/
-  #endif
-  0, /*nb_inplace_add*/
-  0, /*nb_inplace_subtract*/
-  0, /*nb_inplace_multiply*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*nb_inplace_divide*/
-  #endif
-  0, /*nb_inplace_remainder*/
-  0, /*nb_inplace_power*/
-  0, /*nb_inplace_lshift*/
-  0, /*nb_inplace_rshift*/
-  0, /*nb_inplace_and*/
-  0, /*nb_inplace_xor*/
-  0, /*nb_inplace_or*/
-  0, /*nb_floor_divide*/
-  0, /*nb_true_divide*/
-  0, /*nb_inplace_floor_divide*/
-  0, /*nb_inplace_true_divide*/
-  #if PY_VERSION_HEX >= 0x02050000
-  0, /*nb_index*/
-  #endif
-};
-
-static PySequenceMethods __pyx_tp_as_sequence_TabixIteratorParsed = {
-  0, /*sq_length*/
-  0, /*sq_concat*/
-  0, /*sq_repeat*/
-  0, /*sq_item*/
-  0, /*sq_slice*/
-  0, /*sq_ass_item*/
-  0, /*sq_ass_slice*/
-  0, /*sq_contains*/
-  0, /*sq_inplace_concat*/
-  0, /*sq_inplace_repeat*/
-};
-
-static PyMappingMethods __pyx_tp_as_mapping_TabixIteratorParsed = {
-  0, /*mp_length*/
-  0, /*mp_subscript*/
-  0, /*mp_ass_subscript*/
-};
-
-static PyBufferProcs __pyx_tp_as_buffer_TabixIteratorParsed = {
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getreadbuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getwritebuffer*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getsegcount*/
-  #endif
-  #if PY_MAJOR_VERSION < 3
-  0, /*bf_getcharbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_getbuffer*/
-  #endif
-  #if PY_VERSION_HEX >= 0x02060000
-  0, /*bf_releasebuffer*/
-  #endif
-};
-
-PyTypeObject __pyx_type_6ctabix_TabixIteratorParsed = {
-  PyVarObject_HEAD_INIT(0, 0)
-  __Pyx_NAMESTR("ctabix.TabixIteratorParsed"), /*tp_name*/
-  sizeof(struct __pyx_obj_6ctabix_TabixIteratorParsed), /*tp_basicsize*/
-  0, /*tp_itemsize*/
-  __pyx_tp_dealloc_6ctabix_TabixIteratorParsed, /*tp_dealloc*/
-  0, /*tp_print*/
-  0, /*tp_getattr*/
-  0, /*tp_setattr*/
-  #if PY_MAJOR_VERSION < 3
-  0, /*tp_compare*/
-  #else
-  0, /*reserved*/
-  #endif
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-  0, /*tp_str*/
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-  __pyx_builtin_ValueError = __Pyx_GetName(__pyx_b, __pyx_n_s__ValueError); if (!__pyx_builtin_ValueError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 95; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  __pyx_builtin_OSError = __Pyx_GetName(__pyx_b, __pyx_n_s__OSError); if (!__pyx_builtin_OSError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 401; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  return -1;
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-  __pyx_int_5 = PyInt_FromLong(5); if (unlikely(!__pyx_int_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  __pyx_int_neg_1 = PyInt_FromLong(-1); if (unlikely(!__pyx_int_neg_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  __pyx_int_15 = PyInt_FromLong(15); if (unlikely(!__pyx_int_15)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  __pyx_int_17 = PyInt_FromLong(17); if (unlikely(!__pyx_int_17)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  __pyx_int_18 = PyInt_FromLong(18); if (unlikely(!__pyx_int_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  __pyx_int_0x10000 = PyInt_FromLong(0x10000); if (unlikely(!__pyx_int_0x10000)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  return 0;
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-#if PY_MAJOR_VERSION < 3
-PyMODINIT_FUNC initctabix(void); /*proto*/
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-PyMODINIT_FUNC PyInit_ctabix(void); /*proto*/
-PyMODINIT_FUNC PyInit_ctabix(void)
-#endif
-{
-  PyObject *__pyx_t_1 = NULL;
-  PyObject *__pyx_t_2 = NULL;
-  PyObject *__pyx_t_3 = NULL;
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-  __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  #ifdef __pyx_binding_PyCFunctionType_USED
-  if (__pyx_binding_PyCFunctionType_init() < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  #endif
-  /*--- Library function declarations ---*/
-  /*--- Threads initialization code ---*/
-  #if defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
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-  PyEval_InitThreads();
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-  /*--- Module creation code ---*/
-  #if PY_MAJOR_VERSION < 3
-  __pyx_m = Py_InitModule4(__Pyx_NAMESTR("ctabix"), __pyx_methods, 0, 0, PYTHON_API_VERSION);
-  #else
-  __pyx_m = PyModule_Create(&__pyx_moduledef);
-  #endif
-  if (!__pyx_m) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  #if PY_MAJOR_VERSION < 3
-  Py_INCREF(__pyx_m);
-  #endif
-  __pyx_b = PyImport_AddModule(__Pyx_NAMESTR(__Pyx_BUILTIN_MODULE_NAME));
-  if (!__pyx_b) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  if (__Pyx_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  /*--- Initialize various global constants etc. ---*/
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-  if (__pyx_module_is_main_ctabix) {
-    if (__Pyx_SetAttrString(__pyx_m, "__name__", __pyx_n_s____main__) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
-  }
-  /*--- Builtin init code ---*/
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-  /*--- Global init code ---*/
-  /*--- Function export code ---*/
-  /*--- Type init code ---*/
-  if (PyType_Ready(&__pyx_type_6ctabix_Tabixfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 8; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "Tabixfile", (PyObject *)&__pyx_type_6ctabix_Tabixfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 8; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_Tabixfile = &__pyx_type_6ctabix_Tabixfile;
-  if (PyType_Ready(&__pyx_type_6ctabix_Parser) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 264; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "Parser", (PyObject *)&__pyx_type_6ctabix_Parser) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 264; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_Parser = &__pyx_type_6ctabix_Parser;
-  if (PyType_Ready(&__pyx_type_6ctabix_TabixIterator) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 161; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_6ctabix_TabixIterator, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 161; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_6ctabix_13TabixIterator___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
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-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_6ctabix_13TabixIterator___next__;
-    }
-  }
-  if (__Pyx_SetAttrString(__pyx_m, "TabixIterator", (PyObject *)&__pyx_type_6ctabix_TabixIterator) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 161; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_TabixIterator = &__pyx_type_6ctabix_TabixIterator;
-  if (PyType_Ready(&__pyx_type_6ctabix_TabixHeaderIterator) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 216; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_6ctabix_TabixHeaderIterator, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 216; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_6ctabix_19TabixHeaderIterator___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_6ctabix_19TabixHeaderIterator___next__.doc = __pyx_doc_6ctabix_19TabixHeaderIterator___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_6ctabix_19TabixHeaderIterator___next__;
-    }
-  }
-  if (__Pyx_SetAttrString(__pyx_m, "TabixHeaderIterator", (PyObject *)&__pyx_type_6ctabix_TabixHeaderIterator) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 216; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_TabixHeaderIterator = &__pyx_type_6ctabix_TabixHeaderIterator;
-  __pyx_type_6ctabix_asTuple.tp_base = __pyx_ptype_6ctabix_Parser;
-  if (PyType_Ready(&__pyx_type_6ctabix_asTuple) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 267; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "asTuple", (PyObject *)&__pyx_type_6ctabix_asTuple) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 267; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_asTuple = &__pyx_type_6ctabix_asTuple;
-  __pyx_type_6ctabix_asGTF.tp_base = __pyx_ptype_6ctabix_Parser;
-  if (PyType_Ready(&__pyx_type_6ctabix_asGTF) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 277; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "asGTF", (PyObject *)&__pyx_type_6ctabix_asGTF) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 277; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_asGTF = &__pyx_type_6ctabix_asGTF;
-  __pyx_type_6ctabix_asBed.tp_base = __pyx_ptype_6ctabix_Parser;
-  if (PyType_Ready(&__pyx_type_6ctabix_asBed) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 285; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "asBed", (PyObject *)&__pyx_type_6ctabix_asBed) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 285; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_asBed = &__pyx_type_6ctabix_asBed;
-  __pyx_type_6ctabix_asVCF.tp_base = __pyx_ptype_6ctabix_Parser;
-  if (PyType_Ready(&__pyx_type_6ctabix_asVCF) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 293; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_SetAttrString(__pyx_m, "asVCF", (PyObject *)&__pyx_type_6ctabix_asVCF) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 293; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_asVCF = &__pyx_type_6ctabix_asVCF;
-  if (PyType_Ready(&__pyx_type_6ctabix_TabixIteratorParsed) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 304; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  {
-    PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_6ctabix_TabixIteratorParsed, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 304; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
-      __pyx_wrapperbase_6ctabix_19TabixIteratorParsed___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
-      __pyx_wrapperbase_6ctabix_19TabixIteratorParsed___next__.doc = __pyx_doc_6ctabix_19TabixIteratorParsed___next__;
-      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_6ctabix_19TabixIteratorParsed___next__;
-    }
-  }
-  if (__Pyx_SetAttrString(__pyx_m, "TabixIteratorParsed", (PyObject *)&__pyx_type_6ctabix_TabixIteratorParsed) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 304; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_6ctabix_TabixIteratorParsed = &__pyx_type_6ctabix_TabixIteratorParsed;
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-  __pyx_ptype_7cpython_4bool_bool = __Pyx_ImportType(__Pyx_BUILTIN_MODULE_NAME, "bool", sizeof(PyBoolObject), 0); if (unlikely(!__pyx_ptype_7cpython_4bool_bool)) {__pyx_filename = __pyx_f[1]; __pyx_lineno = 8; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_10TabProxies_TupleProxy = __Pyx_ImportType("TabProxies", "TupleProxy", sizeof(struct __pyx_obj_10TabProxies_TupleProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_TupleProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 42; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_TupleProxy->tp_dict, &__pyx_vtabptr_10TabProxies_TupleProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 42; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_10TabProxies_GTFProxy = __Pyx_ImportType("TabProxies", "GTFProxy", sizeof(struct __pyx_obj_10TabProxies_GTFProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_GTFProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_GTFProxy->tp_dict, &__pyx_vtabptr_10TabProxies_GTFProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_10TabProxies_NamedTupleProxy = __Pyx_ImportType("TabProxies", "NamedTupleProxy", sizeof(struct __pyx_obj_10TabProxies_NamedTupleProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_NamedTupleProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 77; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_NamedTupleProxy->tp_dict, &__pyx_vtabptr_10TabProxies_NamedTupleProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 77; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_10TabProxies_BedProxy = __Pyx_ImportType("TabProxies", "BedProxy", sizeof(struct __pyx_obj_10TabProxies_BedProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_BedProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 80; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_BedProxy->tp_dict, &__pyx_vtabptr_10TabProxies_BedProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 80; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __pyx_ptype_10TabProxies_VCFProxy = __Pyx_ImportType("TabProxies", "VCFProxy", sizeof(struct __pyx_obj_10TabProxies_VCFProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_VCFProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 91; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_VCFProxy->tp_dict, &__pyx_vtabptr_10TabProxies_VCFProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 91; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  /*--- Function import code ---*/
-  /*--- Execution code ---*/
-
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- * import tempfile, os, sys, types, itertools, struct, ctypes, gzip             # <<<<<<<<<<<<<<
- * from cpython cimport PyString_FromStringAndSize, PyString_AS_STRING
- * cimport TabProxies
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-  __Pyx_GOTREF(__pyx_t_1);
-  if (PyObject_SetAttr(__pyx_m, __pyx_n_s__tempfile, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 4; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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-  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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-  __pyx_t_2 = PyObject_GetAttr(__pyx_t_3, __pyx_n_s____next__); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  __pyx_t_3 = __Pyx_GetAttrString(__pyx_t_2, "__doc__"); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_kp_u_35), __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  __pyx_t_3 = PyObject_GetAttr(__pyx_m, __pyx_n_s__tabix_compress); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __pyx_t_2 = __Pyx_GetAttrString(__pyx_t_3, "__doc__"); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_kp_u_36), __pyx_t_2) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  __pyx_t_2 = PyObject_GetAttr(__pyx_m, __pyx_n_s__tabix_index); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_2);
-  __pyx_t_3 = __Pyx_GetAttrString(__pyx_t_2, "__doc__"); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_GOTREF(__pyx_t_3);
-  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
-  if (PyDict_SetItem(__pyx_t_1, ((PyObject *)__pyx_kp_u_37), __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
-  if (PyObject_SetAttr(__pyx_m, __pyx_n_s____test__, ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
-  __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
-
-  /* "/ifs/apps/apps/python-2.7.1/lib/python2.7/site-packages/Cython-0.13-py2.7-linux-x86_64.egg/Cython/Includes/cpython/type.pxd":2
- * 
- * cdef extern from "Python.h":             # <<<<<<<<<<<<<<
- *     # The C structure of the objects used to describe built-in types.
- * 
- */
-  goto __pyx_L0;
-  __pyx_L1_error:;
-  __Pyx_XDECREF(__pyx_t_1);
-  __Pyx_XDECREF(__pyx_t_2);
-  __Pyx_XDECREF(__pyx_t_3);
-  if (__pyx_m) {
-    __Pyx_AddTraceback("init ctabix");
-    Py_DECREF(__pyx_m); __pyx_m = 0;
-  } else if (!PyErr_Occurred()) {
-    PyErr_SetString(PyExc_ImportError, "init ctabix");
-  }
-  __pyx_L0:;
-  __Pyx_RefNannyFinishContext();
-  #if PY_MAJOR_VERSION < 3
-  return;
-  #else
-  return __pyx_m;
-  #endif
-}
-
-/* Runtime support code */
-
-static PyObject *__Pyx_GetName(PyObject *dict, PyObject *name) {
-    PyObject *result;
-    result = PyObject_GetAttr(dict, name);
-    if (!result)
-        PyErr_SetObject(PyExc_NameError, name);
-    return result;
-}
-
-static CYTHON_INLINE int __Pyx_CheckKeywordStrings(
-    PyObject *kwdict,
-    const char* function_name,
-    int kw_allowed)
-{
-    PyObject* key = 0;
-    Py_ssize_t pos = 0;
-    while (PyDict_Next(kwdict, &pos, &key, 0)) {
-        #if PY_MAJOR_VERSION < 3
-        if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key)))
-        #else
-        if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key)))
-        #endif
-            goto invalid_keyword_type;
-    }
-    if ((!kw_allowed) && unlikely(key))
-        goto invalid_keyword;
-    return 1;
-invalid_keyword_type:
-    PyErr_Format(PyExc_TypeError,
-        "%s() keywords must be strings", function_name);
-    return 0;
-invalid_keyword:
-    PyErr_Format(PyExc_TypeError,
-    #if PY_MAJOR_VERSION < 3
-        "%s() got an unexpected keyword argument '%s'",
-        function_name, PyString_AsString(key));
-    #else
-        "%s() got an unexpected keyword argument '%U'",
-        function_name, key);
-    #endif
-    return 0;
-}
-
-static void __Pyx_RaiseDoubleKeywordsError(
-    const char* func_name,
-    PyObject* kw_name)
-{
-    PyErr_Format(PyExc_TypeError,
-        #if PY_MAJOR_VERSION >= 3
-        "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
-        #else
-        "%s() got multiple values for keyword argument '%s'", func_name,
-        PyString_AS_STRING(kw_name));
-        #endif
-}
-
-static void __Pyx_RaiseArgtupleInvalid(
-    const char* func_name,
-    int exact,
-    Py_ssize_t num_min,
-    Py_ssize_t num_max,
-    Py_ssize_t num_found)
-{
-    Py_ssize_t num_expected;
-    const char *number, *more_or_less;
-
-    if (num_found < num_min) {
-        num_expected = num_min;
-        more_or_less = "at least";
-    } else {
-        num_expected = num_max;
-        more_or_less = "at most";
-    }
-    if (exact) {
-        more_or_less = "exactly";
-    }
-    number = (num_expected == 1) ? "" : "s";
-    PyErr_Format(PyExc_TypeError,
-        #if PY_VERSION_HEX < 0x02050000
-            "%s() takes %s %d positional argument%s (%d given)",
-        #else
-            "%s() takes %s %zd positional argument%s (%zd given)",
-        #endif
-        func_name, more_or_less, num_expected, number, num_found);
-}
-
-static int __Pyx_ParseOptionalKeywords(
-    PyObject *kwds,
-    PyObject **argnames[],
-    PyObject *kwds2,
-    PyObject *values[],
-    Py_ssize_t num_pos_args,
-    const char* function_name)
-{
-    PyObject *key = 0, *value = 0;
-    Py_ssize_t pos = 0;
-    PyObject*** name;
-    PyObject*** first_kw_arg = argnames + num_pos_args;
-
-    while (PyDict_Next(kwds, &pos, &key, &value)) {
-        name = first_kw_arg;
-        while (*name && (**name != key)) name++;
-        if (*name) {
-            values[name-argnames] = value;
-        } else {
-            #if PY_MAJOR_VERSION < 3
-            if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key))) {
-            #else
-            if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key))) {
-            #endif
-                goto invalid_keyword_type;
-            } else {
-                for (name = first_kw_arg; *name; name++) {
-                    #if PY_MAJOR_VERSION >= 3
-                    if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
-                        PyUnicode_Compare(**name, key) == 0) break;
-                    #else
-                    if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
-                        _PyString_Eq(**name, key)) break;
-                    #endif
-                }
-                if (*name) {
-                    values[name-argnames] = value;
-                } else {
-                    /* unexpected keyword found */
-                    for (name=argnames; name != first_kw_arg; name++) {
-                        if (**name == key) goto arg_passed_twice;
-                        #if PY_MAJOR_VERSION >= 3
-                        if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
-                            PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
-                        #else
-                        if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
-                            _PyString_Eq(**name, key)) goto arg_passed_twice;
-                        #endif
-                    }
-                    if (kwds2) {
-                        if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
-                    } else {
-                        goto invalid_keyword;
-                    }
-                }
-            }
-        }
-    }
-    return 0;
-arg_passed_twice:
-    __Pyx_RaiseDoubleKeywordsError(function_name, **name);
-    goto bad;
-invalid_keyword_type:
-    PyErr_Format(PyExc_TypeError,
-        "%s() keywords must be strings", function_name);
-    goto bad;
-invalid_keyword:
-    PyErr_Format(PyExc_TypeError,
-    #if PY_MAJOR_VERSION < 3
-        "%s() got an unexpected keyword argument '%s'",
-        function_name, PyString_AsString(key));
-    #else
-        "%s() got an unexpected keyword argument '%U'",
-        function_name, key);
-    #endif
-bad:
-    return -1;
-}
-
-
-static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
-    PyErr_Format(PyExc_ValueError,
-        #if PY_VERSION_HEX < 0x02050000
-                 "need more than %d value%s to unpack", (int)index,
-        #else
-                 "need more than %zd value%s to unpack", index,
-        #endif
-                 (index == 1) ? "" : "s");
-}
-
-static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
-    PyErr_Format(PyExc_ValueError,
-        #if PY_VERSION_HEX < 0x02050000
-            "too many values to unpack (expected %d)", (int)expected);
-        #else
-            "too many values to unpack (expected %zd)", expected);
-        #endif
-}
-
-static PyObject *__Pyx_UnpackItem(PyObject *iter, Py_ssize_t index) {
-    PyObject *item;
-    if (!(item = PyIter_Next(iter))) {
-        if (!PyErr_Occurred()) {
-            __Pyx_RaiseNeedMoreValuesError(index);
-        }
-    }
-    return item;
-}
-
-static int __Pyx_EndUnpack(PyObject *iter, Py_ssize_t expected) {
-    PyObject *item;
-    if ((item = PyIter_Next(iter))) {
-        Py_DECREF(item);
-        __Pyx_RaiseTooManyValuesError(expected);
-        return -1;
-    }
-    else if (!PyErr_Occurred())
-        return 0;
-    else
-        return -1;
-}
-
-static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
-    const char *name, int exact)
-{
-    if (!type) {
-        PyErr_Format(PyExc_SystemError, "Missing type object");
-        return 0;
-    }
-    if (none_allowed && obj == Py_None) return 1;
-    else if (exact) {
-        if (Py_TYPE(obj) == type) return 1;
-    }
-    else {
-        if (PyObject_TypeCheck(obj, type)) return 1;
-    }
-    PyErr_Format(PyExc_TypeError,
-        "Argument '%s' has incorrect type (expected %s, got %s)",
-        name, type->tp_name, Py_TYPE(obj)->tp_name);
-    return 0;
-}
-
-static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
-    PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
-}
-
-static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb) {
-    PyObject *local_type, *local_value, *local_tb;
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-    local_type = tstate->curexc_type;
-    local_value = tstate->curexc_value;
-    local_tb = tstate->curexc_traceback;
-    tstate->curexc_type = 0;
-    tstate->curexc_value = 0;
-    tstate->curexc_traceback = 0;
-    PyErr_NormalizeException(&local_type, &local_value, &local_tb);
-    if (unlikely(tstate->curexc_type))
-        goto bad;
-    #if PY_MAJOR_VERSION >= 3
-    if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
-        goto bad;
-    #endif
-    *type = local_type;
-    *value = local_value;
-    *tb = local_tb;
-    Py_INCREF(local_type);
-    Py_INCREF(local_value);
-    Py_INCREF(local_tb);
-    tmp_type = tstate->exc_type;
-    tmp_value = tstate->exc_value;
-    tmp_tb = tstate->exc_traceback;
-    tstate->exc_type = local_type;
-    tstate->exc_value = local_value;
-    tstate->exc_traceback = local_tb;
-    /* Make sure tstate is in a consistent state when we XDECREF
-       these objects (XDECREF may run arbitrary code). */
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-    return 0;
-bad:
-    *type = 0;
-    *value = 0;
-    *tb = 0;
-    Py_XDECREF(local_type);
-    Py_XDECREF(local_value);
-    Py_XDECREF(local_tb);
-    return -1;
-}
-
-
-static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
-    PyThreadState *tstate = PyThreadState_GET();
-    *type = tstate->exc_type;
-    *value = tstate->exc_value;
-    *tb = tstate->exc_traceback;
-    Py_XINCREF(*type);
-    Py_XINCREF(*value);
-    Py_XINCREF(*tb);
-}
-
-static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-    tmp_type = tstate->exc_type;
-    tmp_value = tstate->exc_value;
-    tmp_tb = tstate->exc_traceback;
-    tstate->exc_type = type;
-    tstate->exc_value = value;
-    tstate->exc_traceback = tb;
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-}
-
-static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
-    PyObject *py_import = 0;
-    PyObject *empty_list = 0;
-    PyObject *module = 0;
-    PyObject *global_dict = 0;
-    PyObject *empty_dict = 0;
-    PyObject *list;
-    py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
-    if (!py_import)
-        goto bad;
-    if (from_list)
-        list = from_list;
-    else {
-        empty_list = PyList_New(0);
-        if (!empty_list)
-            goto bad;
-        list = empty_list;
-    }
-    global_dict = PyModule_GetDict(__pyx_m);
-    if (!global_dict)
-        goto bad;
-    empty_dict = PyDict_New();
-    if (!empty_dict)
-        goto bad;
-    module = PyObject_CallFunctionObjArgs(py_import,
-        name, global_dict, empty_dict, list, NULL);
-bad:
-    Py_XDECREF(empty_list);
-    Py_XDECREF(py_import);
-    Py_XDECREF(empty_dict);
-    return module;
-}
-
-static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
-    PyObject *tmp_type, *tmp_value, *tmp_tb;
-    PyThreadState *tstate = PyThreadState_GET();
-
-    tmp_type = tstate->curexc_type;
-    tmp_value = tstate->curexc_value;
-    tmp_tb = tstate->curexc_traceback;
-    tstate->curexc_type = type;
-    tstate->curexc_value = value;
-    tstate->curexc_traceback = tb;
-    Py_XDECREF(tmp_type);
-    Py_XDECREF(tmp_value);
-    Py_XDECREF(tmp_tb);
-}
-
-static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
-    PyThreadState *tstate = PyThreadState_GET();
-    *type = tstate->curexc_type;
-    *value = tstate->curexc_value;
-    *tb = tstate->curexc_traceback;
-
-    tstate->curexc_type = 0;
-    tstate->curexc_value = 0;
-    tstate->curexc_traceback = 0;
-}
-
-
-#if PY_MAJOR_VERSION < 3
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
-    Py_XINCREF(type);
-    Py_XINCREF(value);
-    Py_XINCREF(tb);
-    /* First, check the traceback argument, replacing None with NULL. */
-    if (tb == Py_None) {
-        Py_DECREF(tb);
-        tb = 0;
-    }
-    else if (tb != NULL && !PyTraceBack_Check(tb)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: arg 3 must be a traceback or None");
-        goto raise_error;
-    }
-    /* Next, replace a missing value with None */
-    if (value == NULL) {
-        value = Py_None;
-        Py_INCREF(value);
-    }
-    #if PY_VERSION_HEX < 0x02050000
-    if (!PyClass_Check(type))
-    #else
-    if (!PyType_Check(type))
-    #endif
-    {
-        /* Raising an instance.  The value should be a dummy. */
-        if (value != Py_None) {
-            PyErr_SetString(PyExc_TypeError,
-                "instance exception may not have a separate value");
-            goto raise_error;
-        }
-        /* Normalize to raise <class>, <instance> */
-        Py_DECREF(value);
-        value = type;
-        #if PY_VERSION_HEX < 0x02050000
-            if (PyInstance_Check(type)) {
-                type = (PyObject*) ((PyInstanceObject*)type)->in_class;
-                Py_INCREF(type);
-            }
-            else {
-                type = 0;
-                PyErr_SetString(PyExc_TypeError,
-                    "raise: exception must be an old-style class or instance");
-                goto raise_error;
-            }
-        #else
-            type = (PyObject*) Py_TYPE(type);
-            Py_INCREF(type);
-            if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
-                PyErr_SetString(PyExc_TypeError,
-                    "raise: exception class must be a subclass of BaseException");
-                goto raise_error;
-            }
-        #endif
-    }
-
-    __Pyx_ErrRestore(type, value, tb);
-    return;
-raise_error:
-    Py_XDECREF(value);
-    Py_XDECREF(type);
-    Py_XDECREF(tb);
-    return;
-}
-
-#else /* Python 3+ */
-
-static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
-    if (tb == Py_None) {
-        tb = 0;
-    } else if (tb && !PyTraceBack_Check(tb)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: arg 3 must be a traceback or None");
-        goto bad;
-    }
-    if (value == Py_None)
-        value = 0;
-
-    if (PyExceptionInstance_Check(type)) {
-        if (value) {
-            PyErr_SetString(PyExc_TypeError,
-                "instance exception may not have a separate value");
-            goto bad;
-        }
-        value = type;
-        type = (PyObject*) Py_TYPE(value);
-    } else if (!PyExceptionClass_Check(type)) {
-        PyErr_SetString(PyExc_TypeError,
-            "raise: exception class must be a subclass of BaseException");
-        goto bad;
-    }
-
-    PyErr_SetObject(type, value);
-
-    if (tb) {
-        PyThreadState *tstate = PyThreadState_GET();
-        PyObject* tmp_tb = tstate->curexc_traceback;
-        if (tb != tmp_tb) {
-            Py_INCREF(tb);
-            tstate->curexc_traceback = tb;
-            Py_XDECREF(tmp_tb);
-        }
-    }
-
-bad:
-    return;
-}
-#endif
-
-static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject* x) {
-    const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
-    const int is_unsigned = const_zero < neg_one;
-    if (sizeof(int32_t) == sizeof(char)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedChar(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedChar(x);
-    } else if (sizeof(int32_t) == sizeof(short)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedShort(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedShort(x);
-    } else if (sizeof(int32_t) == sizeof(int)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedInt(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedInt(x);
-    } else if (sizeof(int32_t) == sizeof(long)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedLong(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedLong(x);
-    } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
-        if (is_unsigned)
-            return (int32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
-        else
-            return (int32_t)__Pyx_PyInt_AsSignedLongLong(x);
-    }  else {
-        int32_t val;
-        PyObject *v = __Pyx_PyNumber_Int(x);
-        #if PY_VERSION_HEX < 0x03000000
-        if (likely(v) && !PyLong_Check(v)) {
-            PyObject *tmp = v;
-            v = PyNumber_Long(tmp);
-            Py_DECREF(tmp);
-        }
-        #endif
-        if (likely(v)) {
-            int one = 1; int is_little = (int)*(unsigned char *)&one;
-            unsigned char *bytes = (unsigned char *)&val;
-            int ret = _PyLong_AsByteArray((PyLongObject *)v,
-                                          bytes, sizeof(val),
-                                          is_little, !is_unsigned);
-            Py_DECREF(v);
-            if (likely(!ret))
-                return val;
-        }
-        return (int32_t)-1;
-    }
-}
-
-static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
-    const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned char" :
-                    "value too large to convert to unsigned char");
-            }
-            return (unsigned char)-1;
-        }
-        return (unsigned char)val;
-    }
-    return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
-    const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned short" :
-                    "value too large to convert to unsigned short");
-            }
-            return (unsigned short)-1;
-        }
-        return (unsigned short)val;
-    }
-    return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
-    const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(unsigned int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(unsigned int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to unsigned int" :
-                    "value too large to convert to unsigned int");
-            }
-            return (unsigned int)-1;
-        }
-        return (unsigned int)val;
-    }
-    return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
-}
-
-static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
-    const char neg_one = (char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to char" :
-                    "value too large to convert to char");
-            }
-            return (char)-1;
-        }
-        return (char)val;
-    }
-    return (char)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
-    const short neg_one = (short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to short" :
-                    "value too large to convert to short");
-            }
-            return (short)-1;
-        }
-        return (short)val;
-    }
-    return (short)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
-    const int neg_one = (int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to int" :
-                    "value too large to convert to int");
-            }
-            return (int)-1;
-        }
-        return (int)val;
-    }
-    return (int)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
-    const signed char neg_one = (signed char)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed char) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed char)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed char" :
-                    "value too large to convert to signed char");
-            }
-            return (signed char)-1;
-        }
-        return (signed char)val;
-    }
-    return (signed char)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
-    const signed short neg_one = (signed short)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed short) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed short)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed short" :
-                    "value too large to convert to signed short");
-            }
-            return (signed short)-1;
-        }
-        return (signed short)val;
-    }
-    return (signed short)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
-    const signed int neg_one = (signed int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(signed int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(signed int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to signed int" :
-                    "value too large to convert to signed int");
-            }
-            return (signed int)-1;
-        }
-        return (signed int)val;
-    }
-    return (signed int)__Pyx_PyInt_AsSignedLong(x);
-}
-
-static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
-    const int neg_one = (int)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-    if (sizeof(int) < sizeof(long)) {
-        long val = __Pyx_PyInt_AsLong(x);
-        if (unlikely(val != (long)(int)val)) {
-            if (!unlikely(val == -1 && PyErr_Occurred())) {
-                PyErr_SetString(PyExc_OverflowError,
-                    (is_unsigned && unlikely(val < 0)) ?
-                    "can't convert negative value to int" :
-                    "value too large to convert to int");
-            }
-            return (int)-1;
-        }
-        return (int)val;
-    }
-    return (int)__Pyx_PyInt_AsLong(x);
-}
-
-static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
-    const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to unsigned long");
-            return (unsigned long)-1;
-        }
-        return (unsigned long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to unsigned long");
-                return (unsigned long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        unsigned long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (unsigned long)-1;
-        val = __Pyx_PyInt_AsUnsignedLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
-    const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to unsigned PY_LONG_LONG");
-            return (unsigned PY_LONG_LONG)-1;
-        }
-        return (unsigned PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to unsigned PY_LONG_LONG");
-                return (unsigned PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        unsigned PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (unsigned PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
-    const long neg_one = (long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to long");
-            return (long)-1;
-        }
-        return (long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to long");
-                return (long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (long)-1;
-        val = __Pyx_PyInt_AsLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
-    const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to PY_LONG_LONG");
-            return (PY_LONG_LONG)-1;
-        }
-        return (PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to PY_LONG_LONG");
-                return (PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
-    const signed long neg_one = (signed long)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to signed long");
-            return (signed long)-1;
-        }
-        return (signed long)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to signed long");
-                return (signed long)-1;
-            }
-            return PyLong_AsUnsignedLong(x);
-        } else {
-            return PyLong_AsLong(x);
-        }
-    } else {
-        signed long val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (signed long)-1;
-        val = __Pyx_PyInt_AsSignedLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
-    const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
-    const int is_unsigned = neg_one > const_zero;
-#if PY_VERSION_HEX < 0x03000000
-    if (likely(PyInt_Check(x))) {
-        long val = PyInt_AS_LONG(x);
-        if (is_unsigned && unlikely(val < 0)) {
-            PyErr_SetString(PyExc_OverflowError,
-                            "can't convert negative value to signed PY_LONG_LONG");
-            return (signed PY_LONG_LONG)-1;
-        }
-        return (signed PY_LONG_LONG)val;
-    } else
-#endif
-    if (likely(PyLong_Check(x))) {
-        if (is_unsigned) {
-            if (unlikely(Py_SIZE(x) < 0)) {
-                PyErr_SetString(PyExc_OverflowError,
-                                "can't convert negative value to signed PY_LONG_LONG");
-                return (signed PY_LONG_LONG)-1;
-            }
-            return PyLong_AsUnsignedLongLong(x);
-        } else {
-            return PyLong_AsLongLong(x);
-        }
-    } else {
-        signed PY_LONG_LONG val;
-        PyObject *tmp = __Pyx_PyNumber_Int(x);
-        if (!tmp) return (signed PY_LONG_LONG)-1;
-        val = __Pyx_PyInt_AsSignedLongLong(tmp);
-        Py_DECREF(tmp);
-        return val;
-    }
-}
-
-#ifndef __PYX_HAVE_RT_ImportType
-#define __PYX_HAVE_RT_ImportType
-static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
-    long size, int strict)
-{
-    PyObject *py_module = 0;
-    PyObject *result = 0;
-    PyObject *py_name = 0;
-    char warning[200];
-
-    py_module = __Pyx_ImportModule(module_name);
-    if (!py_module)
-        goto bad;
-    #if PY_MAJOR_VERSION < 3
-    py_name = PyString_FromString(class_name);
-    #else
-    py_name = PyUnicode_FromString(class_name);
-    #endif
-    if (!py_name)
-        goto bad;
-    result = PyObject_GetAttr(py_module, py_name);
-    Py_DECREF(py_name);
-    py_name = 0;
-    Py_DECREF(py_module);
-    py_module = 0;
-    if (!result)
-        goto bad;
-    if (!PyType_Check(result)) {
-        PyErr_Format(PyExc_TypeError, 
-            "%s.%s is not a type object",
-            module_name, class_name);
-        goto bad;
-    }
-    if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
-        PyOS_snprintf(warning, sizeof(warning), 
-            "%s.%s size changed, may indicate binary incompatibility",
-            module_name, class_name);
-        #if PY_VERSION_HEX < 0x02050000
-        PyErr_Warn(NULL, warning);
-        #else
-        PyErr_WarnEx(NULL, warning, 0);
-        #endif
-    }
-    else if (((PyTypeObject *)result)->tp_basicsize != size) {
-        PyErr_Format(PyExc_ValueError, 
-            "%s.%s has the wrong size, try recompiling",
-            module_name, class_name);
-        goto bad;
-    }
-    return (PyTypeObject *)result;
-bad:
-    Py_XDECREF(py_module);
-    Py_XDECREF(result);
-    return 0;
-}
-#endif
-
-#ifndef __PYX_HAVE_RT_ImportModule
-#define __PYX_HAVE_RT_ImportModule
-static PyObject *__Pyx_ImportModule(const char *name) {
-    PyObject *py_name = 0;
-    PyObject *py_module = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_name = PyString_FromString(name);
-    #else
-    py_name = PyUnicode_FromString(name);
-    #endif
-    if (!py_name)
-        goto bad;
-    py_module = PyImport_Import(py_name);
-    Py_DECREF(py_name);
-    return py_module;
-bad:
-    Py_XDECREF(py_name);
-    return 0;
-}
-#endif
-
-static int __Pyx_GetVtable(PyObject *dict, void *vtabptr) {
-    PyObject *ob = PyMapping_GetItemString(dict, (char *)"__pyx_vtable__");
-    if (!ob)
-        goto bad;
-#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
-    *(void **)vtabptr = PyCapsule_GetPointer(ob, 0);
-#else
-    *(void **)vtabptr = PyCObject_AsVoidPtr(ob);
-#endif
-    if (!*(void **)vtabptr)
-        goto bad;
-    Py_DECREF(ob);
-    return 0;
-bad:
-    Py_XDECREF(ob);
-    return -1;
-}
-
-#include "compile.h"
-#include "frameobject.h"
-#include "traceback.h"
-
-static void __Pyx_AddTraceback(const char *funcname) {
-    PyObject *py_srcfile = 0;
-    PyObject *py_funcname = 0;
-    PyObject *py_globals = 0;
-    PyCodeObject *py_code = 0;
-    PyFrameObject *py_frame = 0;
-
-    #if PY_MAJOR_VERSION < 3
-    py_srcfile = PyString_FromString(__pyx_filename);
-    #else
-    py_srcfile = PyUnicode_FromString(__pyx_filename);
-    #endif
-    if (!py_srcfile) goto bad;
-    if (__pyx_clineno) {
-        #if PY_MAJOR_VERSION < 3
-        py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
-        #else
-        py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
-        #endif
-    }
-    else {
-        #if PY_MAJOR_VERSION < 3
-        py_funcname = PyString_FromString(funcname);
-        #else
-        py_funcname = PyUnicode_FromString(funcname);
-        #endif
-    }
-    if (!py_funcname) goto bad;
-    py_globals = PyModule_GetDict(__pyx_m);
-    if (!py_globals) goto bad;
-    py_code = PyCode_New(
-        0,            /*int argcount,*/
-        #if PY_MAJOR_VERSION >= 3
-        0,            /*int kwonlyargcount,*/
-        #endif
-        0,            /*int nlocals,*/
-        0,            /*int stacksize,*/
-        0,            /*int flags,*/
-        __pyx_empty_bytes, /*PyObject *code,*/
-        __pyx_empty_tuple,  /*PyObject *consts,*/
-        __pyx_empty_tuple,  /*PyObject *names,*/
-        __pyx_empty_tuple,  /*PyObject *varnames,*/
-        __pyx_empty_tuple,  /*PyObject *freevars,*/
-        __pyx_empty_tuple,  /*PyObject *cellvars,*/
-        py_srcfile,   /*PyObject *filename,*/
-        py_funcname,  /*PyObject *name,*/
-        __pyx_lineno,   /*int firstlineno,*/
-        __pyx_empty_bytes  /*PyObject *lnotab*/
-    );
-    if (!py_code) goto bad;
-    py_frame = PyFrame_New(
-        PyThreadState_GET(), /*PyThreadState *tstate,*/
-        py_code,             /*PyCodeObject *code,*/
-        py_globals,          /*PyObject *globals,*/
-        0                    /*PyObject *locals*/
-    );
-    if (!py_frame) goto bad;
-    py_frame->f_lineno = __pyx_lineno;
-    PyTraceBack_Here(py_frame);
-bad:
-    Py_XDECREF(py_srcfile);
-    Py_XDECREF(py_funcname);
-    Py_XDECREF(py_code);
-    Py_XDECREF(py_frame);
-}
-
-static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
-    while (t->p) {
-        #if PY_MAJOR_VERSION < 3
-        if (t->is_unicode) {
-            *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
-        } else if (t->intern) {
-            *t->p = PyString_InternFromString(t->s);
-        } else {
-            *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
-        }
-        #else  /* Python 3+ has unicode identifiers */
-        if (t->is_unicode | t->is_str) {
-            if (t->intern) {
-                *t->p = PyUnicode_InternFromString(t->s);
-            } else if (t->encoding) {
-                *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
-            } else {
-                *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
-            }
-        } else {
-            *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
-        }
-        #endif
-        if (!*t->p)
-            return -1;
-        ++t;
-    }
-    return 0;
-}
-
-/* Type Conversion Functions */
-
-static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
-   int is_true = x == Py_True;
-   if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
-   else return PyObject_IsTrue(x);
-}
-
-static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
-  PyNumberMethods *m;
-  const char *name = NULL;
-  PyObject *res = NULL;
-#if PY_VERSION_HEX < 0x03000000
-  if (PyInt_Check(x) || PyLong_Check(x))
-#else
-  if (PyLong_Check(x))
-#endif
-    return Py_INCREF(x), x;
-  m = Py_TYPE(x)->tp_as_number;
-#if PY_VERSION_HEX < 0x03000000
-  if (m && m->nb_int) {
-    name = "int";
-    res = PyNumber_Int(x);
-  }
-  else if (m && m->nb_long) {
-    name = "long";
-    res = PyNumber_Long(x);
-  }
-#else
-  if (m && m->nb_int) {
-    name = "int";
-    res = PyNumber_Long(x);
-  }
-#endif
-  if (res) {
-#if PY_VERSION_HEX < 0x03000000
-    if (!PyInt_Check(res) && !PyLong_Check(res)) {
-#else
-    if (!PyLong_Check(res)) {
-#endif
-      PyErr_Format(PyExc_TypeError,
-                   "__%s__ returned non-%s (type %.200s)",
-                   name, name, Py_TYPE(res)->tp_name);
-      Py_DECREF(res);
-      return NULL;
-    }
-  }
-  else if (!PyErr_Occurred()) {
-    PyErr_SetString(PyExc_TypeError,
-                    "an integer is required");
-  }
-  return res;
-}
-
-static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
-  Py_ssize_t ival;
-  PyObject* x = PyNumber_Index(b);
-  if (!x) return -1;
-  ival = PyInt_AsSsize_t(x);
-  Py_DECREF(x);
-  return ival;
-}
-
-static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
-#if PY_VERSION_HEX < 0x02050000
-   if (ival <= LONG_MAX)
-       return PyInt_FromLong((long)ival);
-   else {
-       unsigned char *bytes = (unsigned char *) &ival;
-       int one = 1; int little = (int)*(unsigned char*)&one;
-       return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
-   }
-#else
-   return PyInt_FromSize_t(ival);
-#endif
-}
-
-static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
-   unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
-   if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
-       return (size_t)-1;
-   } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
-       PyErr_SetString(PyExc_OverflowError,
-                       "value too large to convert to size_t");
-       return (size_t)-1;
-   }
-   return (size_t)val;
-}
-
-
-#endif /* Py_PYTHON_H */