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A substantial biological challenge is to understand the regulation
and execution of developmental decisions that lead from multipotential,
undifferentiated precursor cells to their specialized differential products.
In the Wold lab at the California Institute of Technology, we are interested in several interrelated aspects of this
problem, and we also work to develop new methods for studying it. The
particular cell lineage problem we study begins with the specification
of mesoderm in early development and continues to the final differentiation
of skeletal muscle or cardiac muscle in the fully developed animal.
To study this process we use the mouse as our experimental system.
Molecular-level
analyses use cell culture model systems and transgenic mice. These projects include studies of in vitro and in vivo protein-DNA interactions
and of factors
that amplify or suppress
expression activity. Computational approaches involve the
development of algorithms for use in large-scale gene
expression analysis and the construction of a simulator
framework for regulation in muscle development.
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