PC-19 p<0.000010 High/Low PC-19 Value ProbeId Name Aliases LocusLink Description Function Protein_Families high 8.99283259125 209351_at KRT14 CK14;EBS3;EBS4;K14;KRT14 3861 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280) 14-3-3 protein (IPR000308);Intermediate filament protein (IPR001664);Keratin, type I (IPR002957);Tachykinin/Neurokinin (IPR002040) high 6.83822087762 209309_at AZGP1 AZGP1;ZA2G;ZAG 563 alpha-2-glycoprotein 1, zinc cell adhesion (GO:0007155);fatty acid binding (GO:0005504);immune response (GO:0006955);lipid catabolism (GO:0016042);negative regulation of cell proliferation (GO:0008285);plasma glycoprotein (GO:0005211);protein carrier activity (GO:0008320);ribonuclease activity (GO:0004540) Immunoglobulin C-type (IPR003597);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006);Major histocompatibility complex protein, class I (IPR001039) high 6.57027501675 204734_at KRT15 CK15;K15;K1CO;KRT15 3866 keratin 15 structural constituent of cytoskeleton (GO:0005200) Intermediate filament protein (IPR001664);Keratin, type I (IPR002957) high 6.41760959449 200872_at S100A10 42C;ANX2L;ANX2LG;CAL1L;CLP11;Ca[1];GP11;P11;S100A10;p10 6281 S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) calcium ion binding (GO:0005509);receptor binding (GO:0005102);signal transduction (GO:0007165) Calcium-binding EF-hand (IPR002048);Calcium-binding protein, S-100/ICaBP type (IPR001751) high 6.1971675555 209301_at CA2 CA-II;CA2 760 carbonic anhydrase II carbonate dehydratase activity (GO:0004089);lyase activity (GO:0016829);one-carbon compound metabolism (GO:0006730);zinc ion binding (GO:0008270) Carbonic anhydrase, eukaryotic (IPR001148) high 6.02917309791 214063_s_at TF PRO1557;PRO2086 7018 transferrin ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) Bipartite nuclear localization signal (IPR001472);Peptidase S60, transferrin lactoferrin (IPR001156) high 6.02276938314 204379_s_at FGFR3 ACH;CEK2;FGFR3;HSFGFR3EX;JTK4 2261 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) ATP binding (GO:0005524);JAK-STAT cascade (GO:0007259);MAPKKK cascade (GO:0000165);cell growth (GO:0016049);fibroblast growth factor receptor activity (GO:0005007);fibroblast growth factor receptor signaling pathway (GO:0008543);oncogenesis (GO:0007048);protein amino acid phosphorylation (GO:0006468);protein-tyrosine kinase activity (GO:0004713);receptor activity (GO:0004872);skeletal development (GO:0001501);transferase activity (GO:0016740) Immunoglobulin C-2 type (IPR003598);Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006);Protein kinase (IPR000719);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) high 5.92751321726 205113_at NEF3 NEF3;NEFM;NF-M;NFM 4741 neurofilament 3 (150kDa medium) structural constituent of cytoskeleton (GO:0005200) Intermediate filament protein (IPR001664);Intermediate filament, DNA-binding region (IPR006821);Keratin, type I (IPR002957) high 5.87210186618 216620_s_at ARHGEF10 ARHGEF10;GEF10;KIAA0294 9639 Rho guanine nucleotide exchange factor (GEF) 10 None DH domain (IPR000219);Peptidase, eukaryotic cysteine peptidase active site (IPR000169) high 5.80798016722 209894_at LEPR LEPR;OBR;OBRGRP 3953 leptin receptor biological_process unknown (GO:0000004);cell surface receptor linked signal transduction (GO:0007166);development (GO:0007275);energy reserve metabolism (GO:0006112);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);molecular_function unknown (GO:0005554);transmembrane receptor activity (GO:0004888) Bipartite nuclear localization signal (IPR001472);Cytokine receptor, common beta/gamma chain (IPR002996);Fibronectin, type III (IPR003961);Fibronectin, type III-like fold (IPR008957);Immunoglobulin-like (IPR007110);Long hematopoietin receptor, gp130 family 2 (IPR003529);Short hematopoietin receptor, family 1 (IPR003531);Vacuolar protein sorting 55 (IPR007262) high 5.8033138288 215388_s_at HFL1 CFHL;FHR1;H36-1;HFL1 3078 H factor (complement)-like 1 plasma protein (GO:0005209) Sushi domain/SCR domain/CCP module (IPR000436) high 5.78222207263 201131_s_at CDH1 CDH1;CDHE;ECAD;LCAM;UVO 999 cadherin 1, type 1, E-cadherin (epithelial) calcium ion binding (GO:0005509);calcium-dependent cell adhesion molecule activity (GO:0008014);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);homophilic cell adhesion (GO:0007156);protein binding (GO:0005515);tumor suppressor (GO:0008181) Cadherin (IPR002126);Cadherin cytoplasmic region (IPR000233) high 5.73400521985 gnf1h01731_s_at gnf1h01731_s_at None None None None None high 5.71503542046 211719_x_at FN1 CIG;FINC;FN1;LETS;MSF 2335 fibronectin 1 acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611) Aldehyde dehydrogenase (IPR002086);Bipartite nuclear localization signal (IPR001472);EGF-like domain (IPR006209);Fibronectin, type I (IPR000083);Fibronectin, type III (IPR003961);Fibronectin, type III subdomain (IPR003962);Fibronectin, type III-like fold (IPR008957);Type II fibronectin collagen-binding domain (IPR000562) high 5.70711869682 203400_s_at TF PRO1557;PRO2086 7018 transferrin ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) Bipartite nuclear localization signal (IPR001472);Peptidase S60, transferrin lactoferrin (IPR001156) high 5.68243185839 206400_at LGALS7 GAL7;LGALS7;PIG1;TP53I1 3963 lectin, galactoside-binding, soluble, 7 (galectin 7) apoptosis (GO:0006915);cell adhesion (GO:0007155);cell growth and/or maintenance (GO:0008151);galactose binding (GO:0005534);galactose binding lectin (GO:0005531);heterophilic cell adhesion (GO:0007157);lectin (GO:0005530);sugar binding (GO:0005529) Concanavalin A-like lectin/glucanase (IPR008985);Galectin, galactose-binding lectin (IPR001079) high 5.63689330765 201820_at KRT5 CK5;EBS2;KRT5;KRT5A 3852 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) structural constituent of cytoskeleton (GO:0005200) AMP-dependent synthetase and ligase (IPR000873);Intermediate filament protein (IPR001664);Keratin, type I (IPR002957);Type II keratin (IPR003054) low -5.84096669665 gnf1h06672_at ZNF521 DKFZp564D0764;EHZF;Evi3;ZNF521 25925 zinc finger protein 521 nucleic acid binding (GO:0003676);zinc ion binding (GO:0008270) Zn-finger, C2H2 type (IPR007087) low -5.87456874347 207981_s_at ESRRG ERR3;ESRRG;NR3B3 2104 estrogen-related receptor gamma AF-2 domain binding (GO:0050682);DNA binding (GO:0003677);calmodulin binding (GO:0005516);development (GO:0007275);ligand-dependent nuclear receptor activity (GO:0004879);receptor activity (GO:0004872);steroid binding (GO:0005496);steroid hormone receptor activity (GO:0003707);transcription factor activity (GO:0003700);transcriptional activator activity (GO:0016563);translation regulator activity (GO:0045182) Ligand-binding domain of nuclear hormone receptor (IPR000536);Retinoic acid receptor (IPR003078);Retinoid X receptor (IPR000003);Steroid hormone receptor (IPR001723);Steroid nuclear receptor, ligand-binding (IPR008946);Vitamin D receptor (IPR000324);Zn-finger, C4-type steroid receptor (IPR001628) low -5.90584858105 gnf1h09155_s_at EIF2C2 AGO2;EIF2C2;MGC3183;Q10 27161 eukaryotic translation initiation factor 2C, 2 protein biosynthesis (GO:0006412);translation initiation factor activity (GO:0003743) Argonaute and Dicer protein, PAZ (IPR003100);Stem cell self-renewal protein Piwi (IPR003165) low -5.95591881466 213182_x_at CDKN1C BWCR;BWS;CDKN1C;KIP2;WBS;p57 1028 cyclin-dependent kinase inhibitor 1C (p57, Kip2) cell growth and/or maintenance (GO:0008151);cyclin-dependent protein kinase inhibitor activity (GO:0004861);negative regulation of cell proliferation (GO:0008285);nutrient reservoir activity (GO:0045735);oncogenesis (GO:0007048);regulation of cyclin dependent protein kinase activity (GO:0000079);tumor suppressor (GO:0008181) Bipartite nuclear localization signal (IPR001472);Cyclin-dependent kinase inhibitor (IPR003175);Glutelin (IPR000480);Proline-rich region (IPR000694) low -5.97808913916 208069_x_at GH1 GH-N;GH1;GHN 2688 growth hormone 1 hormone activity (GO:0005179);peptide hormone (GO:0005180);signal transduction (GO:0007165) Somatotropin hormone (IPR001400) low -6.02348898212 212092_at PEG10 Edr;HB-1;KIAA1051;MEF3L;PEG10 23089 paternally expressed 10 nucleic acid binding (GO:0003676) Retrotransposon gag protein (IPR005162);Zn-finger, CCHC type (IPR001878) low -6.17514916644 208341_x_at CSH2 CSB;CSH2 1443 chorionic somatomammotropin hormone 2 cell-cell signaling (GO:0007267);growth hormone receptor binding (GO:0005131);hormone activity (GO:0005179);pregnancy (GO:0007565);signal transduction (GO:0007165) Four-helical cytokine (IPR009079);Somatotropin hormone (IPR001400) low -6.20935379884 gnf1h01776_s_at MGA KIAA0518;MAD5;MGA;MXD5 23269 MAX gene associated transcription factor activity (GO:0003700) Basic helix-loop-helix dimerization domain bHLH (IPR001092);Transcription factor, T-box (IPR001699);p53-like transcription factor, DNA-binding (IPR008967) low -6.32328076496 215834_x_at SCARB1 CD36L1;CLA-1;CLA1;SCARB1;SR-BI;SRB1 949 scavenger receptor class B, member 1 apoptosis (GO:0006915);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);cholesterol metabolism (GO:0008203);receptor activity (GO:0004872);small molecule transport (GO:0006832);transporter activity (GO:0005215) Adhesion molecule CD36 (IPR005428);CD36 antigen (IPR002159) low -6.33517839047 204068_at STK3 KRS1;MST2;STK3 6788 serine/threonine kinase 3 (STE20 homolog, yeast) ATP binding (GO:0005524);apoptosis (GO:0006915);cAMP-dependent protein kinase activity (GO:0004691);protein amino acid phosphorylation (GO:0006468);protein kinase CK2 activity (GO:0004682);protein kinase activity (GO:0004672);protein serine/threonine kinase activity (GO:0004674);signal transduction (GO:0007165);transferase activity (GO:0016740) Bipartite nuclear localization signal (IPR001472);Protein kinase (IPR000719);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) low -6.42388995176 209560_s_at DLK1 DLK1;FA1;PREF1;Pref-1;ZOG;pG2 8788 delta-like 1 homolog (Drosophila) biological_process unknown (GO:0000004);calcium ion binding (GO:0005509);development (GO:0007275);molecular_function unknown (GO:0005554);structural molecule activity (GO:0005198) Concanavalin A-like lectin/glucanase (IPR008985);EGF-like calcium-binding (IPR001881);EGF-like domain (IPR006209);EGF-like domain, subtype 2 (IPR000742);Laminin-type EGF-like domain (IPR002049);Type I EGF (IPR006210);Type II EGF-like signature (IPR001438) low -6.53640734467 211959_at IGFBP5 IBP5;IGFBP5 3488 insulin-like growth factor binding protein 5 cell growth and/or maintenance (GO:0008151);insulin-like growth factor binding (GO:0005520);regulation of cell growth (GO:0001558);signal transduction (GO:0007165) Bipartite nuclear localization signal (IPR001472);Growth factor, receptor (IPR009030);Insulin-like growth factor-binding protein, IGFBP (IPR000867);Thyroglobulin type-1 (IPR000716) low -6.54128912563 213714_at CACNB2 CACNB2;CACNLB2;MYSB 783 calcium channel, voltage-dependent, beta 2 subunit calcium ion transport (GO:0006816);ion transport (GO:0006811);small molecule transport (GO:0006832);transport (GO:0006810);voltage-gated calcium channel activity (GO:0005245) Dihydropyridine sensitive L-type calcium channel, beta subunit (IPR000584);Guanylate kinase/L-type calcium channel region (IPR008145);L-type calcium channel beta 2 subunit (IPR005444);SH3 (IPR001452) low -6.55809493339 212095_s_at MTUS1 ATIP1;DKFZp586D1519;FLJ14295;KIAA1288;MP44;MTSG1;MTUS1 57509 mitochondrial tumor suppressor 1 receptor activity (GO:0004872) None low -6.58250859481 219424_at EBI3 EBI3 10148 Epstein-Barr virus induced gene 3 cellular defense response (GO:0006968);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);humoral immune response (GO:0006959);receptor activity (GO:0004872) Cytokine receptor, common beta/gamma chain (IPR002996);Fibronectin, type III (IPR003961);Fibronectin, type III-like fold (IPR008957);Long hematopoietin receptor, soluble alpha chain (IPR003530) low -6.85926939872 gnf1h06525_at H19 ASM;ASM1;D11S813E;H19;MGC4485 283120 H19, imprinted maternally expressed untranslated mRNA None None low -7.12639316112 209243_s_at PEG3 KIAA0287;PEG3;PW1;ZIM2 5178 paternally expressed 3 DNA binding (GO:0003677);signal transducer activity (GO:0004871);transcription factor activity (GO:0003700);zinc ion binding (GO:0008270) KRAB box (IPR001909);Transcriptional regulator SCAN (IPR003309);Zn-finger, C2H2 type (IPR007087) low -7.89503801415 201744_s_at LUM LDC;LUM;SLRR2D 4060 lumican collagen binding (GO:0005518);collagen fibril organization (GO:0030199);extracellular matrix glycoprotein (GO:0005207);extracellular matrix structural constituent (GO:0005201);proteoglycan (GO:0005203);visual perception (GO:0007601) Cysteine-rich flanking region, N-terminal (IPR000372) low -10.1652303418 213792_s_at INSR INSR 3643 insulin receptor ATP binding (GO:0005524);carbohydrate metabolism (GO:0005975);cell growth and/or maintenance (GO:0008151);development (GO:0007275);energy pathways (GO:0006091);epidermal growth factor receptor activity (GO:0005006);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);receptor activity (GO:0004872);receptor signaling protein tyrosine kinase activity (GO:0004716);signal transducer activity (GO:0004871);signal transduction (GO:0007165);transferase activity (GO:0016740);transmembrane receptor protein tyrosine kinase activity (GO:0004714);transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169);transmembrane receptor protein tyrosine kinase signaling protein activity (GO:0005066) Epidermal growth-factor receptor (EGFR), L domain (IPR000494);Fibronectin, type III (IPR003961);Furin-like cysteine rich region (IPR006211);Growth factor, receptor (IPR009030);Protein kinase (IPR000719);Receptor tyrosine kinase, class II (IPR002011);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245)