PC-25 p<0.000010 High/Low PC-25 Value ProbeId Name Aliases LocusLink Description Function Protein_Families high 8.04196019255 210342_s_at TPO MSA;TPO;TPX 7173 thyroid peroxidase calcium ion binding (GO:0005509);iodide peroxidase activity (GO:0004447);oxidoreductase activity (GO:0016491);peroxidase activity (GO:0004601);response to oxidative stress (GO:0006979);thyroid hormone generation (GO:0006590) Animal haem peroxidase (IPR002007);EGF-like calcium-binding (IPR001881);EGF-like domain (IPR006209);Haem peroxidase, plant/fungal/bacterial (IPR002016);Sushi domain/SCR domain/CCP module (IPR000436) high 7.88827518051 203673_at TG None 7038 thyroglobulin carboxylic ester hydrolase activity (GO:0016789);hormone activity (GO:0005179);signal transduction (GO:0007165);thyroid hormone generation (GO:0006590) Carboxylesterase, type B (IPR002018);Thyroglobulin type-1 (IPR000716) high 7.48247535375 203953_s_at CLDN3 CLDN3;CPE-R2;CPETR2;HRVP1;RVP1 1365 claudin 3 structural molecule activity (GO:0005198);transmembrane receptor activity (GO:0004888) Claudin region (IPR006188);Claudin tight junction protein (IPR006187);Claudin-14 (IPR003556);Claudin-3 (IPR003549);PMP-22/EMP/MP20 and claudin (IPR004031) high 7.41612119743 204487_s_at KCNQ1 ATFB1;KCNA8;KCNA9;KCNQ1;KVLQT1;Kv1.9;Kv7.1;LQT;LQT1;RWS;WRS 3784 potassium voltage-gated channel, KQT-like subfamily, member 1 cation transport (GO:0006812);delayed rectifier potassium channel activity (GO:0005251);ion channel activity (GO:0005216);ion transport (GO:0006811);muscle contraction (GO:0006936);perception of sound (GO:0007605);potassium ion transport (GO:0006813);regulation of heart rate (GO:0008016);voltage-gated potassium channel activity (GO:0005249) Cation channel, non-ligand gated (IPR005820);Ion transport protein (IPR005821);K+ channel, pore region (IPR001622);KCNQ voltage-gated potassium channel (IPR003937);Proline-rich region (IPR000694);Voltage-dependent potassium channel (IPR003091) high 7.30267873138 215443_at TSHR LGR3;TSHR 7253 thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 7.20121506807 209552_at PAX8 PAX8 7849 paired box gene 8 DNA binding (GO:0003677);biological_process unknown (GO:0000004);cell differentiation (GO:0030154);development (GO:0007275);embryogenesis and morphogenesis (GO:0007345);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);morphogenesis (GO:0009653);thyroid-stimulating hormone receptor activity (GO:0004996);transcription (GO:0006350);transcription factor activity (GO:0003700) Homeodomain-like (IPR009057);Paired box protein, N-terminal (IPR001523);Proline-rich region (IPR000694) high 6.99172757367 210055_at TSHR LGR3;TSHR 7253 thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 6.77338711523 gnf1h09294_s_at HBG1 HBG1;HBGA;HBGR 3047 hemoglobin, gamma A oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) Beta haemoglobin (IPR002337);Globin (IPR000971);Globin-like (IPR009050) high 6.7143615546 gnf1h09872_at gnf1h09872_at None None None None None high 6.61678121135 214528_s_at PAX8 PAX8 7849 paired box gene 8 DNA binding (GO:0003677);biological_process unknown (GO:0000004);cell differentiation (GO:0030154);development (GO:0007275);embryogenesis and morphogenesis (GO:0007345);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);morphogenesis (GO:0009653);thyroid-stimulating hormone receptor activity (GO:0004996);transcription (GO:0006350);transcription factor activity (GO:0003700) Homeodomain-like (IPR009057);Paired box protein, N-terminal (IPR001523);Proline-rich region (IPR000694) high 6.53779701936 gnf1h01161_at SLC26A7 SLC26A7;SUT2 115111 solute carrier family 26, member 7 sulfate porter activity (GO:0008271);sulfate transport (GO:0008272) Sulfate transporter/antisigma-factor antagonist STAS (IPR002645);Sulphate transporter (IPR001902) high 6.32621933938 206977_at PTH PTH 5741 parathyroid hormone G-protein coupled receptor protein signaling pathway (GO:0007186);cAMP generating peptide activity (GO:0008492);cAMP metabolism (GO:0046058);calcium ion homeostasis (GO:0006874);cell-cell signaling (GO:0007267);hormone activity (GO:0005179);peptide hormone (GO:0005180);skeletal development (GO:0001501) Parathyroid hormone (IPR001415);Parathyroid hormone subtype (IPR003625) high 6.30998386372 203954_x_at CLDN3 CLDN3;CPE-R2;CPETR2;HRVP1;RVP1 1365 claudin 3 structural molecule activity (GO:0005198);transmembrane receptor activity (GO:0004888) Claudin region (IPR006188);Claudin tight junction protein (IPR006187);Claudin-14 (IPR003556);Claudin-3 (IPR003549);PMP-22/EMP/MP20 and claudin (IPR004031) high 6.28253885058 203240_at FCGBP FC(GAMMA)BP;FCGBP 8857 Fc fragment of IgG binding protein immune response (GO:0006955);protein binding (GO:0005515) Cysteine-rich TIL region (IPR002919);Follistatin-like, N-terminal (IPR003645);von Willebrand factor, type C (IPR001007);von Willebrand factor, type D (IPR001846) high 6.09941156094 266_s_at CD24 CD24;CD24A 934 CD24 antigen (small cell lung carcinoma cluster 4 antigen) humoral immune response (GO:0006959) None high 6.06898368835 201340_s_at ENC1 CCL28;ENC-1;ENC1;NRPB;PIG10;TP53I10 8507 ectodermal-neural cortex (with BTB-like domain) actin binding (GO:0003779);development (GO:0007275);neurogenesis (GO:0007399);protein binding (GO:0005515) BTB/POZ (IPR000210);Peptidase, eukaryotic cysteine peptidase active site (IPR000169) low -4.47828729201 216894_x_at CDKN1C BWCR;BWS;CDKN1C;KIP2;WBS;p57 1028 cyclin-dependent kinase inhibitor 1C (p57, Kip2) cell growth and/or maintenance (GO:0008151);cyclin-dependent protein kinase inhibitor activity (GO:0004861);negative regulation of cell proliferation (GO:0008285);nutrient reservoir activity (GO:0045735);oncogenesis (GO:0007048);regulation of cyclin dependent protein kinase activity (GO:0000079);tumor suppressor (GO:0008181) Bipartite nuclear localization signal (IPR001472);Cyclin-dependent kinase inhibitor (IPR003175);Glutelin (IPR000480);Proline-rich region (IPR000694) low -4.52599849805 gnf1h00517_s_at KRTAP4-12 KAP4.12;KRTAP4-12;KRTAP4.12 83755 keratin associated protein 4-12 None Antifreeze protein, type I (IPR000104);Keratin, high sulfur B2 protein (IPR002494);Proline-rich region (IPR000694) low -4.53284780965 204351_at S100P S100P 6286 S100 calcium binding protein P calcium ion binding (GO:0005509);protein binding (GO:0005515) Calcium-binding EF-hand (IPR002048);Calcium-binding protein, S-100/ICaBP type (IPR001751) low -4.58619447068 gnf1h08069_s_at ENPP2 ATX;ENPP2;LysoPLD;PD-IALPHA;PDNP2 5168 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) G-protein coupled receptor protein signaling pathway (GO:0007186);cell motility (GO:0006928);chemotaxis (GO:0006935);endonuclease activity (GO:0004519);hydrolase activity (GO:0016787);nucleic acid binding (GO:0003676);nucleotide diphosphatase activity (GO:0004551);nucleotide metabolism (GO:0009117);phosphate metabolism (GO:0006796);phosphodiesterase I activity (GO:0004528);transcription factor binding (GO:0008134) Bipartite nuclear localization signal (IPR001472);DNA/RNA non-specific endonuclease (IPR001604);Somatomedin B (IPR001212);Type I phosphodiesterase/nucleotide pyrophosphatase (IPR002591) low -4.63878048058 219534_x_at CDKN1C BWCR;BWS;CDKN1C;KIP2;WBS;p57 1028 cyclin-dependent kinase inhibitor 1C (p57, Kip2) cell growth and/or maintenance (GO:0008151);cyclin-dependent protein kinase inhibitor activity (GO:0004861);negative regulation of cell proliferation (GO:0008285);nutrient reservoir activity (GO:0045735);oncogenesis (GO:0007048);regulation of cyclin dependent protein kinase activity (GO:0000079);tumor suppressor (GO:0008181) Bipartite nuclear localization signal (IPR001472);Cyclin-dependent kinase inhibitor (IPR003175);Glutelin (IPR000480);Proline-rich region (IPR000694) low -4.6664567181 gnf1h01445_s_at gnf1h01445_s_at None None None None None low -4.74898304003 211991_s_at HLA-DPA1 HLA-DP1A;HLA-DPA1;HLADP;HLASB 3113 major histocompatibility complex, class II, DP alpha 1 MHC class II receptor activity (GO:0045012);antigen presentation, exogenous antigen (GO:0019884);antigen processing, exogenous antigen via MHC class II (GO:0019886);immune response (GO:0006955) Immunoglobulin C-type (IPR003597);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006);MHC Class II alpha chain, alpha-1 domain (IPR001003) low -4.78706598756 gnf1h01546_s_at Hs.523212 None None Transcribed sequence None None low -4.88872522062 204416_x_at APOC1 APOC1 341 apolipoprotein C-I lipid metabolism (GO:0006629);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);lipoprotein metabolism (GO:0042157) Apolipoprotein C-I (IPR006781) low -4.93946653549 213182_x_at CDKN1C BWCR;BWS;CDKN1C;KIP2;WBS;p57 1028 cyclin-dependent kinase inhibitor 1C (p57, Kip2) cell growth and/or maintenance (GO:0008151);cyclin-dependent protein kinase inhibitor activity (GO:0004861);negative regulation of cell proliferation (GO:0008285);nutrient reservoir activity (GO:0045735);oncogenesis (GO:0007048);regulation of cyclin dependent protein kinase activity (GO:0000079);tumor suppressor (GO:0008181) Bipartite nuclear localization signal (IPR001472);Cyclin-dependent kinase inhibitor (IPR003175);Glutelin (IPR000480);Proline-rich region (IPR000694) low -4.94711094885 gnf1h06930_at FLJ14490 FLJ14490 84879 hypothetical protein FLJ14490 None None low -4.96956132878 206023_at NMU NMU 10874 neuromedin U G-protein coupled receptor protein signaling pathway (GO:0007186);digestion (GO:0007586);neuropeptide signaling pathway (GO:0007218);receptor binding (GO:0005102);signal transduction (GO:0007165) Neuromedin U (IPR008199);Neuromedin U, C-terminal (IPR008200) low -5.10648807069 218876_at CGI-38 C16orf1;CGI-38;HSU90653;ZDHHC1;ZNF377 51673 brain specific protein DNA binding (GO:0003677) Bipartite nuclear localization signal (IPR001472);P25-alpha (IPR008907);Zn-finger, DHHC type (IPR001594) low -5.23975863935 209631_s_at GPR37 EDNRBL;GPR37;PAELR 2861 G protein-coupled receptor 37 (endothelin receptor type B-like) G-protein coupled receptor activity (GO:0004930);G-protein coupled receptor activity, unknown ligand (GO:0016526);G-protein coupled receptor protein signaling pathway (GO:0007186);receptor activity (GO:0004872);rhodopsin-like receptor activity (GO:0001584) Bombesin receptor (IPR001556);GPR37 orphan receptor (IPR003909);Rhodopsin-like GPCR superfamily (IPR000276) low -5.27099429115 205840_x_at GH1 GH-N;GH1;GHN 2688 growth hormone 1 hormone activity (GO:0005179);peptide hormone (GO:0005180);signal transduction (GO:0007165) Somatotropin hormone (IPR001400) low -5.32992640615 206135_at ST18 KIAA0535;ST18;ZNF387 9705 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) transcription factor activity (GO:0003700) Bipartite nuclear localization signal (IPR001472) low -5.47602623015 205730_s_at ABLIM3 ABLIM3 22885 actin binding LIM protein family, member 3 actin binding (GO:0003779);cytoskeleton organization and biogenesis (GO:0007010) Villin headpiece (IPR003128);Zn-binding protein, LIM (IPR001781) low -5.57106167119 204379_s_at FGFR3 ACH;CEK2;FGFR3;HSFGFR3EX;JTK4 2261 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) ATP binding (GO:0005524);JAK-STAT cascade (GO:0007259);MAPKKK cascade (GO:0000165);cell growth (GO:0016049);fibroblast growth factor receptor activity (GO:0005007);fibroblast growth factor receptor signaling pathway (GO:0008543);oncogenesis (GO:0007048);protein amino acid phosphorylation (GO:0006468);protein-tyrosine kinase activity (GO:0004713);receptor activity (GO:0004872);skeletal development (GO:0001501);transferase activity (GO:0016740) Immunoglobulin C-2 type (IPR003598);Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006);Protein kinase (IPR000719);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) low -5.65690609014 gnf1h10403_at MAGI1 FLJ31349;MAGI1 154043 membrane associated guanylate kinase interacting protein-like 1 intracellular signaling cascade (GO:0007242);protein binding (GO:0005515) Bipartite nuclear localization signal (IPR001472);PDZ/DHR/GLGF domain (IPR001478);Protein of unknown function DUF1170 (IPR010599);Sterile alpha motif SAM (IPR001660) low -5.88470261276 200832_s_at SCD SCD 6319 stearoyl-CoA desaturase (delta-9-desaturase) fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768) Fatty acid desaturase (IPR005804);Fatty acid desaturase, type 1 (IPR001522) low -6.12666854012 202489_s_at FXYD3 FXYD3;MAT-8;MAT8;PLML 5349 FXYD domain containing ion transport regulator 3 chloride channel activity (GO:0005254);chloride transport (GO:0006821);ion channel activity (GO:0005216);ion transport (GO:0006811) FXYD protein (IPR000272) low -6.21733655268 214586_at GPR37 EDNRBL;GPR37;PAELR 2861 G protein-coupled receptor 37 (endothelin receptor type B-like) G-protein coupled receptor activity (GO:0004930);G-protein coupled receptor activity, unknown ligand (GO:0016526);G-protein coupled receptor protein signaling pathway (GO:0007186);receptor activity (GO:0004872);rhodopsin-like receptor activity (GO:0001584) Bombesin receptor (IPR001556);GPR37 orphan receptor (IPR003909);Rhodopsin-like GPCR superfamily (IPR000276) low -6.4670157042 209351_at KRT14 CK14;EBS3;EBS4;K14;KRT14 3861 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280) 14-3-3 protein (IPR000308);Intermediate filament protein (IPR001664);Keratin, type I (IPR002957);Tachykinin/Neurokinin (IPR002040) low -6.8039523831 209686_at S100B NEF;S100;S100B 6285 S100 calcium binding protein, beta (neural) S100 alpha binding (GO:0048155);S100 beta binding (GO:0048154);astrocyte activation (GO:0048143);calcium ion binding (GO:0005509);calcium ion homeostasis (GO:0006874);cell proliferation (GO:0008283);energy reserve metabolism (GO:0006112);hyperphosphorylation (GO:0048151);immune cell activation (GO:0045321);kinase inhibitor activity (GO:0019210);learning and/or memory (GO:0007611);protein binding (GO:0005515);protein homodimerization activity (GO:0042803);tau protein binding (GO:0048156);zinc ion binding (GO:0008270) Calcium-binding EF-hand (IPR002048);Calcium-binding protein, S-100/ICaBP type (IPR001751) low -7.63103416738 220448_at KCNK12 KCNK12;THIK-2;THIK2 56660 potassium channel, subfamily K, member 12 ion transport (GO:0006811);potassium channel activity (GO:0005267);potassium ion transport (GO:0006813);voltage-gated ion channel activity (GO:0005244) K+ channel, pore region (IPR001622);K+ channel, two pore (IPR003280);THIK K+ channel (IPR005410)