PC-26 p<0.000010 High/Low PC-26 Value ProbeId Name Aliases LocusLink Description Function Protein_Families high 8.87103602894 214063_s_at TF PRO1557;PRO2086 7018 transferrin ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) Bipartite nuclear localization signal (IPR001472);Peptidase S60, transferrin lactoferrin (IPR001156) high 7.69280342351 201820_at KRT5 CK5;EBS2;KRT5;KRT5A 3852 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) structural constituent of cytoskeleton (GO:0005200) AMP-dependent synthetase and ligase (IPR000873);Intermediate filament protein (IPR001664);Keratin, type I (IPR002957);Type II keratin (IPR003054) high 7.6742737104 207935_s_at KRT13 CK13;K13;KRT13;MGC3781 3860 keratin 13 structural constituent of cytoskeleton (GO:0005200) Intermediate filament protein (IPR001664);Keratin, type I (IPR002957) high 7.40910568421 203400_s_at TF PRO1557;PRO2086 7018 transferrin ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) Bipartite nuclear localization signal (IPR001472);Peptidase S60, transferrin lactoferrin (IPR001156) high 6.38400079051 212464_s_at FN1 CIG;FINC;FN1;LETS;MSF 2335 fibronectin 1 acute-phase response (GO:0006953);cell adhesion (GO:0007155);cell migration (GO:0016477);collagen binding (GO:0005518);extracellular matrix structural constituent (GO:0005201);heparin binding (GO:0008201);response to wounding (GO:0009611) Aldehyde dehydrogenase (IPR002086);Bipartite nuclear localization signal (IPR001472);EGF-like domain (IPR006209);Fibronectin, type I (IPR000083);Fibronectin, type III (IPR003961);Fibronectin, type III subdomain (IPR003962);Fibronectin, type III-like fold (IPR008957);Type II fibronectin collagen-binding domain (IPR000562) high 6.24594929647 202283_at SERPINF1 EPC-1;PEDF;SERPINF1 5176 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 cell proliferation (GO:0008283);development (GO:0007275);histogenesis and organogenesis (GO:0007397);neurogenesis (GO:0007399);serine-type endopeptidase inhibitor activity (GO:0004867);serpin (GO:0004868) Proteinase inhibititor I4, serpin (IPR000215);Surface protein from Gram-positive cocci, anchor region (IPR001899) high 6.21092115167 201983_s_at EGFR EGFR;ERBB;ERBB1 1956 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) ATP binding (GO:0005524);cell proliferation (GO:0008283);electron transport (GO:0006118);electron transporter activity (GO:0005489);epidermal growth factor receptor activity (GO:0005006);epidermal growth factor receptor signaling pathway (GO:0007173);iron ion binding (GO:0005506);protein amino acid phosphorylation (GO:0006468);receptor activity (GO:0004872);transferase activity (GO:0016740) Epidermal growth-factor receptor (EGFR), L domain (IPR000494);Furin-like cysteine rich region (IPR006211);Growth factor, receptor (IPR009030);Protein kinase (IPR000719);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) high 5.99671246395 205820_s_at APOC3 APOC3 345 apolipoprotein C-III apolipoprotein (GO:0005320);lipid binding (GO:0008289);lipid catabolism (GO:0016042);lipid metabolism (GO:0006629);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);lipoprotein metabolism (GO:0042157);plasma protein (GO:0005209) Apolipoprotein CIII (IPR008403) high 5.95700187157 206130_s_at ASGR2 ASGP-R;ASGR2;Hs.1259;L-H2 433 asialoglycoprotein receptor 2 asialoglycoprotein receptor activity (GO:0004873);biological_process unknown (GO:0000004);cell surface receptor linked signal transduction (GO:0007166);endocytosis (GO:0006897);heterophilic cell adhesion (GO:0007157);lectin (GO:0005530);receptor activity (GO:0004872);sugar binding (GO:0005529) C-type lectin (IPR001304);Hepatic lectin, N-terminal (IPR005640);Type II antifreeze protein (IPR002353) high 5.79121351474 210049_at SERPINC1 AT3;ATIII;SERPINC1 462 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 blood coagulation (GO:0007596);heparin binding (GO:0008201);protein binding (GO:0005515);serine-type endopeptidase inhibitor activity (GO:0004867) Proteinase inhibititor I4, serpin (IPR000215) high 5.50470609607 204713_s_at F5 FVL;PCCF 2153 coagulation factor V (proaccelerin, labile factor) blood coagulation (GO:0007596);blood coagulation factor activity (GO:0003801);cell adhesion (GO:0007155);copper ion binding (GO:0005507) Bipartite nuclear localization signal (IPR001472);Coagulation factor 5/8 type C domain (FA58C) (IPR000421);Cupredoxin (IPR008972);Galactose-binding like (IPR008979);Multicopper oxidase, type 1 (IPR001117) high 5.39993595905 gnf1h01345_at gnf1h01345_at None None None None None high 5.39780427694 210095_s_at IGFBP3 IBP3;IGFBP3 3486 insulin-like growth factor binding protein 3 cell growth and/or maintenance (GO:0008151);insulin-like growth factor binding (GO:0005520);metal ion binding (GO:0046872);negative regulation of signal transduction (GO:0009968);positive regulation of myoblast differentiation (GO:0045663);protein tyrosine phosphatase activator activity (GO:0008160);regulation of cell growth (GO:0001558);signal transduction (GO:0007165) Bipartite nuclear localization signal (IPR001472);Growth factor, receptor (IPR009030);Insulin-like growth factor-binding protein, IGFBP (IPR000867);Thyroglobulin type-1 (IPR000716) high 5.38867907282 210327_s_at AGXT AGT;AGT1;AGXT;AGXT1;SPAT;SPT;TLH6 189 alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) alanine-glyoxylate transaminase activity (GO:0008453);metabolism (GO:0008152);serine-pyruvate transaminase activity (GO:0004760);transaminase activity (GO:0008483);transferase activity (GO:0016740) Aminotransferase, class V (IPR000192);TONB Box N terminus (IPR010916) high 5.37956763743 204561_x_at APOC2 APOC2 344 apolipoprotein C-II circulation (GO:0008015);enzyme activator activity (GO:0008047);lipid catabolism (GO:0016042);lipid metabolism (GO:0006629);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);lipoprotein lipase activity (GO:0004465) Apolipoprotein C-II (IPR008019) high 5.34139146257 219466_s_at APOA2 APOA2 336 apolipoprotein A-II glucose metabolism (GO:0006006);high-density lipoprotein (GO:0005321);lipid binding (GO:0008289);lipid catabolism (GO:0016042);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);neutrophil activation (GO:0042119);protein heterodimerization activity (GO:0046982);protein homodimerization activity (GO:0042803);response to glucose stimulus (GO:0009749) Apolipoprotein A-II (ApoA-II) (IPR006801) high 5.2508036912 220266_s_at KLF4 EZF;GKLF;KLF4 9314 Kruppel-like factor 4 (gut) negative regulation of cell proliferation (GO:0008285);nucleic acid binding (GO:0003676);transcription activating factor (GO:0003710);transcription factor activity (GO:0003700);transcriptional activator activity (GO:0016563);transcriptional repressor activity (GO:0016564);zinc ion binding (GO:0008270) Proline-rich region (IPR000694);Zn-finger, C2H2 type (IPR007087) high 5.22289777245 209392_at ENPP2 ATX;ENPP2;LysoPLD;PD-IALPHA;PDNP2 5168 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) G-protein coupled receptor protein signaling pathway (GO:0007186);cell motility (GO:0006928);chemotaxis (GO:0006935);endonuclease activity (GO:0004519);hydrolase activity (GO:0016787);nucleic acid binding (GO:0003676);nucleotide diphosphatase activity (GO:0004551);nucleotide metabolism (GO:0009117);phosphate metabolism (GO:0006796);phosphodiesterase I activity (GO:0004528);transcription factor binding (GO:0008134) Bipartite nuclear localization signal (IPR001472);DNA/RNA non-specific endonuclease (IPR001604);Somatomedin B (IPR001212);Type I phosphodiesterase/nucleotide pyrophosphatase (IPR002591) high 5.21519964469 211548_s_at HPGD 15-PGDH;HPGD;PGDH1 3248 hydroxyprostaglandin dehydrogenase 15-(NAD) 15-hydroxyprostaglandin dehydrogenase (NAD+) activity (GO:0016404);catalytic activity (GO:0003824);electron transporter activity (GO:0005489);metabolism (GO:0008152);oxidoreductase activity (GO:0016491);prostaglandin metabolism (GO:0006693);prostaglandin-D synthase activity (GO:0004667) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (IPR003560);Glucose/ribitol dehydrogenase (IPR002347);Insect alcohol dehydrogenase family (IPR002424);Short-chain dehydrogenase/reductase SDR (IPR002198) high 5.14008646019 gnf1h06930_at FLJ14490 FLJ14490 84879 hypothetical protein FLJ14490 None None high 5.12100698151 204450_x_at APOA1 APOA1 335 apolipoprotein A-I cholesterol metabolism (GO:0008203);circulation (GO:0008015);high-density lipoprotein (GO:0005321);high-density lipoprotein binding (GO:0008035);lipid binding (GO:0008289);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);lipoprotein metabolism (GO:0042157);structural molecule activity (GO:0005198) Apolipoprotein A1/A4/E (IPR000074) high 5.10757799714 gnf1h09235_at gnf1h09235_at None None None None None high 5.0694107724 217073_x_at APOA1 APOA1 335 apolipoprotein A-I cholesterol metabolism (GO:0008203);circulation (GO:0008015);high-density lipoprotein (GO:0005321);high-density lipoprotein binding (GO:0008035);lipid binding (GO:0008289);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);lipoprotein metabolism (GO:0042157);structural molecule activity (GO:0005198) Apolipoprotein A1/A4/E (IPR000074) high 5.06791694332 gnf1h08340_at A1BG A1B;A1BG;ABG;GAB 1 alpha-1-B glycoprotein biological_process unknown (GO:0000004);molecular_function unknown (GO:0005554) Immunoglobulin C-2 type (IPR003598);Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006) low -5.22264067448 214974_x_at CXCL5 CXCL5;ENA-78;SCYB5 6374 chemokine (C-X-C motif) ligand 5 cell-cell signaling (GO:0007267);chemokine activity (GO:0008009);chemotaxis (GO:0006935);immune response (GO:0006955);inflammatory response (GO:0006954);positive regulation of cell proliferation (GO:0008284);signal transduction (GO:0007165) Small chemokine, C-X-C subfamily (IPR001089);Small chemokine, C-X-C/Interleukin 8 (IPR002473);Small chemokine, interleukin-8 like (IPR001811) low -5.23666726923 202620_s_at PLOD2 PLOD2 5352 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 oxidoreductase activity (GO:0016491);oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen\, incorporation of two atoms of oxygen (GO:0016702);procollagen-lysine 5-dioxygenase activity (GO:0008475);protein metabolism (GO:0019538);protein modification (GO:0006464) 2OG-Fe(II) oxygenase superfamily (IPR005123);Procollagen-lysine 5-dioxygenase (IPR001006);Prolyl 4-hydroxylase, alpha subunit (IPR006620) low -5.25152502375 209458_x_at HBA2 HBA1;HBA2 3040 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) Alpha haemoglobin (IPR002338);Globin (IPR000971);Globin-like (IPR009050);Pi haemoglobin (IPR002339) low -5.26207484093 205589_at MYL3 MLC1V;MYL3;VLC1 4634 myosin, light polypeptide 3, alkali; ventricular, skeletal, slow calcium ion binding (GO:0005509);muscle contraction (GO:0006936);muscle development (GO:0007517);structural constituent of muscle (GO:0008307) Calcium-binding EF-hand (IPR002048) low -5.26623403236 203863_at ACTN2 ACTN2 88 actinin, alpha 2 actin binding (GO:0003779);calcium ion binding (GO:0005509);protein binding (GO:0005515);structural constituent of muscle (GO:0008307) Actin-binding, actinin-type (IPR001589);Calcium-binding EF-hand (IPR002048);Calponin-like actin-binding (IPR001715) low -5.268442106 gnf1h09294_s_at HBG1 HBG1;HBGA;HBGR 3047 hemoglobin, gamma A oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) Beta haemoglobin (IPR002337);Globin (IPR000971);Globin-like (IPR009050) low -5.30864525556 205826_at MYOM2 MYOM2;TTNAP 9172 myomesin (M-protein) 2, 165kDa muscle contraction (GO:0006936);muscle development (GO:0007517);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) Fibronectin, type III (IPR003961);Fibronectin, type III subdomain (IPR003962);Fibronectin, type III-like fold (IPR008957);Immunoglobulin C-2 type (IPR003598);Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006) low -5.34756049695 205615_at CPA1 CPA;CPA1 1357 carboxypeptidase A1 (pancreatic) carboxypeptidase A activity (GO:0004182);carboxypeptidase activity (GO:0004180);hydrolase activity (GO:0016787);metallopeptidase activity (GO:0008237);proteolysis and peptidolysis (GO:0006508) Peptidase M14, carboxypeptidase A (IPR000834);Proteinase inhibitor, carboxypeptidase propeptide (IPR003146);Proteinase inhibitor, propeptide (IPR009020) low -5.37525115251 216470_x_at 216470_x_at None None T cell receptor beta locus None None low -5.39171198386 211745_x_at HBA2 HBA1;HBA2 3040 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) Alpha haemoglobin (IPR002338);Globin (IPR000971);Globin-like (IPR009050);Pi haemoglobin (IPR002339) low -5.46400403157 204737_s_at MYH7 CMH1;MYH7;MYHCB 4625 myosin, heavy polypeptide 7, cardiac muscle, beta ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) IQ calmodulin-binding region (IPR000048);Myosin N-terminal SH3-like domain (IPR004009);Myosin head (motor domain) (IPR001609);Myosin tail (IPR002928);Tropomyosin (IPR000533) low -5.47425602625 205942_s_at SAH SAH 6296 SA hypertension-associated homolog (rat) catalytic activity (GO:0003824);metabolism (GO:0008152);regulation of blood pressure (GO:0008217) AMP-dependent synthetase and ligase (IPR000873);Amino acid adenylation (IPR010071);O-succinylbenzoate-CoA ligase (IPR010192) low -5.49501011717 206834_at HBD HBD 3045 hemoglobin, delta globin (GO:0001524);oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) Beta haemoglobin (IPR002337);Globin (IPR000971);Globin-like (IPR009050) low -5.57526268095 214414_x_at HBA2 HBA1;HBA2 3040 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) Alpha haemoglobin (IPR002338);Globin (IPR000971);Globin-like (IPR009050);Pi haemoglobin (IPR002339) low -5.6172581164 212070_at GPR56 GPR56;TM7LN4;TM7XN1 9289 G protein-coupled receptor 56 G-protein coupled receptor activity (GO:0004930);G-protein coupled receptor protein signaling pathway (GO:0007186);catalytic activity (GO:0003824);cell adhesion (GO:0007155);cell-cell signaling (GO:0007267);metabolism (GO:0008152);neuropeptide signaling pathway (GO:0007218);receptor activity (GO:0004872) AMP-dependent synthetase and ligase (IPR000873);G-protein coupled receptor family 2 (secretin-like) (IPR000832);GPR56 orphan receptor (IPR003910);GPS domain (IPR000203) low -5.7078501959 211699_x_at HBA2 HBA1;HBA2 3040 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) Alpha haemoglobin (IPR002338);Globin (IPR000971);Globin-like (IPR009050);Pi haemoglobin (IPR002339) low -5.87169655049 206446_s_at ELA2A ELA2A 63036 elastase 2A chymotrypsin activity (GO:0004263);hydrolase activity (GO:0016787);pancreatic elastase II activity (GO:0004281);pancreatic elastase activity (GO:0008132);proteolysis and peptidolysis (GO:0006508);trypsin activity (GO:0004295) Peptidase S1, chymotrypsin (IPR001254);Peptidase S1A, chymotrypsin (IPR001314);Peptidase, trypsin-like serine and cysteine proteases (IPR009003) low -5.92192900027 205402_x_at PRSS2 PRSS1;PRSS2;TRP1;TRY1;TRY2;TRY4;TRY8;TRYP1;TRYP2 5645 protease, serine, 2 (trypsin 2) calcium ion binding (GO:0005509);chymotrypsin activity (GO:0004263);digestion (GO:0007586);hydrolase activity (GO:0016787);peptidase activity (GO:0008233);proteolysis and peptidolysis (GO:0006508);trypsin activity (GO:0004295) Peptidase S1, chymotrypsin (IPR001254);Peptidase S1A, chymotrypsin (IPR001314);Peptidase, trypsin-like serine and cysteine proteases (IPR009003) low -5.96951221688 209700_x_at PDE4DIP CMYA2;KIAA0454;KIAA0477;MMGL;PDE4DIP 9659 phosphodiesterase 4D interacting protein (myomegalin) None None low -6.28619197372 205869_at PRSS2 PRSS1;PRSS2;TRP1;TRY1;TRY2;TRY4;TRY8;TRYP1;TRYP2 5645 protease, serine, 2 (trypsin 2) calcium ion binding (GO:0005509);chymotrypsin activity (GO:0004263);digestion (GO:0007586);hydrolase activity (GO:0016787);peptidase activity (GO:0008233);proteolysis and peptidolysis (GO:0006508);trypsin activity (GO:0004295) Peptidase S1, chymotrypsin (IPR001254);Peptidase S1A, chymotrypsin (IPR001314);Peptidase, trypsin-like serine and cysteine proteases (IPR009003) low -6.48339177345 209771_x_at CD24 CD24;CD24A 934 CD24 antigen (small cell lung carcinoma cluster 4 antigen) humoral immune response (GO:0006959) None low -6.6379756528 206422_at GCG GCG;GLP1;GLP2;GRPP 2641 glucagon G-protein coupled receptor protein signaling pathway (GO:0007186);cell proliferation (GO:0008283);feeding behavior (GO:0007631);hormone activity (GO:0005179);peptide hormone (GO:0005180);receptor binding (GO:0005102);signal transduction (GO:0007165) Bipartite nuclear localization signal (IPR001472) low -6.77326568827 209116_x_at HBB HBB 3043 hemoglobin, beta oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) Beta haemoglobin (IPR002337);Globin (IPR000971);Globin-like (IPR009050);Myoglobin (IPR002335) low -6.77590212829 219196_at SCG3 SCG3;SGIII 29106 secretogranin III chemotaxis (GO:0006935);signal transduction (GO:0007165);transmembrane receptor activity (GO:0004888) None low -7.06182640457 205910_s_at CEL BAL;BSDL;BSSL;CEL;CELL;CEase;FAP;FAPP;LIPA 1056 carboxyl ester lipase (bile salt-stimulated lipase) catalytic activity (GO:0003824);cell differentiation (GO:0030154);cell growth (GO:0016049);cholesterol catabolism (GO:0006707);fat-soluble vitamin catabolism (GO:0042363);hydrolase activity (GO:0016787);lipase activity (GO:0016298);lipid catabolism (GO:0016042);lipid metabolism (GO:0006629);protein binding (GO:0005515);serine esterase activity (GO:0004759);sterol esterase activity (GO:0004771) Carboxylesterase, type B (IPR002018);Cholinesterase (IPR000997);Esterase/lipase/thioesterase (IPR000379);Proline-rich region (IPR000694) low -7.26199214732 217414_x_at HBA2 HBA1;HBA2 3040 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) Alpha haemoglobin (IPR002338);Globin (IPR000971);Globin-like (IPR009050);Pi haemoglobin (IPR002339)