PC-30 p<0.000010 High/Low PC-30 Value ProbeId Name Aliases LocusLink Description Function Protein_Families high 9.54605814459 219529_at CLIC3 CLIC3 9022 chloride intracellular channel 3 chloride channel activity (GO:0005254);chloride transport (GO:0006821);ion transport (GO:0006811);signal transduction (GO:0007165);small molecule transport (GO:0006832);transport (GO:0006810);voltage-gated chloride channel activity (GO:0005247) Glutathione S-transferase, N-terminal (IPR004045);Intracellular chloride channel (IPR002946) high 6.27045268262 gnf1h01161_at SLC26A7 SLC26A7;SUT2 115111 solute carrier family 26, member 7 sulfate porter activity (GO:0008271);sulfate transport (GO:0008272) Sulfate transporter/antisigma-factor antagonist STAS (IPR002645);Sulphate transporter (IPR001902) high 5.96706486865 210342_s_at TPO MSA;TPO;TPX 7173 thyroid peroxidase calcium ion binding (GO:0005509);iodide peroxidase activity (GO:0004447);oxidoreductase activity (GO:0016491);peroxidase activity (GO:0004601);response to oxidative stress (GO:0006979);thyroid hormone generation (GO:0006590) Animal haem peroxidase (IPR002007);EGF-like calcium-binding (IPR001881);EGF-like domain (IPR006209);Haem peroxidase, plant/fungal/bacterial (IPR002016);Sushi domain/SCR domain/CCP module (IPR000436) high 5.5967142804 210055_at TSHR LGR3;TSHR 7253 thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 5.09767722952 201131_s_at CDH1 CDH1;CDHE;ECAD;LCAM;UVO 999 cadherin 1, type 1, E-cadherin (epithelial) calcium ion binding (GO:0005509);calcium-dependent cell adhesion molecule activity (GO:0008014);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);homophilic cell adhesion (GO:0007156);protein binding (GO:0005515);tumor suppressor (GO:0008181) Cadherin (IPR002126);Cadherin cytoplasmic region (IPR000233) high 5.00182644426 214032_at ZAP70 SRK;STD;TZK;ZAP-70;ZAP70 7535 zeta-chain (TCR) associated protein kinase 70kDa ATP binding (GO:0005524);immune response (GO:0006955);protein amino acid phosphorylation (GO:0006468);protein binding (GO:0005515);protein kinase cascade (GO:0007243);protein-tyrosine kinase activity (GO:0004713);transferase activity (GO:0016740) Protein kinase (IPR000719);SH2 motif (IPR000980);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) high 4.92688629334 218559_s_at MAFB KRML;MAFB;MGC43127 9935 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) DNA binding (GO:0003677) Basic-leucine zipper (bZIP) transcription factor (IPR004827);Bipartite nuclear localization signal (IPR001472);Eukaryotic transcription factor, DNA-binding (IPR008917);Maf transcription factor (IPR004826) high 4.90454107308 210181_s_at CABP1 CABP1;CALBRAIN;HCALB_BR 9478 calcium binding protein 1 (calbrain) calcium ion binding (GO:0005509);enzyme inhibitor activity (GO:0004857) Calcium-binding EF-hand (IPR002048) high 4.88970582519 203980_at FABP4 A-FABP;FABP4 2167 fatty acid binding protein 4, adipocyte fatty acid binding (GO:0005504);transport (GO:0006810);transporter activity (GO:0005215) Cytosolic fatty-acid binding protein (IPR000463);Lipocalin-related protein and Bos/Can/Equ allergen (IPR000566) high 4.76797344467 AFFX-HUMRGE/M10098_5_at AFFX-HUMRGE/M10098_5_at None None M10098 Human 18S rRNA gene, complete (_5, _M, _3 represent transcript regions 5 prime, Middle, and 3 prime respectively) None None high 4.73310807745 201206_s_at RRBP1 ES/130;ES130;RRBP1 6238 ribosome binding protein 1 homolog 180kDa (dog) biological_process unknown (GO:0000004);extracellular matrix glycoprotein (GO:0005207);protein biosynthesis (GO:0006412);protein targeting (GO:0006605);protein transporter activity (GO:0008565);receptor activity (GO:0004872);ribosome receptor activity (GO:0030376);signal transduction (GO:0007165) Bipartite nuclear localization signal (IPR001472);Ribosome receptor lysine or proline rich (IPR007794);Tropomyosin (IPR000533) high 4.70900093688 213381_at C10orf72 C10orf72;FLJ31737 196740 chromosome 10 open reading frame 72 None Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110) high 4.55985185794 203673_at TG None 7038 thyroglobulin carboxylic ester hydrolase activity (GO:0016789);hormone activity (GO:0005179);signal transduction (GO:0007165);thyroid hormone generation (GO:0006590) Carboxylesterase, type B (IPR002018);Thyroglobulin type-1 (IPR000716) high 4.47285552164 215442_s_at TSHR LGR3;TSHR 7253 thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 4.45221421862 208928_at POR CYPOR;POR 5447 P450 (cytochrome) oxidoreductase NADPH-hemoprotein reductase activity (GO:0003958);cytochrome P450 activity (GO:0015034);electron transport (GO:0006118);oxidoreductase activity (GO:0016491) FAD-binding (IPR003097);Flavodoxin-like domain (IPR001094);Flavodoxin/nitric oxide synthase (IPR008254);Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709);Oxidoreductase FAD/NAD(P)-binding (IPR001433) low -5.40212926824 207961_x_at MYH11 MYH11;SMHC;SMMHC 4629 myosin, heavy polypeptide 11, smooth muscle ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);cell growth and/or maintenance (GO:0008151);motor activity (GO:0003774);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) Bipartite nuclear localization signal (IPR001472);IQ calmodulin-binding region (IPR000048);Myosin N-terminal SH3-like domain (IPR004009);Myosin head (motor domain) (IPR001609);Myosin tail (IPR002928) low -5.40396256184 215339_at NKTR NKTR 4820 natural killer-tumor recognition sequence cyclophilin (GO:0004600);cyclosporin A binding (GO:0016018);isomerase activity (GO:0016853);peptidyl-prolyl cis-trans isomerase activity (GO:0003755);protein folding (GO:0006457) Bipartite nuclear localization signal (IPR001472);Peptidyl-prolyl cis-trans isomerase, cyclophilin type (IPR002130) low -5.53383788712 207387_s_at GK GKD 2710 glycerol kinase ATP binding (GO:0005524);carbohydrate metabolism (GO:0005975);glycerol kinase activity (GO:0004370);glycerol metabolism (GO:0006071);glycerol-3-phosphate metabolism (GO:0006072);transferase activity (GO:0016740) Carbohydrate kinase, FGGY (IPR000577);Glycerol kinase (IPR005999) low -5.55256308206 gnf1h01497_s_at gnf1h01497_s_at None None None None None low -5.59024926381 202274_at ACTG2 ACTA3;ACTE;ACTG2;ACTSG 72 actin, gamma 2, smooth muscle, enteric motor activity (GO:0003774);muscle development (GO:0007517);structural constituent of cytoskeleton (GO:0005200);structural constituent of muscle (GO:0008307) Actin (IPR004001);Actin/actin-like (IPR004000) low -5.68322371815 207262_at STAT2 APOF;ISGF-3;MGC59816;P113;STAT113;STAT2 6773 signal transducer and activator of transcription 2, 113kDa JAK-STAT cascade (GO:0007259);apolipoprotein (GO:0005320);cholesterol binding (GO:0015485);cholesterol metabolism (GO:0008203);hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity (GO:0005062);high-density lipoprotein binding (GO:0008035);intracellular signaling cascade (GO:0007242);lipid metabolism (GO:0006629);lipid transport (GO:0006869);lipid transporter activity (GO:0005319);receptor binding (GO:0005102);signal transducer activity (GO:0004871);transcription activating factor (GO:0003710);transcription factor activity (GO:0003700);translation regulator activity (GO:0045182) SH2 motif (IPR000980);STAT protein (IPR001217);p53-like transcription factor, DNA-binding (IPR008967) low -5.88572107059 202222_s_at DES CMD1I;CSM1;CSM2;DES;FLJ12025 1674 desmin cytoskeleton organization and biogenesis (GO:0007010);muscle contraction (GO:0006936);muscle development (GO:0007517);regulation of heart rate (GO:0008016);structural constituent of cytoskeleton (GO:0005200) Intermediate filament protein (IPR001664);Intermediate filament, DNA-binding region (IPR006821) low -6.3371137547 201497_x_at MYH11 MYH11;SMHC;SMMHC 4629 myosin, heavy polypeptide 11, smooth muscle ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);cell growth and/or maintenance (GO:0008151);motor activity (GO:0003774);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) Bipartite nuclear localization signal (IPR001472);IQ calmodulin-binding region (IPR000048);Myosin N-terminal SH3-like domain (IPR004009);Myosin head (motor domain) (IPR001609);Myosin tail (IPR002928) low -6.78611646472 203951_at CNN1 CNN1;SMCC;Sm-Calp 1264 calponin 1, basic, smooth muscle actin binding (GO:0003779);actin filament binding (GO:0051015);calmodulin binding (GO:0005516);muscle contraction (GO:0006936);smooth muscle contraction (GO:0006939) Calponin (IPR001997);Calponin-like actin-binding (IPR001715);Calponin-like actin-binding subtype (IPR003247);SM22/calponin (IPR003096) low -6.86953366364 201496_x_at MYH11 MYH11;SMHC;SMMHC 4629 myosin, heavy polypeptide 11, smooth muscle ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);cell growth and/or maintenance (GO:0008151);motor activity (GO:0003774);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) Bipartite nuclear localization signal (IPR001472);IQ calmodulin-binding region (IPR000048);Myosin N-terminal SH3-like domain (IPR004009);Myosin head (motor domain) (IPR001609);Myosin tail (IPR002928) low -6.9885782915 203949_at MPO MPO 4353 myeloperoxidase calcium ion binding (GO:0005509);chromatin binding (GO:0003682);defense response (GO:0006952);oxidoreductase activity (GO:0016491);peroxidase activity (GO:0004601);response to oxidative stress (GO:0006979) Animal haem peroxidase (IPR002007);Haem peroxidase, plant/fungal/bacterial (IPR002016) low -7.59905219239 209189_at FOS FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog DNA binding (GO:0003677);DNA methylation (GO:0006306);cell growth and/or maintenance (GO:0008151);inflammatory response (GO:0006954);oncogenesis (GO:0007048);specific RNA polymerase II transcription factor activity (GO:0003704);transcription from Pol II promoter (GO:0006366) Basic-leucine zipper (bZIP) transcription factor (IPR004827);Bipartite nuclear localization signal (IPR001472);Fos transforming protein (IPR000837)