PC-25 10 High/Low PC-25 Value ProbeId Name Aliases Description Function Protein Families high 8.04196019255 210342_s_at TPO MSA;TPO;TPX thyroid peroxidase calcium ion binding (GO:0005509);iodide peroxidase activity (GO:0004447);oxidoreductase activity (GO:0016491);peroxidase activity (GO:0004601);response to oxidative stress (GO:0006979);thyroid hormone generation (GO:0006590) Animal haem peroxidase (IPR002007);EGF-like calcium-binding (IPR001881);EGF-like domain (IPR006209);Haem peroxidase, plant/fungal/bacterial (IPR002016);Sushi domain/SCR domain/CCP module (IPR000436) high 7.88827518049 203673_at TG None thyroglobulin carboxylic ester hydrolase activity (GO:0016789);hormone activity (GO:0005179);signal transduction (GO:0007165);thyroid hormone generation (GO:0006590) Carboxylesterase, type B (IPR002018);Thyroglobulin type-1 (IPR000716) high 7.48247535376 203953_s_at CLDN3 CLDN3;CPE-R2;CPETR2;HRVP1;RVP1 claudin 3 structural molecule activity (GO:0005198);transmembrane receptor activity (GO:0004888) Claudin region (IPR006188);Claudin tight junction protein (IPR006187);Claudin-14 (IPR003556);Claudin-3 (IPR003549);PMP-22/EMP/MP20 and claudin (IPR004031) high 7.41612119739 204487_s_at KCNQ1 ATFB1;KCNA8;KCNA9;KCNQ1;KVLQT1;Kv1.9;Kv7.1;LQT;LQT1;RWS;WRS potassium voltage-gated channel, KQT-like subfamily, member 1 cation transport (GO:0006812);delayed rectifier potassium channel activity (GO:0005251);ion channel activity (GO:0005216);ion transport (GO:0006811);muscle contraction (GO:0006936);perception of sound (GO:0007605);potassium ion transport (GO:0006813);regulation of heart rate (GO:0008016);voltage-gated potassium channel activity (GO:0005249) Cation channel, non-ligand gated (IPR005820);Ion transport protein (IPR005821);K+ channel, pore region (IPR001622);KCNQ voltage-gated potassium channel (IPR003937);Proline-rich region (IPR000694);Voltage-dependent potassium channel (IPR003091) high 7.3026787314 215443_at TSHR LGR3;TSHR thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 7.20121506805 209552_at PAX8 PAX8 paired box gene 8 DNA binding (GO:0003677);biological_process unknown (GO:0000004);cell differentiation (GO:0030154);development (GO:0007275);embryogenesis and morphogenesis (GO:0007345);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);morphogenesis (GO:0009653);thyroid-stimulating hormone receptor activity (GO:0004996);transcription (GO:0006350);transcription factor activity (GO:0003700) Homeodomain-like (IPR009057);Paired box protein, N-terminal (IPR001523);Proline-rich region (IPR000694) high 6.99172757368 210055_at TSHR LGR3;TSHR thyroid stimulating hormone receptor G-protein coupled receptor protein signaling pathway (GO:0007186);G-protein signaling\, coupled to cyclic nucleotide second messenger (GO:0007187);cell-cell signaling (GO:0007267);oncogenesis (GO:0007048);pathogenesis (GO:0009405);physiological process (GO:0007582);positive regulation of cell proliferation (GO:0008284);protein-hormone receptor activity (GO:0016500);receptor activity (GO:0004872);thyroid-stimulating hormone receptor activity (GO:0004996) Glycoprotein hormone receptor (IPR002131);Rhodopsin-like GPCR superfamily (IPR000276);Thyrotropin receptor (IPR002274) high 6.7733871152 gnf1h09294_s_at HBG1 HBG1;HBGA;HBGR hemoglobin, gamma A oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) Beta haemoglobin (IPR002337);Globin (IPR000971);Globin-like (IPR009050) high 6.7143615546 gnf1h09872_at gnf1h09872_at None None None None high 6.61678121134 214528_s_at PAX8 PAX8 paired box gene 8 DNA binding (GO:0003677);biological_process unknown (GO:0000004);cell differentiation (GO:0030154);development (GO:0007275);embryogenesis and morphogenesis (GO:0007345);histogenesis and organogenesis (GO:0007397);molecular_function unknown (GO:0005554);morphogenesis (GO:0009653);thyroid-stimulating hormone receptor activity (GO:0004996);transcription (GO:0006350);transcription factor activity (GO:0003700) Homeodomain-like (IPR009057);Paired box protein, N-terminal (IPR001523);Proline-rich region (IPR000694) low -5.32992640617 206135_at ST18 KIAA0535;ST18;ZNF387 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) transcription factor activity (GO:0003700) Bipartite nuclear localization signal (IPR001472) low -5.47602623013 205730_s_at ABLIM3 ABLIM3 actin binding LIM protein family, member 3 actin binding (GO:0003779);cytoskeleton organization and biogenesis (GO:0007010) Villin headpiece (IPR003128);Zn-binding protein, LIM (IPR001781) low -5.57106167114 204379_s_at FGFR3 ACH;CEK2;FGFR3;HSFGFR3EX;JTK4 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) ATP binding (GO:0005524);JAK-STAT cascade (GO:0007259);MAPKKK cascade (GO:0000165);cell growth (GO:0016049);fibroblast growth factor receptor activity (GO:0005007);fibroblast growth factor receptor signaling pathway (GO:0008543);oncogenesis (GO:0007048);protein amino acid phosphorylation (GO:0006468);protein-tyrosine kinase activity (GO:0004713);receptor activity (GO:0004872);skeletal development (GO:0001501);transferase activity (GO:0016740) Immunoglobulin C-2 type (IPR003598);Immunoglobulin subtype (IPR003599);Immunoglobulin-like (IPR007110);Immunoglobulin/major histocompatibility complex (IPR003006);Protein kinase (IPR000719);Serine/threonine protein kinase (IPR002290);Tyrosine protein kinase (IPR001245) low -5.65690609014 gnf1h10403_at MAGI1 FLJ31349;MAGI1 membrane associated guanylate kinase interacting protein-like 1 intracellular signaling cascade (GO:0007242);protein binding (GO:0005515) Bipartite nuclear localization signal (IPR001472);PDZ/DHR/GLGF domain (IPR001478);Protein of unknown function DUF1170 (IPR010599);Sterile alpha motif SAM (IPR001660) low -5.88470261276 200832_s_at SCD SCD stearoyl-CoA desaturase (delta-9-desaturase) fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768) Fatty acid desaturase (IPR005804);Fatty acid desaturase, type 1 (IPR001522) low -6.12666854011 202489_s_at FXYD3 FXYD3;MAT-8;MAT8;PLML FXYD domain containing ion transport regulator 3 chloride channel activity (GO:0005254);chloride transport (GO:0006821);ion channel activity (GO:0005216);ion transport (GO:0006811) FXYD protein (IPR000272) low -6.21733655269 214586_at GPR37 EDNRBL;GPR37;PAELR G protein-coupled receptor 37 (endothelin receptor type B-like) G-protein coupled receptor activity (GO:0004930);G-protein coupled receptor activity, unknown ligand (GO:0016526);G-protein coupled receptor protein signaling pathway (GO:0007186);receptor activity (GO:0004872);rhodopsin-like receptor activity (GO:0001584) Bombesin receptor (IPR001556);GPR37 orphan receptor (IPR003909);Rhodopsin-like GPCR superfamily (IPR000276) low -6.46701570417 209351_at KRT14 CK14;EBS3;EBS4;K14;KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280) 14-3-3 protein (IPR000308);Intermediate filament protein (IPR001664);Keratin, type I (IPR002957);Tachykinin/Neurokinin (IPR002040) low -6.80395238313 209686_at S100B NEF;S100;S100B S100 calcium binding protein, beta (neural) S100 alpha binding (GO:0048155);S100 beta binding (GO:0048154);astrocyte activation (GO:0048143);calcium ion binding (GO:0005509);calcium ion homeostasis (GO:0006874);cell proliferation (GO:0008283);energy reserve metabolism (GO:0006112);hyperphosphorylation (GO:0048151);immune cell activation (GO:0045321);kinase inhibitor activity (GO:0019210);learning and/or memory (GO:0007611);protein binding (GO:0005515);protein homodimerization activity (GO:0042803);tau protein binding (GO:0048156);zinc ion binding (GO:0008270) Calcium-binding EF-hand (IPR002048);Calcium-binding protein, S-100/ICaBP type (IPR001751) low -7.63103416736 220448_at KCNK12 KCNK12;THIK-2;THIK2 potassium channel, subfamily K, member 12 ion transport (GO:0006811);potassium channel activity (GO:0005267);potassium ion transport (GO:0006813);voltage-gated ion channel activity (GO:0005244) K+ channel, pore region (IPR001622);K+ channel, two pore (IPR003280);THIK K+ channel (IPR005410)