Merge commit 'upstream/0.5'
[pysam.git] / pysam / cvcf.c
diff --git a/pysam/cvcf.c b/pysam/cvcf.c
new file mode 100644 (file)
index 0000000..82eae7d
--- /dev/null
@@ -0,0 +1,26340 @@
+/* Generated by Cython 0.13 on Thu May  5 15:40:49 2011 */
+
+#define PY_SSIZE_T_CLEAN
+#include "Python.h"
+#ifndef Py_PYTHON_H
+    #error Python headers needed to compile C extensions, please install development version of Python.
+#else
+
+#include <stddef.h> /* For offsetof */
+#ifndef offsetof
+#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
+#endif
+
+#if !defined(WIN32) && !defined(MS_WINDOWS)
+  #ifndef __stdcall
+    #define __stdcall
+  #endif
+  #ifndef __cdecl
+    #define __cdecl
+  #endif
+  #ifndef __fastcall
+    #define __fastcall
+  #endif
+#endif
+
+#ifndef DL_IMPORT
+  #define DL_IMPORT(t) t
+#endif
+#ifndef DL_EXPORT
+  #define DL_EXPORT(t) t
+#endif
+
+#ifndef PY_LONG_LONG
+  #define PY_LONG_LONG LONG_LONG
+#endif
+
+#if PY_VERSION_HEX < 0x02040000
+  #define METH_COEXIST 0
+  #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
+  #define PyDict_Contains(d,o)   PySequence_Contains(d,o)
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+  typedef int Py_ssize_t;
+  #define PY_SSIZE_T_MAX INT_MAX
+  #define PY_SSIZE_T_MIN INT_MIN
+  #define PY_FORMAT_SIZE_T ""
+  #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
+  #define PyInt_AsSsize_t(o)   PyInt_AsLong(o)
+  #define PyNumber_Index(o)    PyNumber_Int(o)
+  #define PyIndex_Check(o)     PyNumber_Check(o)
+  #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+  #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
+  #define Py_TYPE(ob)   (((PyObject*)(ob))->ob_type)
+  #define Py_SIZE(ob)   (((PyVarObject*)(ob))->ob_size)
+  #define PyVarObject_HEAD_INIT(type, size) \
+          PyObject_HEAD_INIT(type) size,
+  #define PyType_Modified(t)
+
+  typedef struct {
+     void *buf;
+     PyObject *obj;
+     Py_ssize_t len;
+     Py_ssize_t itemsize;
+     int readonly;
+     int ndim;
+     char *format;
+     Py_ssize_t *shape;
+     Py_ssize_t *strides;
+     Py_ssize_t *suboffsets;
+     void *internal;
+  } Py_buffer;
+
+  #define PyBUF_SIMPLE 0
+  #define PyBUF_WRITABLE 0x0001
+  #define PyBUF_FORMAT 0x0004
+  #define PyBUF_ND 0x0008
+  #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
+  #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
+  #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
+  #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
+  #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
+
+#endif
+
+#if PY_MAJOR_VERSION < 3
+  #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
+#else
+  #define __Pyx_BUILTIN_MODULE_NAME "builtins"
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+  #define Py_TPFLAGS_CHECKTYPES 0
+  #define Py_TPFLAGS_HAVE_INDEX 0
+#endif
+
+#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
+  #define Py_TPFLAGS_HAVE_NEWBUFFER 0
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+  #define PyBaseString_Type            PyUnicode_Type
+  #define PyStringObject               PyUnicodeObject
+  #define PyString_Type                PyUnicode_Type
+  #define PyString_Check               PyUnicode_Check
+  #define PyString_CheckExact          PyUnicode_CheckExact
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+  #define PyBytesObject                PyStringObject
+  #define PyBytes_Type                 PyString_Type
+  #define PyBytes_Check                PyString_Check
+  #define PyBytes_CheckExact           PyString_CheckExact
+  #define PyBytes_FromString           PyString_FromString
+  #define PyBytes_FromStringAndSize    PyString_FromStringAndSize
+  #define PyBytes_FromFormat           PyString_FromFormat
+  #define PyBytes_DecodeEscape         PyString_DecodeEscape
+  #define PyBytes_AsString             PyString_AsString
+  #define PyBytes_AsStringAndSize      PyString_AsStringAndSize
+  #define PyBytes_Size                 PyString_Size
+  #define PyBytes_AS_STRING            PyString_AS_STRING
+  #define PyBytes_GET_SIZE             PyString_GET_SIZE
+  #define PyBytes_Repr                 PyString_Repr
+  #define PyBytes_Concat               PyString_Concat
+  #define PyBytes_ConcatAndDel         PyString_ConcatAndDel
+  #define PySet_Check(obj)             PyObject_TypeCheck(obj, &PySet_Type)
+  #define PyFrozenSet_Check(obj)       PyObject_TypeCheck(obj, &PyFrozenSet_Type)
+#endif
+
+#ifndef PySet_CheckExact
+#  define PySet_CheckExact(obj)          (Py_TYPE(obj) == &PySet_Type)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+  #define PyInt_Type                   PyLong_Type
+  #define PyInt_Check(op)              PyLong_Check(op)
+  #define PyInt_CheckExact(op)         PyLong_CheckExact(op)
+  #define PyInt_FromString             PyLong_FromString
+  #define PyInt_FromUnicode            PyLong_FromUnicode
+  #define PyInt_FromLong               PyLong_FromLong
+  #define PyInt_FromSize_t             PyLong_FromSize_t
+  #define PyInt_FromSsize_t            PyLong_FromSsize_t
+  #define PyInt_AsLong                 PyLong_AsLong
+  #define PyInt_AS_LONG                PyLong_AS_LONG
+  #define PyInt_AsSsize_t              PyLong_AsSsize_t
+  #define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
+  #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+  #define PyBoolObject PyLongObject
+#endif
+
+
+#if PY_MAJOR_VERSION >= 3
+  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
+  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
+#else
+  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
+  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+  #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),((char *)(n)))
+  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
+  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),((char *)(n)))
+#else
+  #define __Pyx_GetAttrString(o,n)   PyObject_GetAttrString((o),(n))
+  #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
+  #define __Pyx_DelAttrString(o,n)   PyObject_DelAttrString((o),(n))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+  #define __Pyx_NAMESTR(n) ((char *)(n))
+  #define __Pyx_DOCSTR(n)  ((char *)(n))
+#else
+  #define __Pyx_NAMESTR(n) (n)
+  #define __Pyx_DOCSTR(n)  (n)
+#endif
+
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+
+#if defined(WIN32) || defined(MS_WINDOWS)
+#define _USE_MATH_DEFINES
+#endif
+#include <math.h>
+#define __PYX_HAVE_API__cvcf
+#include "stdlib.h"
+#include "string.h"
+#include "stdint.h"
+#include "stdio.h"
+#include "ctype.h"
+#include "sys/types.h"
+#include "sys/stat.h"
+#include "fcntl.h"
+#include "unistd.h"
+#include "bgzf.h"
+#include "tabix.h"
+
+/* inline attribute */
+#ifndef CYTHON_INLINE
+  #if defined(__GNUC__)
+    #define CYTHON_INLINE __inline__
+  #elif defined(_MSC_VER)
+    #define CYTHON_INLINE __inline
+  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+    #define CYTHON_INLINE inline
+  #else
+    #define CYTHON_INLINE 
+  #endif
+#endif
+
+/* unused attribute */
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+#     define CYTHON_UNUSED __attribute__ ((__unused__)) 
+#   else
+#     define CYTHON_UNUSED
+#   endif
+# elif defined(__ICC) || defined(__INTEL_COMPILER)
+#   define CYTHON_UNUSED __attribute__ ((__unused__)) 
+# else
+#   define CYTHON_UNUSED 
+# endif
+#endif
+
+typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
+
+
+/* Type Conversion Predeclarations */
+
+#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
+#define __Pyx_PyBytes_AsUString(s)   ((unsigned char*) PyBytes_AsString(s))
+
+#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
+
+#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
+
+
+#ifdef __GNUC__
+/* Test for GCC > 2.95 */
+#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)) 
+#define likely(x)   __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* __GNUC__ > 2 ... */
+#define likely(x)   (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ > 2 ... */
+#else /* __GNUC__ */
+#define likely(x)   (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+    
+static PyObject *__pyx_m;
+static PyObject *__pyx_b;
+static PyObject *__pyx_empty_tuple;
+static PyObject *__pyx_empty_bytes;
+static int __pyx_lineno;
+static int __pyx_clineno = 0;
+static const char * __pyx_cfilenm= __FILE__;
+static const char *__pyx_filename;
+
+
+static const char *__pyx_f[] = {
+  "cvcf.pyx",
+  "ctabix.pxd",
+  "TabProxies.pxd",
+};
+
+/* Type declarations */
+
+/* "pysam/TabProxies.pxd":42
+ *   ctypedef int uint64_t
+ * 
+ * cdef class TupleProxy:             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_obj_10TabProxies_TupleProxy {
+  PyObject_HEAD
+  struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtab;
+  char *data;
+  char **fields;
+  int nfields;
+  int index;
+  int nbytes;
+  int offset;
+  int is_modified;
+};
+
+/* "pysam/TabProxies.pxd":77
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class NamedTupleProxy( TupleProxy) :             # <<<<<<<<<<<<<<
+ *     pass
+ * 
+ */
+
+struct __pyx_obj_10TabProxies_NamedTupleProxy {
+  struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+};
+
+/* "pysam/TabProxies.pxd":80
+ *     pass
+ * 
+ * cdef class BedProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_obj_10TabProxies_BedProxy {
+  struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+  char *contig;
+  uint32_t start;
+  uint32_t end;
+  int bedfields;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":94
+ * ###########################################################################################################
+ * 
+ * cdef class VCFRecord( TabProxies.TupleProxy):             # <<<<<<<<<<<<<<
+ *     '''vcf record.
+ * 
+ */
+
+struct __pyx_obj_4cvcf_VCFRecord {
+  struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+  PyObject *vcf;
+  char *contig;
+  uint32_t pos;
+};
+
+/* "pysam/TabProxies.pxd":91
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class VCFProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_obj_10TabProxies_VCFProxy {
+  struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+  char *contig;
+  uint32_t pos;
+};
+
+/* "pysam/ctabix.pxd":178
+ *     cdef tabix_t * tabixfile
+ * 
+ * cdef class Parser:             # <<<<<<<<<<<<<<
+ *      pass
+ */
+
+struct __pyx_obj_6ctabix_Parser {
+  PyObject_HEAD
+};
+
+/* "pysam/TabProxies.pxd":60
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class GTFProxy( TupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_obj_10TabProxies_GTFProxy {
+  struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+  char *contig;
+  char *source;
+  char *feature;
+  uint32_t start;
+  uint32_t end;
+  char *score;
+  char *strand;
+  char *frame;
+  char *attributes;
+  int hasOwnAttributes;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":221
+ * 
+ * 
+ * cdef class asVCFRecord( ctabix.Parser ):             # <<<<<<<<<<<<<<
+ *     '''converts a :term:`tabix row` into a VCF record.'''
+ *     cdef vcffile
+ */
+
+struct __pyx_obj_4cvcf_asVCFRecord {
+  struct __pyx_obj_6ctabix_Parser __pyx_base;
+  PyObject *vcffile;
+};
+
+/* "pysam/ctabix.pxd":172
+ *   # char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
+ * 
+ * cdef class Tabixfile:             # <<<<<<<<<<<<<<
+ *     cdef char * filename
+ * 
+ */
+
+struct __pyx_obj_6ctabix_Tabixfile {
+  PyObject_HEAD
+  char *filename;
+  tabix_t *tabixfile;
+};
+
+
+/* "pysam/TabProxies.pxd":42
+ *   ctypedef int uint64_t
+ * 
+ * cdef class TupleProxy:             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_TupleProxy {
+  int (*getMaxFields)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t);
+  PyObject *(*take)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+  PyObject *(*present)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+  PyObject *(*copy)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+  PyObject *(*update)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+};
+static struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtabptr_10TabProxies_TupleProxy;
+
+
+/* "pysam/TabProxies.pxd":77
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class NamedTupleProxy( TupleProxy) :             # <<<<<<<<<<<<<<
+ *     pass
+ * 
+ */
+
+struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy {
+  struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+
+
+/* "pysam/TabProxies.pxd":91
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class VCFProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_VCFProxy {
+  struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_VCFProxy *__pyx_vtabptr_10TabProxies_VCFProxy;
+
+
+/* "pysam/TabProxies.pxd":60
+ *     cdef update( self, char * buffer, size_t nbytes )
+ * 
+ * cdef class GTFProxy( TupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_GTFProxy {
+  struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_GTFProxy *__pyx_vtabptr_10TabProxies_GTFProxy;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":94
+ * ###########################################################################################################
+ * 
+ * cdef class VCFRecord( TabProxies.TupleProxy):             # <<<<<<<<<<<<<<
+ *     '''vcf record.
+ * 
+ */
+
+struct __pyx_vtabstruct_4cvcf_VCFRecord {
+  struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_4cvcf_VCFRecord *__pyx_vtabptr_4cvcf_VCFRecord;
+
+
+/* "pysam/TabProxies.pxd":80
+ *     pass
+ * 
+ * cdef class BedProxy( NamedTupleProxy) :             # <<<<<<<<<<<<<<
+ * 
+ *     cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_BedProxy {
+  struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_BedProxy *__pyx_vtabptr_10TabProxies_BedProxy;
+
+#ifndef CYTHON_REFNANNY
+  #define CYTHON_REFNANNY 0
+#endif
+
+#if CYTHON_REFNANNY
+  typedef struct {
+    void (*INCREF)(void*, PyObject*, int);
+    void (*DECREF)(void*, PyObject*, int);
+    void (*GOTREF)(void*, PyObject*, int);
+    void (*GIVEREF)(void*, PyObject*, int);
+    void* (*SetupContext)(const char*, int, const char*);
+    void (*FinishContext)(void**);
+  } __Pyx_RefNannyAPIStruct;
+  static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
+  static __Pyx_RefNannyAPIStruct * __Pyx_RefNannyImportAPI(const char *modname) {
+    PyObject *m = NULL, *p = NULL;
+    void *r = NULL;
+    m = PyImport_ImportModule((char *)modname);
+    if (!m) goto end;
+    p = PyObject_GetAttrString(m, (char *)"RefNannyAPI");
+    if (!p) goto end;
+    r = PyLong_AsVoidPtr(p);
+  end:
+    Py_XDECREF(p);
+    Py_XDECREF(m);
+    return (__Pyx_RefNannyAPIStruct *)r;
+  }
+  #define __Pyx_RefNannySetupContext(name)           void *__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__)
+  #define __Pyx_RefNannyFinishContext()           __Pyx_RefNanny->FinishContext(&__pyx_refnanny)
+  #define __Pyx_INCREF(r) __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+  #define __Pyx_DECREF(r) __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+  #define __Pyx_GOTREF(r) __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+  #define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+  #define __Pyx_XDECREF(r) do { if((r) != NULL) {__Pyx_DECREF(r);} } while(0)
+#else
+  #define __Pyx_RefNannySetupContext(name)
+  #define __Pyx_RefNannyFinishContext()
+  #define __Pyx_INCREF(r) Py_INCREF(r)
+  #define __Pyx_DECREF(r) Py_DECREF(r)
+  #define __Pyx_GOTREF(r)
+  #define __Pyx_GIVEREF(r)
+  #define __Pyx_XDECREF(r) Py_XDECREF(r)
+#endif /* CYTHON_REFNANNY */
+#define __Pyx_XGIVEREF(r) do { if((r) != NULL) {__Pyx_GIVEREF(r);} } while(0)
+#define __Pyx_XGOTREF(r) do { if((r) != NULL) {__Pyx_GOTREF(r);} } while(0)
+
+static PyObject *__Pyx_GetName(PyObject *dict, PyObject *name); /*proto*/
+
+static void __Pyx_RaiseDoubleKeywordsError(
+    const char* func_name, PyObject* kw_name); /*proto*/
+
+static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
+    Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found); /*proto*/
+
+static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[],     PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args,     const char* function_name); /*proto*/
+
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
+    PyObject *r;
+    if (!j) return NULL;
+    r = PyObject_GetItem(o, j);
+    Py_DECREF(j);
+    return r;
+}
+
+
+#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+                                                    __Pyx_GetItemInt_List_Fast(o, i) : \
+                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
+    if (likely(o != Py_None)) {
+        if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+            PyObject *r = PyList_GET_ITEM(o, i);
+            Py_INCREF(r);
+            return r;
+        }
+        else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
+            PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
+            Py_INCREF(r);
+            return r;
+        }
+    }
+    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+                                                    __Pyx_GetItemInt_Tuple_Fast(o, i) : \
+                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
+    if (likely(o != Py_None)) {
+        if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+            PyObject *r = PyTuple_GET_ITEM(o, i);
+            Py_INCREF(r);
+            return r;
+        }
+        else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
+            PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
+            Py_INCREF(r);
+            return r;
+        }
+    }
+    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+
+#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+                                                    __Pyx_GetItemInt_Fast(o, i) : \
+                                                    __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
+    PyObject *r;
+    if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+        r = PyList_GET_ITEM(o, i);
+        Py_INCREF(r);
+    }
+    else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+        r = PyTuple_GET_ITEM(o, i);
+        Py_INCREF(r);
+    }
+    else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
+        r = PySequence_GetItem(o, i);
+    }
+    else {
+        r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+    }
+    return r;
+}
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj); /* proto */
+
+#define __Pyx_PyObject_AsDouble(obj) \
+    ((likely(PyFloat_CheckExact(obj))) ? \
+     PyFloat_AS_DOUBLE(obj) : __Pyx__PyObject_AsDouble(obj))
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
+
+
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
+    PyObject *value;
+    if (unlikely(d == Py_None)) {
+        __Pyx_RaiseNoneIndexingError();
+        return NULL;
+    }
+    value = PyDict_GetItemWithError(d, key);
+    if (unlikely(!value)) {
+        if (!PyErr_Occurred())
+            PyErr_SetObject(PyExc_KeyError, key);
+        return NULL;
+    }
+    Py_INCREF(value);
+    return value;
+}
+#else
+    #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
+#endif
+
+static CYTHON_INLINE long __Pyx_NegateNonNeg(long b) { return unlikely(b < 0) ? b : !b; }
+static CYTHON_INLINE PyObject* __Pyx_PyBoolOrNull_FromLong(long b) {
+    return unlikely(b < 0) ? NULL : __Pyx_PyBool_FromLong(b);
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
+
+static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
+static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
+
+static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t, Py_ssize_t); /* proto */
+
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Append(PyObject* L, PyObject* x) {
+    if (likely(PyList_CheckExact(L))) {
+        if (PyList_Append(L, x) < 0) return NULL;
+        Py_INCREF(Py_None);
+        return Py_None; /* this is just to have an accurate signature */
+    }
+    else {
+        PyObject *r, *m;
+        m = __Pyx_GetAttrString(L, "append");
+        if (!m) return NULL;
+        r = PyObject_CallFunctionObjArgs(m, x, NULL);
+        Py_DECREF(m);
+        return r;
+    }
+}
+
+#define __Pyx_SetItemInt(o, i, v, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+                                                    __Pyx_SetItemInt_Fast(o, i, v) : \
+                                                    __Pyx_SetItemInt_Generic(o, to_py_func(i), v))
+
+static CYTHON_INLINE int __Pyx_SetItemInt_Generic(PyObject *o, PyObject *j, PyObject *v) {
+    int r;
+    if (!j) return -1;
+    r = PyObject_SetItem(o, j, v);
+    Py_DECREF(j);
+    return r;
+}
+
+static CYTHON_INLINE int __Pyx_SetItemInt_Fast(PyObject *o, Py_ssize_t i, PyObject *v) {
+    if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+        Py_INCREF(v);
+        Py_DECREF(PyList_GET_ITEM(o, i));
+        PyList_SET_ITEM(o, i, v);
+        return 1;
+    }
+    else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_ass_item && (likely(i >= 0)))
+        return PySequence_SetItem(o, i, v);
+    else {
+        PyObject *j = PyInt_FromSsize_t(i);
+        return __Pyx_SetItemInt_Generic(o, j, v);
+    }
+}
+
+#if PY_VERSION_HEX < 0x02050000
+#ifndef PyAnySet_CheckExact
+
+#define PyAnySet_CheckExact(ob) \
+    ((ob)->ob_type == &PySet_Type || \
+     (ob)->ob_type == &PyFrozenSet_Type)
+
+#define PySet_New(iterable) \
+    PyObject_CallFunctionObjArgs((PyObject *)&PySet_Type, (iterable), NULL)
+
+#define Pyx_PyFrozenSet_New(iterable) \
+    PyObject_CallFunctionObjArgs((PyObject *)&PyFrozenSet_Type, (iterable), NULL)
+
+#define PySet_Size(anyset) \
+    PyObject_Size((anyset))
+
+#define PySet_Contains(anyset, key) \
+    PySequence_Contains((anyset), (key))
+
+#define PySet_Pop(set) \
+    PyObject_CallMethod(set, (char *)"pop", NULL)
+
+static CYTHON_INLINE int PySet_Clear(PyObject *set) {
+    PyObject *ret = PyObject_CallMethod(set, (char *)"clear", NULL);
+    if (!ret) return -1;
+    Py_DECREF(ret); return 0;
+}
+
+static CYTHON_INLINE int PySet_Discard(PyObject *set, PyObject *key) {
+    PyObject *ret = PyObject_CallMethod(set, (char *)"discard", (char *)"O", key);
+    if (!ret) return -1;
+    Py_DECREF(ret); return 0;
+}
+
+static CYTHON_INLINE int PySet_Add(PyObject *set, PyObject *key) {
+    PyObject *ret = PyObject_CallMethod(set, (char *)"add", (char *)"O", key);
+    if (!ret) return -1;
+    Py_DECREF(ret); return 0;
+}
+
+#endif /* PyAnySet_CheckExact (<= Py2.4) */
+
+#if PY_VERSION_HEX < 0x02040000
+#ifndef Py_SETOBJECT_H
+#define Py_SETOBJECT_H
+
+static PyTypeObject *__Pyx_PySet_Type = NULL;
+static PyTypeObject *__Pyx_PyFrozenSet_Type = NULL;
+
+#define PySet_Type (*__Pyx_PySet_Type)
+#define PyFrozenSet_Type (*__Pyx_PyFrozenSet_Type)
+
+#define PyAnySet_Check(ob) \
+    (PyAnySet_CheckExact(ob) || \
+     PyType_IsSubtype((ob)->ob_type, &PySet_Type) || \
+     PyType_IsSubtype((ob)->ob_type, &PyFrozenSet_Type))
+
+#define PyFrozenSet_CheckExact(ob) ((ob)->ob_type == &PyFrozenSet_Type)
+
+static int __Pyx_Py23SetsImport(void) {
+    PyObject *sets=0, *Set=0, *ImmutableSet=0;
+
+    sets = PyImport_ImportModule((char *)"sets");
+    if (!sets) goto bad;
+    Set = PyObject_GetAttrString(sets, (char *)"Set");
+    if (!Set) goto bad;
+    ImmutableSet = PyObject_GetAttrString(sets, (char *)"ImmutableSet");
+    if (!ImmutableSet) goto bad;
+    Py_DECREF(sets);
+
+    __Pyx_PySet_Type       = (PyTypeObject*) Set;
+    __Pyx_PyFrozenSet_Type = (PyTypeObject*) ImmutableSet;
+
+    return 0;
+
+ bad:
+    Py_XDECREF(sets);
+    Py_XDECREF(Set);
+    Py_XDECREF(ImmutableSet);
+    return -1;
+}
+
+#else
+static int __Pyx_Py23SetsImport(void) { return 0; }
+#endif /* !Py_SETOBJECT_H */
+#endif /* < Py2.4  */
+#endif /* < Py2.5  */
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
+
+static PyObject *__Pyx_CreateClass(PyObject *bases, PyObject *dict, PyObject *name, const char *modname); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t);
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
+
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict);  /*proto*/
+
+static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr); /*proto*/
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable); /*proto*/
+
+static void __Pyx_AddTraceback(const char *funcname); /*proto*/
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
+/* Module declarations from ctabix */
+
+static PyTypeObject *__pyx_ptype_6ctabix_Tabixfile = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_Parser = 0;
+/* Module declarations from TabProxies */
+
+static PyTypeObject *__pyx_ptype_10TabProxies_TupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_GTFProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_NamedTupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_BedProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_VCFProxy = 0;
+/* Module declarations from cvcf */
+
+static PyTypeObject *__pyx_ptype_4cvcf_VCFRecord = 0;
+static PyTypeObject *__pyx_ptype_4cvcf_asVCFRecord = 0;
+#define __Pyx_MODULE_NAME "cvcf"
+int __pyx_module_is_main_cvcf = 0;
+
+/* Implementation of cvcf */
+static PyObject *__pyx_builtin_object;
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_range;
+static PyObject *__pyx_builtin_enumerate;
+static PyObject *__pyx_builtin_map;
+static PyObject *__pyx_builtin_min;
+static PyObject *__pyx_builtin_len;
+static PyObject *__pyx_builtin_zip;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_KeyError;
+static PyObject *__pyx_builtin_NotImplementedError;
+static char __pyx_k_1[] = "";
+static char __pyx_k_2[] = ",";
+static char __pyx_k_3[] = ":";
+static char __pyx_k_4[] = "-";
+static char __pyx_k_5[] = "Don't understand region string '%s'";
+static char __pyx_k_6[] = ".";
+static char __pyx_k_7[] = ";";
+static char __pyx_k_8[] = "=";
+static char __pyx_k_9[] = "BAD_NUMBER_OF_VALUES";
+static char __pyx_k_10[] = "(found %s values in element %s; expected %s)";
+static char __pyx_k_11[] = "BAD_NUMBER_OF_PARAMETERS";
+static char __pyx_k_12[] = "id=%s, expected %s parameters, got %s";
+static char __pyx_k_14[] = "Line %s: '%s'\n%s %s: %s\n";
+static char __pyx_k_16[] = "<";
+static char __pyx_k_17[] = "V40_MISSING_ANGLE_BRACKETS";
+static char __pyx_k_18[] = ">";
+static char __pyx_k_19[] = "\"";
+static char __pyx_k_20[] = "V40_FORMAT_MUST_HAVE_NAMED_FIELDS";
+static char __pyx_k_21[] = "BADLY_FORMATTED_FORMAT_STRING";
+static char __pyx_k_22[] = "ID=";
+static char __pyx_k_23[] = "Number=";
+static char __pyx_k_24[] = "Type=";
+static char __pyx_k_25[] = "Description=";
+static char __pyx_k_26[] = "FORMAT_MISSING_QUOTES";
+static char __pyx_k_27[] = "<none>";
+static char __pyx_k_28[] = "#alleles";
+static char __pyx_k_29[] = "#nonref_alleles";
+static char __pyx_k_30[] = "#genotypes";
+static char __pyx_k_31[] = "#phased_genotypes";
+static char __pyx_k_33[] = "Unknown number type encountered: %s";
+static char __pyx_k_34[] = "%s=%s";
+static char __pyx_k_35[] = "(Undefined tag)";
+static char __pyx_k_38[] = "(output)";
+static char __pyx_k_39[] = "Genotype Quality";
+static char __pyx_k_40[] = "Read depth at this position for this sample";
+static char __pyx_k_41[] = "Haplotype Quality";
+static char __pyx_k_42[] = "Sample Genotype Filter";
+static char __pyx_k_43[] = "##";
+static char __pyx_k_44[] = "VCFv3.3";
+static char __pyx_k_45[] = "VCFv4.0";
+static char __pyx_k_46[] = "VCFv4.1";
+static char __pyx_k_47[] = "UNKNOWN_FORMAT_STRING";
+static char __pyx_k_48[] = "##fileformat=VCFv%s.%s\n";
+static char __pyx_k_49[] = "##%s=%s\n";
+static char __pyx_k_50[] = "#";
+static char __pyx_k_51[] = "\t";
+static char __pyx_k_52[] = "HEADING_NOT_SEPARATED_BY_TABS";
+static char __pyx_k_53[] = "(%sth entry not found)";
+static char __pyx_k_54[] = "(found %s, expected %s)";
+static char __pyx_k_55[] = "BADLY_FORMATTED_HEADING";
+static char __pyx_k_56[] = "\n";
+static char __pyx_k_57[] = "|";
+static char __pyx_k_58[] = "ERROR_FLAG_HAS_VALUE";
+static char __pyx_k_59[] = "ERROR_FORMAT_NOT_NUMERICAL";
+static char __pyx_k_60[] = "ERROR_FORMAT_NOT_CHAR";
+static char __pyx_k_62[] = "BAD_NUMBER_OF_COLUMNS";
+static char __pyx_k_63[] = "expected %s for %s samples (%s), got %s";
+static char __pyx_k_64[] = "(reference is %s, VCF says %s)";
+static char __pyx_k_65[] = "V33_UNMATCHED_DELETION";
+static char __pyx_k_66[] = "(deletion is %s, reference is %s)";
+static char __pyx_k_67[] = "MISSING_INDEL_ALLELE_REF_BASE";
+static char __pyx_k_68[] = "Required key %s not found in data";
+static char __pyx_k_69[] = "enter_default_format";
+static char __pyx_k_70[] = "Can only handle v3.3 and v4.0 VCF files";
+static char __pyx_k_71[] = "Invalid error string: %s";
+static char __pyx_k_72[] = "needs to be checked";
+static char __pyx_k_73[] = "[|/\\\\]";
+static char __pyx_k_74[] = "^[ACGTN]+$";
+static char __pyx_k_75[] = "id numbertype number type description missingvalue";
+static char __pyx_k_76[] = "UNKNOWN_FORMAT_STRING:Unknown file format identifier";
+static char __pyx_k_77[] = "BADLY_FORMATTED_FORMAT_STRING:Formatting error in the format string";
+static char __pyx_k_78[] = "BADLY_FORMATTED_HEADING:Did not find 9 required headings (CHROM, POS, ..., FORMAT) %s";
+static char __pyx_k_79[] = "BAD_NUMBER_OF_COLUMNS:Wrong number of columns found (%s)";
+static char __pyx_k_80[] = "POS_NOT_NUMERICAL:Position column is not numerical";
+static char __pyx_k_81[] = "UNKNOWN_CHAR_IN_REF:Unknown character in reference field";
+static char __pyx_k_82[] = "V33_BAD_REF:Reference should be single-character in v3.3 VCF";
+static char __pyx_k_83[] = "V33_BAD_ALLELE:Cannot interpret allele for v3.3 VCF";
+static char __pyx_k_84[] = "POS_NOT_POSITIVE:Position field must be >0";
+static char __pyx_k_85[] = "QUAL_NOT_NUMERICAL:Quality field must be numerical, or '.'";
+static char __pyx_k_86[] = "ERROR_INFO_STRING:Error while parsing info field";
+static char __pyx_k_87[] = "ERROR_UNKNOWN_KEY:Unknown key (%s) found in formatted field (info; format; or filter)";
+static char __pyx_k_88[] = "ERROR_FORMAT_NOT_NUMERICAL:Expected integer or float in formatted field; got %s";
+static char __pyx_k_89[] = "ERROR_FORMAT_NOT_CHAR:Eexpected character in formatted field; got string";
+static char __pyx_k_90[] = "FILTER_NOT_DEFINED:Identifier (%s) in filter found which was not defined in header";
+static char __pyx_k_91[] = "FORMAT_NOT_DEFINED:Identifier (%s) in format found which was not defined in header";
+static char __pyx_k_92[] = "BAD_NUMBER_OF_VALUES:Found too many of values in sample column (%s)";
+static char __pyx_k_93[] = "BAD_NUMBER_OF_PARAMETERS:Found unexpected number of parameters (%s)";
+static char __pyx_k_94[] = "BAD_GENOTYPE:Cannot parse genotype (%s)";
+static char __pyx_k_95[] = "V40_BAD_ALLELE:Bad allele found for v4.0 VCF (%s)";
+static char __pyx_k_96[] = "MISSING_REF:Reference allele missing";
+static char __pyx_k_97[] = "V33_UNMATCHED_DELETION:Deleted sequence does not match reference (%s)";
+static char __pyx_k_98[] = "V40_MISSING_ANGLE_BRACKETS:Format definition is not deliminted by angular brackets";
+static char __pyx_k_99[] = "FORMAT_MISSING_QUOTES:Description field in format definition is not surrounded by quotes";
+static char __pyx_k__0[] = "0";
+static char __pyx_k__D[] = "D";
+static char __pyx_k__I[] = "I";
+static char __pyx_k__N[] = "N";
+static char __pyx_k_100[] = "V40_FORMAT_MUST_HAVE_NAMED_FIELDS:Fields in v4.0 VCF format definition must have named fields";
+static char __pyx_k_101[] = "HEADING_NOT_SEPARATED_BY_TABS:Heading line appears separated by spaces, not tabs";
+static char __pyx_k_102[] = "WRONG_REF:Wrong reference %s";
+static char __pyx_k_103[] = "ERROR_TRAILING_DATA:Numerical field ('%s') has semicolon-separated trailing data";
+static char __pyx_k_104[] = "BAD_CHR_TAG:Error calculating chr tag for %s";
+static char __pyx_k_105[] = "ZERO_LENGTH_ALLELE:Found zero-length allele";
+static char __pyx_k_106[] = "MISSING_INDEL_ALLELE_REF_BASE:Indel alleles must begin with single reference base";
+static char __pyx_k_107[] = "VCF.getsamples (line 880)";
+static char __pyx_k_108[] = "VCF.setsamples (line 884)";
+static char __pyx_k_109[] = "VCF.getheader (line 888)";
+static char __pyx_k_110[] = "VCF.setheader (line 892)";
+static char __pyx_k_111[] = "VCF.getinfo (line 896)";
+static char __pyx_k_112[] = "VCF.setinfo (line 900)";
+static char __pyx_k_113[] = "VCF.getformat (line 904)";
+static char __pyx_k_114[] = "VCF.setformat (line 908)";
+static char __pyx_k_115[] = "VCF.getfilter (line 912)";
+static char __pyx_k_116[] = "VCF.setfilter (line 916)";
+static char __pyx_k_117[] = "VCF.setreference (line 927)";
+static char __pyx_k_118[] = "VCF.parse (line 939)";
+static char __pyx_k_119[] = "VCF.write (line 946)";
+static char __pyx_k_120[] = "VCF.writeheader (line 952)";
+static char __pyx_k_121[] = "VCF.compare_calls (line 957)";
+static char __pyx_k_122[] = "VCF.connect (line 979)";
+static char __pyx_k_123[] = "VCF.fetch (line 984)";
+static char __pyx_k_124[] = "VCF.validate (line 993)";
+static char __pyx_k__DP[] = "DP";
+static char __pyx_k__FT[] = "FT";
+static char __pyx_k__GQ[] = "GQ";
+static char __pyx_k__GT[] = "GT";
+static char __pyx_k__HQ[] = "HQ";
+static char __pyx_k__ID[] = "ID";
+static char __pyx_k__fa[] = "fa";
+static char __pyx_k__id[] = "id";
+static char __pyx_k__re[] = "re";
+static char __pyx_k__ALT[] = "ALT";
+static char __pyx_k__POS[] = "POS";
+static char __pyx_k__REF[] = "REF";
+static char __pyx_k__VCF[] = "VCF";
+static char __pyx_k__add[] = "add";
+static char __pyx_k__alt[] = "alt";
+static char __pyx_k__end[] = "end";
+static char __pyx_k__fmt[] = "fmt";
+static char __pyx_k__get[] = "get";
+static char __pyx_k__key[] = "key";
+static char __pyx_k__len[] = "len";
+static char __pyx_k__map[] = "map";
+static char __pyx_k__min[] = "min";
+static char __pyx_k__opt[] = "opt";
+static char __pyx_k__pos[] = "pos";
+static char __pyx_k__ref[] = "ref";
+static char __pyx_k__sys[] = "sys";
+static char __pyx_k__vcf[] = "vcf";
+static char __pyx_k__zip[] = "zip";
+static char __pyx_k__Flag[] = "Flag";
+static char __pyx_k__INFO[] = "INFO";
+static char __pyx_k__PASS[] = "PASS";
+static char __pyx_k__QUAL[] = "QUAL";
+static char __pyx_k__Type[] = "Type";
+static char __pyx_k__alt1[] = "alt1";
+static char __pyx_k__alt2[] = "alt2";
+static char __pyx_k__copy[] = "copy";
+static char __pyx_k__data[] = "data";
+static char __pyx_k__find[] = "find";
+static char __pyx_k__info[] = "info";
+static char __pyx_k__join[] = "join";
+static char __pyx_k__keys[] = "keys";
+static char __pyx_k__line[] = "line";
+static char __pyx_k__pos1[] = "pos1";
+static char __pyx_k__pos2[] = "pos2";
+static char __pyx_k__qual[] = "qual";
+static char __pyx_k__ref1[] = "ref1";
+static char __pyx_k__ref2[] = "ref2";
+static char __pyx_k__self[] = "self";
+static char __pyx_k__type[] = "type";
+static char __pyx_k__ACGTN[] = "ACGTN";
+static char __pyx_k__CHROM[] = "CHROM";
+static char __pyx_k__Error[] = "Error";
+static char __pyx_k__Float[] = "Float";
+static char __pyx_k___copy[] = "_copy";
+static char __pyx_k___info[] = "_info";
+static char __pyx_k___line[] = "_line";
+static char __pyx_k__chrom[] = "chrom";
+static char __pyx_k__descr[] = "descr";
+static char __pyx_k__error[] = "error";
+static char __pyx_k__fetch[] = "fetch";
+static char __pyx_k__lines[] = "lines";
+static char __pyx_k__match[] = "match";
+static char __pyx_k__parse[] = "parse";
+static char __pyx_k__pysam[] = "pysam";
+static char __pyx_k__range[] = "range";
+static char __pyx_k__split[] = "split";
+static char __pyx_k__start[] = "start";
+static char __pyx_k__strip[] = "strip";
+static char __pyx_k__upper[] = "upper";
+static char __pyx_k__value[] = "value";
+static char __pyx_k__write[] = "write";
+static char __pyx_k__FILTER[] = "FILTER";
+static char __pyx_k__FORMAT[] = "FORMAT";
+static char __pyx_k__GTdata[] = "GTdata";
+static char __pyx_k__Number[] = "Number";
+static char __pyx_k__String[] = "String";
+static char __pyx_k___lines[] = "_lines";
+static char __pyx_k___parse[] = "_parse";
+static char __pyx_k__bisect[] = "bisect";
+static char __pyx_k__buffer[] = "buffer";
+static char __pyx_k__contig[] = "contig";
+static char __pyx_k__fields[] = "fields";
+static char __pyx_k__filter[] = "filter";
+static char __pyx_k__format[] = "format";
+static char __pyx_k__header[] = "header";
+static char __pyx_k__number[] = "number";
+static char __pyx_k__object[] = "object";
+static char __pyx_k__offset[] = "offset";
+static char __pyx_k__parser[] = "parser";
+static char __pyx_k__record[] = "record";
+static char __pyx_k__region[] = "region";
+static char __pyx_k__stderr[] = "stderr";
+static char __pyx_k__stream[] = "stream";
+static char __pyx_k__Integer[] = "Integer";
+static char __pyx_k__Warning[] = "Warning";
+static char __pyx_k____all__[] = "__all__";
+static char __pyx_k___errors[] = "_errors";
+static char __pyx_k___filter[] = "_filter";
+static char __pyx_k___format[] = "_format";
+static char __pyx_k___header[] = "_header";
+static char __pyx_k___lineno[] = "_lineno";
+static char __pyx_k__compile[] = "compile";
+static char __pyx_k__connect[] = "connect";
+static char __pyx_k__getinfo[] = "getinfo";
+static char __pyx_k__missing[] = "missing";
+static char __pyx_k__nfields[] = "nfields";
+static char __pyx_k__regions[] = "regions";
+static char __pyx_k__replace[] = "replace";
+static char __pyx_k__samples[] = "samples";
+static char __pyx_k__setinfo[] = "setinfo";
+static char __pyx_k__vcffile[] = "vcffile";
+static char __pyx_k__version[] = "version";
+static char __pyx_k__GTstring[] = "GTstring";
+static char __pyx_k__Genotype[] = "Genotype";
+static char __pyx_k__KeyError[] = "KeyError";
+static char __pyx_k____dict__[] = "__dict__";
+static char __pyx_k____init__[] = "__init__";
+static char __pyx_k____main__[] = "__main__";
+static char __pyx_k____test__[] = "__test__";
+static char __pyx_k___regions[] = "_regions";
+static char __pyx_k___samples[] = "_samples";
+static char __pyx_k___version[] = "_version";
+static char __pyx_k__deepcopy[] = "deepcopy";
+static char __pyx_k__endswith[] = "endswith";
+static char __pyx_k__filename[] = "filename";
+static char __pyx_k__gtsRegEx[] = "gtsRegEx";
+static char __pyx_k__inregion[] = "inregion";
+static char __pyx_k__operator[] = "operator";
+static char __pyx_k__validate[] = "validate";
+static char __pyx_k__Character[] = "Character";
+static char __pyx_k__NT_NUMBER[] = "NT_NUMBER";
+static char __pyx_k__Tabixfile[] = "Tabixfile";
+static char __pyx_k__VCFRecord[] = "VCFRecord";
+static char __pyx_k__WRONG_REF[] = "WRONG_REF";
+static char __pyx_k___required[] = "_required";
+static char __pyx_k__convertGT[] = "convertGT";
+static char __pyx_k__enumerate[] = "enumerate";
+static char __pyx_k__getfilter[] = "getfilter";
+static char __pyx_k__getformat[] = "getformat";
+static char __pyx_k__getheader[] = "getheader";
+static char __pyx_k__leftalign[] = "leftalign";
+static char __pyx_k__lineparse[] = "lineparse";
+static char __pyx_k__reference[] = "reference";
+static char __pyx_k__separator[] = "separator";
+static char __pyx_k__setfilter[] = "setfilter";
+static char __pyx_k__setformat[] = "setformat";
+static char __pyx_k__setheader[] = "setheader";
+static char __pyx_k__tabixfile[] = "tabixfile";
+static char __pyx_k__warnerror[] = "warnerror";
+static char __pyx_k__NT_ALLELES[] = "NT_ALLELES";
+static char __pyx_k__NT_UNKNOWN[] = "NT_UNKNOWN";
+static char __pyx_k__ValueError[] = "ValueError";
+static char __pyx_k___leftalign[] = "_leftalign";
+static char __pyx_k___reference[] = "_reference";
+static char __pyx_k__fileformat[] = "fileformat";
+static char __pyx_k__formatdict[] = "formatdict";
+static char __pyx_k__getsamples[] = "getsamples";
+static char __pyx_k__itemgetter[] = "itemgetter";
+static char __pyx_k__itervalues[] = "itervalues";
+static char __pyx_k__namedtuple[] = "namedtuple";
+static char __pyx_k__numbertype[] = "numbertype";
+static char __pyx_k__parse_data[] = "parse_data";
+static char __pyx_k__setregions[] = "setregions";
+static char __pyx_k__setsamples[] = "setsamples";
+static char __pyx_k__setversion[] = "setversion";
+static char __pyx_k__startswith[] = "startswith";
+static char __pyx_k__write_data[] = "write_data";
+static char __pyx_k__Description[] = "Description";
+static char __pyx_k__MISSING_REF[] = "MISSING_REF";
+static char __pyx_k__V33_BAD_REF[] = "V33_BAD_REF";
+static char __pyx_k__alleleRegEx[] = "alleleRegEx";
+static char __pyx_k__collections[] = "collections";
+static char __pyx_k__defaultdict[] = "defaultdict";
+static char __pyx_k__description[] = "description";
+static char __pyx_k__errorstring[] = "errorstring";
+static char __pyx_k__ignoreerror[] = "ignoreerror";
+static char __pyx_k__writeheader[] = "writeheader";
+static char __pyx_k__BAD_GENOTYPE[] = "BAD_GENOTYPE";
+static char __pyx_k__NT_GENOTYPES[] = "NT_GENOTYPES";
+static char __pyx_k___warn_errors[] = "_warn_errors";
+static char __pyx_k__get_expected[] = "get_expected";
+static char __pyx_k__get_sequence[] = "get_sequence";
+static char __pyx_k__missingvalue[] = "missingvalue";
+static char __pyx_k__parse_format[] = "parse_format";
+static char __pyx_k__parse_header[] = "parse_header";
+static char __pyx_k__setreference[] = "setreference";
+static char __pyx_k__write_header[] = "write_header";
+static char __pyx_k__NT_NR_ALLELES[] = "NT_NR_ALLELES";
+static char __pyx_k__StopIteration[] = "StopIteration";
+static char __pyx_k___parse_header[] = "_parse_header";
+static char __pyx_k__compare_calls[] = "compare_calls";
+static char __pyx_k__convertGTback[] = "convertGTback";
+static char __pyx_k__datagenerator[] = "datagenerator";
+static char __pyx_k__format_format[] = "format_format";
+static char __pyx_k__parse_heading[] = "parse_heading";
+static char __pyx_k__write_heading[] = "write_heading";
+static char __pyx_k__V33_BAD_ALLELE[] = "V33_BAD_ALLELE";
+static char __pyx_k__V40_BAD_ALLELE[] = "V40_BAD_ALLELE";
+static char __pyx_k___sample2column[] = "_sample2column";
+static char __pyx_k___add_definition[] = "_add_definition";
+static char __pyx_k___ignored_errors[] = "_ignored_errors";
+static char __pyx_k__POS_NOT_POSITIVE[] = "POS_NOT_POSITIVE";
+static char __pyx_k__parse_formatdata[] = "parse_formatdata";
+static char __pyx_k__ERROR_INFO_STRING[] = "ERROR_INFO_STRING";
+static char __pyx_k__ERROR_UNKNOWN_KEY[] = "ERROR_UNKNOWN_KEY";
+static char __pyx_k__POS_NOT_NUMERICAL[] = "POS_NOT_NUMERICAL";
+static char __pyx_k__format_formatdata[] = "format_formatdata";
+static char __pyx_k__FILTER_NOT_DEFINED[] = "FILTER_NOT_DEFINED";
+static char __pyx_k__FORMAT_NOT_DEFINED[] = "FORMAT_NOT_DEFINED";
+static char __pyx_k__QUAL_NOT_NUMERICAL[] = "QUAL_NOT_NUMERICAL";
+static char __pyx_k__ZERO_LENGTH_ALLELE[] = "ZERO_LENGTH_ALLELE";
+static char __pyx_k__ERROR_TRAILING_DATA[] = "ERROR_TRAILING_DATA";
+static char __pyx_k__NT_PHASED_GENOTYPES[] = "NT_PHASED_GENOTYPES";
+static char __pyx_k__NotImplementedError[] = "NotImplementedError";
+static char __pyx_k__UNKNOWN_CHAR_IN_REF[] = "UNKNOWN_CHAR_IN_REF";
+static PyObject *__pyx_kp_s_1;
+static PyObject *__pyx_kp_s_10;
+static PyObject *__pyx_kp_s_100;
+static PyObject *__pyx_kp_s_101;
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+static PyObject *__pyx_kp_s_103;
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+static PyObject *__pyx_kp_u_107;
+static PyObject *__pyx_kp_u_108;
+static PyObject *__pyx_kp_u_109;
+static PyObject *__pyx_n_s_11;
+static PyObject *__pyx_kp_u_110;
+static PyObject *__pyx_kp_u_111;
+static PyObject *__pyx_kp_u_112;
+static PyObject *__pyx_kp_u_113;
+static PyObject *__pyx_kp_u_114;
+static PyObject *__pyx_kp_u_115;
+static PyObject *__pyx_kp_u_116;
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+static PyObject *__pyx_kp_u_118;
+static PyObject *__pyx_kp_u_119;
+static PyObject *__pyx_kp_s_12;
+static PyObject *__pyx_kp_u_120;
+static PyObject *__pyx_kp_u_121;
+static PyObject *__pyx_kp_u_122;
+static PyObject *__pyx_kp_u_123;
+static PyObject *__pyx_kp_u_124;
+static PyObject *__pyx_kp_s_14;
+static PyObject *__pyx_kp_s_16;
+static PyObject *__pyx_n_s_17;
+static PyObject *__pyx_kp_s_18;
+static PyObject *__pyx_kp_s_19;
+static PyObject *__pyx_kp_s_2;
+static PyObject *__pyx_n_s_20;
+static PyObject *__pyx_n_s_21;
+static PyObject *__pyx_kp_s_22;
+static PyObject *__pyx_kp_s_23;
+static PyObject *__pyx_kp_s_24;
+static PyObject *__pyx_kp_s_25;
+static PyObject *__pyx_n_s_26;
+static PyObject *__pyx_kp_s_27;
+static PyObject *__pyx_kp_s_28;
+static PyObject *__pyx_kp_s_29;
+static PyObject *__pyx_kp_s_3;
+static PyObject *__pyx_kp_s_30;
+static PyObject *__pyx_kp_s_31;
+static PyObject *__pyx_kp_s_33;
+static PyObject *__pyx_kp_s_34;
+static PyObject *__pyx_kp_s_35;
+static PyObject *__pyx_kp_s_38;
+static PyObject *__pyx_kp_s_39;
+static PyObject *__pyx_kp_s_4;
+static PyObject *__pyx_kp_s_40;
+static PyObject *__pyx_kp_s_41;
+static PyObject *__pyx_kp_s_42;
+static PyObject *__pyx_kp_s_43;
+static PyObject *__pyx_kp_s_44;
+static PyObject *__pyx_kp_s_45;
+static PyObject *__pyx_kp_s_46;
+static PyObject *__pyx_n_s_47;
+static PyObject *__pyx_kp_s_48;
+static PyObject *__pyx_kp_s_49;
+static PyObject *__pyx_kp_s_5;
+static PyObject *__pyx_kp_s_50;
+static PyObject *__pyx_kp_s_51;
+static PyObject *__pyx_n_s_52;
+static PyObject *__pyx_kp_s_53;
+static PyObject *__pyx_kp_s_54;
+static PyObject *__pyx_n_s_55;
+static PyObject *__pyx_kp_s_56;
+static PyObject *__pyx_kp_s_57;
+static PyObject *__pyx_n_s_58;
+static PyObject *__pyx_n_s_59;
+static PyObject *__pyx_kp_b_6;
+static PyObject *__pyx_kp_s_6;
+static PyObject *__pyx_n_s_60;
+static PyObject *__pyx_n_s_62;
+static PyObject *__pyx_kp_s_63;
+static PyObject *__pyx_kp_s_64;
+static PyObject *__pyx_n_s_65;
+static PyObject *__pyx_kp_s_66;
+static PyObject *__pyx_n_s_67;
+static PyObject *__pyx_kp_s_68;
+static PyObject *__pyx_n_s_69;
+static PyObject *__pyx_kp_s_7;
+static PyObject *__pyx_kp_s_70;
+static PyObject *__pyx_kp_s_71;
+static PyObject *__pyx_kp_s_72;
+static PyObject *__pyx_kp_s_73;
+static PyObject *__pyx_kp_s_74;
+static PyObject *__pyx_kp_s_75;
+static PyObject *__pyx_kp_s_76;
+static PyObject *__pyx_kp_s_77;
+static PyObject *__pyx_kp_s_78;
+static PyObject *__pyx_kp_s_79;
+static PyObject *__pyx_kp_s_8;
+static PyObject *__pyx_kp_s_80;
+static PyObject *__pyx_kp_s_81;
+static PyObject *__pyx_kp_s_82;
+static PyObject *__pyx_kp_s_83;
+static PyObject *__pyx_kp_s_84;
+static PyObject *__pyx_kp_s_85;
+static PyObject *__pyx_kp_s_86;
+static PyObject *__pyx_kp_s_87;
+static PyObject *__pyx_kp_s_88;
+static PyObject *__pyx_kp_s_89;
+static PyObject *__pyx_n_s_9;
+static PyObject *__pyx_kp_s_90;
+static PyObject *__pyx_kp_s_91;
+static PyObject *__pyx_kp_s_92;
+static PyObject *__pyx_kp_s_93;
+static PyObject *__pyx_kp_s_94;
+static PyObject *__pyx_kp_s_95;
+static PyObject *__pyx_kp_s_96;
+static PyObject *__pyx_kp_s_97;
+static PyObject *__pyx_kp_s_98;
+static PyObject *__pyx_kp_s_99;
+static PyObject *__pyx_kp_s__0;
+static PyObject *__pyx_n_s__ACGTN;
+static PyObject *__pyx_n_s__ALT;
+static PyObject *__pyx_n_s__BAD_GENOTYPE;
+static PyObject *__pyx_n_s__CHROM;
+static PyObject *__pyx_n_s__Character;
+static PyObject *__pyx_n_s__D;
+static PyObject *__pyx_n_s__DP;
+static PyObject *__pyx_n_s__Description;
+static PyObject *__pyx_n_s__ERROR_INFO_STRING;
+static PyObject *__pyx_n_s__ERROR_TRAILING_DATA;
+static PyObject *__pyx_n_s__ERROR_UNKNOWN_KEY;
+static PyObject *__pyx_n_s__Error;
+static PyObject *__pyx_n_s__FILTER;
+static PyObject *__pyx_n_s__FILTER_NOT_DEFINED;
+static PyObject *__pyx_n_s__FORMAT;
+static PyObject *__pyx_n_s__FORMAT_NOT_DEFINED;
+static PyObject *__pyx_n_s__FT;
+static PyObject *__pyx_n_s__Flag;
+static PyObject *__pyx_n_s__Float;
+static PyObject *__pyx_n_s__GQ;
+static PyObject *__pyx_n_s__GT;
+static PyObject *__pyx_n_s__GTdata;
+static PyObject *__pyx_n_s__GTstring;
+static PyObject *__pyx_n_s__Genotype;
+static PyObject *__pyx_n_s__HQ;
+static PyObject *__pyx_n_s__I;
+static PyObject *__pyx_n_s__ID;
+static PyObject *__pyx_n_s__INFO;
+static PyObject *__pyx_n_s__Integer;
+static PyObject *__pyx_n_s__KeyError;
+static PyObject *__pyx_n_s__MISSING_REF;
+static PyObject *__pyx_n_s__N;
+static PyObject *__pyx_n_s__NT_ALLELES;
+static PyObject *__pyx_n_s__NT_GENOTYPES;
+static PyObject *__pyx_n_s__NT_NR_ALLELES;
+static PyObject *__pyx_n_s__NT_NUMBER;
+static PyObject *__pyx_n_s__NT_PHASED_GENOTYPES;
+static PyObject *__pyx_n_s__NT_UNKNOWN;
+static PyObject *__pyx_n_s__NotImplementedError;
+static PyObject *__pyx_n_s__Number;
+static PyObject *__pyx_n_s__PASS;
+static PyObject *__pyx_n_s__POS;
+static PyObject *__pyx_n_s__POS_NOT_NUMERICAL;
+static PyObject *__pyx_n_s__POS_NOT_POSITIVE;
+static PyObject *__pyx_n_s__QUAL;
+static PyObject *__pyx_n_s__QUAL_NOT_NUMERICAL;
+static PyObject *__pyx_n_s__REF;
+static PyObject *__pyx_n_s__StopIteration;
+static PyObject *__pyx_n_s__String;
+static PyObject *__pyx_n_s__Tabixfile;
+static PyObject *__pyx_n_s__Type;
+static PyObject *__pyx_n_s__UNKNOWN_CHAR_IN_REF;
+static PyObject *__pyx_n_s__V33_BAD_ALLELE;
+static PyObject *__pyx_n_s__V33_BAD_REF;
+static PyObject *__pyx_n_s__V40_BAD_ALLELE;
+static PyObject *__pyx_n_s__VCF;
+static PyObject *__pyx_n_s__VCFRecord;
+static PyObject *__pyx_n_s__ValueError;
+static PyObject *__pyx_n_s__WRONG_REF;
+static PyObject *__pyx_n_s__Warning;
+static PyObject *__pyx_n_s__ZERO_LENGTH_ALLELE;
+static PyObject *__pyx_n_s____all__;
+static PyObject *__pyx_n_s____dict__;
+static PyObject *__pyx_n_s____init__;
+static PyObject *__pyx_n_s____main__;
+static PyObject *__pyx_n_s____test__;
+static PyObject *__pyx_n_s___add_definition;
+static PyObject *__pyx_n_s___copy;
+static PyObject *__pyx_n_s___errors;
+static PyObject *__pyx_n_s___filter;
+static PyObject *__pyx_n_s___format;
+static PyObject *__pyx_n_s___header;
+static PyObject *__pyx_n_s___ignored_errors;
+static PyObject *__pyx_n_s___info;
+static PyObject *__pyx_n_s___leftalign;
+static PyObject *__pyx_n_s___line;
+static PyObject *__pyx_n_s___lineno;
+static PyObject *__pyx_n_s___lines;
+static PyObject *__pyx_n_s___parse;
+static PyObject *__pyx_n_s___parse_header;
+static PyObject *__pyx_n_s___reference;
+static PyObject *__pyx_n_s___regions;
+static PyObject *__pyx_n_s___required;
+static PyObject *__pyx_n_s___sample2column;
+static PyObject *__pyx_n_s___samples;
+static PyObject *__pyx_n_s___version;
+static PyObject *__pyx_n_s___warn_errors;
+static PyObject *__pyx_n_s__add;
+static PyObject *__pyx_n_s__alleleRegEx;
+static PyObject *__pyx_n_s__alt;
+static PyObject *__pyx_n_s__alt1;
+static PyObject *__pyx_n_s__alt2;
+static PyObject *__pyx_n_s__bisect;
+static PyObject *__pyx_n_s__buffer;
+static PyObject *__pyx_n_s__chrom;
+static PyObject *__pyx_n_s__collections;
+static PyObject *__pyx_n_s__compare_calls;
+static PyObject *__pyx_n_s__compile;
+static PyObject *__pyx_n_s__connect;
+static PyObject *__pyx_n_s__contig;
+static PyObject *__pyx_n_s__convertGT;
+static PyObject *__pyx_n_s__convertGTback;
+static PyObject *__pyx_n_s__copy;
+static PyObject *__pyx_n_s__data;
+static PyObject *__pyx_n_s__datagenerator;
+static PyObject *__pyx_n_s__deepcopy;
+static PyObject *__pyx_n_s__defaultdict;
+static PyObject *__pyx_n_s__descr;
+static PyObject *__pyx_n_s__description;
+static PyObject *__pyx_n_s__end;
+static PyObject *__pyx_n_s__endswith;
+static PyObject *__pyx_n_s__enumerate;
+static PyObject *__pyx_n_s__error;
+static PyObject *__pyx_n_s__errorstring;
+static PyObject *__pyx_n_s__fa;
+static PyObject *__pyx_n_s__fetch;
+static PyObject *__pyx_n_s__fields;
+static PyObject *__pyx_n_s__fileformat;
+static PyObject *__pyx_n_s__filename;
+static PyObject *__pyx_n_s__filter;
+static PyObject *__pyx_n_s__find;
+static PyObject *__pyx_n_s__fmt;
+static PyObject *__pyx_n_s__format;
+static PyObject *__pyx_n_s__format_format;
+static PyObject *__pyx_n_s__format_formatdata;
+static PyObject *__pyx_n_s__formatdict;
+static PyObject *__pyx_n_s__get;
+static PyObject *__pyx_n_s__get_expected;
+static PyObject *__pyx_n_s__get_sequence;
+static PyObject *__pyx_n_s__getfilter;
+static PyObject *__pyx_n_s__getformat;
+static PyObject *__pyx_n_s__getheader;
+static PyObject *__pyx_n_s__getinfo;
+static PyObject *__pyx_n_s__getsamples;
+static PyObject *__pyx_n_s__gtsRegEx;
+static PyObject *__pyx_n_s__header;
+static PyObject *__pyx_n_s__id;
+static PyObject *__pyx_n_s__ignoreerror;
+static PyObject *__pyx_n_s__info;
+static PyObject *__pyx_n_s__inregion;
+static PyObject *__pyx_n_s__itemgetter;
+static PyObject *__pyx_n_s__itervalues;
+static PyObject *__pyx_n_s__join;
+static PyObject *__pyx_n_s__key;
+static PyObject *__pyx_n_s__keys;
+static PyObject *__pyx_n_s__leftalign;
+static PyObject *__pyx_n_s__len;
+static PyObject *__pyx_n_s__line;
+static PyObject *__pyx_n_s__lineparse;
+static PyObject *__pyx_n_s__lines;
+static PyObject *__pyx_n_s__map;
+static PyObject *__pyx_n_s__match;
+static PyObject *__pyx_n_s__min;
+static PyObject *__pyx_n_s__missing;
+static PyObject *__pyx_n_s__missingvalue;
+static PyObject *__pyx_n_s__namedtuple;
+static PyObject *__pyx_n_s__nfields;
+static PyObject *__pyx_n_s__number;
+static PyObject *__pyx_n_s__numbertype;
+static PyObject *__pyx_n_s__object;
+static PyObject *__pyx_n_s__offset;
+static PyObject *__pyx_n_s__operator;
+static PyObject *__pyx_n_s__opt;
+static PyObject *__pyx_n_s__parse;
+static PyObject *__pyx_n_s__parse_data;
+static PyObject *__pyx_n_s__parse_format;
+static PyObject *__pyx_n_s__parse_formatdata;
+static PyObject *__pyx_n_s__parse_header;
+static PyObject *__pyx_n_s__parse_heading;
+static PyObject *__pyx_n_s__parser;
+static PyObject *__pyx_n_s__pos;
+static PyObject *__pyx_n_s__pos1;
+static PyObject *__pyx_n_s__pos2;
+static PyObject *__pyx_n_s__pysam;
+static PyObject *__pyx_n_s__qual;
+static PyObject *__pyx_n_s__range;
+static PyObject *__pyx_n_s__re;
+static PyObject *__pyx_n_s__record;
+static PyObject *__pyx_n_s__ref;
+static PyObject *__pyx_n_s__ref1;
+static PyObject *__pyx_n_s__ref2;
+static PyObject *__pyx_n_s__reference;
+static PyObject *__pyx_n_s__region;
+static PyObject *__pyx_n_s__regions;
+static PyObject *__pyx_n_s__replace;
+static PyObject *__pyx_n_s__samples;
+static PyObject *__pyx_n_s__self;
+static PyObject *__pyx_n_s__separator;
+static PyObject *__pyx_n_s__setfilter;
+static PyObject *__pyx_n_s__setformat;
+static PyObject *__pyx_n_s__setheader;
+static PyObject *__pyx_n_s__setinfo;
+static PyObject *__pyx_n_s__setreference;
+static PyObject *__pyx_n_s__setregions;
+static PyObject *__pyx_n_s__setsamples;
+static PyObject *__pyx_n_s__setversion;
+static PyObject *__pyx_n_s__split;
+static PyObject *__pyx_n_s__start;
+static PyObject *__pyx_n_s__startswith;
+static PyObject *__pyx_n_s__stderr;
+static PyObject *__pyx_n_s__stream;
+static PyObject *__pyx_n_s__strip;
+static PyObject *__pyx_n_s__sys;
+static PyObject *__pyx_n_s__tabixfile;
+static PyObject *__pyx_n_s__type;
+static PyObject *__pyx_n_s__upper;
+static PyObject *__pyx_n_s__validate;
+static PyObject *__pyx_n_s__value;
+static PyObject *__pyx_n_s__vcf;
+static PyObject *__pyx_n_s__vcffile;
+static PyObject *__pyx_n_s__version;
+static PyObject *__pyx_n_s__warnerror;
+static PyObject *__pyx_n_s__write;
+static PyObject *__pyx_n_s__write_data;
+static PyObject *__pyx_n_s__write_header;
+static PyObject *__pyx_n_s__write_heading;
+static PyObject *__pyx_n_s__writeheader;
+static PyObject *__pyx_n_s__zip;
+static PyObject *__pyx_int_0;
+static PyObject *__pyx_int_1;
+static PyObject *__pyx_int_2;
+static PyObject *__pyx_int_3;
+static PyObject *__pyx_int_4;
+static PyObject *__pyx_int_5;
+static PyObject *__pyx_int_6;
+static PyObject *__pyx_int_7;
+static PyObject *__pyx_int_8;
+static PyObject *__pyx_int_9;
+static PyObject *__pyx_int_neg_1;
+static PyObject *__pyx_int_10;
+static PyObject *__pyx_int_11;
+static PyObject *__pyx_int_12;
+static PyObject *__pyx_int_13;
+static PyObject *__pyx_int_14;
+static PyObject *__pyx_int_15;
+static PyObject *__pyx_int_16;
+static PyObject *__pyx_int_17;
+static PyObject *__pyx_int_18;
+static PyObject *__pyx_int_19;
+static PyObject *__pyx_int_20;
+static PyObject *__pyx_int_21;
+static PyObject *__pyx_int_22;
+static PyObject *__pyx_int_23;
+static PyObject *__pyx_int_24;
+static PyObject *__pyx_int_25;
+static PyObject *__pyx_int_26;
+static PyObject *__pyx_int_27;
+static PyObject *__pyx_int_28;
+static PyObject *__pyx_int_29;
+static PyObject *__pyx_int_30;
+static PyObject *__pyx_int_33;
+static PyObject *__pyx_int_40;
+static PyObject *__pyx_int_100;
+static PyObject *__pyx_int_3000000000;
+static PyObject *__pyx_k_13;
+static PyObject *__pyx_k_15;
+static PyObject *__pyx_k_32;
+static PyObject *__pyx_k_36;
+static PyObject *__pyx_k_37;
+static PyObject *__pyx_k_61;
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":58
+ * 
+ * # Utility function.  Uses 0-based coordinates
+ * def get_sequence(chrom, start, end, fa):             # <<<<<<<<<<<<<<
+ *     # obtain sequence from .fa file, without truncation
+ *     if end<=start: return ""
+ */
+
+static PyObject *__pyx_pf_4cvcf_get_sequence(PyObject *__pyx_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
+static PyObject *__pyx_pf_4cvcf_get_sequence(PyObject *__pyx_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
+  PyObject *__pyx_v_chrom = 0;
+  PyObject *__pyx_v_start = 0;
+  PyObject *__pyx_v_end = 0;
+  PyObject *__pyx_v_fa = 0;
+  PyObject *__pyx_v_sequence;
+  PyObject *__pyx_r = NULL;
+  PyObject *__pyx_t_1 = NULL;
+  int __pyx_t_2;
+  int __pyx_t_3;
+  PyObject *__pyx_t_4 = NULL;
+  PyObject *__pyx_t_5 = NULL;
+  PyObject *__pyx_t_6 = NULL;
+  Py_ssize_t __pyx_t_7;
+  static PyObject **__pyx_pyargnames[] = {&__pyx_n_s__chrom,&__pyx_n_s__start,&__pyx_n_s__end,&__pyx_n_s__fa,0};
+  __Pyx_RefNannySetupContext("get_sequence");
+  __pyx_self = __pyx_self;
+  if (unlikely(__pyx_kwds)) {
+    Py_ssize_t kw_args = PyDict_Size(__pyx_kwds);
+    PyObject* values[4] = {0,0,0,0};
+    switch (PyTuple_GET_SIZE(__pyx_args)) {
+      case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
+      case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
+      case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
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+    switch (PyTuple_GET_SIZE(__pyx_args)) {
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+      values[0] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__chrom);
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+      values[1] = PyDict_GetItem(__pyx_kwds, __pyx_n_s__start);
+      if (likely(values[1])) kw_args--;
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+ * def get_sequence(chrom, start, end, fa):
+ *     # obtain sequence from .fa file, without truncation
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+ *     # obtain sequence from .fa file, without truncation
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+ *     if start<0: return "N"*(-start) + get_sequence(chrom, 0, end, fa).upper()
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+    __Pyx_GOTREF(((PyObject *)__pyx_t_4));
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+ *     if not fa: return "N"*(end-start)
+ *     if start<0: return "N"*(-start) + get_sequence(chrom, 0, end, fa).upper()
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+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":355
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+ *             elif first.startswith('Number='):      data['number'] = first.split('=')[1]
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+ *                 elts = format.split('"')
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+ *             return FORMAT(data['id'],self.NT_NUMBER,0,"Flag",data['descr'],'.')
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+ *             self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
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+      __Pyx_GOTREF(__pyx_t_2);
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+ *             elif fmt.numbertype == self.NT_ALLELES: nmb = "#alleles"             # <<<<<<<<<<<<<<
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+ *             elif fmt.numbertype == self.NT_GENOTYPES: nmb = "#genotypes"
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+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":405
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+ *             elif fmt.numbertype == self.NT_NR_ALLELES: nmb = "#nonref_alleles"
+ *             elif fmt.numbertype == self.NT_GENOTYPES: nmb = "#genotypes"             # <<<<<<<<<<<<<<
+ *             elif fmt.numbertype == self.NT_PHASED_GENOTYPES: nmb = "#phased_genotypes"
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+ *             elif fmt.numbertype == self.NT_GENOTYPES: nmb = "#genotypes"
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+      __Pyx_GOTREF(__pyx_t_2);
+      PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_t_1));
+      __Pyx_GIVEREF(((PyObject *)__pyx_t_1));
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+      __pyx_t_1 = PyObject_Call(__pyx_builtin_ValueError, __pyx_t_2, NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 408; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_1);
+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+      __Pyx_Raise(__pyx_t_1, 0, 0);
+      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+    __pyx_L7:;
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+ *             values.append( ('Number',nmb) )             # <<<<<<<<<<<<<<
+ *             values.append( ('Type', fmt.type) )
+ *         values.append( ('Description', '"' + fmt.description + '"') )
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+      PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 409; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
+    }
+    __pyx_t_1 = PyTuple_New(2); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 409; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_1);
+    __Pyx_INCREF(((PyObject *)__pyx_n_s__Number));
+    PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)__pyx_n_s__Number));
+    __Pyx_GIVEREF(((PyObject *)__pyx_n_s__Number));
+    __Pyx_INCREF(__pyx_v_nmb);
+    PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_v_nmb);
+    __Pyx_GIVEREF(__pyx_v_nmb);
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+    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ *             values.append( ('Number',nmb) )
+ *             values.append( ('Type', fmt.type) )             # <<<<<<<<<<<<<<
+ *         values.append( ('Description', '"' + fmt.description + '"') )
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+    if (unlikely(__pyx_v_values == Py_None)) {
+      PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 410; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
+    }
+    __pyx_t_1 = PyObject_GetAttr(__pyx_v_fmt, __pyx_n_s__type); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 410; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+    __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 410; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_2);
+    __Pyx_INCREF(((PyObject *)__pyx_n_s__Type));
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+    __Pyx_GIVEREF(((PyObject *)__pyx_n_s__Type));
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+    __Pyx_GIVEREF(__pyx_t_1);
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+ *         values.append( ('Description', '"' + fmt.description + '"') )             # <<<<<<<<<<<<<<
+ *         if self._version == 33:
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+  __Pyx_GOTREF(__pyx_t_2);
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+  __Pyx_GOTREF(__pyx_t_2);
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __Pyx_GOTREF(__pyx_t_1);
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__Description));
+  PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)__pyx_n_s__Description));
+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__Description));
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+  __Pyx_GIVEREF(__pyx_t_2);
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+  __pyx_t_7 = PyList_Append(((PyObject *)__pyx_v_values), __pyx_t_1); if (unlikely(__pyx_t_7 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 411; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ *             values.append( ('Type', fmt.type) )
+ *         values.append( ('Description', '"' + fmt.description + '"') )
+ *         if self._version == 33:             # <<<<<<<<<<<<<<
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+  __pyx_t_1 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___version); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 412; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+ *         values.append( ('Description', '"' + fmt.description + '"') )
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+ *             format = ",".join([v for k,v in values])             # <<<<<<<<<<<<<<
+ *         else:
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+    __Pyx_GOTREF(__pyx_t_1);
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+ *             format = ",".join([v for k,v in values])
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+    __Pyx_GOTREF(((PyObject *)__pyx_t_6));
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+      __Pyx_GOTREF(__pyx_t_8);
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+ *             sdata = [('GT',map(self.convertGTback,data['GT']))] + sdata
+ *         for k,v in sdata:
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+    __Pyx_GOTREF(((PyObject *)__pyx_t_2));
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+    __Pyx_GOTREF(__pyx_t_6);
+    __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
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+ *         for k,v in sdata:
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+ *             if key and value:             # <<<<<<<<<<<<<<
+ *                 if v != None: output.append( k+"="+','.join(map(str,v)) )
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+        __Pyx_GOTREF(__pyx_t_8);
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+        __Pyx_GOTREF(__pyx_t_1);
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+        __Pyx_GOTREF(__pyx_t_8);
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+        __Pyx_GOTREF(__pyx_t_1);
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+        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+        goto __pyx_L22;
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+      /*else*/ {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":467
+ *             if key and value:
+ *                 if v != None: output.append( k+"="+','.join(map(str,v)) )
+ *                 else: output.append( k )             # <<<<<<<<<<<<<<
+ *             elif key: output.append(k)
+ *             elif value:
+ */
+        if (unlikely(__pyx_v_output == Py_None)) {
+          PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 467; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
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+        __pyx_t_9 = PyList_Append(((PyObject *)__pyx_v_output), __pyx_v_k); if (unlikely(__pyx_t_9 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 467; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+      goto __pyx_L21;
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+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":468
+ *                 if v != None: output.append( k+"="+','.join(map(str,v)) )
+ *                 else: output.append( k )
+ *             elif key: output.append(k)             # <<<<<<<<<<<<<<
+ *             elif value:
+ *                 if v != None: output.append( ','.join(map(str,v)) )
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+    if (__pyx_t_11) {
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+        PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 468; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
+      }
+      __pyx_t_9 = PyList_Append(((PyObject *)__pyx_v_output), __pyx_v_k); if (unlikely(__pyx_t_9 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 468; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      goto __pyx_L21;
+    }
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":469
+ *                 else: output.append( k )
+ *             elif key: output.append(k)
+ *             elif value:             # <<<<<<<<<<<<<<
+ *                 if v != None: output.append( ','.join(map(str,v)) )
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+    if (__pyx_t_11) {
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":470
+ *             elif key: output.append(k)
+ *             elif value:
+ *                 if v != None: output.append( ','.join(map(str,v)) )             # <<<<<<<<<<<<<<
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+        __Pyx_GIVEREF(((PyObject *)((PyObject*)&PyString_Type)));
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+        __Pyx_GOTREF(__pyx_t_6);
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+        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __pyx_t_1 = PyObject_GetAttr(__pyx_v_line, __pyx_n_s__startswith); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 490; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_GOTREF(__pyx_t_2);
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+  __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_8));
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_DECREF(__pyx_v_elts);
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+ *         key = elts[0].strip()             # <<<<<<<<<<<<<<
+ *         value = '='.join(elts[1:]).strip()
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_GOTREF(__pyx_t_1);
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+ *         if key == "fileformat":
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+    __Pyx_GOTREF(__pyx_t_3);
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+ *                 self._version = 33             # <<<<<<<<<<<<<<
+ *             elif value == "VCFv4.0":
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+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":497
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+ *                 self._version = 40
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+ *                 self._version = 33
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+ *                 self._version = 40             # <<<<<<<<<<<<<<
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+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":499
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+ *                 self._version = 40
+ *             elif value == "VCFv4.1":             # <<<<<<<<<<<<<<
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+    __Pyx_GOTREF(__pyx_t_3);
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+    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ *             elif value == "VCFv4.1":
+ *                 # AH - for testing
+ *                 self._version = 40             # <<<<<<<<<<<<<<
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+      goto __pyx_L7;
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+    /*else*/ {
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":503
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+ *             else:
+ *                 self.error(line,self.UNKNOWN_FORMAT_STRING)             # <<<<<<<<<<<<<<
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+      __Pyx_GOTREF(__pyx_t_3);
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+      __Pyx_GIVEREF(__pyx_t_2);
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+      __Pyx_GOTREF(__pyx_t_2);
+      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":504
+ *             else:
+ *                 self.error(line,self.UNKNOWN_FORMAT_STRING)
+ *         elif key == "INFO":             # <<<<<<<<<<<<<<
+ *             f = self.parse_format(line, value)
+ *             self._info[ f.id ] = f
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+  __Pyx_GOTREF(__pyx_t_2);
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+    __Pyx_GIVEREF(__pyx_v_pos);
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+  __Pyx_GOTREF(__pyx_t_12);
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+ *         ref = cols[3].upper()
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+ *             self.error(line,self.MISSING_REF)
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+ *             if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
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+ *             self.error(line,self.MISSING_REF)
+ *             if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
+ *             else:                   ref = ""             # <<<<<<<<<<<<<<
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+ *             for c in ref:             # <<<<<<<<<<<<<<
+ *                 if c not in "ACGTN": self.error(line,self.UNKNOWN_CHAR_IN_REF)
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+ *             left = max(0,pos-100)
+ *             faref_leftflank = get_sequence(chrom,left,pos+len(ref),self._reference)
+ *             faref = faref_leftflank[pos-left:]             # <<<<<<<<<<<<<<
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+ *             faref_leftflank = get_sequence(chrom,left,pos+len(ref),self._reference)
+ *             faref = faref_leftflank[pos-left:]
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+ *             ref = faref             # <<<<<<<<<<<<<<
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+    goto __pyx_L27;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":667
+ * 
+ *         # convert v3.3 to v4.0 alleles below
+ *         if cols[4] == ".": alt = []             # <<<<<<<<<<<<<<
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+ * 
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+  __Pyx_GOTREF(__pyx_t_10);
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+ *         if cols[4] == ".": alt = []
+ *         else: alt = cols[4].upper().split(',')             # <<<<<<<<<<<<<<
+ * 
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+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":708
+ *             for a in alt:
+ *                 if len(a) == 1: a = a + ref[1:]                       # SNP; add trailing reference
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+      __Pyx_GOTREF(__pyx_t_9);
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+ *                 elif a.startswith('D'): # allow D<seq> and D<num>
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
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+ */
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ *                             ref += addns             # <<<<<<<<<<<<<<
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
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+            __pyx_L66:;
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+            /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":717
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+ *                     except ValueError:
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+ */
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+            __Pyx_GOTREF(__pyx_t_12);
+            __Pyx_DECREF(__pyx_v_a);
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+          __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
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+          __Pyx_XDECREF(__pyx_t_12); __pyx_t_12 = 0;
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":718
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[l:]             # new deletion, deleting pos...pos+l
+ *                     except ValueError:             # <<<<<<<<<<<<<<
+ *                         s = a[1:]
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+          __pyx_t_16 = PyErr_ExceptionMatches(__pyx_builtin_ValueError);
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+            __Pyx_GOTREF(__pyx_t_12);
+            __Pyx_GOTREF(__pyx_t_3);
+            __Pyx_GOTREF(__pyx_t_9);
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+            /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":719
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+ *                         s = a[1:]             # <<<<<<<<<<<<<<
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+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):
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+              __Pyx_GIVEREF(__pyx_t_11);
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+              __Pyx_GOTREF(__pyx_t_11);
+              __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+ *                         if len(ref) < len(s):   # add Ns to reference if necessary
+ *                             addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):             # <<<<<<<<<<<<<<
+ *                                 self.error(line,self.V33_UNMATCHED_DELETION,
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ */
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+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):
+ *                                 self.error(line,self.V33_UNMATCHED_DELETION,             # <<<<<<<<<<<<<<
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
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+                __Pyx_GOTREF(__pyx_t_18);
+                __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+
+              /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":725
+ *                                 self.error(line,self.V33_UNMATCHED_DELETION,
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ *                             ref += addns             # <<<<<<<<<<<<<<
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
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+ */
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+              __Pyx_GOTREF(__pyx_t_18);
+              __Pyx_DECREF(__pyx_v_ref);
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+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ *                             ref += addns
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns             # <<<<<<<<<<<<<<
+ *                         a = ref[len(s):]        # new deletion, deleting from pos
+ *                 else:
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+                __Pyx_GOTREF(__pyx_t_10);
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+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[len(s):]        # new deletion, deleting from pos             # <<<<<<<<<<<<<<
+ *                 else:
+ *                     self.error(line,self.V33_BAD_ALLELE)
+ */
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+          __Pyx_ExceptionReset(__pyx_save_exc_type, __pyx_save_exc_value, __pyx_save_exc_tb);
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+          __Pyx_XGIVEREF(__pyx_save_exc_type);
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+        goto __pyx_L57;
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+ *                         a = ref[len(s):]        # new deletion, deleting from pos
+ *                 else:
+ *                     self.error(line,self.V33_BAD_ALLELE)             # <<<<<<<<<<<<<<
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+ *             alt = newalts
+ */
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+        __Pyx_GOTREF(__pyx_t_9);
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+
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+ *                 else:
+ *                     self.error(line,self.V33_BAD_ALLELE)
+ *                 newalts.append(a)             # <<<<<<<<<<<<<<
+ *             alt = newalts
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ */
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+        PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 730; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
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+
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+ *                     self.error(line,self.V33_BAD_ALLELE)
+ *                 newalts.append(a)
+ *             alt = newalts             # <<<<<<<<<<<<<<
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:
+ */
+    __Pyx_INCREF(((PyObject *)__pyx_v_newalts));
+    __Pyx_DECREF(__pyx_v_alt);
+    __pyx_v_alt = ((PyObject *)__pyx_v_newalts);
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":733
+ *             alt = newalts
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:             # <<<<<<<<<<<<<<
+ *                 if pos == 0:
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ */
+    if (__pyx_v_have_deletions) {
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":734
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:
+ *                 if pos == 0:             # <<<<<<<<<<<<<<
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ */
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+      __Pyx_GOTREF(__pyx_t_2);
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+ *                 if pos == 0:
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
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+        __Pyx_GOTREF(__pyx_t_9);
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+        __Pyx_GIVEREF(__pyx_t_9);
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+        __pyx_t_9 = 0;
+        __pyx_t_9 = PyObject_Call(__pyx_t_2, __pyx_t_18, NULL); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 736; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_9);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
+        __Pyx_DECREF(__pyx_v_addn);
+        __pyx_v_addn = __pyx_t_9;
+        __pyx_t_9 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":737
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ *                     ref += addn             # <<<<<<<<<<<<<<
+ *                     alt = [allele+addn for allele in alt]
+ *                 else:
+ */
+        __pyx_t_9 = PyNumber_InPlaceAdd(__pyx_v_ref, __pyx_v_addn); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 737; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_9);
+        __Pyx_DECREF(__pyx_v_ref);
+        __pyx_v_ref = __pyx_t_9;
+        __pyx_t_9 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":738
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ *                     ref += addn
+ *                     alt = [allele+addn for allele in alt]             # <<<<<<<<<<<<<<
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ */
+        __pyx_t_9 = PyList_New(0); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 738; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(((PyObject *)__pyx_t_9));
+        if (PyList_CheckExact(__pyx_v_alt) || PyTuple_CheckExact(__pyx_v_alt)) {
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+          __pyx_t_5 = -1; __pyx_t_18 = PyObject_GetIter(__pyx_v_alt); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 738; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_18);
+        }
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+          if (likely(PyList_CheckExact(__pyx_t_18))) {
+            if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_18)) break;
+            __pyx_t_2 = PyList_GET_ITEM(__pyx_t_18, __pyx_t_5); __Pyx_INCREF(__pyx_t_2); __pyx_t_5++;
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+            if (__pyx_t_5 >= PyTuple_GET_SIZE(__pyx_t_18)) break;
+            __pyx_t_2 = PyTuple_GET_ITEM(__pyx_t_18, __pyx_t_5); __Pyx_INCREF(__pyx_t_2); __pyx_t_5++;
+          } else {
+            __pyx_t_2 = PyIter_Next(__pyx_t_18);
+            if (!__pyx_t_2) {
+              if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 738; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+              break;
+            }
+            __Pyx_GOTREF(__pyx_t_2);
+          }
+          __Pyx_DECREF(__pyx_v_allele);
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+          __pyx_t_2 = 0;
+          __pyx_t_2 = PyNumber_Add(__pyx_v_allele, __pyx_v_addn); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 738; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_2);
+          if (unlikely(PyList_Append(__pyx_t_9, (PyObject*)__pyx_t_2))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 738; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+        __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
+        __Pyx_INCREF(((PyObject *)__pyx_t_9));
+        __Pyx_DECREF(__pyx_v_alt);
+        __pyx_v_alt = ((PyObject *)__pyx_t_9);
+        __Pyx_DECREF(((PyObject *)__pyx_t_9)); __pyx_t_9 = 0;
+        goto __pyx_L76;
+      }
+      /*else*/ {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":740
+ *                     alt = [allele+addn for allele in alt]
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)             # <<<<<<<<<<<<<<
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]
+ */
+        __pyx_t_9 = __Pyx_GetName(__pyx_m, __pyx_n_s__get_sequence); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 740; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_9);
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+        __Pyx_GOTREF(__pyx_t_18);
+        __pyx_t_2 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___reference); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 740; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __pyx_t_3 = PyTuple_New(4); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 740; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_3);
+        __Pyx_INCREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_chrom);
+        __Pyx_GIVEREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_18);
+        __Pyx_GIVEREF(__pyx_t_18);
+        __Pyx_INCREF(__pyx_v_pos);
+        PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_v_pos);
+        __Pyx_GIVEREF(__pyx_v_pos);
+        PyTuple_SET_ITEM(__pyx_t_3, 3, __pyx_t_2);
+        __Pyx_GIVEREF(__pyx_t_2);
+        __pyx_t_18 = 0;
+        __pyx_t_2 = 0;
+        __pyx_t_2 = PyObject_Call(__pyx_t_9, __pyx_t_3, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 740; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+        __Pyx_DECREF(__pyx_v_addn);
+        __pyx_v_addn = __pyx_t_2;
+        __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":741
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ *                     ref = addn + ref             # <<<<<<<<<<<<<<
+ *                     alt = [addn + allele for allele in alt]
+ *                     pos -= 1
+ */
+        __pyx_t_2 = PyNumber_Add(__pyx_v_addn, __pyx_v_ref); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_v_ref);
+        __pyx_v_ref = __pyx_t_2;
+        __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":742
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]             # <<<<<<<<<<<<<<
+ *                     pos -= 1
+ *         else:
+ */
+        __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 742; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(((PyObject *)__pyx_t_2));
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+          __Pyx_GOTREF(__pyx_t_3);
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+          if (likely(PyList_CheckExact(__pyx_t_3))) {
+            if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_3)) break;
+            __pyx_t_9 = PyList_GET_ITEM(__pyx_t_3, __pyx_t_5); __Pyx_INCREF(__pyx_t_9); __pyx_t_5++;
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+            if (__pyx_t_5 >= PyTuple_GET_SIZE(__pyx_t_3)) break;
+            __pyx_t_9 = PyTuple_GET_ITEM(__pyx_t_3, __pyx_t_5); __Pyx_INCREF(__pyx_t_9); __pyx_t_5++;
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+            __pyx_t_9 = PyIter_Next(__pyx_t_3);
+            if (!__pyx_t_9) {
+              if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 742; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+              break;
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+            __Pyx_GOTREF(__pyx_t_9);
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+          __Pyx_DECREF(__pyx_v_allele);
+          __pyx_v_allele = __pyx_t_9;
+          __pyx_t_9 = 0;
+          __pyx_t_9 = PyNumber_Add(__pyx_v_addn, __pyx_v_allele); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 742; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_9);
+          if (unlikely(PyList_Append(__pyx_t_2, (PyObject*)__pyx_t_9))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 742; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+        }
+        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+        __Pyx_INCREF(((PyObject *)__pyx_t_2));
+        __Pyx_DECREF(__pyx_v_alt);
+        __pyx_v_alt = ((PyObject *)__pyx_t_2);
+        __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":743
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]
+ *                     pos -= 1             # <<<<<<<<<<<<<<
+ *         else:
+ *             # format v4.0 -- just check for nucleotides
+ */
+        __pyx_t_2 = PyNumber_InPlaceSubtract(__pyx_v_pos, __pyx_int_1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 743; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_v_pos);
+        __pyx_v_pos = __pyx_t_2;
+        __pyx_t_2 = 0;
+      }
+      __pyx_L76:;
+      goto __pyx_L75;
+    }
+    __pyx_L75:;
+    goto __pyx_L53;
+  }
+  /*else*/ {
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":746
+ *         else:
+ *             # format v4.0 -- just check for nucleotides
+ *             for allele in alt:             # <<<<<<<<<<<<<<
+ *                 if not alleleRegEx.match(allele):
+ *                     self.error(line,self.V40_BAD_ALLELE,allele)
+ */
+    if (PyList_CheckExact(__pyx_v_alt) || PyTuple_CheckExact(__pyx_v_alt)) {
+      __pyx_t_5 = 0; __pyx_t_2 = __pyx_v_alt; __Pyx_INCREF(__pyx_t_2);
+    } else {
+      __pyx_t_5 = -1; __pyx_t_2 = PyObject_GetIter(__pyx_v_alt); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 746; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_2);
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+    for (;;) {
+      if (likely(PyList_CheckExact(__pyx_t_2))) {
+        if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_2)) break;
+        __pyx_t_3 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_5); __Pyx_INCREF(__pyx_t_3); __pyx_t_5++;
+      } else if (likely(PyTuple_CheckExact(__pyx_t_2))) {
+        if (__pyx_t_5 >= PyTuple_GET_SIZE(__pyx_t_2)) break;
+        __pyx_t_3 = PyTuple_GET_ITEM(__pyx_t_2, __pyx_t_5); __Pyx_INCREF(__pyx_t_3); __pyx_t_5++;
+      } else {
+        __pyx_t_3 = PyIter_Next(__pyx_t_2);
+        if (!__pyx_t_3) {
+          if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 746; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          break;
+        }
+        __Pyx_GOTREF(__pyx_t_3);
+      }
+      __Pyx_DECREF(__pyx_v_allele);
+      __pyx_v_allele = __pyx_t_3;
+      __pyx_t_3 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":747
+ *             # format v4.0 -- just check for nucleotides
+ *             for allele in alt:
+ *                 if not alleleRegEx.match(allele):             # <<<<<<<<<<<<<<
+ *                     self.error(line,self.V40_BAD_ALLELE,allele)
+ * 
+ */
+      __pyx_t_3 = __Pyx_GetName(__pyx_m, __pyx_n_s__alleleRegEx); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 747; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_3);
+      __pyx_t_9 = PyObject_GetAttr(__pyx_t_3, __pyx_n_s__match); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 747; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_9);
+      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+      __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 747; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_3);
+      __Pyx_INCREF(__pyx_v_allele);
+      PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_allele);
+      __Pyx_GIVEREF(__pyx_v_allele);
+      __pyx_t_18 = PyObject_Call(__pyx_t_9, __pyx_t_3, NULL); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 747; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_18);
+      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+      __pyx_t_15 = __Pyx_PyObject_IsTrue(__pyx_t_18); if (unlikely(__pyx_t_15 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 747; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
+      __pyx_t_6 = (!__pyx_t_15);
+      if (__pyx_t_6) {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":748
+ *             for allele in alt:
+ *                 if not alleleRegEx.match(allele):
+ *                     self.error(line,self.V40_BAD_ALLELE,allele)             # <<<<<<<<<<<<<<
+ * 
+ *         # check for leading nucleotide in indel calls
+ */
+        __pyx_t_18 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s__error); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 748; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_18);
+        __pyx_t_3 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s__V40_BAD_ALLELE); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 748; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_3);
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+        __Pyx_GOTREF(__pyx_t_9);
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+ *         for allele in alt:             # <<<<<<<<<<<<<<
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+ *         # check for leading nucleotide in indel calls
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+ *                 if len(allele) == 0: self.error(line,self.ZERO_LENGTH_ALLELE)
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+      __pyx_t_18 = PyObject_GetAttr(__pyx_t_9, __pyx_n_s__upper); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 754; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+      __Pyx_GOTREF(__pyx_t_3);
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+ *                 if len(allele) == 0: self.error(line,self.ZERO_LENGTH_ALLELE)
+ *                 if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
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+        __Pyx_GOTREF(__pyx_t_3);
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+ * 
+ *         # trim trailing bases in alleles
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+      if (!__pyx_t_6) break;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":766
+ *         if self._leftalign and self._reference:
+ *             while left < pos:
+ *                 movable = True             # <<<<<<<<<<<<<<
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):
+ */
+      __pyx_v_movable = 1;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":767
+ *             while left < pos:
+ *                 movable = True
+ *                 for allele in alt:             # <<<<<<<<<<<<<<
+ *                     if len(allele) > len(ref):
+ *                         longest, shortest = allele, ref
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+        __pyx_t_5 = -1; __pyx_t_18 = PyObject_GetIter(__pyx_v_alt); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 767; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_18);
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+        if (likely(PyList_CheckExact(__pyx_t_18))) {
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+          __pyx_t_2 = PyList_GET_ITEM(__pyx_t_18, __pyx_t_5); __Pyx_INCREF(__pyx_t_2); __pyx_t_5++;
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+          if (__pyx_t_5 >= PyTuple_GET_SIZE(__pyx_t_18)) break;
+          __pyx_t_2 = PyTuple_GET_ITEM(__pyx_t_18, __pyx_t_5); __Pyx_INCREF(__pyx_t_2); __pyx_t_5++;
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+          __pyx_t_2 = PyIter_Next(__pyx_t_18);
+          if (!__pyx_t_2) {
+            if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 767; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+            break;
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+          __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_DECREF(__pyx_v_allele);
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+        __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":768
+ *                 movable = True
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):             # <<<<<<<<<<<<<<
+ *                         longest, shortest = allele, ref
+ *                     else:
+ */
+        __pyx_t_4 = PyObject_Length(__pyx_v_allele); if (unlikely(__pyx_t_4 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 768; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+        __pyx_t_6 = (__pyx_t_4 > __pyx_t_17);
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+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":769
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):
+ *                         longest, shortest = allele, ref             # <<<<<<<<<<<<<<
+ *                     else:
+ *                         longest, shortest = ref, allele
+ */
+          __pyx_t_2 = __pyx_v_allele;
+          __Pyx_INCREF(__pyx_t_2);
+          __pyx_t_9 = __pyx_v_ref;
+          __Pyx_INCREF(__pyx_t_9);
+          __Pyx_DECREF(__pyx_v_longest);
+          __pyx_v_longest = __pyx_t_2;
+          __pyx_t_2 = 0;
+          __Pyx_DECREF(__pyx_v_shortest);
+          __pyx_v_shortest = __pyx_t_9;
+          __pyx_t_9 = 0;
+          goto __pyx_L101;
+        }
+        /*else*/ {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":771
+ *                         longest, shortest = allele, ref
+ *                     else:
+ *                         longest, shortest = ref, allele             # <<<<<<<<<<<<<<
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False
+ */
+          __pyx_t_9 = __pyx_v_ref;
+          __Pyx_INCREF(__pyx_t_9);
+          __pyx_t_2 = __pyx_v_allele;
+          __Pyx_INCREF(__pyx_t_2);
+          __Pyx_DECREF(__pyx_v_longest);
+          __pyx_v_longest = __pyx_t_9;
+          __pyx_t_9 = 0;
+          __Pyx_DECREF(__pyx_v_shortest);
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+          __pyx_t_2 = 0;
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+        __pyx_L101:;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":772
+ *                     else:
+ *                         longest, shortest = ref, allele
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():             # <<<<<<<<<<<<<<
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
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+        __pyx_t_17 = PyObject_Length(__pyx_v_longest); if (unlikely(__pyx_t_17 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_4 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_4 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_6 = (__pyx_t_17 == __pyx_t_4);
+        if (!__pyx_t_6) {
+          __pyx_t_4 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_4 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __pyx_t_2 = PySequence_GetSlice(__pyx_v_longest, 0, __pyx_t_4); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_2);
+          __pyx_t_9 = PyObject_GetAttr(__pyx_t_2, __pyx_n_s__upper); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_9);
+          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+          __pyx_t_2 = PyObject_Call(__pyx_t_9, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_2);
+          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+          __pyx_t_9 = PyObject_GetAttr(__pyx_v_shortest, __pyx_n_s__upper); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_9);
+          __pyx_t_3 = PyObject_Call(__pyx_t_9, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_3);
+          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+          __pyx_t_9 = PyObject_RichCompare(__pyx_t_2, __pyx_t_3, Py_NE); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_9);
+          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+          __pyx_t_15 = __Pyx_PyObject_IsTrue(__pyx_t_9); if (unlikely(__pyx_t_15 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 772; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
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+        }
+        if (__pyx_t_8) {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":773
+ *                         longest, shortest = ref, allele
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False             # <<<<<<<<<<<<<<
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False
+ */
+          __pyx_v_movable = 0;
+          goto __pyx_L102;
+        }
+        __pyx_L102:;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":774
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():             # <<<<<<<<<<<<<<
+ *                         movable = False
+ *                 if not movable:
+ */
+        __pyx_t_9 = __Pyx_GetItemInt(__pyx_v_longest, -1, sizeof(long), PyInt_FromLong); if (!__pyx_t_9) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_9);
+        __pyx_t_3 = PyObject_GetAttr(__pyx_t_9, __pyx_n_s__upper); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_3);
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+        __Pyx_GOTREF(__pyx_t_9);
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+        __pyx_t_4 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_4 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_17 = (__pyx_t_4 - 1);
+        __pyx_t_3 = __Pyx_GetItemInt(__pyx_v_longest, __pyx_t_17, sizeof(Py_ssize_t), PyInt_FromSsize_t); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_3);
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+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+        __pyx_t_3 = PyObject_Call(__pyx_t_2, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_3);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        __pyx_t_2 = PyObject_RichCompare(__pyx_t_9, __pyx_t_3, Py_NE); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
+        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+        __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_8 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 774; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":775
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False             # <<<<<<<<<<<<<<
+ *                 if not movable:
+ *                     break
+ */
+          __pyx_v_movable = 0;
+          goto __pyx_L103;
+        }
+        __pyx_L103:;
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+      __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":776
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False
+ *                 if not movable:             # <<<<<<<<<<<<<<
+ *                     break
+ *                 ref = ref[:-1]
+ */
+      __pyx_t_8 = (!__pyx_v_movable);
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+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":777
+ *                         movable = False
+ *                 if not movable:
+ *                     break             # <<<<<<<<<<<<<<
+ *                 ref = ref[:-1]
+ *                 alt = [allele[:-1] for allele in alt]
+ */
+        goto __pyx_L98_break;
+        goto __pyx_L104;
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+      __pyx_L104:;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":778
+ *                 if not movable:
+ *                     break
+ *                 ref = ref[:-1]             # <<<<<<<<<<<<<<
+ *                 alt = [allele[:-1] for allele in alt]
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+ */
+      __pyx_t_18 = PySequence_GetSlice(__pyx_v_ref, 0, -1); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 778; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_18);
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+      __pyx_v_ref = __pyx_t_18;
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+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":779
+ *                     break
+ *                 ref = ref[:-1]
+ *                 alt = [allele[:-1] for allele in alt]             # <<<<<<<<<<<<<<
+ *                 if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
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+        __Pyx_GOTREF(__pyx_t_2);
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+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+      __Pyx_DECREF(((PyObject *)__pyx_t_18)); __pyx_t_18 = 0;
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+ *                     ref = faref_leftflank[pos-left-1] + ref
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+      __pyx_t_18 = PyList_New(0); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 780; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+          __pyx_t_3 = PyIter_Next(__pyx_t_2);
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+          __Pyx_GOTREF(__pyx_t_3);
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+      __Pyx_INCREF(((PyObject *)__pyx_t_18));
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+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_GOTREF(__pyx_t_18);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
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+        __Pyx_GOTREF(__pyx_t_18);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        __Pyx_DECREF(__pyx_v_ref);
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+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":782
+ *                 if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
+ *                     ref = faref_leftflank[pos-left-1] + ref
+ *                     alt = [faref_leftflank[pos-left-1] + allele for allele in alt]             # <<<<<<<<<<<<<<
+ *                     pos -= 1
+ * 
+ */
+        __pyx_t_18 = PyList_New(0); if (unlikely(!__pyx_t_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 782; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(((PyObject *)__pyx_t_18));
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+            __pyx_t_3 = PyIter_Next(__pyx_t_2);
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+              if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 782; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+              break;
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+            __Pyx_GOTREF(__pyx_t_3);
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+          __Pyx_GOTREF(__pyx_t_3);
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+          __Pyx_GOTREF(__pyx_t_9);
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+          __Pyx_GOTREF(__pyx_t_3);
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+          __Pyx_GOTREF(__pyx_t_9);
+          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
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+        __Pyx_INCREF(((PyObject *)__pyx_t_18));
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+        __Pyx_DECREF(((PyObject *)__pyx_t_18)); __pyx_t_18 = 0;
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+ *                     ref = faref_leftflank[pos-left-1] + ref
+ *                     alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
+ *                     pos -= 1             # <<<<<<<<<<<<<<
+ * 
+ *         # parse sample columns
+ */
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+        __Pyx_GOTREF(__pyx_t_18);
+        __Pyx_DECREF(__pyx_v_pos);
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+        __pyx_t_18 = 0;
+        goto __pyx_L107;
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+      __pyx_L107:;
+    }
+    __pyx_L98_break:;
+    goto __pyx_L96;
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+  __pyx_L96:;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":786
+ * 
+ *         # parse sample columns
+ *         samples = []             # <<<<<<<<<<<<<<
+ *         for sample in cols[9:]:
+ *             dict = {}
+ */
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_18));
+  __Pyx_DECREF(((PyObject *)__pyx_v_samples));
+  __pyx_v_samples = __pyx_t_18;
+  __pyx_t_18 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":787
+ *         # parse sample columns
+ *         samples = []
+ *         for sample in cols[9:]:             # <<<<<<<<<<<<<<
+ *             dict = {}
+ *             values = sample.split(':')
+ */
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+  __Pyx_GOTREF(__pyx_t_18);
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+    __Pyx_GOTREF(__pyx_t_2);
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+      if (!__pyx_t_18) {
+        if (unlikely(PyErr_Occurred())) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 787; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        break;
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+      __Pyx_GOTREF(__pyx_t_18);
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+    __pyx_t_18 = 0;
+
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+ *         samples = []
+ *         for sample in cols[9:]:
+ *             dict = {}             # <<<<<<<<<<<<<<
+ *             values = sample.split(':')
+ *             if len(values) > len(format):
+ */
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+    __Pyx_GOTREF(((PyObject *)__pyx_t_18));
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+    __pyx_t_18 = 0;
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+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":789
+ *         for sample in cols[9:]:
+ *             dict = {}
+ *             values = sample.split(':')             # <<<<<<<<<<<<<<
+ *             if len(values) > len(format):
+ *                 self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))
+ */
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+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":790
+ *             dict = {}
+ *             values = sample.split(':')
+ *             if len(values) > len(format):             # <<<<<<<<<<<<<<
+ *                 self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))
+ *             for idx in range(len(format)):
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+ *             if len(values) > len(format):
+ *                 self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))             # <<<<<<<<<<<<<<
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+ *                 expected = self.get_expected(format[idx], self._format, alt)
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+ *                 expected = self.get_expected(format[idx], self._format, alt)
+ *                 if idx < len(values): value = values[idx]             # <<<<<<<<<<<<<<
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+ *                 if idx < len(values): value = values[idx]
+ *                 else:
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+ *                     else: value = ",".join(["."]*expected)
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+ *                     else: value = ",".join(["."]*expected)             # <<<<<<<<<<<<<<
+ *                 dict[format[idx]] = self.parse_formatdata(format[idx], value, self._format, line)
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__ref));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__alt));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__info));
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+  __Pyx_GOTREF(__pyx_t_3);
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+ *             if k not in data: raise ValueError("Required key %s not found in data" % str(k))
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+      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
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+  __Pyx_GOTREF(__pyx_t_1);
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+ *         if data['filter'] == None: filter = "."             # <<<<<<<<<<<<<<
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+  __pyx_t_2 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__filter)); if (!__pyx_t_2) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 828; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_2);
+  __pyx_t_3 = PyObject_RichCompare(__pyx_t_2, Py_None, Py_EQ); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 828; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+  __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_5 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 828; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+    __Pyx_DECREF(__pyx_v_filter);
+    __pyx_v_filter = ((PyObject *)__pyx_kp_s_6);
+    goto __pyx_L10;
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+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":829
+ *         else: alt = ",".join(data['alt'])
+ *         if data['filter'] == None: filter = "."
+ *         elif data['filter'] == []:             # <<<<<<<<<<<<<<
+ *             if self._version == 33: filter = "0"
+ *             else: filter = "PASS"
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+  __pyx_t_3 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__filter)); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 829; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 829; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_2));
+  __pyx_t_1 = PyObject_RichCompare(__pyx_t_3, ((PyObject *)__pyx_t_2), Py_EQ); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 829; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
+  __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely(__pyx_t_5 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 829; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":830
+ *         if data['filter'] == None: filter = "."
+ *         elif data['filter'] == []:
+ *             if self._version == 33: filter = "0"             # <<<<<<<<<<<<<<
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+ *         else: filter = ';'.join(data['filter'])
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+    __pyx_t_1 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___version); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 830; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_1);
+    __pyx_t_2 = PyObject_RichCompare(__pyx_t_1, __pyx_int_33, Py_EQ); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 830; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_2);
+    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+    __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_5 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 830; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+    if (__pyx_t_5) {
+      __Pyx_INCREF(((PyObject *)__pyx_kp_s__0));
+      __Pyx_DECREF(__pyx_v_filter);
+      __pyx_v_filter = ((PyObject *)__pyx_kp_s__0);
+      goto __pyx_L11;
+    }
+    /*else*/ {
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":831
+ *         elif data['filter'] == []:
+ *             if self._version == 33: filter = "0"
+ *             else: filter = "PASS"             # <<<<<<<<<<<<<<
+ *         else: filter = ';'.join(data['filter'])
+ *         if data['qual'] == -1: qual = "."
+ */
+      __Pyx_INCREF(((PyObject *)__pyx_n_s__PASS));
+      __Pyx_DECREF(__pyx_v_filter);
+      __pyx_v_filter = ((PyObject *)__pyx_n_s__PASS);
+    }
+    __pyx_L11:;
+    goto __pyx_L10;
+  }
+  /*else*/ {
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":832
+ *             if self._version == 33: filter = "0"
+ *             else: filter = "PASS"
+ *         else: filter = ';'.join(data['filter'])             # <<<<<<<<<<<<<<
+ *         if data['qual'] == -1: qual = "."
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+    __pyx_t_2 = PyObject_GetAttr(((PyObject *)__pyx_kp_s_7), __pyx_n_s__join); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 832; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_2);
+    __pyx_t_1 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__filter)); if (!__pyx_t_1) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 832; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_1);
+    __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 832; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_3);
+    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
+    __Pyx_GIVEREF(__pyx_t_1);
+    __pyx_t_1 = 0;
+    __pyx_t_1 = PyObject_Call(__pyx_t_2, __pyx_t_3, NULL); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 832; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_1);
+    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+    __Pyx_DECREF(__pyx_v_filter);
+    __pyx_v_filter = __pyx_t_1;
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+  __pyx_L10:;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":833
+ *             else: filter = "PASS"
+ *         else: filter = ';'.join(data['filter'])
+ *         if data['qual'] == -1: qual = "."             # <<<<<<<<<<<<<<
+ *         else: qual = str(data['qual'])
+ * 
+ */
+  __pyx_t_1 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__qual)); if (!__pyx_t_1) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 833; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
+  __pyx_t_3 = PyObject_RichCompare(__pyx_t_1, __pyx_int_neg_1, Py_EQ); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 833; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (__pyx_t_5) {
+    __Pyx_INCREF(((PyObject *)__pyx_kp_s_6));
+    __Pyx_DECREF(__pyx_v_qual);
+    __pyx_v_qual = ((PyObject *)__pyx_kp_s_6);
+    goto __pyx_L12;
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+  /*else*/ {
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":834
+ *         else: filter = ';'.join(data['filter'])
+ *         if data['qual'] == -1: qual = "."
+ *         else: qual = str(data['qual'])             # <<<<<<<<<<<<<<
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+ *         output = [data['chrom'],
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+    __pyx_t_3 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__qual)); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 834; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_3);
+    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 834; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_1);
+    PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_t_3);
+    __Pyx_GIVEREF(__pyx_t_3);
+    __pyx_t_3 = 0;
+    __pyx_t_3 = PyObject_Call(((PyObject *)((PyObject*)&PyString_Type)), __pyx_t_1, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 834; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __Pyx_GOTREF(__pyx_t_3);
+    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+    __Pyx_DECREF(__pyx_v_qual);
+    __pyx_v_qual = __pyx_t_3;
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+  __pyx_L12:;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":836
+ *         else: qual = str(data['qual'])
+ * 
+ *         output = [data['chrom'],             # <<<<<<<<<<<<<<
+ *                   str(data['pos']+1),   # change to 1-based position
+ *                   data['id'],
+ */
+  __pyx_t_3 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__chrom)); if (!__pyx_t_3) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 836; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":837
+ * 
+ *         output = [data['chrom'],
+ *                   str(data['pos']+1),   # change to 1-based position             # <<<<<<<<<<<<<<
+ *                   data['id'],
+ *                   data['ref'],
+ */
+  __pyx_t_1 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__pos)); if (!__pyx_t_1) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 837; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
+  __pyx_t_2 = PyNumber_Add(__pyx_t_1, __pyx_int_1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 837; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_2);
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 837; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
+  PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_t_2);
+  __Pyx_GIVEREF(__pyx_t_2);
+  __pyx_t_2 = 0;
+  __pyx_t_2 = PyObject_Call(((PyObject *)((PyObject*)&PyString_Type)), __pyx_t_1, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 837; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_2);
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":838
+ *         output = [data['chrom'],
+ *                   str(data['pos']+1),   # change to 1-based position
+ *                   data['id'],             # <<<<<<<<<<<<<<
+ *                   data['ref'],
+ *                   alt,
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+  __pyx_t_1 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__id)); if (!__pyx_t_1) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 838; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":839
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+ *                   data['id'],
+ *                   data['ref'],             # <<<<<<<<<<<<<<
+ *                   alt,
+ *                   qual,
+ */
+  __pyx_t_6 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__ref)); if (!__pyx_t_6) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 839; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_6);
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":843
+ *                   qual,
+ *                   filter,
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+ *                   self.format_formatdata( data['format'], self._format, value=False ) ]
+ * 
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+  __Pyx_GOTREF(__pyx_t_7);
+  __pyx_t_8 = PyObject_GetItem(__pyx_v_data, ((PyObject *)__pyx_n_s__info)); if (!__pyx_t_8) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 843; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_8);
+  __pyx_t_9 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___info); if (unlikely(!__pyx_t_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 843; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_9);
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+  __Pyx_GOTREF(__pyx_t_10);
+  PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_t_8);
+  __Pyx_GIVEREF(__pyx_t_8);
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+  __Pyx_GIVEREF(__pyx_t_9);
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_9));
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+  __pyx_t_8 = PyEval_CallObjectWithKeywords(__pyx_t_7, __pyx_t_10, ((PyObject *)__pyx_t_9)); if (unlikely(!__pyx_t_8)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 843; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_8);
+  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
+  __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+  __Pyx_DECREF(((PyObject *)__pyx_t_9)); __pyx_t_9 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":844
+ *                   filter,
+ *                   self.format_formatdata( data['info'], self._info, separator=";" ),
+ *                   self.format_formatdata( data['format'], self._format, value=False ) ]             # <<<<<<<<<<<<<<
+ * 
+ *         for s in self._samples:
+ */
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+  __Pyx_GOTREF(__pyx_t_9);
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+  __Pyx_GOTREF(__pyx_t_10);
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+ *         ref = record.ref
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+ *             else:                   ref = ""             # <<<<<<<<<<<<<<
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+ *             for c in ref:
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+ *             for c in ref:
+ *                 if c not in "ACGTN": self.error(str(record),self.UNKNOWN_CHAR_IN_REF)
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+ *                                                   pos+len(ref),
+ */
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+        __Pyx_GOTREF(__pyx_t_5);
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1014
+ *                 if "N" in ref: ref = get_sequence(chrom,
+ *                                                   pos,
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+ *                                                   self._reference)
+ * 
+ */
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+        __Pyx_GOTREF(__pyx_t_4);
+        __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
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+ * 
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+ *             faref = faref_leftflank[pos-left:]
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+ *         # check: format fields are defined
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+ *         for f in record.format:             # <<<<<<<<<<<<<<
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+ *         # check: all filters are defined
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+ *             if len(ref) != 1: self.error(str(record),self.V33_BAD_REF)
+ *             newalts = []
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+        goto __pyx_L24;
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+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1040
+ *             for a in alt:
+ *                 if len(a) == 1: a = a + ref[1:]                       # SNP; add trailing reference
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+ *                 elif a.startswith('D'): # allow D<seq> and D<num>
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+      __Pyx_GOTREF(__pyx_t_2);
+      __Pyx_INCREF(((PyObject *)__pyx_n_s__I));
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+        __Pyx_GOTREF(__pyx_t_7);
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+ *                     have_deletions = True
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+ */
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+      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ *                 elif a.startswith('D'): # allow D<seq> and D<num>
+ *                     have_deletions = True             # <<<<<<<<<<<<<<
+ *                     try:
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+ *                         if len(ref) < l:        # add to reference if necessary
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ *                             ref += addns
+ */
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+            __Pyx_GOTREF(__pyx_t_2);
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+ *                         if len(ref) < l:        # add to reference if necessary
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+ *                             ref += addns
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+              __Pyx_GOTREF(__pyx_t_7);
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+              __Pyx_GOTREF(__pyx_t_1);
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+ *                         if len(ref) < l:        # add to reference if necessary
+ *                             addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ *                             ref += addns             # <<<<<<<<<<<<<<
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ *                             ref += addns
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns             # <<<<<<<<<<<<<<
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+                __Pyx_GOTREF(__pyx_t_2);
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+                __Pyx_GOTREF(__pyx_t_2);
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+              goto __pyx_L33;
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+            __pyx_L33:;
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+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[l:]             # new deletion, deleting pos...pos+l             # <<<<<<<<<<<<<<
+ *                     except ValueError:
+ *                         s = a[1:]
+ */
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+            __Pyx_GOTREF(__pyx_t_4);
+            __Pyx_DECREF(__pyx_v_a);
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+          __Pyx_XDECREF(__pyx_save_exc_tb); __pyx_save_exc_tb = 0;
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+          __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
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+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1050
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[l:]             # new deletion, deleting pos...pos+l
+ *                     except ValueError:             # <<<<<<<<<<<<<<
+ *                         s = a[1:]
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+            __Pyx_GOTREF(__pyx_t_4);
+            __Pyx_GOTREF(__pyx_t_10);
+            __Pyx_GOTREF(__pyx_t_2);
+
+            /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1051
+ *                         a = ref[l:]             # new deletion, deleting pos...pos+l
+ *                     except ValueError:
+ *                         s = a[1:]             # <<<<<<<<<<<<<<
+ *                         if len(ref) < len(s):   # add Ns to reference if necessary
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+ */
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+ *                         s = a[1:]
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
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+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):
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+              __Pyx_GOTREF(__pyx_t_15);
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+              __Pyx_GIVEREF(__pyx_t_13);
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+              __Pyx_GIVEREF(__pyx_t_14);
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+              __Pyx_GIVEREF(__pyx_t_7);
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+              __pyx_t_7 = PyObject_Call(__pyx_t_1, __pyx_t_15, NULL); if (unlikely(!__pyx_t_7)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1053; __pyx_clineno = __LINE__; goto __pyx_L27_except_error;}
+              __Pyx_GOTREF(__pyx_t_7);
+              __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+              __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
+              __Pyx_DECREF(__pyx_v_addns);
+              __pyx_v_addns = __pyx_t_7;
+              __pyx_t_7 = 0;
+
+              /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1054
+ *                         if len(ref) < len(s):   # add Ns to reference if necessary
+ *                             addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):             # <<<<<<<<<<<<<<
+ *                                 self.error(str(record),self.V33_UNMATCHED_DELETION,
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ */
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+              __Pyx_GOTREF(__pyx_t_7);
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+              __Pyx_GOTREF(__pyx_t_15);
+              __Pyx_INCREF(__pyx_v_addns);
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+              __Pyx_GIVEREF(__pyx_v_addns);
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+                __Pyx_GOTREF(((PyObject *)__pyx_t_15));
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+                __Pyx_GOTREF(__pyx_t_1);
+                __Pyx_DECREF(((PyObject *)__pyx_t_15)); __pyx_t_15 = 0;
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+                __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ *                             addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):
+ *                                 self.error(str(record),self.V33_UNMATCHED_DELETION,             # <<<<<<<<<<<<<<
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ *                             ref += addns
+ */
+                __pyx_t_1 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s__error); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1055; __pyx_clineno = __LINE__; goto __pyx_L27_except_error;}
+                __Pyx_GOTREF(__pyx_t_1);
+                __pyx_t_15 = PyTuple_New(1); if (unlikely(!__pyx_t_15)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1055; __pyx_clineno = __LINE__; goto __pyx_L27_except_error;}
+                __Pyx_GOTREF(__pyx_t_15);
+                __Pyx_INCREF(__pyx_v_record);
+                PyTuple_SET_ITEM(__pyx_t_15, 0, __pyx_v_record);
+                __Pyx_GIVEREF(__pyx_v_record);
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+                __Pyx_GOTREF(__pyx_t_7);
+                __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
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+                __Pyx_GOTREF(__pyx_t_15);
+
+                /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1056
+ *                             if not s.endswith(addns) and addns != 'N'*len(addns):
+ *                                 self.error(str(record),self.V33_UNMATCHED_DELETION,
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))             # <<<<<<<<<<<<<<
+ *                             ref += addns
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
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+                __Pyx_GOTREF(__pyx_t_14);
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+                __Pyx_GOTREF(__pyx_t_13);
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+                __Pyx_GOTREF(__pyx_t_13);
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+                __Pyx_INCREF(__pyx_v_a);
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+                PyTuple_SET_ITEM(__pyx_t_19, 1, __pyx_t_13);
+                __Pyx_GIVEREF(__pyx_t_13);
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+                __Pyx_GIVEREF(__pyx_t_15);
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+                __Pyx_GIVEREF(((PyObject *)__pyx_t_13));
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+                __Pyx_GOTREF(__pyx_t_13);
+                __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+                __Pyx_DECREF(__pyx_t_19); __pyx_t_19 = 0;
+                __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+                goto __pyx_L39;
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+              __pyx_L39:;
+
+              /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1057
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+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ *                             ref += addns             # <<<<<<<<<<<<<<
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[len(s):]        # new deletion, deleting from pos
+ */
+              __pyx_t_13 = PyNumber_InPlaceAdd(__pyx_v_ref, __pyx_v_addns); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1057; __pyx_clineno = __LINE__; goto __pyx_L27_except_error;}
+              __Pyx_GOTREF(__pyx_t_13);
+              __Pyx_DECREF(__pyx_v_ref);
+              __pyx_v_ref = __pyx_t_13;
+              __pyx_t_13 = 0;
+
+              /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1058
+ *                                            "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ *                             ref += addns
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns             # <<<<<<<<<<<<<<
+ *                         a = ref[len(s):]        # new deletion, deleting from pos
+ *                 else:
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+                __Pyx_GOTREF(__pyx_t_1);
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+                __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+              goto __pyx_L38;
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+            __pyx_L38:;
+
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+ *                             ref += addns
+ *                             for i,na in enumerate(newalts): newalts[i] = na+addns
+ *                         a = ref[len(s):]        # new deletion, deleting from pos             # <<<<<<<<<<<<<<
+ *                 else:
+ *                     self.error(str(record),self.V33_BAD_ALLELE)
+ */
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+            __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+            goto __pyx_L26_exception_handled;
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+          __pyx_L27_except_error:;
+          __Pyx_XGIVEREF(__pyx_save_exc_type);
+          __Pyx_XGIVEREF(__pyx_save_exc_value);
+          __Pyx_XGIVEREF(__pyx_save_exc_tb);
+          __Pyx_ExceptionReset(__pyx_save_exc_type, __pyx_save_exc_value, __pyx_save_exc_tb);
+          goto __pyx_L1_error;
+          __pyx_L26_exception_handled:;
+          __Pyx_XGIVEREF(__pyx_save_exc_type);
+          __Pyx_XGIVEREF(__pyx_save_exc_value);
+          __Pyx_XGIVEREF(__pyx_save_exc_tb);
+          __Pyx_ExceptionReset(__pyx_save_exc_type, __pyx_save_exc_value, __pyx_save_exc_tb);
+          __pyx_L32_try_end:;
+        }
+        goto __pyx_L24;
+      }
+      /*else*/ {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1061
+ *                         a = ref[len(s):]        # new deletion, deleting from pos
+ *                 else:
+ *                     self.error(str(record),self.V33_BAD_ALLELE)             # <<<<<<<<<<<<<<
+ *                 newalts.append(a)
+ *             alt = newalts
+ */
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+        __Pyx_GOTREF(__pyx_t_10);
+        __Pyx_INCREF(__pyx_v_record);
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+        __Pyx_GOTREF(__pyx_t_4);
+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+        __Pyx_GOTREF(__pyx_t_13);
+        PyTuple_SET_ITEM(__pyx_t_13, 0, __pyx_t_4);
+        __Pyx_GIVEREF(__pyx_t_4);
+        PyTuple_SET_ITEM(__pyx_t_13, 1, __pyx_t_10);
+        __Pyx_GIVEREF(__pyx_t_10);
+        __pyx_t_4 = 0;
+        __pyx_t_10 = 0;
+        __pyx_t_10 = PyObject_Call(__pyx_t_2, __pyx_t_13, NULL); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1061; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_10);
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+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+      __pyx_L24:;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1062
+ *                 else:
+ *                     self.error(str(record),self.V33_BAD_ALLELE)
+ *                 newalts.append(a)             # <<<<<<<<<<<<<<
+ *             alt = newalts
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ */
+      if (unlikely(__pyx_v_newalts == Py_None)) {
+        PyErr_SetString(PyExc_AttributeError, "'NoneType' object has no attribute 'append'"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1062; __pyx_clineno = __LINE__; goto __pyx_L1_error;} 
+      }
+      __pyx_t_11 = PyList_Append(((PyObject *)__pyx_v_newalts), __pyx_v_a); if (unlikely(__pyx_t_11 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1062; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    }
+    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1063
+ *                     self.error(str(record),self.V33_BAD_ALLELE)
+ *                 newalts.append(a)
+ *             alt = newalts             # <<<<<<<<<<<<<<
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:
+ */
+    __Pyx_INCREF(((PyObject *)__pyx_v_newalts));
+    __Pyx_DECREF(((PyObject *)__pyx_v_alt));
+    __pyx_v_alt = __pyx_v_newalts;
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1065
+ *             alt = newalts
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:             # <<<<<<<<<<<<<<
+ *                 if pos == 0:
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ */
+    if (__pyx_v_have_deletions) {
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1066
+ *             # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ *             if have_deletions:
+ *                 if pos == 0:             # <<<<<<<<<<<<<<
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ */
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+      __Pyx_GOTREF(__pyx_t_5);
+      __pyx_t_17 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_17 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1066; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+      if (__pyx_t_17) {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1068
+ *                 if pos == 0:
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)             # <<<<<<<<<<<<<<
+ *                     ref += addn
+ *                     alt = [allele+addn for allele in alt]
+ */
+        __pyx_t_5 = __Pyx_GetName(__pyx_m, __pyx_n_s__get_sequence); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
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+        __Pyx_GOTREF(__pyx_t_10);
+        __pyx_t_13 = PyNumber_Add(__pyx_v_pos, __pyx_t_10); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_13);
+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+        __pyx_t_10 = PyInt_FromSsize_t(__pyx_t_6); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_10);
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+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+        __pyx_t_10 = PyNumber_Add(__pyx_t_2, __pyx_int_1); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_10);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        __pyx_t_2 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___reference); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __pyx_t_4 = PyTuple_New(4); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        __Pyx_INCREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_v_chrom);
+        __Pyx_GIVEREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_13);
+        __Pyx_GIVEREF(__pyx_t_13);
+        PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_t_10);
+        __Pyx_GIVEREF(__pyx_t_10);
+        PyTuple_SET_ITEM(__pyx_t_4, 3, __pyx_t_2);
+        __Pyx_GIVEREF(__pyx_t_2);
+        __pyx_t_13 = 0;
+        __pyx_t_10 = 0;
+        __pyx_t_2 = 0;
+        __pyx_t_2 = PyObject_Call(__pyx_t_5, __pyx_t_4, NULL); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1068; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+        __Pyx_DECREF(__pyx_v_addn);
+        __pyx_v_addn = __pyx_t_2;
+        __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1069
+ *                     # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ *                     ref += addn             # <<<<<<<<<<<<<<
+ *                     alt = [allele+addn for allele in alt]
+ *                 else:
+ */
+        __pyx_t_2 = PyNumber_InPlaceAdd(__pyx_v_ref, __pyx_v_addn); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1069; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_DECREF(__pyx_v_ref);
+        __pyx_v_ref = __pyx_t_2;
+        __pyx_t_2 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1070
+ *                     addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ *                     ref += addn
+ *                     alt = [allele+addn for allele in alt]             # <<<<<<<<<<<<<<
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ */
+        __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1070; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(((PyObject *)__pyx_t_2));
+        if (likely(((PyObject *)__pyx_v_alt) != Py_None)) {
+          __pyx_t_6 = 0; __pyx_t_4 = ((PyObject *)__pyx_v_alt); __Pyx_INCREF(__pyx_t_4);
+        } else {
+          PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1070; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        }
+        for (;;) {
+          if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_4)) break;
+          __pyx_t_5 = PyList_GET_ITEM(__pyx_t_4, __pyx_t_6); __Pyx_INCREF(__pyx_t_5); __pyx_t_6++;
+          __Pyx_DECREF(__pyx_v_allele);
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+          __Pyx_GOTREF(__pyx_t_5);
+          if (unlikely(PyList_Append(__pyx_t_2, (PyObject*)__pyx_t_5))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1070; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+        __Pyx_INCREF(((PyObject *)__pyx_t_2));
+        __Pyx_DECREF(((PyObject *)__pyx_v_alt));
+        __pyx_v_alt = __pyx_t_2;
+        __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
+        goto __pyx_L43;
+      }
+      /*else*/ {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1072
+ *                     alt = [allele+addn for allele in alt]
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)             # <<<<<<<<<<<<<<
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]
+ */
+        __pyx_t_2 = __Pyx_GetName(__pyx_m, __pyx_n_s__get_sequence); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1072; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_GOTREF(__pyx_t_4);
+        __pyx_t_5 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s___reference); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1072; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __pyx_t_10 = PyTuple_New(4); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1072; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_10);
+        __Pyx_INCREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_v_chrom);
+        __Pyx_GIVEREF(__pyx_v_chrom);
+        PyTuple_SET_ITEM(__pyx_t_10, 1, __pyx_t_4);
+        __Pyx_GIVEREF(__pyx_t_4);
+        __Pyx_INCREF(__pyx_v_pos);
+        PyTuple_SET_ITEM(__pyx_t_10, 2, __pyx_v_pos);
+        __Pyx_GIVEREF(__pyx_v_pos);
+        PyTuple_SET_ITEM(__pyx_t_10, 3, __pyx_t_5);
+        __Pyx_GIVEREF(__pyx_t_5);
+        __pyx_t_4 = 0;
+        __pyx_t_5 = 0;
+        __pyx_t_5 = PyObject_Call(__pyx_t_2, __pyx_t_10, NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1072; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+        __Pyx_DECREF(__pyx_v_addn);
+        __pyx_v_addn = __pyx_t_5;
+        __pyx_t_5 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1073
+ *                 else:
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ *                     ref = addn + ref             # <<<<<<<<<<<<<<
+ *                     alt = [addn + allele for allele in alt]
+ *                     pos -= 1
+ */
+        __pyx_t_5 = PyNumber_Add(__pyx_v_addn, __pyx_v_ref); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1073; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __Pyx_DECREF(__pyx_v_ref);
+        __pyx_v_ref = __pyx_t_5;
+        __pyx_t_5 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1074
+ *                     addn = get_sequence(chrom,pos-1,pos,self._reference)
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]             # <<<<<<<<<<<<<<
+ *                     pos -= 1
+ *         else:
+ */
+        __pyx_t_5 = PyList_New(0); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1074; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(((PyObject *)__pyx_t_5));
+        if (likely(((PyObject *)__pyx_v_alt) != Py_None)) {
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+          PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1074; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        }
+        for (;;) {
+          if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_10)) break;
+          __pyx_t_2 = PyList_GET_ITEM(__pyx_t_10, __pyx_t_6); __Pyx_INCREF(__pyx_t_2); __pyx_t_6++;
+          __Pyx_DECREF(__pyx_v_allele);
+          __pyx_v_allele = __pyx_t_2;
+          __pyx_t_2 = 0;
+          __pyx_t_2 = PyNumber_Add(__pyx_v_addn, __pyx_v_allele); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1074; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_2);
+          if (unlikely(PyList_Append(__pyx_t_5, (PyObject*)__pyx_t_2))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1074; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        }
+        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+        __Pyx_INCREF(((PyObject *)__pyx_t_5));
+        __Pyx_DECREF(((PyObject *)__pyx_v_alt));
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+        __Pyx_DECREF(((PyObject *)__pyx_t_5)); __pyx_t_5 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1075
+ *                     ref = addn + ref
+ *                     alt = [addn + allele for allele in alt]
+ *                     pos -= 1             # <<<<<<<<<<<<<<
+ *         else:
+ *             # format v4.0 -- just check for nucleotides
+ */
+        __pyx_t_5 = PyNumber_InPlaceSubtract(__pyx_v_pos, __pyx_int_1); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1075; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __Pyx_DECREF(__pyx_v_pos);
+        __pyx_v_pos = __pyx_t_5;
+        __pyx_t_5 = 0;
+      }
+      __pyx_L43:;
+      goto __pyx_L42;
+    }
+    __pyx_L42:;
+    goto __pyx_L20;
+  }
+  /*else*/ {
+
+    /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1078
+ *         else:
+ *             # format v4.0 -- just check for nucleotides
+ *             for allele in alt:             # <<<<<<<<<<<<<<
+ *                 if not alleleRegEx.match(allele):
+ *                     self.error(str(record),self.V40_BAD_ALLELE,allele)
+ */
+    if (likely(((PyObject *)__pyx_v_alt) != Py_None)) {
+      __pyx_t_6 = 0; __pyx_t_5 = ((PyObject *)__pyx_v_alt); __Pyx_INCREF(__pyx_t_5);
+    } else {
+      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1078; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    }
+    for (;;) {
+      if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_5)) break;
+      __pyx_t_10 = PyList_GET_ITEM(__pyx_t_5, __pyx_t_6); __Pyx_INCREF(__pyx_t_10); __pyx_t_6++;
+      __Pyx_DECREF(__pyx_v_allele);
+      __pyx_v_allele = __pyx_t_10;
+      __pyx_t_10 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1079
+ *             # format v4.0 -- just check for nucleotides
+ *             for allele in alt:
+ *                 if not alleleRegEx.match(allele):             # <<<<<<<<<<<<<<
+ *                     self.error(str(record),self.V40_BAD_ALLELE,allele)
+ * 
+ */
+      __pyx_t_10 = __Pyx_GetName(__pyx_m, __pyx_n_s__alleleRegEx); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1079; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_10);
+      __pyx_t_2 = PyObject_GetAttr(__pyx_t_10, __pyx_n_s__match); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1079; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_2);
+      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+      __pyx_t_10 = PyTuple_New(1); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1079; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_10);
+      __Pyx_INCREF(__pyx_v_allele);
+      PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_v_allele);
+      __Pyx_GIVEREF(__pyx_v_allele);
+      __pyx_t_4 = PyObject_Call(__pyx_t_2, __pyx_t_10, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1079; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_4);
+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
+      __pyx_t_17 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_17 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1079; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+      __pyx_t_16 = (!__pyx_t_17);
+      if (__pyx_t_16) {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1080
+ *             for allele in alt:
+ *                 if not alleleRegEx.match(allele):
+ *                     self.error(str(record),self.V40_BAD_ALLELE,allele)             # <<<<<<<<<<<<<<
+ * 
+ * 
+ */
+        __pyx_t_4 = PyObject_GetAttr(__pyx_v_self, __pyx_n_s__error); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1080; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        __pyx_t_10 = PyTuple_New(1); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1080; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_10);
+        __Pyx_INCREF(__pyx_v_record);
+        PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_v_record);
+        __Pyx_GIVEREF(__pyx_v_record);
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+        __Pyx_GOTREF(__pyx_t_10);
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+    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1084
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+ *         for allele in alt:             # <<<<<<<<<<<<<<
+ *             if len(allele) != len(ref):
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+  }
+  for (;;) {
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+ *         # check for leading nucleotide in indel calls
+ *         for allele in alt:
+ *             if len(allele) != len(ref):             # <<<<<<<<<<<<<<
+ *                 if len(allele) == 0: self.error(str(record),self.ZERO_LENGTH_ALLELE)
+ *                 if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
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+    __pyx_t_12 = PyObject_Length(__pyx_v_allele); if (unlikely(__pyx_t_12 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1085; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __pyx_t_8 = PyObject_Length(__pyx_v_ref); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1085; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+    __pyx_t_16 = (__pyx_t_12 != __pyx_t_8);
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+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1086
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+ *                 if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
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+        __pyx_t_13 = PyObject_Call(__pyx_t_10, __pyx_t_2, NULL); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1086; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_13);
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+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1087
+ *             if len(allele) != len(ref):
+ *                 if len(allele) == 0: self.error(str(record),self.ZERO_LENGTH_ALLELE)
+ *                 if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():             # <<<<<<<<<<<<<<
+ *                     self.error(str(record),self.MISSING_INDEL_ALLELE_REF_BASE)
+ * 
+ */
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+      __Pyx_GOTREF(__pyx_t_13);
+      __pyx_t_2 = PyObject_GetAttr(__pyx_t_13, __pyx_n_s__upper); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1087; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_2);
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+      __Pyx_GOTREF(__pyx_t_13);
+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+      __Pyx_GOTREF(__pyx_t_2);
+      __pyx_t_10 = PyObject_GetAttr(__pyx_t_2, __pyx_n_s__upper); if (unlikely(!__pyx_t_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1087; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+      __Pyx_GOTREF(__pyx_t_10);
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+      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
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+        __Pyx_GOTREF(__pyx_t_10);
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+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_GOTREF(__pyx_t_13);
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+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_GOTREF(__pyx_t_13);
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+        __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
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+ *                 if len(allele) == 0: self.error(str(record),self.ZERO_LENGTH_ALLELE)
+ *                 if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
+ *                     self.error(str(record),self.MISSING_INDEL_ALLELE_REF_BASE)             # <<<<<<<<<<<<<<
+ * 
+ *         # trim trailing bases in alleles
+ */
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+        __Pyx_GOTREF(__pyx_t_13);
+        __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1088; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_2);
+        __Pyx_INCREF(__pyx_v_record);
+        PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_v_record);
+        __Pyx_GIVEREF(__pyx_v_record);
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+        __Pyx_GOTREF(__pyx_t_10);
+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
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+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_GOTREF(__pyx_t_4);
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+        __Pyx_GOTREF(__pyx_t_2);
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+        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+        goto __pyx_L55;
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+      __pyx_L55:;
+      goto __pyx_L53;
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+  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
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+ * 
+ *         # trim trailing bases in alleles
+ *         for i in range(1,min(len(ref),min(map(len,alt)))):             # <<<<<<<<<<<<<<
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+  __Pyx_GIVEREF(((PyObject *)__pyx_v_alt));
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+      __pyx_t_2 = PyObject_RichCompare(__pyx_v_left, __pyx_v_pos, Py_LT); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1098; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_2);
+      __pyx_t_16 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_16 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1098; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+      if (!__pyx_t_16) break;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1099
+ *         if self._leftalign and self._reference:
+ *             while left < pos:
+ *                 movable = True             # <<<<<<<<<<<<<<
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):
+ */
+      __pyx_v_movable = 1;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1100
+ *             while left < pos:
+ *                 movable = True
+ *                 for allele in alt:             # <<<<<<<<<<<<<<
+ *                     if len(allele) > len(ref):
+ *                         longest, shortest = allele, ref
+ */
+      if (likely(((PyObject *)__pyx_v_alt) != Py_None)) {
+        __pyx_t_6 = 0; __pyx_t_2 = ((PyObject *)__pyx_v_alt); __Pyx_INCREF(__pyx_t_2);
+      } else {
+        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1100; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      }
+      for (;;) {
+        if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_2)) break;
+        __pyx_t_5 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_6); __Pyx_INCREF(__pyx_t_5); __pyx_t_6++;
+        __Pyx_DECREF(__pyx_v_allele);
+        __pyx_v_allele = __pyx_t_5;
+        __pyx_t_5 = 0;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1101
+ *                 movable = True
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):             # <<<<<<<<<<<<<<
+ *                         longest, shortest = allele, ref
+ *                     else:
+ */
+        __pyx_t_8 = PyObject_Length(__pyx_v_allele); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1101; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_12 = PyObject_Length(__pyx_v_ref); if (unlikely(__pyx_t_12 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1101; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_16 = (__pyx_t_8 > __pyx_t_12);
+        if (__pyx_t_16) {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1102
+ *                 for allele in alt:
+ *                     if len(allele) > len(ref):
+ *                         longest, shortest = allele, ref             # <<<<<<<<<<<<<<
+ *                     else:
+ *                         longest, shortest = ref, allele
+ */
+          __pyx_t_5 = __pyx_v_allele;
+          __Pyx_INCREF(__pyx_t_5);
+          __pyx_t_13 = __pyx_v_ref;
+          __Pyx_INCREF(__pyx_t_13);
+          __Pyx_DECREF(__pyx_v_longest);
+          __pyx_v_longest = __pyx_t_5;
+          __pyx_t_5 = 0;
+          __Pyx_DECREF(__pyx_v_shortest);
+          __pyx_v_shortest = __pyx_t_13;
+          __pyx_t_13 = 0;
+          goto __pyx_L68;
+        }
+        /*else*/ {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1104
+ *                         longest, shortest = allele, ref
+ *                     else:
+ *                         longest, shortest = ref, allele             # <<<<<<<<<<<<<<
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False
+ */
+          __pyx_t_13 = __pyx_v_ref;
+          __Pyx_INCREF(__pyx_t_13);
+          __pyx_t_5 = __pyx_v_allele;
+          __Pyx_INCREF(__pyx_t_5);
+          __Pyx_DECREF(__pyx_v_longest);
+          __pyx_v_longest = __pyx_t_13;
+          __pyx_t_13 = 0;
+          __Pyx_DECREF(__pyx_v_shortest);
+          __pyx_v_shortest = __pyx_t_5;
+          __pyx_t_5 = 0;
+        }
+        __pyx_L68:;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1105
+ *                     else:
+ *                         longest, shortest = ref, allele
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():             # <<<<<<<<<<<<<<
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ */
+        __pyx_t_12 = PyObject_Length(__pyx_v_longest); if (unlikely(__pyx_t_12 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_8 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_16 = (__pyx_t_12 == __pyx_t_8);
+        if (!__pyx_t_16) {
+          __pyx_t_8 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __pyx_t_5 = PySequence_GetSlice(__pyx_v_longest, 0, __pyx_t_8); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_5);
+          __pyx_t_13 = PyObject_GetAttr(__pyx_t_5, __pyx_n_s__upper); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_13);
+          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+          __pyx_t_5 = PyObject_Call(__pyx_t_13, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_5);
+          __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+          __pyx_t_13 = PyObject_GetAttr(__pyx_v_shortest, __pyx_n_s__upper); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_13);
+          __pyx_t_4 = PyObject_Call(__pyx_t_13, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_4);
+          __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+          __pyx_t_13 = PyObject_RichCompare(__pyx_t_5, __pyx_t_4, Py_NE); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_GOTREF(__pyx_t_13);
+          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+          __pyx_t_17 = __Pyx_PyObject_IsTrue(__pyx_t_13); if (unlikely(__pyx_t_17 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1105; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+          __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+          __pyx_t_3 = __pyx_t_17;
+        } else {
+          __pyx_t_3 = __pyx_t_16;
+        }
+        if (__pyx_t_3) {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1106
+ *                         longest, shortest = ref, allele
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False             # <<<<<<<<<<<<<<
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False
+ */
+          __pyx_v_movable = 0;
+          goto __pyx_L69;
+        }
+        __pyx_L69:;
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1107
+ *                     if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():             # <<<<<<<<<<<<<<
+ *                         movable = False
+ *                 if not movable:
+ */
+        __pyx_t_13 = __Pyx_GetItemInt(__pyx_v_longest, -1, sizeof(long), PyInt_FromLong); if (!__pyx_t_13) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_13);
+        __pyx_t_4 = PyObject_GetAttr(__pyx_t_13, __pyx_n_s__upper); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+        __pyx_t_13 = PyObject_Call(__pyx_t_4, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_13);
+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+        __pyx_t_8 = PyObject_Length(__pyx_v_shortest); if (unlikely(__pyx_t_8 == -1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __pyx_t_12 = (__pyx_t_8 - 1);
+        __pyx_t_4 = __Pyx_GetItemInt(__pyx_v_longest, __pyx_t_12, sizeof(Py_ssize_t), PyInt_FromSsize_t); if (!__pyx_t_4) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        __pyx_t_5 = PyObject_GetAttr(__pyx_t_4, __pyx_n_s__upper); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+        __pyx_t_4 = PyObject_Call(__pyx_t_5, ((PyObject *)__pyx_empty_tuple), NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+        __pyx_t_5 = PyObject_RichCompare(__pyx_t_13, __pyx_t_4, Py_NE); if (unlikely(!__pyx_t_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_5);
+        __Pyx_DECREF(__pyx_t_13); __pyx_t_13 = 0;
+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+        __pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_3 < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1107; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+        if (__pyx_t_3) {
+
+          /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1108
+ *                         movable = False
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False             # <<<<<<<<<<<<<<
+ *                 if not movable:
+ *                     break
+ */
+          __pyx_v_movable = 0;
+          goto __pyx_L70;
+        }
+        __pyx_L70:;
+      }
+      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1109
+ *                     if longest[-1].upper() != longest[len(shortest)-1].upper():
+ *                         movable = False
+ *                 if not movable:             # <<<<<<<<<<<<<<
+ *                     break
+ *                 ref = ref[:-1]
+ */
+      __pyx_t_3 = (!__pyx_v_movable);
+      if (__pyx_t_3) {
+
+        /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1110
+ *                         movable = False
+ *                 if not movable:
+ *                     break             # <<<<<<<<<<<<<<
+ *                 ref = ref[:-1]
+ *                 alt = [allele[:-1] for allele in alt]
+ */
+        goto __pyx_L65_break;
+        goto __pyx_L71;
+      }
+      __pyx_L71:;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1111
+ *                 if not movable:
+ *                     break
+ *                 ref = ref[:-1]             # <<<<<<<<<<<<<<
+ *                 alt = [allele[:-1] for allele in alt]
+ *                 if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
+ */
+      __pyx_t_2 = PySequence_GetSlice(__pyx_v_ref, 0, -1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1111; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(__pyx_t_2);
+      __Pyx_DECREF(__pyx_v_ref);
+      __pyx_v_ref = __pyx_t_2;
+      __pyx_t_2 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1112
+ *                     break
+ *                 ref = ref[:-1]
+ *                 alt = [allele[:-1] for allele in alt]             # <<<<<<<<<<<<<<
+ *                 if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
+ *                     ref = faref_leftflank[pos-left-1] + ref
+ */
+      __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1112; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      __Pyx_GOTREF(((PyObject *)__pyx_t_2));
+      if (likely(((PyObject *)__pyx_v_alt) != Py_None)) {
+        __pyx_t_6 = 0; __pyx_t_5 = ((PyObject *)__pyx_v_alt); __Pyx_INCREF(__pyx_t_5);
+      } else {
+        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable"); {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1112; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+      }
+      for (;;) {
+        if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_5)) break;
+        __pyx_t_4 = PyList_GET_ITEM(__pyx_t_5, __pyx_t_6); __Pyx_INCREF(__pyx_t_4); __pyx_t_6++;
+        __Pyx_DECREF(__pyx_v_allele);
+        __pyx_v_allele = __pyx_t_4;
+        __pyx_t_4 = 0;
+        __pyx_t_4 = PySequence_GetSlice(__pyx_v_allele, 0, -1); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1112; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_GOTREF(__pyx_t_4);
+        if (unlikely(PyList_Append(__pyx_t_2, (PyObject*)__pyx_t_4))) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1112; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+      }
+      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
+      __Pyx_INCREF(((PyObject *)__pyx_t_2));
+      __Pyx_DECREF(((PyObject *)__pyx_v_alt));
+      __pyx_v_alt = __pyx_t_2;
+      __Pyx_DECREF(((PyObject *)__pyx_t_2)); __pyx_t_2 = 0;
+
+      /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":1113
+ *                 ref = ref[:-1]
+ *                 alt = [allele[:-1] for allele in alt]
+ *                 if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:             # <<<<<<<<<<<<<<
+ *                     ref = faref_leftflank[pos-left-1] + ref
+ *                     alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
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+static struct __pyx_vtabstruct_4cvcf_VCFRecord __pyx_vtable_4cvcf_VCFRecord;
+
+static PyObject *__pyx_tp_new_4cvcf_VCFRecord(PyTypeObject *t, PyObject *a, PyObject *k) {
+  struct __pyx_obj_4cvcf_VCFRecord *p;
+  PyObject *o = __pyx_ptype_10TabProxies_TupleProxy->tp_new(t, a, k);
+  if (!o) return 0;
+  p = ((struct __pyx_obj_4cvcf_VCFRecord *)o);
+  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_4cvcf_VCFRecord;
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+    Py_DECREF(o); o = 0;
+  }
+  return o;
+}
+
+static void __pyx_tp_dealloc_4cvcf_VCFRecord(PyObject *o) {
+  struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+  Py_XDECREF(p->vcf);
+  __pyx_ptype_10TabProxies_TupleProxy->tp_dealloc(o);
+}
+
+static int __pyx_tp_traverse_4cvcf_VCFRecord(PyObject *o, visitproc v, void *a) {
+  int e;
+  struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+  if (__pyx_ptype_10TabProxies_TupleProxy->tp_traverse) {
+    e = __pyx_ptype_10TabProxies_TupleProxy->tp_traverse(o, v, a); if (e) return e;
+  }
+  if (p->vcf) {
+    e = (*v)(p->vcf, a); if (e) return e;
+  }
+  return 0;
+}
+
+static int __pyx_tp_clear_4cvcf_VCFRecord(PyObject *o) {
+  struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+  PyObject* tmp;
+  if (__pyx_ptype_10TabProxies_TupleProxy->tp_clear) {
+    __pyx_ptype_10TabProxies_TupleProxy->tp_clear(o);
+  }
+  tmp = ((PyObject*)p->vcf);
+  p->vcf = Py_None; Py_INCREF(Py_None);
+  Py_XDECREF(tmp);
+  return 0;
+}
+static PyObject *__pyx_sq_item_4cvcf_VCFRecord(PyObject *o, Py_ssize_t i) {
+  PyObject *r;
+  PyObject *x = PyInt_FromSsize_t(i); if(!x) return 0;
+  r = Py_TYPE(o)->tp_as_mapping->mp_subscript(o, x);
+  Py_DECREF(x);
+  return r;
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_contig(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_6contig___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_pos(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_3pos___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_id(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_2id___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_ref(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_3ref___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_alt(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_3alt___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_qual(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_4qual___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_filter(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_6filter___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_info(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_4info___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_format(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_6format___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_samples(PyObject *o, void *x) {
+  return __pyx_pf_4cvcf_9VCFRecord_7samples___get__(o);
+}
+
+static PyMethodDef __pyx_methods_4cvcf_VCFRecord[] = {
+  {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_4cvcf_VCFRecord[] = {
+  {(char *)"contig", __pyx_getprop_4cvcf_9VCFRecord_contig, 0, 0, 0},
+  {(char *)"pos", __pyx_getprop_4cvcf_9VCFRecord_pos, 0, 0, 0},
+  {(char *)"id", __pyx_getprop_4cvcf_9VCFRecord_id, 0, 0, 0},
+  {(char *)"ref", __pyx_getprop_4cvcf_9VCFRecord_ref, 0, 0, 0},
+  {(char *)"alt", __pyx_getprop_4cvcf_9VCFRecord_alt, 0, 0, 0},
+  {(char *)"qual", __pyx_getprop_4cvcf_9VCFRecord_qual, 0, 0, 0},
+  {(char *)"filter", __pyx_getprop_4cvcf_9VCFRecord_filter, 0, 0, 0},
+  {(char *)"info", __pyx_getprop_4cvcf_9VCFRecord_info, 0, 0, 0},
+  {(char *)"format", __pyx_getprop_4cvcf_9VCFRecord_format, 0, 0, 0},
+  {(char *)"samples", __pyx_getprop_4cvcf_9VCFRecord_samples, 0, 0, 0},
+  {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_VCFRecord = {
+  0, /*nb_add*/
+  0, /*nb_subtract*/
+  0, /*nb_multiply*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_divide*/
+  #endif
+  0, /*nb_remainder*/
+  0, /*nb_divmod*/
+  0, /*nb_power*/
+  0, /*nb_negative*/
+  0, /*nb_positive*/
+  0, /*nb_absolute*/
+  0, /*nb_nonzero*/
+  0, /*nb_invert*/
+  0, /*nb_lshift*/
+  0, /*nb_rshift*/
+  0, /*nb_and*/
+  0, /*nb_xor*/
+  0, /*nb_or*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_coerce*/
+  #endif
+  0, /*nb_int*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_long*/
+  #else
+  0, /*reserved*/
+  #endif
+  0, /*nb_float*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_oct*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_hex*/
+  #endif
+  0, /*nb_inplace_add*/
+  0, /*nb_inplace_subtract*/
+  0, /*nb_inplace_multiply*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_inplace_divide*/
+  #endif
+  0, /*nb_inplace_remainder*/
+  0, /*nb_inplace_power*/
+  0, /*nb_inplace_lshift*/
+  0, /*nb_inplace_rshift*/
+  0, /*nb_inplace_and*/
+  0, /*nb_inplace_xor*/
+  0, /*nb_inplace_or*/
+  0, /*nb_floor_divide*/
+  0, /*nb_true_divide*/
+  0, /*nb_inplace_floor_divide*/
+  0, /*nb_inplace_true_divide*/
+  #if PY_VERSION_HEX >= 0x02050000
+  0, /*nb_index*/
+  #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_VCFRecord = {
+  __pyx_pf_4cvcf_9VCFRecord___len__, /*sq_length*/
+  0, /*sq_concat*/
+  0, /*sq_repeat*/
+  __pyx_sq_item_4cvcf_VCFRecord, /*sq_item*/
+  0, /*sq_slice*/
+  0, /*sq_ass_item*/
+  0, /*sq_ass_slice*/
+  0, /*sq_contains*/
+  0, /*sq_inplace_concat*/
+  0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_VCFRecord = {
+  __pyx_pf_4cvcf_9VCFRecord___len__, /*mp_length*/
+  __pyx_pf_4cvcf_9VCFRecord___getitem__, /*mp_subscript*/
+  0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_VCFRecord = {
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getreadbuffer*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getwritebuffer*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getsegcount*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getcharbuffer*/
+  #endif
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*bf_getbuffer*/
+  #endif
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*bf_releasebuffer*/
+  #endif
+};
+
+PyTypeObject __pyx_type_4cvcf_VCFRecord = {
+  PyVarObject_HEAD_INIT(0, 0)
+  __Pyx_NAMESTR("cvcf.VCFRecord"), /*tp_name*/
+  sizeof(struct __pyx_obj_4cvcf_VCFRecord), /*tp_basicsize*/
+  0, /*tp_itemsize*/
+  __pyx_tp_dealloc_4cvcf_VCFRecord, /*tp_dealloc*/
+  0, /*tp_print*/
+  0, /*tp_getattr*/
+  0, /*tp_setattr*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*tp_compare*/
+  #else
+  0, /*reserved*/
+  #endif
+  0, /*tp_repr*/
+  &__pyx_tp_as_number_VCFRecord, /*tp_as_number*/
+  &__pyx_tp_as_sequence_VCFRecord, /*tp_as_sequence*/
+  &__pyx_tp_as_mapping_VCFRecord, /*tp_as_mapping*/
+  0, /*tp_hash*/
+  0, /*tp_call*/
+  0, /*tp_str*/
+  0, /*tp_getattro*/
+  0, /*tp_setattro*/
+  &__pyx_tp_as_buffer_VCFRecord, /*tp_as_buffer*/
+  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+  __Pyx_DOCSTR("vcf record.\n\n    initialized from data and vcf meta \n    "), /*tp_doc*/
+  __pyx_tp_traverse_4cvcf_VCFRecord, /*tp_traverse*/
+  __pyx_tp_clear_4cvcf_VCFRecord, /*tp_clear*/
+  0, /*tp_richcompare*/
+  0, /*tp_weaklistoffset*/
+  0, /*tp_iter*/
+  0, /*tp_iternext*/
+  __pyx_methods_4cvcf_VCFRecord, /*tp_methods*/
+  0, /*tp_members*/
+  __pyx_getsets_4cvcf_VCFRecord, /*tp_getset*/
+  0, /*tp_base*/
+  0, /*tp_dict*/
+  0, /*tp_descr_get*/
+  0, /*tp_descr_set*/
+  0, /*tp_dictoffset*/
+  __pyx_pf_4cvcf_9VCFRecord___init__, /*tp_init*/
+  0, /*tp_alloc*/
+  __pyx_tp_new_4cvcf_VCFRecord, /*tp_new*/
+  0, /*tp_free*/
+  0, /*tp_is_gc*/
+  0, /*tp_bases*/
+  0, /*tp_mro*/
+  0, /*tp_cache*/
+  0, /*tp_subclasses*/
+  0, /*tp_weaklist*/
+  0, /*tp_del*/
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*tp_version_tag*/
+  #endif
+};
+
+static PyObject *__pyx_tp_new_4cvcf_asVCFRecord(PyTypeObject *t, PyObject *a, PyObject *k) {
+  struct __pyx_obj_4cvcf_asVCFRecord *p;
+  PyObject *o = __pyx_ptype_6ctabix_Parser->tp_new(t, a, k);
+  if (!o) return 0;
+  p = ((struct __pyx_obj_4cvcf_asVCFRecord *)o);
+  p->vcffile = Py_None; Py_INCREF(Py_None);
+  return o;
+}
+
+static void __pyx_tp_dealloc_4cvcf_asVCFRecord(PyObject *o) {
+  struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+  Py_XDECREF(p->vcffile);
+  __pyx_ptype_6ctabix_Parser->tp_dealloc(o);
+}
+
+static int __pyx_tp_traverse_4cvcf_asVCFRecord(PyObject *o, visitproc v, void *a) {
+  int e;
+  struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+  if (__pyx_ptype_6ctabix_Parser->tp_traverse) {
+    e = __pyx_ptype_6ctabix_Parser->tp_traverse(o, v, a); if (e) return e;
+  }
+  if (p->vcffile) {
+    e = (*v)(p->vcffile, a); if (e) return e;
+  }
+  return 0;
+}
+
+static int __pyx_tp_clear_4cvcf_asVCFRecord(PyObject *o) {
+  struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+  PyObject* tmp;
+  if (__pyx_ptype_6ctabix_Parser->tp_clear) {
+    __pyx_ptype_6ctabix_Parser->tp_clear(o);
+  }
+  tmp = ((PyObject*)p->vcffile);
+  p->vcffile = Py_None; Py_INCREF(Py_None);
+  Py_XDECREF(tmp);
+  return 0;
+}
+
+static PyMethodDef __pyx_methods_4cvcf_asVCFRecord[] = {
+  {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asVCFRecord = {
+  0, /*nb_add*/
+  0, /*nb_subtract*/
+  0, /*nb_multiply*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_divide*/
+  #endif
+  0, /*nb_remainder*/
+  0, /*nb_divmod*/
+  0, /*nb_power*/
+  0, /*nb_negative*/
+  0, /*nb_positive*/
+  0, /*nb_absolute*/
+  0, /*nb_nonzero*/
+  0, /*nb_invert*/
+  0, /*nb_lshift*/
+  0, /*nb_rshift*/
+  0, /*nb_and*/
+  0, /*nb_xor*/
+  0, /*nb_or*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_coerce*/
+  #endif
+  0, /*nb_int*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_long*/
+  #else
+  0, /*reserved*/
+  #endif
+  0, /*nb_float*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_oct*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_hex*/
+  #endif
+  0, /*nb_inplace_add*/
+  0, /*nb_inplace_subtract*/
+  0, /*nb_inplace_multiply*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*nb_inplace_divide*/
+  #endif
+  0, /*nb_inplace_remainder*/
+  0, /*nb_inplace_power*/
+  0, /*nb_inplace_lshift*/
+  0, /*nb_inplace_rshift*/
+  0, /*nb_inplace_and*/
+  0, /*nb_inplace_xor*/
+  0, /*nb_inplace_or*/
+  0, /*nb_floor_divide*/
+  0, /*nb_true_divide*/
+  0, /*nb_inplace_floor_divide*/
+  0, /*nb_inplace_true_divide*/
+  #if PY_VERSION_HEX >= 0x02050000
+  0, /*nb_index*/
+  #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asVCFRecord = {
+  0, /*sq_length*/
+  0, /*sq_concat*/
+  0, /*sq_repeat*/
+  0, /*sq_item*/
+  0, /*sq_slice*/
+  0, /*sq_ass_item*/
+  0, /*sq_ass_slice*/
+  0, /*sq_contains*/
+  0, /*sq_inplace_concat*/
+  0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asVCFRecord = {
+  0, /*mp_length*/
+  0, /*mp_subscript*/
+  0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asVCFRecord = {
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getreadbuffer*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getwritebuffer*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getsegcount*/
+  #endif
+  #if PY_MAJOR_VERSION < 3
+  0, /*bf_getcharbuffer*/
+  #endif
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*bf_getbuffer*/
+  #endif
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*bf_releasebuffer*/
+  #endif
+};
+
+PyTypeObject __pyx_type_4cvcf_asVCFRecord = {
+  PyVarObject_HEAD_INIT(0, 0)
+  __Pyx_NAMESTR("cvcf.asVCFRecord"), /*tp_name*/
+  sizeof(struct __pyx_obj_4cvcf_asVCFRecord), /*tp_basicsize*/
+  0, /*tp_itemsize*/
+  __pyx_tp_dealloc_4cvcf_asVCFRecord, /*tp_dealloc*/
+  0, /*tp_print*/
+  0, /*tp_getattr*/
+  0, /*tp_setattr*/
+  #if PY_MAJOR_VERSION < 3
+  0, /*tp_compare*/
+  #else
+  0, /*reserved*/
+  #endif
+  0, /*tp_repr*/
+  &__pyx_tp_as_number_asVCFRecord, /*tp_as_number*/
+  &__pyx_tp_as_sequence_asVCFRecord, /*tp_as_sequence*/
+  &__pyx_tp_as_mapping_asVCFRecord, /*tp_as_mapping*/
+  0, /*tp_hash*/
+  __pyx_pf_4cvcf_11asVCFRecord___call__, /*tp_call*/
+  0, /*tp_str*/
+  0, /*tp_getattro*/
+  0, /*tp_setattro*/
+  &__pyx_tp_as_buffer_asVCFRecord, /*tp_as_buffer*/
+  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+  __Pyx_DOCSTR("converts a :term:`tabix row` into a VCF record."), /*tp_doc*/
+  __pyx_tp_traverse_4cvcf_asVCFRecord, /*tp_traverse*/
+  __pyx_tp_clear_4cvcf_asVCFRecord, /*tp_clear*/
+  0, /*tp_richcompare*/
+  0, /*tp_weaklistoffset*/
+  0, /*tp_iter*/
+  0, /*tp_iternext*/
+  __pyx_methods_4cvcf_asVCFRecord, /*tp_methods*/
+  0, /*tp_members*/
+  0, /*tp_getset*/
+  0, /*tp_base*/
+  0, /*tp_dict*/
+  0, /*tp_descr_get*/
+  0, /*tp_descr_set*/
+  0, /*tp_dictoffset*/
+  __pyx_pf_4cvcf_11asVCFRecord___init__, /*tp_init*/
+  0, /*tp_alloc*/
+  __pyx_tp_new_4cvcf_asVCFRecord, /*tp_new*/
+  0, /*tp_free*/
+  0, /*tp_is_gc*/
+  0, /*tp_bases*/
+  0, /*tp_mro*/
+  0, /*tp_cache*/
+  0, /*tp_subclasses*/
+  0, /*tp_weaklist*/
+  0, /*tp_del*/
+  #if PY_VERSION_HEX >= 0x02060000
+  0, /*tp_version_tag*/
+  #endif
+};
+
+static PyMethodDef __pyx_methods[] = {
+  {__Pyx_NAMESTR("get_sequence"), (PyCFunction)__pyx_pf_4cvcf_get_sequence, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(0)},
+  {__Pyx_NAMESTR("parse_regions"), (PyCFunction)__pyx_pf_4cvcf_parse_regions, METH_O, __Pyx_DOCSTR(0)},
+  {0, 0, 0, 0}
+};
+
+#if PY_MAJOR_VERSION >= 3
+static struct PyModuleDef __pyx_moduledef = {
+    PyModuleDef_HEAD_INIT,
+    __Pyx_NAMESTR("cvcf"),
+    0, /* m_doc */
+    -1, /* m_size */
+    __pyx_methods /* m_methods */,
+    NULL, /* m_reload */
+    NULL, /* m_traverse */
+    NULL, /* m_clear */
+    NULL /* m_free */
+};
+#endif
+
+static __Pyx_StringTabEntry __pyx_string_tab[] = {
+  {&__pyx_kp_s_1, __pyx_k_1, sizeof(__pyx_k_1), 0, 0, 1, 0},
+  {&__pyx_kp_s_10, __pyx_k_10, sizeof(__pyx_k_10), 0, 0, 1, 0},
+  {&__pyx_kp_s_100, __pyx_k_100, sizeof(__pyx_k_100), 0, 0, 1, 0},
+  {&__pyx_kp_s_101, __pyx_k_101, sizeof(__pyx_k_101), 0, 0, 1, 0},
+  {&__pyx_kp_s_102, __pyx_k_102, sizeof(__pyx_k_102), 0, 0, 1, 0},
+  {&__pyx_kp_s_103, __pyx_k_103, sizeof(__pyx_k_103), 0, 0, 1, 0},
+  {&__pyx_kp_s_104, __pyx_k_104, sizeof(__pyx_k_104), 0, 0, 1, 0},
+  {&__pyx_kp_s_105, __pyx_k_105, sizeof(__pyx_k_105), 0, 0, 1, 0},
+  {&__pyx_kp_s_106, __pyx_k_106, sizeof(__pyx_k_106), 0, 0, 1, 0},
+  {&__pyx_kp_u_107, __pyx_k_107, sizeof(__pyx_k_107), 0, 1, 0, 0},
+  {&__pyx_kp_u_108, __pyx_k_108, sizeof(__pyx_k_108), 0, 1, 0, 0},
+  {&__pyx_kp_u_109, __pyx_k_109, sizeof(__pyx_k_109), 0, 1, 0, 0},
+  {&__pyx_n_s_11, __pyx_k_11, sizeof(__pyx_k_11), 0, 0, 1, 1},
+  {&__pyx_kp_u_110, __pyx_k_110, sizeof(__pyx_k_110), 0, 1, 0, 0},
+  {&__pyx_kp_u_111, __pyx_k_111, sizeof(__pyx_k_111), 0, 1, 0, 0},
+  {&__pyx_kp_u_112, __pyx_k_112, sizeof(__pyx_k_112), 0, 1, 0, 0},
+  {&__pyx_kp_u_113, __pyx_k_113, sizeof(__pyx_k_113), 0, 1, 0, 0},
+  {&__pyx_kp_u_114, __pyx_k_114, sizeof(__pyx_k_114), 0, 1, 0, 0},
+  {&__pyx_kp_u_115, __pyx_k_115, sizeof(__pyx_k_115), 0, 1, 0, 0},
+  {&__pyx_kp_u_116, __pyx_k_116, sizeof(__pyx_k_116), 0, 1, 0, 0},
+  {&__pyx_kp_u_117, __pyx_k_117, sizeof(__pyx_k_117), 0, 1, 0, 0},
+  {&__pyx_kp_u_118, __pyx_k_118, sizeof(__pyx_k_118), 0, 1, 0, 0},
+  {&__pyx_kp_u_119, __pyx_k_119, sizeof(__pyx_k_119), 0, 1, 0, 0},
+  {&__pyx_kp_s_12, __pyx_k_12, sizeof(__pyx_k_12), 0, 0, 1, 0},
+  {&__pyx_kp_u_120, __pyx_k_120, sizeof(__pyx_k_120), 0, 1, 0, 0},
+  {&__pyx_kp_u_121, __pyx_k_121, sizeof(__pyx_k_121), 0, 1, 0, 0},
+  {&__pyx_kp_u_122, __pyx_k_122, sizeof(__pyx_k_122), 0, 1, 0, 0},
+  {&__pyx_kp_u_123, __pyx_k_123, sizeof(__pyx_k_123), 0, 1, 0, 0},
+  {&__pyx_kp_u_124, __pyx_k_124, sizeof(__pyx_k_124), 0, 1, 0, 0},
+  {&__pyx_kp_s_14, __pyx_k_14, sizeof(__pyx_k_14), 0, 0, 1, 0},
+  {&__pyx_kp_s_16, __pyx_k_16, sizeof(__pyx_k_16), 0, 0, 1, 0},
+  {&__pyx_n_s_17, __pyx_k_17, sizeof(__pyx_k_17), 0, 0, 1, 1},
+  {&__pyx_kp_s_18, __pyx_k_18, sizeof(__pyx_k_18), 0, 0, 1, 0},
+  {&__pyx_kp_s_19, __pyx_k_19, sizeof(__pyx_k_19), 0, 0, 1, 0},
+  {&__pyx_kp_s_2, __pyx_k_2, sizeof(__pyx_k_2), 0, 0, 1, 0},
+  {&__pyx_n_s_20, __pyx_k_20, sizeof(__pyx_k_20), 0, 0, 1, 1},
+  {&__pyx_n_s_21, __pyx_k_21, sizeof(__pyx_k_21), 0, 0, 1, 1},
+  {&__pyx_kp_s_22, __pyx_k_22, sizeof(__pyx_k_22), 0, 0, 1, 0},
+  {&__pyx_kp_s_23, __pyx_k_23, sizeof(__pyx_k_23), 0, 0, 1, 0},
+  {&__pyx_kp_s_24, __pyx_k_24, sizeof(__pyx_k_24), 0, 0, 1, 0},
+  {&__pyx_kp_s_25, __pyx_k_25, sizeof(__pyx_k_25), 0, 0, 1, 0},
+  {&__pyx_n_s_26, __pyx_k_26, sizeof(__pyx_k_26), 0, 0, 1, 1},
+  {&__pyx_kp_s_27, __pyx_k_27, sizeof(__pyx_k_27), 0, 0, 1, 0},
+  {&__pyx_kp_s_28, __pyx_k_28, sizeof(__pyx_k_28), 0, 0, 1, 0},
+  {&__pyx_kp_s_29, __pyx_k_29, sizeof(__pyx_k_29), 0, 0, 1, 0},
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+  {&__pyx_n_s___warn_errors, __pyx_k___warn_errors, sizeof(__pyx_k___warn_errors), 0, 0, 1, 1},
+  {&__pyx_n_s__add, __pyx_k__add, sizeof(__pyx_k__add), 0, 0, 1, 1},
+  {&__pyx_n_s__alleleRegEx, __pyx_k__alleleRegEx, sizeof(__pyx_k__alleleRegEx), 0, 0, 1, 1},
+  {&__pyx_n_s__alt, __pyx_k__alt, sizeof(__pyx_k__alt), 0, 0, 1, 1},
+  {&__pyx_n_s__alt1, __pyx_k__alt1, sizeof(__pyx_k__alt1), 0, 0, 1, 1},
+  {&__pyx_n_s__alt2, __pyx_k__alt2, sizeof(__pyx_k__alt2), 0, 0, 1, 1},
+  {&__pyx_n_s__bisect, __pyx_k__bisect, sizeof(__pyx_k__bisect), 0, 0, 1, 1},
+  {&__pyx_n_s__buffer, __pyx_k__buffer, sizeof(__pyx_k__buffer), 0, 0, 1, 1},
+  {&__pyx_n_s__chrom, __pyx_k__chrom, sizeof(__pyx_k__chrom), 0, 0, 1, 1},
+  {&__pyx_n_s__collections, __pyx_k__collections, sizeof(__pyx_k__collections), 0, 0, 1, 1},
+  {&__pyx_n_s__compare_calls, __pyx_k__compare_calls, sizeof(__pyx_k__compare_calls), 0, 0, 1, 1},
+  {&__pyx_n_s__compile, __pyx_k__compile, sizeof(__pyx_k__compile), 0, 0, 1, 1},
+  {&__pyx_n_s__connect, __pyx_k__connect, sizeof(__pyx_k__connect), 0, 0, 1, 1},
+  {&__pyx_n_s__contig, __pyx_k__contig, sizeof(__pyx_k__contig), 0, 0, 1, 1},
+  {&__pyx_n_s__convertGT, __pyx_k__convertGT, sizeof(__pyx_k__convertGT), 0, 0, 1, 1},
+  {&__pyx_n_s__convertGTback, __pyx_k__convertGTback, sizeof(__pyx_k__convertGTback), 0, 0, 1, 1},
+  {&__pyx_n_s__copy, __pyx_k__copy, sizeof(__pyx_k__copy), 0, 0, 1, 1},
+  {&__pyx_n_s__data, __pyx_k__data, sizeof(__pyx_k__data), 0, 0, 1, 1},
+  {&__pyx_n_s__datagenerator, __pyx_k__datagenerator, sizeof(__pyx_k__datagenerator), 0, 0, 1, 1},
+  {&__pyx_n_s__deepcopy, __pyx_k__deepcopy, sizeof(__pyx_k__deepcopy), 0, 0, 1, 1},
+  {&__pyx_n_s__defaultdict, __pyx_k__defaultdict, sizeof(__pyx_k__defaultdict), 0, 0, 1, 1},
+  {&__pyx_n_s__descr, __pyx_k__descr, sizeof(__pyx_k__descr), 0, 0, 1, 1},
+  {&__pyx_n_s__description, __pyx_k__description, sizeof(__pyx_k__description), 0, 0, 1, 1},
+  {&__pyx_n_s__end, __pyx_k__end, sizeof(__pyx_k__end), 0, 0, 1, 1},
+  {&__pyx_n_s__endswith, __pyx_k__endswith, sizeof(__pyx_k__endswith), 0, 0, 1, 1},
+  {&__pyx_n_s__enumerate, __pyx_k__enumerate, sizeof(__pyx_k__enumerate), 0, 0, 1, 1},
+  {&__pyx_n_s__error, __pyx_k__error, sizeof(__pyx_k__error), 0, 0, 1, 1},
+  {&__pyx_n_s__errorstring, __pyx_k__errorstring, sizeof(__pyx_k__errorstring), 0, 0, 1, 1},
+  {&__pyx_n_s__fa, __pyx_k__fa, sizeof(__pyx_k__fa), 0, 0, 1, 1},
+  {&__pyx_n_s__fetch, __pyx_k__fetch, sizeof(__pyx_k__fetch), 0, 0, 1, 1},
+  {&__pyx_n_s__fields, __pyx_k__fields, sizeof(__pyx_k__fields), 0, 0, 1, 1},
+  {&__pyx_n_s__fileformat, __pyx_k__fileformat, sizeof(__pyx_k__fileformat), 0, 0, 1, 1},
+  {&__pyx_n_s__filename, __pyx_k__filename, sizeof(__pyx_k__filename), 0, 0, 1, 1},
+  {&__pyx_n_s__filter, __pyx_k__filter, sizeof(__pyx_k__filter), 0, 0, 1, 1},
+  {&__pyx_n_s__find, __pyx_k__find, sizeof(__pyx_k__find), 0, 0, 1, 1},
+  {&__pyx_n_s__fmt, __pyx_k__fmt, sizeof(__pyx_k__fmt), 0, 0, 1, 1},
+  {&__pyx_n_s__format, __pyx_k__format, sizeof(__pyx_k__format), 0, 0, 1, 1},
+  {&__pyx_n_s__format_format, __pyx_k__format_format, sizeof(__pyx_k__format_format), 0, 0, 1, 1},
+  {&__pyx_n_s__format_formatdata, __pyx_k__format_formatdata, sizeof(__pyx_k__format_formatdata), 0, 0, 1, 1},
+  {&__pyx_n_s__formatdict, __pyx_k__formatdict, sizeof(__pyx_k__formatdict), 0, 0, 1, 1},
+  {&__pyx_n_s__get, __pyx_k__get, sizeof(__pyx_k__get), 0, 0, 1, 1},
+  {&__pyx_n_s__get_expected, __pyx_k__get_expected, sizeof(__pyx_k__get_expected), 0, 0, 1, 1},
+  {&__pyx_n_s__get_sequence, __pyx_k__get_sequence, sizeof(__pyx_k__get_sequence), 0, 0, 1, 1},
+  {&__pyx_n_s__getfilter, __pyx_k__getfilter, sizeof(__pyx_k__getfilter), 0, 0, 1, 1},
+  {&__pyx_n_s__getformat, __pyx_k__getformat, sizeof(__pyx_k__getformat), 0, 0, 1, 1},
+  {&__pyx_n_s__getheader, __pyx_k__getheader, sizeof(__pyx_k__getheader), 0, 0, 1, 1},
+  {&__pyx_n_s__getinfo, __pyx_k__getinfo, sizeof(__pyx_k__getinfo), 0, 0, 1, 1},
+  {&__pyx_n_s__getsamples, __pyx_k__getsamples, sizeof(__pyx_k__getsamples), 0, 0, 1, 1},
+  {&__pyx_n_s__gtsRegEx, __pyx_k__gtsRegEx, sizeof(__pyx_k__gtsRegEx), 0, 0, 1, 1},
+  {&__pyx_n_s__header, __pyx_k__header, sizeof(__pyx_k__header), 0, 0, 1, 1},
+  {&__pyx_n_s__id, __pyx_k__id, sizeof(__pyx_k__id), 0, 0, 1, 1},
+  {&__pyx_n_s__ignoreerror, __pyx_k__ignoreerror, sizeof(__pyx_k__ignoreerror), 0, 0, 1, 1},
+  {&__pyx_n_s__info, __pyx_k__info, sizeof(__pyx_k__info), 0, 0, 1, 1},
+  {&__pyx_n_s__inregion, __pyx_k__inregion, sizeof(__pyx_k__inregion), 0, 0, 1, 1},
+  {&__pyx_n_s__itemgetter, __pyx_k__itemgetter, sizeof(__pyx_k__itemgetter), 0, 0, 1, 1},
+  {&__pyx_n_s__itervalues, __pyx_k__itervalues, sizeof(__pyx_k__itervalues), 0, 0, 1, 1},
+  {&__pyx_n_s__join, __pyx_k__join, sizeof(__pyx_k__join), 0, 0, 1, 1},
+  {&__pyx_n_s__key, __pyx_k__key, sizeof(__pyx_k__key), 0, 0, 1, 1},
+  {&__pyx_n_s__keys, __pyx_k__keys, sizeof(__pyx_k__keys), 0, 0, 1, 1},
+  {&__pyx_n_s__leftalign, __pyx_k__leftalign, sizeof(__pyx_k__leftalign), 0, 0, 1, 1},
+  {&__pyx_n_s__len, __pyx_k__len, sizeof(__pyx_k__len), 0, 0, 1, 1},
+  {&__pyx_n_s__line, __pyx_k__line, sizeof(__pyx_k__line), 0, 0, 1, 1},
+  {&__pyx_n_s__lineparse, __pyx_k__lineparse, sizeof(__pyx_k__lineparse), 0, 0, 1, 1},
+  {&__pyx_n_s__lines, __pyx_k__lines, sizeof(__pyx_k__lines), 0, 0, 1, 1},
+  {&__pyx_n_s__map, __pyx_k__map, sizeof(__pyx_k__map), 0, 0, 1, 1},
+  {&__pyx_n_s__match, __pyx_k__match, sizeof(__pyx_k__match), 0, 0, 1, 1},
+  {&__pyx_n_s__min, __pyx_k__min, sizeof(__pyx_k__min), 0, 0, 1, 1},
+  {&__pyx_n_s__missing, __pyx_k__missing, sizeof(__pyx_k__missing), 0, 0, 1, 1},
+  {&__pyx_n_s__missingvalue, __pyx_k__missingvalue, sizeof(__pyx_k__missingvalue), 0, 0, 1, 1},
+  {&__pyx_n_s__namedtuple, __pyx_k__namedtuple, sizeof(__pyx_k__namedtuple), 0, 0, 1, 1},
+  {&__pyx_n_s__nfields, __pyx_k__nfields, sizeof(__pyx_k__nfields), 0, 0, 1, 1},
+  {&__pyx_n_s__number, __pyx_k__number, sizeof(__pyx_k__number), 0, 0, 1, 1},
+  {&__pyx_n_s__numbertype, __pyx_k__numbertype, sizeof(__pyx_k__numbertype), 0, 0, 1, 1},
+  {&__pyx_n_s__object, __pyx_k__object, sizeof(__pyx_k__object), 0, 0, 1, 1},
+  {&__pyx_n_s__offset, __pyx_k__offset, sizeof(__pyx_k__offset), 0, 0, 1, 1},
+  {&__pyx_n_s__operator, __pyx_k__operator, sizeof(__pyx_k__operator), 0, 0, 1, 1},
+  {&__pyx_n_s__opt, __pyx_k__opt, sizeof(__pyx_k__opt), 0, 0, 1, 1},
+  {&__pyx_n_s__parse, __pyx_k__parse, sizeof(__pyx_k__parse), 0, 0, 1, 1},
+  {&__pyx_n_s__parse_data, __pyx_k__parse_data, sizeof(__pyx_k__parse_data), 0, 0, 1, 1},
+  {&__pyx_n_s__parse_format, __pyx_k__parse_format, sizeof(__pyx_k__parse_format), 0, 0, 1, 1},
+  {&__pyx_n_s__parse_formatdata, __pyx_k__parse_formatdata, sizeof(__pyx_k__parse_formatdata), 0, 0, 1, 1},
+  {&__pyx_n_s__parse_header, __pyx_k__parse_header, sizeof(__pyx_k__parse_header), 0, 0, 1, 1},
+  {&__pyx_n_s__parse_heading, __pyx_k__parse_heading, sizeof(__pyx_k__parse_heading), 0, 0, 1, 1},
+  {&__pyx_n_s__parser, __pyx_k__parser, sizeof(__pyx_k__parser), 0, 0, 1, 1},
+  {&__pyx_n_s__pos, __pyx_k__pos, sizeof(__pyx_k__pos), 0, 0, 1, 1},
+  {&__pyx_n_s__pos1, __pyx_k__pos1, sizeof(__pyx_k__pos1), 0, 0, 1, 1},
+  {&__pyx_n_s__pos2, __pyx_k__pos2, sizeof(__pyx_k__pos2), 0, 0, 1, 1},
+  {&__pyx_n_s__pysam, __pyx_k__pysam, sizeof(__pyx_k__pysam), 0, 0, 1, 1},
+  {&__pyx_n_s__qual, __pyx_k__qual, sizeof(__pyx_k__qual), 0, 0, 1, 1},
+  {&__pyx_n_s__range, __pyx_k__range, sizeof(__pyx_k__range), 0, 0, 1, 1},
+  {&__pyx_n_s__re, __pyx_k__re, sizeof(__pyx_k__re), 0, 0, 1, 1},
+  {&__pyx_n_s__record, __pyx_k__record, sizeof(__pyx_k__record), 0, 0, 1, 1},
+  {&__pyx_n_s__ref, __pyx_k__ref, sizeof(__pyx_k__ref), 0, 0, 1, 1},
+  {&__pyx_n_s__ref1, __pyx_k__ref1, sizeof(__pyx_k__ref1), 0, 0, 1, 1},
+  {&__pyx_n_s__ref2, __pyx_k__ref2, sizeof(__pyx_k__ref2), 0, 0, 1, 1},
+  {&__pyx_n_s__reference, __pyx_k__reference, sizeof(__pyx_k__reference), 0, 0, 1, 1},
+  {&__pyx_n_s__region, __pyx_k__region, sizeof(__pyx_k__region), 0, 0, 1, 1},
+  {&__pyx_n_s__regions, __pyx_k__regions, sizeof(__pyx_k__regions), 0, 0, 1, 1},
+  {&__pyx_n_s__replace, __pyx_k__replace, sizeof(__pyx_k__replace), 0, 0, 1, 1},
+  {&__pyx_n_s__samples, __pyx_k__samples, sizeof(__pyx_k__samples), 0, 0, 1, 1},
+  {&__pyx_n_s__self, __pyx_k__self, sizeof(__pyx_k__self), 0, 0, 1, 1},
+  {&__pyx_n_s__separator, __pyx_k__separator, sizeof(__pyx_k__separator), 0, 0, 1, 1},
+  {&__pyx_n_s__setfilter, __pyx_k__setfilter, sizeof(__pyx_k__setfilter), 0, 0, 1, 1},
+  {&__pyx_n_s__setformat, __pyx_k__setformat, sizeof(__pyx_k__setformat), 0, 0, 1, 1},
+  {&__pyx_n_s__setheader, __pyx_k__setheader, sizeof(__pyx_k__setheader), 0, 0, 1, 1},
+  {&__pyx_n_s__setinfo, __pyx_k__setinfo, sizeof(__pyx_k__setinfo), 0, 0, 1, 1},
+  {&__pyx_n_s__setreference, __pyx_k__setreference, sizeof(__pyx_k__setreference), 0, 0, 1, 1},
+  {&__pyx_n_s__setregions, __pyx_k__setregions, sizeof(__pyx_k__setregions), 0, 0, 1, 1},
+  {&__pyx_n_s__setsamples, __pyx_k__setsamples, sizeof(__pyx_k__setsamples), 0, 0, 1, 1},
+  {&__pyx_n_s__setversion, __pyx_k__setversion, sizeof(__pyx_k__setversion), 0, 0, 1, 1},
+  {&__pyx_n_s__split, __pyx_k__split, sizeof(__pyx_k__split), 0, 0, 1, 1},
+  {&__pyx_n_s__start, __pyx_k__start, sizeof(__pyx_k__start), 0, 0, 1, 1},
+  {&__pyx_n_s__startswith, __pyx_k__startswith, sizeof(__pyx_k__startswith), 0, 0, 1, 1},
+  {&__pyx_n_s__stderr, __pyx_k__stderr, sizeof(__pyx_k__stderr), 0, 0, 1, 1},
+  {&__pyx_n_s__stream, __pyx_k__stream, sizeof(__pyx_k__stream), 0, 0, 1, 1},
+  {&__pyx_n_s__strip, __pyx_k__strip, sizeof(__pyx_k__strip), 0, 0, 1, 1},
+  {&__pyx_n_s__sys, __pyx_k__sys, sizeof(__pyx_k__sys), 0, 0, 1, 1},
+  {&__pyx_n_s__tabixfile, __pyx_k__tabixfile, sizeof(__pyx_k__tabixfile), 0, 0, 1, 1},
+  {&__pyx_n_s__type, __pyx_k__type, sizeof(__pyx_k__type), 0, 0, 1, 1},
+  {&__pyx_n_s__upper, __pyx_k__upper, sizeof(__pyx_k__upper), 0, 0, 1, 1},
+  {&__pyx_n_s__validate, __pyx_k__validate, sizeof(__pyx_k__validate), 0, 0, 1, 1},
+  {&__pyx_n_s__value, __pyx_k__value, sizeof(__pyx_k__value), 0, 0, 1, 1},
+  {&__pyx_n_s__vcf, __pyx_k__vcf, sizeof(__pyx_k__vcf), 0, 0, 1, 1},
+  {&__pyx_n_s__vcffile, __pyx_k__vcffile, sizeof(__pyx_k__vcffile), 0, 0, 1, 1},
+  {&__pyx_n_s__version, __pyx_k__version, sizeof(__pyx_k__version), 0, 0, 1, 1},
+  {&__pyx_n_s__warnerror, __pyx_k__warnerror, sizeof(__pyx_k__warnerror), 0, 0, 1, 1},
+  {&__pyx_n_s__write, __pyx_k__write, sizeof(__pyx_k__write), 0, 0, 1, 1},
+  {&__pyx_n_s__write_data, __pyx_k__write_data, sizeof(__pyx_k__write_data), 0, 0, 1, 1},
+  {&__pyx_n_s__write_header, __pyx_k__write_header, sizeof(__pyx_k__write_header), 0, 0, 1, 1},
+  {&__pyx_n_s__write_heading, __pyx_k__write_heading, sizeof(__pyx_k__write_heading), 0, 0, 1, 1},
+  {&__pyx_n_s__writeheader, __pyx_k__writeheader, sizeof(__pyx_k__writeheader), 0, 0, 1, 1},
+  {&__pyx_n_s__zip, __pyx_k__zip, sizeof(__pyx_k__zip), 0, 0, 1, 1},
+  {0, 0, 0, 0, 0, 0, 0}
+};
+static int __Pyx_InitCachedBuiltins(void) {
+  __pyx_builtin_object = __Pyx_GetName(__pyx_b, __pyx_n_s__object); if (!__pyx_builtin_object) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 232; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_ValueError = __Pyx_GetName(__pyx_b, __pyx_n_s__ValueError); if (!__pyx_builtin_ValueError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 77; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_range = __Pyx_GetName(__pyx_b, __pyx_n_s__range); if (!__pyx_builtin_range) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 204; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_enumerate = __Pyx_GetName(__pyx_b, __pyx_n_s__enumerate); if (!__pyx_builtin_enumerate) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 455; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_map = __Pyx_GetName(__pyx_b, __pyx_n_s__map); if (!__pyx_builtin_map) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 462; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_min = __Pyx_GetName(__pyx_b, __pyx_n_s__min); if (!__pyx_builtin_min) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 758; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_len = __Pyx_GetName(__pyx_b, __pyx_n_s__len); if (!__pyx_builtin_len) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 758; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_zip = __Pyx_GetName(__pyx_b, __pyx_n_s__zip); if (!__pyx_builtin_zip) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 816; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_StopIteration = __Pyx_GetName(__pyx_b, __pyx_n_s__StopIteration); if (!__pyx_builtin_StopIteration) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 870; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_KeyError = __Pyx_GetName(__pyx_b, __pyx_n_s__KeyError); if (!__pyx_builtin_KeyError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 933; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_builtin_NotImplementedError = __Pyx_GetName(__pyx_b, __pyx_n_s__NotImplementedError); if (!__pyx_builtin_NotImplementedError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 999; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  return 0;
+  __pyx_L1_error:;
+  return -1;
+}
+
+static int __Pyx_InitGlobals(void) {
+  #if PY_VERSION_HEX < 0x02040000
+  if (unlikely(__Pyx_Py23SetsImport() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  #endif
+  if (__Pyx_InitStrings(__pyx_string_tab) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_0 = PyInt_FromLong(0); if (unlikely(!__pyx_int_0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_1 = PyInt_FromLong(1); if (unlikely(!__pyx_int_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_2 = PyInt_FromLong(2); if (unlikely(!__pyx_int_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_3 = PyInt_FromLong(3); if (unlikely(!__pyx_int_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_4 = PyInt_FromLong(4); if (unlikely(!__pyx_int_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_5 = PyInt_FromLong(5); if (unlikely(!__pyx_int_5)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_6 = PyInt_FromLong(6); if (unlikely(!__pyx_int_6)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_7 = PyInt_FromLong(7); if (unlikely(!__pyx_int_7)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_8 = PyInt_FromLong(8); if (unlikely(!__pyx_int_8)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_9 = PyInt_FromLong(9); if (unlikely(!__pyx_int_9)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_neg_1 = PyInt_FromLong(-1); if (unlikely(!__pyx_int_neg_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_10 = PyInt_FromLong(10); if (unlikely(!__pyx_int_10)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_11 = PyInt_FromLong(11); if (unlikely(!__pyx_int_11)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_12 = PyInt_FromLong(12); if (unlikely(!__pyx_int_12)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_13 = PyInt_FromLong(13); if (unlikely(!__pyx_int_13)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_14 = PyInt_FromLong(14); if (unlikely(!__pyx_int_14)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_15 = PyInt_FromLong(15); if (unlikely(!__pyx_int_15)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_16 = PyInt_FromLong(16); if (unlikely(!__pyx_int_16)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_17 = PyInt_FromLong(17); if (unlikely(!__pyx_int_17)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_18 = PyInt_FromLong(18); if (unlikely(!__pyx_int_18)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_19 = PyInt_FromLong(19); if (unlikely(!__pyx_int_19)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_20 = PyInt_FromLong(20); if (unlikely(!__pyx_int_20)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_21 = PyInt_FromLong(21); if (unlikely(!__pyx_int_21)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_22 = PyInt_FromLong(22); if (unlikely(!__pyx_int_22)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_23 = PyInt_FromLong(23); if (unlikely(!__pyx_int_23)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_24 = PyInt_FromLong(24); if (unlikely(!__pyx_int_24)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_25 = PyInt_FromLong(25); if (unlikely(!__pyx_int_25)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_26 = PyInt_FromLong(26); if (unlikely(!__pyx_int_26)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_27 = PyInt_FromLong(27); if (unlikely(!__pyx_int_27)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_28 = PyInt_FromLong(28); if (unlikely(!__pyx_int_28)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_29 = PyInt_FromLong(29); if (unlikely(!__pyx_int_29)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_30 = PyInt_FromLong(30); if (unlikely(!__pyx_int_30)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_33 = PyInt_FromLong(33); if (unlikely(!__pyx_int_33)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_40 = PyInt_FromLong(40); if (unlikely(!__pyx_int_40)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_100 = PyInt_FromLong(100); if (unlikely(!__pyx_int_100)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  __pyx_int_3000000000 = PyInt_FromString((char *)"3000000000", 0, 0); if (unlikely(!__pyx_int_3000000000)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  return 0;
+  __pyx_L1_error:;
+  return -1;
+}
+
+#if PY_MAJOR_VERSION < 3
+PyMODINIT_FUNC initcvcf(void); /*proto*/
+PyMODINIT_FUNC initcvcf(void)
+#else
+PyMODINIT_FUNC PyInit_cvcf(void); /*proto*/
+PyMODINIT_FUNC PyInit_cvcf(void)
+#endif
+{
+  PyObject *__pyx_t_1 = NULL;
+  PyObject *__pyx_t_2 = NULL;
+  PyObject *__pyx_t_3 = NULL;
+  PyObject *__pyx_t_4 = NULL;
+  #if CYTHON_REFNANNY
+  void* __pyx_refnanny = NULL;
+  __Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
+  if (!__Pyx_RefNanny) {
+      PyErr_Clear();
+      __Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
+      if (!__Pyx_RefNanny)
+          Py_FatalError("failed to import 'refnanny' module");
+  }
+  __pyx_refnanny = __Pyx_RefNanny->SetupContext("PyMODINIT_FUNC PyInit_cvcf(void)", __LINE__, __FILE__);
+  #endif
+  __pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  #ifdef __pyx_binding_PyCFunctionType_USED
+  if (__pyx_binding_PyCFunctionType_init() < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  #endif
+  /*--- Library function declarations ---*/
+  /*--- Threads initialization code ---*/
+  #if defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
+  #ifdef WITH_THREAD /* Python build with threading support? */
+  PyEval_InitThreads();
+  #endif
+  #endif
+  /*--- Module creation code ---*/
+  #if PY_MAJOR_VERSION < 3
+  __pyx_m = Py_InitModule4(__Pyx_NAMESTR("cvcf"), __pyx_methods, 0, 0, PYTHON_API_VERSION);
+  #else
+  __pyx_m = PyModule_Create(&__pyx_moduledef);
+  #endif
+  if (!__pyx_m) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  #if PY_MAJOR_VERSION < 3
+  Py_INCREF(__pyx_m);
+  #endif
+  __pyx_b = PyImport_AddModule(__Pyx_NAMESTR(__Pyx_BUILTIN_MODULE_NAME));
+  if (!__pyx_b) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  if (__Pyx_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  /*--- Initialize various global constants etc. ---*/
+  if (unlikely(__Pyx_InitGlobals() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__pyx_module_is_main_cvcf) {
+    if (__Pyx_SetAttrString(__pyx_m, "__name__", __pyx_n_s____main__) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+  }
+  /*--- Builtin init code ---*/
+  if (unlikely(__Pyx_InitCachedBuiltins() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  /*--- Global init code ---*/
+  /*--- Function export code ---*/
+  /*--- Type init code ---*/
+  __pyx_ptype_10TabProxies_TupleProxy = __Pyx_ImportType("TabProxies", "TupleProxy", sizeof(struct __pyx_obj_10TabProxies_TupleProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_TupleProxy)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_TupleProxy->tp_dict, &__pyx_vtabptr_10TabProxies_TupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_vtabptr_4cvcf_VCFRecord = &__pyx_vtable_4cvcf_VCFRecord;
+  __pyx_vtable_4cvcf_VCFRecord.__pyx_base = *__pyx_vtabptr_10TabProxies_TupleProxy;
+  #if PY_MAJOR_VERSION >= 3
+  __pyx_vtable_4cvcf_VCFRecord.__pyx_base.update = (PyObject *(*)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t))__pyx_f_4cvcf_9VCFRecord_update;
+  #else
+  *(void(**)(void))&__pyx_vtable_4cvcf_VCFRecord.__pyx_base.update = (void(*)(void))__pyx_f_4cvcf_9VCFRecord_update;
+  #endif
+  __pyx_type_4cvcf_VCFRecord.tp_base = __pyx_ptype_10TabProxies_TupleProxy;
+  if (PyType_Ready(&__pyx_type_4cvcf_VCFRecord) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 94; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_SetVtable(__pyx_type_4cvcf_VCFRecord.tp_dict, __pyx_vtabptr_4cvcf_VCFRecord) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 94; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_SetAttrString(__pyx_m, "VCFRecord", (PyObject *)&__pyx_type_4cvcf_VCFRecord) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 94; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_4cvcf_VCFRecord = &__pyx_type_4cvcf_VCFRecord;
+  __pyx_ptype_6ctabix_Parser = __Pyx_ImportType("ctabix", "Parser", sizeof(struct __pyx_obj_6ctabix_Parser), 1); if (unlikely(!__pyx_ptype_6ctabix_Parser)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_type_4cvcf_asVCFRecord.tp_base = __pyx_ptype_6ctabix_Parser;
+  if (PyType_Ready(&__pyx_type_4cvcf_asVCFRecord) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 221; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_SetAttrString(__pyx_m, "asVCFRecord", (PyObject *)&__pyx_type_4cvcf_asVCFRecord) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 221; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_4cvcf_asVCFRecord = &__pyx_type_4cvcf_asVCFRecord;
+  /*--- Type import code ---*/
+  __pyx_ptype_6ctabix_Tabixfile = __Pyx_ImportType("ctabix", "Tabixfile", sizeof(struct __pyx_obj_6ctabix_Tabixfile), 1); if (unlikely(!__pyx_ptype_6ctabix_Tabixfile)) {__pyx_filename = __pyx_f[1]; __pyx_lineno = 172; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_10TabProxies_GTFProxy = __Pyx_ImportType("TabProxies", "GTFProxy", sizeof(struct __pyx_obj_10TabProxies_GTFProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_GTFProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_GTFProxy->tp_dict, &__pyx_vtabptr_10TabProxies_GTFProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_10TabProxies_NamedTupleProxy = __Pyx_ImportType("TabProxies", "NamedTupleProxy", sizeof(struct __pyx_obj_10TabProxies_NamedTupleProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_NamedTupleProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 77; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_NamedTupleProxy->tp_dict, &__pyx_vtabptr_10TabProxies_NamedTupleProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 77; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_10TabProxies_BedProxy = __Pyx_ImportType("TabProxies", "BedProxy", sizeof(struct __pyx_obj_10TabProxies_BedProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_BedProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 80; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_BedProxy->tp_dict, &__pyx_vtabptr_10TabProxies_BedProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 80; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __pyx_ptype_10TabProxies_VCFProxy = __Pyx_ImportType("TabProxies", "VCFProxy", sizeof(struct __pyx_obj_10TabProxies_VCFProxy), 1); if (unlikely(!__pyx_ptype_10TabProxies_VCFProxy)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 91; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (__Pyx_GetVtable(__pyx_ptype_10TabProxies_VCFProxy->tp_dict, &__pyx_vtabptr_10TabProxies_VCFProxy) < 0) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 91; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  /*--- Function import code ---*/
+  /*--- Execution code ---*/
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":46
+ * #
+ * 
+ * from collections import namedtuple, defaultdict             # <<<<<<<<<<<<<<
+ * from operator import itemgetter
+ * import sys, re, copy, bisect
+ */
+  __pyx_t_1 = PyList_New(2); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 46; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__namedtuple));
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+ * 
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+ * from operator import itemgetter             # <<<<<<<<<<<<<<
+ * import sys, re, copy, bisect
+ * 
+ */
+  __pyx_t_2 = PyList_New(1); if (unlikely(!__pyx_t_2)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 47; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+  __Pyx_INCREF(((PyObject *)__pyx_n_s__itemgetter));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__itemgetter));
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+  __Pyx_GOTREF(__pyx_t_2);
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+ * from collections import namedtuple, defaultdict
+ * from operator import itemgetter
+ * import sys, re, copy, bisect             # <<<<<<<<<<<<<<
+ * 
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+ */
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __Pyx_GOTREF(__pyx_t_1);
+  if (PyObject_SetAttr(__pyx_m, __pyx_n_s__bisect, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 48; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":52
+ * cimport ctabix
+ * cimport TabProxies
+ * import pysam             # <<<<<<<<<<<<<<
+ * 
+ * gtsRegEx = re.compile("[|/\\\\]")
+ */
+  __pyx_t_1 = __Pyx_Import(((PyObject *)__pyx_n_s__pysam), 0); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 52; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_1);
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":54
+ * import pysam
+ * 
+ * gtsRegEx = re.compile("[|/\\\\]")             # <<<<<<<<<<<<<<
+ * alleleRegEx = re.compile('^[ACGTN]+$')
+ * 
+ */
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+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+  __Pyx_INCREF(((PyObject *)__pyx_kp_s_73));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_73));
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+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ * 
+ * gtsRegEx = re.compile("[|/\\\\]")
+ * alleleRegEx = re.compile('^[ACGTN]+$')             # <<<<<<<<<<<<<<
+ * 
+ * # Utility function.  Uses 0-based coordinates
+ */
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+  __Pyx_GOTREF(__pyx_t_1);
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+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_74));
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+ * 
+ * 
+ * FORMAT = namedtuple('FORMAT','id numbertype number type description missingvalue')             # <<<<<<<<<<<<<<
+ * 
+ * ###########################################################################################################
+ */
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+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__FORMAT));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__FORMAT));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_kp_s_75));
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+  __Pyx_GOTREF(__pyx_t_1);
+  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_m, __pyx_n_s__FORMAT, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 86; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ *         return r
+ * 
+ * class VCF(object):             # <<<<<<<<<<<<<<
+ * 
+ *     # types
+ */
+  __pyx_t_1 = PyDict_New(); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 232; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
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+  __Pyx_GOTREF(__pyx_t_2);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ * 
+ *     # types
+ *     NT_UNKNOWN = 0             # <<<<<<<<<<<<<<
+ *     NT_NUMBER = 1
+ *     NT_ALLELES = 2
+ */
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+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":236
+ *     # types
+ *     NT_UNKNOWN = 0
+ *     NT_NUMBER = 1             # <<<<<<<<<<<<<<
+ *     NT_ALLELES = 2
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+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":237
+ *     NT_UNKNOWN = 0
+ *     NT_NUMBER = 1
+ *     NT_ALLELES = 2             # <<<<<<<<<<<<<<
+ *     NT_NR_ALLELES = 3
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+ */
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+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":238
+ *     NT_NUMBER = 1
+ *     NT_ALLELES = 2
+ *     NT_NR_ALLELES = 3             # <<<<<<<<<<<<<<
+ *     NT_GENOTYPES = 4
+ *     NT_PHASED_GENOTYPES = 5
+ */
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":239
+ *     NT_ALLELES = 2
+ *     NT_NR_ALLELES = 3
+ *     NT_GENOTYPES = 4             # <<<<<<<<<<<<<<
+ *     NT_PHASED_GENOTYPES = 5
+ * 
+ */
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+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":240
+ *     NT_NR_ALLELES = 3
+ *     NT_GENOTYPES = 4
+ *     NT_PHASED_GENOTYPES = 5             # <<<<<<<<<<<<<<
+ * 
+ *     _errors = { 0:"UNKNOWN_FORMAT_STRING:Unknown file format identifier",
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+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__NT_PHASED_GENOTYPES, __pyx_int_5) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 240; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":242
+ *     NT_PHASED_GENOTYPES = 5
+ * 
+ *     _errors = { 0:"UNKNOWN_FORMAT_STRING:Unknown file format identifier",             # <<<<<<<<<<<<<<
+ *                 1:"BADLY_FORMATTED_FORMAT_STRING:Formatting error in the format string",
+ *                 2:"BADLY_FORMATTED_HEADING:Did not find 9 required headings (CHROM, POS, ..., FORMAT) %s",
+ */
+  __pyx_t_3 = PyDict_New(); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_0, ((PyObject *)__pyx_kp_s_76)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_1, ((PyObject *)__pyx_kp_s_77)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_2, ((PyObject *)__pyx_kp_s_78)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_3, ((PyObject *)__pyx_kp_s_79)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_4, ((PyObject *)__pyx_kp_s_80)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_5, ((PyObject *)__pyx_kp_s_81)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_6, ((PyObject *)__pyx_kp_s_82)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_7, ((PyObject *)__pyx_kp_s_83)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_8, ((PyObject *)__pyx_kp_s_84)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_9, ((PyObject *)__pyx_kp_s_85)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_10, ((PyObject *)__pyx_kp_s_86)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_11, ((PyObject *)__pyx_kp_s_87)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_12, ((PyObject *)__pyx_kp_s_88)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_13, ((PyObject *)__pyx_kp_s_89)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_15, ((PyObject *)__pyx_kp_s_91)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_21, ((PyObject *)__pyx_kp_s_97)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_22, ((PyObject *)__pyx_kp_s_98)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_23, ((PyObject *)__pyx_kp_s_99)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_24, ((PyObject *)__pyx_kp_s_100)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_25, ((PyObject *)__pyx_kp_s_101)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_26, ((PyObject *)__pyx_kp_s_102)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_27, ((PyObject *)__pyx_kp_s_103)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_28, ((PyObject *)__pyx_kp_s_104)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_29, ((PyObject *)__pyx_kp_s_105)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyDict_SetItem(__pyx_t_3, __pyx_int_30, ((PyObject *)__pyx_kp_s_106)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___errors, ((PyObject *)__pyx_t_3)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 242; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":276
+ * 
+ *     # tag-value pairs; tags are not unique; does not include fileformat, INFO, FILTER or FORMAT fields
+ *     _header = []             # <<<<<<<<<<<<<<
+ * 
+ *     # version number; 33=v3.3; 40=v4.0
+ */
+  __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 276; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___header, ((PyObject *)__pyx_t_3)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 276; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":279
+ * 
+ *     # version number; 33=v3.3; 40=v4.0
+ *     _version = 40             # <<<<<<<<<<<<<<
+ * 
+ *     # info, filter and format data
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___version, __pyx_int_40) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 279; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":282
+ * 
+ *     # info, filter and format data
+ *     _info = {}             # <<<<<<<<<<<<<<
+ *     _filter = {}
+ *     _format = {}
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+  __pyx_t_3 = PyDict_New(); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 282; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
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+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":283
+ *     # info, filter and format data
+ *     _info = {}
+ *     _filter = {}             # <<<<<<<<<<<<<<
+ *     _format = {}
+ * 
+ */
+  __pyx_t_3 = PyDict_New(); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 283; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
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+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":284
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+ *     _filter = {}
+ *     _format = {}             # <<<<<<<<<<<<<<
+ * 
+ *     # header; and required columns
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
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+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
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+ * 
+ *     # header; and required columns
+ *     _required = ["CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO","FORMAT"]             # <<<<<<<<<<<<<<
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__CHROM));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__POS));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__POS));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__ID));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__ID));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__REF));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__REF));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__ALT));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__QUAL));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__QUAL));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__FILTER));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__FILTER));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__INFO));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__INFO));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__FORMAT));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__FORMAT));
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___required, ((PyObject *)__pyx_t_3)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 287; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ *     _required = ["CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO","FORMAT"]
+ *     _samples = []             # <<<<<<<<<<<<<<
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+ *     # control behaviour
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
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+  __Pyx_DECREF(((PyObject *)__pyx_t_3)); __pyx_t_3 = 0;
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+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":291
+ * 
+ *     # control behaviour
+ *     _ignored_errors = set([11])   # ERROR_UNKNOWN_KEY             # <<<<<<<<<<<<<<
+ *     _warn_errors = set([])
+ *     _leftalign = False
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
+  __Pyx_INCREF(__pyx_int_11);
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+  __Pyx_GIVEREF(__pyx_int_11);
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+  __Pyx_GOTREF(__pyx_t_4);
+  PyTuple_SET_ITEM(__pyx_t_4, 0, ((PyObject *)__pyx_t_3));
+  __Pyx_GIVEREF(((PyObject *)__pyx_t_3));
+  __pyx_t_3 = 0;
+  __pyx_t_3 = PyObject_Call(((PyObject *)((PyObject*)&PySet_Type)), __pyx_t_4, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 291; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ *     _warn_errors = set([])             # <<<<<<<<<<<<<<
+ *     _leftalign = False
+ * 
+ */
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_3));
+  __pyx_t_4 = PyTuple_New(1); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  PyTuple_SET_ITEM(__pyx_t_4, 0, ((PyObject *)__pyx_t_3));
+  __Pyx_GIVEREF(((PyObject *)__pyx_t_3));
+  __pyx_t_3 = 0;
+  __pyx_t_3 = PyObject_Call(((PyObject *)((PyObject*)&PySet_Type)), __pyx_t_4, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___warn_errors, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":293
+ *     _ignored_errors = set([11])   # ERROR_UNKNOWN_KEY
+ *     _warn_errors = set([])
+ *     _leftalign = False             # <<<<<<<<<<<<<<
+ * 
+ *     # reference sequence
+ */
+  __pyx_t_3 = __Pyx_PyBool_FromLong(0); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 293; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___leftalign, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 293; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":296
+ * 
+ *     # reference sequence
+ *     _reference = None             # <<<<<<<<<<<<<<
+ * 
+ *     # regions to include; None includes everything
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___reference, Py_None) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 296; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":299
+ * 
+ *     # regions to include; None includes everything
+ *     _regions = None             # <<<<<<<<<<<<<<
+ * 
+ *     # statefull stuff
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___regions, Py_None) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 299; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":302
+ * 
+ *     # statefull stuff
+ *     _lineno = -1             # <<<<<<<<<<<<<<
+ *     _line = None
+ *     _lines = None
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___lineno, __pyx_int_neg_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 302; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":303
+ *     # statefull stuff
+ *     _lineno = -1
+ *     _line = None             # <<<<<<<<<<<<<<
+ *     _lines = None
+ * 
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___line, Py_None) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 303; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":304
+ *     _lineno = -1
+ *     _line = None
+ *     _lines = None             # <<<<<<<<<<<<<<
+ * 
+ *     def __init__(self, _copy=None, reference=None, regions=None, lines=None, leftalign=False):
+ */
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___lines, Py_None) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 304; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":306
+ *     _lines = None
+ * 
+ *     def __init__(self, _copy=None, reference=None, regions=None, lines=None, leftalign=False):             # <<<<<<<<<<<<<<
+ *         # make error identifiers accessible by name
+ *         for id in self._errors.keys(): self.__dict__[self._errors[id].split(':')[0]] = id
+ */
+  __pyx_t_3 = __Pyx_PyBool_FromLong(0); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 306; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 306; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":327
+ *         self._lines = lines
+ * 
+ *     def error(self,line,error,opt=None):             # <<<<<<<<<<<<<<
+ *         if error in self._ignored_errors: return
+ *         errorlabel, errorstring = self._errors[error].split(':')
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_error, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__error, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 327; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":336
+ *         raise ValueError(errorstring)
+ * 
+ *     def parse_format(self,line,format,filter=False):             # <<<<<<<<<<<<<<
+ *         if self._version == 40:
+ *             if not format.startswith('<'):
+ */
+  __pyx_t_3 = __Pyx_PyBool_FromLong(0); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 336; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_k_15 = __pyx_t_3;
+  __Pyx_GIVEREF(__pyx_t_3);
+  __pyx_t_3 = 0;
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse_format, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 336; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 336; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse_format, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 336; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":398
+ * 
+ * 
+ *     def format_format( self, fmt, filter=False ):             # <<<<<<<<<<<<<<
+ *         values = [('ID',fmt.id)]
+ *         if fmt.number != None and not filter:
+ */
+  __pyx_t_4 = __Pyx_PyBool_FromLong(0); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 398; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_k_32 = __pyx_t_4;
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+  __pyx_t_4 = 0;
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_format_format, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 398; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 398; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__format_format, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 398; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":418
+ *         return format
+ * 
+ *     def get_expected(self, format, formatdict, alt):             # <<<<<<<<<<<<<<
+ *         fmt = formatdict[format]
+ *         if fmt.numbertype == self.NT_UNKNOWN: return -1
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_get_expected, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 418; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 418; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__get_expected, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 418; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":429
+ * 
+ * 
+ *     def _add_definition(self, formatdict, key, data, line ):             # <<<<<<<<<<<<<<
+ *         if key in formatdict: return
+ *         self.error(line,self.ERROR_UNKNOWN_KEY,key)
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF__add_definition, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 429; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 429; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___add_definition, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 429; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ * 
+ *     # todo: trim trailing missing values
+ *     def format_formatdata( self, data, format, key=True, value=True, separator=":" ):             # <<<<<<<<<<<<<<
+ *         output, sdata = [], []
+ *         if type(data) == type([]): # for FORMAT field, make data with dummy values
+ */
+  __pyx_t_3 = __Pyx_PyBool_FromLong(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 446; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_k_36 = __pyx_t_3;
+  __Pyx_GIVEREF(__pyx_t_3);
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+  __pyx_t_3 = __Pyx_PyBool_FromLong(1); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 446; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_GIVEREF(__pyx_t_3);
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+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 446; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__format_formatdata, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 446; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":480
+ * 
+ * 
+ *     def enter_default_format(self):             # <<<<<<<<<<<<<<
+ *         for f in [FORMAT('GT',self.NT_NUMBER,1,'String','Genotype','.'),
+ *                   FORMAT('GQ',self.NT_NUMBER,1,'Integer','Genotype Quality',-1),
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_enter_default_format, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 480; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 480; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s_69, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 480; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":489
+ *                 self._format[f.id] = f
+ * 
+ *     def parse_header( self, line ):             # <<<<<<<<<<<<<<
+ *         assert line.startswith('##')
+ *         elts = line[2:].split('=')
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse_header, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 489; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 489; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse_header, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 489; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":518
+ * 
+ * 
+ *     def write_header( self, stream ):             # <<<<<<<<<<<<<<
+ *         stream.write("##fileformat=VCFv%s.%s\n" % (self._version // 10, self._version % 10))
+ *         for key,value in self._header: stream.write("##%s=%s\n" % (key,value))
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_write_header, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 518; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 518; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__write_header, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 518; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":525
+ * 
+ * 
+ *     def parse_heading( self, line ):             # <<<<<<<<<<<<<<
+ *         assert line.startswith('#')
+ *         assert not line.startswith('##')
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse_heading, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse_heading, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 525; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":553
+ *         self._sample2column = dict( [(y,x+9) for x,y in enumerate( self._samples ) ] )
+ * 
+ *     def write_heading( self, stream ):             # <<<<<<<<<<<<<<
+ *         stream.write("#" + "\t".join(self._required + self._samples) + "\n")
+ * 
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_write_heading, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 553; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 553; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__write_heading, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 553; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":556
+ *         stream.write("#" + "\t".join(self._required + self._samples) + "\n")
+ * 
+ *     def convertGT(self, GTstring):             # <<<<<<<<<<<<<<
+ *         if GTstring == ".": return ["."]
+ *         try:
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_convertGT, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 556; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 556; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__convertGT, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 556; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":569
+ * 
+ * 
+ *     def convertGTback(self, GTdata):             # <<<<<<<<<<<<<<
+ *         return ''.join(map(str,GTdata))
+ * 
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_convertGTback, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 569; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 569; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__convertGTback, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 569; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":572
+ *         return ''.join(map(str,GTdata))
+ * 
+ *     def parse_formatdata( self, key, value, formatdict, line ):             # <<<<<<<<<<<<<<
+ *         # To do: check that the right number of values is present
+ *         f = formatdict.get(key,None)
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse_formatdata, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 572; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 572; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse_formatdata, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 572; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":615
+ * 
+ * 
+ *     def inregion(self, chrom, pos):             # <<<<<<<<<<<<<<
+ *         if not self._regions: return True
+ *         for r in self._regions:
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_inregion, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 615; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 615; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__inregion, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 615; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":622
+ * 
+ * 
+ *     def parse_data( self, line, lineparse=False ):             # <<<<<<<<<<<<<<
+ *         cols = line.split('\t')
+ *         if len(cols) != len(self._samples)+9:
+ */
+  __pyx_t_3 = __Pyx_PyBool_FromLong(0); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 622; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_k_61 = __pyx_t_3;
+  __Pyx_GIVEREF(__pyx_t_3);
+  __pyx_t_3 = 0;
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse_data, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 622; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 622; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse_data, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 622; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":822
+ * 
+ * 
+ *     def write_data(self, stream, data):             # <<<<<<<<<<<<<<
+ *         required = ['chrom','pos','id','ref','alt','qual','filter','info','format'] + self._samples
+ *         for k in required:
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_write_data, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 822; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 822; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__write_data, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 822; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":851
+ *         stream.write( "\t".join(output) + "\n" )
+ * 
+ *     def _parse_header(self, stream):             # <<<<<<<<<<<<<<
+ *         self._lineno = 0
+ *         for line in stream:
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF__parse_header, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 851; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 851; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___parse_header, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 851; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":864
+ *         return line
+ * 
+ *     def _parse(self, line, stream):             # <<<<<<<<<<<<<<
+ *         if len(line.strip()) > 0:
+ *             d = self.parse_data( line.strip() )
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF__parse, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 864; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 864; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s___parse, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 864; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":880
+ *     ######################################################################################################
+ * 
+ *     def getsamples(self):             # <<<<<<<<<<<<<<
+ *         """ List of samples in VCF file """
+ *         return self._samples
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_getsamples, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 880; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 880; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__getsamples, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 880; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":884
+ *         return self._samples
+ * 
+ *     def setsamples(self,samples):             # <<<<<<<<<<<<<<
+ *         """ List of samples in VCF file """
+ *         self._samples = samples
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setsamples, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 884; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 884; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setsamples, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 884; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":888
+ *         self._samples = samples
+ * 
+ *     def getheader(self):             # <<<<<<<<<<<<<<
+ *         """ List of header key-value pairs (strings) """
+ *         return self._header
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_getheader, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 888; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 888; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__getheader, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 888; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":892
+ *         return self._header
+ * 
+ *     def setheader(self,header):             # <<<<<<<<<<<<<<
+ *         """ List of header key-value pairs (strings) """
+ *         self._header = header
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setheader, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 892; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 892; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setheader, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 892; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":896
+ *         self._header = header
+ * 
+ *     def getinfo(self):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ *         return self._info
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_getinfo, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 896; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 896; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__getinfo, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 896; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":900
+ *         return self._info
+ * 
+ *     def setinfo(self,info):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ *         self._info = info
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setinfo, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 900; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 900; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setinfo, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 900; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":904
+ *         self._info = info
+ * 
+ *     def getformat(self):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ *         return self._format
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_getformat, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 904; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 904; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__getformat, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 904; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":908
+ *         return self._format
+ * 
+ *     def setformat(self,format):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ *         self._format = format
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setformat, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 908; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 908; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setformat, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 908; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":912
+ *         self._format = format
+ * 
+ *     def getfilter(self):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ *         return self._filter
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_getfilter, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 912; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 912; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__getfilter, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 912; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":916
+ *         return self._filter
+ * 
+ *     def setfilter(self,filter):             # <<<<<<<<<<<<<<
+ *         """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ *         self._filter = filter
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setfilter, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 916; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 916; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setfilter, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 916; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":920
+ *         self._filter = filter
+ * 
+ *     def setversion(self, version):             # <<<<<<<<<<<<<<
+ *         if version != 33 and version != 40: raise ValueError("Can only handle v3.3 and v4.0 VCF files")
+ *         self._version = version
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setversion, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 920; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 920; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setversion, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 920; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":924
+ *         self._version = version
+ * 
+ *     def setregions(self, regions):             # <<<<<<<<<<<<<<
+ *         self._regions = regions
+ * 
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setregions, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 924; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 924; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setregions, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 924; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":927
+ *         self._regions = regions
+ * 
+ *     def setreference(self, ref):             # <<<<<<<<<<<<<<
+ *         """ Provide a reference sequence; a Python class supporting a fetch(chromosome, start, end) method, e.g. PySam.FastaFile """
+ *         self._reference = ref
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_setreference, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 927; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 927; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__setreference, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 927; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":931
+ *         self._reference = ref
+ * 
+ *     def ignoreerror(self, errorstring):             # <<<<<<<<<<<<<<
+ *         try:             self._ignored_errors.add(self.__dict__[errorstring])
+ *         except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_ignoreerror, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 931; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 931; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__ignoreerror, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 931; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":935
+ *         except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+ * 
+ *     def warnerror(self, errorstring):             # <<<<<<<<<<<<<<
+ *         try:             self._warn_errors.add(self.__dict__[errorstring])
+ *         except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_warnerror, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 935; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 935; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__warnerror, __pyx_t_4) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 935; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":939
+ *         except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+ * 
+ *     def parse(self, stream):             # <<<<<<<<<<<<<<
+ *         """ Parse a stream of VCF-formatted lines.  Initializes class instance and return generator """
+ *         last_line = self._parse_header(stream)
+ */
+  __pyx_t_4 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_parse, NULL); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 939; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __pyx_t_3 = PyMethod_New(__pyx_t_4, 0, __pyx_t_2); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 939; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
+  if (PyObject_SetAttr(__pyx_t_2, __pyx_n_s__parse, __pyx_t_3) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 939; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
+
+  /* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":946
+ *         return self._parse(last_line, stream)
+ * 
+ *     def write(self, stream, datagenerator):             # <<<<<<<<<<<<<<
+ *         """ Writes a VCF file to a stream, using a data generator (or list) """
+ *         self.write_header(stream)
+ */
+  __pyx_t_3 = PyCFunction_New(&__pyx_mdef_4cvcf_3VCF_write, NULL); if (unlikely(!__pyx_t_3)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_3);
+  __pyx_t_4 = PyMethod_New(__pyx_t_3, 0, __pyx_t_2); if (unlikely(!__pyx_t_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
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+ *         for data in datagenerator: self.write_data(stream,data)
+ * 
+ *     def writeheader(self, stream):             # <<<<<<<<<<<<<<
+ *         """ Writes a VCF header """
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+ */
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+  __Pyx_GOTREF(__pyx_t_4);
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+  __Pyx_GOTREF(__pyx_t_3);
+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ *         self.write_heading(stream)
+ * 
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+  __Pyx_GOTREF(__pyx_t_3);
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+  __Pyx_GOTREF(__pyx_t_4);
+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ * ###########################################################################################################
+ * 
+ *     def connect( self, filename ):             # <<<<<<<<<<<<<<
+ *         '''connect to tabix file.'''
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+  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
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+  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ *         self._parse_header(self.tabixfile.header)
+ * 
+ *     def fetch(self,             # <<<<<<<<<<<<<<
+ *               reference = None,
+ *               start = None,
+ */
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+  __Pyx_GOTREF(__pyx_t_4);
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+ * 
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+ * 
+ */
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+ * 
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+ *     "VCF", "VCFRecord", ]
+ * 
+ */
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__VCF));
+  __Pyx_INCREF(((PyObject *)__pyx_n_s__VCFRecord));
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+  __Pyx_GIVEREF(((PyObject *)__pyx_n_s__VCFRecord));
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+ */
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+  __Pyx_GOTREF(((PyObject *)__pyx_t_1));
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+ * cdef extern from "string.h":             # <<<<<<<<<<<<<<
+ *   ctypedef int size_t
+ *   void *memcpy(void *dst,void *src,size_t len)
+ */
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+        #endif
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+    int exact,
+    Py_ssize_t num_min,
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+    Py_ssize_t num_found)
+{
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+    const char *number, *more_or_less;
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+    }
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+    const char* function_name)
+{
+    PyObject *key = 0, *value = 0;
+    Py_ssize_t pos = 0;
+    PyObject*** name;
+    PyObject*** first_kw_arg = argnames + num_pos_args;
+
+    while (PyDict_Next(kwds, &pos, &key, &value)) {
+        name = first_kw_arg;
+        while (*name && (**name != key)) name++;
+        if (*name) {
+            values[name-argnames] = value;
+        } else {
+            #if PY_MAJOR_VERSION < 3
+            if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key))) {
+            #else
+            if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key))) {
+            #endif
+                goto invalid_keyword_type;
+            } else {
+                for (name = first_kw_arg; *name; name++) {
+                    #if PY_MAJOR_VERSION >= 3
+                    if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+                        PyUnicode_Compare(**name, key) == 0) break;
+                    #else
+                    if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+                        _PyString_Eq(**name, key)) break;
+                    #endif
+                }
+                if (*name) {
+                    values[name-argnames] = value;
+                } else {
+                    /* unexpected keyword found */
+                    for (name=argnames; name != first_kw_arg; name++) {
+                        if (**name == key) goto arg_passed_twice;
+                        #if PY_MAJOR_VERSION >= 3
+                        if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+                            PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
+                        #else
+                        if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+                            _PyString_Eq(**name, key)) goto arg_passed_twice;
+                        #endif
+                    }
+                    if (kwds2) {
+                        if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
+                    } else {
+                        goto invalid_keyword;
+                    }
+                }
+            }
+        }
+    }
+    return 0;
+arg_passed_twice:
+    __Pyx_RaiseDoubleKeywordsError(function_name, **name);
+    goto bad;
+invalid_keyword_type:
+    PyErr_Format(PyExc_TypeError,
+        "%s() keywords must be strings", function_name);
+    goto bad;
+invalid_keyword:
+    PyErr_Format(PyExc_TypeError,
+    #if PY_MAJOR_VERSION < 3
+        "%s() got an unexpected keyword argument '%s'",
+        function_name, PyString_AsString(key));
+    #else
+        "%s() got an unexpected keyword argument '%U'",
+        function_name, key);
+    #endif
+bad:
+    return -1;
+}
+
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb) {
+    PyObject *local_type, *local_value, *local_tb;
+    PyObject *tmp_type, *tmp_value, *tmp_tb;
+    PyThreadState *tstate = PyThreadState_GET();
+    local_type = tstate->curexc_type;
+    local_value = tstate->curexc_value;
+    local_tb = tstate->curexc_traceback;
+    tstate->curexc_type = 0;
+    tstate->curexc_value = 0;
+    tstate->curexc_traceback = 0;
+    PyErr_NormalizeException(&local_type, &local_value, &local_tb);
+    if (unlikely(tstate->curexc_type))
+        goto bad;
+    #if PY_MAJOR_VERSION >= 3
+    if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
+        goto bad;
+    #endif
+    *type = local_type;
+    *value = local_value;
+    *tb = local_tb;
+    Py_INCREF(local_type);
+    Py_INCREF(local_value);
+    Py_INCREF(local_tb);
+    tmp_type = tstate->exc_type;
+    tmp_value = tstate->exc_value;
+    tmp_tb = tstate->exc_traceback;
+    tstate->exc_type = local_type;
+    tstate->exc_value = local_value;
+    tstate->exc_traceback = local_tb;
+    /* Make sure tstate is in a consistent state when we XDECREF
+       these objects (XDECREF may run arbitrary code). */
+    Py_XDECREF(tmp_type);
+    Py_XDECREF(tmp_value);
+    Py_XDECREF(tmp_tb);
+    return 0;
+bad:
+    *type = 0;
+    *value = 0;
+    *tb = 0;
+    Py_XDECREF(local_type);
+    Py_XDECREF(local_value);
+    Py_XDECREF(local_tb);
+    return -1;
+}
+
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj) {
+    PyObject* float_value;
+    if (Py_TYPE(obj)->tp_as_number && Py_TYPE(obj)->tp_as_number->nb_float) {
+        return PyFloat_AsDouble(obj);
+    } else if (PyUnicode_CheckExact(obj) || PyBytes_CheckExact(obj)) {
+#if PY_MAJOR_VERSION >= 3
+        float_value = PyFloat_FromString(obj);
+#else
+        float_value = PyFloat_FromString(obj, 0);
+#endif
+    } else {
+        PyObject* args = PyTuple_New(1);
+        if (unlikely(!args)) goto bad;
+        PyTuple_SET_ITEM(args, 0, obj);
+        float_value = PyObject_Call((PyObject*)&PyFloat_Type, args, 0);
+        PyTuple_SET_ITEM(args, 0, 0);
+        Py_DECREF(args);
+    }
+    if (likely(float_value)) {
+        double value = PyFloat_AS_DOUBLE(float_value);
+        Py_DECREF(float_value);
+        return value;
+    }
+bad:
+    return (double)-1;
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
+    PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
+    PyErr_Format(PyExc_ValueError,
+        #if PY_VERSION_HEX < 0x02050000
+                 "need more than %d value%s to unpack", (int)index,
+        #else
+                 "need more than %zd value%s to unpack", index,
+        #endif
+                 (index == 1) ? "" : "s");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
+    PyErr_Format(PyExc_ValueError,
+        #if PY_VERSION_HEX < 0x02050000
+            "too many values to unpack (expected %d)", (int)expected);
+        #else
+            "too many values to unpack (expected %zd)", expected);
+        #endif
+}
+
+static PyObject *__Pyx_UnpackItem(PyObject *iter, Py_ssize_t index) {
+    PyObject *item;
+    if (!(item = PyIter_Next(iter))) {
+        if (!PyErr_Occurred()) {
+            __Pyx_RaiseNeedMoreValuesError(index);
+        }
+    }
+    return item;
+}
+
+static int __Pyx_EndUnpack(PyObject *iter, Py_ssize_t expected) {
+    PyObject *item;
+    if ((item = PyIter_Next(iter))) {
+        Py_DECREF(item);
+        __Pyx_RaiseTooManyValuesError(expected);
+        return -1;
+    }
+    else if (!PyErr_Occurred())
+        return 0;
+    else
+        return -1;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t a, Py_ssize_t b) {
+    Py_ssize_t q = a / b;
+    Py_ssize_t r = a - q*b;
+    q -= ((r != 0) & ((r ^ b) < 0));
+    return q;
+}
+
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
+    PyThreadState *tstate = PyThreadState_GET();
+    *type = tstate->exc_type;
+    *value = tstate->exc_value;
+    *tb = tstate->exc_traceback;
+    Py_XINCREF(*type);
+    Py_XINCREF(*value);
+    Py_XINCREF(*tb);
+}
+
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
+    PyObject *tmp_type, *tmp_value, *tmp_tb;
+    PyThreadState *tstate = PyThreadState_GET();
+    tmp_type = tstate->exc_type;
+    tmp_value = tstate->exc_value;
+    tmp_tb = tstate->exc_traceback;
+    tstate->exc_type = type;
+    tstate->exc_value = value;
+    tstate->exc_traceback = tb;
+    Py_XDECREF(tmp_type);
+    Py_XDECREF(tmp_value);
+    Py_XDECREF(tmp_tb);
+}
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
+    PyObject *py_import = 0;
+    PyObject *empty_list = 0;
+    PyObject *module = 0;
+    PyObject *global_dict = 0;
+    PyObject *empty_dict = 0;
+    PyObject *list;
+    py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
+    if (!py_import)
+        goto bad;
+    if (from_list)
+        list = from_list;
+    else {
+        empty_list = PyList_New(0);
+        if (!empty_list)
+            goto bad;
+        list = empty_list;
+    }
+    global_dict = PyModule_GetDict(__pyx_m);
+    if (!global_dict)
+        goto bad;
+    empty_dict = PyDict_New();
+    if (!empty_dict)
+        goto bad;
+    module = PyObject_CallFunctionObjArgs(py_import,
+        name, global_dict, empty_dict, list, NULL);
+bad:
+    Py_XDECREF(empty_list);
+    Py_XDECREF(py_import);
+    Py_XDECREF(empty_dict);
+    return module;
+}
+
+static PyObject *__Pyx_CreateClass(
+    PyObject *bases, PyObject *dict, PyObject *name, const char *modname)
+{
+    PyObject *py_modname;
+    PyObject *result = 0;
+
+    #if PY_MAJOR_VERSION < 3
+    py_modname = PyString_FromString(modname);
+    #else
+    py_modname = PyUnicode_FromString(modname);
+    #endif
+    if (!py_modname)
+        goto bad;
+    if (PyDict_SetItemString(dict, "__module__", py_modname) < 0)
+        goto bad;
+    #if PY_MAJOR_VERSION < 3
+    result = PyClass_New(bases, dict, name);
+    #else
+    result = PyObject_CallFunctionObjArgs((PyObject *)&PyType_Type, name, bases, dict, NULL);
+    #endif
+bad:
+    Py_XDECREF(py_modname);
+    return result;
+}
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
+    PyObject *tmp_type, *tmp_value, *tmp_tb;
+    PyThreadState *tstate = PyThreadState_GET();
+
+    tmp_type = tstate->curexc_type;
+    tmp_value = tstate->curexc_value;
+    tmp_tb = tstate->curexc_traceback;
+    tstate->curexc_type = type;
+    tstate->curexc_value = value;
+    tstate->curexc_traceback = tb;
+    Py_XDECREF(tmp_type);
+    Py_XDECREF(tmp_value);
+    Py_XDECREF(tmp_tb);
+}
+
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
+    PyThreadState *tstate = PyThreadState_GET();
+    *type = tstate->curexc_type;
+    *value = tstate->curexc_value;
+    *tb = tstate->curexc_traceback;
+
+    tstate->curexc_type = 0;
+    tstate->curexc_value = 0;
+    tstate->curexc_traceback = 0;
+}
+
+
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+    Py_XINCREF(type);
+    Py_XINCREF(value);
+    Py_XINCREF(tb);
+    /* First, check the traceback argument, replacing None with NULL. */
+    if (tb == Py_None) {
+        Py_DECREF(tb);
+        tb = 0;
+    }
+    else if (tb != NULL && !PyTraceBack_Check(tb)) {
+        PyErr_SetString(PyExc_TypeError,
+            "raise: arg 3 must be a traceback or None");
+        goto raise_error;
+    }
+    /* Next, replace a missing value with None */
+    if (value == NULL) {
+        value = Py_None;
+        Py_INCREF(value);
+    }
+    #if PY_VERSION_HEX < 0x02050000
+    if (!PyClass_Check(type))
+    #else
+    if (!PyType_Check(type))
+    #endif
+    {
+        /* Raising an instance.  The value should be a dummy. */
+        if (value != Py_None) {
+            PyErr_SetString(PyExc_TypeError,
+                "instance exception may not have a separate value");
+            goto raise_error;
+        }
+        /* Normalize to raise <class>, <instance> */
+        Py_DECREF(value);
+        value = type;
+        #if PY_VERSION_HEX < 0x02050000
+            if (PyInstance_Check(type)) {
+                type = (PyObject*) ((PyInstanceObject*)type)->in_class;
+                Py_INCREF(type);
+            }
+            else {
+                type = 0;
+                PyErr_SetString(PyExc_TypeError,
+                    "raise: exception must be an old-style class or instance");
+                goto raise_error;
+            }
+        #else
+            type = (PyObject*) Py_TYPE(type);
+            Py_INCREF(type);
+            if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+                PyErr_SetString(PyExc_TypeError,
+                    "raise: exception class must be a subclass of BaseException");
+                goto raise_error;
+            }
+        #endif
+    }
+
+    __Pyx_ErrRestore(type, value, tb);
+    return;
+raise_error:
+    Py_XDECREF(value);
+    Py_XDECREF(type);
+    Py_XDECREF(tb);
+    return;
+}
+
+#else /* Python 3+ */
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+    if (tb == Py_None) {
+        tb = 0;
+    } else if (tb && !PyTraceBack_Check(tb)) {
+        PyErr_SetString(PyExc_TypeError,
+            "raise: arg 3 must be a traceback or None");
+        goto bad;
+    }
+    if (value == Py_None)
+        value = 0;
+
+    if (PyExceptionInstance_Check(type)) {
+        if (value) {
+            PyErr_SetString(PyExc_TypeError,
+                "instance exception may not have a separate value");
+            goto bad;
+        }
+        value = type;
+        type = (PyObject*) Py_TYPE(value);
+    } else if (!PyExceptionClass_Check(type)) {
+        PyErr_SetString(PyExc_TypeError,
+            "raise: exception class must be a subclass of BaseException");
+        goto bad;
+    }
+
+    PyErr_SetObject(type, value);
+
+    if (tb) {
+        PyThreadState *tstate = PyThreadState_GET();
+        PyObject* tmp_tb = tstate->curexc_traceback;
+        if (tb != tmp_tb) {
+            Py_INCREF(tb);
+            tstate->curexc_traceback = tb;
+            Py_XDECREF(tmp_tb);
+        }
+    }
+
+bad:
+    return;
+}
+#endif
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t val) {
+    const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+    const int is_unsigned = const_zero < neg_one;
+    if ((sizeof(uint32_t) == sizeof(char))  ||
+        (sizeof(uint32_t) == sizeof(short))) {
+        return PyInt_FromLong((long)val);
+    } else if ((sizeof(uint32_t) == sizeof(int)) ||
+               (sizeof(uint32_t) == sizeof(long))) {
+        if (is_unsigned)
+            return PyLong_FromUnsignedLong((unsigned long)val);
+        else
+            return PyInt_FromLong((long)val);
+    } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+        if (is_unsigned)
+            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+        else
+            return PyLong_FromLongLong((PY_LONG_LONG)val);
+    } else {
+        int one = 1; int little = (int)*(unsigned char *)&one;
+        unsigned char *bytes = (unsigned char *)&val;
+        return _PyLong_FromByteArray(bytes, sizeof(uint32_t), 
+                                     little, !is_unsigned);
+    }
+}
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
+    const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(unsigned char) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(unsigned char)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to unsigned char" :
+                    "value too large to convert to unsigned char");
+            }
+            return (unsigned char)-1;
+        }
+        return (unsigned char)val;
+    }
+    return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
+    const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(unsigned short) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(unsigned short)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to unsigned short" :
+                    "value too large to convert to unsigned short");
+            }
+            return (unsigned short)-1;
+        }
+        return (unsigned short)val;
+    }
+    return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
+    const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(unsigned int) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(unsigned int)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to unsigned int" :
+                    "value too large to convert to unsigned int");
+            }
+            return (unsigned int)-1;
+        }
+        return (unsigned int)val;
+    }
+    return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
+    const char neg_one = (char)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(char) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(char)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to char" :
+                    "value too large to convert to char");
+            }
+            return (char)-1;
+        }
+        return (char)val;
+    }
+    return (char)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
+    const short neg_one = (short)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(short) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(short)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to short" :
+                    "value too large to convert to short");
+            }
+            return (short)-1;
+        }
+        return (short)val;
+    }
+    return (short)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
+    const int neg_one = (int)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(int) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(int)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to int" :
+                    "value too large to convert to int");
+            }
+            return (int)-1;
+        }
+        return (int)val;
+    }
+    return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
+    const signed char neg_one = (signed char)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(signed char) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(signed char)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to signed char" :
+                    "value too large to convert to signed char");
+            }
+            return (signed char)-1;
+        }
+        return (signed char)val;
+    }
+    return (signed char)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
+    const signed short neg_one = (signed short)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(signed short) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(signed short)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to signed short" :
+                    "value too large to convert to signed short");
+            }
+            return (signed short)-1;
+        }
+        return (signed short)val;
+    }
+    return (signed short)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
+    const signed int neg_one = (signed int)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(signed int) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(signed int)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to signed int" :
+                    "value too large to convert to signed int");
+            }
+            return (signed int)-1;
+        }
+        return (signed int)val;
+    }
+    return (signed int)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
+    const int neg_one = (int)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+    if (sizeof(int) < sizeof(long)) {
+        long val = __Pyx_PyInt_AsLong(x);
+        if (unlikely(val != (long)(int)val)) {
+            if (!unlikely(val == -1 && PyErr_Occurred())) {
+                PyErr_SetString(PyExc_OverflowError,
+                    (is_unsigned && unlikely(val < 0)) ?
+                    "can't convert negative value to int" :
+                    "value too large to convert to int");
+            }
+            return (int)-1;
+        }
+        return (int)val;
+    }
+    return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
+    const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to unsigned long");
+            return (unsigned long)-1;
+        }
+        return (unsigned long)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to unsigned long");
+                return (unsigned long)-1;
+            }
+            return PyLong_AsUnsignedLong(x);
+        } else {
+            return PyLong_AsLong(x);
+        }
+    } else {
+        unsigned long val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (unsigned long)-1;
+        val = __Pyx_PyInt_AsUnsignedLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
+    const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to unsigned PY_LONG_LONG");
+            return (unsigned PY_LONG_LONG)-1;
+        }
+        return (unsigned PY_LONG_LONG)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to unsigned PY_LONG_LONG");
+                return (unsigned PY_LONG_LONG)-1;
+            }
+            return PyLong_AsUnsignedLongLong(x);
+        } else {
+            return PyLong_AsLongLong(x);
+        }
+    } else {
+        unsigned PY_LONG_LONG val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (unsigned PY_LONG_LONG)-1;
+        val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
+    const long neg_one = (long)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to long");
+            return (long)-1;
+        }
+        return (long)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to long");
+                return (long)-1;
+            }
+            return PyLong_AsUnsignedLong(x);
+        } else {
+            return PyLong_AsLong(x);
+        }
+    } else {
+        long val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (long)-1;
+        val = __Pyx_PyInt_AsLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
+    const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to PY_LONG_LONG");
+            return (PY_LONG_LONG)-1;
+        }
+        return (PY_LONG_LONG)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to PY_LONG_LONG");
+                return (PY_LONG_LONG)-1;
+            }
+            return PyLong_AsUnsignedLongLong(x);
+        } else {
+            return PyLong_AsLongLong(x);
+        }
+    } else {
+        PY_LONG_LONG val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (PY_LONG_LONG)-1;
+        val = __Pyx_PyInt_AsLongLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
+    const signed long neg_one = (signed long)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to signed long");
+            return (signed long)-1;
+        }
+        return (signed long)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to signed long");
+                return (signed long)-1;
+            }
+            return PyLong_AsUnsignedLong(x);
+        } else {
+            return PyLong_AsLong(x);
+        }
+    } else {
+        signed long val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (signed long)-1;
+        val = __Pyx_PyInt_AsSignedLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
+    const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
+    const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+    if (likely(PyInt_Check(x))) {
+        long val = PyInt_AS_LONG(x);
+        if (is_unsigned && unlikely(val < 0)) {
+            PyErr_SetString(PyExc_OverflowError,
+                            "can't convert negative value to signed PY_LONG_LONG");
+            return (signed PY_LONG_LONG)-1;
+        }
+        return (signed PY_LONG_LONG)val;
+    } else
+#endif
+    if (likely(PyLong_Check(x))) {
+        if (is_unsigned) {
+            if (unlikely(Py_SIZE(x) < 0)) {
+                PyErr_SetString(PyExc_OverflowError,
+                                "can't convert negative value to signed PY_LONG_LONG");
+                return (signed PY_LONG_LONG)-1;
+            }
+            return PyLong_AsUnsignedLongLong(x);
+        } else {
+            return PyLong_AsLongLong(x);
+        }
+    } else {
+        signed PY_LONG_LONG val;
+        PyObject *tmp = __Pyx_PyNumber_Int(x);
+        if (!tmp) return (signed PY_LONG_LONG)-1;
+        val = __Pyx_PyInt_AsSignedLongLong(tmp);
+        Py_DECREF(tmp);
+        return val;
+    }
+}
+
+#ifndef __PYX_HAVE_RT_ImportType
+#define __PYX_HAVE_RT_ImportType
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
+    long size, int strict)
+{
+    PyObject *py_module = 0;
+    PyObject *result = 0;
+    PyObject *py_name = 0;
+    char warning[200];
+
+    py_module = __Pyx_ImportModule(module_name);
+    if (!py_module)
+        goto bad;
+    #if PY_MAJOR_VERSION < 3
+    py_name = PyString_FromString(class_name);
+    #else
+    py_name = PyUnicode_FromString(class_name);
+    #endif
+    if (!py_name)
+        goto bad;
+    result = PyObject_GetAttr(py_module, py_name);
+    Py_DECREF(py_name);
+    py_name = 0;
+    Py_DECREF(py_module);
+    py_module = 0;
+    if (!result)
+        goto bad;
+    if (!PyType_Check(result)) {
+        PyErr_Format(PyExc_TypeError, 
+            "%s.%s is not a type object",
+            module_name, class_name);
+        goto bad;
+    }
+    if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
+        PyOS_snprintf(warning, sizeof(warning), 
+            "%s.%s size changed, may indicate binary incompatibility",
+            module_name, class_name);
+        #if PY_VERSION_HEX < 0x02050000
+        PyErr_Warn(NULL, warning);
+        #else
+        PyErr_WarnEx(NULL, warning, 0);
+        #endif
+    }
+    else if (((PyTypeObject *)result)->tp_basicsize != size) {
+        PyErr_Format(PyExc_ValueError, 
+            "%s.%s has the wrong size, try recompiling",
+            module_name, class_name);
+        goto bad;
+    }
+    return (PyTypeObject *)result;
+bad:
+    Py_XDECREF(py_module);
+    Py_XDECREF(result);
+    return 0;
+}
+#endif
+
+#ifndef __PYX_HAVE_RT_ImportModule
+#define __PYX_HAVE_RT_ImportModule
+static PyObject *__Pyx_ImportModule(const char *name) {
+    PyObject *py_name = 0;
+    PyObject *py_module = 0;
+
+    #if PY_MAJOR_VERSION < 3
+    py_name = PyString_FromString(name);
+    #else
+    py_name = PyUnicode_FromString(name);
+    #endif
+    if (!py_name)
+        goto bad;
+    py_module = PyImport_Import(py_name);
+    Py_DECREF(py_name);
+    return py_module;
+bad:
+    Py_XDECREF(py_name);
+    return 0;
+}
+#endif
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr) {
+    PyObject *ob = PyMapping_GetItemString(dict, (char *)"__pyx_vtable__");
+    if (!ob)
+        goto bad;
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+    *(void **)vtabptr = PyCapsule_GetPointer(ob, 0);
+#else
+    *(void **)vtabptr = PyCObject_AsVoidPtr(ob);
+#endif
+    if (!*(void **)vtabptr)
+        goto bad;
+    Py_DECREF(ob);
+    return 0;
+bad:
+    Py_XDECREF(ob);
+    return -1;
+}
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+    PyObject *ob = PyCapsule_New(vtable, 0, 0);
+#else
+    PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
+#endif
+    if (!ob)
+        goto bad;
+    if (PyDict_SetItemString(dict, "__pyx_vtable__", ob) < 0)
+        goto bad;
+    Py_DECREF(ob);
+    return 0;
+bad:
+    Py_XDECREF(ob);
+    return -1;
+}
+
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+
+static void __Pyx_AddTraceback(const char *funcname) {
+    PyObject *py_srcfile = 0;
+    PyObject *py_funcname = 0;
+    PyObject *py_globals = 0;
+    PyCodeObject *py_code = 0;
+    PyFrameObject *py_frame = 0;
+
+    #if PY_MAJOR_VERSION < 3
+    py_srcfile = PyString_FromString(__pyx_filename);
+    #else
+    py_srcfile = PyUnicode_FromString(__pyx_filename);
+    #endif
+    if (!py_srcfile) goto bad;
+    if (__pyx_clineno) {
+        #if PY_MAJOR_VERSION < 3
+        py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+        #else
+        py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+        #endif
+    }
+    else {
+        #if PY_MAJOR_VERSION < 3
+        py_funcname = PyString_FromString(funcname);
+        #else
+        py_funcname = PyUnicode_FromString(funcname);
+        #endif
+    }
+    if (!py_funcname) goto bad;
+    py_globals = PyModule_GetDict(__pyx_m);
+    if (!py_globals) goto bad;
+    py_code = PyCode_New(
+        0,            /*int argcount,*/
+        #if PY_MAJOR_VERSION >= 3
+        0,            /*int kwonlyargcount,*/
+        #endif
+        0,            /*int nlocals,*/
+        0,            /*int stacksize,*/
+        0,            /*int flags,*/
+        __pyx_empty_bytes, /*PyObject *code,*/
+        __pyx_empty_tuple,  /*PyObject *consts,*/
+        __pyx_empty_tuple,  /*PyObject *names,*/
+        __pyx_empty_tuple,  /*PyObject *varnames,*/
+        __pyx_empty_tuple,  /*PyObject *freevars,*/
+        __pyx_empty_tuple,  /*PyObject *cellvars,*/
+        py_srcfile,   /*PyObject *filename,*/
+        py_funcname,  /*PyObject *name,*/
+        __pyx_lineno,   /*int firstlineno,*/
+        __pyx_empty_bytes  /*PyObject *lnotab*/
+    );
+    if (!py_code) goto bad;
+    py_frame = PyFrame_New(
+        PyThreadState_GET(), /*PyThreadState *tstate,*/
+        py_code,             /*PyCodeObject *code,*/
+        py_globals,          /*PyObject *globals,*/
+        0                    /*PyObject *locals*/
+    );
+    if (!py_frame) goto bad;
+    py_frame->f_lineno = __pyx_lineno;
+    PyTraceBack_Here(py_frame);
+bad:
+    Py_XDECREF(py_srcfile);
+    Py_XDECREF(py_funcname);
+    Py_XDECREF(py_code);
+    Py_XDECREF(py_frame);
+}
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+    while (t->p) {
+        #if PY_MAJOR_VERSION < 3
+        if (t->is_unicode) {
+            *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+        } else if (t->intern) {
+            *t->p = PyString_InternFromString(t->s);
+        } else {
+            *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+        }
+        #else  /* Python 3+ has unicode identifiers */
+        if (t->is_unicode | t->is_str) {
+            if (t->intern) {
+                *t->p = PyUnicode_InternFromString(t->s);
+            } else if (t->encoding) {
+                *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
+            } else {
+                *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
+            }
+        } else {
+            *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
+        }
+        #endif
+        if (!*t->p)
+            return -1;
+        ++t;
+    }
+    return 0;
+}
+
+/* Type Conversion Functions */
+
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+   int is_true = x == Py_True;
+   if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+   else return PyObject_IsTrue(x);
+}
+
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
+  PyNumberMethods *m;
+  const char *name = NULL;
+  PyObject *res = NULL;
+#if PY_VERSION_HEX < 0x03000000
+  if (PyInt_Check(x) || PyLong_Check(x))
+#else
+  if (PyLong_Check(x))
+#endif
+    return Py_INCREF(x), x;
+  m = Py_TYPE(x)->tp_as_number;
+#if PY_VERSION_HEX < 0x03000000
+  if (m && m->nb_int) {
+    name = "int";
+    res = PyNumber_Int(x);
+  }
+  else if (m && m->nb_long) {
+    name = "long";
+    res = PyNumber_Long(x);
+  }
+#else
+  if (m && m->nb_int) {
+    name = "int";
+    res = PyNumber_Long(x);
+  }
+#endif
+  if (res) {
+#if PY_VERSION_HEX < 0x03000000
+    if (!PyInt_Check(res) && !PyLong_Check(res)) {
+#else
+    if (!PyLong_Check(res)) {
+#endif
+      PyErr_Format(PyExc_TypeError,
+                   "__%s__ returned non-%s (type %.200s)",
+                   name, name, Py_TYPE(res)->tp_name);
+      Py_DECREF(res);
+      return NULL;
+    }
+  }
+  else if (!PyErr_Occurred()) {
+    PyErr_SetString(PyExc_TypeError,
+                    "an integer is required");
+  }
+  return res;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+  Py_ssize_t ival;
+  PyObject* x = PyNumber_Index(b);
+  if (!x) return -1;
+  ival = PyInt_AsSsize_t(x);
+  Py_DECREF(x);
+  return ival;
+}
+
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+#if PY_VERSION_HEX < 0x02050000
+   if (ival <= LONG_MAX)
+       return PyInt_FromLong((long)ival);
+   else {
+       unsigned char *bytes = (unsigned char *) &ival;
+       int one = 1; int little = (int)*(unsigned char*)&one;
+       return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
+   }
+#else
+   return PyInt_FromSize_t(ival);
+#endif
+}
+
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
+   unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
+   if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
+       return (size_t)-1;
+   } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
+       PyErr_SetString(PyExc_OverflowError,
+                       "value too large to convert to size_t");
+       return (size_t)-1;
+   }
+   return (size_t)val;
+}
+
+
+#endif /* Py_PYTHON_H */