include INSTALL
include KNOWN_BUGS
include THANKS
+include ez_setup.py
include pysam/csamtools.pxd
+include pysam/csamtools.pyx
+include pysam/csamtools.c
include pysam/ctabix.pxd
+include pysam/ctabix.c
+include pysam/ctabix.pyx
+include pysam/TabProxies.c
+include pysam/TabProxies.pyx
+include pysam/TabProxies.pxd
+include pysam/cvcf.pyx
+include pysam/cvcf.pxd
+include pysam/cvcf.c
include pysam/pysam_util.h
include samtools/*.h
+include samtools/*/*.h
include tabix/*.h
# pysam tests
include tests/ex6.sam
include tests/ex7.sam
include tests/ex8.sam
+include tests/ex9_fail.bam
+include tests/ex9_nofail.bam
+include tests/ex10.sam
include tests/example.py
include tests/pysam_test.py
include tests/segfault_tests.py
-Metadata-Version: 1.0
+Metadata-Version: 1.1
Name: pysam
-Version: 0.3.1
+Version: 0.5
Summary: pysam
Home-page: http://code.google.com/p/pysam/
Author: Andreas Heger
Platform: ALL
+Requires: cython (>=0.12)
--- /dev/null
+#!python
+"""Bootstrap setuptools installation
+
+If you want to use setuptools in your package's setup.py, just include this
+file in the same directory with it, and add this to the top of your setup.py::
+
+ from ez_setup import use_setuptools
+ use_setuptools()
+
+If you want to require a specific version of setuptools, set a download
+mirror, or use an alternate download directory, you can do so by supplying
+the appropriate options to ``use_setuptools()``.
+
+This file can also be run as a script to install or upgrade setuptools.
+"""
+import sys
+DEFAULT_VERSION = "0.6c11"
+DEFAULT_URL = "http://pypi.python.org/packages/%s/s/setuptools/" % sys.version[:3]
+
+md5_data = {
+ 'setuptools-0.6b1-py2.3.egg': '8822caf901250d848b996b7f25c6e6ca',
+ 'setuptools-0.6b1-py2.4.egg': 'b79a8a403e4502fbb85ee3f1941735cb',
+ 'setuptools-0.6b2-py2.3.egg': '5657759d8a6d8fc44070a9d07272d99b',
+ 'setuptools-0.6b2-py2.4.egg': '4996a8d169d2be661fa32a6e52e4f82a',
+ 'setuptools-0.6b3-py2.3.egg': 'bb31c0fc7399a63579975cad9f5a0618',
+ 'setuptools-0.6b3-py2.4.egg': '38a8c6b3d6ecd22247f179f7da669fac',
+ 'setuptools-0.6b4-py2.3.egg': '62045a24ed4e1ebc77fe039aa4e6f7e5',
+ 'setuptools-0.6b4-py2.4.egg': '4cb2a185d228dacffb2d17f103b3b1c4',
+ 'setuptools-0.6c1-py2.3.egg': 'b3f2b5539d65cb7f74ad79127f1a908c',
+ 'setuptools-0.6c1-py2.4.egg': 'b45adeda0667d2d2ffe14009364f2a4b',
+ 'setuptools-0.6c10-py2.3.egg': 'ce1e2ab5d3a0256456d9fc13800a7090',
+ 'setuptools-0.6c10-py2.4.egg': '57d6d9d6e9b80772c59a53a8433a5dd4',
+ 'setuptools-0.6c10-py2.5.egg': 'de46ac8b1c97c895572e5e8596aeb8c7',
+ 'setuptools-0.6c10-py2.6.egg': '58ea40aef06da02ce641495523a0b7f5',
+ 'setuptools-0.6c11-py2.3.egg': '2baeac6e13d414a9d28e7ba5b5a596de',
+ 'setuptools-0.6c11-py2.4.egg': 'bd639f9b0eac4c42497034dec2ec0c2b',
+ 'setuptools-0.6c11-py2.5.egg': '64c94f3bf7a72a13ec83e0b24f2749b2',
+ 'setuptools-0.6c11-py2.6.egg': 'bfa92100bd772d5a213eedd356d64086',
+ 'setuptools-0.6c2-py2.3.egg': 'f0064bf6aa2b7d0f3ba0b43f20817c27',
+ 'setuptools-0.6c2-py2.4.egg': '616192eec35f47e8ea16cd6a122b7277',
+ 'setuptools-0.6c3-py2.3.egg': 'f181fa125dfe85a259c9cd6f1d7b78fa',
+ 'setuptools-0.6c3-py2.4.egg': 'e0ed74682c998bfb73bf803a50e7b71e',
+ 'setuptools-0.6c3-py2.5.egg': 'abef16fdd61955514841c7c6bd98965e',
+ 'setuptools-0.6c4-py2.3.egg': 'b0b9131acab32022bfac7f44c5d7971f',
+ 'setuptools-0.6c4-py2.4.egg': '2a1f9656d4fbf3c97bf946c0a124e6e2',
+ 'setuptools-0.6c4-py2.5.egg': '8f5a052e32cdb9c72bcf4b5526f28afc',
+ 'setuptools-0.6c5-py2.3.egg': 'ee9fd80965da04f2f3e6b3576e9d8167',
+ 'setuptools-0.6c5-py2.4.egg': 'afe2adf1c01701ee841761f5bcd8aa64',
+ 'setuptools-0.6c5-py2.5.egg': 'a8d3f61494ccaa8714dfed37bccd3d5d',
+ 'setuptools-0.6c6-py2.3.egg': '35686b78116a668847237b69d549ec20',
+ 'setuptools-0.6c6-py2.4.egg': '3c56af57be3225019260a644430065ab',
+ 'setuptools-0.6c6-py2.5.egg': 'b2f8a7520709a5b34f80946de5f02f53',
+ 'setuptools-0.6c7-py2.3.egg': '209fdf9adc3a615e5115b725658e13e2',
+ 'setuptools-0.6c7-py2.4.egg': '5a8f954807d46a0fb67cf1f26c55a82e',
+ 'setuptools-0.6c7-py2.5.egg': '45d2ad28f9750e7434111fde831e8372',
+ 'setuptools-0.6c8-py2.3.egg': '50759d29b349db8cfd807ba8303f1902',
+ 'setuptools-0.6c8-py2.4.egg': 'cba38d74f7d483c06e9daa6070cce6de',
+ 'setuptools-0.6c8-py2.5.egg': '1721747ee329dc150590a58b3e1ac95b',
+ 'setuptools-0.6c9-py2.3.egg': 'a83c4020414807b496e4cfbe08507c03',
+ 'setuptools-0.6c9-py2.4.egg': '260a2be2e5388d66bdaee06abec6342a',
+ 'setuptools-0.6c9-py2.5.egg': 'fe67c3e5a17b12c0e7c541b7ea43a8e6',
+ 'setuptools-0.6c9-py2.6.egg': 'ca37b1ff16fa2ede6e19383e7b59245a',
+}
+
+import sys, os
+try: from hashlib import md5
+except ImportError: from md5 import md5
+
+def _validate_md5(egg_name, data):
+ if egg_name in md5_data:
+ digest = md5(data).hexdigest()
+ if digest != md5_data[egg_name]:
+ print >>sys.stderr, (
+ "md5 validation of %s failed! (Possible download problem?)"
+ % egg_name
+ )
+ sys.exit(2)
+ return data
+
+def use_setuptools(
+ version=DEFAULT_VERSION, download_base=DEFAULT_URL, to_dir=os.curdir,
+ download_delay=15
+):
+ """Automatically find/download setuptools and make it available on sys.path
+
+ `version` should be a valid setuptools version number that is available
+ as an egg for download under the `download_base` URL (which should end with
+ a '/'). `to_dir` is the directory where setuptools will be downloaded, if
+ it is not already available. If `download_delay` is specified, it should
+ be the number of seconds that will be paused before initiating a download,
+ should one be required. If an older version of setuptools is installed,
+ this routine will print a message to ``sys.stderr`` and raise SystemExit in
+ an attempt to abort the calling script.
+ """
+ was_imported = 'pkg_resources' in sys.modules or 'setuptools' in sys.modules
+ def do_download():
+ egg = download_setuptools(version, download_base, to_dir, download_delay)
+ sys.path.insert(0, egg)
+ import setuptools; setuptools.bootstrap_install_from = egg
+ try:
+ import pkg_resources
+ except ImportError:
+ return do_download()
+ try:
+ pkg_resources.require("setuptools>="+version); return
+ except pkg_resources.VersionConflict, e:
+ if was_imported:
+ print >>sys.stderr, (
+ "The required version of setuptools (>=%s) is not available, and\n"
+ "can't be installed while this script is running. Please install\n"
+ " a more recent version first, using 'easy_install -U setuptools'."
+ "\n\n(Currently using %r)"
+ ) % (version, e.args[0])
+ sys.exit(2)
+ else:
+ del pkg_resources, sys.modules['pkg_resources'] # reload ok
+ return do_download()
+ except pkg_resources.DistributionNotFound:
+ return do_download()
+
+def download_setuptools(
+ version=DEFAULT_VERSION, download_base=DEFAULT_URL, to_dir=os.curdir,
+ delay = 15
+):
+ """Download setuptools from a specified location and return its filename
+
+ `version` should be a valid setuptools version number that is available
+ as an egg for download under the `download_base` URL (which should end
+ with a '/'). `to_dir` is the directory where the egg will be downloaded.
+ `delay` is the number of seconds to pause before an actual download attempt.
+ """
+ import urllib2, shutil
+ egg_name = "setuptools-%s-py%s.egg" % (version,sys.version[:3])
+ url = download_base + egg_name
+ saveto = os.path.join(to_dir, egg_name)
+ src = dst = None
+ if not os.path.exists(saveto): # Avoid repeated downloads
+ try:
+ from distutils import log
+ if delay:
+ log.warn("""
+---------------------------------------------------------------------------
+This script requires setuptools version %s to run (even to display
+help). I will attempt to download it for you (from
+%s), but
+you may need to enable firewall access for this script first.
+I will start the download in %d seconds.
+
+(Note: if this machine does not have network access, please obtain the file
+
+ %s
+
+and place it in this directory before rerunning this script.)
+---------------------------------------------------------------------------""",
+ version, download_base, delay, url
+ ); from time import sleep; sleep(delay)
+ log.warn("Downloading %s", url)
+ src = urllib2.urlopen(url)
+ # Read/write all in one block, so we don't create a corrupt file
+ # if the download is interrupted.
+ data = _validate_md5(egg_name, src.read())
+ dst = open(saveto,"wb"); dst.write(data)
+ finally:
+ if src: src.close()
+ if dst: dst.close()
+ return os.path.realpath(saveto)
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+def main(argv, version=DEFAULT_VERSION):
+ """Install or upgrade setuptools and EasyInstall"""
+ try:
+ import setuptools
+ except ImportError:
+ egg = None
+ try:
+ egg = download_setuptools(version, delay=0)
+ sys.path.insert(0,egg)
+ from setuptools.command.easy_install import main
+ return main(list(argv)+[egg]) # we're done here
+ finally:
+ if egg and os.path.exists(egg):
+ os.unlink(egg)
+ else:
+ if setuptools.__version__ == '0.0.1':
+ print >>sys.stderr, (
+ "You have an obsolete version of setuptools installed. Please\n"
+ "remove it from your system entirely before rerunning this script."
+ )
+ sys.exit(2)
+
+ req = "setuptools>="+version
+ import pkg_resources
+ try:
+ pkg_resources.require(req)
+ except pkg_resources.VersionConflict:
+ try:
+ from setuptools.command.easy_install import main
+ except ImportError:
+ from easy_install import main
+ main(list(argv)+[download_setuptools(delay=0)])
+ sys.exit(0) # try to force an exit
+ else:
+ if argv:
+ from setuptools.command.easy_install import main
+ main(argv)
+ else:
+ print "Setuptools version",version,"or greater has been installed."
+ print '(Run "ez_setup.py -U setuptools" to reinstall or upgrade.)'
+
+def update_md5(filenames):
+ """Update our built-in md5 registry"""
+
+ import re
+
+ for name in filenames:
+ base = os.path.basename(name)
+ f = open(name,'rb')
+ md5_data[base] = md5(f.read()).hexdigest()
+ f.close()
+
+ data = [" %r: %r,\n" % it for it in md5_data.items()]
+ data.sort()
+ repl = "".join(data)
+
+ import inspect
+ srcfile = inspect.getsourcefile(sys.modules[__name__])
+ f = open(srcfile, 'rb'); src = f.read(); f.close()
+
+ match = re.search("\nmd5_data = {\n([^}]+)}", src)
+ if not match:
+ print >>sys.stderr, "Internal error!"
+ sys.exit(2)
+
+ src = src[:match.start(1)] + repl + src[match.end(1):]
+ f = open(srcfile,'w')
+ f.write(src)
+ f.close()
+
+
+if __name__=='__main__':
+ if len(sys.argv)>2 and sys.argv[1]=='--md5update':
+ update_md5(sys.argv[2:])
+ else:
+ main(sys.argv[1:])
+
+
+
+
+
+
--- /dev/null
+Metadata-Version: 1.1
+Name: pysam
+Version: 0.5
+Summary: pysam
+Home-page: http://code.google.com/p/pysam/
+Author: Andreas Heger
+Author-email: andreas.heger@gmail.com
+License: MIT
+Description:
+
+ pysam
+ *****
+
+
+Platform: ALL
+Requires: cython (>=0.12)
--- /dev/null
+COPYING
+INSTALL
+KNOWN_BUGS
+MANIFEST.in
+THANKS
+ez_setup.py
+setup.cfg
+setup.py
+pysam/Pileup.py
+pysam/TabProxies.c
+pysam/TabProxies.pxd
+pysam/TabProxies.pyx
+pysam/VCF.py
+pysam/__init__.py
+pysam/csamtools.c
+pysam/csamtools.pxd
+pysam/csamtools.pyx
+pysam/ctabix.c
+pysam/ctabix.pxd
+pysam/ctabix.pyx
+pysam/cvcf.c
+pysam/cvcf.pxd
+pysam/cvcf.pyx
+pysam/namedtuple.py
+pysam/pysam_util.c
+pysam/pysam_util.h
+pysam/tabix_util.c
+pysam/version.py
+pysam.egg-info/PKG-INFO
+pysam.egg-info/SOURCES.txt
+pysam.egg-info/dependency_links.txt
+pysam.egg-info/not-zip-safe
+pysam.egg-info/requires.txt
+pysam.egg-info/top_level.txt
+samtools/bam.c.pysam.c
+samtools/bam.h
+samtools/bam2bcf.c.pysam.c
+samtools/bam2bcf.h
+samtools/bam2bcf_indel.c.pysam.c
+samtools/bam2depth.c.pysam.c
+samtools/bam_aux.c.pysam.c
+samtools/bam_cat.c.pysam.c
+samtools/bam_color.c.pysam.c
+samtools/bam_endian.h
+samtools/bam_import.c.pysam.c
+samtools/bam_index.c.pysam.c
+samtools/bam_lpileup.c.pysam.c
+samtools/bam_maqcns.c.pysam.c
+samtools/bam_maqcns.h
+samtools/bam_mate.c.pysam.c
+samtools/bam_md.c.pysam.c
+samtools/bam_pileup.c.pysam.c
+samtools/bam_plcmd.c.pysam.c
+samtools/bam_rmdup.c.pysam.c
+samtools/bam_rmdupse.c.pysam.c
+samtools/bam_sort.c.pysam.c
+samtools/bam_stat.c.pysam.c
+samtools/bam_tview.c.pysam.c
+samtools/bedidx.c.pysam.c
+samtools/bgzf.c.pysam.c
+samtools/bgzf.h
+samtools/cut_target.c.pysam.c
+samtools/errmod.c.pysam.c
+samtools/errmod.h
+samtools/faidx.c.pysam.c
+samtools/faidx.h
+samtools/glf.c.pysam.c
+samtools/glf.h
+samtools/kaln.c.pysam.c
+samtools/kaln.h
+samtools/khash.h
+samtools/klist.h
+samtools/knetfile.c.pysam.c
+samtools/knetfile.h
+samtools/kprobaln.c.pysam.c
+samtools/kprobaln.h
+samtools/kseq.h
+samtools/ksort.h
+samtools/kstring.c.pysam.c
+samtools/kstring.h
+samtools/msvc_compat.h
+samtools/phase.c.pysam.c
+samtools/pysam.h
+samtools/razf.c.pysam.c
+samtools/razf.h
+samtools/sam.c.pysam.c
+samtools/sam.h
+samtools/sam_header.c.pysam.c
+samtools/sam_header.h
+samtools/sam_view.c.pysam.c
+samtools/sample.c.pysam.c
+samtools/sample.h
+samtools/bcftools/bcf.c.pysam.c
+samtools/bcftools/bcf.h
+samtools/bcftools/bcf2qcall.c.pysam.c
+samtools/bcftools/bcfutils.c.pysam.c
+samtools/bcftools/call1.c.pysam.c
+samtools/bcftools/em.c.pysam.c
+samtools/bcftools/fet.c.pysam.c
+samtools/bcftools/index.c.pysam.c
+samtools/bcftools/kfunc.c.pysam.c
+samtools/bcftools/kmin.c.pysam.c
+samtools/bcftools/kmin.h
+samtools/bcftools/prob1.c.pysam.c
+samtools/bcftools/prob1.h
+samtools/bcftools/vcf.c.pysam.c
+samtools/misc/md5.c.pysam.c
+samtools/misc/md5.h
+samtools/win32/xcurses.h
+samtools/win32/zconf.h
+samtools/win32/zlib.h
+tabix/bam_endian.h
+tabix/bedidx.c.pysam.c
+tabix/bgzf.c.pysam.c
+tabix/bgzf.h
+tabix/bgzip.c.pysam.c
+tabix/index.c.pysam.c
+tabix/khash.h
+tabix/knetfile.c.pysam.c
+tabix/knetfile.h
+tabix/kseq.h
+tabix/ksort.h
+tabix/kstring.c.pysam.c
+tabix/kstring.h
+tabix/msvc_compat.h
+tabix/pysam.h
+tabix/tabix.h
+tests/00README.txt
+tests/Makefile
+tests/ex1.fa
+tests/ex1.sam.gz
+tests/ex10.sam
+tests/ex3.sam
+tests/ex4.sam
+tests/ex5.sam
+tests/ex6.sam
+tests/ex7.sam
+tests/ex8.sam
+tests/ex9_fail.bam
+tests/ex9_nofail.bam
+tests/example.gtf.gz
+tests/example.gtf.gz.tbi
+tests/example.py
+tests/pysam_test.py
+tests/segfault_tests.py
+tests/tabix_test.py
\ No newline at end of file
--- /dev/null
+cython>=0.12.1
\ No newline at end of file
--- /dev/null
+pysam/namedtuple
+ctabix
+pysam/Pileup
+csamtools
+cvcf
+TabProxies
+pysam/version
+pysam/__init__
PileupSubstitution = collections.namedtuple( "PileupSubstitution",
" ".join( (\
"chromosome",
- "position",
+ "pos",
"reference_base",
- "consensus_base",
+ "genotype",
"consensus_quality",
"snp_quality",
- "rms_mapping_quality",
+ "mapping_quality",
"coverage",
"read_bases",
"base_qualities" ) ) )
PileupIndel = collections.namedtuple( "PileupIndel",
" ".join( (\
"chromosome",
- "position",
+ "pos",
"reference_base",
"genotype",
"consensus_quality",
"snp_quality",
- "rms_mapping_quality",
+ "mapping_quality",
"coverage",
- "first_allelle",
+ "first_allele",
"second_allele",
"reads_first",
"reads_second",
yield PileupSubstitution( *[x(y) for x,y in zip(conv_subst,d) ] )
except TypeError:
raise pysam.SamtoolsError( "parsing error in line: `%s`" % line)
+
+ENCODE_GENOTYPE = {
+ 'A': 'A', 'C': 'C', 'G': 'G', 'T': 'T',
+ 'AA': 'A', 'CC': 'C', 'GG': 'G', 'TT': 'T', 'UU': 'U',
+ 'AG': 'r', 'GA': 'R',
+ 'CT': 'y', 'TC': 'Y',
+ 'AC': 'm', 'CA': 'M',
+ 'GT': 'k', 'TG': 'K',
+ 'CG': 's', 'GC': 'S',
+ 'AT': 'w', 'TA': 'W',
+ }
+
+DECODE_GENOTYPE = {
+ 'A': 'AA',
+ 'C': 'CC',
+ 'G': 'GG',
+ 'T': 'TT',
+ 'r': 'AG', 'R': 'AG',
+ 'y': 'CT', 'Y': 'CT',
+ 'm': 'AC', 'M': 'AC',
+ 'k': 'GT', 'K': 'GT',
+ 's': 'CG', 'S': 'CG',
+ 'w': 'AT', 'W': 'AT',
+ }
+
+##------------------------------------------------------------
+def encodeGenotype( code ):
+ '''encode genotypes like GG, GA into a one-letter code.
+ The returned code is lower case if code[0] < code[1], otherwise
+ it is uppercase.
+ '''
+ return ENCODE_GENOTYPE[ code.upper() ]
+
+def decodeGenotype( code ):
+ '''decode single letter genotypes like m, M into two letters.
+ This is the reverse operation to :meth:`encodeGenotype`.
+ '''
+ return DECODE_GENOTYPE[ code ]
+
+def translateIndelGenotypeFromVCF( vcf_genotypes, ref ):
+ '''translate indel from vcf to pileup format.'''
+
+ # indels
+ def getPrefix( s1, s2 ):
+ '''get common prefix of strings s1 and s2.'''
+ n = min( len( s1), len( s2 ) )
+ for x in range( n ):
+ if s1[x] != s2[x]: return s1[:x]
+ return s1[:n]
+
+ def getSuffix( s1, s2 ):
+ '''get common sufix of strings s1 and s2.'''
+ n = min( len( s1), len( s2 ) )
+ if s1[-1] != s2[-1]: return ""
+ for x in range( -2, -n - 1, -1 ):
+ if s1[x] != s2[x]: return s1[x+1:]
+ return s1[-n:]
+
+ def getGenotype( variant, ref ):
+
+ if variant == ref: return "*", 0
+
+ if len(ref) > len(variant):
+ # is a deletion
+ if ref.startswith(variant):
+ return "-%s" % ref[len(variant):], len(variant) - 1
+ elif ref.endswith( variant ):
+ return "-%s" % ref[:-len(variant)], -1
+ else:
+ prefix = getPrefix( ref, variant )
+ suffix = getSuffix( ref, variant )
+ shared = len(prefix) + len(suffix) - len(variant)
+ # print "-", prefix, suffix, ref, variant, shared, len(prefix), len(suffix), len(ref)
+ if shared < 0:
+ raise ValueError()
+ return "-%s" % ref[len(prefix):-(len(suffix)-shared)], len(prefix) - 1
+
+ elif len(ref) < len(variant):
+ # is an insertion
+ if variant.startswith(ref):
+ return "+%s" % variant[len(ref):], len(ref) - 1
+ elif variant.endswith(ref):
+ return "+%s" % variant[:len(ref)], 0
+ else:
+ prefix = getPrefix( ref, variant )
+ suffix = getSuffix( ref, variant )
+ shared = len(prefix) + len(suffix) - len(ref)
+ if shared < 0:
+ raise ValueError()
+
+ return "+%s" % variant[len(prefix):-(len(suffix)-shared)], len(prefix)
+ else:
+ assert 0, "snp?"
+
+ # in pileup, the position refers to the base
+ # after the coordinate, hence subtract 1
+ #pos -= 1
+
+ genotypes, offsets = [], []
+ is_error = True
+
+ for variant in vcf_genotypes:
+ try:
+ g, offset = getGenotype( variant, ref )
+ except ValueError:
+ break
+
+ genotypes.append( g )
+ if g != "*": offsets.append( offset )
+
+ else:
+ is_error = False
+
+ if is_error:
+ raise ValueError()
+
+ assert len(set(offsets )) == 1, "multiple offsets for indel"
+ offset = offsets[0]
+
+ genotypes = "/".join( genotypes )
+ return genotypes, offset
+
+def vcf2pileup( vcf, sample ):
+ '''convert vcf record to pileup record.'''
+
+ chromosome = vcf.contig
+ pos = vcf.pos
+ reference = vcf.ref
+ allelles = [reference] + vcf.alt
+
+ data = vcf[sample]
+
+ # get genotype
+ genotypes = data["GT"]
+ if len(genotypes) > 1:
+ raise ValueError( "only single genotype per position, %s" % (str(vcf)))
+
+ genotypes = genotypes[0]
+
+ # not a variant
+ if genotypes[0] == ".": return None
+
+ genotypes = [ allelles[int(x)] for x in genotypes if x != "/" ]
+
+ # snp_quality is "genotype quality"
+ snp_quality = consensus_quality = data.get( "GQ", [0])[0]
+ mapping_quality = vcf.info.get( "MQ", [0])[0]
+ coverage = data.get( "DP", 0)
+
+ if len(reference) > 1 or max([len(x) for x in vcf.alt] ) > 1:
+ # indel
+ genotype, offset = translateIndelGenotypeFromVCF( genotypes, reference )
+
+ return PileupIndel( chromosome,
+ pos + offset,
+ "*",
+ genotype,
+ consensus_quality,
+ snp_quality,
+ mapping_quality,
+ coverage,
+ genotype,
+ "<" * len(genotype),
+ 0,
+ 0,
+ 0 )
+
+ else:
+
+ genotype = encodeGenotype( "".join(genotypes) )
+
+
+ read_bases = ""
+ base_qualities = ""
+
+ return PileupSubstitution( chromosome, pos, reference,
+ genotype,
+ consensus_quality,
+ snp_quality,
+ mapping_quality,
+ coverage, read_bases, base_qualities )
+
+
+def iterate_from_vcf( infile, sample ):
+ '''iterate over a vcf-formatted file.
+
+ *infile* can be any iterator over a lines.
+
+ The function yields named tuples of the type :class:`pysam.Pileup.PileupSubstitution`
+ or :class:`pysam.Pileup.PileupIndel`.
+
+ Positions without a snp will be skipped.
+
+ This method is wasteful and written to support same
+ legacy code that expects samtools pileup output.
+
+ Better use the vcf parser directly.
+
+ '''
+
+
+ vcf = pysam.VCF()
+ vcf.connect( infile )
+
+ if sample not in vcf.getsamples():
+ raise KeyErorr( "sample %s not vcf file" )
+
+ for row in vcf.fetch():
+ result = vcf2pileup( row, sample )
+ if result: yield result
+
--- /dev/null
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+ #define __stdcall
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+ #define PY_LONG_LONG LONG_LONG
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+ #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
+ #define PyDict_Contains(d,o) PySequence_Contains(d,o)
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+#if PY_VERSION_HEX < 0x02050000
+ typedef int Py_ssize_t;
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+ #define PyBytes_AsString PyString_AsString
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+ #define PyBytes_Size PyString_Size
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+ #define PyBytes_GET_SIZE PyString_GET_SIZE
+ #define PyBytes_Repr PyString_Repr
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+ #define PySet_Check(obj) PyObject_TypeCheck(obj, &PySet_Type)
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+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_TrueDivide(x,y)
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+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_Divide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceDivide(x,y)
+#endif
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+#if PY_MAJOR_VERSION >= 3
+ #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
+#endif
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+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),((char *)(n)))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
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+#else
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),(n))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),(n))
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+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_NAMESTR(n) ((char *)(n))
+ #define __Pyx_DOCSTR(n) ((char *)(n))
+#else
+ #define __Pyx_NAMESTR(n) (n)
+ #define __Pyx_DOCSTR(n) (n)
+#endif
+
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+
+#if defined(WIN32) || defined(MS_WINDOWS)
+#define _USE_MATH_DEFINES
+#endif
+#include <math.h>
+#define __PYX_HAVE_API__TabProxies
+#include "stdlib.h"
+#include "string.h"
+#include "stdint.h"
+#include "stdio.h"
+#include "pythread.h"
+
+/* inline attribute */
+#ifndef CYTHON_INLINE
+ #if defined(__GNUC__)
+ #define CYTHON_INLINE __inline__
+ #elif defined(_MSC_VER)
+ #define CYTHON_INLINE __inline
+ #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+ #define CYTHON_INLINE inline
+ #else
+ #define CYTHON_INLINE
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+
+/* unused attribute */
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+# if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+# elif defined(__ICC) || defined(__INTEL_COMPILER)
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
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+#endif
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+typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
+
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+/* Type Conversion Predeclarations */
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+#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
+#define __Pyx_PyBytes_AsUString(s) ((unsigned char*) PyBytes_AsString(s))
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+
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+/* Test for GCC > 2.95 */
+#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95))
+#define likely(x) __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* __GNUC__ > 2 ... */
+#define likely(x) (x)
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+#endif /* __GNUC__ > 2 ... */
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+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+
+static PyObject *__pyx_m;
+static PyObject *__pyx_b;
+static PyObject *__pyx_empty_tuple;
+static PyObject *__pyx_empty_bytes;
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+
+static const char *__pyx_f[] = {
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+ PyObject_HEAD
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtab;
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+ char **fields;
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+ int index;
+ int nbytes;
+ int offset;
+ int is_modified;
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+struct __pyx_obj_10TabProxies_NamedTupleProxy {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+};
+
+/* "pysam/TabProxies.pxd":91
+ * cdef update( self, char * buffer, size_t nbytes )
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+struct __pyx_obj_10TabProxies_VCFProxy {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+ char *contig;
+ uint32_t pos;
+};
+
+/* "pysam/TabProxies.pxd":60
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+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+ char *contig;
+ char *source;
+ char *feature;
+ uint32_t start;
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+/* "/ifs/devel/pysam/pysam/pysam/TabProxies.pyx":231
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+static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[], PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args, const char* function_name); /*proto*/
+
+static CYTHON_INLINE long __Pyx_NegateNonNeg(long b) { return unlikely(b < 0) ? b : !b; }
+static CYTHON_INLINE PyObject* __Pyx_PyBoolOrNull_FromLong(long b) {
+ return unlikely(b < 0) ? NULL : __Pyx_PyBool_FromLong(b);
+}
+
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
+ PyObject *r;
+ if (!j) return NULL;
+ r = PyObject_GetItem(o, j);
+ Py_DECREF(j);
+ return r;
+}
+
+
+#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_List_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ PyObject *r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Tuple_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ PyObject *r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+
+#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
+ r = PySequence_GetItem(o, i);
+ }
+ else {
+ r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+ }
+ return r;
+}
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj); /* proto */
+
+#define __Pyx_PyObject_AsDouble(obj) \
+ ((likely(PyFloat_CheckExact(obj))) ? \
+ PyFloat_AS_DOUBLE(obj) : __Pyx__PyObject_AsDouble(obj))
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
+
+static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
+static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t);
+
+static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject *);
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
+
+static void __Pyx_WriteUnraisable(const char *name); /*proto*/
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable); /*proto*/
+
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict); /*proto*/
+
+static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
+
+static void __Pyx_AddTraceback(const char *funcname); /*proto*/
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
+/* Module declarations from cpython.version */
+
+/* Module declarations from cpython.ref */
+
+/* Module declarations from cpython.exc */
+
+/* Module declarations from cpython.module */
+
+/* Module declarations from cpython.mem */
+
+/* Module declarations from cpython.tuple */
+
+/* Module declarations from cpython.list */
+
+/* Module declarations from libc.stdio */
+
+/* Module declarations from cpython.object */
+
+/* Module declarations from cpython.sequence */
+
+/* Module declarations from cpython.mapping */
+
+/* Module declarations from cpython.iterator */
+
+/* Module declarations from cpython.type */
+
+/* Module declarations from cpython.number */
+
+/* Module declarations from cpython.int */
+
+/* Module declarations from __builtin__ */
+
+/* Module declarations from cpython.bool */
+
+static PyTypeObject *__pyx_ptype_7cpython_4bool_bool = 0;
+/* Module declarations from cpython.long */
+
+/* Module declarations from cpython.float */
+
+/* Module declarations from cpython.complex */
+
+/* Module declarations from cpython.string */
+
+/* Module declarations from cpython.unicode */
+
+/* Module declarations from cpython.dict */
+
+/* Module declarations from cpython.instance */
+
+/* Module declarations from cpython.function */
+
+/* Module declarations from cpython.method */
+
+/* Module declarations from cpython.weakref */
+
+/* Module declarations from cpython.getargs */
+
+/* Module declarations from cpython.pythread */
+
+/* Module declarations from cpython.cobject */
+
+/* Module declarations from cpython.oldbuffer */
+
+/* Module declarations from cpython.set */
+
+/* Module declarations from cpython.buffer */
+
+/* Module declarations from cpython.bytes */
+
+/* Module declarations from cpython.pycapsule */
+
+/* Module declarations from cpython */
+
+/* Module declarations from TabProxies */
+
+static PyTypeObject *__pyx_ptype_10TabProxies_TupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_GTFProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_NamedTupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_BedProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_VCFProxy = 0;
+static char *__pyx_f_10TabProxies_nextItem(char *); /*proto*/
+static char *__pyx_f_10TabProxies_StrOrEmpty(char *); /*proto*/
+static int __pyx_f_10TabProxies_isNew(char *, char *, size_t); /*proto*/
+#define __Pyx_MODULE_NAME "TabProxies"
+int __pyx_module_is_main_TabProxies = 0;
+
+/* Implementation of TabProxies */
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_IndexError;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_xrange;
+static PyObject *__pyx_builtin_TypeError;
+static PyObject *__pyx_builtin_AttributeError;
+static PyObject *__pyx_builtin_KeyError;
+static char __pyx_k_1[] = "malformatted entry at %s";
+static char __pyx_k_2[] = "";
+static char __pyx_k_3[] = "out of memory";
+static char __pyx_k_4[] = "incomplete line at %s";
+static char __pyx_k_5[] = "row too large - more than %i fields";
+static char __pyx_k_6[] = "list index out of range";
+static char __pyx_k_7[] = "\t";
+static char __pyx_k_8[] = ".";
+static char __pyx_k_9[] = "\"%s\"";
+static char __pyx_k_10[] = ";";
+static char __pyx_k_11[] = " ";
+static char __pyx_k_12[] = "\"";
+static char __pyx_k_13[] = "%s \"%s\"";
+static char __pyx_k_14[] = "%s %s";
+static char __pyx_k_15[] = "; ";
+static char __pyx_k_16[] = "'GTFProxy' has no attribute '%s'";
+static char __pyx_k_17[] = "field %s not set";
+static char __pyx_k_18[] = "bed format requires at least three columns";
+static char __pyx_k_19[] = "contig of feature.";
+static char __pyx_k_20[] = "feature name.";
+static char __pyx_k_21[] = "feature source.";
+static char __pyx_k_22[] = "feature start (in 0-based open/closed coordinates).";
+static char __pyx_k_23[] = "feature end (in 0-based open/closed coordinates).";
+static char __pyx_k_24[] = "feature score.";
+static char __pyx_k_25[] = "feature strand.";
+static char __pyx_k_26[] = "feature frame.";
+static char __pyx_k_27[] = "feature attributes (as a string).";
+static char __pyx_k_28[] = "TupleProxy._setindex (line 154)";
+static char __pyx_k_29[] = "TupleProxy.__setitem__ (line 177)";
+static char __pyx_k_30[] = "TupleProxy.__next__ (line 192)";
+static char __pyx_k_31[] = "TupleProxy.__str__ (line 202)";
+static char __pyx_k_32[] = "toDot (line 219)";
+static char __pyx_k_33[] = "quote (line 224)";
+static char __pyx_k_34[] = "GTFProxy.asDict (line 350)";
+static char __pyx_k_35[] = "GTFProxy.fromDict (line 385)";
+static char __pyx_k_36[] = "GTFProxy.invert (line 430)";
+static char __pyx_k_37[] = "GTFProxy.keys (line 441)";
+static char __pyx_k_38[] = "GTFProxy.__getattr__ (line 449)";
+static char __pyx_k_39[] = "GTFProxy.setAttribute (line 482)";
+static char __pyx_k_40[] = "NamedTupleProxy.__setattr__ (line 492)";
+static char __pyx_k_41[] = "BedProxy.__setattr__ (line 564)";
+static char __pyx_k_42[] = "VCFProxy.__setattr__ (line 608)";
+static char __pyx_k__id[] = "id";
+static char __pyx_k__alt[] = "alt";
+static char __pyx_k__end[] = "end";
+static char __pyx_k__pos[] = "pos";
+static char __pyx_k__ref[] = "ref";
+static char __pyx_k__data[] = "data";
+static char __pyx_k__info[] = "info";
+static char __pyx_k__join[] = "join";
+static char __pyx_k__keys[] = "keys";
+static char __pyx_k__name[] = "name";
+static char __pyx_k__qual[] = "qual";
+static char __pyx_k__frame[] = "frame";
+static char __pyx_k__index[] = "index";
+static char __pyx_k__items[] = "items";
+static char __pyx_k__quote[] = "quote";
+static char __pyx_k__range[] = "range";
+static char __pyx_k__score[] = "score";
+static char __pyx_k__split[] = "split";
+static char __pyx_k__start[] = "start";
+static char __pyx_k__strip[] = "strip";
+static char __pyx_k__toDot[] = "toDot";
+static char __pyx_k__types[] = "types";
+static char __pyx_k__value[] = "value";
+static char __pyx_k__asDict[] = "asDict";
+static char __pyx_k__contig[] = "contig";
+static char __pyx_k__fields[] = "fields";
+static char __pyx_k__filter[] = "filter";
+static char __pyx_k__format[] = "format";
+static char __pyx_k__invert[] = "invert";
+static char __pyx_k__nbytes[] = "nbytes";
+static char __pyx_k__offset[] = "offset";
+static char __pyx_k__source[] = "source";
+static char __pyx_k__strand[] = "strand";
+static char __pyx_k__update[] = "update";
+static char __pyx_k__xrange[] = "xrange";
+static char __pyx_k____str__[] = "__str__";
+static char __pyx_k__feature[] = "feature";
+static char __pyx_k__itemRGB[] = "itemRGB";
+static char __pyx_k__nfields[] = "nfields";
+static char __pyx_k__BedProxy[] = "BedProxy";
+static char __pyx_k__GTFProxy[] = "GTFProxy";
+static char __pyx_k__KeyError[] = "KeyError";
+static char __pyx_k__VCFProxy[] = "VCFProxy";
+static char __pyx_k____main__[] = "__main__";
+static char __pyx_k____next__[] = "__next__";
+static char __pyx_k____test__[] = "__test__";
+static char __pyx_k__fromDict[] = "fromDict";
+static char __pyx_k__thickEnd[] = "thickEnd";
+static char __pyx_k__TypeError[] = "TypeError";
+static char __pyx_k___setindex[] = "_setindex";
+static char __pyx_k__bedfields[] = "bedfields";
+static char __pyx_k__IndexError[] = "IndexError";
+static char __pyx_k__StringType[] = "StringType";
+static char __pyx_k__TupleProxy[] = "TupleProxy";
+static char __pyx_k__ValueError[] = "ValueError";
+static char __pyx_k__attributes[] = "attributes";
+static char __pyx_k__blockCount[] = "blockCount";
+static char __pyx_k__blockSizes[] = "blockSizes";
+static char __pyx_k__thickStart[] = "thickStart";
+static char __pyx_k__StringTypes[] = "StringTypes";
+static char __pyx_k____getattr__[] = "__getattr__";
+static char __pyx_k____setattr__[] = "__setattr__";
+static char __pyx_k____setitem__[] = "__setitem__";
+static char __pyx_k__blockStarts[] = "blockStarts";
+static char __pyx_k__is_modified[] = "is_modified";
+static char __pyx_k__getMaxFields[] = "getMaxFields";
+static char __pyx_k__setAttribute[] = "setAttribute";
+static char __pyx_k__StopIteration[] = "StopIteration";
+static char __pyx_k__map_key2field[] = "map_key2field";
+static char __pyx_k__AttributeError[] = "AttributeError";
+static char __pyx_k__NamedTupleProxy[] = "NamedTupleProxy";
+static char __pyx_k__hasOwnAttributes[] = "hasOwnAttributes";
+static PyObject *__pyx_kp_s_1;
+static PyObject *__pyx_kp_s_10;
+static PyObject *__pyx_kp_s_11;
+static PyObject *__pyx_kp_s_12;
+static PyObject *__pyx_kp_s_13;
+static PyObject *__pyx_kp_s_14;
+static PyObject *__pyx_kp_s_15;
+static PyObject *__pyx_kp_s_16;
+static PyObject *__pyx_kp_s_17;
+static PyObject *__pyx_kp_s_18;
+static PyObject *__pyx_kp_s_2;
+static PyObject *__pyx_kp_u_28;
+static PyObject *__pyx_kp_u_29;
+static PyObject *__pyx_kp_s_3;
+static PyObject *__pyx_kp_u_30;
+static PyObject *__pyx_kp_u_31;
+static PyObject *__pyx_kp_u_32;
+static PyObject *__pyx_kp_u_33;
+static PyObject *__pyx_kp_u_34;
+static PyObject *__pyx_kp_u_35;
+static PyObject *__pyx_kp_u_36;
+static PyObject *__pyx_kp_u_37;
+static PyObject *__pyx_kp_u_38;
+static PyObject *__pyx_kp_u_39;
+static PyObject *__pyx_kp_s_4;
+static PyObject *__pyx_kp_u_40;
+static PyObject *__pyx_kp_u_41;
+static PyObject *__pyx_kp_u_42;
+static PyObject *__pyx_kp_s_5;
+static PyObject *__pyx_kp_s_6;
+static PyObject *__pyx_kp_s_7;
+static PyObject *__pyx_kp_s_8;
+static PyObject *__pyx_kp_s_9;
+static PyObject *__pyx_n_s__AttributeError;
+static PyObject *__pyx_n_s__BedProxy;
+static PyObject *__pyx_n_s__GTFProxy;
+static PyObject *__pyx_n_s__IndexError;
+static PyObject *__pyx_n_s__KeyError;
+static PyObject *__pyx_n_s__NamedTupleProxy;
+static PyObject *__pyx_n_s__StopIteration;
+static PyObject *__pyx_n_s__StringType;
+static PyObject *__pyx_n_s__StringTypes;
+static PyObject *__pyx_n_s__TupleProxy;
+static PyObject *__pyx_n_s__TypeError;
+static PyObject *__pyx_n_s__VCFProxy;
+static PyObject *__pyx_n_s__ValueError;
+static PyObject *__pyx_n_s____getattr__;
+static PyObject *__pyx_n_s____main__;
+static PyObject *__pyx_n_s____next__;
+static PyObject *__pyx_n_s____setattr__;
+static PyObject *__pyx_n_s____setitem__;
+static PyObject *__pyx_n_s____str__;
+static PyObject *__pyx_n_s____test__;
+static PyObject *__pyx_n_s___setindex;
+static PyObject *__pyx_n_s__alt;
+static PyObject *__pyx_n_s__asDict;
+static PyObject *__pyx_n_s__attributes;
+static PyObject *__pyx_n_s__bedfields;
+static PyObject *__pyx_n_s__blockCount;
+static PyObject *__pyx_n_s__blockSizes;
+static PyObject *__pyx_n_s__blockStarts;
+static PyObject *__pyx_n_s__contig;
+static PyObject *__pyx_n_s__data;
+static PyObject *__pyx_n_s__end;
+static PyObject *__pyx_n_s__feature;
+static PyObject *__pyx_n_s__fields;
+static PyObject *__pyx_n_s__filter;
+static PyObject *__pyx_n_s__format;
+static PyObject *__pyx_n_s__frame;
+static PyObject *__pyx_n_s__fromDict;
+static PyObject *__pyx_n_s__getMaxFields;
+static PyObject *__pyx_n_s__hasOwnAttributes;
+static PyObject *__pyx_n_s__id;
+static PyObject *__pyx_n_s__index;
+static PyObject *__pyx_n_s__info;
+static PyObject *__pyx_n_s__invert;
+static PyObject *__pyx_n_s__is_modified;
+static PyObject *__pyx_n_s__itemRGB;
+static PyObject *__pyx_n_s__items;
+static PyObject *__pyx_n_s__join;
+static PyObject *__pyx_n_s__keys;
+static PyObject *__pyx_n_s__map_key2field;
+static PyObject *__pyx_n_s__name;
+static PyObject *__pyx_n_s__nbytes;
+static PyObject *__pyx_n_s__nfields;
+static PyObject *__pyx_n_s__offset;
+static PyObject *__pyx_n_s__pos;
+static PyObject *__pyx_n_s__qual;
+static PyObject *__pyx_n_s__quote;
+static PyObject *__pyx_n_s__range;
+static PyObject *__pyx_n_s__ref;
+static PyObject *__pyx_n_s__score;
+static PyObject *__pyx_n_s__setAttribute;
+static PyObject *__pyx_n_s__source;
+static PyObject *__pyx_n_s__split;
+static PyObject *__pyx_n_s__start;
+static PyObject *__pyx_n_s__strand;
+static PyObject *__pyx_n_s__strip;
+static PyObject *__pyx_n_s__thickEnd;
+static PyObject *__pyx_n_s__thickStart;
+static PyObject *__pyx_n_s__toDot;
+static PyObject *__pyx_n_s__types;
+static PyObject *__pyx_n_s__update;
+static PyObject *__pyx_n_s__value;
+static PyObject *__pyx_n_s__xrange;
+static PyObject *__pyx_int_0;
+static PyObject *__pyx_int_1;
+static PyObject *__pyx_int_2;
+static PyObject *__pyx_int_3;
+static PyObject *__pyx_int_4;
+static PyObject *__pyx_int_5;
+static PyObject *__pyx_int_6;
+static PyObject *__pyx_int_7;
+static PyObject *__pyx_int_8;
+static PyObject *__pyx_int_9;
+static PyObject *__pyx_int_10;
+static PyObject *__pyx_int_11;
+
+/* "/ifs/devel/pysam/pysam/pysam/TabProxies.pyx":4
+ * from cpython cimport PyString_FromStringAndSize, PyString_AsString, PyString_AS_STRING
+ *
+ * cdef char * nextItem( char * buffer ): # <<<<<<<<<<<<<<
+ * cdef char * pos
+ * pos = strchr( buffer, '\t' )
+ */
+
+static char *__pyx_f_10TabProxies_nextItem(char *__pyx_v_buffer) {
+ char *__pyx_v_pos;
+ char *__pyx_r;
+ int __pyx_t_1;
+ PyObject *__pyx_t_2 = NULL;
+ PyObject *__pyx_t_3 = NULL;
+ __Pyx_RefNannySetupContext("nextItem");
+
+ /* "/ifs/devel/pysam/pysam/pysam/TabProxies.pyx":6
+ * cdef char * nextItem( char * buffer ):
+ * cdef char * pos
+ * pos = strchr( buffer, '\t' ) # <<<<<<<<<<<<<<
+ * if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
+ * pos[0] = '\0'
+ */
+ __pyx_v_pos = strchr(__pyx_v_buffer, '\t');
+
+ /* "/ifs/devel/pysam/pysam/pysam/TabProxies.pyx":7
+ * cdef char * pos
+ * pos = strchr( buffer, '\t' )
+ * if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer ) # <<<<<<<<<<<<<<
+ * pos[0] = '\0'
+ * pos += 1
+ */
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+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_TupleProxy = {
+ __pyx_pf_10TabProxies_10TupleProxy___len__, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ __pyx_sq_item_10TabProxies_TupleProxy, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_TupleProxy = {
+ __pyx_pf_10TabProxies_10TupleProxy___len__, /*mp_length*/
+ __pyx_pf_10TabProxies_10TupleProxy___getitem__, /*mp_subscript*/
+ __pyx_mp_ass_subscript_10TabProxies_TupleProxy, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_TupleProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_10TabProxies_TupleProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("TabProxies.TupleProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_10TabProxies_TupleProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_10TabProxies_TupleProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_TupleProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_TupleProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_TupleProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ __pyx_pf_10TabProxies_10TupleProxy___str__, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_TupleProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("Proxy class for access to parsed row as a tuple.\n\n This class represents a table row for fast read-access.\n\n Access to individual fields is via the [] operator.\n \n Only read-only access is implemented.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_10TabProxies_10TupleProxy___iter__, /*tp_iter*/
+ __pyx_pf_10TabProxies_10TupleProxy___next__, /*tp_iternext*/
+ __pyx_methods_10TabProxies_TupleProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_10TabProxies_TupleProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_10TabProxies_GTFProxy __pyx_vtable_10TabProxies_GTFProxy;
+
+static PyObject *__pyx_tp_new_10TabProxies_GTFProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_10TabProxies_GTFProxy *p;
+ PyObject *o = __pyx_tp_new_10TabProxies_TupleProxy(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_10TabProxies_GTFProxy *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_10TabProxies_GTFProxy;
+ if (__pyx_pf_10TabProxies_8GTFProxy___cinit__(o, __pyx_empty_tuple, NULL) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_10TabProxies_GTFProxy(PyObject *o) {
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_10TabProxies_8GTFProxy___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ __pyx_tp_dealloc_10TabProxies_TupleProxy(o);
+}
+static PyObject *__pyx_sq_item_10TabProxies_GTFProxy(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ PyObject *x = PyInt_FromSsize_t(i); if(!x) return 0;
+ r = Py_TYPE(o)->tp_as_mapping->mp_subscript(o, x);
+ Py_DECREF(x);
+ return r;
+}
+
+static PyObject *__pyx_tp_getattro_10TabProxies_GTFProxy(PyObject *o, PyObject *n) {
+ PyObject *v = PyObject_GenericGetAttr(o, n);
+ if (!v && PyErr_ExceptionMatches(PyExc_AttributeError)) {
+ PyErr_Clear();
+ v = __pyx_pf_10TabProxies_8GTFProxy___getattr__(o, n);
+ }
+ return v;
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_contig(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6contig___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_contig(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6contig___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_feature(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_7feature___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_feature(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_7feature___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_source(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6source___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_source(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6source___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_start(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5start___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_start(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5start___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_end(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_3end___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_end(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_3end___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_score(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5score___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_score(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5score___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_strand(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6strand___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_strand(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_6strand___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_frame(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5frame___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_frame(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_5frame___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_10TabProxies_8GTFProxy_attributes(PyObject *o, void *x) {
+ return __pyx_pf_10TabProxies_8GTFProxy_10attributes___get__(o);
+}
+
+static int __pyx_setprop_10TabProxies_8GTFProxy_attributes(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8GTFProxy_10attributes___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyMethodDef __pyx_methods_10TabProxies_GTFProxy[] = {
+ {__Pyx_NAMESTR("asDict"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy_asDict, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy_asDict)},
+ {__Pyx_NAMESTR("fromDict"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy_fromDict, METH_O, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy_fromDict)},
+ {__Pyx_NAMESTR("invert"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy_invert, METH_O, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy_invert)},
+ {__Pyx_NAMESTR("keys"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy_keys, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy_keys)},
+ {__Pyx_NAMESTR("__getattr__"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy___getattr__, METH_O|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy___getattr__)},
+ {__Pyx_NAMESTR("setAttribute"), (PyCFunction)__pyx_pf_10TabProxies_8GTFProxy_setAttribute, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_10TabProxies_8GTFProxy_setAttribute)},
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_10TabProxies_GTFProxy[] = {
+ {(char *)"contig", __pyx_getprop_10TabProxies_8GTFProxy_contig, __pyx_setprop_10TabProxies_8GTFProxy_contig, __Pyx_DOCSTR(__pyx_k_19), 0},
+ {(char *)"feature", __pyx_getprop_10TabProxies_8GTFProxy_feature, __pyx_setprop_10TabProxies_8GTFProxy_feature, __Pyx_DOCSTR(__pyx_k_20), 0},
+ {(char *)"source", __pyx_getprop_10TabProxies_8GTFProxy_source, __pyx_setprop_10TabProxies_8GTFProxy_source, __Pyx_DOCSTR(__pyx_k_21), 0},
+ {(char *)"start", __pyx_getprop_10TabProxies_8GTFProxy_start, __pyx_setprop_10TabProxies_8GTFProxy_start, __Pyx_DOCSTR(__pyx_k_22), 0},
+ {(char *)"end", __pyx_getprop_10TabProxies_8GTFProxy_end, __pyx_setprop_10TabProxies_8GTFProxy_end, __Pyx_DOCSTR(__pyx_k_23), 0},
+ {(char *)"score", __pyx_getprop_10TabProxies_8GTFProxy_score, __pyx_setprop_10TabProxies_8GTFProxy_score, __Pyx_DOCSTR(__pyx_k_24), 0},
+ {(char *)"strand", __pyx_getprop_10TabProxies_8GTFProxy_strand, __pyx_setprop_10TabProxies_8GTFProxy_strand, __Pyx_DOCSTR(__pyx_k_25), 0},
+ {(char *)"frame", __pyx_getprop_10TabProxies_8GTFProxy_frame, __pyx_setprop_10TabProxies_8GTFProxy_frame, __Pyx_DOCSTR(__pyx_k_26), 0},
+ {(char *)"attributes", __pyx_getprop_10TabProxies_8GTFProxy_attributes, __pyx_setprop_10TabProxies_8GTFProxy_attributes, __Pyx_DOCSTR(__pyx_k_27), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_GTFProxy = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_GTFProxy = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ __pyx_sq_item_10TabProxies_GTFProxy, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_GTFProxy = {
+ 0, /*mp_length*/
+ __pyx_pf_10TabProxies_8GTFProxy___getitem__, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_GTFProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_10TabProxies_GTFProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("TabProxies.GTFProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_10TabProxies_GTFProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_10TabProxies_GTFProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_GTFProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_GTFProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_GTFProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ __pyx_pf_10TabProxies_8GTFProxy___str__, /*tp_str*/
+ __pyx_tp_getattro_10TabProxies_GTFProxy, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_GTFProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("Proxy class for access to GTF fields.\n\n This class represents a GTF entry for fast read-access.\n Write-access has been added as well, though some care must\n be taken. If any of the string fields (contig, source, ...)\n are set, the new value is tied to the lifetime of the\n argument that was supplied.\n\n The only exception is the attributes field when set from\n a dictionary - this field will manage its own memory.\n\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_10TabProxies_GTFProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_10TabProxies_GTFProxy, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_10TabProxies_GTFProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_vtable_10TabProxies_NamedTupleProxy;
+
+static PyObject *__pyx_tp_new_10TabProxies_NamedTupleProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy *p;
+ PyObject *o = __pyx_tp_new_10TabProxies_TupleProxy(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_10TabProxies_NamedTupleProxy *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+ return o;
+}
+
+static PyObject *__pyx_tp_getattro_10TabProxies_NamedTupleProxy(PyObject *o, PyObject *n) {
+ PyObject *v = PyObject_GenericGetAttr(o, n);
+ if (!v && PyErr_ExceptionMatches(PyExc_AttributeError)) {
+ PyErr_Clear();
+ v = __pyx_pf_10TabProxies_15NamedTupleProxy___getattr__(o, n);
+ }
+ return v;
+}
+
+static int __pyx_tp_setattro_10TabProxies_NamedTupleProxy(PyObject *o, PyObject *n, PyObject *v) {
+ if (v) {
+ return __pyx_pf_10TabProxies_15NamedTupleProxy___setattr__(o, n, v);
+ }
+ else {
+ if (__pyx_ptype_10TabProxies_TupleProxy->tp_setattro)
+ return __pyx_ptype_10TabProxies_TupleProxy->tp_setattro(o, n, v);
+ return PyObject_GenericSetAttr(o, n, 0);
+ }
+}
+
+static PyMethodDef __pyx_methods_10TabProxies_NamedTupleProxy[] = {
+ {__Pyx_NAMESTR("__getattr__"), (PyCFunction)__pyx_pf_10TabProxies_15NamedTupleProxy___getattr__, METH_O|METH_COEXIST, __Pyx_DOCSTR(0)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_NamedTupleProxy = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_NamedTupleProxy = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_NamedTupleProxy = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_NamedTupleProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_10TabProxies_NamedTupleProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("TabProxies.NamedTupleProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_10TabProxies_NamedTupleProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_10TabProxies_TupleProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_NamedTupleProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_NamedTupleProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_NamedTupleProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ __pyx_tp_getattro_10TabProxies_NamedTupleProxy, /*tp_getattro*/
+ __pyx_tp_setattro_10TabProxies_NamedTupleProxy, /*tp_setattro*/
+ &__pyx_tp_as_buffer_NamedTupleProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ 0, /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_10TabProxies_NamedTupleProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_10TabProxies_NamedTupleProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_10TabProxies_BedProxy __pyx_vtable_10TabProxies_BedProxy;
+
+static PyObject *__pyx_tp_new_10TabProxies_BedProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_10TabProxies_BedProxy *p;
+ PyObject *o = __pyx_tp_new_10TabProxies_TupleProxy(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_10TabProxies_BedProxy *)o);
+ p->__pyx_base.__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_10TabProxies_BedProxy;
+ return o;
+}
+
+static int __pyx_tp_setattro_10TabProxies_BedProxy(PyObject *o, PyObject *n, PyObject *v) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8BedProxy___setattr__(o, n, v);
+ }
+ else {
+ if (__pyx_ptype_10TabProxies_NamedTupleProxy->tp_setattro)
+ return __pyx_ptype_10TabProxies_NamedTupleProxy->tp_setattro(o, n, v);
+ return PyObject_GenericSetAttr(o, n, 0);
+ }
+}
+
+static PyMethodDef __pyx_methods_10TabProxies_BedProxy[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_BedProxy = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_BedProxy = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_BedProxy = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_BedProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_10TabProxies_BedProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("TabProxies.BedProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_10TabProxies_BedProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_10TabProxies_TupleProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_BedProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_BedProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_BedProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ __pyx_pf_10TabProxies_8BedProxy___str__, /*tp_str*/
+ 0, /*tp_getattro*/
+ __pyx_tp_setattro_10TabProxies_BedProxy, /*tp_setattro*/
+ &__pyx_tp_as_buffer_BedProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("Proxy class for access to Bed fields.\n\n This class represents a GTF entry for fast read-access.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_10TabProxies_BedProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_10TabProxies_BedProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_10TabProxies_VCFProxy __pyx_vtable_10TabProxies_VCFProxy;
+
+static PyObject *__pyx_tp_new_10TabProxies_VCFProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_10TabProxies_VCFProxy *p;
+ PyObject *o = __pyx_tp_new_10TabProxies_TupleProxy(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_10TabProxies_VCFProxy *)o);
+ p->__pyx_base.__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_10TabProxies_VCFProxy;
+ if (__pyx_pf_10TabProxies_8VCFProxy___cinit__(o, __pyx_empty_tuple, NULL) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static int __pyx_tp_setattro_10TabProxies_VCFProxy(PyObject *o, PyObject *n, PyObject *v) {
+ if (v) {
+ return __pyx_pf_10TabProxies_8VCFProxy___setattr__(o, n, v);
+ }
+ else {
+ if (__pyx_ptype_10TabProxies_NamedTupleProxy->tp_setattro)
+ return __pyx_ptype_10TabProxies_NamedTupleProxy->tp_setattro(o, n, v);
+ return PyObject_GenericSetAttr(o, n, 0);
+ }
+}
+
+static PyMethodDef __pyx_methods_10TabProxies_VCFProxy[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_VCFProxy = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_VCFProxy = {
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+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_VCFProxy = {
+ __pyx_pf_10TabProxies_8VCFProxy___len__, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_VCFProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_10TabProxies_VCFProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("TabProxies.VCFProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_10TabProxies_VCFProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_10TabProxies_TupleProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_VCFProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_VCFProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_VCFProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ __pyx_tp_setattro_10TabProxies_VCFProxy, /*tp_setattro*/
+ &__pyx_tp_as_buffer_VCFProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("Proxy class for access to VCF fields.\n\n The genotypes are accessed via index.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_10TabProxies_VCFProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_10TabProxies_VCFProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyMethodDef __pyx_methods[] = {
+ {__Pyx_NAMESTR("toDot"), (PyCFunction)__pyx_pf_10TabProxies_toDot, METH_O, __Pyx_DOCSTR(__pyx_doc_10TabProxies_toDot)},
+ {__Pyx_NAMESTR("quote"), (PyCFunction)__pyx_pf_10TabProxies_quote, METH_O, __Pyx_DOCSTR(__pyx_doc_10TabProxies_quote)},
+ {0, 0, 0, 0}
+};
+
+#if PY_MAJOR_VERSION >= 3
+static struct PyModuleDef __pyx_moduledef = {
+ PyModuleDef_HEAD_INIT,
+ __Pyx_NAMESTR("TabProxies"),
+ 0, /* m_doc */
+ -1, /* m_size */
+ __pyx_methods /* m_methods */,
+ NULL, /* m_reload */
+ NULL, /* m_traverse */
+ NULL, /* m_clear */
+ NULL /* m_free */
+};
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+ __pyx_builtin_IndexError = __Pyx_GetName(__pyx_b, __pyx_n_s__IndexError); if (!__pyx_builtin_IndexError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 148; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_StopIteration = __Pyx_GetName(__pyx_b, __pyx_n_s__StopIteration); if (!__pyx_builtin_StopIteration) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 196; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ __pyx_builtin_TypeError = __Pyx_GetName(__pyx_b, __pyx_n_s__TypeError); if (!__pyx_builtin_TypeError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 378; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_AttributeError = __Pyx_GetName(__pyx_b, __pyx_n_s__AttributeError); if (!__pyx_builtin_AttributeError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 462; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+PyMODINIT_FUNC PyInit_TabProxies(void); /*proto*/
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+ #ifdef __pyx_binding_PyCFunctionType_USED
+ if (__pyx_binding_PyCFunctionType_init() < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ PyEval_InitThreads();
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+ Py_INCREF(__pyx_m);
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+ if (!__pyx_b) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ if (__Pyx_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ /*--- Initialize various global constants etc. ---*/
+ if (unlikely(__Pyx_InitGlobals() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ {
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+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
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+ {
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+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
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+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_10TupleProxy___next__;
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+ {
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+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_10TabProxies_10TupleProxy___str__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_10TabProxies_10TupleProxy___str__.doc = __pyx_doc_10TabProxies_10TupleProxy___str__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_10TupleProxy___str__;
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+ if (__Pyx_SetVtable(__pyx_type_10TabProxies_TupleProxy.tp_dict, __pyx_vtabptr_10TabProxies_TupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 20; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "TupleProxy", (PyObject *)&__pyx_type_10TabProxies_TupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 20; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_10TabProxies_TupleProxy = &__pyx_type_10TabProxies_TupleProxy;
+ __pyx_vtabptr_10TabProxies_GTFProxy = &__pyx_vtable_10TabProxies_GTFProxy;
+ __pyx_vtable_10TabProxies_GTFProxy.__pyx_base = *__pyx_vtabptr_10TabProxies_TupleProxy;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_10TabProxies_GTFProxy.__pyx_base.getMaxFields = (int (*)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t))__pyx_f_10TabProxies_8GTFProxy_getMaxFields;
+ __pyx_vtable_10TabProxies_GTFProxy.__pyx_base.update = (PyObject *(*)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t))__pyx_f_10TabProxies_8GTFProxy_update;
+ #else
+ *(void(**)(void))&__pyx_vtable_10TabProxies_GTFProxy.__pyx_base.getMaxFields = (void(*)(void))__pyx_f_10TabProxies_8GTFProxy_getMaxFields;
+ *(void(**)(void))&__pyx_vtable_10TabProxies_GTFProxy.__pyx_base.update = (void(*)(void))__pyx_f_10TabProxies_8GTFProxy_update;
+ #endif
+ __pyx_type_10TabProxies_GTFProxy.tp_base = __pyx_ptype_10TabProxies_TupleProxy;
+ if (PyType_Ready(&__pyx_type_10TabProxies_GTFProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 231; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_10TabProxies_GTFProxy, "__getattr__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 231; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_10TabProxies_8GTFProxy___getattr__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_10TabProxies_8GTFProxy___getattr__.doc = __pyx_doc_10TabProxies_8GTFProxy___getattr__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_8GTFProxy___getattr__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_10TabProxies_GTFProxy.tp_dict, __pyx_vtabptr_10TabProxies_GTFProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 231; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "GTFProxy", (PyObject *)&__pyx_type_10TabProxies_GTFProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 231; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_10TabProxies_GTFProxy = &__pyx_type_10TabProxies_GTFProxy;
+ __pyx_vtabptr_10TabProxies_NamedTupleProxy = &__pyx_vtable_10TabProxies_NamedTupleProxy;
+ __pyx_vtable_10TabProxies_NamedTupleProxy.__pyx_base = *__pyx_vtabptr_10TabProxies_TupleProxy;
+ __pyx_type_10TabProxies_NamedTupleProxy.tp_base = __pyx_ptype_10TabProxies_TupleProxy;
+ if (PyType_Ready(&__pyx_type_10TabProxies_NamedTupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 488; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_10TabProxies_NamedTupleProxy, "__setattr__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 488; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_10TabProxies_15NamedTupleProxy___setattr__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_10TabProxies_15NamedTupleProxy___setattr__.doc = __pyx_doc_10TabProxies_15NamedTupleProxy___setattr__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_15NamedTupleProxy___setattr__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_10TabProxies_NamedTupleProxy.tp_dict, __pyx_vtabptr_10TabProxies_NamedTupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 488; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "NamedTupleProxy", (PyObject *)&__pyx_type_10TabProxies_NamedTupleProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 488; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_10TabProxies_NamedTupleProxy = &__pyx_type_10TabProxies_NamedTupleProxy;
+ __pyx_vtabptr_10TabProxies_BedProxy = &__pyx_vtable_10TabProxies_BedProxy;
+ __pyx_vtable_10TabProxies_BedProxy.__pyx_base = *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_10TabProxies_BedProxy.__pyx_base.__pyx_base.getMaxFields = (int (*)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t))__pyx_f_10TabProxies_8BedProxy_getMaxFields;
+ __pyx_vtable_10TabProxies_BedProxy.__pyx_base.__pyx_base.update = (PyObject *(*)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t))__pyx_f_10TabProxies_8BedProxy_update;
+ #else
+ *(void(**)(void))&__pyx_vtable_10TabProxies_BedProxy.__pyx_base.__pyx_base.getMaxFields = (void(*)(void))__pyx_f_10TabProxies_8BedProxy_getMaxFields;
+ *(void(**)(void))&__pyx_vtable_10TabProxies_BedProxy.__pyx_base.__pyx_base.update = (void(*)(void))__pyx_f_10TabProxies_8BedProxy_update;
+ #endif
+ __pyx_type_10TabProxies_BedProxy.tp_base = __pyx_ptype_10TabProxies_NamedTupleProxy;
+ if (PyType_Ready(&__pyx_type_10TabProxies_BedProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 507; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_10TabProxies_BedProxy, "__setattr__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 507; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_10TabProxies_8BedProxy___setattr__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_10TabProxies_8BedProxy___setattr__.doc = __pyx_doc_10TabProxies_8BedProxy___setattr__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_8BedProxy___setattr__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_10TabProxies_BedProxy.tp_dict, __pyx_vtabptr_10TabProxies_BedProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 507; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "BedProxy", (PyObject *)&__pyx_type_10TabProxies_BedProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 507; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_10TabProxies_BedProxy = &__pyx_type_10TabProxies_BedProxy;
+ __pyx_vtabptr_10TabProxies_VCFProxy = &__pyx_vtable_10TabProxies_VCFProxy;
+ __pyx_vtable_10TabProxies_VCFProxy.__pyx_base = *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_10TabProxies_VCFProxy.__pyx_base.__pyx_base.update = (PyObject *(*)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t))__pyx_f_10TabProxies_8VCFProxy_update;
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+ *(void(**)(void))&__pyx_vtable_10TabProxies_VCFProxy.__pyx_base.__pyx_base.update = (void(*)(void))__pyx_f_10TabProxies_8VCFProxy_update;
+ #endif
+ __pyx_type_10TabProxies_VCFProxy.tp_base = __pyx_ptype_10TabProxies_NamedTupleProxy;
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+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_10TabProxies_VCFProxy, "__setattr__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 573; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
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+ __pyx_wrapperbase_10TabProxies_8VCFProxy___setattr__.doc = __pyx_doc_10TabProxies_8VCFProxy___setattr__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_10TabProxies_8VCFProxy___setattr__;
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+ if (__Pyx_SetAttrString(__pyx_m, "VCFProxy", (PyObject *)&__pyx_type_10TabProxies_VCFProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 573; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_10TabProxies_VCFProxy = &__pyx_type_10TabProxies_VCFProxy;
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+ __Pyx_GOTREF(__pyx_t_1);
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+ } else {
+ for (name = first_kw_arg; *name; name++) {
+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) break;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+ _PyString_Eq(**name, key)) break;
+ #endif
+ }
+ if (*name) {
+ values[name-argnames] = value;
+ } else {
+ /* unexpected keyword found */
+ for (name=argnames; name != first_kw_arg; name++) {
+ if (**name == key) goto arg_passed_twice;
+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+ _PyString_Eq(**name, key)) goto arg_passed_twice;
+ #endif
+ }
+ if (kwds2) {
+ if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
+ } else {
+ goto invalid_keyword;
+ }
+ }
+ }
+ }
+ }
+ return 0;
+arg_passed_twice:
+ __Pyx_RaiseDoubleKeywordsError(function_name, **name);
+ goto bad;
+invalid_keyword_type:
+ PyErr_Format(PyExc_TypeError,
+ "%s() keywords must be strings", function_name);
+ goto bad;
+invalid_keyword:
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION < 3
+ "%s() got an unexpected keyword argument '%s'",
+ function_name, PyString_AsString(key));
+ #else
+ "%s() got an unexpected keyword argument '%U'",
+ function_name, key);
+ #endif
+bad:
+ return -1;
+}
+
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj) {
+ PyObject* float_value;
+ if (Py_TYPE(obj)->tp_as_number && Py_TYPE(obj)->tp_as_number->nb_float) {
+ return PyFloat_AsDouble(obj);
+ } else if (PyUnicode_CheckExact(obj) || PyBytes_CheckExact(obj)) {
+#if PY_MAJOR_VERSION >= 3
+ float_value = PyFloat_FromString(obj);
+#else
+ float_value = PyFloat_FromString(obj, 0);
+#endif
+ } else {
+ PyObject* args = PyTuple_New(1);
+ if (unlikely(!args)) goto bad;
+ PyTuple_SET_ITEM(args, 0, obj);
+ float_value = PyObject_Call((PyObject*)&PyFloat_Type, args, 0);
+ PyTuple_SET_ITEM(args, 0, 0);
+ Py_DECREF(args);
+ }
+ if (likely(float_value)) {
+ double value = PyFloat_AS_DOUBLE(float_value);
+ Py_DECREF(float_value);
+ return value;
+ }
+bad:
+ return (double)-1;
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
+ PyErr_Format(PyExc_ValueError,
+ #if PY_VERSION_HEX < 0x02050000
+ "need more than %d value%s to unpack", (int)index,
+ #else
+ "need more than %zd value%s to unpack", index,
+ #endif
+ (index == 1) ? "" : "s");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
+ PyErr_Format(PyExc_ValueError,
+ #if PY_VERSION_HEX < 0x02050000
+ "too many values to unpack (expected %d)", (int)expected);
+ #else
+ "too many values to unpack (expected %zd)", expected);
+ #endif
+}
+
+static PyObject *__Pyx_UnpackItem(PyObject *iter, Py_ssize_t index) {
+ PyObject *item;
+ if (!(item = PyIter_Next(iter))) {
+ if (!PyErr_Occurred()) {
+ __Pyx_RaiseNeedMoreValuesError(index);
+ }
+ }
+ return item;
+}
+
+static int __Pyx_EndUnpack(PyObject *iter, Py_ssize_t expected) {
+ PyObject *item;
+ if ((item = PyIter_Next(iter))) {
+ Py_DECREF(item);
+ __Pyx_RaiseTooManyValuesError(expected);
+ return -1;
+ }
+ else if (!PyErr_Occurred())
+ return 0;
+ else
+ return -1;
+}
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->exc_type;
+ *value = tstate->exc_value;
+ *tb = tstate->exc_traceback;
+ Py_XINCREF(*type);
+ Py_XINCREF(*value);
+ Py_XINCREF(*tb);
+}
+
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = type;
+ tstate->exc_value = value;
+ tstate->exc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
+ PyObject *py_import = 0;
+ PyObject *empty_list = 0;
+ PyObject *module = 0;
+ PyObject *global_dict = 0;
+ PyObject *empty_dict = 0;
+ PyObject *list;
+ py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
+ if (!py_import)
+ goto bad;
+ if (from_list)
+ list = from_list;
+ else {
+ empty_list = PyList_New(0);
+ if (!empty_list)
+ goto bad;
+ list = empty_list;
+ }
+ global_dict = PyModule_GetDict(__pyx_m);
+ if (!global_dict)
+ goto bad;
+ empty_dict = PyDict_New();
+ if (!empty_dict)
+ goto bad;
+ module = PyObject_CallFunctionObjArgs(py_import,
+ name, global_dict, empty_dict, list, NULL);
+bad:
+ Py_XDECREF(empty_list);
+ Py_XDECREF(py_import);
+ Py_XDECREF(empty_dict);
+ return module;
+}
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+
+ tmp_type = tstate->curexc_type;
+ tmp_value = tstate->curexc_value;
+ tmp_tb = tstate->curexc_traceback;
+ tstate->curexc_type = type;
+ tstate->curexc_value = value;
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->curexc_type;
+ *value = tstate->curexc_value;
+ *tb = tstate->curexc_traceback;
+
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+}
+
+
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ Py_XINCREF(type);
+ Py_XINCREF(value);
+ Py_XINCREF(tb);
+ /* First, check the traceback argument, replacing None with NULL. */
+ if (tb == Py_None) {
+ Py_DECREF(tb);
+ tb = 0;
+ }
+ else if (tb != NULL && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto raise_error;
+ }
+ /* Next, replace a missing value with None */
+ if (value == NULL) {
+ value = Py_None;
+ Py_INCREF(value);
+ }
+ #if PY_VERSION_HEX < 0x02050000
+ if (!PyClass_Check(type))
+ #else
+ if (!PyType_Check(type))
+ #endif
+ {
+ /* Raising an instance. The value should be a dummy. */
+ if (value != Py_None) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto raise_error;
+ }
+ /* Normalize to raise <class>, <instance> */
+ Py_DECREF(value);
+ value = type;
+ #if PY_VERSION_HEX < 0x02050000
+ if (PyInstance_Check(type)) {
+ type = (PyObject*) ((PyInstanceObject*)type)->in_class;
+ Py_INCREF(type);
+ }
+ else {
+ type = 0;
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception must be an old-style class or instance");
+ goto raise_error;
+ }
+ #else
+ type = (PyObject*) Py_TYPE(type);
+ Py_INCREF(type);
+ if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto raise_error;
+ }
+ #endif
+ }
+
+ __Pyx_ErrRestore(type, value, tb);
+ return;
+raise_error:
+ Py_XDECREF(value);
+ Py_XDECREF(type);
+ Py_XDECREF(tb);
+ return;
+}
+
+#else /* Python 3+ */
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ if (tb == Py_None) {
+ tb = 0;
+ } else if (tb && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto bad;
+ }
+ if (value == Py_None)
+ value = 0;
+
+ if (PyExceptionInstance_Check(type)) {
+ if (value) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto bad;
+ }
+ value = type;
+ type = (PyObject*) Py_TYPE(value);
+ } else if (!PyExceptionClass_Check(type)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto bad;
+ }
+
+ PyErr_SetObject(type, value);
+
+ if (tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ PyObject* tmp_tb = tstate->curexc_traceback;
+ if (tb != tmp_tb) {
+ Py_INCREF(tb);
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_tb);
+ }
+ }
+
+bad:
+ return;
+}
+#endif
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t val) {
+ const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(uint32_t) == sizeof(char)) ||
+ (sizeof(uint32_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(uint32_t) == sizeof(int)) ||
+ (sizeof(uint32_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(uint32_t),
+ little, !is_unsigned);
+ }
+}
+
+static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject* x) {
+ const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if (sizeof(uint32_t) == sizeof(char)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedChar(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedChar(x);
+ } else if (sizeof(uint32_t) == sizeof(short)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedShort(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedShort(x);
+ } else if (sizeof(uint32_t) == sizeof(int)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedInt(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedInt(x);
+ } else if (sizeof(uint32_t) == sizeof(long)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedLong(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedLong(x);
+ } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedLongLong(x);
+ } else {
+ uint32_t val;
+ PyObject *v = __Pyx_PyNumber_Int(x);
+ #if PY_VERSION_HEX < 0x03000000
+ if (likely(v) && !PyLong_Check(v)) {
+ PyObject *tmp = v;
+ v = PyNumber_Long(tmp);
+ Py_DECREF(tmp);
+ }
+ #endif
+ if (likely(v)) {
+ int one = 1; int is_little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ int ret = _PyLong_AsByteArray((PyLongObject *)v,
+ bytes, sizeof(val),
+ is_little, !is_unsigned);
+ Py_DECREF(v);
+ if (likely(!ret))
+ return val;
+ }
+ return (uint32_t)-1;
+ }
+}
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
+ const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned char" :
+ "value too large to convert to unsigned char");
+ }
+ return (unsigned char)-1;
+ }
+ return (unsigned char)val;
+ }
+ return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
+ const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned short" :
+ "value too large to convert to unsigned short");
+ }
+ return (unsigned short)-1;
+ }
+ return (unsigned short)val;
+ }
+ return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
+ const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned int" :
+ "value too large to convert to unsigned int");
+ }
+ return (unsigned int)-1;
+ }
+ return (unsigned int)val;
+ }
+ return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
+ const char neg_one = (char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to char" :
+ "value too large to convert to char");
+ }
+ return (char)-1;
+ }
+ return (char)val;
+ }
+ return (char)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
+ const short neg_one = (short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to short" :
+ "value too large to convert to short");
+ }
+ return (short)-1;
+ }
+ return (short)val;
+ }
+ return (short)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
+ const signed char neg_one = (signed char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed char" :
+ "value too large to convert to signed char");
+ }
+ return (signed char)-1;
+ }
+ return (signed char)val;
+ }
+ return (signed char)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
+ const signed short neg_one = (signed short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed short" :
+ "value too large to convert to signed short");
+ }
+ return (signed short)-1;
+ }
+ return (signed short)val;
+ }
+ return (signed short)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
+ const signed int neg_one = (signed int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed int" :
+ "value too large to convert to signed int");
+ }
+ return (signed int)-1;
+ }
+ return (signed int)val;
+ }
+ return (signed int)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
+ const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return (unsigned long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ unsigned long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned long)-1;
+ val = __Pyx_PyInt_AsUnsignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
+ const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return (unsigned PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ unsigned PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
+ const long neg_one = (long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return (long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (long)-1;
+ val = __Pyx_PyInt_AsLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
+ const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return (PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
+ const signed long neg_one = (signed long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return (signed long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ signed long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed long)-1;
+ val = __Pyx_PyInt_AsSignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
+ const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return (signed PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ signed PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsSignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static void __Pyx_WriteUnraisable(const char *name) {
+ PyObject *old_exc, *old_val, *old_tb;
+ PyObject *ctx;
+ __Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
+ #if PY_MAJOR_VERSION < 3
+ ctx = PyString_FromString(name);
+ #else
+ ctx = PyUnicode_FromString(name);
+ #endif
+ __Pyx_ErrRestore(old_exc, old_val, old_tb);
+ if (!ctx) {
+ PyErr_WriteUnraisable(Py_None);
+ } else {
+ PyErr_WriteUnraisable(ctx);
+ Py_DECREF(ctx);
+ }
+}
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+ PyObject *ob = PyCapsule_New(vtable, 0, 0);
+#else
+ PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
+#endif
+ if (!ob)
+ goto bad;
+ if (PyDict_SetItemString(dict, "__pyx_vtable__", ob) < 0)
+ goto bad;
+ Py_DECREF(ob);
+ return 0;
+bad:
+ Py_XDECREF(ob);
+ return -1;
+}
+
+#ifndef __PYX_HAVE_RT_ImportType
+#define __PYX_HAVE_RT_ImportType
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
+ long size, int strict)
+{
+ PyObject *py_module = 0;
+ PyObject *result = 0;
+ PyObject *py_name = 0;
+ char warning[200];
+
+ py_module = __Pyx_ImportModule(module_name);
+ if (!py_module)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(class_name);
+ #else
+ py_name = PyUnicode_FromString(class_name);
+ #endif
+ if (!py_name)
+ goto bad;
+ result = PyObject_GetAttr(py_module, py_name);
+ Py_DECREF(py_name);
+ py_name = 0;
+ Py_DECREF(py_module);
+ py_module = 0;
+ if (!result)
+ goto bad;
+ if (!PyType_Check(result)) {
+ PyErr_Format(PyExc_TypeError,
+ "%s.%s is not a type object",
+ module_name, class_name);
+ goto bad;
+ }
+ if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
+ PyOS_snprintf(warning, sizeof(warning),
+ "%s.%s size changed, may indicate binary incompatibility",
+ module_name, class_name);
+ #if PY_VERSION_HEX < 0x02050000
+ PyErr_Warn(NULL, warning);
+ #else
+ PyErr_WarnEx(NULL, warning, 0);
+ #endif
+ }
+ else if (((PyTypeObject *)result)->tp_basicsize != size) {
+ PyErr_Format(PyExc_ValueError,
+ "%s.%s has the wrong size, try recompiling",
+ module_name, class_name);
+ goto bad;
+ }
+ return (PyTypeObject *)result;
+bad:
+ Py_XDECREF(py_module);
+ Py_XDECREF(result);
+ return 0;
+}
+#endif
+
+#ifndef __PYX_HAVE_RT_ImportModule
+#define __PYX_HAVE_RT_ImportModule
+static PyObject *__Pyx_ImportModule(const char *name) {
+ PyObject *py_name = 0;
+ PyObject *py_module = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(name);
+ #else
+ py_name = PyUnicode_FromString(name);
+ #endif
+ if (!py_name)
+ goto bad;
+ py_module = PyImport_Import(py_name);
+ Py_DECREF(py_name);
+ return py_module;
+bad:
+ Py_XDECREF(py_name);
+ return 0;
+}
+#endif
+
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+
+static void __Pyx_AddTraceback(const char *funcname) {
+ PyObject *py_srcfile = 0;
+ PyObject *py_funcname = 0;
+ PyObject *py_globals = 0;
+ PyCodeObject *py_code = 0;
+ PyFrameObject *py_frame = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_srcfile = PyString_FromString(__pyx_filename);
+ #else
+ py_srcfile = PyUnicode_FromString(__pyx_filename);
+ #endif
+ if (!py_srcfile) goto bad;
+ if (__pyx_clineno) {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #else
+ py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #endif
+ }
+ else {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromString(funcname);
+ #else
+ py_funcname = PyUnicode_FromString(funcname);
+ #endif
+ }
+ if (!py_funcname) goto bad;
+ py_globals = PyModule_GetDict(__pyx_m);
+ if (!py_globals) goto bad;
+ py_code = PyCode_New(
+ 0, /*int argcount,*/
+ #if PY_MAJOR_VERSION >= 3
+ 0, /*int kwonlyargcount,*/
+ #endif
+ 0, /*int nlocals,*/
+ 0, /*int stacksize,*/
+ 0, /*int flags,*/
+ __pyx_empty_bytes, /*PyObject *code,*/
+ __pyx_empty_tuple, /*PyObject *consts,*/
+ __pyx_empty_tuple, /*PyObject *names,*/
+ __pyx_empty_tuple, /*PyObject *varnames,*/
+ __pyx_empty_tuple, /*PyObject *freevars,*/
+ __pyx_empty_tuple, /*PyObject *cellvars,*/
+ py_srcfile, /*PyObject *filename,*/
+ py_funcname, /*PyObject *name,*/
+ __pyx_lineno, /*int firstlineno,*/
+ __pyx_empty_bytes /*PyObject *lnotab*/
+ );
+ if (!py_code) goto bad;
+ py_frame = PyFrame_New(
+ PyThreadState_GET(), /*PyThreadState *tstate,*/
+ py_code, /*PyCodeObject *code,*/
+ py_globals, /*PyObject *globals,*/
+ 0 /*PyObject *locals*/
+ );
+ if (!py_frame) goto bad;
+ py_frame->f_lineno = __pyx_lineno;
+ PyTraceBack_Here(py_frame);
+bad:
+ Py_XDECREF(py_srcfile);
+ Py_XDECREF(py_funcname);
+ Py_XDECREF(py_code);
+ Py_XDECREF(py_frame);
+}
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+ while (t->p) {
+ #if PY_MAJOR_VERSION < 3
+ if (t->is_unicode) {
+ *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+ } else if (t->intern) {
+ *t->p = PyString_InternFromString(t->s);
+ } else {
+ *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+ }
+ #else /* Python 3+ has unicode identifiers */
+ if (t->is_unicode | t->is_str) {
+ if (t->intern) {
+ *t->p = PyUnicode_InternFromString(t->s);
+ } else if (t->encoding) {
+ *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
+ } else {
+ *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
+ }
+ } else {
+ *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
+ }
+ #endif
+ if (!*t->p)
+ return -1;
+ ++t;
+ }
+ return 0;
+}
+
+/* Type Conversion Functions */
+
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+ int is_true = x == Py_True;
+ if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+ else return PyObject_IsTrue(x);
+}
+
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
+ PyNumberMethods *m;
+ const char *name = NULL;
+ PyObject *res = NULL;
+#if PY_VERSION_HEX < 0x03000000
+ if (PyInt_Check(x) || PyLong_Check(x))
+#else
+ if (PyLong_Check(x))
+#endif
+ return Py_INCREF(x), x;
+ m = Py_TYPE(x)->tp_as_number;
+#if PY_VERSION_HEX < 0x03000000
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Int(x);
+ }
+ else if (m && m->nb_long) {
+ name = "long";
+ res = PyNumber_Long(x);
+ }
+#else
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Long(x);
+ }
+#endif
+ if (res) {
+#if PY_VERSION_HEX < 0x03000000
+ if (!PyInt_Check(res) && !PyLong_Check(res)) {
+#else
+ if (!PyLong_Check(res)) {
+#endif
+ PyErr_Format(PyExc_TypeError,
+ "__%s__ returned non-%s (type %.200s)",
+ name, name, Py_TYPE(res)->tp_name);
+ Py_DECREF(res);
+ return NULL;
+ }
+ }
+ else if (!PyErr_Occurred()) {
+ PyErr_SetString(PyExc_TypeError,
+ "an integer is required");
+ }
+ return res;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+ Py_ssize_t ival;
+ PyObject* x = PyNumber_Index(b);
+ if (!x) return -1;
+ ival = PyInt_AsSsize_t(x);
+ Py_DECREF(x);
+ return ival;
+}
+
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+#if PY_VERSION_HEX < 0x02050000
+ if (ival <= LONG_MAX)
+ return PyInt_FromLong((long)ival);
+ else {
+ unsigned char *bytes = (unsigned char *) &ival;
+ int one = 1; int little = (int)*(unsigned char*)&one;
+ return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
+ }
+#else
+ return PyInt_FromSize_t(ival);
+#endif
+}
+
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
+ unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
+ if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
+ return (size_t)-1;
+ } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "value too large to convert to size_t");
+ return (size_t)-1;
+ }
+ return (size_t)val;
+}
+
+
+#endif /* Py_PYTHON_H */
--- /dev/null
+cdef extern from "stdlib.h":
+ void free(void *)
+ void *malloc(size_t)
+ void *calloc(size_t,size_t)
+ void *realloc(void *,size_t)
+ int c_abs "abs" (int)
+ int c_abs "abs" (int)
+ int atoi( char *nptr)
+ long atol( char *nptr)
+ double atof( char *nptr)
+
+cdef extern from "Python.h":
+ ctypedef struct FILE
+ FILE* PyFile_AsFile(object)
+ char *fgets(char *str, int size, FILE *ifile)
+ int feof(FILE *stream)
+ size_t strlen(char *s)
+ size_t getline(char **lineptr, size_t *n, FILE *stream)
+ char *strstr(char *, char *)
+ char *strchr(char *string, int c)
+ int fileno(FILE *stream)
+
+cdef extern from "string.h":
+ int strcmp(char *s1, char *s2)
+ int strncmp(char *s1,char *s2,size_t len)
+ char *strcpy(char *dest,char *src)
+ char *strncpy(char *dest,char *src, size_t len)
+ char *strdup(char *)
+ char *strcat(char *,char *)
+ size_t strlen(char *s)
+ int memcmp( void * s1, void *s2, size_t len )
+ void *memcpy(void *dest, void *src, size_t n)
+ void *memchr(void *s, int c, size_t n)
+
+cdef extern from "stdint.h":
+ ctypedef int int64_t
+ ctypedef int int32_t
+ ctypedef int uint32_t
+ ctypedef int uint8_t
+ ctypedef int uint64_t
+
+cdef class TupleProxy:
+
+ cdef:
+ char * data
+ char ** fields
+ int nfields
+ int index
+ int nbytes
+ int offset
+ cdef bint is_modified
+
+ cdef int getMaxFields( self, size_t nbytes )
+
+ cdef take( self, char * buffer, size_t nbytes )
+ cdef present( self, char * buffer, size_t nbytes )
+ cdef copy( self, char * buffer, size_t nbytes )
+ cdef update( self, char * buffer, size_t nbytes )
+
+cdef class GTFProxy( TupleProxy) :
+
+ cdef:
+ char * contig
+ char * source
+ char * feature
+ uint32_t start
+ uint32_t end
+ char * score
+ char * strand
+ char * frame
+ char * attributes
+ cdef bint hasOwnAttributes
+
+ cdef int getMaxFields( self, size_t nbytes )
+ cdef update( self, char * buffer, size_t nbytes )
+
+cdef class NamedTupleProxy( TupleProxy) :
+ pass
+
+cdef class BedProxy( NamedTupleProxy) :
+
+ cdef:
+ char * contig
+ uint32_t start
+ uint32_t end
+ int bedfields
+
+ cdef int getMaxFields( self, size_t nbytes )
+ cdef update( self, char * buffer, size_t nbytes )
+
+cdef class VCFProxy( NamedTupleProxy) :
+
+ cdef:
+ char * contig
+ uint32_t pos
+
+ cdef update( self, char * buffer, size_t nbytes )
--- /dev/null
+import types
+from cpython cimport PyString_FromStringAndSize, PyString_AsString, PyString_AS_STRING
+
+cdef char * nextItem( char * buffer ):
+ cdef char * pos
+ pos = strchr( buffer, '\t' )
+ if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
+ pos[0] = '\0'
+ pos += 1
+ return pos
+
+cdef char *StrOrEmpty( char * buffer ):
+ if buffer == NULL: return ""
+ else: return buffer
+
+cdef int isNew( char * p, char * buffer, size_t nbytes ):
+ if p == NULL: return 0
+ return not (buffer <= p < buffer + nbytes )
+
+cdef class TupleProxy:
+ '''Proxy class for access to parsed row as a tuple.
+
+ This class represents a table row for fast read-access.
+
+ Access to individual fields is via the [] operator.
+
+ Only read-only access is implemented.
+ '''
+
+ def __cinit__(self ):
+ self.data = NULL
+ self.fields = NULL
+ self.index = 0
+ self.nbytes = 0
+ self.is_modified = 0
+ self.nfields = 0
+ # start counting at field offset
+ self.offset = 0
+
+ def __dealloc__(self):
+ cdef int x
+ if self.is_modified:
+ for x from 0 <= x < self.nfields:
+ if isNew( self.fields[x], self.data, self.nbytes ):
+ free( self.fields[x] )
+ self.fields[x] = NULL
+
+ if self.data != NULL: free(self.data)
+ if self.fields != NULL: free( self.fields )
+
+ cdef take( self, char * buffer, size_t nbytes ):
+ '''start presenting buffer.
+
+ Take ownership of the pointer.
+ '''
+ self.data = buffer
+ self.nbytes = nbytes
+ self.update( buffer, nbytes )
+
+ cdef present( self, char * buffer, size_t nbytes ):
+ '''start presenting buffer.
+
+ Do not take ownership of the pointer.
+ '''
+ self.update( buffer, nbytes )
+
+ cdef copy( self, char * buffer, size_t nbytes ):
+ '''start presenting buffer.
+
+ Take a copy of buffer.
+ '''
+ cdef int s
+ # +1 for '\0'
+ s = sizeof(char) * (nbytes + 1)
+ self.data = <char*>malloc( s )
+ if self.data == NULL:
+ raise ValueError("out of memory" )
+ self.nbytes = nbytes
+ memcpy( <char*>self.data, buffer, s )
+ self.update( self.data, nbytes )
+
+ cdef int getMaxFields( self, size_t nbytes ):
+ '''initialize fields.'''
+ return nbytes / 2
+
+ cdef update( self, char * buffer, size_t nbytes ):
+ '''update internal data.
+
+ Update starts work in buffer, thus can be used
+ to collect any number of fields until nbytes
+ is exhausted.
+
+ If max_fields is set, the number of fields is initialized to max_fields.
+
+ '''
+ cdef char * pos
+ cdef char * old_pos
+ cdef int field
+ cdef int max_fields, x
+
+ if buffer[nbytes] != 0:
+ raise ValueError( "incomplete line at %s" % buffer )
+
+ #################################
+ # clear data
+ if self.fields != NULL: free(self.fields)
+
+ for field from 0 <= field < self.nfields:
+ if isNew( self.fields[field], self.data, self.nbytes ):
+ free( self.fields[field] )
+
+ self.is_modified = self.nfields = 0
+
+ #################################
+ # allocate new
+ max_fields = self.getMaxFields( nbytes )
+ self.fields = <char **>calloc( max_fields, sizeof(char *) )
+ if self.fields == NULL:
+ raise ValueError("out of memory" )
+
+ #################################
+ # start filling
+ field = 0
+ self.fields[field] = pos = buffer
+ field += 1
+ old_pos = pos
+
+ while 1:
+
+ pos = <char*>memchr( pos, '\t', nbytes )
+ if pos == NULL: break
+ pos[0] = '\0'
+ pos += 1
+ self.fields[field] = pos
+ field += 1
+ if field >= max_fields:
+ raise ValueError("row too large - more than %i fields" % max_fields )
+ nbytes -= pos - old_pos
+ if nbytes < 0: break
+ old_pos = pos
+
+ self.nfields = field
+
+ def __getitem__( self, key ):
+
+ cdef int i = key
+ if i < 0: i += self.nfields
+ if i < 0: raise IndexError( "list index out of range" )
+ i += self.offset
+ if i >= self.nfields:
+ raise IndexError( "list index out of range" )
+ return self.fields[i]
+
+ def _setindex( self, index, value ):
+ '''set item at idx index.'''
+ cdef int idx = index
+ if idx < 0: raise IndexError( "list index out of range" )
+ if idx >= self.nfields:
+ raise IndexError( "list index out of range" )
+
+ if isNew( self.fields[idx], self.data, self.nbytes ):
+ free( self.fields[idx] )
+
+ self.is_modified = 1
+
+ if value == None:
+ self.fields[idx] = NULL
+ return
+
+ # conversion with error checking
+ cdef char * tmp = PyString_AsString( value )
+ self.fields[idx] = <char*>malloc( (strlen( tmp ) + 1) * sizeof(char) )
+ if self.fields[idx] == NULL:
+ raise ValueError("out of memory" )
+ strcpy( self.fields[idx], tmp )
+
+ def __setitem__(self, index, value ):
+ '''set item at *index* to *value*'''
+ cdef int i = index
+ if i < 0: i += self.nfields
+ i += self.offset
+
+ self._setindex( i, value )
+
+ def __len__(self):
+ return self.nfields
+
+ def __iter__(self):
+ self.index = 0
+ return self
+
+ def __next__(self):
+ """python version of next().
+ """
+ if self.index >= self.nfields:
+ raise StopIteration
+ cdef char * retval = self.fields[self.index]
+ self.index += 1
+ if retval == NULL: return None
+ else: return retval
+
+ def __str__(self):
+ '''return original data'''
+ # copy and replace \0 bytes with \t characters
+ if self.is_modified:
+ # todo: treat NULL values
+ return "\t".join( [StrOrEmpty( self.fields[x]) for x in xrange(0, self.nfields ) ] )
+ else:
+ cpy = <char*>calloc( sizeof(char), self.nbytes+1 )
+ if cpy == NULL:
+ raise ValueError("out of memory" )
+ memcpy( cpy, self.data, self.nbytes+1)
+ for x from 0 <= x < self.nbytes:
+ if cpy[x] == '\0': cpy[x] = '\t'
+ result = PyString_FromStringAndSize(cpy, self.nbytes)
+ free(cpy)
+ return result
+
+def toDot( v ):
+ '''convert value to '.' if None'''
+ if v == None: return "."
+ else: return str(v)
+
+def quote( v ):
+ '''return a quoted attribute.'''
+ if type(v) in types.StringTypes:
+ return '"%s"' % v
+ else:
+ return str(v)
+
+cdef class GTFProxy( TupleProxy ):
+ '''Proxy class for access to GTF fields.
+
+ This class represents a GTF entry for fast read-access.
+ Write-access has been added as well, though some care must
+ be taken. If any of the string fields (contig, source, ...)
+ are set, the new value is tied to the lifetime of the
+ argument that was supplied.
+
+ The only exception is the attributes field when set from
+ a dictionary - this field will manage its own memory.
+
+ '''
+
+ def __cinit__(self ):
+ # automatically calls TupleProxy.__cinit__
+ self.hasOwnAttributes = False
+
+ def __dealloc__(self):
+ # automatically calls TupleProxy.__dealloc__
+ if self.hasOwnAttributes:
+ free(self.attributes)
+
+ cdef int getMaxFields( self, size_t nbytes ):
+ '''return max number of fields.'''
+ return 9
+
+ cdef update( self, char * buffer, size_t nbytes ):
+ '''update internal data.
+
+ nbytes does not include the terminal '\0'.
+ '''
+ cdef int end
+ cdef char * cstart, * cend, * cscore
+ self.contig = buffer
+ cdef char * pos
+
+ if buffer[nbytes] != 0:
+ raise ValueError( "incomplete line at %s" % buffer )
+
+ self.source = pos = nextItem( buffer )
+ self.feature = pos = nextItem( pos )
+ cstart = pos = nextItem( pos )
+ cend = pos = nextItem( pos )
+ self.score = pos = nextItem( pos )
+ self.strand = pos = nextItem( pos )
+ self.frame = pos = nextItem( pos )
+ self.attributes = pos = nextItem( pos )
+
+ self.start = atoi( cstart ) - 1
+ self.end = atoi( cend )
+
+ property contig:
+ '''contig of feature.'''
+ def __get__( self ): return self.contig
+ def __set__( self, value ):
+ self.is_modified = True
+ self.contig = value
+
+ property feature:
+ '''feature name.'''
+ def __get__( self ): return self.feature
+ def __set__( self, value ):
+ self.is_modified = True
+ self.feature = value
+
+ property source:
+ '''feature source.'''
+ def __get__( self ): return self.source
+ def __set__( self, value ):
+ self.is_modified = True
+ self.source = value
+
+ property start:
+ '''feature start (in 0-based open/closed coordinates).'''
+ def __get__( self ): return self.start
+ def __set__( self, value ):
+ self.is_modified = True
+ self.start = value
+
+ property end:
+ '''feature end (in 0-based open/closed coordinates).'''
+ def __get__( self ): return self.end
+ def __set__( self, value ):
+ self.is_modified = True
+ self.end = value
+
+ property score:
+ '''feature score.'''
+ def __get__( self ):
+ if self.score[0] == '.' and self.score[1] == '\0' :
+ return None
+ else:
+ return atof(self.score)
+ def __set__( self, value ):
+ self.is_modified = True
+ self.score = value
+
+ property strand:
+ '''feature strand.'''
+ def __get__( self ): return self.strand
+ def __set__( self, value ):
+ self.is_modified = True
+ self.strand = value
+
+ property frame:
+ '''feature frame.'''
+ def __get__( self ): return self.frame
+ def __set__( self, value ):
+ self.is_modified = True
+ self.frame = value
+
+ property attributes:
+ '''feature attributes (as a string).'''
+ def __get__( self ): return self.attributes
+ def __set__( self, value ):
+ self.is_modified = True
+ self.attributes = value
+
+ def asDict( self ):
+ """parse attributes - return as dict
+ """
+
+ # remove comments
+ attributes = self.attributes
+
+ # separate into fields
+ fields = [ x.strip() for x in attributes.split(";")[:-1]]
+
+ result = {}
+
+ for f in fields:
+
+ d = [ x.strip() for x in f.split(" ")]
+
+ n,v = d[0], d[1]
+ if len(d) > 2: v = d[1:]
+
+ if v[0] == '"' and v[-1] == '"':
+ v = v[1:-1]
+ else:
+ ## try to convert to a value
+ try:
+ v = float( v )
+ v = int( v )
+ except ValueError:
+ pass
+ except TypeError:
+ pass
+
+ result[n] = v
+
+ return result
+
+ def fromDict( self, d ):
+ '''set attributes from a dictionary.'''
+ cdef char * p
+ cdef int l
+
+ # clean up if this field is set twice
+ if self.hasOwnAttributes:
+ free(self.attributes)
+
+ aa = []
+ for k,v in d.items():
+ if type(v) == types.StringType:
+ aa.append( '%s "%s"' % (k,v) )
+ else:
+ aa.append( '%s %s' % (k,str(v)) )
+
+ a = "; ".join( aa ) + ";"
+ p = a
+ l = len(a)
+ self.attributes = <char *>calloc( l + 1, sizeof(char) )
+ if self.attributes == NULL:
+ raise ValueError("out of memory" )
+ memcpy( self.attributes, p, l )
+
+ self.hasOwnAttributes = True
+ self.is_modified = True
+
+ def __str__(self):
+ cdef char * cpy
+ cdef int x
+
+ if self.is_modified:
+ return "\t".join(
+ (self.contig,
+ self.source,
+ self.feature,
+ str(self.start+1),
+ str(self.end),
+ toDot(self.score),
+ self.strand,
+ self.frame,
+ self.attributes ) )
+ else:
+ return TupleProxy.__str__(self)
+
+ def invert( self, int lcontig ):
+ '''invert coordinates to negative strand coordinates
+
+ This method will only act if the feature is on the
+ negative strand.'''
+
+ if self.strand[0] == '-':
+ start = min(self.start, self.end)
+ end = max(self.start, self.end)
+ self.start, self.end = lcontig - end, lcontig - start
+
+ def keys( self ):
+ '''return a list of attributes defined in this entry.'''
+ r = self.attributes
+ return [ x.strip().split(" ")[0] for x in r.split(";") if x.strip() != '' ]
+
+ def __getitem__(self, item):
+ return self.__getattr__( item )
+
+ def __getattr__(self, item ):
+ """Generic lookup of attribute from GFF/GTF attributes
+ Only called if there *isn't* an attribute with this name
+ """
+ cdef char * start
+ cdef char * query
+ cdef char * cpy
+ cdef char * end
+ cdef int l
+ query = item
+
+ start = strstr( self.attributes, query)
+ if start == NULL:
+ raise AttributeError("'GTFProxy' has no attribute '%s'" % item )
+
+ start += strlen(query) + 1
+ # skip gaps before
+ while start[0] == " ": start += 1
+ if start[0] == '"':
+ start += 1
+ end = start
+ while end[0] != '\0' and end[0] != '"': end += 1
+ l = end - start + 1
+ cpy = <char*>calloc( l, sizeof(char ) )
+ if cpy == NULL: raise ValueError("out of memory" )
+ memcpy( cpy, start, l )
+ cpy[l-1] = '\0'
+ result = cpy
+ free(cpy)
+ return result
+ else:
+ return start
+
+ def setAttribute( self, name, value ):
+ '''convenience method to set an attribute.'''
+ r = self.asDict()
+ r[name] = value
+ self.fromDict( r )
+
+cdef class NamedTupleProxy( TupleProxy ):
+
+ map_key2field = {}
+
+ def __setattr__(self, key, value ):
+ '''set attribute.'''
+ cdef int idx
+ idx, f = self.map_key2field[key]
+ if self.nfields < idx:
+ raise KeyError( "field %s not set" % key )
+ TupleProxy.__setitem__(self, idx, str(value) )
+
+ def __getattr__(self, key ):
+ cdef int idx
+ idx, f = self.map_key2field[key]
+ if self.nfields < idx:
+ raise KeyError( "field %s not set" % key )
+ return f( self.fields[idx] )
+
+cdef class BedProxy( NamedTupleProxy ):
+ '''Proxy class for access to Bed fields.
+
+ This class represents a GTF entry for fast read-access.
+ '''
+ map_key2field = {
+ 'contig' : (0, str),
+ 'start' : (1, int),
+ 'end' : (2, int),
+ 'name' : (3, str),
+ 'score' : (4, float),
+ 'strand' : (5, str),
+ 'thickStart' : (6,int ),
+ 'thickEnd' : (7,int),
+ 'itemRGB' : (8,str),
+ 'blockCount': (9,int),
+ 'blockSizes': (10,str),
+ 'blockStarts': (11,str), }
+
+ cdef int getMaxFields( self, size_t nbytes ):
+ '''return max number of fields.'''
+ return 12
+
+ cdef update( self, char * buffer, size_t nbytes ):
+ '''update internal data.
+
+ nbytes does not include the terminal '\0'.
+ '''
+ TupleProxy.update( self, buffer, nbytes )
+
+ if self.nfields < 3:
+ raise ValueError( "bed format requires at least three columns" )
+
+ # determines bed format
+ self.bedfields = self.nfields
+
+ # do automatic conversion
+ self.contig = self.fields[0]
+ self.start = atoi( self.fields[1] )
+ self.end = atoi( self.fields[2] )
+
+ # __setattr__ in base class seems to take precedence
+ # hence implement setters in __setattr__
+ #property start:
+ # def __get__( self ): return self.start
+ #property end:
+ # def __get__( self ): return self.end
+
+ def __str__(self):
+
+ cdef int save_fields = self.nfields
+ # ensure fields to use correct format
+ self.nfields = self.bedfields
+ retval = TupleProxy.__str__( self )
+ self.nfields = save_fields
+ return retval
+
+ def __setattr__(self, key, value ):
+ '''set attribute.'''
+ if key == "start": self.start = value
+ elif key == "end": self.end = value
+
+ cdef int idx
+ idx, f = self.map_key2field[key]
+ TupleProxy._setindex(self, idx, str(value) )
+
+cdef class VCFProxy( NamedTupleProxy ):
+ '''Proxy class for access to VCF fields.
+
+ The genotypes are accessed via index.
+ '''
+ map_key2field = {
+ 'contig' : (0, str),
+ 'pos' : (1, int),
+ 'id' : (2, str),
+ 'ref' : (3, str),
+ 'alt' : (4, str),
+ 'qual' : (5, str),
+ 'filter' : (6,str),
+ 'info' : (7,str),
+ 'format' : (8,str) }
+
+ def __cinit__(self ):
+ # automatically calls TupleProxy.__cinit__
+ # start indexed access at genotypes
+ self.offset = 9
+
+ cdef update( self, char * buffer, size_t nbytes ):
+ '''update internal data.
+
+ nbytes does not include the terminal '\0'.
+ '''
+ TupleProxy.update( self, buffer, nbytes )
+
+ self.contig = self.fields[0]
+ # vcf counts from 1 - correct here
+ self.pos = atoi( self.fields[1] ) - 1
+
+ def __len__(self):
+ return max(0, self.nfields - 9)
+
+ def __setattr__(self, key, value ):
+ '''set attribute.'''
+ if key == "pos":
+ self.pos = value
+ value += 1
+
+ cdef int idx
+ idx, f = self.map_key2field[key]
+ TupleProxy._setindex(self, idx, str(value) )
+
--- /dev/null
+#
+# Code to read, write and edit VCF files
+#
+# VCF lines are encoded as a dictionary with these keys (note: all lowercase):
+# 'chrom': string
+# 'pos': integer
+# 'id': string
+# 'ref': string
+# 'alt': list of strings
+# 'qual': integer
+# 'filter': None (missing value), or list of keys (strings); empty list parsed as ["PASS"]
+# 'info': dictionary of values (see below)
+# 'format': list of keys (strings)
+# sample keys: dictionary of values (see below)
+#
+# The sample keys are accessible through vcf.getsamples()
+#
+# A dictionary of values contains value keys (defined in ##INFO or ##FORMAT lines) which map
+# to a list, containign integers, floats, strings, or characters. Missing values are replaced
+# by a particular value, often -1 or .
+#
+# Genotypes are not stored as a string, but as a list of 1 or 3 elements (for haploid and diploid samples),
+# the first (and last) the integer representing an allele, and the second the separation character.
+# Note that there is just one genotype per sample, but for consistency the single element is stored in a list.
+#
+# Header lines other than ##INFO, ##FORMAT and ##FILTER are stored as (key, value) pairs and are accessible
+# through getheader()
+#
+# The VCF class can be instantiated with a 'regions' variable consisting of tuples (chrom,start,end) encoding
+# 0-based half-open segments. Only variants with a position inside the segment will be parsed. A regions
+# parser is available under parse_regions.
+#
+# When instantiated, a reference can be passed to the VCF class. This may be any class that supports a
+# fetch(chrom, start, end) method.
+#
+#
+#
+# NOTE: the position that is returned to Python is 0-based, NOT 1-based as in the VCF file.
+#
+#
+#
+# TODO:
+# only v4.0 writing is complete; alleles are not converted to v3.3 format
+#
+
+from collections import namedtuple, defaultdict
+from operator import itemgetter
+import sys, re, copy, bisect
+
+import pysam
+
+gtsRegEx = re.compile("[|/\\\\]")
+alleleRegEx = re.compile('^[ACGTN]+$')
+
+# Utility function. Uses 0-based coordinates
+def get_sequence(chrom, start, end, fa):
+ # obtain sequence from .fa file, without truncation
+ if end<=start: return ""
+ if not fa: return "N"*(end-start)
+ if start<0: return "N"*(-start) + get_sequence(chrom, 0, end, fa).upper()
+ sequence = fa.fetch(chrom, start, end).upper()
+ if len(sequence) < end-start: sequence += "N"*(end-start-len(sequence))
+ return sequence
+
+# Utility function. Parses a region string
+def parse_regions( string ):
+ result = []
+ for r in string.split(','):
+ elts = r.split(':')
+ chrom, start, end = elts[0], 0, 3000000000
+ if len(elts)==1: pass
+ elif len(elts)==2:
+ if len(elts[1])>0:
+ ielts = elts[1].split('-')
+ if len(ielts) != 2: ValueError("Don't understand region string '%s'" % r)
+ try: start, end = int(ielts[0])-1, int(ielts[1])
+ except: raise ValueError("Don't understand region string '%s'" % r)
+ else:
+ raise ValueError("Don't understand region string '%s'" % r)
+ result.append( (chrom,start,end) )
+ return result
+
+
+FORMAT = namedtuple('FORMAT','id numbertype number type description missingvalue')
+
+###########################################################################################################
+#
+# New class
+#
+###########################################################################################################
+
+class VCFRecord:
+ '''vcf record.
+
+ initialized from data and vcf meta
+ '''
+
+ data = None
+ vcf = None
+
+ def __init__(self, data, vcf):
+ self.data, self.vcf = data, vcf
+
+ if len(data) != len(self.vcf._samples):
+ self.error(str(data),
+ self.BAD_NUMBER_OF_COLUMNS,
+ "expected %s for %s samples (%s), got %s" % \
+ (len(self.vcf._samples),
+ len(self.vcf._samples),
+ self.vcf._samples,
+ len(data)))
+
+ property contig:
+ def contig( self ): return self.data[0]
+
+ property pos:
+ def __get__( self ):
+ return self.data.pos
+
+ property id:
+ def __get__( self ): return self.data[2]
+
+ property ref:
+ def __get__(self ):
+ # note: gerton substitutes reference if it can be fixed.
+ return self.data[3].upper()
+
+ property alt:
+ def __get__(self):
+ # convert v3.3 to v4.0 alleles below
+ alt = self.data[4]
+ if alt == ".": alt = []
+ else: alt = alt.upper().split(',')
+ return alt
+
+ property qual:
+ def __get__(self):
+ qual = self.data[5]
+ if qual == ".": qual = -1
+ else:
+ try: qual = float(qual)
+ except: self.error(line,self.QUAL_NOT_NUMERICAL)
+
+ property filter:
+ def __get__(self):
+ # postpone checking that filters exist. Encode missing filter or no filtering as empty list
+ if cols[6] == "." or cols[6] == "PASS" or cols[6] == "0": filter = []
+ else: filter = cols[6].split(';')
+
+ return filter
+
+ property info:
+ def __get__(self):
+ col = self.data[7]
+ # dictionary of keys, and list of values
+ info = {}
+ if col != ".":
+ for blurp in col.split(';'):
+ elts = blurp.split('=')
+ if len(elts) == 1: v = None
+ elif len(elts) == 2: v = elts[1]
+ else: self.error(str(self.data),self.ERROR_INFO_STRING)
+ info[elts[0]] = self.parse_formatdata(elts[0], v, self.vcf._info, line)
+ return info
+
+ property format:
+ def __get__(self):
+ return self.data[8].split(':')
+
+ def __getitem__(self, key):
+
+ # parse sample columns
+ values = self.data[self.vcf._sample2column[key]].split(':')
+ alt = self.alt
+ format = self.format
+
+ if len(values) > len(format):
+ self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))
+
+ result = {}
+ for idx in range(len(format)):
+ expected = self.vcf.get_expected(format[idx], self.vcf._format, alt)
+ if idx < len(values): value = values[idx]
+ else:
+ if expected == -1: value = "."
+ else: value = ",".join(["."]*expected)
+
+ result[format[idx]] = self.vcf.parse_formatdata(format[idx], value, self.vcf._format, line)
+ if expected != -1 and len(result[format[idx]]) != expected:
+ self.error(str(self.data),self.BAD_NUMBER_OF_PARAMETERS,
+ "id=%s, expected %s parameters, got %s" % (format[idx],expected,result[format[idx]]))
+ if len(result[format[idx]] ) < expected: result[format[idx]] += [result[format[idx]][-1]]*(expected-len(result[format[idx]]))
+ result[format[idx]] = result[format[idx]][:expected]
+
+ return result
+
+ def __str__(self):
+ return str(self.data)
+
+class VCF:
+
+ # types
+ NT_UNKNOWN = 0
+ NT_NUMBER = 1
+ NT_ALLELES = 2
+ NT_NR_ALLELES = 3
+ NT_GENOTYPES = 4
+ NT_PHASED_GENOTYPES = 5
+
+ _errors = { 0:"UNKNOWN_FORMAT_STRING:Unknown file format identifier",
+ 1:"BADLY_FORMATTED_FORMAT_STRING:Formatting error in the format string",
+ 2:"BADLY_FORMATTED_HEADING:Did not find 9 required headings (CHROM, POS, ..., FORMAT) %s",
+ 3:"BAD_NUMBER_OF_COLUMNS:Wrong number of columns found (%s)",
+ 4:"POS_NOT_NUMERICAL:Position column is not numerical",
+ 5:"UNKNOWN_CHAR_IN_REF:Unknown character in reference field",
+ 6:"V33_BAD_REF:Reference should be single-character in v3.3 VCF",
+ 7:"V33_BAD_ALLELE:Cannot interpret allele for v3.3 VCF",
+ 8:"POS_NOT_POSITIVE:Position field must be >0",
+ 9:"QUAL_NOT_NUMERICAL:Quality field must be numerical, or '.'",
+ 10:"ERROR_INFO_STRING:Error while parsing info field",
+ 11:"ERROR_UNKNOWN_KEY:Unknown key (%s) found in formatted field (info; format; or filter)",
+ 12:"ERROR_FORMAT_NOT_NUMERICAL:Expected integer or float in formatted field; got %s",
+ 13:"ERROR_FORMAT_NOT_CHAR:Eexpected character in formatted field; got string",
+ 14:"FILTER_NOT_DEFINED:Identifier (%s) in filter found which was not defined in header",
+ 15:"FORMAT_NOT_DEFINED:Identifier (%s) in format found which was not defined in header",
+ 16:"BAD_NUMBER_OF_VALUES:Found too many of values in sample column (%s)",
+ 17:"BAD_NUMBER_OF_PARAMETERS:Found unexpected number of parameters (%s)",
+ 18:"BAD_GENOTYPE:Cannot parse genotype (%s)",
+ 19:"V40_BAD_ALLELE:Bad allele found for v4.0 VCF (%s)",
+ 20:"MISSING_REF:Reference allele missing",
+ 21:"V33_UNMATCHED_DELETION:Deleted sequence does not match reference (%s)",
+ 22:"V40_MISSING_ANGLE_BRACKETS:Format definition is not deliminted by angular brackets",
+ 23:"FORMAT_MISSING_QUOTES:Description field in format definition is not surrounded by quotes",
+ 24:"V40_FORMAT_MUST_HAVE_NAMED_FIELDS:Fields in v4.0 VCF format definition must have named fields",
+ 25:"HEADING_NOT_SEPARATED_BY_TABS:Heading line appears separated by spaces, not tabs",
+ 26:"WRONG_REF:Wrong reference %s",
+ 27:"ERROR_TRAILING_DATA:Numerical field ('%s') has semicolon-separated trailing data",
+ 28:"BAD_CHR_TAG:Error calculating chr tag for %s",
+ 29:"ZERO_LENGTH_ALLELE:Found zero-length allele",
+ 30:"MISSING_INDEL_ALLELE_REF_BASE:Indel alleles must begin with single reference base"
+ }
+
+ # tag-value pairs; tags are not unique; does not include fileformat, INFO, FILTER or FORMAT fields
+ _header = []
+
+ # version number; 33=v3.3; 40=v4.0
+ _version = 40
+
+ # info, filter and format data
+ _info = {}
+ _filter = {}
+ _format = {}
+
+ # header; and required columns
+ _required = ["CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO","FORMAT"]
+ _samples = []
+
+ # control behaviour
+ _ignored_errors = set([11]) # ERROR_UNKNOWN_KEY
+ _warn_errors = set([])
+ _leftalign = False
+
+ # reference sequence
+ _reference = None
+
+ # regions to include; None includes everything
+ _regions = None
+
+ # statefull stuff
+ _lineno = -1
+ _line = None
+ _lines = None
+
+ def __init__(self, _copy=None, reference=None, regions=None, lines=None, leftalign=False):
+ # make error identifiers accessible by name
+ for id in self._errors.keys(): self.__dict__[self._errors[id].split(':')[0]] = id
+ if _copy != None:
+ self._leftalign = _copy._leftalign
+ self._header = _copy._header[:]
+ self._version = _copy._version
+ self._info = copy.deepcopy(_copy._info)
+ self._filter = copy.deepcopy(_copy._filter)
+ self._format = copy.deepcopy(_copy._format)
+ self._samples = _copy._samples[:]
+ self._sample2column = copy.deepcopy(_copy._sample2column)
+ self._ignored_errors = copy.deepcopy(_copy._ignored_errors)
+ self._warn_errors = copy.deepcopy(_copy._warn_errors)
+ self._reference = _copy._reference
+ self._regions = _copy._regions
+ if reference: self._reference = reference
+ if regions: self._regions = regions
+ if leftalign: self._leftalign = leftalign
+ self._lines = lines
+
+ def error(self,line,error,opt=None):
+ if error in self._ignored_errors: return
+ errorlabel, errorstring = self._errors[error].split(':')
+ if opt: errorstring = errorstring % opt
+ errwarn = ["Error","Warning"][error in self._warn_errors]
+ sys.stderr.write("Line %s: '%s'\n%s %s: %s\n" % (self._lineno,line,errwarn,errorlabel,errorstring))
+ if error in self._warn_errors: return
+ raise ValueError(errorstring)
+
+ def parse_format(self,line,format,filter=False):
+ if self._version == 40:
+ if not format.startswith('<'):
+ self.error(line,self.V40_MISSING_ANGLE_BRACKETS)
+ format = "<"+format
+ if not format.endswith('>'):
+ self.error(line,self.V40_MISSING_ANGLE_BRACKETS)
+ format += ">"
+ format = format[1:-1]
+ data = {'id':None,'number':None,'type':None,'descr':None}
+ idx = 0
+ while len(format.strip())>0:
+ elts = format.strip().split(',')
+ first, rest = elts[0], ','.join(elts[1:])
+ if first.find('=') == -1 or (first.find('"')>=0 and first.find('=') > first.find('"')):
+ if self._version == 40: self.error(line,self.V40_FORMAT_MUST_HAVE_NAMED_FIELDS)
+ if idx == 4: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ first = ["ID=","Number=","Type=","Description="][idx] + first
+ if first.startswith('ID='): data['id'] = first.split('=')[1]
+ elif first.startswith('Number='): data['number'] = first.split('=')[1]
+ elif first.startswith('Type='): data['type'] = first.split('=')[1]
+ elif first.startswith('Description='):
+ elts = format.split('"')
+ if len(elts)<3:
+ self.error(line,self.FORMAT_MISSING_QUOTES)
+ elts = first.split('=') + [rest]
+ data['descr'] = elts[1]
+ rest = '"'.join(elts[2:])
+ if rest.startswith(','): rest = rest[1:]
+ else:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ format = rest
+ idx += 1
+ if filter and idx==1: idx=3 # skip number and type fields for FILTER format strings
+ if not data['id']: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ if not data['descr']:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ data['descr'] = '<none>'
+ if not data['type'] and not data['number']:
+ # fine, ##filter format
+ return FORMAT(data['id'],self.NT_NUMBER,0,"Flag",data['descr'],'.')
+ if not data['type'] in ["Integer","Float","Character","String","Flag"]:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ # I would like a missing-value field, but it isn't there
+ if data['type'] in ['Integer','Float']: data['missing'] = None # Do NOT use arbitrary int/float as missing value
+ else: data['missing'] = '.'
+ if not data['number']: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ try:
+ n = int(data['number'])
+ t = self.NT_NUMBER
+ except ValueError:
+ n = -1
+ if data['number'] == '.': t = self.NT_UNKNOWN
+ elif data['number'] == '#alleles': t = self.NT_ALLELES
+ elif data['number'] == '#nonref_alleles': t = self.NT_NR_ALLELES
+ elif data['number'] == '#genotypes': t = self.NT_GENOTYPES
+ elif data['number'] == '#phased_genotypes': t = self.NT_PHASED_GENOTYPES
+ else:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ return FORMAT(data['id'],t,n,data['type'],data['descr'],data['missing'])
+
+
+ def format_format( self, fmt, filter=False ):
+ values = [('ID',fmt.id)]
+ if fmt.number != None and not filter:
+ if fmt.numbertype == self.NT_UNKNOWN: nmb = "."
+ elif fmt.numbertype == self.NT_NUMBER: nmb = str(fmt.number)
+ elif fmt.numbertype == self.NT_ALLELES: nmb = "#alleles"
+ elif fmt.numbertype == self.NT_NR_ALLELES: nmb = "#nonref_alleles"
+ elif fmt.numbertype == self.NT_GENOTYPES: nmb = "#genotypes"
+ elif fmt.numbertype == self.NT_PHASED_GENOTYPES: nmb = "#phased_genotypes"
+ else:
+ raise ValueError("Unknown number type encountered: %s" % fmt.numbertype)
+ values.append( ('Number',nmb) )
+ values.append( ('Type', fmt.type) )
+ values.append( ('Description', '"' + fmt.description + '"') )
+ if self._version == 33:
+ format = ",".join(v for k,v in values)
+ else:
+ format = "<" + (",".join( "%s=%s" % (k,v) for (k,v) in values )) + ">"
+ return format
+
+ def get_expected(self, format, formatdict, alt):
+ fmt = formatdict[format]
+ if fmt.numbertype == self.NT_UNKNOWN: return -1
+ if fmt.numbertype == self.NT_NUMBER: return fmt.number
+ if fmt.numbertype == self.NT_ALLELES: return len(alt)+1
+ if fmt.numbertype == self.NT_NR_ALLELES: return len(alt)
+ if fmt.numbertype == self.NT_GENOTYPES: return ((len(alt)+1)*(len(alt)+2)) // 2
+ if fmt.numbertype == self.NT_PHASED_GENOTYPES: return (len(alt)+1)*(len(alt)+1)
+ return 0
+
+
+ def _add_definition(self, formatdict, key, data, line ):
+ if key in formatdict: return
+ self.error(line,self.ERROR_UNKNOWN_KEY,key)
+ if data == None:
+ formatdict[key] = FORMAT(key,self.NT_NUMBER,0,"Flag","(Undefined tag)",".")
+ return
+ if data == []: data = [""] # unsure what type -- say string
+ if type(data[0]) == type(0.0):
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"Float","(Undefined tag)",None)
+ return
+ if type(data[0]) == type(0):
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"Integer","(Undefined tag)",None)
+ return
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"String","(Undefined tag)",".")
+
+
+ # todo: trim trailing missing values
+ def format_formatdata( self, data, format, key=True, value=True, separator=":" ):
+ output, sdata = [], []
+ if type(data) == type([]): # for FORMAT field, make data with dummy values
+ d = {}
+ for k in data: d[k] = []
+ data = d
+ # convert missing values; and silently add definitions if required
+ for k in data:
+ self._add_definition( format, k, data[k], "(output)" )
+ for idx,v in enumerate(data[k]):
+ if v == format[k].missingvalue: data[k][idx] = "."
+ # make sure GT comes first; and ensure fixed ordering; also convert GT data back to string
+ for k in data:
+ if k != 'GT': sdata.append( (k,data[k]) )
+ sdata.sort()
+ if 'GT' in data:
+ sdata = [('GT',map(self.convertGTback,data['GT']))] + sdata
+ for k,v in sdata:
+ if v == []: v = None
+ if key and value:
+ if v != None: output.append( k+"="+','.join(map(str,v)) )
+ else: output.append( k )
+ elif key: output.append(k)
+ elif value:
+ if v != None: output.append( ','.join(map(str,v)) )
+ else: output.append( "." ) # should not happen
+ # snip off trailing missing data
+ while len(output) > 1:
+ last = output[-1].replace(',','').replace('.','')
+ if len(last)>0: break
+ output = output[:-1]
+ return separator.join(output)
+
+
+ def enter_default_format(self):
+ for f in [FORMAT('GT',self.NT_NUMBER,1,'String','Genotype','.'),
+ FORMAT('GQ',self.NT_NUMBER,1,'Integer','Genotype Quality',-1),
+ FORMAT('DP',self.NT_NUMBER,1,'Integer','Read depth at this position for this sample',-1),
+ FORMAT('HQ',self.NT_UNKNOWN,-1,'Integer','Haplotype Quality',-1), # unknown number, since may be haploid
+ FORMAT('FT',self.NT_NUMBER,1,'String','Sample Genotype Filter','.')]:
+ if f.id not in self._format:
+ self._format[f.id] = f
+
+ def parse_header( self, line ):
+ assert line.startswith('##')
+ elts = line[2:].split('=')
+ key = elts[0].strip()
+ value = '='.join(elts[1:]).strip()
+ if key == "fileformat":
+ if value == "VCFv3.3":
+ self._version = 33
+ elif value == "VCFv4.0":
+ self._version = 40
+ elif value == "VCFv4.1":
+ # AH - for testing
+ self._version = 40
+ else:
+ self.error(line,self.UNKNOWN_FORMAT_STRING)
+ elif key == "INFO":
+ f = self.parse_format(line, value)
+ self._info[ f.id ] = f
+ elif key == "FILTER":
+ f = self.parse_format(line, value, filter=True)
+ self._filter[ f.id ] = f
+ elif key == "FORMAT":
+ f = self.parse_format(line, value)
+ self._format[ f.id ] = f
+ else:
+ # keep other keys in the header field
+ self._header.append( (key,value) )
+
+
+ def write_header( self, stream ):
+ stream.write("##fileformat=VCFv%s.%s\n" % (self._version // 10, self._version % 10))
+ for key,value in self._header: stream.write("##%s=%s\n" % (key,value))
+ for var,label in [(self._info,"INFO"),(self._filter,"FILTER"),(self._format,"FORMAT")]:
+ for f in var.itervalues(): stream.write("##%s=%s\n" % (label,self.format_format(f,filter=(label=="FILTER"))))
+
+
+ def parse_heading( self, line ):
+ assert line.startswith('#')
+ assert not line.startswith('##')
+ headings = line[1:].split('\t')
+ if len(headings)==1 and len(line[1:].split()) >= 9:
+ self.error(line,self.HEADING_NOT_SEPARATED_BY_TABS)
+ headings = line[1:].split()
+
+ for i,s in enumerate(self._required):
+
+ if len(headings)<=i or headings[i] != s:
+
+ if len(headings) <= i:
+ err = "(%sth entry not found)" % (i+1)
+ else:
+ err = "(found %s, expected %s)" % (headings[i],s)
+
+ #self.error(line,self.BADLY_FORMATTED_HEADING,err)
+
+ # allow FORMAT column to be absent
+ if len(headings) == 8:
+ headings.append("FORMAT")
+ else:
+ self.error(line,self.BADLY_FORMATTED_HEADING,err)
+
+ self._samples = headings[9:]
+ self._sample2column = dict( [(y,x) for x,y in enumerate( self._samples ) ] )
+
+ def write_heading( self, stream ):
+ stream.write("#" + "\t".join(self._required + self._samples) + "\n")
+
+ def convertGT(self, GTstring):
+ if GTstring == ".": return ["."]
+ try:
+ gts = gtsRegEx.split(GTstring)
+ if len(gts) == 1: return [int(gts[0])]
+ if len(gts) != 2: raise ValueError()
+ if gts[0] == "." and gts[1] == ".": return [gts[0],GTstring[len(gts[0]):-len(gts[1])],gts[1]]
+ return [int(gts[0]),GTstring[len(gts[0]):-len(gts[1])],int(gts[1])]
+ except ValueError:
+ self.error(self._line,self.BAD_GENOTYPE,GTstring)
+ return [".","|","."]
+
+
+ def convertGTback(self, GTdata):
+ return ''.join(map(str,GTdata))
+
+ def parse_formatdata( self, key, value, formatdict, line ):
+ # To do: check that the right number of values is present
+ f = formatdict.get(key,None)
+ if f == None:
+ self._add_definition(formatdict, key, value, line )
+ f = formatdict[key]
+ if f.type == "Flag":
+ if value is not None: self.error(line,self.ERROR_FLAG_HAS_VALUE)
+ return []
+ values = value.split(',')
+ # deal with trailing data in some early VCF files
+ if f.type in ["Float","Integer"] and len(values)>0 and values[-1].find(';') > -1:
+ self.error(line,self.ERROR_TRAILING_DATA,values[-1])
+ values[-1] = values[-1].split(';')[0]
+ if f.type == "Integer":
+ for idx,v in enumerate(values):
+ try:
+ if v == ".": values[idx] = f.missingvalue
+ else: values[idx] = int(v)
+ except:
+ self.error(line,self.ERROR_FORMAT_NOT_NUMERICAL,values)
+ return [0] * len(values)
+ return values
+ elif f.type == "String":
+ self._line = line
+ if f.id == "GT": values = map( self.convertGT, values )
+ return values
+ elif f.type == "Character":
+ for v in values:
+ if len(v) != 1: self.error(line,self.ERROR_FORMAT_NOT_CHAR)
+ return values
+ elif f.type == "Float":
+ for idx,v in enumerate(values):
+ if v == ".": values[idx] = f.missingvalue
+ try: return map(float,values)
+ except:
+ self.error(line,self.ERROR_FORMAT_NOT_NUMERICAL,values)
+ return [0.0] * len(values)
+ else:
+ # can't happen
+ self.error(line,self.ERROR_INFO_STRING)
+
+
+ def inregion(self, chrom, pos):
+ if not self._regions: return True
+ for r in self._regions:
+ if r[0] == chrom and r[1] <= pos < r[2]: return True
+ return False
+
+
+ def parse_data( self, line, lineparse=False ):
+ cols = line.split('\t')
+ if len(cols) != len(self._samples)+9:
+ # gracefully deal with absent FORMAT column
+ if len(cols) == 8 and len(self._samples)==0:
+ cols.append("")
+ else:
+ self.error(line,
+ self.BAD_NUMBER_OF_COLUMNS,
+ "expected %s for %s samples (%s), got %s" % (len(self._samples)+9, len(self._samples), self._samples, len(cols)))
+
+ chrom = cols[0]
+
+ # get 0-based position
+ try: pos = int(cols[1])-1
+ except: self.error(line,self.POS_NOT_NUMERICAL)
+ if pos < 0: self.error(line,self.POS_NOT_POSITIVE)
+
+ # implement filtering
+ if not self.inregion(chrom,pos): return None
+
+ # end of first-pass parse for sortedVCF
+ if lineparse: return chrom, pos, line
+
+ id = cols[2]
+
+ ref = cols[3].upper()
+ if ref == ".":
+ self.error(line,self.MISSING_REF)
+ if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
+ else: ref = ""
+ else:
+ for c in ref:
+ if c not in "ACGTN": self.error(line,self.UNKNOWN_CHAR_IN_REF)
+ if "N" in ref: ref = get_sequence(chrom,pos,pos+len(ref),self._reference)
+
+ # make sure reference is sane
+ if self._reference:
+ left = max(0,pos-100)
+ faref_leftflank = get_sequence(chrom,left,pos+len(ref),self._reference)
+ faref = faref_leftflank[pos-left:]
+ if faref != ref: self.error(line,self.WRONG_REF,"(reference is %s, VCF says %s)" % (faref,ref))
+ ref = faref
+
+ # convert v3.3 to v4.0 alleles below
+ if cols[4] == ".": alt = []
+ else: alt = cols[4].upper().split(',')
+
+ if cols[5] == ".": qual = -1
+ else:
+ try: qual = float(cols[5])
+ except: self.error(line,self.QUAL_NOT_NUMERICAL)
+
+ # postpone checking that filters exist. Encode missing filter or no filtering as empty list
+ if cols[6] == "." or cols[6] == "PASS" or cols[6] == "0": filter = []
+ else: filter = cols[6].split(';')
+
+ # dictionary of keys, and list of values
+ info = {}
+ if cols[7] != ".":
+ for blurp in cols[7].split(';'):
+ elts = blurp.split('=')
+ if len(elts) == 1: v = None
+ elif len(elts) == 2: v = elts[1]
+ else: self.error(line,self.ERROR_INFO_STRING)
+ info[elts[0]] = self.parse_formatdata(elts[0], v, self._info, line)
+
+ # Gracefully deal with absent FORMAT column
+ if cols[8] == "": format = []
+ else: format = cols[8].split(':')
+
+ # check: all filters are defined
+ for f in filter:
+ if f not in self._filter: self.error(line,self.FILTER_NOT_DEFINED, f)
+
+ # check: format fields are defined
+ for f in format:
+ if f not in self._format: self.error(line,self.FORMAT_NOT_DEFINED, f)
+
+ # convert v3.3 alleles
+ if self._version == 33:
+ if len(ref) != 1: self.error(line,self.V33_BAD_REF)
+ newalts = []
+ have_deletions = False
+ for a in alt:
+ if len(a) == 1: a = a + ref[1:] # SNP; add trailing reference
+ elif a.startswith('I'): a = ref[0] + a[1:] + ref[1:] # insertion just beyond pos; add first and trailing reference
+ elif a.startswith('D'): # allow D<seq> and D<num>
+ have_deletions = True
+ try:
+ l = int(a[1:]) # throws ValueError if sequence
+ if len(ref) < l: # add to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[l:] # new deletion, deleting pos...pos+l
+ except ValueError:
+ s = a[1:]
+ if len(ref) < len(s): # add Ns to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ if not s.endswith(addns) and addns != 'N'*len(addns):
+ self.error(line,self.V33_UNMATCHED_DELETION,
+ "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[len(s):] # new deletion, deleting from pos
+ else:
+ self.error(line,self.V33_BAD_ALLELE)
+ newalts.append(a)
+ alt = newalts
+ # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ if have_deletions:
+ if pos == 0:
+ # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ ref += addn
+ alt = [allele+addn for allele in alt]
+ else:
+ addn = get_sequence(chrom,pos-1,pos,self._reference)
+ ref = addn + ref
+ alt = [addn + allele for allele in alt]
+ pos -= 1
+ else:
+ # format v4.0 -- just check for nucleotides
+ for allele in alt:
+ if not alleleRegEx.match(allele):
+ self.error(line,self.V40_BAD_ALLELE,allele)
+
+ # check for leading nucleotide in indel calls
+ for allele in alt:
+ if len(allele) != len(ref):
+ if len(allele) == 0: self.error(line,self.ZERO_LENGTH_ALLELE)
+ if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
+ self.error(line,self.MISSING_INDEL_ALLELE_REF_BASE)
+
+ # trim trailing bases in alleles
+ for i in range(1,min(len(ref),min(map(len,alt)))):
+ if len(set(allele[-1].upper() for allele in alt)) > 1 or ref[-1].upper() != alt[0][-1].upper():
+ break
+ ref, alt = ref[:-1], [allele[:-1] for allele in alt]
+
+ # left-align alleles, if a reference is available
+ if self._leftalign and self._reference:
+ while left < pos:
+ movable = True
+ for allele in alt:
+ if len(allele) > len(ref):
+ longest, shortest = allele, ref
+ else:
+ longest, shortest = ref, allele
+ if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ movable = False
+ if longest[-1].upper() != longest[len(shortest)-1].upper():
+ movable = False
+ if not movable:
+ break
+ ref = ref[:-1]
+ alt = [allele[:-1] for allele in alt]
+ if min(len(allele) for allele in alt) == 0 or len(ref) == 0:
+ ref = faref_leftflank[pos-left-1] + ref
+ alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
+ pos -= 1
+
+ # parse sample columns
+ samples = []
+ for sample in cols[9:]:
+ dict = {}
+ values = sample.split(':')
+ if len(values) > len(format):
+ self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))
+ for idx in range(len(format)):
+ expected = self.get_expected(format[idx], self._format, alt)
+ if idx < len(values): value = values[idx]
+ else:
+ if expected == -1: value = "."
+ else: value = ",".join(["."]*expected)
+ dict[format[idx]] = self.parse_formatdata(format[idx], value, self._format, line)
+ if expected != -1 and len(dict[format[idx]]) != expected:
+ self.error(line,self.BAD_NUMBER_OF_PARAMETERS,
+ "id=%s, expected %s parameters, got %s" % (format[idx],expected,dict[format[idx]]))
+ if len(dict[format[idx]] ) < expected: dict[format[idx]] += [dict[format[idx]][-1]]*(expected-len(dict[format[idx]]))
+ dict[format[idx]] = dict[format[idx]][:expected]
+ samples.append( dict )
+
+ # done
+ d = {'chrom':chrom,
+ 'pos':pos, # return 0-based position
+ 'id':id,
+ 'ref':ref,
+ 'alt':alt,
+ 'qual':qual,
+ 'filter':filter,
+ 'info':info,
+ 'format':format}
+ for key,value in zip(self._samples,samples):
+ d[key] = value
+
+ return d
+
+
+ def write_data(self, stream, data):
+ required = ['chrom','pos','id','ref','alt','qual','filter','info','format'] + self._samples
+ for k in required:
+ if k not in data: raise ValueError("Required key %s not found in data" % str(k))
+ if data['alt'] == []: alt = "."
+ else: alt = ",".join(data['alt'])
+ if data['filter'] == None: filter = "."
+ elif data['filter'] == []:
+ if self._version == 33: filter = "0"
+ else: filter = "PASS"
+ else: filter = ';'.join(data['filter'])
+ if data['qual'] == -1: qual = "."
+ else: qual = str(data['qual'])
+
+ output = [data['chrom'],
+ str(data['pos']+1), # change to 1-based position
+ data['id'],
+ data['ref'],
+ alt,
+ qual,
+ filter,
+ self.format_formatdata( data['info'], self._info, separator=";" ),
+ self.format_formatdata( data['format'], self._format, value=False ) ]
+
+ for s in self._samples:
+ output.append( self.format_formatdata( data[s], self._format, key=False ) )
+
+ stream.write( "\t".join(output) + "\n" )
+
+ def _parse_header(self, stream):
+ self._lineno = 0
+ for line in stream:
+ self._lineno += 1
+ if line.startswith('##'):
+ self.parse_header( line.strip() )
+ elif line.startswith('#'):
+ self.parse_heading( line.strip() )
+ self.enter_default_format()
+ else:
+ break
+ return line
+
+ def _parse(self, line, stream):
+ if len(line.strip()) > 0:
+ d = self.parse_data( line.strip() )
+ if d: yield d
+ for line in stream:
+ self._lineno += 1
+ if self._lines and self._lineno > self._lines: raise StopIteration
+ d = self.parse_data( line.strip() )
+ if d: yield d
+
+ ######################################################################################################
+ #
+ # API follows
+ #
+ ######################################################################################################
+
+ def getsamples(self):
+ """ List of samples in VCF file """
+ return self._samples
+
+ def setsamples(self,samples):
+ """ List of samples in VCF file """
+ self._samples = samples
+
+ def getheader(self):
+ """ List of header key-value pairs (strings) """
+ return self._header
+
+ def setheader(self,header):
+ """ List of header key-value pairs (strings) """
+ self._header = header
+
+ def getinfo(self):
+ """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ return self._info
+
+ def setinfo(self,info):
+ """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ self._info = info
+
+ def getformat(self):
+ """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ return self._format
+
+ def setformat(self,format):
+ """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ self._format = format
+
+ def getfilter(self):
+ """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ return self._filter
+
+ def setfilter(self,filter):
+ """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ self._filter = filter
+
+ def setversion(self, version):
+ if version != 33 and version != 40: raise ValueError("Can only handle v3.3 and v4.0 VCF files")
+ self._version = version
+
+ def setregions(self, regions):
+ self._regions = regions
+
+ def setreference(self, ref):
+ """ Provide a reference sequence; a Python class supporting a fetch(chromosome, start, end) method, e.g. PySam.FastaFile """
+ self._reference = ref
+
+ def ignoreerror(self, errorstring):
+ try: self._ignored_errors.add(self.__dict__[errorstring])
+ except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+
+ def warnerror(self, errorstring):
+ try: self._warn_errors.add(self.__dict__[errorstring])
+ except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+
+ def parse(self, stream):
+ """ Parse a stream of VCF-formatted lines. Initializes class instance and return generator """
+ last_line = self._parse_header(stream)
+ # now return a generator that does the actual work. In this way the pre-processing is done
+ # before the first piece of data is yielded
+ return self._parse(last_line, stream)
+
+ def write(self, stream, datagenerator):
+ """ Writes a VCF file to a stream, using a data generator (or list) """
+ self.write_header(stream)
+ self.write_heading(stream)
+ for data in datagenerator: self.write_data(stream,data)
+
+ def writeheader(self, stream):
+ """ Writes a VCF header """
+ self.write_header(stream)
+ self.write_heading(stream)
+
+ def compare_calls(self, pos1, ref1, alt1, pos2, ref2, alt2):
+ """ Utility function: compares two calls for equality """
+ # a variant should always be assigned to a unique position, one base before
+ # the leftmost position of the alignment gap. If this rule is implemented
+ # correctly, the two positions must be equal for the calls to be identical.
+ if pos1 != pos2: return False
+ # from both calls, trim rightmost bases when identical. Do this safely, i.e.
+ # only when the reference bases are not Ns
+ while len(ref1)>0 and len(alt1)>0 and ref1[-1] == alt1[-1]:
+ ref1 = ref1[:-1]
+ alt1 = alt1[:-1]
+ while len(ref2)>0 and len(alt2)>0 and ref2[-1] == alt2[-1]:
+ ref2 = ref2[:-1]
+ alt2 = alt2[:-1]
+ # now, the alternative alleles must be identical
+ return alt1 == alt2
+
+###########################################################################################################
+###########################################################################################################
+## API functions added by Andreas
+###########################################################################################################
+
+ def connect( self, filename ):
+ '''connect to tabix file.'''
+ self.tabixfile = pysam.Tabixfile( filename )
+ self._parse_header(self.tabixfile.header)
+
+ def fetch(self,
+ reference = None,
+ start = None,
+ end = None,
+ region = None ):
+ """ Parse a stream of VCF-formatted lines. Initializes class instance and return generator """
+
+ iter = self.tabixfile.fetch( reference, start, end, region, parser = pysam.asVCF() )
+ for x in iter:
+ yield VCFRecord( x, self )
+
+ def validate( self, record ):
+ '''validate vcf record.
+
+ returns a validated record.
+ '''
+
+ chrom, pos = record.chrom, record.pos
+
+ # check reference
+ ref = record.ref
+ if ref == ".":
+ self.error(str(record),self.MISSING_REF)
+ if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
+ else: ref = ""
+ else:
+ for c in ref:
+ if c not in "ACGTN": self.error(str(record),self.UNKNOWN_CHAR_IN_REF)
+ if "N" in ref: ref = get_sequence(chrom,
+ pos,
+ pos+len(ref),
+ self._reference)
+
+ # make sure reference is sane
+ if self._reference:
+ left = max(0,self.pos-100)
+ faref_leftflank = get_sequence(chrom,left,self.pos+len(ref),self._reference)
+ faref = faref_leftflank[pos-left:]
+ if faref != ref: self.error(line,self.WRONG_REF,"(reference is %s, VCF says %s)" % (faref,ref))
+ ref = faref
+
+ # check: format fields are defined
+ for f in record.format:
+ if f not in self._format: self.error(str(record),self.FORMAT_NOT_DEFINED, f)
+
+ # check: all filters are defined
+ for f in record.filter:
+ if f not in self._filter: self.error(str(record),self.FILTER_NOT_DEFINED, f)
+
+ # convert v3.3 alleles
+ if self._version == 33:
+ if len(ref) != 1: self.error(line,self.V33_BAD_REF)
+ newalts = []
+ have_deletions = False
+ for a in alt:
+ if len(a) == 1: a = a + ref[1:] # SNP; add trailing reference
+ elif a.startswith('I'): a = ref[0] + a[1:] + ref[1:] # insertion just beyond pos; add first and trailing reference
+ elif a.startswith('D'): # allow D<seq> and D<num>
+ have_deletions = True
+ try:
+ l = int(a[1:]) # throws ValueError if sequence
+ if len(ref) < l: # add to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[l:] # new deletion, deleting pos...pos+l
+ except ValueError:
+ s = a[1:]
+ if len(ref) < len(s): # add Ns to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ if not s.endswith(addns) and addns != 'N'*len(addns):
+ self.error(line,self.V33_UNMATCHED_DELETION,
+ "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[len(s):] # new deletion, deleting from pos
+ else:
+ self.error(line,self.V33_BAD_ALLELE)
+ newalts.append(a)
+ alt = newalts
+ # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ if have_deletions:
+ if pos == 0:
+ # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ ref += addn
+ alt = [allele+addn for allele in alt]
+ else:
+ addn = get_sequence(chrom,pos-1,pos,self._reference)
+ ref = addn + ref
+ alt = [addn + allele for allele in alt]
+ pos -= 1
+ else:
+ # format v4.0 -- just check for nucleotides
+ for allele in alt:
+ if not alleleRegEx.match(allele):
+ self.error(line,self.V40_BAD_ALLELE,allele)
+
+
+ # check for leading nucleotide in indel calls
+ for allele in alt:
+ if len(allele) != len(ref):
+ if len(allele) == 0: self.error(line,self.ZERO_LENGTH_ALLELE)
+ if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
+ self.error(line,self.MISSING_INDEL_ALLELE_REF_BASE)
+
+ # trim trailing bases in alleles
+ for i in range(1,min(len(ref),min(map(len,alt)))):
+ if len(set(allele[-1].upper() for allele in alt)) > 1 or ref[-1].upper() != alt[0][-1].upper():
+ break
+ ref, alt = ref[:-1], [allele[:-1] for allele in alt]
+
+ # left-align alleles, if a reference is available
+ if self._leftalign and self._reference:
+ while left < pos:
+ movable = True
+ for allele in alt:
+ if len(allele) > len(ref):
+ longest, shortest = allele, ref
+ else:
+ longest, shortest = ref, allele
+ if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ movable = False
+ if longest[-1].upper() != longest[len(shortest)-1].upper():
+ movable = False
+ if not movable:
+ break
+ ref = ref[:-1]
+ alt = [allele[:-1] for allele in alt]
+ if min(len(allele) for allele in alt) == 0 or len(ref) == 0:
+ ref = faref_leftflank[pos-left-1] + ref
+ alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
+ pos -= 1
+
+
+
+
from ctabix import *
import csamtools
import ctabix
+from cvcf import *
+import cvcf
import Pileup
import sys
import os
self.parsers = parsers
self.stderr = []
- def __call__(self,*args, **kwargs):
- '''execute the samtools command
+ def __call__(self, *args, **kwargs):
+ '''execute a samtools command
'''
retval, stderr, stdout = csamtools._samtools_dispatch( self.dispatch, args )
if retval: raise SamtoolsError( "\n".join( stderr ) )
# for example: [sam_header_read2] 2 sequences loaded.
# Ignore messages like these
stderr = [ x for x in stderr \
- if not x.startswith( "[sam_header_read2]" ) or \
- x.startswith("[bam_index_load]") or \
- x.startswith("[bam_sort_core]") or \
- x.startswith("[samopen] SAM header is present")
+ if not (x.startswith( "[sam_header_read2]" ) or \
+ x.startswith("[bam_index_load]") or \
+ x.startswith("[bam_sort_core]") or \
+ x.startswith("[samopen] SAM header is present") )
]
if stderr: raise SamtoolsError( "\n".join( stderr ) )
globals()[key] = SamtoolsDispatcher(cmd, parser)
# hack to export all the symbols from csamtools
-__all__ = csamtools.__all__ + \
+__all__ = \
+ csamtools.__all__ + \
ctabix.__all__ + \
+ cvcf.__all__ +\
[ "SamtoolsError", "SamtoolsDispatcher" ] + list(SAMTOOLS_DISPATCH) +\
- ["Pileup",]
+ ["Pileup" ]
from version import __version__, __samtools_version__
--- /dev/null
+/* Generated by Cython 0.13 on Tue Jun 7 17:24:36 2011 */
+
+#define PY_SSIZE_T_CLEAN
+#include "Python.h"
+#ifndef Py_PYTHON_H
+ #error Python headers needed to compile C extensions, please install development version of Python.
+#else
+
+#include <stddef.h> /* For offsetof */
+#ifndef offsetof
+#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
+#endif
+
+#if !defined(WIN32) && !defined(MS_WINDOWS)
+ #ifndef __stdcall
+ #define __stdcall
+ #endif
+ #ifndef __cdecl
+ #define __cdecl
+ #endif
+ #ifndef __fastcall
+ #define __fastcall
+ #endif
+#endif
+
+#ifndef DL_IMPORT
+ #define DL_IMPORT(t) t
+#endif
+#ifndef DL_EXPORT
+ #define DL_EXPORT(t) t
+#endif
+
+#ifndef PY_LONG_LONG
+ #define PY_LONG_LONG LONG_LONG
+#endif
+
+#if PY_VERSION_HEX < 0x02040000
+ #define METH_COEXIST 0
+ #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
+ #define PyDict_Contains(d,o) PySequence_Contains(d,o)
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ typedef int Py_ssize_t;
+ #define PY_SSIZE_T_MAX INT_MAX
+ #define PY_SSIZE_T_MIN INT_MIN
+ #define PY_FORMAT_SIZE_T ""
+ #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
+ #define PyInt_AsSsize_t(o) PyInt_AsLong(o)
+ #define PyNumber_Index(o) PyNumber_Int(o)
+ #define PyIndex_Check(o) PyNumber_Check(o)
+ #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
+ #define Py_TYPE(ob) (((PyObject*)(ob))->ob_type)
+ #define Py_SIZE(ob) (((PyVarObject*)(ob))->ob_size)
+ #define PyVarObject_HEAD_INIT(type, size) \
+ PyObject_HEAD_INIT(type) size,
+ #define PyType_Modified(t)
+
+ typedef struct {
+ void *buf;
+ PyObject *obj;
+ Py_ssize_t len;
+ Py_ssize_t itemsize;
+ int readonly;
+ int ndim;
+ char *format;
+ Py_ssize_t *shape;
+ Py_ssize_t *strides;
+ Py_ssize_t *suboffsets;
+ void *internal;
+ } Py_buffer;
+
+ #define PyBUF_SIMPLE 0
+ #define PyBUF_WRITABLE 0x0001
+ #define PyBUF_FORMAT 0x0004
+ #define PyBUF_ND 0x0008
+ #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
+ #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
+ #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
+ #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
+ #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
+
+#endif
+
+#if PY_MAJOR_VERSION < 3
+ #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
+#else
+ #define __Pyx_BUILTIN_MODULE_NAME "builtins"
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define Py_TPFLAGS_CHECKTYPES 0
+ #define Py_TPFLAGS_HAVE_INDEX 0
+#endif
+
+#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
+ #define Py_TPFLAGS_HAVE_NEWBUFFER 0
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBaseString_Type PyUnicode_Type
+ #define PyStringObject PyUnicodeObject
+ #define PyString_Type PyUnicode_Type
+ #define PyString_Check PyUnicode_Check
+ #define PyString_CheckExact PyUnicode_CheckExact
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define PyBytesObject PyStringObject
+ #define PyBytes_Type PyString_Type
+ #define PyBytes_Check PyString_Check
+ #define PyBytes_CheckExact PyString_CheckExact
+ #define PyBytes_FromString PyString_FromString
+ #define PyBytes_FromStringAndSize PyString_FromStringAndSize
+ #define PyBytes_FromFormat PyString_FromFormat
+ #define PyBytes_DecodeEscape PyString_DecodeEscape
+ #define PyBytes_AsString PyString_AsString
+ #define PyBytes_AsStringAndSize PyString_AsStringAndSize
+ #define PyBytes_Size PyString_Size
+ #define PyBytes_AS_STRING PyString_AS_STRING
+ #define PyBytes_GET_SIZE PyString_GET_SIZE
+ #define PyBytes_Repr PyString_Repr
+ #define PyBytes_Concat PyString_Concat
+ #define PyBytes_ConcatAndDel PyString_ConcatAndDel
+ #define PySet_Check(obj) PyObject_TypeCheck(obj, &PySet_Type)
+ #define PyFrozenSet_Check(obj) PyObject_TypeCheck(obj, &PyFrozenSet_Type)
+#endif
+
+#ifndef PySet_CheckExact
+# define PySet_CheckExact(obj) (Py_TYPE(obj) == &PySet_Type)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyInt_Type PyLong_Type
+ #define PyInt_Check(op) PyLong_Check(op)
+ #define PyInt_CheckExact(op) PyLong_CheckExact(op)
+ #define PyInt_FromString PyLong_FromString
+ #define PyInt_FromUnicode PyLong_FromUnicode
+ #define PyInt_FromLong PyLong_FromLong
+ #define PyInt_FromSize_t PyLong_FromSize_t
+ #define PyInt_FromSsize_t PyLong_FromSsize_t
+ #define PyInt_AsLong PyLong_AsLong
+ #define PyInt_AS_LONG PyLong_AS_LONG
+ #define PyInt_AsSsize_t PyLong_AsSsize_t
+ #define PyInt_AsUnsignedLongMask PyLong_AsUnsignedLongMask
+ #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBoolObject PyLongObject
+#endif
+
+
+#if PY_MAJOR_VERSION >= 3
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_TrueDivide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceTrueDivide(x,y)
+#else
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_Divide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceDivide(x,y)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),((char *)(n)))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),((char *)(n)))
+#else
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),(n))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),(n))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_NAMESTR(n) ((char *)(n))
+ #define __Pyx_DOCSTR(n) ((char *)(n))
+#else
+ #define __Pyx_NAMESTR(n) (n)
+ #define __Pyx_DOCSTR(n) (n)
+#endif
+
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+
+#if defined(WIN32) || defined(MS_WINDOWS)
+#define _USE_MATH_DEFINES
+#endif
+#include <math.h>
+#define __PYX_HAVE_API__csamtools
+#include "string.h"
+#include "stdlib.h"
+#include "math.h"
+#include "stdio.h"
+#include "ctype.h"
+#include "unistd.h"
+#include "fileobject.h"
+#include "razf.h"
+#include "stdint.h"
+#include "bam.h"
+#include "sam.h"
+#include "glf.h"
+#include "bam_maqcns.h"
+#include "faidx.h"
+#include "pysam_util.h"
+#include "pythread.h"
+
+/* inline attribute */
+#ifndef CYTHON_INLINE
+ #if defined(__GNUC__)
+ #define CYTHON_INLINE __inline__
+ #elif defined(_MSC_VER)
+ #define CYTHON_INLINE __inline
+ #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+ #define CYTHON_INLINE inline
+ #else
+ #define CYTHON_INLINE
+ #endif
+#endif
+
+/* unused attribute */
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+# if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+# elif defined(__ICC) || defined(__INTEL_COMPILER)
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+#endif
+
+typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
+
+
+/* Type Conversion Predeclarations */
+
+#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
+#define __Pyx_PyBytes_AsUString(s) ((unsigned char*) PyBytes_AsString(s))
+
+#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
+
+#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
+
+
+#ifdef __GNUC__
+/* Test for GCC > 2.95 */
+#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95))
+#define likely(x) __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* __GNUC__ > 2 ... */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ > 2 ... */
+#else /* __GNUC__ */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+
+static PyObject *__pyx_m;
+static PyObject *__pyx_b;
+static PyObject *__pyx_empty_tuple;
+static PyObject *__pyx_empty_bytes;
+static int __pyx_lineno;
+static int __pyx_clineno = 0;
+static const char * __pyx_cfilenm= __FILE__;
+static const char *__pyx_filename;
+
+
+static const char *__pyx_f[] = {
+ "csamtools.pyx",
+ "csamtools.pxd",
+ "bool.pxd",
+};
+
+/* Type declarations */
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":388
+ * counter[0] += 1;
+ *
+ * ctypedef struct MateData: # <<<<<<<<<<<<<<
+ * char * name
+ * bam1_t * mate
+ */
+
+typedef struct {
+ char *name;
+ bam1_t *mate;
+ uint32_t flag;
+} __pyx_t_9csamtools_MateData;
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1478
+ * ##-------------------------------------------------------------------
+ * ##-------------------------------------------------------------------
+ * ctypedef struct __iterdata: # <<<<<<<<<<<<<<
+ * samfile_t * samfile
+ * bam_iter_t iter
+ */
+
+typedef struct {
+ samfile_t *samfile;
+ bam_iter_t iter;
+ faidx_t *fastafile;
+ int tid;
+ char *seq;
+ int seq_len;
+} __pyx_t_9csamtools___iterdata;
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1655
+ * bam_plp_set_mask( self.pileup_iter, self.mask )
+ *
+ * cdef setupIteratorData( self, # <<<<<<<<<<<<<<
+ * int tid,
+ * int start,
+ */
+
+struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData {
+ int __pyx_n;
+ int reopen;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3192
+ * bam_maqindel_ret_destroy(self._r)
+ *
+ * cdef class IndelCallerBase: # <<<<<<<<<<<<<<
+ * '''Base class for SNP callers.
+ *
+ */
+
+struct __pyx_obj_9csamtools_IndelCallerBase {
+ PyObject_HEAD
+ bam_maqindel_opt_t *options;
+ struct __pyx_obj_9csamtools_IteratorColumn *iter;
+ int cap_mapQ;
+ int max_depth;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3330
+ * return self._call()
+ *
+ * cdef class IteratorIndelCalls( IndelCallerBase ): # <<<<<<<<<<<<<<
+ * """*(IteratorColumn iterator)*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorIndelCalls {
+ struct __pyx_obj_9csamtools_IndelCallerBase __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":244
+ * ## Public methods
+ * ######################################################################
+ * cdef class Fastafile: # <<<<<<<<<<<<<<
+ * '''*(filename)*
+ *
+ */
+
+struct __pyx_obj_9csamtools_Fastafile {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_9csamtools_Fastafile *__pyx_vtab;
+ char *_filename;
+ faidx_t *fastafile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3103
+ * return call
+ *
+ * cdef class IndelCall: # <<<<<<<<<<<<<<
+ * '''the results of an indel call.'''
+ * cdef int _tid
+ */
+
+struct __pyx_obj_9csamtools_IndelCall {
+ PyObject_HEAD
+ int _tid;
+ int _pos;
+ int _coverage;
+ int _rms_mapping_quality;
+ bam_maqindel_ret_t *_r;
+};
+
+/* "pysam/csamtools.pxd":388
+ * cdef bam1_t * _delegate
+ *
+ * cdef class Samfile: # <<<<<<<<<<<<<<
+ * cdef char * _filename
+ * # pointer to samfile
+ */
+
+struct __pyx_obj_9csamtools_Samfile {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_9csamtools_Samfile *__pyx_vtab;
+ char *_filename;
+ samfile_t *samfile;
+ bam_index_t *index;
+ int isbam;
+ int isremote;
+ bam1_t *b;
+ char *mode;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3287
+ * return call
+ *
+ * cdef class IndelCaller( IndelCallerBase ): # <<<<<<<<<<<<<<
+ * '''*(IteratorColumn iterator_column )*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IndelCaller {
+ struct __pyx_obj_9csamtools_IndelCallerBase __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":91
+ * return dest
+ *
+ * cdef class PileupRead # <<<<<<<<<<<<<<
+ * cdef makePileupRead( bam_pileup1_t * src ):
+ * '''fill a PileupRead object from a bam_pileup1_t * object.'''
+ */
+
+struct __pyx_obj_9csamtools_PileupRead {
+ PyObject_HEAD
+ struct __pyx_obj_9csamtools_AlignedRead *_alignment;
+ int32_t _qpos;
+ int _indel;
+ int _level;
+ uint32_t _is_del;
+ uint32_t _is_head;
+ uint32_t _is_tail;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2816
+ * return retval, out_stderr, out_stdout
+ *
+ * cdef class SNPCall: # <<<<<<<<<<<<<<
+ * '''the results of a SNP call.'''
+ * cdef int _tid
+ */
+
+struct __pyx_obj_9csamtools_SNPCall {
+ PyObject_HEAD
+ int _tid;
+ int _pos;
+ char _reference_base;
+ char _genotype;
+ int _consensus_quality;
+ int _snp_quality;
+ int _rms_mapping_quality;
+ int _coverage;
+};
+
+/* "pysam/csamtools.pxd":383
+ *
+ * # need to declare all C fields and methods here
+ * cdef class AlignedRead: # <<<<<<<<<<<<<<
+ *
+ * # object that this AlignedRead represents
+ */
+
+struct __pyx_obj_9csamtools_AlignedRead {
+ PyObject_HEAD
+ bam1_t *_delegate;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1542
+ * return ret
+ *
+ * cdef class IteratorColumn: # <<<<<<<<<<<<<<
+ * '''abstract base class for iterators over columns.
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorColumn {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_9csamtools_IteratorColumn *__pyx_vtab;
+ struct __pyx_obj_9csamtools_IteratorRowRegion *iter;
+ int tid;
+ int pos;
+ int n_plp;
+ int mask;
+ const bam_pileup1_t * plp;
+ bam_plp_t pileup_iter;
+ __pyx_t_9csamtools___iterdata iterdata;
+ struct __pyx_obj_9csamtools_Samfile *samfile;
+ struct __pyx_obj_9csamtools_Fastafile *fastafile;
+ PyObject *stepper;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1712
+ * self.iterdata.seq = NULL
+ *
+ * cdef class IteratorColumnRegion(IteratorColumn): # <<<<<<<<<<<<<<
+ * '''iterates over a region only.
+ * '''
+ */
+
+struct __pyx_obj_9csamtools_IteratorColumnRegion {
+ struct __pyx_obj_9csamtools_IteratorColumn __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1187
+ * ##-------------------------------------------------------------------
+ * ##-------------------------------------------------------------------
+ * cdef class IteratorRow: # <<<<<<<<<<<<<<
+ * '''abstract base class for iterators over mapped reads.
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorRow {
+ PyObject_HEAD
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1356
+ * if self.owns_samfile: samclose( self.fp )
+ *
+ * cdef class IteratorRowAllRefs(IteratorRow): # <<<<<<<<<<<<<<
+ * """iterates over all mapped reads by chaining iterators over each reference
+ * """
+ */
+
+struct __pyx_obj_9csamtools_IteratorRowAllRefs {
+ struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
+ struct __pyx_obj_9csamtools_Samfile *samfile;
+ int tid;
+ struct __pyx_obj_9csamtools_IteratorRowRegion *rowiter;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1206
+ * pass
+ *
+ * cdef class IteratorRowRegion(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile, int tid, int beg, int end, int reopen = True )*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorRowRegion {
+ struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
+ struct __pyx_vtabstruct_9csamtools_IteratorRowRegion *__pyx_vtab;
+ bam_iter_t iter;
+ bam1_t *b;
+ int retval;
+ struct __pyx_obj_9csamtools_Samfile *samfile;
+ samfile_t *fp;
+ int owns_samfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1741
+ * self.n_plp )
+ *
+ * cdef class IteratorColumnAllRefs(IteratorColumn): # <<<<<<<<<<<<<<
+ * """iterates over all columns by chaining iterators over each reference
+ * """
+ */
+
+struct __pyx_obj_9csamtools_IteratorColumnAllRefs {
+ struct __pyx_obj_9csamtools_IteratorColumn __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1402
+ * raise StopIteration
+ *
+ * cdef class IteratorRowSelection(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile)*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorRowSelection {
+ struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
+ struct __pyx_vtabstruct_9csamtools_IteratorRowSelection *__pyx_vtab;
+ bam1_t *b;
+ int current_pos;
+ samfile_t *fp;
+ PyObject *positions;
+ int owns_samfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2873
+ *
+ *
+ * cdef class SNPCallerBase: # <<<<<<<<<<<<<<
+ * '''Base class for SNP callers.
+ *
+ */
+
+struct __pyx_obj_9csamtools_SNPCallerBase {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_9csamtools_SNPCallerBase *__pyx_vtab;
+ bam_maqcns_t *c;
+ struct __pyx_obj_9csamtools_IteratorColumn *iter;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3021
+ * return call
+ *
+ * cdef class SNPCaller( SNPCallerBase ): # <<<<<<<<<<<<<<
+ * '''*(IteratorColumn iterator_column )*
+ *
+ */
+
+struct __pyx_obj_9csamtools_SNPCaller {
+ struct __pyx_obj_9csamtools_SNPCallerBase __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2946
+ * sys.stdout.flush()
+ *
+ * cdef class IteratorSNPCalls( SNPCallerBase ): # <<<<<<<<<<<<<<
+ * """*(IteratorColumn iterator)*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorSNPCalls {
+ struct __pyx_obj_9csamtools_SNPCallerBase __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1292
+ * if self.owns_samfile: samclose( self.fp )
+ *
+ * cdef class IteratorRowAll(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile, int reopen = True)*
+ *
+ */
+
+struct __pyx_obj_9csamtools_IteratorRowAll {
+ struct __pyx_obj_9csamtools_IteratorRow __pyx_base;
+ struct __pyx_vtabstruct_9csamtools_IteratorRowAll *__pyx_vtab;
+ bam1_t *b;
+ samfile_t *fp;
+ int owns_samfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3370
+ *
+ *
+ * cdef class IndexedReads: # <<<<<<<<<<<<<<
+ * """index a bamfile by read.
+ *
+ */
+
+struct __pyx_obj_9csamtools_IndexedReads {
+ PyObject_HEAD
+ struct __pyx_obj_9csamtools_Samfile *samfile;
+ samfile_t *fp;
+ PyObject *index;
+ int owns_samfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":82
+ * return dest
+ *
+ * cdef class PileupProxy # <<<<<<<<<<<<<<
+ * cdef makePileupProxy( bam_pileup1_t * plp, int tid, int pos, int n ):
+ * cdef PileupProxy dest = PileupProxy.__new__(PileupProxy)
+ */
+
+struct __pyx_obj_9csamtools_PileupProxy {
+ PyObject_HEAD
+ bam_pileup1_t *plp;
+ int tid;
+ int pos;
+ int n_pu;
+};
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1542
+ * return ret
+ *
+ * cdef class IteratorColumn: # <<<<<<<<<<<<<<
+ * '''abstract base class for iterators over columns.
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorColumn {
+ int (*cnext)(struct __pyx_obj_9csamtools_IteratorColumn *);
+ char *(*getSequence)(struct __pyx_obj_9csamtools_IteratorColumn *);
+ PyObject *(*setMask)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *);
+ PyObject *(*setupIteratorData)(struct __pyx_obj_9csamtools_IteratorColumn *, int, int, int, struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData *__pyx_optional_args);
+ PyObject *(*reset)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *, PyObject *, PyObject *);
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+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1712
+ * self.iterdata.seq = NULL
+ *
+ * cdef class IteratorColumnRegion(IteratorColumn): # <<<<<<<<<<<<<<
+ * '''iterates over a region only.
+ * '''
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion {
+ struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_base;
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+static struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion *__pyx_vtabptr_9csamtools_IteratorColumnRegion;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2873
+ *
+ *
+ * cdef class SNPCallerBase: # <<<<<<<<<<<<<<
+ * '''Base class for SNP callers.
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_SNPCallerBase {
+ PyObject *(*__dump)(struct __pyx_obj_9csamtools_SNPCallerBase *, glf1_t *, uint32_t, int);
+};
+static struct __pyx_vtabstruct_9csamtools_SNPCallerBase *__pyx_vtabptr_9csamtools_SNPCallerBase;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":3021
+ * return call
+ *
+ * cdef class SNPCaller( SNPCallerBase ): # <<<<<<<<<<<<<<
+ * '''*(IteratorColumn iterator_column )*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_SNPCaller {
+ struct __pyx_vtabstruct_9csamtools_SNPCallerBase __pyx_base;
+};
+static struct __pyx_vtabstruct_9csamtools_SNPCaller *__pyx_vtabptr_9csamtools_SNPCaller;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1206
+ * pass
+ *
+ * cdef class IteratorRowRegion(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile, int tid, int beg, int end, int reopen = True )*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorRowRegion {
+ bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowRegion *);
+ int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowRegion *);
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorRowRegion *__pyx_vtabptr_9csamtools_IteratorRowRegion;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1402
+ * raise StopIteration
+ *
+ * cdef class IteratorRowSelection(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile)*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorRowSelection {
+ bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowSelection *);
+ int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowSelection *);
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorRowSelection *__pyx_vtabptr_9csamtools_IteratorRowSelection;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1741
+ * self.n_plp )
+ *
+ * cdef class IteratorColumnAllRefs(IteratorColumn): # <<<<<<<<<<<<<<
+ * """iterates over all columns by chaining iterators over each reference
+ * """
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorColumnAllRefs {
+ struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_base;
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorColumnAllRefs *__pyx_vtabptr_9csamtools_IteratorColumnAllRefs;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":415
+ *
+ *
+ * cdef class Samfile: # <<<<<<<<<<<<<<
+ * '''*(filename, mode=None, template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_Samfile {
+ bam_header_t *(*_buildHeader)(struct __pyx_obj_9csamtools_Samfile *, PyObject *);
+ bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_Samfile *);
+ int (*cnext)(struct __pyx_obj_9csamtools_Samfile *);
+ int (*write)(struct __pyx_obj_9csamtools_Samfile *, struct __pyx_obj_9csamtools_AlignedRead *, int __pyx_skip_dispatch);
+ char *(*_getrname)(struct __pyx_obj_9csamtools_Samfile *, int);
+};
+static struct __pyx_vtabstruct_9csamtools_Samfile *__pyx_vtabptr_9csamtools_Samfile;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":244
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+ * ######################################################################
+ * cdef class Fastafile: # <<<<<<<<<<<<<<
+ * '''*(filename)*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_Fastafile {
+ char *(*_fetch)(struct __pyx_obj_9csamtools_Fastafile *, char *, int, int, int *);
+};
+static struct __pyx_vtabstruct_9csamtools_Fastafile *__pyx_vtabptr_9csamtools_Fastafile;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":1292
+ * if self.owns_samfile: samclose( self.fp )
+ *
+ * cdef class IteratorRowAll(IteratorRow): # <<<<<<<<<<<<<<
+ * """*(Samfile samfile, int reopen = True)*
+ *
+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorRowAll {
+ bam1_t *(*getCurrent)(struct __pyx_obj_9csamtools_IteratorRowAll *);
+ int (*cnext)(struct __pyx_obj_9csamtools_IteratorRowAll *);
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+static struct __pyx_vtabstruct_9csamtools_IteratorRowAll *__pyx_vtabptr_9csamtools_IteratorRowAll;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":2946
+ * sys.stdout.flush()
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+ * cdef class IteratorSNPCalls( SNPCallerBase ): # <<<<<<<<<<<<<<
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+ */
+
+struct __pyx_vtabstruct_9csamtools_IteratorSNPCalls {
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+#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_List_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ PyObject *r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Tuple_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ PyObject *r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+
+#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
+ r = PySequence_GetItem(o, i);
+ }
+ else {
+ r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+ }
+ return r;
+}
+
+static CYTHON_INLINE long __Pyx_NegateNonNeg(long b) { return unlikely(b < 0) ? b : !b; }
+static CYTHON_INLINE PyObject* __Pyx_PyBoolOrNull_FromLong(long b) {
+ return unlikely(b < 0) ? NULL : __Pyx_PyBool_FromLong(b);
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void);
+
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Append(PyObject* L, PyObject* x) {
+ if (likely(PyList_CheckExact(L))) {
+ if (PyList_Append(L, x) < 0) return NULL;
+ Py_INCREF(Py_None);
+ return Py_None; /* this is just to have an accurate signature */
+ }
+ else {
+ PyObject *r, *m;
+ m = __Pyx_GetAttrString(L, "append");
+ if (!m) return NULL;
+ r = PyObject_CallFunctionObjArgs(m, x, NULL);
+ Py_DECREF(m);
+ return r;
+ }
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
+
+
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
+ PyObject *value;
+ if (unlikely(d == Py_None)) {
+ __Pyx_RaiseNoneIndexingError();
+ return NULL;
+ }
+ value = PyDict_GetItemWithError(d, key);
+ if (unlikely(!value)) {
+ if (!PyErr_Occurred())
+ PyErr_SetObject(PyExc_KeyError, key);
+ return NULL;
+ }
+ Py_INCREF(value);
+ return value;
+}
+#else
+ #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
+#endif
+
+static PyObject* __Pyx_PyDict_GetItemDefault(PyObject* d, PyObject* key, PyObject* default_value) {
+ PyObject* value;
+#if PY_MAJOR_VERSION >= 3
+ value = PyDict_GetItemWithError(d, key);
+ if (unlikely(!value)) {
+ if (unlikely(PyErr_Occurred()))
+ return NULL;
+ value = default_value;
+ }
+ Py_INCREF(value);
+#else
+ if (PyString_CheckExact(key) || PyUnicode_CheckExact(key) || PyInt_CheckExact(key)) {
+ /* these presumably have safe hash functions */
+ value = PyDict_GetItem(d, key);
+ if (unlikely(!value)) {
+ value = default_value;
+ }
+ Py_INCREF(value);
+ } else {
+ PyObject *m;
+ m = __Pyx_GetAttrString(d, "get");
+ if (!m) return NULL;
+ value = PyObject_CallFunctionObjArgs(m, key,
+ (default_value == Py_None) ? NULL : default_value, NULL);
+ Py_DECREF(m);
+ }
+#endif
+ return value;
+}
+
+static CYTHON_INLINE long __Pyx_div_long(long, long); /* proto */
+
+static CYTHON_INLINE long __Pyx_mod_long(long, long); /* proto */
+
+#define __Pyx_DelItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_DelItemInt_Fast(o, i) : \
+ __Pyx_DelItem_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE int __Pyx_DelItem_Generic(PyObject *o, PyObject *j) {
+ int r;
+ if (!j) return -1;
+ r = PyObject_DelItem(o, j);
+ Py_DECREF(j);
+ return r;
+}
+
+static CYTHON_INLINE int __Pyx_DelItemInt_Fast(PyObject *o, Py_ssize_t i) {
+ if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_ass_item && likely(i >= 0))
+ return PySequence_DelItem(o, i);
+ else {
+ PyObject *j = PyInt_FromSsize_t(i);
+ return __Pyx_DelItem_Generic(o, j);
+ }
+}
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
+
+static PyObject *__Pyx_CreateClass(PyObject *bases, PyObject *dict, PyObject *name, const char *modname); /*proto*/
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t);
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject *);
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int32_t(int32_t);
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int64_t(int64_t);
+
+static CYTHON_INLINE uint64_t __Pyx_PyInt_from_py_uint64_t(PyObject *);
+
+static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject *);
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint8_t(uint8_t);
+
+static int __Pyx_Print(PyObject*, PyObject *, int); /*proto*/
+#if PY_MAJOR_VERSION >= 3
+static PyObject* __pyx_print = 0;
+static PyObject* __pyx_print_kwargs = 0;
+#endif
+
+static int __Pyx_PrintOne(PyObject* stream, PyObject *o); /*proto*/
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint64_t(uint64_t);
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
+
+static void __Pyx_WriteUnraisable(const char *name); /*proto*/
+
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict); /*proto*/
+
+static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable); /*proto*/
+
+static void __Pyx_AddTraceback(const char *funcname); /*proto*/
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
+/* Module declarations from __builtin__ */
+
+/* Module declarations from cpython.version */
+
+/* Module declarations from cpython.ref */
+
+/* Module declarations from cpython.exc */
+
+/* Module declarations from cpython.module */
+
+/* Module declarations from cpython.mem */
+
+/* Module declarations from cpython.tuple */
+
+/* Module declarations from cpython.list */
+
+/* Module declarations from libc.stdio */
+
+/* Module declarations from cpython.object */
+
+/* Module declarations from cpython.sequence */
+
+/* Module declarations from cpython.mapping */
+
+/* Module declarations from cpython.iterator */
+
+/* Module declarations from cpython.type */
+
+/* Module declarations from cpython.number */
+
+/* Module declarations from cpython.int */
+
+/* Module declarations from __builtin__ */
+
+/* Module declarations from cpython.bool */
+
+static PyTypeObject *__pyx_ptype_7cpython_4bool_bool = 0;
+/* Module declarations from cpython.long */
+
+/* Module declarations from cpython.float */
+
+/* Module declarations from cpython.complex */
+
+/* Module declarations from cpython.string */
+
+/* Module declarations from cpython.unicode */
+
+/* Module declarations from cpython.dict */
+
+/* Module declarations from cpython.instance */
+
+/* Module declarations from cpython.function */
+
+/* Module declarations from cpython.method */
+
+/* Module declarations from cpython.weakref */
+
+/* Module declarations from cpython.getargs */
+
+/* Module declarations from cpython.pythread */
+
+/* Module declarations from cpython.cobject */
+
+/* Module declarations from cpython.oldbuffer */
+
+/* Module declarations from cpython.set */
+
+/* Module declarations from cpython.buffer */
+
+/* Module declarations from cpython.bytes */
+
+/* Module declarations from cpython.pycapsule */
+
+/* Module declarations from cpython */
+
+/* Module declarations from csamtools */
+
+static PyTypeObject *__pyx_ptype_9csamtools_file = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_AlignedRead = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_Samfile = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_PileupProxy = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_PileupRead = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_Fastafile = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorRow = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowRegion = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowAll = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowAllRefs = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorRowSelection = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumn = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumnRegion = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorColumnAllRefs = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_SNPCall = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_SNPCallerBase = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorSNPCalls = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_SNPCaller = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IndelCall = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IndelCallerBase = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IndelCaller = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IteratorIndelCalls = 0;
+static PyTypeObject *__pyx_ptype_9csamtools_IndexedReads = 0;
+static char *__pyx_v_9csamtools_bam_nt16_rev_table;
+static int __pyx_v_9csamtools_max_pos;
+static PyObject *__pyx_f_9csamtools_makeAlignedRead(bam1_t *); /*proto*/
+static PyObject *__pyx_f_9csamtools_makePileupProxy(bam_pileup1_t *, int, int, int); /*proto*/
+static PyObject *__pyx_f_9csamtools_makePileupRead(bam_pileup1_t *); /*proto*/
+static int __pyx_f_9csamtools_fetch_callback(bam1_t *, void *); /*proto*/
+static int __pyx_f_9csamtools_pileup_callback(uint32_t, uint32_t, int, bam_pileup1_t *, void *); /*proto*/
+static int __pyx_f_9csamtools_pileup_fetch_callback(bam1_t *, void *); /*proto*/
+static int __pyx_f_9csamtools_count_callback(bam1_t *, void *); /*proto*/
+static int __pyx_f_9csamtools_mate_callback(bam1_t *, void *); /*proto*/
+static int __pyx_f_9csamtools___advance_all(void *, bam1_t *); /*proto*/
+static int __pyx_f_9csamtools___advance_snpcalls(void *, bam1_t *); /*proto*/
+static CYTHON_INLINE int32_t __pyx_f_9csamtools_query_start(bam1_t *); /*proto*/
+static CYTHON_INLINE int32_t __pyx_f_9csamtools_query_end(bam1_t *); /*proto*/
+static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_seq_range(bam1_t *, uint32_t, uint32_t); /*proto*/
+static CYTHON_INLINE PyObject *__pyx_f_9csamtools_get_qual_range(bam1_t *, uint32_t, uint32_t); /*proto*/
+#define __Pyx_MODULE_NAME "csamtools"
+int __pyx_module_is_main_csamtools = 0;
+
+/* Implementation of csamtools */
+static PyObject *__pyx_builtin_open;
+static PyObject *__pyx_builtin_object;
+static PyObject *__pyx_builtin_map;
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_IOError;
+static PyObject *__pyx_builtin_OverflowError;
+static PyObject *__pyx_builtin_NotImplementedError;
+static PyObject *__pyx_builtin_KeyError;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_cmp;
+static PyObject *__pyx_builtin_chr;
+static PyObject *__pyx_builtin_TypeError;
+static PyObject *__pyx_builtin_range;
+static char __pyx_k_1[] = "\t";
+static char __pyx_k_2[] = "\n";
+static char __pyx_k_3[] = "calling len() on closed file";
+static char __pyx_k_4[] = "could not open file `%s`";
+static char __pyx_k_5[] = "I/O operation on closed file";
+static char __pyx_k_6[] = "no sequence/region supplied.";
+static char __pyx_k_7[] = "invalid region: start (%i) > end (%i)";
+static char __pyx_k_8[] = "";
+static char __pyx_k_9[] = "start out of range (%i)";
+static char __pyx_k_10[] = "end out of range (%i)";
+static char __pyx_k_11[] = "%s:%i-%i";
+static char __pyx_k_12[] = "invalid file opening mode `%s`";
+static char __pyx_k_13[] = "http:";
+static char __pyx_k_14[] = "ftp:";
+static char __pyx_k_15[] = "either supply options `template`, `header` or both `referencenames` and `referencelengths` for writing";
+static char __pyx_k_16[] = "unequal names and lengths of reference sequences";
+static char __pyx_k_17[] = "-";
+static char __pyx_k_18[] = "file `%s` not found";
+static char __pyx_k_19[] = "could not open file (mode='%s') - is it SAM/BAM format?";
+static char __pyx_k_20[] = "file does not have valid header (mode='%s') - is it SAM/BAM format?";
+static char __pyx_k_21[] = "file header is empty (mode='%s') - is it SAM/BAM format?";
+static char __pyx_k_22[] = ".bai";
+static char __pyx_k_23[] = "error while opening index `%s` ";
+static char __pyx_k_24[] = "tid %i out of range 0<=tid<%i";
+static char __pyx_k_25[] = "[:-]";
+static char __pyx_k_26[] = "invalid reference `%s`";
+static char __pyx_k_27[] = "invalid coordinates: start (%i) > end (%i)";
+static char __pyx_k_28[] = "seek only available in bam files";
+static char __pyx_k_30[] = "fetch called on bamfile without index";
+static char __pyx_k_31[] = "callback functionality requires a region/reference";
+static char __pyx_k_32[] = "no index available for fetch";
+static char __pyx_k_33[] = "fetch called for samfile without header";
+static char __pyx_k_34[] = "fetch for a region is not available for sam files";
+static char __pyx_k_35[] = "callback not implemented yet";
+static char __pyx_k_36[] = "read %s: is unpaired";
+static char __pyx_k_37[] = "mate %s: is unmapped";
+static char __pyx_k_38[] = "mate not found";
+static char __pyx_k_40[] = "counting functionality requires a region/reference";
+static char __pyx_k_41[] = "count for a region is not available for sam files";
+static char __pyx_k_42[] = "no index available for pileup";
+static char __pyx_k_43[] = "pileup of samfiles not implemented yet";
+static char __pyx_k_44[] = "@";
+static char __pyx_k_45[] = "header line without '@': '%s'";
+static char __pyx_k_46[] = "header line with invalid type '%s': '%s'";
+static char __pyx_k_47[] = ":";
+static char __pyx_k_48[] = "unknown field code '%s' in record '%s'";
+static char __pyx_k_49[] = "multiple '%s' lines are not permitted";
+static char __pyx_k_50[] = "@%s";
+static char __pyx_k_51[] = "%s:%s";
+static char __pyx_k_52[] = "invalid type for record %s: %s, expected %s";
+static char __pyx_k_53[] = "incomplete sequence information in '%s'";
+static char __pyx_k_54[] = "no index available for iteration";
+static char __pyx_k_55[] = "can only use this iterator on bam files";
+static char __pyx_k_56[] = "reference sequence for '%s' (tid=%i) not found";
+static char __pyx_k_57[] = "unknown stepper option `%s` in IteratorColumn";
+static char __pyx_k_59[] = "error during iteration";
+static char __pyx_k_60[] = "Invalid clipping in CIGAR string";
+static char __pyx_k_61[] = "quality and sequence mismatch: %i != %i";
+static char __pyx_k_62[] = "%c";
+static char __pyx_k_63[] = "create_string_buffer";
+static char __pyx_k_64[] = "<cccf";
+static char __pyx_k_65[] = "<cccb";
+static char __pyx_k_66[] = "<ccch";
+static char __pyx_k_67[] = "integer %i out of range of BAM/SAM specification";
+static char __pyx_k_68[] = "<ccci";
+static char __pyx_k_69[] = "<cccB";
+static char __pyx_k_70[] = "<cccH";
+static char __pyx_k_71[] = "<cccI";
+static char __pyx_k_72[] = "<cccc";
+static char __pyx_k_73[] = "<ccc%is";
+static char __pyx_k_74[] = "tags field too large";
+static char __pyx_k_75[] = "tag '%s' not present";
+static char __pyx_k_76[] = "Contig index";
+static char __pyx_k_77[] = "Mapped position on contig";
+static char __pyx_k_78[] = "Contig index for mate pair";
+static char __pyx_k_79[] = "Position of mate pair";
+static char __pyx_k_80[] = "Insert size";
+static char __pyx_k_81[] = "Binary flag";
+static char __pyx_k_82[] = "Count of cigar entries";
+static char __pyx_k_83[] = "Cigar entries";
+static char __pyx_k_84[] = "Mapping quality";
+static char __pyx_k_85[] = "Bam index bin number";
+static char __pyx_k_86[] = "Length of query name";
+static char __pyx_k_87[] = "Query name";
+static char __pyx_k_88[] = "Length of query sequence";
+static char __pyx_k_89[] = "Query sequence";
+static char __pyx_k_90[] = "Quality scores";
+static char __pyx_k_91[] = "Length of auxilary data";
+static char __pyx_k_92[] = "Maximum data length";
+static char __pyx_k_93[] = "Current data length";
+static char __pyx_k_94[] = "%-30s %-10s= %s";
+static char __pyx_k_95[] = "(";
+static char __pyx_k_96[] = ")";
+static char __pyx_k_97[] = "This class cannot be instantiated from Python";
+static char __pyx_k__A[] = "A";
+static char __pyx_k__C[] = "C";
+static char __pyx_k__D[] = "D";
+static char __pyx_k__F[] = "F";
+static char __pyx_k__I[] = "I";
+static char __pyx_k__S[] = "S";
+static char __pyx_k__Z[] = "Z";
+static char __pyx_k__b[] = "b";
+static char __pyx_k__c[] = "c";
+static char __pyx_k__d[] = "d";
+static char __pyx_k__f[] = "f";
+static char __pyx_k__i[] = "i";
+static char __pyx_k__n[] = "n";
+static char __pyx_k__r[] = "r";
+static char __pyx_k__s[] = "s";
+static char __pyx_k__w[] = "w";
+static char __pyx_k__x[] = "x";
+static char __pyx_k_100[] = "No such file or directory: '%s'";
+static char __pyx_k_101[] = "-o";
+static char __pyx_k_102[] = "option -o is forbidden in samtools view";
+static char __pyx_k_103[] = "_rms_mapping_quality";
+static char __pyx_k_104[] = "--> read %i %s %i";
+static char __pyx_k_105[] = "pos=%i, cns=%i, q_r = %f, depth=%i, n=%i, rb=%i, cns-cq=%i %i %i %i";
+static char __pyx_k_106[] = "-------------------------------------\n";
+static char __pyx_k_107[] = "IteratorSNPCalls requires an pileup iterator with reference sequence";
+static char __pyx_k_108[] = "position %i out of bounds on reference sequence (len=%i)";
+static char __pyx_k_109[] = "no reads in region - no call";
+static char __pyx_k_110[] = "%s/%s";
+static char __pyx_k_111[] = "IndelCallerBase requires an pileup iterator with reference sequence";
+static char __pyx_k_112[] = "can only IndexReads on bam files";
+static char __pyx_k_113[] = "read %s not found";
+static char __pyx_k_114[] = "the query name (None if not present)";
+static char __pyx_k_115[] = "the :term:`cigar` alignment (None if not present).\n ";
+static char __pyx_k_116[] = "read sequence bases, including :term:`soft clipped` bases (None if not present)";
+static char __pyx_k_117[] = "read sequence base qualities, including :term:`soft clipped` bases (None if not present)";
+static char __pyx_k_118[] = "aligned portion of the read and excludes any flanking bases that were :term:`soft clipped` (None if not present)\n\n SAM/BAM files may included extra flanking bases sequences that were\n not part of the alignment. These bases may be the result of the\n Smith-Waterman or other algorithms, which may not require alignments\n that begin at the first residue or end at the last. In addition,\n extra sequencing adapters, multiplex identifiers, and low-quality bases that\n were not considered for alignment may have been retained.";
+static char __pyx_k_119[] = "aligned query sequence quality values (None if not present)";
+static char __pyx_k_120[] = "start index of the aligned query portion of the sequence (0-based, inclusive)";
+static char __pyx_k_121[] = "end index of the aligned query portion of the sequence (0-based, exclusive)";
+static char __pyx_k_122[] = "Length of the aligned query sequence";
+static char __pyx_k_123[] = "the tags in the AUX field.\n\n This property permits convenience access to \n the tags. Changes it the returned list will\n not update the tags automatically. Instead,\n the following is required for adding a \n new tag::\n\n read.tags = read.tags + [(\"RG\",0)]\n\n ";
+static char __pyx_k_124[] = "properties flag";
+static char __pyx_k_125[] = "\n :term:`target` ID\n\n DEPRECATED from pysam-0.4 - use tid in the future.\n The rname field caused a lot of confusion as it returns\n the :term:`target` ID instead of the reference sequence\n name.\n\n .. note::\n\n This field contains the index of the reference sequence \n in the sequence dictionary. To obtain the name\n of the reference sequence, use :meth:`pysam.Samfile.getrname()`\n \n ";
+static char __pyx_k_126[] = "\n :term:`target` ID\n\n .. note::\n\n This field contains the index of the reference sequence \n in the sequence dictionary. To obtain the name\n of the reference sequence, use :meth:`pysam.Samfile.getrname()`\n \n ";
+static char __pyx_k_127[] = "0-based leftmost coordinate";
+static char __pyx_k_128[] = "properties bin";
+static char __pyx_k_129[] = "length of the read (read only). Returns 0 if not given.";
+static char __pyx_k_130[] = "aligned end position of the read (read only). Returns\n None if not available.";
+static char __pyx_k_131[] = "aligned length of the read (read only). Returns None if\n not available.";
+static char __pyx_k_132[] = "mapping quality";
+static char __pyx_k_133[] = "the :term:`reference` id of the mate ";
+static char __pyx_k_134[] = "the position of the mate";
+static char __pyx_k_135[] = "the insert size";
+static char __pyx_k_136[] = "true if read is paired in sequencing";
+static char __pyx_k_137[] = "true if read is mapped in a proper pair";
+static char __pyx_k_138[] = "true if read itself is unmapped";
+static char __pyx_k_139[] = "true if the mate is unmapped";
+static char __pyx_k_140[] = "true if read is mapped to reverse strand";
+static char __pyx_k_141[] = "true is read is mapped to reverse strand";
+static char __pyx_k_142[] = "true if this is read1";
+static char __pyx_k_143[] = "true if this is read2";
+static char __pyx_k_144[] = "true if not primary alignment";
+static char __pyx_k_145[] = "true if QC failure";
+static char __pyx_k_146[] = "true if optical or PCR duplicate";
+static char __pyx_k_147[] = "a list of reference positions that this read aligns to.";
+static char __pyx_k_148[] = "number of :term:`filename` associated with this object.";
+static char __pyx_k_149[] = "number of :term:`reference` sequences in the file.";
+static char __pyx_k_150[] = "tuple with the names of :term:`reference` sequences.";
+static char __pyx_k_151[] = "tuple of the lengths of the :term:`reference` sequences. The lengths are in the same order as \n :attr:`pysam.Samfile.references`\n ";
+static char __pyx_k_152[] = "full contents of the :term:`sam file` header as a string.";
+static char __pyx_k_153[] = "header information within the :term:`sam file`. The records and fields are returned as \n a two-level dictionary.\n ";
+static char __pyx_k_154[] = "the chromosome ID as is defined in the header";
+static char __pyx_k_155[] = "number of reads mapping to this column.";
+static char __pyx_k_156[] = "list of reads (:class:`pysam.PileupRead`) aligned to this column";
+static char __pyx_k_157[] = "a :class:`pysam.AlignedRead` object of the aligned read";
+static char __pyx_k_158[] = "position of the read base at the pileup site, 0-based";
+static char __pyx_k_159[] = "indel length; 0 for no indel, positive for ins and negative for del";
+static char __pyx_k_160[] = "1 iff the base on the padded read is a deletion";
+static char __pyx_k_161[] = "current sequence length.";
+static char __pyx_k_162[] = "nucleotide position of SNP.";
+static char __pyx_k_163[] = "reference base at pos. ``N`` if no reference sequence supplied.";
+static char __pyx_k_164[] = "the genotype called.";
+static char __pyx_k_165[] = "the genotype quality (Phred-scaled).";
+static char __pyx_k_166[] = "the snp quality (Phred scaled) - probability of consensus being identical to reference sequence.";
+static char __pyx_k_167[] = "the root mean square (rms) of the mapping quality of all reads involved in the call.";
+static char __pyx_k_168[] = "coverage or read depth - the number of reads involved in the call.";
+static char __pyx_k_169[] = "sequence of first allele.";
+static char __pyx_k_170[] = "sequence of second allele.";
+static char __pyx_k_171[] = "reads supporting first allele.";
+static char __pyx_k_172[] = "=ACMGRSVTWYHKDBN";
+static char __pyx_k_173[] = "A pileup column. A pileup column contains \n all the reads that map to a certain target base.\n\n tid \n chromosome ID as is defined in the header \n pos \n the target base coordinate (0-based) \n n \n number of reads mapping to this column \n pileups \n list of reads (:class:`pysam.PileupRead`) aligned to this column \n ";
+static char __pyx_k_174[] = "\n stderr is captured. \n ";
+static char __pyx_k_175[] = "does nothing. stderr can't be redirected on windows";
+static char __pyx_k_176[] = "http://mail.python.org/pipermail/python-list/2000-June/038406.html";
+static char __pyx_k_177[] = "Fastafile._isOpen (line 265)";
+static char __pyx_k_178[] = "Fastafile._open (line 275)";
+static char __pyx_k_179[] = "Fastafile.fetch (line 306)";
+static char __pyx_k_180[] = "Samfile._isOpen (line 464)";
+static char __pyx_k_181[] = "Samfile._hasIndex (line 468)";
+static char __pyx_k_182[] = "Samfile._open (line 472)";
+static char __pyx_k_183[] = "Samfile.gettid (line 612)";
+static char __pyx_k_184[] = "Samfile.getrname (line 621)";
+static char __pyx_k_185[] = "Samfile._parseRegion (line 637)";
+static char __pyx_k_186[] = "Samfile.seek (line 691)";
+static char __pyx_k_187[] = "Samfile.tell (line 702)";
+static char __pyx_k_188[] = "Samfile.fetch (line 713)";
+static char __pyx_k_189[] = "Samfile.mate (line 782)";
+static char __pyx_k_190[] = "Samfile.count (line 825)";
+static char __pyx_k_191[] = "Samfile.pileup (line 869)";
+static char __pyx_k_192[] = "Samfile.close (line 953)";
+static char __pyx_k_193[] = "Samfile.write (line 969)";
+static char __pyx_k_194[] = "Samfile._buildLine (line 1078)";
+static char __pyx_k_195[] = "Samfile.__next__ (line 1173)";
+static char __pyx_k_196[] = "IteratorRowRegion.__next__ (line 1281)";
+static char __pyx_k_197[] = "IteratorRowAll.__next__ (line 1340)";
+static char __pyx_k_198[] = "IteratorRowAllRefs.__next__ (line 1375)";
+static char __pyx_k_199[] = "IteratorRowSelection.__next__ (line 1459)";
+static char __pyx_k_200[] = "IteratorRowSelection";
+static char __pyx_k_201[] = "IteratorColumn.addReference (line 1634)";
+static char __pyx_k_202[] = "IteratorColumn.hasReference (line 1642)";
+static char __pyx_k_203[] = "IteratorColumnRegion.__next__ (line 1724)";
+static char __pyx_k_204[] = "IteratorColumnRegion";
+static char __pyx_k_205[] = "IteratorColumnAllRefs.__next__ (line 1755)";
+static char __pyx_k_206[] = "IteratorColumnAllRefs";
+static char __pyx_k_207[] = "AlignedRead.__str__ (line 1903)";
+static char __pyx_k_208[] = "AlignedRead.compare (line 1928)";
+static char __pyx_k_209[] = "AlignedRead.overlap (line 2512)";
+static char __pyx_k_210[] = "AlignedRead.opt (line 2541)";
+static char __pyx_k_211[] = "AlignedRead.fancy_str (line 2563)";
+static char __pyx_k_212[] = "Outs.setdevice (line 2705)";
+static char __pyx_k_213[] = "Outs.setfile (line 2710)";
+static char __pyx_k_214[] = "Outs.restore (line 2723)";
+static char __pyx_k_215[] = "_samtools_dispatch (line 2734)";
+static char __pyx_k_216[] = "IteratorSNPCalls.__next__ (line 2969)";
+static char __pyx_k_217[] = "SNPCaller.call (line 3041)";
+static char __pyx_k_218[] = "IndelCaller.call (line 3306)";
+static char __pyx_k_219[] = "IteratorIndelCalls.__next__ (line 3353)";
+static char __pyx_k_220[] = "IndexedReads.build (line 3406)";
+static char __pyx_k__AS[] = "AS";
+static char __pyx_k__CL[] = "CL";
+static char __pyx_k__CN[] = "CN";
+static char __pyx_k__CO[] = "CO";
+static char __pyx_k__DS[] = "DS";
+static char __pyx_k__DT[] = "DT";
+static char __pyx_k__GO[] = "GO";
+static char __pyx_k__HD[] = "HD";
+static char __pyx_k__ID[] = "ID";
+static char __pyx_k__LB[] = "LB";
+static char __pyx_k__LN[] = "LN";
+static char __pyx_k__M5[] = "M5";
+static char __pyx_k__PG[] = "PG";
+static char __pyx_k__PI[] = "PI";
+static char __pyx_k__PL[] = "PL";
+static char __pyx_k__PN[] = "PN";
+static char __pyx_k__PU[] = "PU";
+static char __pyx_k__RG[] = "RG";
+static char __pyx_k__SM[] = "SM";
+static char __pyx_k__SN[] = "SN";
+static char __pyx_k__SO[] = "SO";
+static char __pyx_k__SP[] = "SP";
+static char __pyx_k__SQ[] = "SQ";
+static char __pyx_k__UR[] = "UR";
+static char __pyx_k__VN[] = "VN";
+static char __pyx_k___r[] = "_r";
+static char __pyx_k__fd[] = "fd";
+static char __pyx_k__fp[] = "fp";
+static char __pyx_k__id[] = "id";
+static char __pyx_k__os[] = "os";
+static char __pyx_k__rb[] = "rb";
+static char __pyx_k__re[] = "re";
+static char __pyx_k__wb[] = "wb";
+static char __pyx_k__wh[] = "wh";
+static char __pyx_k__all[] = "all";
+static char __pyx_k__bam[] = "bam";
+static char __pyx_k__beg[] = "beg";
+static char __pyx_k__bin[] = "bin";
+static char __pyx_k__chr[] = "chr";
+static char __pyx_k__cmp[] = "cmp";
+static char __pyx_k__dup[] = "dup";
+static char __pyx_k__end[] = "end";
+static char __pyx_k__map[] = "map";
+static char __pyx_k__opt[] = "opt";
+static char __pyx_k__plp[] = "plp";
+static char __pyx_k__pos[] = "pos";
+static char __pyx_k__q_r[] = "q_r";
+static char __pyx_k__raw[] = "raw";
+static char __pyx_k__seq[] = "seq";
+static char __pyx_k__sys[] = "sys";
+static char __pyx_k__tid[] = "tid";
+static char __pyx_k__wbu[] = "wbu";
+static char __pyx_k__Outs[] = "Outs";
+static char __pyx_k___pos[] = "_pos";
+static char __pyx_k___tid[] = "_tid";
+static char __pyx_k__args[] = "args";
+static char __pyx_k__call[] = "call";
+static char __pyx_k__cnt1[] = "cnt1";
+static char __pyx_k__cnt2[] = "cnt2";
+static char __pyx_k__core[] = "core";
+static char __pyx_k__data[] = "data";
+static char __pyx_k__dup2[] = "dup2";
+static char __pyx_k__flag[] = "flag";
+static char __pyx_k__hash[] = "hash";
+static char __pyx_k__iter[] = "iter";
+static char __pyx_k__join[] = "join";
+static char __pyx_k__mapq[] = "mapq";
+static char __pyx_k__mask[] = "mask";
+static char __pyx_k__mate[] = "mate";
+static char __pyx_k__mode[] = "mode";
+static char __pyx_k__mpos[] = "mpos";
+static char __pyx_k__mrnm[] = "mrnm";
+static char __pyx_k__mtid[] = "mtid";
+static char __pyx_k__n_pu[] = "n_pu";
+static char __pyx_k__name[] = "name";
+static char __pyx_k__open[] = "open";
+static char __pyx_k__path[] = "path";
+static char __pyx_k__port[] = "port";
+static char __pyx_k__qpos[] = "qpos";
+static char __pyx_k__qseq[] = "qseq";
+static char __pyx_k__qual[] = "qual";
+static char __pyx_k__rlen[] = "rlen";
+static char __pyx_k__seek[] = "seek";
+static char __pyx_k__self[] = "self";
+static char __pyx_k__tags[] = "tags";
+static char __pyx_k__tell[] = "tell";
+static char __pyx_k__text[] = "text";
+static char __pyx_k__view[] = "view";
+static char __pyx_k___call[] = "_call";
+static char __pyx_k___open[] = "_open";
+static char __pyx_k___qpos[] = "_qpos";
+static char __pyx_k__bqual[] = "bqual";
+static char __pyx_k__build[] = "build";
+static char __pyx_k__cigar[] = "cigar";
+static char __pyx_k__close[] = "close";
+static char __pyx_k__cnext[] = "cnext";
+static char __pyx_k__count[] = "count";
+static char __pyx_k__fetch[] = "fetch";
+static char __pyx_k__flush[] = "flush";
+static char __pyx_k__indel[] = "indel";
+static char __pyx_k__index[] = "index";
+static char __pyx_k__isbam[] = "isbam";
+static char __pyx_k__isize[] = "isize";
+static char __pyx_k__l_aux[] = "l_aux";
+static char __pyx_k__level[] = "level";
+static char __pyx_k__n_hap[] = "n_hap";
+static char __pyx_k__n_plp[] = "n_plp";
+static char __pyx_k__q_cns[] = "q_cns";
+static char __pyx_k__q_ref[] = "q_ref";
+static char __pyx_k__qname[] = "qname";
+static char __pyx_k__range[] = "range";
+static char __pyx_k__reset[] = "reset";
+static char __pyx_k__rname[] = "rname";
+static char __pyx_k__setfd[] = "setfd";
+static char __pyx_k__split[] = "split";
+static char __pyx_k__start[] = "start";
+static char __pyx_k__strip[] = "strip";
+static char __pyx_k__theta[] = "theta";
+static char __pyx_k__types[] = "types";
+static char __pyx_k__where[] = "where";
+static char __pyx_k__write[] = "write";
+static char __pyx_k___indel[] = "_indel";
+static char __pyx_k___level[] = "_level";
+static char __pyx_k__ctypes[] = "ctypes";
+static char __pyx_k__errmod[] = "errmod";
+static char __pyx_k__exists[] = "exists";
+static char __pyx_k__fields[] = "fields";
+static char __pyx_k__fileno[] = "fileno";
+static char __pyx_k__gettid[] = "gettid";
+static char __pyx_k__header[] = "header";
+static char __pyx_k__indel1[] = "indel1";
+static char __pyx_k__indel2[] = "indel2";
+static char __pyx_k__is_del[] = "is_del";
+static char __pyx_k__l_qseq[] = "l_qseq";
+static char __pyx_k__l_text[] = "l_text";
+static char __pyx_k__m_data[] = "m_data";
+static char __pyx_k__method[] = "method";
+static char __pyx_k__object[] = "object";
+static char __pyx_k__offset[] = "offset";
+static char __pyx_k__pileup[] = "pileup";
+static char __pyx_k__record[] = "record";
+static char __pyx_k__region[] = "region";
+static char __pyx_k__remove[] = "remove";
+static char __pyx_k__reopen[] = "reopen";
+static char __pyx_k__retval[] = "retval";
+static char __pyx_k__rg2lib[] = "rg2lib";
+static char __pyx_k__stderr[] = "stderr";
+static char __pyx_k__stdout[] = "stdout";
+static char __pyx_k__struct[] = "struct";
+static char __pyx_k__system[] = "system";
+static char __pyx_k__IOError[] = "IOError";
+static char __pyx_k__IntType[] = "IntType";
+static char __pyx_k__O_CREAT[] = "O_CREAT";
+static char __pyx_k__Samfile[] = "Samfile";
+static char __pyx_k__Windows[] = "Windows";
+static char __pyx_k____all__[] = "__all__";
+static char __pyx_k____del__[] = "__del__";
+static char __pyx_k____str__[] = "__str__";
+static char __pyx_k___isOpen[] = "_isOpen";
+static char __pyx_k___is_del[] = "_is_del";
+static char __pyx_k__compare[] = "compare";
+static char __pyx_k__devnull[] = "devnull";
+static char __pyx_k__is_head[] = "is_head";
+static char __pyx_k__is_tail[] = "is_tail";
+static char __pyx_k__isupper[] = "isupper";
+static char __pyx_k__l_qname[] = "l_qname";
+static char __pyx_k__mkstemp[] = "mkstemp";
+static char __pyx_k__n_cigar[] = "n_cigar";
+static char __pyx_k__options[] = "options";
+static char __pyx_k__overlap[] = "overlap";
+static char __pyx_k__pileups[] = "pileups";
+static char __pyx_k__q_indel[] = "q_indel";
+static char __pyx_k__r_indel[] = "r_indel";
+static char __pyx_k__release[] = "release";
+static char __pyx_k__restore[] = "restore";
+static char __pyx_k__rowiter[] = "rowiter";
+static char __pyx_k__samfile[] = "samfile";
+static char __pyx_k__seq_len[] = "seq_len";
+static char __pyx_k__setfile[] = "setfile";
+static char __pyx_k__stepper[] = "stepper";
+static char __pyx_k__streams[] = "streams";
+static char __pyx_k__DictType[] = "DictType";
+static char __pyx_k__KeyError[] = "KeyError";
+static char __pyx_k__O_WRONLY[] = "O_WRONLY";
+static char __pyx_k____dict__[] = "__dict__";
+static char __pyx_k____init__[] = "__init__";
+static char __pyx_k____main__[] = "__main__";
+static char __pyx_k____next__[] = "__next__";
+static char __pyx_k____test__[] = "__test__";
+static char __pyx_k___is_head[] = "_is_head";
+static char __pyx_k___is_tail[] = "_is_tail";
+static char __pyx_k___logfile[] = "_logfile";
+static char __pyx_k__calcsize[] = "calcsize";
+static char __pyx_k__callback[] = "callback";
+static char __pyx_k__cap_mapQ[] = "cap_mapQ";
+static char __pyx_k__cnt_anti[] = "cnt_anti";
+static char __pyx_k__coverage[] = "coverage";
+static char __pyx_k__data_len[] = "data_len";
+static char __pyx_k__exc_type[] = "exc_type";
+static char __pyx_k__filename[] = "filename";
+static char __pyx_k__genotype[] = "genotype";
+static char __pyx_k__getrname[] = "getrname";
+static char __pyx_k__het_rate[] = "het_rate";
+static char __pyx_k__isremote[] = "isremote";
+static char __pyx_k__iterdata[] = "iterdata";
+static char __pyx_k__nextiter[] = "nextiter";
+static char __pyx_k__platform[] = "platform";
+static char __pyx_k__samtools[] = "samtools";
+static char __pyx_k__stderr_f[] = "stderr_f";
+static char __pyx_k__stderr_h[] = "stderr_h";
+static char __pyx_k__tempfile[] = "tempfile";
+static char __pyx_k__template[] = "template";
+static char __pyx_k__Fastafile[] = "Fastafile";
+static char __pyx_k__FloatType[] = "FloatType";
+static char __pyx_k__SNPCaller[] = "SNPCaller";
+static char __pyx_k__TypeError[] = "TypeError";
+static char __pyx_k___coverage[] = "_coverage";
+static char __pyx_k___delegate[] = "_delegate";
+static char __pyx_k___filename[] = "_filename";
+static char __pyx_k___genotype[] = "_genotype";
+static char __pyx_k___hasIndex[] = "_hasIndex";
+static char __pyx_k__alignment[] = "alignment";
+static char __pyx_k__exc_value[] = "exc_value";
+static char __pyx_k__fancy_str[] = "fancy_str";
+static char __pyx_k__fastafile[] = "fastafile";
+static char __pyx_k__itertools[] = "itertools";
+static char __pyx_k__max_depth[] = "max_depth";
+static char __pyx_k__min_baseQ[] = "min_baseQ";
+static char __pyx_k__n_targets[] = "n_targets";
+static char __pyx_k__pack_into[] = "pack_into";
+static char __pyx_k__positions[] = "positions";
+static char __pyx_k__readlines[] = "readlines";
+static char __pyx_k__reference[] = "reference";
+static char __pyx_k__setdevice[] = "setdevice";
+static char __pyx_k__traceback[] = "traceback";
+static char __pyx_k__until_eof[] = "until_eof";
+static char __pyx_k__PileupRead[] = "PileupRead";
+static char __pyx_k__ValueError[] = "ValueError";
+static char __pyx_k___alignment[] = "_alignment";
+static char __pyx_k___buildLine[] = "_buildLine";
+static char __pyx_k__reads_diff[] = "reads_diff";
+static char __pyx_k__startswith[] = "startswith";
+static char __pyx_k__target_len[] = "target_len";
+static char __pyx_k__AlignedRead[] = "AlignedRead";
+static char __pyx_k__IndelCaller[] = "IndelCaller";
+static char __pyx_k__IteratorRow[] = "IteratorRow";
+static char __pyx_k__PileupProxy[] = "PileupProxy";
+static char __pyx_k__StderrStore[] = "StderrStore";
+static char __pyx_k__collections[] = "collections";
+static char __pyx_k__current_pos[] = "current_pos";
+static char __pyx_k__defaultdict[] = "defaultdict";
+static char __pyx_k__getSequence[] = "getSequence";
+static char __pyx_k__nreferences[] = "nreferences";
+static char __pyx_k__pileup_iter[] = "pileup_iter";
+static char __pyx_k__reads_first[] = "reads_first";
+static char __pyx_k__snp_quality[] = "snp_quality";
+static char __pyx_k__stderr_save[] = "stderr_save";
+static char __pyx_k__target_name[] = "target_name";
+static char __pyx_k__IndexedReads[] = "IndexedReads";
+static char __pyx_k__PileupColumn[] = "PileupColumn";
+static char __pyx_k___buildHeader[] = "_buildHeader";
+static char __pyx_k___parseRegion[] = "_parseRegion";
+static char __pyx_k___snp_quality[] = "_snp_quality";
+static char __pyx_k__addReference[] = "addReference";
+static char __pyx_k__catch_stderr[] = "catch_stderr";
+static char __pyx_k__catch_stdout[] = "catch_stdout";
+static char __pyx_k__first_allele[] = "first_allele";
+static char __pyx_k__hasReference[] = "hasReference";
+static char __pyx_k__n_haplotypes[] = "n_haplotypes";
+static char __pyx_k__owns_samfile[] = "owns_samfile";
+static char __pyx_k__reads_second[] = "reads_second";
+static char __pyx_k__OverflowError[] = "OverflowError";
+static char __pyx_k__StopIteration[] = "StopIteration";
+static char __pyx_k__VALID_HEADERS[] = "VALID_HEADERS";
+static char __pyx_k__second_allele[] = "second_allele";
+static char __pyx_k__IteratorColumn[] = "IteratorColumn";
+static char __pyx_k__IteratorRowAll[] = "IteratorRowAll";
+static char __pyx_k__readAndRelease[] = "readAndRelease";
+static char __pyx_k__reference_base[] = "reference_base";
+static char __pyx_k__referencenames[] = "referencenames";
+static char __pyx_k___reference_base[] = "_reference_base";
+static char __pyx_k__iterator_column[] = "iterator_column";
+static char __pyx_k__mapping_quality[] = "mapping_quality";
+static char __pyx_k__IteratorSNPCalls[] = "IteratorSNPCalls";
+static char __pyx_k____getattribute__[] = "__getattribute__";
+static char __pyx_k__referencelengths[] = "referencelengths";
+static char __pyx_k__IteratorRowRegion[] = "IteratorRowRegion";
+static char __pyx_k__consensus_quality[] = "consensus_quality";
+static char __pyx_k__setupIteratorData[] = "setupIteratorData";
+static char __pyx_k__IteratorIndelCalls[] = "IteratorIndelCalls";
+static char __pyx_k__IteratorRowAllRefs[] = "IteratorRowAllRefs";
+static char __pyx_k__StderrStoreWindows[] = "StderrStoreWindows";
+static char __pyx_k__VALID_HEADER_ORDER[] = "VALID_HEADER_ORDER";
+static char __pyx_k__VALID_HEADER_TYPES[] = "VALID_HEADER_TYPES";
+static char __pyx_k___consensus_quality[] = "_consensus_quality";
+static char __pyx_k___samtools_dispatch[] = "_samtools_dispatch";
+static char __pyx_k__NotImplementedError[] = "NotImplementedError";
+static char __pyx_k__VALID_HEADER_FIELDS[] = "VALID_HEADER_FIELDS";
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+static PyObject *__pyx_kp_s_10;
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+static PyObject *__pyx_n_s__AS;
+static PyObject *__pyx_n_s__AlignedRead;
+static PyObject *__pyx_n_s__C;
+static PyObject *__pyx_n_s__CL;
+static PyObject *__pyx_n_s__CN;
+static PyObject *__pyx_n_s__CO;
+static PyObject *__pyx_n_s__D;
+static PyObject *__pyx_n_s__DS;
+static PyObject *__pyx_n_s__DT;
+static PyObject *__pyx_n_s__DictType;
+static PyObject *__pyx_n_s__F;
+static PyObject *__pyx_n_s__Fastafile;
+static PyObject *__pyx_n_s__FloatType;
+static PyObject *__pyx_n_s__GO;
+static PyObject *__pyx_n_s__HD;
+static PyObject *__pyx_n_s__I;
+static PyObject *__pyx_n_s__ID;
+static PyObject *__pyx_n_s__IOError;
+static PyObject *__pyx_n_s__IndelCaller;
+static PyObject *__pyx_n_s__IndexedReads;
+static PyObject *__pyx_n_s__IntType;
+static PyObject *__pyx_n_s__IteratorColumn;
+static PyObject *__pyx_n_s__IteratorIndelCalls;
+static PyObject *__pyx_n_s__IteratorRow;
+static PyObject *__pyx_n_s__IteratorRowAll;
+static PyObject *__pyx_n_s__IteratorRowAllRefs;
+static PyObject *__pyx_n_s__IteratorRowRegion;
+static PyObject *__pyx_n_s__IteratorSNPCalls;
+static PyObject *__pyx_n_s__KeyError;
+static PyObject *__pyx_n_s__LB;
+static PyObject *__pyx_n_s__LN;
+static PyObject *__pyx_n_s__M5;
+static PyObject *__pyx_n_s__NotImplementedError;
+static PyObject *__pyx_n_s__O_CREAT;
+static PyObject *__pyx_n_s__O_WRONLY;
+static PyObject *__pyx_n_s__Outs;
+static PyObject *__pyx_n_s__OverflowError;
+static PyObject *__pyx_n_s__PG;
+static PyObject *__pyx_n_s__PI;
+static PyObject *__pyx_n_s__PL;
+static PyObject *__pyx_n_s__PN;
+static PyObject *__pyx_n_s__PU;
+static PyObject *__pyx_n_s__PileupColumn;
+static PyObject *__pyx_n_s__PileupProxy;
+static PyObject *__pyx_n_s__PileupRead;
+static PyObject *__pyx_n_s__RG;
+static PyObject *__pyx_n_s__S;
+static PyObject *__pyx_n_s__SM;
+static PyObject *__pyx_n_s__SN;
+static PyObject *__pyx_n_s__SNPCaller;
+static PyObject *__pyx_n_s__SO;
+static PyObject *__pyx_n_s__SP;
+static PyObject *__pyx_n_s__SQ;
+static PyObject *__pyx_n_s__Samfile;
+static PyObject *__pyx_n_s__StderrStore;
+static PyObject *__pyx_n_s__StderrStoreWindows;
+static PyObject *__pyx_n_s__StopIteration;
+static PyObject *__pyx_n_s__TypeError;
+static PyObject *__pyx_n_s__UR;
+static PyObject *__pyx_n_s__VALID_HEADERS;
+static PyObject *__pyx_n_s__VALID_HEADER_FIELDS;
+static PyObject *__pyx_n_s__VALID_HEADER_ORDER;
+static PyObject *__pyx_n_s__VALID_HEADER_TYPES;
+static PyObject *__pyx_n_s__VN;
+static PyObject *__pyx_n_s__ValueError;
+static PyObject *__pyx_n_s__Windows;
+static PyObject *__pyx_n_s__Z;
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+static PyObject *__pyx_n_s____del__;
+static PyObject *__pyx_n_s____dict__;
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+static PyObject *__pyx_n_s____main__;
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+static PyObject *__pyx_n_s____str__;
+static PyObject *__pyx_n_s____test__;
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+static PyObject *__pyx_n_s___buildHeader;
+static PyObject *__pyx_n_s___buildLine;
+static PyObject *__pyx_n_s___call;
+static PyObject *__pyx_n_s___consensus_quality;
+static PyObject *__pyx_n_s___coverage;
+static PyObject *__pyx_n_s___delegate;
+static PyObject *__pyx_n_s___filename;
+static PyObject *__pyx_n_s___genotype;
+static PyObject *__pyx_n_s___hasIndex;
+static PyObject *__pyx_n_s___indel;
+static PyObject *__pyx_n_s___isOpen;
+static PyObject *__pyx_n_s___is_del;
+static PyObject *__pyx_n_s___is_head;
+static PyObject *__pyx_n_s___is_tail;
+static PyObject *__pyx_n_s___level;
+static PyObject *__pyx_n_s___logfile;
+static PyObject *__pyx_n_s___open;
+static PyObject *__pyx_n_s___parseRegion;
+static PyObject *__pyx_n_s___pos;
+static PyObject *__pyx_n_s___qpos;
+static PyObject *__pyx_n_s___r;
+static PyObject *__pyx_n_s___reference_base;
+static PyObject *__pyx_n_s___samtools_dispatch;
+static PyObject *__pyx_n_s___snp_quality;
+static PyObject *__pyx_n_s___tid;
+static PyObject *__pyx_n_s__addReference;
+static PyObject *__pyx_n_s__alignment;
+static PyObject *__pyx_n_s__all;
+static PyObject *__pyx_n_s__args;
+static PyObject *__pyx_n_s__b;
+static PyObject *__pyx_n_s__bam;
+static PyObject *__pyx_n_s__beg;
+static PyObject *__pyx_n_s__bin;
+static PyObject *__pyx_n_s__bqual;
+static PyObject *__pyx_n_s__build;
+static PyObject *__pyx_n_s__c;
+static PyObject *__pyx_n_s__calcsize;
+static PyObject *__pyx_n_s__call;
+static PyObject *__pyx_n_s__callback;
+static PyObject *__pyx_n_s__cap_mapQ;
+static PyObject *__pyx_n_s__catch_stderr;
+static PyObject *__pyx_n_s__catch_stdout;
+static PyObject *__pyx_n_s__chr;
+static PyObject *__pyx_n_s__cigar;
+static PyObject *__pyx_n_s__close;
+static PyObject *__pyx_n_s__cmp;
+static PyObject *__pyx_n_s__cnext;
+static PyObject *__pyx_n_s__cnt1;
+static PyObject *__pyx_n_s__cnt2;
+static PyObject *__pyx_n_s__cnt_anti;
+static PyObject *__pyx_n_s__collections;
+static PyObject *__pyx_n_s__compare;
+static PyObject *__pyx_n_s__consensus_quality;
+static PyObject *__pyx_n_s__core;
+static PyObject *__pyx_n_s__count;
+static PyObject *__pyx_n_s__coverage;
+static PyObject *__pyx_n_s__ctypes;
+static PyObject *__pyx_n_s__current_pos;
+static PyObject *__pyx_n_s__d;
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+static PyObject *__pyx_n_s__defaultdict;
+static PyObject *__pyx_n_s__devnull;
+static PyObject *__pyx_n_s__dup;
+static PyObject *__pyx_n_s__dup2;
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+static PyObject *__pyx_n_s__exc_type;
+static PyObject *__pyx_n_s__exc_value;
+static PyObject *__pyx_n_s__exists;
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+static PyObject *__pyx_n_s__fancy_str;
+static PyObject *__pyx_n_s__fastafile;
+static PyObject *__pyx_n_s__fd;
+static PyObject *__pyx_n_s__fetch;
+static PyObject *__pyx_n_s__fields;
+static PyObject *__pyx_n_s__filename;
+static PyObject *__pyx_n_s__fileno;
+static PyObject *__pyx_n_s__first_allele;
+static PyObject *__pyx_n_s__flag;
+static PyObject *__pyx_n_s__flush;
+static PyObject *__pyx_n_s__fp;
+static PyObject *__pyx_n_s__genotype;
+static PyObject *__pyx_n_s__getSequence;
+static PyObject *__pyx_n_s__getrname;
+static PyObject *__pyx_n_s__gettid;
+static PyObject *__pyx_n_s__hasReference;
+static PyObject *__pyx_n_s__hash;
+static PyObject *__pyx_n_s__header;
+static PyObject *__pyx_n_s__het_rate;
+static PyObject *__pyx_n_s__i;
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+static PyObject *__pyx_n_s__indel2;
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+static PyObject *__pyx_n_s__is_del;
+static PyObject *__pyx_n_s__is_head;
+static PyObject *__pyx_n_s__is_tail;
+static PyObject *__pyx_n_s__isbam;
+static PyObject *__pyx_n_s__isize;
+static PyObject *__pyx_n_s__isremote;
+static PyObject *__pyx_n_s__isupper;
+static PyObject *__pyx_n_s__iter;
+static PyObject *__pyx_n_s__iterator_column;
+static PyObject *__pyx_n_s__iterdata;
+static PyObject *__pyx_n_s__itertools;
+static PyObject *__pyx_n_s__join;
+static PyObject *__pyx_n_s__l_aux;
+static PyObject *__pyx_n_s__l_qname;
+static PyObject *__pyx_n_s__l_qseq;
+static PyObject *__pyx_n_s__l_text;
+static PyObject *__pyx_n_s__level;
+static PyObject *__pyx_n_s__m_data;
+static PyObject *__pyx_n_s__map;
+static PyObject *__pyx_n_s__mapping_quality;
+static PyObject *__pyx_n_s__mapq;
+static PyObject *__pyx_n_s__mask;
+static PyObject *__pyx_n_s__mate;
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+static PyObject *__pyx_n_s__method;
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+static PyObject *__pyx_n_s__mkstemp;
+static PyObject *__pyx_n_s__mode;
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+static PyObject *__pyx_n_s__mtid;
+static PyObject *__pyx_n_s__n;
+static PyObject *__pyx_n_s__n_cigar;
+static PyObject *__pyx_n_s__n_hap;
+static PyObject *__pyx_n_s__n_haplotypes;
+static PyObject *__pyx_n_s__n_plp;
+static PyObject *__pyx_n_s__n_pu;
+static PyObject *__pyx_n_s__n_targets;
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+static PyObject *__pyx_n_s__nreferences;
+static PyObject *__pyx_n_s__object;
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+static PyObject *__pyx_n_s__owns_samfile;
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+static PyObject *__pyx_n_s__path;
+static PyObject *__pyx_n_s__pileup;
+static PyObject *__pyx_n_s__pileup_iter;
+static PyObject *__pyx_n_s__pileups;
+static PyObject *__pyx_n_s__platform;
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+static PyObject *__pyx_n_s__port;
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+static PyObject *__pyx_n_s__q_r;
+static PyObject *__pyx_n_s__q_ref;
+static PyObject *__pyx_n_s__qname;
+static PyObject *__pyx_n_s__qpos;
+static PyObject *__pyx_n_s__qseq;
+static PyObject *__pyx_n_s__qual;
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+static PyObject *__pyx_n_s__range;
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+static PyObject *__pyx_n_s__rb;
+static PyObject *__pyx_n_s__re;
+static PyObject *__pyx_n_s__readAndRelease;
+static PyObject *__pyx_n_s__readlines;
+static PyObject *__pyx_n_s__reads_diff;
+static PyObject *__pyx_n_s__reads_first;
+static PyObject *__pyx_n_s__reads_second;
+static PyObject *__pyx_n_s__record;
+static PyObject *__pyx_n_s__reference;
+static PyObject *__pyx_n_s__reference_base;
+static PyObject *__pyx_n_s__referencelengths;
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+static int __pyx_setprop_9csamtools_11AlignedRead_is_paired(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_9is_paired___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_proper_pair(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_14is_proper_pair___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_proper_pair(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_14is_proper_pair___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_unmapped(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_11is_unmapped___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_unmapped(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_11is_unmapped___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_mate_is_unmapped(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_16mate_is_unmapped___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_mate_is_unmapped(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_16mate_is_unmapped___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_reverse(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_10is_reverse___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_reverse(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_10is_reverse___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_mate_is_reverse(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_15mate_is_reverse___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_mate_is_reverse(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_15mate_is_reverse___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_read1(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_8is_read1___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_read1(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_8is_read1___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_read2(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_8is_read2___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_read2(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_8is_read2___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_secondary(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_12is_secondary___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_secondary(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_12is_secondary___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_qcfail(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_9is_qcfail___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_qcfail(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_9is_qcfail___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_is_duplicate(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_12is_duplicate___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11AlignedRead_is_duplicate(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11AlignedRead_12is_duplicate___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11AlignedRead_positions(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11AlignedRead_9positions___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_AlignedRead[] = {
+ {__Pyx_NAMESTR("compare"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_compare, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_compare)},
+ {__Pyx_NAMESTR("overlap"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_overlap, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_overlap)},
+ {__Pyx_NAMESTR("opt"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_opt, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_opt)},
+ {__Pyx_NAMESTR("fancy_str"), (PyCFunction)__pyx_pf_9csamtools_11AlignedRead_fancy_str, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_11AlignedRead_fancy_str)},
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_AlignedRead[] = {
+ {(char *)"qname", __pyx_getprop_9csamtools_11AlignedRead_qname, __pyx_setprop_9csamtools_11AlignedRead_qname, __Pyx_DOCSTR(__pyx_k_114), 0},
+ {(char *)"cigar", __pyx_getprop_9csamtools_11AlignedRead_cigar, __pyx_setprop_9csamtools_11AlignedRead_cigar, __Pyx_DOCSTR(__pyx_k_115), 0},
+ {(char *)"seq", __pyx_getprop_9csamtools_11AlignedRead_seq, __pyx_setprop_9csamtools_11AlignedRead_seq, __Pyx_DOCSTR(__pyx_k_116), 0},
+ {(char *)"qual", __pyx_getprop_9csamtools_11AlignedRead_qual, __pyx_setprop_9csamtools_11AlignedRead_qual, __Pyx_DOCSTR(__pyx_k_117), 0},
+ {(char *)"query", __pyx_getprop_9csamtools_11AlignedRead_query, 0, __Pyx_DOCSTR(__pyx_k_118), 0},
+ {(char *)"qqual", __pyx_getprop_9csamtools_11AlignedRead_qqual, 0, __Pyx_DOCSTR(__pyx_k_119), 0},
+ {(char *)"qstart", __pyx_getprop_9csamtools_11AlignedRead_qstart, 0, __Pyx_DOCSTR(__pyx_k_120), 0},
+ {(char *)"qend", __pyx_getprop_9csamtools_11AlignedRead_qend, 0, __Pyx_DOCSTR(__pyx_k_121), 0},
+ {(char *)"qlen", __pyx_getprop_9csamtools_11AlignedRead_qlen, 0, __Pyx_DOCSTR(__pyx_k_122), 0},
+ {(char *)"tags", __pyx_getprop_9csamtools_11AlignedRead_tags, __pyx_setprop_9csamtools_11AlignedRead_tags, __Pyx_DOCSTR(__pyx_k_123), 0},
+ {(char *)"flag", __pyx_getprop_9csamtools_11AlignedRead_flag, __pyx_setprop_9csamtools_11AlignedRead_flag, __Pyx_DOCSTR(__pyx_k_124), 0},
+ {(char *)"rname", __pyx_getprop_9csamtools_11AlignedRead_rname, __pyx_setprop_9csamtools_11AlignedRead_rname, __Pyx_DOCSTR(__pyx_k_125), 0},
+ {(char *)"tid", __pyx_getprop_9csamtools_11AlignedRead_tid, __pyx_setprop_9csamtools_11AlignedRead_tid, __Pyx_DOCSTR(__pyx_k_126), 0},
+ {(char *)"pos", __pyx_getprop_9csamtools_11AlignedRead_pos, __pyx_setprop_9csamtools_11AlignedRead_pos, __Pyx_DOCSTR(__pyx_k_127), 0},
+ {(char *)"bin", __pyx_getprop_9csamtools_11AlignedRead_bin, __pyx_setprop_9csamtools_11AlignedRead_bin, __Pyx_DOCSTR(__pyx_k_128), 0},
+ {(char *)"rlen", __pyx_getprop_9csamtools_11AlignedRead_rlen, 0, __Pyx_DOCSTR(__pyx_k_129), 0},
+ {(char *)"aend", __pyx_getprop_9csamtools_11AlignedRead_aend, 0, __Pyx_DOCSTR(__pyx_k_130), 0},
+ {(char *)"alen", __pyx_getprop_9csamtools_11AlignedRead_alen, 0, __Pyx_DOCSTR(__pyx_k_131), 0},
+ {(char *)"mapq", __pyx_getprop_9csamtools_11AlignedRead_mapq, __pyx_setprop_9csamtools_11AlignedRead_mapq, __Pyx_DOCSTR(__pyx_k_132), 0},
+ {(char *)"mrnm", __pyx_getprop_9csamtools_11AlignedRead_mrnm, __pyx_setprop_9csamtools_11AlignedRead_mrnm, __Pyx_DOCSTR(__pyx_k_133), 0},
+ {(char *)"mpos", __pyx_getprop_9csamtools_11AlignedRead_mpos, __pyx_setprop_9csamtools_11AlignedRead_mpos, __Pyx_DOCSTR(__pyx_k_134), 0},
+ {(char *)"isize", __pyx_getprop_9csamtools_11AlignedRead_isize, __pyx_setprop_9csamtools_11AlignedRead_isize, __Pyx_DOCSTR(__pyx_k_135), 0},
+ {(char *)"is_paired", __pyx_getprop_9csamtools_11AlignedRead_is_paired, __pyx_setprop_9csamtools_11AlignedRead_is_paired, __Pyx_DOCSTR(__pyx_k_136), 0},
+ {(char *)"is_proper_pair", __pyx_getprop_9csamtools_11AlignedRead_is_proper_pair, __pyx_setprop_9csamtools_11AlignedRead_is_proper_pair, __Pyx_DOCSTR(__pyx_k_137), 0},
+ {(char *)"is_unmapped", __pyx_getprop_9csamtools_11AlignedRead_is_unmapped, __pyx_setprop_9csamtools_11AlignedRead_is_unmapped, __Pyx_DOCSTR(__pyx_k_138), 0},
+ {(char *)"mate_is_unmapped", __pyx_getprop_9csamtools_11AlignedRead_mate_is_unmapped, __pyx_setprop_9csamtools_11AlignedRead_mate_is_unmapped, __Pyx_DOCSTR(__pyx_k_139), 0},
+ {(char *)"is_reverse", __pyx_getprop_9csamtools_11AlignedRead_is_reverse, __pyx_setprop_9csamtools_11AlignedRead_is_reverse, __Pyx_DOCSTR(__pyx_k_140), 0},
+ {(char *)"mate_is_reverse", __pyx_getprop_9csamtools_11AlignedRead_mate_is_reverse, __pyx_setprop_9csamtools_11AlignedRead_mate_is_reverse, __Pyx_DOCSTR(__pyx_k_141), 0},
+ {(char *)"is_read1", __pyx_getprop_9csamtools_11AlignedRead_is_read1, __pyx_setprop_9csamtools_11AlignedRead_is_read1, __Pyx_DOCSTR(__pyx_k_142), 0},
+ {(char *)"is_read2", __pyx_getprop_9csamtools_11AlignedRead_is_read2, __pyx_setprop_9csamtools_11AlignedRead_is_read2, __Pyx_DOCSTR(__pyx_k_143), 0},
+ {(char *)"is_secondary", __pyx_getprop_9csamtools_11AlignedRead_is_secondary, __pyx_setprop_9csamtools_11AlignedRead_is_secondary, __Pyx_DOCSTR(__pyx_k_144), 0},
+ {(char *)"is_qcfail", __pyx_getprop_9csamtools_11AlignedRead_is_qcfail, __pyx_setprop_9csamtools_11AlignedRead_is_qcfail, __Pyx_DOCSTR(__pyx_k_145), 0},
+ {(char *)"is_duplicate", __pyx_getprop_9csamtools_11AlignedRead_is_duplicate, __pyx_setprop_9csamtools_11AlignedRead_is_duplicate, __Pyx_DOCSTR(__pyx_k_146), 0},
+ {(char *)"positions", __pyx_getprop_9csamtools_11AlignedRead_positions, 0, __Pyx_DOCSTR(__pyx_k_147), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_AlignedRead = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_AlignedRead = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_AlignedRead = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_AlignedRead = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_AlignedRead = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.AlignedRead"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_AlignedRead), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_AlignedRead, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_AlignedRead, /*tp_as_number*/
+ &__pyx_tp_as_sequence_AlignedRead, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_AlignedRead, /*tp_as_mapping*/
+ __pyx_pf_9csamtools_11AlignedRead___hash__, /*tp_hash*/
+ 0, /*tp_call*/
+ __pyx_pf_9csamtools_11AlignedRead___str__, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_AlignedRead, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("AlignedRead()\n\n Class representing an aligned read. see SAM format specification for \n the meaning of fields (http://samtools.sourceforge.net/).\n\n This class stores a handle to the samtools C-structure representing\n an aligned read. Member read access is forwarded to the C-structure\n and converted into python objects. This implementation should be fast,\n as only the data needed is converted.\n\n For write access, the C-structure is updated in-place. This is\n not the most efficient way to build BAM entries, as the variable\n length data is concatenated and thus needs to resized if\n a field is updated. Furthermore, the BAM entry might be\n in an inconsistent state. The :meth:`~validate` method can\n be used to check if an entry is consistent.\n\n One issue to look out for is that the sequence should always\n be set *before* the quality scores. Setting the sequence will\n also erase any quality scores that were set previously.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_9csamtools_AlignedRead, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_9csamtools_AlignedRead, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ __pyx_pf_9csamtools_11AlignedRead___init__, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_AlignedRead, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_Samfile __pyx_vtable_9csamtools_Samfile;
+
+static PyObject *__pyx_tp_new_9csamtools_Samfile(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_Samfile *p;
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_Samfile *)o);
+ p->__pyx_vtab = __pyx_vtabptr_9csamtools_Samfile;
+ if (__pyx_pf_9csamtools_7Samfile___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_Samfile(PyObject *o) {
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_9csamtools_7Samfile___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_filename(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_8filename___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_nreferences(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_11nreferences___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_references(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_10references___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_lengths(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_7lengths___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_text(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_4text___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7Samfile_header(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7Samfile_6header___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_Samfile[] = {
+ {__Pyx_NAMESTR("_isOpen"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__isOpen, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__isOpen)},
+ {__Pyx_NAMESTR("_hasIndex"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__hasIndex, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__hasIndex)},
+ {__Pyx_NAMESTR("_open"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__open, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__open)},
+ {__Pyx_NAMESTR("gettid"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_gettid, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_gettid)},
+ {__Pyx_NAMESTR("getrname"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_getrname, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_getrname)},
+ {__Pyx_NAMESTR("_parseRegion"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__parseRegion, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__parseRegion)},
+ {__Pyx_NAMESTR("seek"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_seek, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_seek)},
+ {__Pyx_NAMESTR("tell"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_tell, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_tell)},
+ {__Pyx_NAMESTR("fetch"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_fetch, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_fetch)},
+ {__Pyx_NAMESTR("mate"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_mate, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_mate)},
+ {__Pyx_NAMESTR("count"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_count, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_count)},
+ {__Pyx_NAMESTR("pileup"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_pileup, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_pileup)},
+ {__Pyx_NAMESTR("close"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_close, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_close)},
+ {__Pyx_NAMESTR("write"), (PyCFunction)__pyx_pf_9csamtools_7Samfile_write, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile_write)},
+ {__Pyx_NAMESTR("__enter__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___enter__, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___enter__)},
+ {__Pyx_NAMESTR("__exit__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___exit__, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___exit__)},
+ {__Pyx_NAMESTR("_buildLine"), (PyCFunction)__pyx_pf_9csamtools_7Samfile__buildLine, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile__buildLine)},
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_7Samfile___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_7Samfile___next__)},
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_Samfile[] = {
+ {(char *)"filename", __pyx_getprop_9csamtools_7Samfile_filename, 0, __Pyx_DOCSTR(__pyx_k_148), 0},
+ {(char *)"nreferences", __pyx_getprop_9csamtools_7Samfile_nreferences, 0, __Pyx_DOCSTR(__pyx_k_149), 0},
+ {(char *)"references", __pyx_getprop_9csamtools_7Samfile_references, 0, __Pyx_DOCSTR(__pyx_k_150), 0},
+ {(char *)"lengths", __pyx_getprop_9csamtools_7Samfile_lengths, 0, __Pyx_DOCSTR(__pyx_k_151), 0},
+ {(char *)"text", __pyx_getprop_9csamtools_7Samfile_text, 0, __Pyx_DOCSTR(__pyx_k_152), 0},
+ {(char *)"header", __pyx_getprop_9csamtools_7Samfile_header, 0, __Pyx_DOCSTR(__pyx_k_153), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_Samfile = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_Samfile = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_Samfile = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_Samfile = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_Samfile = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.Samfile"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_Samfile), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_Samfile, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_Samfile, /*tp_as_number*/
+ &__pyx_tp_as_sequence_Samfile, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_Samfile, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_Samfile, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("*(filename, mode=None, template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*\n \n A :term:`SAM`/:term:`BAM` formatted file. The file is automatically opened.\n \n *mode* should be ``r`` for reading or ``w`` for writing. The default is text mode (:term:`SAM`). For binary \n (:term:`BAM`) I/O you should append ``b`` for compressed or ``u`` for uncompressed :term:`BAM` output. \n Use ``h`` to output header information in text (:term:`TAM`) mode.\n\n If ``b`` is present, it must immediately follow ``r`` or ``w``. \n Valid modes are ``r``, ``w``, ``wh``, ``rb``, ``wb`` and ``wbu``. For instance, to open \n a :term:`BAM` formatted file for reading, type::\n\n f = pysam.Samfile('ex1.bam','rb')\n\n If mode is not specified, we will try to auto-detect in the order 'r', 'rb', thus both the following\n should work::\n\n f1 = pysam.Samfile('ex1.bam' )\n f2 = pysam.Samfile('ex1.bam' )\n\n If an index for a BAM file exists (.bai), it will be opened automatically. Without an index random\n access to reads via :meth:`fetch` and :meth:`pileup` is disabled.\n\n For writing, the header of a :term:`SAM` file/:term:`BAM` file can be constituted from several\n sources (see also the samtools format specification):\n\n 1. If *template* is given, the header is copied from a another *Samfile* \n (*template* must be of type *Samfile*).\n\n 2. If *header* is given, the header is built from a multi-level dictionary. The first level \n are the four types ('HD', 'SQ', ...). The second level are a list of lines, with each line \n being a list of tag-value pairs.\n\n 3. If *text* is given, new header text is copied from raw text.\n\n 4. The names (*referencenames*) and lengths (*referencelengths*) are supplied directly as lists. \n\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_7Samfile___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_7Samfile___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_Samfile, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_9csamtools_Samfile, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_Samfile, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_9csamtools_PileupProxy(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_PileupProxy(PyObject *o) {
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_11PileupProxy_tid(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11PileupProxy_3tid___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_11PileupProxy_n(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11PileupProxy_1n___get__(o);
+}
+
+static int __pyx_setprop_9csamtools_11PileupProxy_n(PyObject *o, PyObject *v, void *x) {
+ if (v) {
+ return __pyx_pf_9csamtools_11PileupProxy_1n___set__(o, v);
+ }
+ else {
+ PyErr_SetString(PyExc_NotImplementedError, "__del__");
+ return -1;
+ }
+}
+
+static PyObject *__pyx_getprop_9csamtools_11PileupProxy_pos(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11PileupProxy_3pos___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_11PileupProxy_pileups(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_11PileupProxy_7pileups___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_PileupProxy[] = {
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_PileupProxy[] = {
+ {(char *)"tid", __pyx_getprop_9csamtools_11PileupProxy_tid, 0, __Pyx_DOCSTR(__pyx_k_154), 0},
+ {(char *)"n", __pyx_getprop_9csamtools_11PileupProxy_n, __pyx_setprop_9csamtools_11PileupProxy_n, __Pyx_DOCSTR(__pyx_k_155), 0},
+ {(char *)"pos", __pyx_getprop_9csamtools_11PileupProxy_pos, 0, 0, 0},
+ {(char *)"pileups", __pyx_getprop_9csamtools_11PileupProxy_pileups, 0, __Pyx_DOCSTR(__pyx_k_156), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_PileupProxy = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_PileupProxy = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_PileupProxy = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_PileupProxy = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_PileupProxy = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.PileupProxy"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_PileupProxy), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_PileupProxy, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_PileupProxy, /*tp_as_number*/
+ &__pyx_tp_as_sequence_PileupProxy, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_PileupProxy, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ __pyx_pf_9csamtools_11PileupProxy___str__, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_PileupProxy, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("PileupProxy()\nA pileup column. A pileup column contains\n all the reads that map to a certain target base.\n\n tid\n chromosome ID as is defined in the header\n pos\n the target base coordinate (0-based)\n n\n number of reads mapping to this column \n pileups\n list of reads (:class:`pysam.PileupRead`) aligned to this column\n\n This class is a proxy for results returned by the samtools pileup engine.\n If the underlying engine iterator advances, the results of this column\n will change.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_9csamtools_PileupProxy, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_9csamtools_PileupProxy, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ __pyx_pf_9csamtools_11PileupProxy___init__, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_PileupProxy, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_9csamtools_PileupRead(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_PileupRead *p;
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_PileupRead *)o);
+ p->_alignment = ((struct __pyx_obj_9csamtools_AlignedRead *)Py_None); Py_INCREF(Py_None);
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_PileupRead(PyObject *o) {
+ struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
+ Py_XDECREF(((PyObject *)p->_alignment));
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_PileupRead(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
+ if (p->_alignment) {
+ e = (*v)(((PyObject*)p->_alignment), a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_PileupRead(PyObject *o) {
+ struct __pyx_obj_9csamtools_PileupRead *p = (struct __pyx_obj_9csamtools_PileupRead *)o;
+ PyObject* tmp;
+ tmp = ((PyObject*)p->_alignment);
+ p->_alignment = ((struct __pyx_obj_9csamtools_AlignedRead *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_alignment(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_9alignment___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_qpos(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_4qpos___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_indel(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_5indel___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_del(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_6is_del___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_head(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_7is_head___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_is_tail(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_7is_tail___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_10PileupRead_level(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_10PileupRead_5level___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_PileupRead[] = {
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_PileupRead[] = {
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+ {(char *)"qpos", __pyx_getprop_9csamtools_10PileupRead_qpos, 0, __Pyx_DOCSTR(__pyx_k_158), 0},
+ {(char *)"indel", __pyx_getprop_9csamtools_10PileupRead_indel, 0, __Pyx_DOCSTR(__pyx_k_159), 0},
+ {(char *)"is_del", __pyx_getprop_9csamtools_10PileupRead_is_del, 0, __Pyx_DOCSTR(__pyx_k_160), 0},
+ {(char *)"is_head", __pyx_getprop_9csamtools_10PileupRead_is_head, 0, 0, 0},
+ {(char *)"is_tail", __pyx_getprop_9csamtools_10PileupRead_is_tail, 0, 0, 0},
+ {(char *)"level", __pyx_getprop_9csamtools_10PileupRead_level, 0, 0, 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_PileupRead = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
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+}
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+}
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+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
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+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("abstract base class for iterators over mapped reads.\n\n Various iterators implement different behaviours for wrapping around\n contig boundaries. Examples include:\n\n :class:`pysam.IteratorRowRegion`\n iterate within a single contig and a defined region.\n\n :class:`pysam.IteratorRowAll`\n iterate until EOF. This iterator will also include unmapped reads.\n\n :class:`pysam.IteratorRowAllRefs`\n iterate over all reads in all reference sequences.\n \n The method :meth:`Samfile.fetch` returns an IteratorRow.\n "), /*tp_doc*/
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+ 0, /*tp_version_tag*/
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+}
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+}
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+static int __pyx_tp_traverse_9csamtools_IteratorRowRegion(PyObject *o, visitproc v, void *a) {
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+}
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+static int __pyx_tp_clear_9csamtools_IteratorRowRegion(PyObject *o) {
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+}
+
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
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+ 0, /*nb_inplace_power*/
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+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorRowRegion = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
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+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorRowRegion = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorRowRegion = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorRowRegion = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorRowRegion"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorRowRegion), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorRowRegion, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorRowRegion, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorRowRegion, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorRowRegion, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorRowRegion, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("*(Samfile samfile, int tid, int beg, int end, int reopen = True )*\n\n iterate over mapped reads in a region.\n\n By default, the file is re-openend to avoid conflicts between\n multiple iterators working on the same file. Set *reopen* = False\n to not re-open *samfile*.\n\n The samtools iterators assume that the file\n position between iterations do not change.\n As a consequence, no two iterators can work\n on the same file. To permit this, each iterator\n creates its own file handle by re-opening the\n file.\n\n Note that the index will be shared between \n samfile and the iterator.\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorRowRegion, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorRowRegion, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_17IteratorRowRegion___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_17IteratorRowRegion___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorRowRegion, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IteratorRowRegion, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorRowAll __pyx_vtable_9csamtools_IteratorRowAll;
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorRowAll(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorRowAll *p;
+ PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorRowAll *)o);
+ p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorRowAll;
+ if (__pyx_pf_9csamtools_14IteratorRowAll___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_IteratorRowAll(PyObject *o) {
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_9csamtools_14IteratorRowAll___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ __pyx_tp_dealloc_9csamtools_IteratorRow(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorRowAll[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_14IteratorRowAll___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorRowAll___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_IteratorRowAll = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
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+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorRowAll = {
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+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorRowAll = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorRowAll = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorRowAll = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorRowAll"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorRowAll), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorRowAll, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorRowAll, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorRowAll, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorRowAll, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorRowAll, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("*(Samfile samfile, int reopen = True)*\n\n iterate over all reads in *samfile*\n\n By default, the file is re-openend to avoid conflicts between\n multiple iterators working on the same file. Set *reopen* = False\n to not re-open *samfile*.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_14IteratorRowAll___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_14IteratorRowAll___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorRowAll, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
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+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
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+ __pyx_tp_new_9csamtools_IteratorRowAll, /*tp_new*/
+ 0, /*tp_free*/
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+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorRowAllRefs(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorRowAllRefs *p;
+ PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ p->rowiter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
+ if (__pyx_pf_9csamtools_18IteratorRowAllRefs___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_IteratorRowAllRefs(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
+ Py_XDECREF(((PyObject *)p->samfile));
+ Py_XDECREF(((PyObject *)p->rowiter));
+ __pyx_tp_dealloc_9csamtools_IteratorRow(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_IteratorRowAllRefs(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
+ if (__pyx_ptype_9csamtools_IteratorRow->tp_traverse) {
+ e = __pyx_ptype_9csamtools_IteratorRow->tp_traverse(o, v, a); if (e) return e;
+ }
+ if (p->samfile) {
+ e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
+ }
+ if (p->rowiter) {
+ e = (*v)(((PyObject*)p->rowiter), a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_IteratorRowAllRefs(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorRowAllRefs *p = (struct __pyx_obj_9csamtools_IteratorRowAllRefs *)o;
+ PyObject* tmp;
+ if (__pyx_ptype_9csamtools_IteratorRow->tp_clear) {
+ __pyx_ptype_9csamtools_IteratorRow->tp_clear(o);
+ }
+ tmp = ((PyObject*)p->samfile);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ tmp = ((PyObject*)p->rowiter);
+ p->rowiter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorRowAllRefs[] = {
+ {__Pyx_NAMESTR("nextiter"), (PyCFunction)__pyx_pf_9csamtools_18IteratorRowAllRefs_nextiter, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_18IteratorRowAllRefs_nextiter)},
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_18IteratorRowAllRefs___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_18IteratorRowAllRefs___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_IteratorRowAllRefs = {
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
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+ 0, /*nb_xor*/
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+ 0, /*nb_coerce*/
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
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+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
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+ 0, /*nb_inplace_xor*/
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+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorRowAllRefs = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorRowAllRefs = {
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+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorRowAllRefs = {
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+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorRowAllRefs = {
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+ __Pyx_NAMESTR("csamtools.IteratorRowAllRefs"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorRowAllRefs), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorRowAllRefs, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorRowAllRefs, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorRowAllRefs, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorRowAllRefs, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorRowAllRefs, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("iterates over all mapped reads by chaining iterators over each reference\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorRowAllRefs, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorRowAllRefs, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_18IteratorRowAllRefs___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_18IteratorRowAllRefs___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorRowAllRefs, /*tp_methods*/
+ 0, /*tp_members*/
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+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IteratorRowAllRefs, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorRowSelection __pyx_vtable_9csamtools_IteratorRowSelection;
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorRowSelection(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorRowSelection *p;
+ PyObject *o = __pyx_tp_new_9csamtools_IteratorRow(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorRowSelection *)o);
+ p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorRowSelection;
+ p->positions = Py_None; Py_INCREF(Py_None);
+ if (__pyx_pf_9csamtools_20IteratorRowSelection___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_IteratorRowSelection(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_9csamtools_20IteratorRowSelection___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ Py_XDECREF(p->positions);
+ __pyx_tp_dealloc_9csamtools_IteratorRow(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_IteratorRowSelection(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
+ if (__pyx_ptype_9csamtools_IteratorRow->tp_traverse) {
+ e = __pyx_ptype_9csamtools_IteratorRow->tp_traverse(o, v, a); if (e) return e;
+ }
+ if (p->positions) {
+ e = (*v)(p->positions, a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_IteratorRowSelection(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorRowSelection *p = (struct __pyx_obj_9csamtools_IteratorRowSelection *)o;
+ PyObject* tmp;
+ if (__pyx_ptype_9csamtools_IteratorRow->tp_clear) {
+ __pyx_ptype_9csamtools_IteratorRow->tp_clear(o);
+ }
+ tmp = ((PyObject*)p->positions);
+ p->positions = Py_None; Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorRowSelection[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_20IteratorRowSelection___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_20IteratorRowSelection___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_IteratorRowSelection = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
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+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorRowSelection = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorRowSelection = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorRowSelection = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorRowSelection = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorRowSelection"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorRowSelection), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorRowSelection, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorRowSelection, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorRowSelection, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorRowSelection, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorRowSelection, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("*(Samfile samfile)*\n\n iterate over reads in *samfile* at a given list of file positions.\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorRowSelection, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorRowSelection, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_20IteratorRowSelection___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_20IteratorRowSelection___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorRowSelection, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IteratorRowSelection, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorColumn __pyx_vtable_9csamtools_IteratorColumn;
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorColumn(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorColumn *p;
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorColumn *)o);
+ p->__pyx_vtab = __pyx_vtabptr_9csamtools_IteratorColumn;
+ p->iter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ p->fastafile = ((struct __pyx_obj_9csamtools_Fastafile *)Py_None); Py_INCREF(Py_None);
+ p->stepper = Py_None; Py_INCREF(Py_None);
+ if (__pyx_pf_9csamtools_14IteratorColumn___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_IteratorColumn(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_9csamtools_14IteratorColumn___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ Py_XDECREF(((PyObject *)p->iter));
+ Py_XDECREF(((PyObject *)p->samfile));
+ Py_XDECREF(((PyObject *)p->fastafile));
+ Py_XDECREF(p->stepper);
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_IteratorColumn(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
+ if (p->iter) {
+ e = (*v)(((PyObject*)p->iter), a); if (e) return e;
+ }
+ if (p->samfile) {
+ e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
+ }
+ if (p->fastafile) {
+ e = (*v)(((PyObject*)p->fastafile), a); if (e) return e;
+ }
+ if (p->stepper) {
+ e = (*v)(p->stepper, a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_IteratorColumn(PyObject *o) {
+ struct __pyx_obj_9csamtools_IteratorColumn *p = (struct __pyx_obj_9csamtools_IteratorColumn *)o;
+ PyObject* tmp;
+ tmp = ((PyObject*)p->iter);
+ p->iter = ((struct __pyx_obj_9csamtools_IteratorRowRegion *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ tmp = ((PyObject*)p->samfile);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ tmp = ((PyObject*)p->fastafile);
+ p->fastafile = ((struct __pyx_obj_9csamtools_Fastafile *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ tmp = ((PyObject*)p->stepper);
+ p->stepper = Py_None; Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyObject *__pyx_getprop_9csamtools_14IteratorColumn_seq_len(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_14IteratorColumn_7seq_len___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorColumn[] = {
+ {__Pyx_NAMESTR("addReference"), (PyCFunction)__pyx_pf_9csamtools_14IteratorColumn_addReference, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorColumn_addReference)},
+ {__Pyx_NAMESTR("hasReference"), (PyCFunction)__pyx_pf_9csamtools_14IteratorColumn_hasReference, METH_NOARGS, __Pyx_DOCSTR(__pyx_doc_9csamtools_14IteratorColumn_hasReference)},
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_IteratorColumn[] = {
+ {(char *)"seq_len", __pyx_getprop_9csamtools_14IteratorColumn_seq_len, 0, __Pyx_DOCSTR(__pyx_k_161), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_IteratorColumn = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
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+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorColumn = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorColumn = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorColumn = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorColumn = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorColumn"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorColumn), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorColumn, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorColumn, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorColumn, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorColumn, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("abstract base class for iterators over columns.\n\n IteratorColumn objects wrap the pileup functionality of samtools.\n \n For reasons of efficiency, the iterator points to the current \n pileup buffer. The pileup buffer is updated at every iteration.\n This might cause some unexpected behavious. For example,\n consider the conversion to a list::\n \n f = Samfile(\"file.bam\", \"rb\")\n result = list( f.pileup() )\n\n Here, ``result`` will contain ``n`` objects of type :class:`PileupProxy` for ``n`` columns, \n but each object in ``result`` will contain the same information.\n \n The desired behaviour can be achieved by list comprehension::\n\n result = [ x.pileups() for x in f.pileup() ]\n\n ``result`` will be a list of ``n`` lists of objects of type :class:`PileupRead`.\n\n If the iterator is associated with a :class:`Fastafile` using the :meth:`addReference`\n method, then the iterator will export the current sequence via the methods :meth:`getSequence`\n and :meth:`seq_len`.\n\n Optional kwargs to the iterator\n\n stepper\n The stepper controlls how the iterator advances. \n Possible options for the stepper are \n \n all\n use all reads for pileup.\n samtools\n same filter and read processing as in :term:`csamtools` pileup\n fastafile\n A :class:`FastaFile` object\n mask\n Skip all reads with bits set in mask.\n \n \n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_14IteratorColumn___iter__, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorColumn, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_9csamtools_IteratorColumn, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IteratorColumn, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorColumnRegion __pyx_vtable_9csamtools_IteratorColumnRegion;
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorColumnRegion(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorColumnRegion *p;
+ PyObject *o = __pyx_tp_new_9csamtools_IteratorColumn(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorColumnRegion *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_IteratorColumn*)__pyx_vtabptr_9csamtools_IteratorColumnRegion;
+ if (__pyx_pf_9csamtools_20IteratorColumnRegion___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorColumnRegion[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_20IteratorColumnRegion___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_20IteratorColumnRegion___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_IteratorColumnRegion = {
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
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+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
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+ #if PY_MAJOR_VERSION < 3
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+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
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+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorColumnRegion = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorColumnRegion = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorColumnRegion = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorColumnRegion = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorColumnRegion"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorColumnRegion), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorColumnRegion, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorColumnRegion, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorColumnRegion, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorColumnRegion, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("iterates over a region only.\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ __pyx_pf_9csamtools_20IteratorColumnRegion___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorColumnRegion, /*tp_methods*/
+ 0, /*tp_members*/
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+ __pyx_tp_new_9csamtools_IteratorColumnRegion, /*tp_new*/
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+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
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+
+static PyObject *__pyx_tp_new_9csamtools_IteratorColumnAllRefs(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorColumnAllRefs *p;
+ PyObject *o = __pyx_tp_new_9csamtools_IteratorColumn(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorColumnAllRefs *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_IteratorColumn*)__pyx_vtabptr_9csamtools_IteratorColumnAllRefs;
+ if (__pyx_pf_9csamtools_21IteratorColumnAllRefs___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorColumnAllRefs[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_21IteratorColumnAllRefs___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_21IteratorColumnAllRefs___next__)},
+ {0, 0, 0, 0}
+};
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
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+ #endif
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+ #if PY_MAJOR_VERSION < 3
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+ #endif
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+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorColumnAllRefs = {
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+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorColumnAllRefs = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorColumnAllRefs = {
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+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorColumnAllRefs = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorColumnAllRefs"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorColumnAllRefs), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_IteratorColumn, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorColumnAllRefs, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorColumnAllRefs, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorColumnAllRefs, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorColumnAllRefs, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("iterates over all columns by chaining iterators over each reference\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_IteratorColumn, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_IteratorColumn, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ __pyx_pf_9csamtools_21IteratorColumnAllRefs___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorColumnAllRefs, /*tp_methods*/
+ 0, /*tp_members*/
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+ __pyx_tp_new_9csamtools_IteratorColumnAllRefs, /*tp_new*/
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+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_9csamtools_SNPCall(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_SNPCall(PyObject *o) {
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_tid(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_3tid___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_pos(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_3pos___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_reference_base(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_14reference_base___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_genotype(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_8genotype___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_consensus_quality(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_17consensus_quality___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_snp_quality(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_11snp_quality___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_mapping_quality(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_15mapping_quality___get__(o);
+}
+
+static PyObject *__pyx_getprop_9csamtools_7SNPCall_coverage(PyObject *o, void *x) {
+ return __pyx_pf_9csamtools_7SNPCall_8coverage___get__(o);
+}
+
+static PyMethodDef __pyx_methods_9csamtools_SNPCall[] = {
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_9csamtools_SNPCall[] = {
+ {(char *)"tid", __pyx_getprop_9csamtools_7SNPCall_tid, 0, __Pyx_DOCSTR(__pyx_k_154), 0},
+ {(char *)"pos", __pyx_getprop_9csamtools_7SNPCall_pos, 0, __Pyx_DOCSTR(__pyx_k_162), 0},
+ {(char *)"reference_base", __pyx_getprop_9csamtools_7SNPCall_reference_base, 0, __Pyx_DOCSTR(__pyx_k_163), 0},
+ {(char *)"genotype", __pyx_getprop_9csamtools_7SNPCall_genotype, 0, __Pyx_DOCSTR(__pyx_k_164), 0},
+ {(char *)"consensus_quality", __pyx_getprop_9csamtools_7SNPCall_consensus_quality, 0, __Pyx_DOCSTR(__pyx_k_165), 0},
+ {(char *)"snp_quality", __pyx_getprop_9csamtools_7SNPCall_snp_quality, 0, __Pyx_DOCSTR(__pyx_k_166), 0},
+ {(char *)"mapping_quality", __pyx_getprop_9csamtools_7SNPCall_mapping_quality, 0, __Pyx_DOCSTR(__pyx_k_167), 0},
+ {(char *)"coverage", __pyx_getprop_9csamtools_7SNPCall_coverage, 0, __Pyx_DOCSTR(__pyx_k_168), 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_SNPCall = {
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
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+ 0, /*nb_float*/
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+ #endif
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+ #endif
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+ 0, /*nb_inplace_subtract*/
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
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+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
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+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
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+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_SNPCall = {
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+ 0, /*sq_concat*/
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+};
+
+static PyMappingMethods __pyx_tp_as_mapping_SNPCall = {
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+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_SNPCall = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
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+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_SNPCall, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_SNPCall, /*tp_as_number*/
+ &__pyx_tp_as_sequence_SNPCall, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_SNPCall, /*tp_as_mapping*/
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+ 0, /*tp_call*/
+ __pyx_pf_9csamtools_7SNPCall___str__, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_SNPCall, /*tp_as_buffer*/
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+ __Pyx_DOCSTR("the results of a SNP call."), /*tp_doc*/
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+ 0, /*tp_iternext*/
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+ __pyx_getsets_9csamtools_SNPCall, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_SNPCall, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
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+
+static PyObject *__pyx_tp_new_9csamtools_SNPCallerBase(PyTypeObject *t, PyObject *a, PyObject *k) {
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+ PyObject *o = (*t->tp_alloc)(t, 0);
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+ p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
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+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_SNPCallerBase(PyObject *o) {
+ struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
+ {
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+ __pyx_pf_9csamtools_13SNPCallerBase___dealloc__(o);
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+ PyErr_Restore(etype, eval, etb);
+ }
+ Py_XDECREF(((PyObject *)p->iter));
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_SNPCallerBase(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
+ if (p->iter) {
+ e = (*v)(((PyObject*)p->iter), a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_SNPCallerBase(PyObject *o) {
+ struct __pyx_obj_9csamtools_SNPCallerBase *p = (struct __pyx_obj_9csamtools_SNPCallerBase *)o;
+ PyObject* tmp;
+ tmp = ((PyObject*)p->iter);
+ p->iter = ((struct __pyx_obj_9csamtools_IteratorColumn *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_SNPCallerBase[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_SNPCallerBase = {
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
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+ #if PY_MAJOR_VERSION < 3
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+ 0, /*nb_int*/
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+ #endif
+ #if PY_MAJOR_VERSION < 3
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+ #endif
+ 0, /*nb_inplace_add*/
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
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+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
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+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_SNPCallerBase = {
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+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_SNPCallerBase = {
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+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_SNPCallerBase = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_SNPCallerBase = {
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+ sizeof(struct __pyx_obj_9csamtools_SNPCallerBase), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_SNPCallerBase, /*tp_as_number*/
+ &__pyx_tp_as_sequence_SNPCallerBase, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_SNPCallerBase, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_SNPCallerBase, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("Base class for SNP callers.\n\n *min_baseQ*\n minimum base quality (possibly capped by BAQ)\n *capQ_threshold*\n coefficient for adjusting mapQ of poor mappings\n *theta*\n theta in maq consensus calling model\n *n_haplotypes*\n number of haplotypes in the sample\n *het_rate*\n prior of a difference between two haplotypes\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_SNPCallerBase, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_SNPCallerBase, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_9csamtools_SNPCallerBase, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
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+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
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+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_SNPCallerBase, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+static struct __pyx_vtabstruct_9csamtools_IteratorSNPCalls __pyx_vtable_9csamtools_IteratorSNPCalls;
+
+static PyObject *__pyx_tp_new_9csamtools_IteratorSNPCalls(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IteratorSNPCalls *p;
+ PyObject *o = __pyx_tp_new_9csamtools_SNPCallerBase(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IteratorSNPCalls *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_SNPCallerBase*)__pyx_vtabptr_9csamtools_IteratorSNPCalls;
+ if (__pyx_pf_9csamtools_16IteratorSNPCalls___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static PyMethodDef __pyx_methods_9csamtools_IteratorSNPCalls[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_9csamtools_16IteratorSNPCalls___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_9csamtools_16IteratorSNPCalls___next__)},
+ {0, 0, 0, 0}
+};
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
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+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IteratorSNPCalls = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
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+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IteratorSNPCalls = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IteratorSNPCalls = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
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+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
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+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_9csamtools_IteratorSNPCalls = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("csamtools.IteratorSNPCalls"), /*tp_name*/
+ sizeof(struct __pyx_obj_9csamtools_IteratorSNPCalls), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_IteratorSNPCalls, /*tp_as_number*/
+ &__pyx_tp_as_sequence_IteratorSNPCalls, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_IteratorSNPCalls, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_IteratorSNPCalls, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("*(IteratorColumn iterator)*\n\n call SNPs within a region.\n\n *iterator* is a pileup iterator. SNPs will be called\n on all positions returned by this iterator.\n\n This caller is fast if SNPs are called over large continuous\n regions. It is slow, if instantiated frequently and in random\n order as the sequence will have to be reloaded.\n\n "), /*tp_doc*/
+ __pyx_tp_traverse_9csamtools_SNPCallerBase, /*tp_traverse*/
+ __pyx_tp_clear_9csamtools_SNPCallerBase, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_9csamtools_16IteratorSNPCalls___iter__, /*tp_iter*/
+ __pyx_pf_9csamtools_16IteratorSNPCalls___next__, /*tp_iternext*/
+ __pyx_methods_9csamtools_IteratorSNPCalls, /*tp_methods*/
+ 0, /*tp_members*/
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+ 0, /*tp_base*/
+ 0, /*tp_dict*/
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+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IteratorSNPCalls, /*tp_new*/
+ 0, /*tp_free*/
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+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
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+
+static PyObject *__pyx_tp_new_9csamtools_SNPCaller(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_SNPCaller *p;
+ PyObject *o = __pyx_tp_new_9csamtools_SNPCallerBase(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_SNPCaller *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_9csamtools_SNPCallerBase*)__pyx_vtabptr_9csamtools_SNPCaller;
+ if (__pyx_pf_9csamtools_9SNPCaller___cinit__(o, a, k) < 0) {
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+ }
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+}
+
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+ {0, 0, 0, 0}
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+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
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+static PyMappingMethods __pyx_tp_as_mapping_SNPCaller = {
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+static PyBufferProcs __pyx_tp_as_buffer_SNPCaller = {
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+ 0, /*bf_getreadbuffer*/
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+ #endif
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+ 0, /*bf_getsegcount*/
+ #endif
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+ 0, /*bf_getcharbuffer*/
+ #endif
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+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
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+ __pyx_tp_dealloc_9csamtools_SNPCallerBase, /*tp_dealloc*/
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+ 0, /*reserved*/
+ #endif
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+}
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+}
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+}
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+}
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+}
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+}
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+}
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+static PyObject *__pyx_getprop_9csamtools_9IndelCall_mapping_quality(PyObject *o, void *x) {
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+}
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+static PyObject *__pyx_getprop_9csamtools_9IndelCall_coverage(PyObject *o, void *x) {
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+}
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+static PyObject *__pyx_getprop_9csamtools_9IndelCall_first_allele(PyObject *o, void *x) {
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+}
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+static PyObject *__pyx_getprop_9csamtools_9IndelCall_second_allele(PyObject *o, void *x) {
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+}
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+}
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+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_9csamtools_IndexedReads(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_9csamtools_IndexedReads *p;
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_9csamtools_IndexedReads *)o);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ p->index = Py_None; Py_INCREF(Py_None);
+ return o;
+}
+
+static void __pyx_tp_dealloc_9csamtools_IndexedReads(PyObject *o) {
+ struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_9csamtools_12IndexedReads___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ Py_XDECREF(((PyObject *)p->samfile));
+ Py_XDECREF(p->index);
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static int __pyx_tp_traverse_9csamtools_IndexedReads(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
+ if (p->samfile) {
+ e = (*v)(((PyObject*)p->samfile), a); if (e) return e;
+ }
+ if (p->index) {
+ e = (*v)(p->index, a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_9csamtools_IndexedReads(PyObject *o) {
+ struct __pyx_obj_9csamtools_IndexedReads *p = (struct __pyx_obj_9csamtools_IndexedReads *)o;
+ PyObject* tmp;
+ tmp = ((PyObject*)p->samfile);
+ p->samfile = ((struct __pyx_obj_9csamtools_Samfile *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ tmp = ((PyObject*)p->index);
+ p->index = Py_None; Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
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+ {__Pyx_NAMESTR("find"), (PyCFunction)__pyx_pf_9csamtools_12IndexedReads_find, METH_O, __Pyx_DOCSTR(__pyx_doc_9csamtools_12IndexedReads_find)},
+ {0, 0, 0, 0}
+};
+
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
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+ 0, /*nb_invert*/
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+ 0, /*nb_xor*/
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+ #if PY_MAJOR_VERSION < 3
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+ #endif
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+ #endif
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+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
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+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
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+ 0, /*nb_inplace_xor*/
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+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_IndexedReads = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_IndexedReads = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_IndexedReads = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
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+ __pyx_tp_dealloc_9csamtools_IndexedReads, /*tp_dealloc*/
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+ __pyx_tp_clear_9csamtools_IndexedReads, /*tp_clear*/
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+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_9csamtools_IndexedReads, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ __pyx_pf_9csamtools_12IndexedReads___init__, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_9csamtools_IndexedReads, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
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+ {0, 0, 0, 0}
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+
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+ NULL /* m_free */
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+ __pyx_builtin_object = __Pyx_GetName(__pyx_b, __pyx_n_s__object); if (!__pyx_builtin_object) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 117; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_map = __Pyx_GetName(__pyx_b, __pyx_n_s__map); if (!__pyx_builtin_map) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 131; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_ValueError = __Pyx_GetName(__pyx_b, __pyx_n_s__ValueError); if (!__pyx_builtin_ValueError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 271; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_IOError = __Pyx_GetName(__pyx_b, __pyx_n_s__IOError); if (!__pyx_builtin_IOError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 289; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_OverflowError = __Pyx_GetName(__pyx_b, __pyx_n_s__OverflowError); if (!__pyx_builtin_OverflowError) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 666; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ __pyx_builtin_cmp = __Pyx_GetName(__pyx_b, __pyx_n_s__cmp); if (!__pyx_builtin_cmp) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1953; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_builtin_chr = __Pyx_GetName(__pyx_b, __pyx_n_s__chr); if (!__pyx_builtin_chr) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2547; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
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+ return 0;
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+}
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+ __pyx_int_4 = PyInt_FromLong(4); if (unlikely(!__pyx_int_4)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_8 = PyInt_FromLong(8); if (unlikely(!__pyx_int_8)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
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+ __pyx_int_16 = PyInt_FromLong(16); if (unlikely(!__pyx_int_16)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_32 = PyInt_FromLong(32); if (unlikely(!__pyx_int_32)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_40 = PyInt_FromLong(40); if (unlikely(!__pyx_int_40)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_60 = PyInt_FromLong(60); if (unlikely(!__pyx_int_60)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
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+ __pyx_int_536870912 = PyInt_FromLong(536870912); if (unlikely(!__pyx_int_536870912)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_4294967295 = PyInt_FromString((char *)"4294967295", 0, 0); if (unlikely(!__pyx_int_4294967295)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ __pyx_int_neg_2147483648 = PyInt_FromLong(-2147483648); if (unlikely(!__pyx_int_neg_2147483648)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ return 0;
+ __pyx_L1_error:;
+ return -1;
+}
+
+#if PY_MAJOR_VERSION < 3
+PyMODINIT_FUNC initcsamtools(void); /*proto*/
+PyMODINIT_FUNC initcsamtools(void)
+#else
+PyMODINIT_FUNC PyInit_csamtools(void); /*proto*/
+PyMODINIT_FUNC PyInit_csamtools(void)
+#endif
+{
+ PyObject *__pyx_t_1 = NULL;
+ PyObject *__pyx_t_2 = NULL;
+ PyObject *__pyx_t_3 = NULL;
+ PyObject *__pyx_t_4 = NULL;
+ int __pyx_t_5;
+ #if CYTHON_REFNANNY
+ void* __pyx_refnanny = NULL;
+ __Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
+ if (!__Pyx_RefNanny) {
+ PyErr_Clear();
+ __Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
+ if (!__Pyx_RefNanny)
+ Py_FatalError("failed to import 'refnanny' module");
+ }
+ __pyx_refnanny = __Pyx_RefNanny->SetupContext("PyMODINIT_FUNC PyInit_csamtools(void)", __LINE__, __FILE__);
+ #endif
+ __pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ #ifdef __pyx_binding_PyCFunctionType_USED
+ if (__pyx_binding_PyCFunctionType_init() < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ #endif
+ /*--- Library function declarations ---*/
+ /*--- Threads initialization code ---*/
+ #if defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
+ #ifdef WITH_THREAD /* Python build with threading support? */
+ PyEval_InitThreads();
+ #endif
+ #endif
+ /*--- Module creation code ---*/
+ #if PY_MAJOR_VERSION < 3
+ __pyx_m = Py_InitModule4(__Pyx_NAMESTR("csamtools"), __pyx_methods, 0, 0, PYTHON_API_VERSION);
+ #else
+ __pyx_m = PyModule_Create(&__pyx_moduledef);
+ #endif
+ if (!__pyx_m) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ #if PY_MAJOR_VERSION < 3
+ Py_INCREF(__pyx_m);
+ #endif
+ __pyx_b = PyImport_AddModule(__Pyx_NAMESTR(__Pyx_BUILTIN_MODULE_NAME));
+ if (!__pyx_b) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ if (__Pyx_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ /*--- Initialize various global constants etc. ---*/
+ if (unlikely(__Pyx_InitGlobals() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__pyx_module_is_main_csamtools) {
+ if (__Pyx_SetAttrString(__pyx_m, "__name__", __pyx_n_s____main__) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;};
+ }
+ /*--- Builtin init code ---*/
+ if (unlikely(__Pyx_InitCachedBuiltins() < 0)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ /*--- Global init code ---*/
+ /*--- Function export code ---*/
+ /*--- Type init code ---*/
+ __pyx_ptype_9csamtools_file = __Pyx_ImportType(__Pyx_BUILTIN_MODULE_NAME, "file", sizeof(PyFileObject), 0); if (unlikely(!__pyx_ptype_9csamtools_file)) {__pyx_filename = __pyx_f[1]; __pyx_lineno = 60; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (PyType_Ready(&__pyx_type_9csamtools_AlignedRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_AlignedRead, "__str__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_11AlignedRead___str__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_11AlignedRead___str__.doc = __pyx_doc_9csamtools_11AlignedRead___str__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_11AlignedRead___str__;
+ }
+ }
+ if (__Pyx_SetAttrString(__pyx_m, "AlignedRead", (PyObject *)&__pyx_type_9csamtools_AlignedRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1867; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_AlignedRead = &__pyx_type_9csamtools_AlignedRead;
+ __pyx_vtabptr_9csamtools_Samfile = &__pyx_vtable_9csamtools_Samfile;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_Samfile._buildHeader = (bam_header_t *(*)(struct __pyx_obj_9csamtools_Samfile *, PyObject *))__pyx_f_9csamtools_7Samfile__buildHeader;
+ __pyx_vtable_9csamtools_Samfile.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_Samfile *))__pyx_f_9csamtools_7Samfile_getCurrent;
+ __pyx_vtable_9csamtools_Samfile.cnext = (int (*)(struct __pyx_obj_9csamtools_Samfile *))__pyx_f_9csamtools_7Samfile_cnext;
+ __pyx_vtable_9csamtools_Samfile.write = (int (*)(struct __pyx_obj_9csamtools_Samfile *, struct __pyx_obj_9csamtools_AlignedRead *, int __pyx_skip_dispatch))__pyx_f_9csamtools_7Samfile_write;
+ __pyx_vtable_9csamtools_Samfile._getrname = (char *(*)(struct __pyx_obj_9csamtools_Samfile *, int))__pyx_f_9csamtools_7Samfile__getrname;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_Samfile._buildHeader = (void(*)(void))__pyx_f_9csamtools_7Samfile__buildHeader;
+ *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.getCurrent = (void(*)(void))__pyx_f_9csamtools_7Samfile_getCurrent;
+ *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.cnext = (void(*)(void))__pyx_f_9csamtools_7Samfile_cnext;
+ *(void(**)(void))&__pyx_vtable_9csamtools_Samfile.write = (void(*)(void))__pyx_f_9csamtools_7Samfile_write;
+ *(void(**)(void))&__pyx_vtable_9csamtools_Samfile._getrname = (void(*)(void))__pyx_f_9csamtools_7Samfile__getrname;
+ #endif
+ if (PyType_Ready(&__pyx_type_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_Samfile, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_7Samfile___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_7Samfile___next__.doc = __pyx_doc_9csamtools_7Samfile___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_7Samfile___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_Samfile.tp_dict, __pyx_vtabptr_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "Samfile", (PyObject *)&__pyx_type_9csamtools_Samfile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 415; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_Samfile = &__pyx_type_9csamtools_Samfile;
+ if (PyType_Ready(&__pyx_type_9csamtools_PileupProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2601; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "PileupProxy", (PyObject *)&__pyx_type_9csamtools_PileupProxy) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2601; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_PileupProxy = &__pyx_type_9csamtools_PileupProxy;
+ if (PyType_Ready(&__pyx_type_9csamtools_PileupRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2654; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "PileupRead", (PyObject *)&__pyx_type_9csamtools_PileupRead) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2654; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_PileupRead = &__pyx_type_9csamtools_PileupRead;
+ __pyx_vtabptr_9csamtools_Fastafile = &__pyx_vtable_9csamtools_Fastafile;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_Fastafile._fetch = (char *(*)(struct __pyx_obj_9csamtools_Fastafile *, char *, int, int, int *))__pyx_f_9csamtools_9Fastafile__fetch;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_Fastafile._fetch = (void(*)(void))__pyx_f_9csamtools_9Fastafile__fetch;
+ #endif
+ if (PyType_Ready(&__pyx_type_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_Fastafile.tp_dict, __pyx_vtabptr_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "Fastafile", (PyObject *)&__pyx_type_9csamtools_Fastafile) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 244; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_Fastafile = &__pyx_type_9csamtools_Fastafile;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorRow) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1187; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorRow", (PyObject *)&__pyx_type_9csamtools_IteratorRow) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1187; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorRow = &__pyx_type_9csamtools_IteratorRow;
+ __pyx_vtabptr_9csamtools_IteratorRowRegion = &__pyx_vtable_9csamtools_IteratorRowRegion;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_IteratorRowRegion.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowRegion *))__pyx_f_9csamtools_17IteratorRowRegion_getCurrent;
+ __pyx_vtable_9csamtools_IteratorRowRegion.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowRegion *))__pyx_f_9csamtools_17IteratorRowRegion_cnext;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowRegion.getCurrent = (void(*)(void))__pyx_f_9csamtools_17IteratorRowRegion_getCurrent;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowRegion.cnext = (void(*)(void))__pyx_f_9csamtools_17IteratorRowRegion_cnext;
+ #endif
+ __pyx_type_9csamtools_IteratorRowRegion.tp_base = __pyx_ptype_9csamtools_IteratorRow;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowRegion, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__.doc = __pyx_doc_9csamtools_17IteratorRowRegion___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_17IteratorRowRegion___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowRegion.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorRowRegion", (PyObject *)&__pyx_type_9csamtools_IteratorRowRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1206; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorRowRegion = &__pyx_type_9csamtools_IteratorRowRegion;
+ __pyx_vtabptr_9csamtools_IteratorRowAll = &__pyx_vtable_9csamtools_IteratorRowAll;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_IteratorRowAll.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowAll *))__pyx_f_9csamtools_14IteratorRowAll_getCurrent;
+ __pyx_vtable_9csamtools_IteratorRowAll.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowAll *))__pyx_f_9csamtools_14IteratorRowAll_cnext;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowAll.getCurrent = (void(*)(void))__pyx_f_9csamtools_14IteratorRowAll_getCurrent;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowAll.cnext = (void(*)(void))__pyx_f_9csamtools_14IteratorRowAll_cnext;
+ #endif
+ __pyx_type_9csamtools_IteratorRowAll.tp_base = __pyx_ptype_9csamtools_IteratorRow;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowAll, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_14IteratorRowAll___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_14IteratorRowAll___next__.doc = __pyx_doc_9csamtools_14IteratorRowAll___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_14IteratorRowAll___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowAll.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorRowAll", (PyObject *)&__pyx_type_9csamtools_IteratorRowAll) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1292; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorRowAll = &__pyx_type_9csamtools_IteratorRowAll;
+ __pyx_type_9csamtools_IteratorRowAllRefs.tp_base = __pyx_ptype_9csamtools_IteratorRow;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowAllRefs, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__.doc = __pyx_doc_9csamtools_18IteratorRowAllRefs___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_18IteratorRowAllRefs___next__;
+ }
+ }
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorRowAllRefs", (PyObject *)&__pyx_type_9csamtools_IteratorRowAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1356; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorRowAllRefs = &__pyx_type_9csamtools_IteratorRowAllRefs;
+ __pyx_vtabptr_9csamtools_IteratorRowSelection = &__pyx_vtable_9csamtools_IteratorRowSelection;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_IteratorRowSelection.getCurrent = (bam1_t *(*)(struct __pyx_obj_9csamtools_IteratorRowSelection *))__pyx_f_9csamtools_20IteratorRowSelection_getCurrent;
+ __pyx_vtable_9csamtools_IteratorRowSelection.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorRowSelection *))__pyx_f_9csamtools_20IteratorRowSelection_cnext;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowSelection.getCurrent = (void(*)(void))__pyx_f_9csamtools_20IteratorRowSelection_getCurrent;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorRowSelection.cnext = (void(*)(void))__pyx_f_9csamtools_20IteratorRowSelection_cnext;
+ #endif
+ __pyx_type_9csamtools_IteratorRowSelection.tp_base = __pyx_ptype_9csamtools_IteratorRow;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorRowSelection, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__.doc = __pyx_doc_9csamtools_20IteratorRowSelection___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_20IteratorRowSelection___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorRowSelection.tp_dict, __pyx_vtabptr_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorRowSelection", (PyObject *)&__pyx_type_9csamtools_IteratorRowSelection) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1402; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorRowSelection = &__pyx_type_9csamtools_IteratorRowSelection;
+ __pyx_vtabptr_9csamtools_IteratorColumn = &__pyx_vtable_9csamtools_IteratorColumn;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_IteratorColumn.cnext = (int (*)(struct __pyx_obj_9csamtools_IteratorColumn *))__pyx_f_9csamtools_14IteratorColumn_cnext;
+ __pyx_vtable_9csamtools_IteratorColumn.getSequence = (char *(*)(struct __pyx_obj_9csamtools_IteratorColumn *))__pyx_f_9csamtools_14IteratorColumn_getSequence;
+ __pyx_vtable_9csamtools_IteratorColumn.setMask = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *))__pyx_f_9csamtools_14IteratorColumn_setMask;
+ __pyx_vtable_9csamtools_IteratorColumn.setupIteratorData = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, int, int, int, struct __pyx_opt_args_9csamtools_14IteratorColumn_setupIteratorData *__pyx_optional_args))__pyx_f_9csamtools_14IteratorColumn_setupIteratorData;
+ __pyx_vtable_9csamtools_IteratorColumn.reset = (PyObject *(*)(struct __pyx_obj_9csamtools_IteratorColumn *, PyObject *, PyObject *, PyObject *))__pyx_f_9csamtools_14IteratorColumn_reset;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.cnext = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_cnext;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.getSequence = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_getSequence;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.setMask = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_setMask;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.setupIteratorData = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_setupIteratorData;
+ *(void(**)(void))&__pyx_vtable_9csamtools_IteratorColumn.reset = (void(*)(void))__pyx_f_9csamtools_14IteratorColumn_reset;
+ #endif
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumn.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorColumn", (PyObject *)&__pyx_type_9csamtools_IteratorColumn) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1542; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorColumn = &__pyx_type_9csamtools_IteratorColumn;
+ __pyx_vtabptr_9csamtools_IteratorColumnRegion = &__pyx_vtable_9csamtools_IteratorColumnRegion;
+ __pyx_vtable_9csamtools_IteratorColumnRegion.__pyx_base = *__pyx_vtabptr_9csamtools_IteratorColumn;
+ __pyx_type_9csamtools_IteratorColumnRegion.tp_base = __pyx_ptype_9csamtools_IteratorColumn;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorColumnRegion, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__.doc = __pyx_doc_9csamtools_20IteratorColumnRegion___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_20IteratorColumnRegion___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumnRegion.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorColumnRegion", (PyObject *)&__pyx_type_9csamtools_IteratorColumnRegion) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1712; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorColumnRegion = &__pyx_type_9csamtools_IteratorColumnRegion;
+ __pyx_vtabptr_9csamtools_IteratorColumnAllRefs = &__pyx_vtable_9csamtools_IteratorColumnAllRefs;
+ __pyx_vtable_9csamtools_IteratorColumnAllRefs.__pyx_base = *__pyx_vtabptr_9csamtools_IteratorColumn;
+ __pyx_type_9csamtools_IteratorColumnAllRefs.tp_base = __pyx_ptype_9csamtools_IteratorColumn;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorColumnAllRefs, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__.doc = __pyx_doc_9csamtools_21IteratorColumnAllRefs___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_21IteratorColumnAllRefs___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorColumnAllRefs.tp_dict, __pyx_vtabptr_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorColumnAllRefs", (PyObject *)&__pyx_type_9csamtools_IteratorColumnAllRefs) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1741; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorColumnAllRefs = &__pyx_type_9csamtools_IteratorColumnAllRefs;
+ if (PyType_Ready(&__pyx_type_9csamtools_SNPCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2816; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "SNPCall", (PyObject *)&__pyx_type_9csamtools_SNPCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2816; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_SNPCall = &__pyx_type_9csamtools_SNPCall;
+ __pyx_vtabptr_9csamtools_SNPCallerBase = &__pyx_vtable_9csamtools_SNPCallerBase;
+ #if PY_MAJOR_VERSION >= 3
+ __pyx_vtable_9csamtools_SNPCallerBase.__dump = (PyObject *(*)(struct __pyx_obj_9csamtools_SNPCallerBase *, glf1_t *, uint32_t, int))__pyx_f_9csamtools_13SNPCallerBase___dump;
+ #else
+ *(void(**)(void))&__pyx_vtable_9csamtools_SNPCallerBase.__dump = (void(*)(void))__pyx_f_9csamtools_13SNPCallerBase___dump;
+ #endif
+ if (PyType_Ready(&__pyx_type_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_SNPCallerBase.tp_dict, __pyx_vtabptr_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "SNPCallerBase", (PyObject *)&__pyx_type_9csamtools_SNPCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2873; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_SNPCallerBase = &__pyx_type_9csamtools_SNPCallerBase;
+ __pyx_vtabptr_9csamtools_IteratorSNPCalls = &__pyx_vtable_9csamtools_IteratorSNPCalls;
+ __pyx_vtable_9csamtools_IteratorSNPCalls.__pyx_base = *__pyx_vtabptr_9csamtools_SNPCallerBase;
+ __pyx_type_9csamtools_IteratorSNPCalls.tp_base = __pyx_ptype_9csamtools_SNPCallerBase;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorSNPCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorSNPCalls, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_16IteratorSNPCalls___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_16IteratorSNPCalls___next__.doc = __pyx_doc_9csamtools_16IteratorSNPCalls___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_16IteratorSNPCalls___next__;
+ }
+ }
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_IteratorSNPCalls.tp_dict, __pyx_vtabptr_9csamtools_IteratorSNPCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorSNPCalls", (PyObject *)&__pyx_type_9csamtools_IteratorSNPCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 2946; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorSNPCalls = &__pyx_type_9csamtools_IteratorSNPCalls;
+ __pyx_vtabptr_9csamtools_SNPCaller = &__pyx_vtable_9csamtools_SNPCaller;
+ __pyx_vtable_9csamtools_SNPCaller.__pyx_base = *__pyx_vtabptr_9csamtools_SNPCallerBase;
+ __pyx_type_9csamtools_SNPCaller.tp_base = __pyx_ptype_9csamtools_SNPCallerBase;
+ if (PyType_Ready(&__pyx_type_9csamtools_SNPCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3021; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetVtable(__pyx_type_9csamtools_SNPCaller.tp_dict, __pyx_vtabptr_9csamtools_SNPCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3021; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "SNPCaller", (PyObject *)&__pyx_type_9csamtools_SNPCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3021; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_SNPCaller = &__pyx_type_9csamtools_SNPCaller;
+ if (PyType_Ready(&__pyx_type_9csamtools_IndelCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3103; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IndelCall", (PyObject *)&__pyx_type_9csamtools_IndelCall) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3103; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IndelCall = &__pyx_type_9csamtools_IndelCall;
+ if (PyType_Ready(&__pyx_type_9csamtools_IndelCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3192; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IndelCallerBase", (PyObject *)&__pyx_type_9csamtools_IndelCallerBase) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3192; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IndelCallerBase = &__pyx_type_9csamtools_IndelCallerBase;
+ __pyx_type_9csamtools_IndelCaller.tp_base = __pyx_ptype_9csamtools_IndelCallerBase;
+ if (PyType_Ready(&__pyx_type_9csamtools_IndelCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3287; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IndelCaller", (PyObject *)&__pyx_type_9csamtools_IndelCaller) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3287; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IndelCaller = &__pyx_type_9csamtools_IndelCaller;
+ __pyx_type_9csamtools_IteratorIndelCalls.tp_base = __pyx_ptype_9csamtools_IndelCallerBase;
+ if (PyType_Ready(&__pyx_type_9csamtools_IteratorIndelCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3330; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ {
+ PyObject *wrapper = __Pyx_GetAttrString((PyObject *)&__pyx_type_9csamtools_IteratorIndelCalls, "__next__"); if (unlikely(!wrapper)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3330; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
+ __pyx_wrapperbase_9csamtools_18IteratorIndelCalls___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
+ __pyx_wrapperbase_9csamtools_18IteratorIndelCalls___next__.doc = __pyx_doc_9csamtools_18IteratorIndelCalls___next__;
+ ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_9csamtools_18IteratorIndelCalls___next__;
+ }
+ }
+ if (__Pyx_SetAttrString(__pyx_m, "IteratorIndelCalls", (PyObject *)&__pyx_type_9csamtools_IteratorIndelCalls) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3330; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IteratorIndelCalls = &__pyx_type_9csamtools_IteratorIndelCalls;
+ if (PyType_Ready(&__pyx_type_9csamtools_IndexedReads) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3370; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ if (__Pyx_SetAttrString(__pyx_m, "IndexedReads", (PyObject *)&__pyx_type_9csamtools_IndexedReads) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 3370; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __pyx_ptype_9csamtools_IndexedReads = &__pyx_type_9csamtools_IndexedReads;
+ /*--- Type import code ---*/
+ __pyx_ptype_7cpython_4bool_bool = __Pyx_ImportType(__Pyx_BUILTIN_MODULE_NAME, "bool", sizeof(PyBoolObject), 0); if (unlikely(!__pyx_ptype_7cpython_4bool_bool)) {__pyx_filename = __pyx_f[2]; __pyx_lineno = 8; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ /*--- Function import code ---*/
+ /*--- Execution code ---*/
+
+ /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":4
+ * # cython: profile=True
+ * # adds doc-strings for sphinx
+ * import tempfile # <<<<<<<<<<<<<<
+ * import os
+ * import sys
+ */
+ __pyx_t_1 = __Pyx_Import(((PyObject *)__pyx_n_s__tempfile), 0); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 4; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_GOTREF(__pyx_t_1);
+ if (PyObject_SetAttr(__pyx_m, __pyx_n_s__tempfile, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 4; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
+
+ /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":5
+ * # adds doc-strings for sphinx
+ * import tempfile
+ * import os # <<<<<<<<<<<<<<
+ * import sys
+ * import types
+ */
+ __pyx_t_1 = __Pyx_Import(((PyObject *)__pyx_n_s__os), 0); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 5; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_GOTREF(__pyx_t_1);
+ if (PyObject_SetAttr(__pyx_m, __pyx_n_s__os, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 5; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":6
+ * import tempfile
+ * import os
+ * import sys # <<<<<<<<<<<<<<
+ * import types
+ * import itertools
+ */
+ __pyx_t_1 = __Pyx_Import(((PyObject *)__pyx_n_s__sys), 0); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 6; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_GOTREF(__pyx_t_1);
+ if (PyObject_SetAttr(__pyx_m, __pyx_n_s__sys, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 6; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":7
+ * import os
+ * import sys
+ * import types # <<<<<<<<<<<<<<
+ * import itertools
+ * import struct
+ */
+ __pyx_t_1 = __Pyx_Import(((PyObject *)__pyx_n_s__types), 0); if (unlikely(!__pyx_t_1)) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 7; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_GOTREF(__pyx_t_1);
+ if (PyObject_SetAttr(__pyx_m, __pyx_n_s__types, __pyx_t_1) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 7; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
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+ /* "/ifs/devel/pysam/pysam/pysam/csamtools.pyx":8
+ * import sys
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+ more_or_less = "exactly";
+ }
+ number = (num_expected == 1) ? "" : "s";
+ PyErr_Format(PyExc_TypeError,
+ #if PY_VERSION_HEX < 0x02050000
+ "%s() takes %s %d positional argument%s (%d given)",
+ #else
+ "%s() takes %s %zd positional argument%s (%zd given)",
+ #endif
+ func_name, more_or_less, num_expected, number, num_found);
+}
+
+static int __Pyx_ParseOptionalKeywords(
+ PyObject *kwds,
+ PyObject **argnames[],
+ PyObject *kwds2,
+ PyObject *values[],
+ Py_ssize_t num_pos_args,
+ const char* function_name)
+{
+ PyObject *key = 0, *value = 0;
+ Py_ssize_t pos = 0;
+ PyObject*** name;
+ PyObject*** first_kw_arg = argnames + num_pos_args;
+
+ while (PyDict_Next(kwds, &pos, &key, &value)) {
+ name = first_kw_arg;
+ while (*name && (**name != key)) name++;
+ if (*name) {
+ values[name-argnames] = value;
+ } else {
+ #if PY_MAJOR_VERSION < 3
+ if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key))) {
+ #else
+ if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key))) {
+ #endif
+ goto invalid_keyword_type;
+ } else {
+ for (name = first_kw_arg; *name; name++) {
+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) break;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+ _PyString_Eq(**name, key)) break;
+ #endif
+ }
+ if (*name) {
+ values[name-argnames] = value;
+ } else {
+ /* unexpected keyword found */
+ for (name=argnames; name != first_kw_arg; name++) {
+ if (**name == key) goto arg_passed_twice;
+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+ _PyString_Eq(**name, key)) goto arg_passed_twice;
+ #endif
+ }
+ if (kwds2) {
+ if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
+ } else {
+ goto invalid_keyword;
+ }
+ }
+ }
+ }
+ }
+ return 0;
+arg_passed_twice:
+ __Pyx_RaiseDoubleKeywordsError(function_name, **name);
+ goto bad;
+invalid_keyword_type:
+ PyErr_Format(PyExc_TypeError,
+ "%s() keywords must be strings", function_name);
+ goto bad;
+invalid_keyword:
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION < 3
+ "%s() got an unexpected keyword argument '%s'",
+ function_name, PyString_AsString(key));
+ #else
+ "%s() got an unexpected keyword argument '%U'",
+ function_name, key);
+ #endif
+bad:
+ return -1;
+}
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+
+ tmp_type = tstate->curexc_type;
+ tmp_value = tstate->curexc_value;
+ tmp_tb = tstate->curexc_traceback;
+ tstate->curexc_type = type;
+ tstate->curexc_value = value;
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->curexc_type;
+ *value = tstate->curexc_value;
+ *tb = tstate->curexc_traceback;
+
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+}
+
+
+static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
+ const char *name, int exact)
+{
+ if (!type) {
+ PyErr_Format(PyExc_SystemError, "Missing type object");
+ return 0;
+ }
+ if (none_allowed && obj == Py_None) return 1;
+ else if (exact) {
+ if (Py_TYPE(obj) == type) return 1;
+ }
+ else {
+ if (PyObject_TypeCheck(obj, type)) return 1;
+ }
+ PyErr_Format(PyExc_TypeError,
+ "Argument '%s' has incorrect type (expected %s, got %s)",
+ name, type->tp_name, Py_TYPE(obj)->tp_name);
+ return 0;
+}
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb) {
+ PyObject *local_type, *local_value, *local_tb;
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ local_type = tstate->curexc_type;
+ local_value = tstate->curexc_value;
+ local_tb = tstate->curexc_traceback;
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+ PyErr_NormalizeException(&local_type, &local_value, &local_tb);
+ if (unlikely(tstate->curexc_type))
+ goto bad;
+ #if PY_MAJOR_VERSION >= 3
+ if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
+ goto bad;
+ #endif
+ *type = local_type;
+ *value = local_value;
+ *tb = local_tb;
+ Py_INCREF(local_type);
+ Py_INCREF(local_value);
+ Py_INCREF(local_tb);
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = local_type;
+ tstate->exc_value = local_value;
+ tstate->exc_traceback = local_tb;
+ /* Make sure tstate is in a consistent state when we XDECREF
+ these objects (XDECREF may run arbitrary code). */
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+ return 0;
+bad:
+ *type = 0;
+ *value = 0;
+ *tb = 0;
+ Py_XDECREF(local_type);
+ Py_XDECREF(local_value);
+ Py_XDECREF(local_tb);
+ return -1;
+}
+
+
+
+static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void) {
+ PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
+ PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
+}
+
+static CYTHON_INLINE long __Pyx_div_long(long a, long b) {
+ long q = a / b;
+ long r = a - q*b;
+ q -= ((r != 0) & ((r ^ b) < 0));
+ return q;
+}
+
+static CYTHON_INLINE long __Pyx_mod_long(long a, long b) {
+ long r = a % b;
+ r += ((r != 0) & ((r ^ b) < 0)) * b;
+ return r;
+}
+
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->exc_type;
+ *value = tstate->exc_value;
+ *tb = tstate->exc_traceback;
+ Py_XINCREF(*type);
+ Py_XINCREF(*value);
+ Py_XINCREF(*tb);
+}
+
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = type;
+ tstate->exc_value = value;
+ tstate->exc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
+ PyObject *py_import = 0;
+ PyObject *empty_list = 0;
+ PyObject *module = 0;
+ PyObject *global_dict = 0;
+ PyObject *empty_dict = 0;
+ PyObject *list;
+ py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
+ if (!py_import)
+ goto bad;
+ if (from_list)
+ list = from_list;
+ else {
+ empty_list = PyList_New(0);
+ if (!empty_list)
+ goto bad;
+ list = empty_list;
+ }
+ global_dict = PyModule_GetDict(__pyx_m);
+ if (!global_dict)
+ goto bad;
+ empty_dict = PyDict_New();
+ if (!empty_dict)
+ goto bad;
+ module = PyObject_CallFunctionObjArgs(py_import,
+ name, global_dict, empty_dict, list, NULL);
+bad:
+ Py_XDECREF(empty_list);
+ Py_XDECREF(py_import);
+ Py_XDECREF(empty_dict);
+ return module;
+}
+
+static PyObject *__Pyx_CreateClass(
+ PyObject *bases, PyObject *dict, PyObject *name, const char *modname)
+{
+ PyObject *py_modname;
+ PyObject *result = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_modname = PyString_FromString(modname);
+ #else
+ py_modname = PyUnicode_FromString(modname);
+ #endif
+ if (!py_modname)
+ goto bad;
+ if (PyDict_SetItemString(dict, "__module__", py_modname) < 0)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ result = PyClass_New(bases, dict, name);
+ #else
+ result = PyObject_CallFunctionObjArgs((PyObject *)&PyType_Type, name, bases, dict, NULL);
+ #endif
+bad:
+ Py_XDECREF(py_modname);
+ return result;
+}
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t val) {
+ const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(uint32_t) == sizeof(char)) ||
+ (sizeof(uint32_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(uint32_t) == sizeof(int)) ||
+ (sizeof(uint32_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(uint32_t),
+ little, !is_unsigned);
+ }
+}
+
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ Py_XINCREF(type);
+ Py_XINCREF(value);
+ Py_XINCREF(tb);
+ /* First, check the traceback argument, replacing None with NULL. */
+ if (tb == Py_None) {
+ Py_DECREF(tb);
+ tb = 0;
+ }
+ else if (tb != NULL && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto raise_error;
+ }
+ /* Next, replace a missing value with None */
+ if (value == NULL) {
+ value = Py_None;
+ Py_INCREF(value);
+ }
+ #if PY_VERSION_HEX < 0x02050000
+ if (!PyClass_Check(type))
+ #else
+ if (!PyType_Check(type))
+ #endif
+ {
+ /* Raising an instance. The value should be a dummy. */
+ if (value != Py_None) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto raise_error;
+ }
+ /* Normalize to raise <class>, <instance> */
+ Py_DECREF(value);
+ value = type;
+ #if PY_VERSION_HEX < 0x02050000
+ if (PyInstance_Check(type)) {
+ type = (PyObject*) ((PyInstanceObject*)type)->in_class;
+ Py_INCREF(type);
+ }
+ else {
+ type = 0;
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception must be an old-style class or instance");
+ goto raise_error;
+ }
+ #else
+ type = (PyObject*) Py_TYPE(type);
+ Py_INCREF(type);
+ if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto raise_error;
+ }
+ #endif
+ }
+
+ __Pyx_ErrRestore(type, value, tb);
+ return;
+raise_error:
+ Py_XDECREF(value);
+ Py_XDECREF(type);
+ Py_XDECREF(tb);
+ return;
+}
+
+#else /* Python 3+ */
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ if (tb == Py_None) {
+ tb = 0;
+ } else if (tb && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto bad;
+ }
+ if (value == Py_None)
+ value = 0;
+
+ if (PyExceptionInstance_Check(type)) {
+ if (value) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto bad;
+ }
+ value = type;
+ type = (PyObject*) Py_TYPE(value);
+ } else if (!PyExceptionClass_Check(type)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto bad;
+ }
+
+ PyErr_SetObject(type, value);
+
+ if (tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ PyObject* tmp_tb = tstate->curexc_traceback;
+ if (tb != tmp_tb) {
+ Py_INCREF(tb);
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_tb);
+ }
+ }
+
+bad:
+ return;
+}
+#endif
+
+static CYTHON_INLINE uint32_t __Pyx_PyInt_from_py_uint32_t(PyObject* x) {
+ const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if (sizeof(uint32_t) == sizeof(char)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedChar(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedChar(x);
+ } else if (sizeof(uint32_t) == sizeof(short)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedShort(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedShort(x);
+ } else if (sizeof(uint32_t) == sizeof(int)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedInt(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedInt(x);
+ } else if (sizeof(uint32_t) == sizeof(long)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedLong(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedLong(x);
+ } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return (uint32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
+ else
+ return (uint32_t)__Pyx_PyInt_AsSignedLongLong(x);
+ } else {
+ uint32_t val;
+ PyObject *v = __Pyx_PyNumber_Int(x);
+ #if PY_VERSION_HEX < 0x03000000
+ if (likely(v) && !PyLong_Check(v)) {
+ PyObject *tmp = v;
+ v = PyNumber_Long(tmp);
+ Py_DECREF(tmp);
+ }
+ #endif
+ if (likely(v)) {
+ int one = 1; int is_little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ int ret = _PyLong_AsByteArray((PyLongObject *)v,
+ bytes, sizeof(val),
+ is_little, !is_unsigned);
+ Py_DECREF(v);
+ if (likely(!ret))
+ return val;
+ }
+ return (uint32_t)-1;
+ }
+}
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int32_t(int32_t val) {
+ const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(int32_t) == sizeof(char)) ||
+ (sizeof(int32_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(int32_t) == sizeof(int)) ||
+ (sizeof(int32_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(int32_t),
+ little, !is_unsigned);
+ }
+}
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_int64_t(int64_t val) {
+ const int64_t neg_one = (int64_t)-1, const_zero = (int64_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(int64_t) == sizeof(char)) ||
+ (sizeof(int64_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(int64_t) == sizeof(int)) ||
+ (sizeof(int64_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(int64_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(int64_t),
+ little, !is_unsigned);
+ }
+}
+
+static CYTHON_INLINE uint64_t __Pyx_PyInt_from_py_uint64_t(PyObject* x) {
+ const uint64_t neg_one = (uint64_t)-1, const_zero = (uint64_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if (sizeof(uint64_t) == sizeof(char)) {
+ if (is_unsigned)
+ return (uint64_t)__Pyx_PyInt_AsUnsignedChar(x);
+ else
+ return (uint64_t)__Pyx_PyInt_AsSignedChar(x);
+ } else if (sizeof(uint64_t) == sizeof(short)) {
+ if (is_unsigned)
+ return (uint64_t)__Pyx_PyInt_AsUnsignedShort(x);
+ else
+ return (uint64_t)__Pyx_PyInt_AsSignedShort(x);
+ } else if (sizeof(uint64_t) == sizeof(int)) {
+ if (is_unsigned)
+ return (uint64_t)__Pyx_PyInt_AsUnsignedInt(x);
+ else
+ return (uint64_t)__Pyx_PyInt_AsSignedInt(x);
+ } else if (sizeof(uint64_t) == sizeof(long)) {
+ if (is_unsigned)
+ return (uint64_t)__Pyx_PyInt_AsUnsignedLong(x);
+ else
+ return (uint64_t)__Pyx_PyInt_AsSignedLong(x);
+ } else if (sizeof(uint64_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return (uint64_t)__Pyx_PyInt_AsUnsignedLongLong(x);
+ else
+ return (uint64_t)__Pyx_PyInt_AsSignedLongLong(x);
+ } else {
+ uint64_t val;
+ PyObject *v = __Pyx_PyNumber_Int(x);
+ #if PY_VERSION_HEX < 0x03000000
+ if (likely(v) && !PyLong_Check(v)) {
+ PyObject *tmp = v;
+ v = PyNumber_Long(tmp);
+ Py_DECREF(tmp);
+ }
+ #endif
+ if (likely(v)) {
+ int one = 1; int is_little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ int ret = _PyLong_AsByteArray((PyLongObject *)v,
+ bytes, sizeof(val),
+ is_little, !is_unsigned);
+ Py_DECREF(v);
+ if (likely(!ret))
+ return val;
+ }
+ return (uint64_t)-1;
+ }
+}
+
+static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject* x) {
+ const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if (sizeof(int32_t) == sizeof(char)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedChar(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedChar(x);
+ } else if (sizeof(int32_t) == sizeof(short)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedShort(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedShort(x);
+ } else if (sizeof(int32_t) == sizeof(int)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedInt(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedInt(x);
+ } else if (sizeof(int32_t) == sizeof(long)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedLong(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedLong(x);
+ } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedLongLong(x);
+ } else {
+ int32_t val;
+ PyObject *v = __Pyx_PyNumber_Int(x);
+ #if PY_VERSION_HEX < 0x03000000
+ if (likely(v) && !PyLong_Check(v)) {
+ PyObject *tmp = v;
+ v = PyNumber_Long(tmp);
+ Py_DECREF(tmp);
+ }
+ #endif
+ if (likely(v)) {
+ int one = 1; int is_little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ int ret = _PyLong_AsByteArray((PyLongObject *)v,
+ bytes, sizeof(val),
+ is_little, !is_unsigned);
+ Py_DECREF(v);
+ if (likely(!ret))
+ return val;
+ }
+ return (int32_t)-1;
+ }
+}
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint8_t(uint8_t val) {
+ const uint8_t neg_one = (uint8_t)-1, const_zero = (uint8_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(uint8_t) == sizeof(char)) ||
+ (sizeof(uint8_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(uint8_t) == sizeof(int)) ||
+ (sizeof(uint8_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(uint8_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(uint8_t),
+ little, !is_unsigned);
+ }
+}
+
+#if PY_MAJOR_VERSION < 3
+static PyObject *__Pyx_GetStdout(void) {
+ PyObject *f = PySys_GetObject((char *)"stdout");
+ if (!f) {
+ PyErr_SetString(PyExc_RuntimeError, "lost sys.stdout");
+ }
+ return f;
+}
+
+static int __Pyx_Print(PyObject* f, PyObject *arg_tuple, int newline) {
+ PyObject* v;
+ int i;
+
+ if (!f) {
+ if (!(f = __Pyx_GetStdout()))
+ return -1;
+ }
+ for (i=0; i < PyTuple_GET_SIZE(arg_tuple); i++) {
+ if (PyFile_SoftSpace(f, 1)) {
+ if (PyFile_WriteString(" ", f) < 0)
+ return -1;
+ }
+ v = PyTuple_GET_ITEM(arg_tuple, i);
+ if (PyFile_WriteObject(v, f, Py_PRINT_RAW) < 0)
+ return -1;
+ if (PyString_Check(v)) {
+ char *s = PyString_AsString(v);
+ Py_ssize_t len = PyString_Size(v);
+ if (len > 0 &&
+ isspace(Py_CHARMASK(s[len-1])) &&
+ s[len-1] != ' ')
+ PyFile_SoftSpace(f, 0);
+ }
+ }
+ if (newline) {
+ if (PyFile_WriteString("\n", f) < 0)
+ return -1;
+ PyFile_SoftSpace(f, 0);
+ }
+ return 0;
+}
+
+#else /* Python 3 has a print function */
+
+static int __Pyx_Print(PyObject* stream, PyObject *arg_tuple, int newline) {
+ PyObject* kwargs = 0;
+ PyObject* result = 0;
+ PyObject* end_string;
+ if (unlikely(!__pyx_print)) {
+ __pyx_print = __Pyx_GetAttrString(__pyx_b, "print");
+ if (!__pyx_print)
+ return -1;
+ }
+ if (stream) {
+ kwargs = PyDict_New();
+ if (unlikely(!kwargs))
+ return -1;
+ if (unlikely(PyDict_SetItemString(kwargs, "file", stream) < 0))
+ goto bad;
+ if (!newline) {
+ end_string = PyUnicode_FromStringAndSize(" ", 1);
+ if (unlikely(!end_string))
+ goto bad;
+ if (PyDict_SetItemString(kwargs, "end", end_string) < 0) {
+ Py_DECREF(end_string);
+ goto bad;
+ }
+ Py_DECREF(end_string);
+ }
+ } else if (!newline) {
+ if (unlikely(!__pyx_print_kwargs)) {
+ __pyx_print_kwargs = PyDict_New();
+ if (unlikely(!__pyx_print_kwargs))
+ return -1;
+ end_string = PyUnicode_FromStringAndSize(" ", 1);
+ if (unlikely(!end_string))
+ return -1;
+ if (PyDict_SetItemString(__pyx_print_kwargs, "end", end_string) < 0) {
+ Py_DECREF(end_string);
+ return -1;
+ }
+ Py_DECREF(end_string);
+ }
+ kwargs = __pyx_print_kwargs;
+ }
+ result = PyObject_Call(__pyx_print, arg_tuple, kwargs);
+ if (unlikely(kwargs) && (kwargs != __pyx_print_kwargs))
+ Py_DECREF(kwargs);
+ if (!result)
+ return -1;
+ Py_DECREF(result);
+ return 0;
+bad:
+ if (kwargs != __pyx_print_kwargs)
+ Py_XDECREF(kwargs);
+ return -1;
+}
+
+#endif
+
+#if PY_MAJOR_VERSION < 3
+
+static int __Pyx_PrintOne(PyObject* f, PyObject *o) {
+ if (!f) {
+ if (!(f = __Pyx_GetStdout()))
+ return -1;
+ }
+ if (PyFile_SoftSpace(f, 0)) {
+ if (PyFile_WriteString(" ", f) < 0)
+ return -1;
+ }
+ if (PyFile_WriteObject(o, f, Py_PRINT_RAW) < 0)
+ return -1;
+ if (PyFile_WriteString("\n", f) < 0)
+ return -1;
+ return 0;
+ /* the line below is just to avoid compiler
+ * compiler warnings about unused functions */
+ return __Pyx_Print(f, NULL, 0);
+}
+
+#else /* Python 3 has a print function */
+
+static int __Pyx_PrintOne(PyObject* stream, PyObject *o) {
+ int res;
+ PyObject* arg_tuple = PyTuple_New(1);
+ if (unlikely(!arg_tuple))
+ return -1;
+ Py_INCREF(o);
+ PyTuple_SET_ITEM(arg_tuple, 0, o);
+ res = __Pyx_Print(stream, arg_tuple, 1);
+ Py_DECREF(arg_tuple);
+ return res;
+}
+
+#endif
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint64_t(uint64_t val) {
+ const uint64_t neg_one = (uint64_t)-1, const_zero = (uint64_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(uint64_t) == sizeof(char)) ||
+ (sizeof(uint64_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(uint64_t) == sizeof(int)) ||
+ (sizeof(uint64_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(uint64_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(uint64_t),
+ little, !is_unsigned);
+ }
+}
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
+ const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned char" :
+ "value too large to convert to unsigned char");
+ }
+ return (unsigned char)-1;
+ }
+ return (unsigned char)val;
+ }
+ return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
+ const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned short" :
+ "value too large to convert to unsigned short");
+ }
+ return (unsigned short)-1;
+ }
+ return (unsigned short)val;
+ }
+ return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
+ const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned int" :
+ "value too large to convert to unsigned int");
+ }
+ return (unsigned int)-1;
+ }
+ return (unsigned int)val;
+ }
+ return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
+ const char neg_one = (char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to char" :
+ "value too large to convert to char");
+ }
+ return (char)-1;
+ }
+ return (char)val;
+ }
+ return (char)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
+ const short neg_one = (short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to short" :
+ "value too large to convert to short");
+ }
+ return (short)-1;
+ }
+ return (short)val;
+ }
+ return (short)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
+ const signed char neg_one = (signed char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed char" :
+ "value too large to convert to signed char");
+ }
+ return (signed char)-1;
+ }
+ return (signed char)val;
+ }
+ return (signed char)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
+ const signed short neg_one = (signed short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed short" :
+ "value too large to convert to signed short");
+ }
+ return (signed short)-1;
+ }
+ return (signed short)val;
+ }
+ return (signed short)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
+ const signed int neg_one = (signed int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed int" :
+ "value too large to convert to signed int");
+ }
+ return (signed int)-1;
+ }
+ return (signed int)val;
+ }
+ return (signed int)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
+ const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return (unsigned long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ unsigned long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned long)-1;
+ val = __Pyx_PyInt_AsUnsignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
+ const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return (unsigned PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ unsigned PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
+ const long neg_one = (long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return (long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (long)-1;
+ val = __Pyx_PyInt_AsLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
+ const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return (PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
+ const signed long neg_one = (signed long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return (signed long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ signed long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed long)-1;
+ val = __Pyx_PyInt_AsSignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
+ const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return (signed PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ signed PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsSignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static void __Pyx_WriteUnraisable(const char *name) {
+ PyObject *old_exc, *old_val, *old_tb;
+ PyObject *ctx;
+ __Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
+ #if PY_MAJOR_VERSION < 3
+ ctx = PyString_FromString(name);
+ #else
+ ctx = PyUnicode_FromString(name);
+ #endif
+ __Pyx_ErrRestore(old_exc, old_val, old_tb);
+ if (!ctx) {
+ PyErr_WriteUnraisable(Py_None);
+ } else {
+ PyErr_WriteUnraisable(ctx);
+ Py_DECREF(ctx);
+ }
+}
+
+#ifndef __PYX_HAVE_RT_ImportType
+#define __PYX_HAVE_RT_ImportType
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
+ long size, int strict)
+{
+ PyObject *py_module = 0;
+ PyObject *result = 0;
+ PyObject *py_name = 0;
+ char warning[200];
+
+ py_module = __Pyx_ImportModule(module_name);
+ if (!py_module)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(class_name);
+ #else
+ py_name = PyUnicode_FromString(class_name);
+ #endif
+ if (!py_name)
+ goto bad;
+ result = PyObject_GetAttr(py_module, py_name);
+ Py_DECREF(py_name);
+ py_name = 0;
+ Py_DECREF(py_module);
+ py_module = 0;
+ if (!result)
+ goto bad;
+ if (!PyType_Check(result)) {
+ PyErr_Format(PyExc_TypeError,
+ "%s.%s is not a type object",
+ module_name, class_name);
+ goto bad;
+ }
+ if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
+ PyOS_snprintf(warning, sizeof(warning),
+ "%s.%s size changed, may indicate binary incompatibility",
+ module_name, class_name);
+ #if PY_VERSION_HEX < 0x02050000
+ PyErr_Warn(NULL, warning);
+ #else
+ PyErr_WarnEx(NULL, warning, 0);
+ #endif
+ }
+ else if (((PyTypeObject *)result)->tp_basicsize != size) {
+ PyErr_Format(PyExc_ValueError,
+ "%s.%s has the wrong size, try recompiling",
+ module_name, class_name);
+ goto bad;
+ }
+ return (PyTypeObject *)result;
+bad:
+ Py_XDECREF(py_module);
+ Py_XDECREF(result);
+ return 0;
+}
+#endif
+
+#ifndef __PYX_HAVE_RT_ImportModule
+#define __PYX_HAVE_RT_ImportModule
+static PyObject *__Pyx_ImportModule(const char *name) {
+ PyObject *py_name = 0;
+ PyObject *py_module = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(name);
+ #else
+ py_name = PyUnicode_FromString(name);
+ #endif
+ if (!py_name)
+ goto bad;
+ py_module = PyImport_Import(py_name);
+ Py_DECREF(py_name);
+ return py_module;
+bad:
+ Py_XDECREF(py_name);
+ return 0;
+}
+#endif
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+ PyObject *ob = PyCapsule_New(vtable, 0, 0);
+#else
+ PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
+#endif
+ if (!ob)
+ goto bad;
+ if (PyDict_SetItemString(dict, "__pyx_vtable__", ob) < 0)
+ goto bad;
+ Py_DECREF(ob);
+ return 0;
+bad:
+ Py_XDECREF(ob);
+ return -1;
+}
+
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+
+static void __Pyx_AddTraceback(const char *funcname) {
+ PyObject *py_srcfile = 0;
+ PyObject *py_funcname = 0;
+ PyObject *py_globals = 0;
+ PyCodeObject *py_code = 0;
+ PyFrameObject *py_frame = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_srcfile = PyString_FromString(__pyx_filename);
+ #else
+ py_srcfile = PyUnicode_FromString(__pyx_filename);
+ #endif
+ if (!py_srcfile) goto bad;
+ if (__pyx_clineno) {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #else
+ py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #endif
+ }
+ else {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromString(funcname);
+ #else
+ py_funcname = PyUnicode_FromString(funcname);
+ #endif
+ }
+ if (!py_funcname) goto bad;
+ py_globals = PyModule_GetDict(__pyx_m);
+ if (!py_globals) goto bad;
+ py_code = PyCode_New(
+ 0, /*int argcount,*/
+ #if PY_MAJOR_VERSION >= 3
+ 0, /*int kwonlyargcount,*/
+ #endif
+ 0, /*int nlocals,*/
+ 0, /*int stacksize,*/
+ 0, /*int flags,*/
+ __pyx_empty_bytes, /*PyObject *code,*/
+ __pyx_empty_tuple, /*PyObject *consts,*/
+ __pyx_empty_tuple, /*PyObject *names,*/
+ __pyx_empty_tuple, /*PyObject *varnames,*/
+ __pyx_empty_tuple, /*PyObject *freevars,*/
+ __pyx_empty_tuple, /*PyObject *cellvars,*/
+ py_srcfile, /*PyObject *filename,*/
+ py_funcname, /*PyObject *name,*/
+ __pyx_lineno, /*int firstlineno,*/
+ __pyx_empty_bytes /*PyObject *lnotab*/
+ );
+ if (!py_code) goto bad;
+ py_frame = PyFrame_New(
+ PyThreadState_GET(), /*PyThreadState *tstate,*/
+ py_code, /*PyCodeObject *code,*/
+ py_globals, /*PyObject *globals,*/
+ 0 /*PyObject *locals*/
+ );
+ if (!py_frame) goto bad;
+ py_frame->f_lineno = __pyx_lineno;
+ PyTraceBack_Here(py_frame);
+bad:
+ Py_XDECREF(py_srcfile);
+ Py_XDECREF(py_funcname);
+ Py_XDECREF(py_code);
+ Py_XDECREF(py_frame);
+}
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+ while (t->p) {
+ #if PY_MAJOR_VERSION < 3
+ if (t->is_unicode) {
+ *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+ } else if (t->intern) {
+ *t->p = PyString_InternFromString(t->s);
+ } else {
+ *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+ }
+ #else /* Python 3+ has unicode identifiers */
+ if (t->is_unicode | t->is_str) {
+ if (t->intern) {
+ *t->p = PyUnicode_InternFromString(t->s);
+ } else if (t->encoding) {
+ *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
+ } else {
+ *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
+ }
+ } else {
+ *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
+ }
+ #endif
+ if (!*t->p)
+ return -1;
+ ++t;
+ }
+ return 0;
+}
+
+/* Type Conversion Functions */
+
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+ int is_true = x == Py_True;
+ if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+ else return PyObject_IsTrue(x);
+}
+
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
+ PyNumberMethods *m;
+ const char *name = NULL;
+ PyObject *res = NULL;
+#if PY_VERSION_HEX < 0x03000000
+ if (PyInt_Check(x) || PyLong_Check(x))
+#else
+ if (PyLong_Check(x))
+#endif
+ return Py_INCREF(x), x;
+ m = Py_TYPE(x)->tp_as_number;
+#if PY_VERSION_HEX < 0x03000000
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Int(x);
+ }
+ else if (m && m->nb_long) {
+ name = "long";
+ res = PyNumber_Long(x);
+ }
+#else
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Long(x);
+ }
+#endif
+ if (res) {
+#if PY_VERSION_HEX < 0x03000000
+ if (!PyInt_Check(res) && !PyLong_Check(res)) {
+#else
+ if (!PyLong_Check(res)) {
+#endif
+ PyErr_Format(PyExc_TypeError,
+ "__%s__ returned non-%s (type %.200s)",
+ name, name, Py_TYPE(res)->tp_name);
+ Py_DECREF(res);
+ return NULL;
+ }
+ }
+ else if (!PyErr_Occurred()) {
+ PyErr_SetString(PyExc_TypeError,
+ "an integer is required");
+ }
+ return res;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+ Py_ssize_t ival;
+ PyObject* x = PyNumber_Index(b);
+ if (!x) return -1;
+ ival = PyInt_AsSsize_t(x);
+ Py_DECREF(x);
+ return ival;
+}
+
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+#if PY_VERSION_HEX < 0x02050000
+ if (ival <= LONG_MAX)
+ return PyInt_FromLong((long)ival);
+ else {
+ unsigned char *bytes = (unsigned char *) &ival;
+ int one = 1; int little = (int)*(unsigned char*)&one;
+ return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
+ }
+#else
+ return PyInt_FromSize_t(ival);
+#endif
+}
+
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
+ unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
+ if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
+ return (size_t)-1;
+ } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "value too large to convert to size_t");
+ return (size_t)-1;
+ }
+ return (size_t)val;
+}
+
+
+#endif /* Py_PYTHON_H */
-
cdef extern from "string.h":
ctypedef int size_t
void *memcpy(void *dst,void *src,size_t len)
void qsort(void *base, size_t nmemb, size_t size,
int (*compar)(void *,void *))
+cdef extern from "math.h":
+ double sqrt(double x)
+
cdef extern from "stdio.h":
ctypedef struct FILE:
pass
cdef extern from "Python.h":
long _Py_HashPointer(void*)
+ FILE* PyFile_AsFile(object)
+
+cdef extern from "fileobject.h":
+ ctypedef class __builtin__.file [object PyFileObject]:
+ pass
cdef extern from "razf.h":
pass
ctypedef int uint8_t
ctypedef int uint64_t
-
cdef extern from "bam.h":
+ # constants
+ int BAM_DEF_MASK
# IF _IOLIB=2, bamFile = BGZF, see bgzf.h
# samtools uses KNETFILE, check how this works
ctypedef struct bam_plbuf_t:
pass
+ ctypedef struct pair64_t:
+ uint64_t u, v
+
ctypedef struct bam_iter_t:
- pass
+ int from_first
+ int tid, beg, end, n_off, i, finished
+ uint64_t curr_off
+ pair64_t *off
+
+ # ctypedef __bam_iter_t * bam_iter_t
bam1_t * bam_init1()
void bam_destroy1(bam1_t *)
ctypedef struct bam_plp_t:
pass
+ ctypedef bam_pileup1_t * const_bam_pileup1_t_ptr "const bam_pileup1_t *"
+
ctypedef int (*bam_plp_auto_f)(void *data, bam1_t *b)
bam_plp_t bam_plp_init( bam_plp_auto_f func, void *data)
int bam_plp_push( bam_plp_t iter, bam1_t *b)
- bam_pileup1_t *bam_plp_next( bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
- bam_pileup1_t *bam_plp_auto( bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
+ bam_pileup1_t * bam_plp_next( bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
+ bam_pileup1_t * bam_plp_auto( bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
void bam_plp_set_mask(bam_plp_t iter, int mask)
void bam_plp_reset(bam_plp_t iter)
void bam_plp_destroy(bam_plp_t iter)
##################################################
- int bam_read1(bamFile fp, bam1_t *b)
-
+ int bam_read1( bamFile fp, bam1_t *b)
+ int bam_validate1( bam_header_t *header, bam1_t *b)
int bam_write1( bamFile fp, bam1_t *b)
bam_header_t *bam_header_init()
uint8_t *bam_aux_get(bam1_t *b, char tag[2])
- int bam_aux2i(uint8_t *s)
+ int32_t bam_aux2i(uint8_t *s)
float bam_aux2f(uint8_t *s)
double bam_aux2d(uint8_t *s)
char bam_aux2A( uint8_t *s)
uint32_t bam_calend(bam1_core_t *c, uint32_t *cigar)
+cdef extern from *:
+ ctypedef char* const_char_ptr "const char*"
+
cdef extern from "sam.h":
ctypedef struct samfile_t_un:
samfile_t_un x
bam_header_t *header
- samfile_t *samopen( char *fn, char * mode, void *aux)
+ samfile_t *samopen( const_char_ptr fn, char * mode, void *aux)
int sampileup( samfile_t *fp, int mask, bam_pileup_f func, void *data)
int samwrite(samfile_t *fp, bam1_t *b)
+ int bam_prob_realn(bam1_t *b, char *ref)
+ int bam_cap_mapQ(bam1_t *b, char *ref, int thres)
+
+
+cdef extern from "glf.h":
+ ctypedef struct glf1_t:
+ pass
+
+cdef extern from "bam_maqcns.h":
+
+ ctypedef struct bam_maqcns_t:
+ float het_rate, theta
+ int n_hap, cap_mapQ, errmod, min_baseQ
+ float eta, q_r
+ double *fk, *coef
+ double *lhet
+ void *aux
+
+ glf1_t *bam_maqcns_glfgen(int n,
+ bam_pileup1_t *pl,
+ uint8_t ref_base,
+ bam_maqcns_t *bm)
+
+ ctypedef struct bam_maqindel_opt_t:
+ int q_indel
+ float r_indel
+ float r_snp
+ int mm_penalty, indel_err, ambi_thres
+
+ uint32_t bam_maqcns_call(int n, bam_pileup1_t *pl, bam_maqcns_t *bm)
+ bam_maqcns_t * bam_maqcns_init()
+ void bam_maqcns_destroy(bam_maqcns_t *bm)
+ void bam_maqcns_prepare(bam_maqcns_t *bm)
+
+ uint32_t glf2cns(glf1_t *g, int q_r)
+
+ int BAM_ERRMOD_MAQ2
+ int BAM_ERRMOD_MAQ
+ int BAM_ERRMOD_SOAP
+
+ ctypedef struct bam_maqindel_ret_t:
+ int indel1
+ int indel2
+ int cnt1
+ int cnt2
+ int cnt_anti
+ int cnt_ref
+ int cnt_ambi
+ char *s[2]
+ int gt
+ int gl[2]
+ int q_cns
+ int q_ref
+
+ void bam_maqindel_ret_destroy( bam_maqindel_ret_t * )
+
+ bam_maqindel_opt_t *bam_maqindel_opt_init()
+
+ bam_maqindel_ret_t * bam_maqindel(int n,
+ int pos,
+ bam_maqindel_opt_t * mi,
+ bam_pileup1_t * pl,
+ char *ref,
+ int _n_types,
+ int * _types )
+
+
cdef extern from "faidx.h":
ctypedef struct faidx_t:
char *faidx_fetch_seq(faidx_t *fai, char *c_name,
int p_beg_i, int p_end_i, int *len)
+
cdef extern from "pysam_util.h":
int pysam_pileup_next(bam1_t *b,
# translate char to unsigned char
unsigned char pysam_translate_sequence( char s )
-
+ unsigned char * bam_nt16_table
+
+ int pysam_reference2tid( bam_header_t *header, char * s )
+
+ void pysam_set_stderr( FILE * file )
+
+ uint32_t pysam_glf_depth( glf1_t * g )
+
+ void pysam_dump_glf( glf1_t * g, bam_maqcns_t * c )
+
+# need to declare all C fields and methods here
+cdef class AlignedRead:
+
+ # object that this AlignedRead represents
+ cdef bam1_t * _delegate
+
+cdef class Samfile:
+ cdef char * _filename
+ # pointer to samfile
+ cdef samfile_t * samfile
+ # pointer to index
+ cdef bam_index_t *index
+ # true if file is a bam file
+ cdef int isbam
+ # true if file is not on the local filesystem
+ cdef int isremote
+ # current read within iteration
+ cdef bam1_t * b
+ # file opening mode
+ cdef char * mode
+
+ cdef bam_header_t * _buildHeader( self, new_header )
+ cdef bam1_t * getCurrent( self )
+ cdef int cnext(self)
+
+ # write an aligned read
+ cpdef int write( self, AlignedRead read )
+
+ cdef char * _getrname( self, int tid )
+
# cython: embedsignature=True
# cython: profile=True
# adds doc-strings for sphinx
-
-import tempfile, os, sys, types, itertools, struct, ctypes
-
-from python_string cimport PyString_FromStringAndSize, PyString_AS_STRING
-from python_exc cimport PyErr_SetString
+import tempfile
+import os
+import sys
+import types
+import itertools
+import struct
+import ctypes
+import collections
+import re
+import platform
+from cpython cimport PyString_FromStringAndSize, PyString_AS_STRING
+from cpython cimport PyErr_SetString
+
+#from cpython.string cimport PyString_FromStringAndSize, PyString_AS_STRING
+#from cpython.exc cimport PyErr_SetString, PyErr_NoMemory
# defines imported from samtools
DEF SEEK_SET = 0
DEF BAM_CHARD_CLIP = 5
DEF BAM_CPAD = 6
+#####################################################################
+# hard-coded constants
+cdef char * bam_nt16_rev_table = "=ACMGRSVTWYHKDBN"
+cdef int max_pos = 2 << 29
+
+# redirect stderr to 0
+_logfile = open(os.path.devnull, "w")
+pysam_set_stderr( PyFile_AsFile( _logfile ) )
+
#####################################################################
#####################################################################
#####################################################################
## private factory methods
#####################################################################
cdef class AlignedRead
-cdef makeAlignedRead( bam1_t * src):
+cdef makeAlignedRead(bam1_t * src):
'''enter src into AlignedRead.'''
- cdef AlignedRead dest
- dest = AlignedRead()
- # destroy dummy delegate created in constructor
- # to prevent memory leak.
- bam_destroy1(dest._delegate)
+ cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)
dest._delegate = bam_dup1(src)
return dest
cdef class PileupProxy
cdef makePileupProxy( bam_pileup1_t * plp, int tid, int pos, int n ):
- cdef PileupProxy dest
- dest = PileupProxy()
+ cdef PileupProxy dest = PileupProxy.__new__(PileupProxy)
dest.plp = plp
dest.tid = tid
dest.pos = pos
cdef class PileupRead
cdef makePileupRead( bam_pileup1_t * src ):
'''fill a PileupRead object from a bam_pileup1_t * object.'''
- cdef PileupRead dest
- dest = PileupRead()
+ cdef PileupRead dest = PileupRead.__new__(PileupRead)
dest._alignment = makeAlignedRead( src.b )
dest._qpos = src.qpos
dest._indel = src.indel
stderr is captured.
'''
def __init__(self):
+ return
self.stderr_h, self.stderr_f = tempfile.mkstemp()
self.stderr_save = Outs( sys.stderr.fileno() )
self.stderr_save.setfd( self.stderr_h )
def readAndRelease( self ):
+ return []
self.stderr_save.restore()
lines = []
if os.path.exists(self.stderr_f):
return lines
def release(self):
+ return
self.stderr_save.restore()
if os.path.exists(self.stderr_f):
os.remove( self.stderr_f )
def __del__(self):
self.release()
+class StderrStoreWindows():
+ '''does nothing. stderr can't be redirected on windows'''
+ def __init__(self): pass
+ def readAndRelease(self): return []
+ def release(self): pass
+
+if platform.system()=='Windows':
+ del StderrStore
+ StderrStore = StderrStoreWindows
+
+
######################################################################
######################################################################
######################################################################
VALID_HEADER_FIELDS = { "HD" : { "VN" : str, "SO" : str, "GO" : str },
"SQ" : { "SN" : str, "LN" : int, "AS" : str, "M5" : str, "UR" : str, "SP" : str },
"RG" : { "ID" : str, "SM" : str, "LB" : str, "DS" : str, "PU" : str, "PI" : str, "CN" : str, "DT" : str, "PL" : str, },
- "PG" : { "ID" : str, "VN" : str, "CL" : str }, }
+ "PG" : { "PN" : str, "ID" : str, "VN" : str, "CL" : str }, }
# output order of fields within records
VALID_HEADER_ORDER = { "HD" : ( "VN", "SO", "GO" ),
"SQ" : ( "SN", "LN", "AS", "M5" , "UR" , "SP" ),
"RG" : ( "ID", "SM", "LB", "DS" , "PU" , "PI" , "CN" , "DT", "PL" ),
- "PG" : ( "ID", "VN", "CL" ), }
+ "PG" : ( "PN", "ID", "VN", "CL" ), }
######################################################################
######################################################################
## Public methods
######################################################################
+cdef class Fastafile:
+ '''*(filename)*
+
+ A *FASTA* file. The file is automatically opened.
+
+ The file expects an indexed fasta file.
+
+ TODO:
+ add automatic indexing.
+ add function to get sequence names.
+ '''
+
+ cdef char * _filename
+ # pointer to fastafile
+ cdef faidx_t * fastafile
+
+ def __cinit__(self, *args, **kwargs ):
+ self.fastafile = NULL
+ self._filename = NULL
+ self._open( *args, **kwargs )
+
+ def _isOpen( self ):
+ '''return true if samfile has been opened.'''
+ return self.fastafile != NULL
+
+ def __len__(self):
+ if self.fastafile == NULL:
+ raise ValueError( "calling len() on closed file" )
+
+ return faidx_fetch_nseq(self.fastafile)
+
+ def _open( self,
+ char * filename ):
+ '''open an indexed fasta file.
+
+ This method expects an indexed fasta file.
+ '''
+
+ # close a previously opened file
+ if self.fastafile != NULL: self.close()
+ if self._filename != NULL: free(self._filename)
+ self._filename = strdup(filename)
+ self.fastafile = fai_load( filename )
+
+ if self.fastafile == NULL:
+ raise IOError("could not open file `%s`" % filename )
+
+ def close( self ):
+ if self.fastafile != NULL:
+ fai_destroy( self.fastafile )
+ self.fastafile = NULL
+
+ def __dealloc__(self):
+ self.close()
+ if self._filename != NULL: free(self._filename)
+
+ property filename:
+ '''number of :term:`filename` associated with this object.'''
+ def __get__(self):
+ if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
+ return self._filename
+
+ def fetch( self,
+ reference = None,
+ start = None,
+ end = None,
+ region = None):
+
+ '''*(reference = None, start = None, end = None, region = None)*
+
+ fetch :meth:`AlignedRead` objects in a :term:`region` using 0-based indexing.
+
+ The region is specified by :term:`reference`, *start* and *end*.
+
+ fetch returns an empty string if the region is out of range or addresses an unknown *reference*.
+
+ If *reference* is given and *start* is None, the sequence from the
+ first base is returned. Similarly, if *end* is None, the sequence
+ until the last base is returned.
+
+ Alternatively, a samtools :term:`region` string can be supplied.
+ '''
+
+ if not self._isOpen():
+ raise ValueError( "I/O operation on closed file" )
+
+ cdef int length
+ cdef char * seq
+
+ if not region:
+ if reference is None: raise ValueError( 'no sequence/region supplied.' )
+ if start is None: start = 0
+ if end is None: end = max_pos -1
+
+ if start > end: raise ValueError( 'invalid region: start (%i) > end (%i)' % (start, end) )
+ if start == end: return ""
+ # valid ranges are from 0 to 2^29-1
+ if not 0 <= start < max_pos: raise ValueError( 'start out of range (%i)' % start )
+ if not 0 <= end < max_pos: raise ValueError( 'end out of range (%i)' % end )
+ # note: faidx_fetch_seq has a bug such that out-of-range access
+ # always returns the last residue. Hence do not use faidx_fetch_seq,
+ # but use fai_fetch instead
+ # seq = faidx_fetch_seq(self.fastafile,
+ # reference,
+ # start,
+ # end-1,
+ # &length)
+ region = "%s:%i-%i" % (reference, start+1, end)
+ seq = fai_fetch( self.fastafile,
+ region,
+ &length )
+ else:
+ # samtools adds a '\0' at the end
+ seq = fai_fetch( self.fastafile, region, &length )
+
+ # copy to python
+ if seq == NULL:
+ return ""
+ else:
+ try:
+ py_seq = PyString_FromStringAndSize(seq, length)
+ finally:
+ free(seq)
+
+ return py_seq
+
+ cdef char * _fetch( self, char * reference, int start, int end, int * length ):
+ '''fetch sequence for reference, start and end'''
+
+ return faidx_fetch_seq(self.fastafile,
+ reference,
+ start,
+ end-1,
+ length )
+
+#------------------------------------------------------------------------
+#------------------------------------------------------------------------
+#------------------------------------------------------------------------
+cdef int count_callback( bam1_t *alignment, void *f):
+ '''callback for bam_fetch - count number of reads.
+ '''
+ cdef int* counter = (<int*>f)
+ counter[0] += 1;
+
+ctypedef struct MateData:
+ char * name
+ bam1_t * mate
+ uint32_t flag
+
+#------------------------------------------------------------------------
+#------------------------------------------------------------------------
+#------------------------------------------------------------------------
+cdef int mate_callback( bam1_t *alignment, void *f):
+ '''callback for bam_fetch = filter mate
+ '''
+ cdef MateData * d = (<MateData*>f)
+ # printf("mate = %p, name1 = %s, name2=%s\t%i\t%i\t%i\n",
+ # d.mate, d.name, bam1_qname(alignment),
+ # d.flag, alignment.core.flag, alignment.core.flag & d.flag)
+
+ if d.mate == NULL:
+ # could be sped up by comparing the lengths of query strings first
+ # using l_qname
+ #
+ # also, make sure that we get the other read by comparing
+ # the flags
+ if alignment.core.flag & d.flag != 0 and \
+ strcmp( bam1_qname( alignment ), d.name ) == 0:
+ d.mate = bam_dup1( alignment )
+
+
cdef class Samfile:
- '''*(filename, mode='r', template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*
+ '''*(filename, mode=None, template = None, referencenames = None, referencelengths = None, text = NULL, header = None)*
- A *SAM* file. The file is automatically opened.
+ A :term:`SAM`/:term:`BAM` formatted file. The file is automatically opened.
- *mode* should be ``r`` for reading or ``w`` for writing. The default is text mode so for binary
+ *mode* should be ``r`` for reading or ``w`` for writing. The default is text mode (:term:`SAM`). For binary
(:term:`BAM`) I/O you should append ``b`` for compressed or ``u`` for uncompressed :term:`BAM` output.
- Use ``h`` to output header information in text (:term:`TAM`) mode.
+ Use ``h`` to output header information in text (:term:`TAM`) mode.
If ``b`` is present, it must immediately follow ``r`` or ``w``.
- Currently valid modes are ``r``, ``w``, ``wh``, ``rb``, ``wb`` and ``wbu``.
-
- so to open a :term:`BAM` file for reading::
+ Valid modes are ``r``, ``w``, ``wh``, ``rb``, ``wb`` and ``wbu``. For instance, to open
+ a :term:`BAM` formatted file for reading, type::
- f=Samfile('ex1.bam','rb')
+ f = pysam.Samfile('ex1.bam','rb')
+ If mode is not specified, we will try to auto-detect in the order 'r', 'rb', thus both the following
+ should work::
- For writing, the header of a :term:`TAM` file/:term:`BAM` file can be constituted from several
- sources:
+ f1 = pysam.Samfile('ex1.bam' )
+ f2 = pysam.Samfile('ex1.bam' )
- 1. If *template* is given, the header is copied from a another *Samfile* (*template* must be of type *Samfile*).
+ If an index for a BAM file exists (.bai), it will be opened automatically. Without an index random
+ access to reads via :meth:`fetch` and :meth:`pileup` is disabled.
- 2. If *header* is given, the header is build from a multi-level dictionary. The first level are the four types ('HD', 'SQ', ...). The second level is then a list of lines, with each line being a list of tag-value pairs.
+ For writing, the header of a :term:`SAM` file/:term:`BAM` file can be constituted from several
+ sources (see also the samtools format specification):
+
+ 1. If *template* is given, the header is copied from a another *Samfile*
+ (*template* must be of type *Samfile*).
+
+ 2. If *header* is given, the header is built from a multi-level dictionary. The first level
+ are the four types ('HD', 'SQ', ...). The second level are a list of lines, with each line
+ being a list of tag-value pairs.
3. If *text* is given, new header text is copied from raw text.
4. The names (*referencenames*) and lengths (*referencelengths*) are supplied directly as lists.
- If an index for a BAM file exists (.bai), it will be opened automatically. Without an index random
- access to reads via :meth:`fetch` and :meth:`pileup` is disabled.
'''
- cdef char * filename
- # pointer to samfile
- cdef samfile_t * samfile
- # pointer to index
- cdef bam_index_t *index
- # true if file is a bam file
- cdef int isbam
- # true if file is not on the local filesystem
- cdef int isremote
- # current read within iteration
- cdef bam1_t * b
- # file opening mode
- cdef char * mode
-
def __cinit__(self, *args, **kwargs ):
self.samfile = NULL
+ self._filename = NULL
self.isbam = False
self._open( *args, **kwargs )
def _open( self,
char * filename,
- mode = 'r',
+ mode = None,
Samfile template = None,
referencenames = None,
referencelengths = None,
closed and a new file will be opened.
'''
+ # read mode autodetection
+ if mode is None:
+ try:
+ self._open(filename, 'r', template=template,
+ referencenames=referencenames,
+ referencelengths=referencelengths,
+ text=text, header=header, port=port)
+ return
+ except ValueError, msg:
+ pass
+ self._open(filename, 'rb', template=template,
+ referencenames=referencenames,
+ referencelengths=referencelengths,
+ text=text, header=header, port=port)
+ return
+
assert mode in ( "r","w","rb","wb", "wh", "wbu" ), "invalid file opening mode `%s`" % mode
+ assert filename != NULL
# close a previously opened file
if self.samfile != NULL: self.close()
cdef bam_header_t * header_to_write
header_to_write = NULL
-
- self.filename = filename
+
+ if self._filename != NULL: free(self._filename )
+ self._filename = strdup( filename )
self.isbam = len(mode) > 1 and mode[1] == 'b'
not os.path.exists( filename ):
raise IOError( "file `%s` not found" % filename)
- store = StderrStore()
+ # try to detect errors
self.samfile = samopen( filename, mode, NULL )
- result = store.readAndRelease()
- # test for specific messages as open also outputs status messages
- # that can be ignored.
- if "[bam_header_read] invalid BAM binary header (this is not a BAM file).\n" in result:
- raise ValueError( "invalid BAM binary header (is this a BAM file?)" )
- elif '[samopen] no @SQ lines in the header.\n' in result:
- raise ValueError( "no @SQ lines in the header (is this a SAM file?)")
+ if self.samfile == NULL:
+ raise ValueError( "could not open file (mode='%s') - is it SAM/BAM format?" % mode)
+
+ if self.samfile.header == NULL:
+ raise ValueError( "file does not have valid header (mode='%s') - is it SAM/BAM format?" % mode )
+
+ #disabled for autodetection to work
+ if self.samfile.header.n_targets == 0:
+ raise ValueError( "file header is empty (mode='%s') - is it SAM/BAM format?" % mode)
if self.samfile == NULL:
raise IOError("could not open file `%s`" % filename )
if self.index == NULL:
raise IOError("error while opening index `%s` " % filename )
+ def gettid( self, reference ):
+ '''
+ convert :term:`reference` name into numerical :term:`tid`
+
+ returns -1 if reference is not known.
+ '''
+ if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
+ return pysam_reference2tid( self.samfile.header, reference )
+
def getrname( self, tid ):
- '''(tid )
- convert numerical :term:`tid` into :ref:`reference` name.'''
+ '''
+ convert numerical :term:`tid` into :term:`reference` name.'''
+ if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
+ if not 0 <= tid < self.samfile.header.n_targets:
+ raise ValueError( "tid %i out of range 0<=tid<%i" % (tid, self.samfile.header.n_targets ) )
+ return self.samfile.header.target_name[tid]
+
+ cdef char * _getrname( self, int tid ):
+ '''
+ convert numerical :term:`tid` into :term:`reference` name.'''
if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
if not 0 <= tid < self.samfile.header.n_targets:
- raise ValueError( "tid out of range 0<=tid<%i" % self.samfile.header.n_targets )
+ raise ValueError( "tid %i out of range 0<=tid<%i" % (tid, self.samfile.header.n_targets ) )
return self.samfile.header.target_name[tid]
def _parseRegion( self,
reference = None,
start = None,
- end = None,
+ end = None,
region = None ):
- '''parse region information.
+ '''
+ parse region information.
- raise Value for for invalid regions.
+ raise ValueError for for invalid regions.
- returns a tuple of region, tid, start and end. Region
- is a valid samtools :term:`region` or None if the region
- extends over the whole file.
+ returns a tuple of flag, tid, start and end. Flag indicates
+ whether some coordinates were supplied.
Note that regions are 1-based, while start,end are python coordinates.
'''
# implementing it all in pysam (makes use of khash).
cdef int rtid
- cdef int rstart
- cdef int rend
- cdef int max_pos
- max_pos = 2 << 29
-
- rtid = rstart = rend = 0
+ cdef long long rstart
+ cdef long long rend
- # translate to a region
- if reference:
- if start != None and end != None:
- if start > end: raise ValueError( 'invalid region: start (%i) > end (%i)' % (start, end) )
- region = "%s:%i-%i" % (reference, start+1, end)
- else:
- region = reference
+ rtid = -1
+ rstart = 0
+ rend = max_pos
+ if start != None:
+ try:
+ rstart = start
+ except OverflowError:
+ raise ValueError( 'start out of range (%i)' % start )
+
+ if end != None:
+ try:
+ rend = end
+ except OverflowError:
+ raise ValueError( 'end out of range (%i)' % end )
if region:
- # this function might be called often (multiprocessing)
- # thus avoid using StderrStore, see issue 46.
- bam_parse_region( self.samfile.header, region, &rtid, &rstart, &rend)
- if rtid < 0: raise ValueError( "invalid region `%s`" % region )
- if rstart > rend: raise ValueError( 'invalid region: start (%i) > end (%i)' % (rstart, rend) )
- if not 0 <= rstart < max_pos: raise ValueError( 'start out of range (%i)' % rstart )
- if not 0 <= rend < max_pos: raise ValueError( 'end out of range (%i)' % rend )
-
- return region, rtid, rstart, rend
+ parts = re.split( "[:-]", region )
+ reference = parts[0]
+ if len(parts) >= 2: rstart = int(parts[1]) - 1
+ if len(parts) >= 3: rend = int(parts[2])
+
+ if not reference: return 0, 0, 0, 0
+
+ rtid = self.gettid( reference )
+ if rtid < 0: raise ValueError( "invalid reference `%s`" % reference )
+ if rstart > rend: raise ValueError( 'invalid coordinates: start (%i) > end (%i)' % (rstart, rend) )
+ if not 0 <= rstart < max_pos: raise ValueError( 'start out of range (%i)' % rstart )
+ if not 0 <= rend <= max_pos: raise ValueError( 'end out of range (%i)' % rend )
+
+ return 1, rtid, rstart, rend
def seek( self, uint64_t offset, int where = 0):
- '''move to current file to position *offset*'''
+ '''
+ move file pointer to position *offset*, see :meth:`pysam.Samfile.tell`.
+ '''
if not self._isOpen():
raise ValueError( "I/O operation on closed file" )
return bam_seek( self.samfile.x.bam, offset, where )
def tell( self ):
- '''return current file position'''
+ '''
+ return current file position
+ '''
if not self._isOpen():
raise ValueError( "I/O operation on closed file" )
if not self.isbam:
region = None,
callback = None,
until_eof = False ):
- '''*(reference = None, start = None, end = None, region = None, callback = None, until_eof = False)*
-
- fetch :meth:`AlignedRead` objects in a :term:`region` using 0-based indexing. The region is specified by
- :term:`reference`, *start* and *end*. Alternatively, a samtools :term:`region` string can be supplied.
+ '''
+ fetch aligned reads in a :term:`region` using 0-based indexing. The region is specified by
+ :term:`reference`, *start* and *end*. Alternatively, a samtools :term:`region` string can
+ be supplied.
Without *reference* or *region* all reads will be fetched. The reads will be returned
ordered by reference sequence, which will not necessarily be the order within the file.
If *until_eof* is given, all reads from the current file position will be returned
- *as they are sorted within the file*.
+ *in order as they are within the file*.
- If only *reference* is set, all reads matching on *reference* will be fetched.
+ If only *reference* is set, all reads aligned to *reference* will be fetched.
The method returns an iterator of type :class:`pysam.IteratorRow` unless
a *callback is provided. If *callback* is given, the callback will be executed
for each position within the :term:`region`. Note that callbacks currently work
only, if *region* or *reference* is given.
- Note that a :term:`TAM` file does not allow random access. If *region* or *reference* are given,
+ Note that a :term:`SAM` file does not allow random access. If *region* or *reference* are given,
an exception is raised.
'''
- cdef int rtid
- cdef int rstart
- cdef int rend
+ cdef int rtid, rstart, rend, has_coord
if not self._isOpen():
raise ValueError( "I/O operation on closed file" )
-
- region, rtid, rstart, rend = self._parseRegion( reference, start, end, region )
+ has_coord, rtid, rstart, rend = self._parseRegion( reference, start, end, region )
+
if self.isbam:
if not until_eof and not self._hasIndex() and not self.isremote:
raise ValueError( "fetch called on bamfile without index" )
if callback:
- if not region:
- raise ValueError( "callback functionality requires a region/reference" )
+ if not has_coord: raise ValueError( "callback functionality requires a region/reference" )
if not self._hasIndex(): raise ValueError( "no index available for fetch" )
return bam_fetch(self.samfile.x.bam,
self.index,
<void*>callback,
fetch_callback )
else:
- if region:
- return IteratorRow( self, rtid, rstart, rend )
+ if has_coord:
+ return IteratorRowRegion( self, rtid, rstart, rend )
else:
if until_eof:
return IteratorRowAll( self )
else:
- # return all targets by chaining the individual targets together.
- if not self._hasIndex(): raise ValueError( "no index available for fetch" )
- i = []
- rstart = 0
- rend = 1<<29
- for rtid from 0 <= rtid < self.nreferences:
- i.append( IteratorRow( self, rtid, rstart, rend))
- return itertools.chain( *i )
+ return IteratorRowAllRefs(self)
else:
# check if header is present - otherwise sam_read1 aborts
# this happens if a bamfile is opened with mode 'r'
else:
return IteratorRowAll( self )
- def pileup( self, reference = None, start = None, end = None, region = None, callback = None ):
- '''run a pileup within a :term:`region` using 0-based indexing. The region is specified by
- :term:`reference`, *start* and *end*. Alternatively, a samtools *region* string can be supplied.
+ def mate( self,
+ AlignedRead read ):
+ '''return the mate of :class:`AlignedRead` *read*.
- Without *reference* or *region* all reads will be fetched. The reads will be returned
+ Throws a ValueError if read is unpaired or the mate
+ is unmapped.
+
+ .. note::
+ Calling this method will change the file position.
+ This might interfere with any iterators that have
+ not re-opened the file.
+
+ '''
+ cdef uint32_t flag = read._delegate.core.flag
+
+ if flag & BAM_FPAIRED == 0:
+ raise ValueError( "read %s: is unpaired" % (read.qname))
+ if flag & BAM_FMUNMAP != 0:
+ raise ValueError( "mate %s: is unmapped" % (read.qname))
+
+ cdef MateData mate_data
+
+ mate_data.name = <char *>bam1_qname(read._delegate)
+ mate_data.mate = NULL
+ # xor flags to get the other mate
+ cdef int x = BAM_FREAD1 + BAM_FREAD2
+ mate_data.flag = ( flag ^ x) & x
+
+ bam_fetch(self.samfile.x.bam,
+ self.index,
+ read._delegate.core.mtid,
+ read._delegate.core.mpos,
+ read._delegate.core.mpos + 1,
+ <void*>&mate_data,
+ mate_callback )
+
+ if mate_data.mate == NULL:
+ raise ValueError( "mate not found" )
+
+ cdef AlignedRead dest = AlignedRead.__new__(AlignedRead)
+ dest._delegate = mate_data.mate
+ return dest
+
+ def count( self,
+ reference = None,
+ start = None,
+ end = None,
+ region = None,
+ until_eof = False ):
+ '''*(reference = None, start = None, end = None, region = None, callback = None, until_eof = False)*
+
+ count reads :term:`region` using 0-based indexing. The region is specified by
+ :term:`reference`, *start* and *end*. Alternatively, a samtools :term:`region` string can be supplied.
+
+ Note that a :term:`TAM` file does not allow random access. If *region* or *reference* are given,
+ an exception is raised.
+ '''
+ cdef int rtid
+ cdef int rstart
+ cdef int rend
+
+ if not self._isOpen():
+ raise ValueError( "I/O operation on closed file" )
+
+ region, rtid, rstart, rend = self._parseRegion( reference, start, end, region )
+
+ cdef int counter
+ counter = 0;
+
+ if self.isbam:
+ if not until_eof and not self._hasIndex() and not self.isremote:
+ raise ValueError( "fetch called on bamfile without index" )
+
+ if not region:
+ raise ValueError( "counting functionality requires a region/reference" )
+ if not self._hasIndex(): raise ValueError( "no index available for fetch" )
+ bam_fetch(self.samfile.x.bam,
+ self.index,
+ rtid,
+ rstart,
+ rend,
+ <void*>&counter,
+ count_callback )
+ return counter
+ else:
+ raise ValueError ("count for a region is not available for sam files" )
+
+ def pileup( self,
+ reference = None,
+ start = None,
+ end = None,
+ region = None,
+ callback = None,
+ **kwargs ):
+ '''
+ perform a :term:`pileup` within a :term:`region`. The region is specified by
+ :term:`reference`, *start* and *end* (using 0-based indexing).
+ Alternatively, a samtools *region* string can be supplied.
+
+ Without *reference* or *region* all reads will be used for the pileup. The reads will be returned
ordered by :term:`reference` sequence, which will not necessarily be the order within the file.
The method returns an iterator of type :class:`pysam.IteratorColumn` unless
- a *callback is provided. If *callback* is given, the callback will be executed
- for each position within the :term:`region`.
+ a *callback is provided. If a *callback* is given, the callback will be executed
+ for each column within the :term:`region`.
- Note that samfiles do not allow random access. If *region* or *reference* are given,
- an exception is raised.
+ Note that :term:`SAM` formatted files do not allow random access.
+ In these files, if a *region* or *reference* are given an exception is raised.
- .. Note::
+ Optional *kwargs* to the iterator:
+
+ stepper
+ The stepper controlls how the iterator advances.
+ Possible options for the stepper are
+
+ ``all``
+ use all reads for pileup.
+ ``samtools``
+ same filter and read processing as in :term:`csamtools` pileup
+
+ fastafile
+ A :class:`FastaFile` object
+
+ mask
+ Skip all reads with bits set in mask.
+
+
+ .. note::
*all* reads which overlap the region are returned. The first base returned will be the
first base of the first read *not* necessarily the first base of the region used in the query.
+
+ The maximum number of reads considered for pileup is *8000*. This limit is set by
+ :term:`csamtools`.
+
'''
- cdef int rtid
- cdef int rstart
- cdef int rend
+ cdef int rtid, rstart, rend, has_coord
cdef bam_plbuf_t *buf
if not self._isOpen():
raise ValueError( "I/O operation on closed file" )
- region, rtid, rstart, rend = self._parseRegion( reference, start, end, region )
-
+ has_coord, rtid, rstart, rend = self._parseRegion( reference, start, end, region )
+
if self.isbam:
if not self._hasIndex(): raise ValueError( "no index available for pileup" )
if callback:
- if not region:
- raise ValueError( "callback functionality requires a region/reference" )
+ if not has_coord: raise ValueError( "callback functionality requires a region/reference" )
buf = bam_plbuf_init( <bam_pileup_f>pileup_callback, <void*>callback )
bam_fetch(self.samfile.x.bam,
bam_plbuf_push( NULL, buf)
bam_plbuf_destroy(buf)
else:
- if region:
- return IteratorColumn( self, rtid, rstart, rend )
+ if has_coord:
+ return IteratorColumnRegion( self,
+ tid = rtid,
+ start = rstart,
+ end = rend,
+ **kwargs )
else:
- # return all targets by chaining the individual targets together.
- i = []
- rstart = 0
- rend = 1<<29
- for rtid from 0 <= rtid < self.nreferences:
- i.append( IteratorColumn( self, rtid, rstart, rend))
- return itertools.chain( *i )
+ return IteratorColumnAllRefs(self, **kwargs )
else:
raise NotImplementedError( "pileup of samfiles not implemented yet" )
def close( self ):
- '''closes file.'''
+ '''
+ closes the :class:`pysam.Samfile`.'''
if self.samfile != NULL:
samclose( self.samfile )
bam_index_destroy(self.index);
# note: __del__ is not called.
self.close()
bam_destroy1(self.b)
+ if self._filename != NULL: free( self._filename )
- def write( self, AlignedRead read ):
- '''(AlignedRead read )
- write a single :class:`pysam.AlignedRead`..
+ cpdef int write( self, AlignedRead read ) except -1:
+ '''
+ write a single :class:`pysam.AlignedRead` to disk.
- return the number of bytes written.
+ returns the number of bytes written.
'''
if not self._isOpen():
- raise ValueError( "I/O operation on closed file" )
+ return 0
return samwrite( self.samfile, read._delegate )
self.close()
return False
+ ###############################################################
+ ###############################################################
+ ###############################################################
+ ## properties
+ ###############################################################
+ property filename:
+ '''number of :term:`filename` associated with this object.'''
+ def __get__(self):
+ if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
+ return self._filename
+
property nreferences:
'''number of :term:`reference` sequences in the file.'''
def __get__(self):
return tuple(t)
property lengths:
- """tuple of the lengths of the :term:`reference` sequences. The lengths are in the same order as :attr:`pysam.Samfile.reference`
+ """tuple of the lengths of the :term:`reference` sequences. The lengths are in the same order as
+ :attr:`pysam.Samfile.references`
"""
def __get__(self):
if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
x = {}
for field in fields[1:]:
key, value = field.split(":",1)
- if key not in VALID_HEADER_FIELDS[record]:
+ # uppercase keys must be valid
+ # lowercase are permitted for user fields
+ if key in VALID_HEADER_FIELDS[record]:
+ x[key] = VALID_HEADER_FIELDS[record][key](value)
+ elif not key.isupper():
+ x[key] = value
+ else:
raise ValueError( "unknown field code '%s' in record '%s'" % (key, record) )
- x[key] = VALID_HEADER_FIELDS[record][key](value)
if VALID_HEADER_TYPES[record] == dict:
if record in result:
if record == "CO":
line.append( fields )
else:
+ # write fields of the specification
for key in VALID_HEADER_ORDER[record]:
if key in fields:
line.append( "%s:%s" % (key, str(fields[key])))
+ # write user fields
+ for key in fields:
+ if not key.isupper():
+ line.append( "%s:%s" % (key, str(fields[key])))
+
return "\t".join( line )
cdef bam_header_t * _buildHeader( self, new_header ):
return dest
+ ###############################################################
+ ###############################################################
+ ###############################################################
+ ## file-object like iterator access
+ ## note: concurrent access will cause errors (see IteratorRow
+ ## and reopen)
+ ## Possible solutions: deprecate or open new file handle
+ ###############################################################
def __iter__(self):
if not self._isOpen(): raise ValueError( "I/O operation on closed file" )
return self
return self.b
cdef int cnext(self):
- '''cversion of iterator. Used by IteratorColumn'''
+ '''
+ cversion of iterator. Used by :class:`pysam.Samfile.IteratorColumn`.
+ '''
cdef int ret
return samread(self.samfile, self.b)
def __next__(self):
- """python version of next().
-
- pyrex uses this non-standard name instead of next()
+ """
+ python version of next().
"""
cdef int ret
ret = samread(self.samfile, self.b)
else:
raise StopIteration
-cdef class Fastafile:
- '''*(filename)*
-
- A *FASTA* file. The file is automatically opened.
-
- The file expects an indexed fasta file.
-
- TODO:
- add automatic indexing.
- add function to get sequence names.
- '''
-
- cdef char * filename
- # pointer to fastafile
- cdef faidx_t * fastafile
-
- def __cinit__(self, *args, **kwargs ):
- self.fastafile = NULL
- self._open( *args, **kwargs )
-
- def _isOpen( self ):
- '''return true if samfile has been opened.'''
- return self.fastafile != NULL
-
- def __len__(self):
- if self.fastafile == NULL:
- raise ValueError( "calling len() on closed file" )
-
- return faidx_fetch_nseq(self.fastafile)
-
- def _open( self,
- char * filename ):
- '''open an indexed fasta file.
-
- This method expects an indexed fasta file.
- '''
-
- # close a previously opened file
- if self.fastafile != NULL: self.close()
- self.filename = filename
- self.fastafile = fai_load( filename )
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
+cdef class IteratorRow:
+ '''abstract base class for iterators over mapped reads.
- if self.fastafile == NULL:
- raise IOError("could not open file `%s`" % filename )
+ Various iterators implement different behaviours for wrapping around
+ contig boundaries. Examples include:
- def close( self ):
- if self.fastafile != NULL:
- fai_destroy( self.fastafile )
- self.fastafile = NULL
+ :class:`pysam.IteratorRowRegion`
+ iterate within a single contig and a defined region.
- def fetch( self,
- reference = None,
- start = None,
- end = None,
- region = None):
-
- '''*(reference = None, start = None, end = None, region = None)*
-
- fetch :meth:`AlignedRead` objects in a :term:`region` using 0-based indexing.
- The region is specified by :term:`reference`, *start* and *end*.
+ :class:`pysam.IteratorRowAll`
+ iterate until EOF. This iterator will also include unmapped reads.
- If *reference* is given and *start* is None, the sequence from the
- first base is returned. Similarly, if *end* is None, the sequence
- until the last base is returned.
-
- Alternatively, a samtools :term:`region` string can be supplied.
- '''
+ :class:`pysam.IteratorRowAllRefs`
+ iterate over all reads in all reference sequences.
- if not self._isOpen():
- raise ValueError( "I/O operation on closed file" )
-
- cdef int length, max_pos
- cdef char * seq
- max_pos = 2 << 29
-
- if not region:
- if reference is None: raise ValueError( 'no sequence/region supplied.' )
- if start is None: start = 0
- if end is None: end = max_pos -1
+ The method :meth:`Samfile.fetch` returns an IteratorRow.
+ '''
+ pass
- if start > end: raise ValueError( 'invalid region: start (%i) > end (%i)' % (start, end) )
- if start == end: return ""
- # valid ranges are from 0 to 2^29-1
- if not 0 <= start < max_pos: raise ValueError( 'start out of range (%i)' % start )
- if not 0 <= end < max_pos: raise ValueError( 'end out of range (%i)' % end )
- seq = faidx_fetch_seq(self.fastafile,
- reference,
- start,
- end-1,
- &length)
- else:
- # samtools adds a '\0' at the end
- seq = fai_fetch( self.fastafile, region, &length )
+cdef class IteratorRowRegion(IteratorRow):
+ """*(Samfile samfile, int tid, int beg, int end, int reopen = True )*
- # copy to python
- if seq == NULL:
- return ""
- else:
- try:
- py_seq = PyString_FromStringAndSize(seq, length)
- finally:
- free(seq)
+ iterate over mapped reads in a region.
- return py_seq
-
-###########################################################################
-###########################################################################
-###########################################################################
-## turning callbacks elegantly into iterators is an unsolved problem, see the following threads:
-## http://groups.google.com/group/comp.lang.python/browse_frm/thread/0ce55373f128aa4e/1d27a78ca6408134?hl=en&pli=1
-## http://www.velocityreviews.com/forums/t359277-turning-a-callback-function-into-a-generator.html
-## Thus I chose to rewrite the functions requiring callbacks. The downside is that if the samtools C-API or code
-## changes, the changes have to be manually entered.
-cdef class IteratorRow:
- """iterates over mapped reads in a region.
+ By default, the file is re-openend to avoid conflicts between
+ multiple iterators working on the same file. Set *reopen* = False
+ to not re-open *samfile*.
The samtools iterators assume that the file
position between iterations do not change.
cdef int retval
cdef Samfile samfile
cdef samfile_t * fp
+ # true if samfile belongs to this object
+ cdef int owns_samfile
- def __cinit__(self, Samfile samfile, int tid, int beg, int end ):
+ def __cinit__(self, Samfile samfile, int tid, int beg, int end, int reopen = True ):
if not samfile._isOpen():
raise ValueError( "I/O operation on closed file" )
if not samfile._hasIndex():
- raise ValueError( "no index available for pileup" )
+ raise ValueError( "no index available for iteration" )
# makes sure that samfile stays alive as long as the
# iterator is alive
if samfile.isbam: mode = "rb"
else: mode = "r"
- # reopen the file
- store = StderrStore()
- self.fp = samopen( samfile.filename, mode, NULL )
- store.release()
+ # reopen the file - note that this makes the iterator
+ # slow and causes pileup to slow down significantly.
+ if reopen:
+ store = StderrStore()
+ self.fp = samopen( samfile._filename, mode, NULL )
+ store.release()
+ assert self.fp != NULL
+ self.owns_samfile = True
+ else:
+ self.fp = self.samfile.samfile
+ self.owns_samfile = False
self.retval = 0
def __dealloc__(self):
bam_destroy1(self.b)
- samclose( self.fp )
+ if self.owns_samfile: samclose( self.fp )
-cdef class IteratorRowAll:
- """iterates over all mapped reads
+cdef class IteratorRowAll(IteratorRow):
+ """*(Samfile samfile, int reopen = True)*
+
+ iterate over all reads in *samfile*
+
+ By default, the file is re-openend to avoid conflicts between
+ multiple iterators working on the same file. Set *reopen* = False
+ to not re-open *samfile*.
"""
cdef bam1_t * b
cdef samfile_t * fp
+ # true if samfile belongs to this object
+ cdef int owns_samfile
- def __cinit__(self, Samfile samfile):
+ def __cinit__(self, Samfile samfile, int reopen = True ):
if not samfile._isOpen():
raise ValueError( "I/O operation on closed file" )
else: mode = "r"
# reopen the file to avoid iterator conflict
- store = StderrStore()
- self.fp = samopen( samfile.filename, mode, NULL )
- store.release()
+ if reopen:
+ store = StderrStore()
+ self.fp = samopen( samfile._filename, mode, NULL )
+ store.release()
+ assert self.fp != NULL
+ self.owns_samfile = True
+ else:
+ self.fp = samfile.samfile
+ self.owns_samfile = False
# allocate memory for alignment
self.b = <bam1_t*>calloc(1, sizeof(bam1_t))
def __dealloc__(self):
bam_destroy1(self.b)
- samclose( self.fp )
+ if self.owns_samfile: samclose( self.fp )
+
+cdef class IteratorRowAllRefs(IteratorRow):
+ """iterates over all mapped reads by chaining iterators over each reference
+ """
+ cdef Samfile samfile
+ cdef int tid
+ cdef IteratorRowRegion rowiter
+
+ def __cinit__(self, Samfile samfile):
+ assert samfile._isOpen()
+ if not samfile._hasIndex(): raise ValueError("no index available for fetch")
+ self.samfile = samfile
+ self.tid = -1
+
+ def nextiter(self):
+ self.rowiter = IteratorRowRegion(self.samfile, self.tid, 0, 1<<29)
+
+ def __iter__(self):
+ return self
+
+ def __next__(self):
+ """python version of next().
+
+ pyrex uses this non-standard name instead of next()
+ """
+ # Create an initial iterator
+ if self.tid==-1:
+ if not self.samfile.nreferences:
+ raise StopIteration
+ self.tid = 0
+ self.nextiter()
+
+ while 1:
+ self.rowiter.cnext()
+
+ # If current iterator is not exhausted, return aligned read
+ if self.rowiter.retval>0:
+ return makeAlignedRead(self.rowiter.b)
+
+ self.tid += 1
+
+ # Otherwise, proceed to next reference or stop
+ if self.tid<self.samfile.nreferences:
+ self.nextiter()
+ else:
+ raise StopIteration
+
+cdef class IteratorRowSelection(IteratorRow):
+ """*(Samfile samfile)*
+
+ iterate over reads in *samfile* at a given list of file positions.
+ """
+
+ cdef bam1_t * b
+ cdef int current_pos
+ cdef samfile_t * fp
+ cdef positions
+ # true if samfile belongs to this object
+ cdef int owns_samfile
+
+ def __cinit__(self, Samfile samfile, positions, int reopen = True ):
+
+ if not samfile._isOpen():
+ raise ValueError( "I/O operation on closed file" )
+
+ if not samfile._isOpen():
+ raise ValueError( "I/O operation on closed file" )
+
+ assert samfile.isbam, "can only use this iterator on bam files"
+ mode = "rb"
+
+ # reopen the file to avoid iterator conflict
+ if reopen:
+ store = StderrStore()
+ self.fp = samopen( samfile._filename, mode, NULL )
+ store.release()
+ assert self.fp != NULL
+ self.owns_samfile = True
+ else:
+ self.fp = samfile.samfile
+ self.owns_samfile = False
+
+ # allocate memory for alignment
+ self.b = <bam1_t*>calloc(1, sizeof(bam1_t))
+
+ self.positions = positions
+ self.current_pos = 0
+
+ def __iter__(self):
+ return self
+
+ cdef bam1_t * getCurrent( self ):
+ return self.b
+
+ cdef int cnext(self):
+ '''cversion of iterator'''
+
+ # end iteration if out of positions
+ if self.current_pos >= len(self.positions): return -1
+
+ bam_seek( self.fp.x.bam, self.positions[self.current_pos], 0 )
+ self.current_pos += 1
+ return samread(self.fp, self.b)
+
+ def __next__(self):
+ """python version of next().
+
+ pyrex uses this non-standard name instead of next()
+ """
+
+ cdef int ret = self.cnext()
+ if (ret > 0):
+ return makeAlignedRead( self.b )
+ else:
+ raise StopIteration
+
+ def __dealloc__(self):
+ bam_destroy1(self.b)
+ if self.owns_samfile: samclose( self.fp )
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
ctypedef struct __iterdata:
- bamFile fp
+ samfile_t * samfile
bam_iter_t iter
+ faidx_t * fastafile
+ int tid
+ char * seq
+ int seq_len
+
+cdef int __advance_all( void * data, bam1_t * b ):
+ '''advance without any read filtering.
+ '''
+ cdef __iterdata * d
+ d = <__iterdata*>data
+ return bam_iter_read( d.samfile.x.bam, d.iter, b )
-cdef int __advance( void * data, bam1_t * b ):
+cdef int __advance_snpcalls( void * data, bam1_t * b ):
+ '''advance using same filter and read processing as in
+ the samtools pileup.
+ '''
cdef __iterdata * d
d = <__iterdata*>data
- return bam_iter_read( d.fp, d.iter, b )
+
+ cdef int ret = bam_iter_read( d.samfile.x.bam, d.iter, b )
+ cdef int skip = 0
+ cdef int q
+ cdef int is_cns = 1
+ cdef int is_nobaq = 0
+ cdef int capQ_thres = 0
+
+ # reload sequence
+ if d.fastafile != NULL and b.core.tid != d.tid:
+ if d.seq != NULL: free(d.seq)
+ d.tid = b.core.tid
+ d.seq = faidx_fetch_seq(d.fastafile,
+ d.samfile.header.target_name[d.tid],
+ 0, max_pos,
+ &d.seq_len)
+ if d.seq == NULL:
+ raise ValueError( "reference sequence for '%s' (tid=%i) not found" % \
+ (d.samfile.header.target_name[d.tid],
+ d.tid))
+
+
+ while ret >= 0:
+
+ skip = 0
+
+ # realign read - changes base qualities
+ if d.seq != NULL and is_cns and not is_nobaq: bam_prob_realn( b, d.seq )
+
+ if d.seq != NULL and capQ_thres > 10:
+ q = bam_cap_mapQ(b, d.seq, capQ_thres)
+ if q < 0: skip = 1
+ elif b.core.qual > q: b.core.qual = q
+ if b.core.flag & BAM_FUNMAP: skip = 1
+ elif b.core.flag & 1 and not b.core.flag & 2: skip = 1
+
+ if not skip: break
+ # additional filters
+
+ ret = bam_iter_read( d.samfile.x.bam, d.iter, b )
+
+ return ret
cdef class IteratorColumn:
- '''iterates over columns.
+ '''abstract base class for iterators over columns.
- This iterator wraps the pileup functionality of samtools.
+ IteratorColumn objects wrap the pileup functionality of samtools.
- For reasons of efficiency, the iterator returns the current
- pileup buffer. As this buffer is updated at every iteration,
- the contents of this iterator will change accordingly. Hence the conversion to
- a list will not produce the expected result::
+ For reasons of efficiency, the iterator points to the current
+ pileup buffer. The pileup buffer is updated at every iteration.
+ This might cause some unexpected behavious. For example,
+ consider the conversion to a list::
f = Samfile("file.bam", "rb")
result = list( f.pileup() )
- Here, result will contain ``n`` objects of type :class:`PileupProxy` for ``n`` columns,
- but each object will contain the same information.
+ Here, ``result`` will contain ``n`` objects of type :class:`PileupProxy` for ``n`` columns,
+ but each object in ``result`` will contain the same information.
- If the results of several columns are required at the same time, the results
- need to be stored explicitely::
+ The desired behaviour can be achieved by list comprehension::
result = [ x.pileups() for x in f.pileup() ]
- Here, result will be a list of ``n`` lists of objects of type :class:`PileupRead`.
+ ``result`` will be a list of ``n`` lists of objects of type :class:`PileupRead`.
+
+ If the iterator is associated with a :class:`Fastafile` using the :meth:`addReference`
+ method, then the iterator will export the current sequence via the methods :meth:`getSequence`
+ and :meth:`seq_len`.
+ Optional kwargs to the iterator
+
+ stepper
+ The stepper controlls how the iterator advances.
+ Possible options for the stepper are
+
+ all
+ use all reads for pileup.
+ samtools
+ same filter and read processing as in :term:`csamtools` pileup
+ fastafile
+ A :class:`FastaFile` object
+ mask
+ Skip all reads with bits set in mask.
+
+
'''
# result of the last plbuf_push
- cdef IteratorRow iter
+ cdef IteratorRowRegion iter
cdef int tid
cdef int pos
cdef int n_plp
- cdef bam_pileup1_t * plp
+ cdef int mask
+ cdef const_bam_pileup1_t_ptr plp
cdef bam_plp_t pileup_iter
cdef __iterdata iterdata
- def __cinit__(self, Samfile samfile, int tid, int start, int end ):
-
- self.iter = IteratorRow( samfile, tid, start, end )
- self.iterdata.fp = samfile.samfile.x.bam
- self.iterdata.iter = self.iter.iter
+ cdef Samfile samfile
+ cdef Fastafile fastafile
+ cdef stepper
- self.pileup_iter = bam_plp_init( &__advance, &self.iterdata )
- self.n_plp = 0
+ def __cinit__( self, Samfile samfile, **kwargs ):
+ self.samfile = samfile
+ self.mask = kwargs.get("mask", BAM_DEF_MASK )
+ self.fastafile = kwargs.get( "fastafile", None )
+ self.stepper = kwargs.get( "stepper", None )
+ self.iterdata.seq = NULL
self.tid = 0
self.pos = 0
+ self.n_plp = 0
self.plp = NULL
+ self.pileup_iter = <bam_plp_t>NULL
def __iter__(self):
return self
- cdef int cnext(self):
- '''perform next iteration.
- '''
- self.plp = bam_plp_auto( self.pileup_iter,
- &self.tid,
- &self.pos,
- &self.n_plp )
+ cdef int cnext(self):
+ '''perform next iteration.
+
+ This method is analogous to the samtools bam_plp_auto method.
+ It has been re-implemented to permit for filtering.
+ '''
+ self.plp = bam_plp_auto( self.pileup_iter,
+ &self.tid,
+ &self.pos,
+ &self.n_plp )
+
+ cdef char * getSequence( self ):
+ '''return current reference sequence underlying the iterator.
+ '''
+ return self.iterdata.seq
+
+ property seq_len:
+ '''current sequence length.'''
+ def __get__(self): return self.iterdata.seq_len
+
+ def addReference( self, Fastafile fastafile ):
+ '''
+ add reference sequences in *fastafile* to iterator.'''
+ self.fastafile = fastafile
+ if self.iterdata.seq != NULL: free(self.iterdata.seq)
+ self.iterdata.tid = -1
+ self.iterdata.fastafile = self.fastafile.fastafile
+
+ def hasReference( self ):
+ '''
+ return true if iterator is associated with a reference'''
+ return self.fastafile
+
+ cdef setMask( self, mask ):
+ '''set masking flag in iterator.
+
+ reads with bits set in *mask* will be skipped.
+ '''
+ self.mask = mask
+ bam_plp_set_mask( self.pileup_iter, self.mask )
+
+ cdef setupIteratorData( self,
+ int tid,
+ int start,
+ int end,
+ int reopen = 0 ):
+ '''setup the iterator structure'''
+
+ self.iter = IteratorRowRegion( self.samfile, tid, start, end, reopen )
+ self.iterdata.samfile = self.samfile.samfile
+ self.iterdata.iter = self.iter.iter
+ self.iterdata.seq = NULL
+ self.iterdata.tid = -1
+
+ if self.fastafile != None:
+ self.iterdata.fastafile = self.fastafile.fastafile
+ else:
+ self.iterdata.fastafile = NULL
+
+ if self.stepper == None or self.stepper == "all":
+ self.pileup_iter = bam_plp_init( &__advance_all, &self.iterdata )
+ elif self.stepper == "samtools":
+ self.pileup_iter = bam_plp_init( &__advance_snpcalls, &self.iterdata )
+ else:
+ raise ValueError( "unknown stepper option `%s` in IteratorColumn" % self.stepper)
+
+ bam_plp_set_mask( self.pileup_iter, self.mask )
+
+ cdef reset( self, tid, start, end ):
+ '''reset iterator position.
+
+ This permits using the iterator multiple times without
+ having to incur the full set-up costs.
+ '''
+ self.iter = IteratorRowRegion( self.samfile, tid, start, end, reopen = 0 )
+ self.iterdata.iter = self.iter.iter
+
+ # invalidate sequence if different tid
+ if self.tid != tid:
+ if self.iterdata.seq != NULL: free( self.iterdata.seq )
+ self.iterdata.seq = NULL
+ self.iterdata.tid = -1
+
+ # self.pileup_iter = bam_plp_init( &__advancepileup, &self.iterdata )
+ bam_plp_reset(self.pileup_iter)
+
+ def __dealloc__(self):
+ # reset in order to avoid memory leak messages for iterators that have
+ # not been fully consumed
+ if self.pileup_iter != <bam_plp_t>NULL:
+ bam_plp_reset(self.pileup_iter)
+ bam_plp_destroy(self.pileup_iter)
+ self.pileup_iter = <bam_plp_t>NULL
+
+ if self.iterdata.seq != NULL:
+ free(self.iterdata.seq)
+ self.iterdata.seq = NULL
+
+cdef class IteratorColumnRegion(IteratorColumn):
+ '''iterates over a region only.
+ '''
+ def __cinit__(self, Samfile samfile,
+ int tid = 0,
+ int start = 0,
+ int end = max_pos,
+ **kwargs ):
+
+ # initialize iterator
+ self.setupIteratorData( tid, start, end, 1 )
+
+ def __next__(self):
+ """python version of next().
+ """
+
+ while 1:
+ self.cnext()
+ if self.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ if self.plp == NULL:
+ raise StopIteration
+
+ return makePileupProxy( <bam_pileup1_t*>self.plp,
+ self.tid,
+ self.pos,
+ self.n_plp )
+
+cdef class IteratorColumnAllRefs(IteratorColumn):
+ """iterates over all columns by chaining iterators over each reference
+ """
+
+ def __cinit__(self,
+ Samfile samfile,
+ **kwargs ):
+
+ # no iteration over empty files
+ if not samfile.nreferences: raise StopIteration
+
+ # initialize iterator
+ self.setupIteratorData( self.tid, 0, max_pos, 1 )
- def __next__(self):
+ def __next__(self):
"""python version of next().
-
- pyrex uses this non-standard name instead of next()
"""
- self.cnext()
- if self.n_plp < 0:
- raise ValueError("error during iteration" )
- if self.plp == NULL:
- raise StopIteration
-
- return makePileupProxy( self.plp, self.tid, self.pos, self.n_plp )
+ while 1:
+ self.cnext()
- def __dealloc__(self):
- bam_plp_destroy(self.pileup_iter)
+ if self.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ # return result, if within same reference
+ if self.plp != NULL:
+ return makePileupProxy( <bam_pileup1_t*>self.plp,
+ self.tid,
+ self.pos,
+ self.n_plp )
+
+ # otherwise, proceed to next reference or stop
+ self.tid += 1
+ if self.tid < self.samfile.nreferences:
+ self.setupIteratorData( self.tid, 0, max_pos, 0 )
+ else:
+ raise StopIteration
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
cdef inline int32_t query_start(bam1_t *src) except -1:
cdef uint32_t * cigar_p, op
cdef uint32_t k
return start_offset
-
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
+##-------------------------------------------------------------------
cdef inline int32_t query_end(bam1_t *src) except -1:
cdef uint32_t * cigar_p, op
cdef uint32_t k
cdef uint8_t * p
cdef uint32_t k
cdef char * s
- cdef char * bam_nt16_rev_table = "=ACMGRSVTWYHKDBN"
if not src.core.l_qseq:
return None
cdef class AlignedRead:
'''
- Class representing an aligned read. see SAM format specification for meaning of fields (http://samtools.sourceforge.net/).
+ Class representing an aligned read. see SAM format specification for
+ the meaning of fields (http://samtools.sourceforge.net/).
This class stores a handle to the samtools C-structure representing
an aligned read. Member read access is forwarded to the C-structure
be set *before* the quality scores. Setting the sequence will
also erase any quality scores that were set previously.
'''
- cdef:
- bam1_t * _delegate
- def __cinit__( self ):
+ # Now only called when instances are created from Python
+ def __init__(self):
# see bam_init1
self._delegate = <bam1_t*>calloc( 1, sizeof( bam1_t) )
# allocate some memory
bam_destroy1(self._delegate)
def __str__(self):
- """todo"""
+ """return string representation of alignment.
+
+ The representation is an approximate :term:`sam` format.
+
+ An aligned read might not be associated with a :term:`Samfile`.
+ As a result :term:`tid` is shown instead of the reference name.
+
+ Similarly, the tags field is returned in its parsed state.
+ """
+ # sam-parsing is done in sam.c/bam_format1_core which
+ # requires a valid header.
return "\t".join(map(str, (self.qname,
+ self.flag,
self.rname,
self.pos,
+ self.mapq,
self.cigar,
- self.qual,
- self.flag,
+ self.mrnm,
+ self.mpos,
+ self.rlen,
self.seq,
- self.mapq,
- self.tags)))
-
+ self.qual,
+ self.tags )))
def compare(self, AlignedRead other):
'''return -1,0,1, if contents in this are binary <,=,> to *other*'''
pysam_bam_update( src,
src.core.n_cigar * 4,
len(values) * 4,
- p )
+ <uint8_t*>p )
# length is number of cigar operations, not bytes
src.core.n_cigar = len(values)
def __get__(self):
cdef bam1_t * src
cdef char * s
-
src = self._delegate
if src.core.l_qseq == 0: return None
for pytag, value in tags:
t = type(value)
if t == types.FloatType:
- fmt = "<cccf"
+ fmt, pytype = "<cccf", 'f'
elif t == types.IntType:
if value < 0:
if value >= -127: fmt, pytype = "<cccb", 'c'
elif value >= -32767: fmt, pytype = "<ccch", 's'
elif value < -2147483648: raise ValueError( "integer %i out of range of BAM/SAM specification" % value )
- else: fmt, ctype = "<ccci", 'i'[0]
+ else: fmt, pytype = "<ccci", 'i'[0]
else:
if value <= 255: fmt, pytype = "<cccB", 'C'
elif value <= 65535: fmt, pytype = "<cccH", 'S'
"""properties flag"""
def __get__(self): return self._delegate.core.flag
def __set__(self, flag): self._delegate.core.flag = flag
+
property rname:
"""
:term:`target` ID
+ DEPRECATED from pysam-0.4 - use tid in the future.
+ The rname field caused a lot of confusion as it returns
+ the :term:`target` ID instead of the reference sequence
+ name.
+
.. note::
This field contains the index of the reference sequence
in the sequence dictionary. To obtain the name
of the reference sequence, use :meth:`pysam.Samfile.getrname()`
+
+ """
+ def __get__(self): return self._delegate.core.tid
+ def __set__(self, tid): self._delegate.core.tid = tid
+
+ property tid:
+ """
+ :term:`target` ID
+
+ .. note::
+ This field contains the index of the reference sequence
+ in the sequence dictionary. To obtain the name
+ of the reference sequence, use :meth:`pysam.Samfile.getrname()`
+
"""
def __get__(self): return self._delegate.core.tid
def __set__(self, tid): self._delegate.core.tid = tid
+
property pos:
"""0-based leftmost coordinate"""
def __get__(self): return self._delegate.core.pos
else: self._delegate.core.flag &= ~BAM_FMUNMAP
property is_reverse:
"""true if read is mapped to reverse strand"""
- def __get__(self):return (self.flag & BAM_FREVERSE) != 0
+ def __get__(self): return (self.flag & BAM_FREVERSE) != 0
def __set__(self,val):
if val: self._delegate.core.flag |= BAM_FREVERSE
else: self._delegate.core.flag &= ~BAM_FREVERSE
if val: self._delegate.core.flag |= BAM_FQCFAIL
else: self._delegate.core.flag &= ~BAM_FQCFAIL
property is_duplicate:
- """ true if optical or PCR duplicate"""
+ """true if optical or PCR duplicate"""
def __get__(self): return (self.flag & BAM_FDUP) != 0
def __set__(self,val):
if val: self._delegate.core.flag |= BAM_FDUP
else: self._delegate.core.flag &= ~BAM_FDUP
-
+ property positions:
+ """a list of reference positions that this read aligns to."""
+ def __get__(self):
+ cdef uint32_t k, i, pos
+ cdef int op
+ cdef uint32_t * cigar_p
+ cdef bam1_t * src
+
+ result = []
+ src = self._delegate
+ if src.core.n_cigar == 0: return []
+
+ pos = src.core.pos
+
+ cigar_p = bam1_cigar(src)
+ for k from 0 <= k < src.core.n_cigar:
+ op = cigar_p[k] & BAM_CIGAR_MASK
+ l = cigar_p[k] >> BAM_CIGAR_SHIFT
+ if op == BAM_CMATCH:
+ for i from pos <= i < pos + l:
+ result.append( i )
+
+ if op == BAM_CMATCH or op == BAM_CDEL or op == BAM_CREF_SKIP:
+ pos += l
+
+ return result
+ def overlap( self, uint32_t start, uint32_t end ):
+ """return number of bases on reference overlapping *start* and *end*
+ """
+ cdef uint32_t k, i, pos, overlap
+ cdef int op, o
+ cdef uint32_t * cigar_p
+ cdef bam1_t * src
+
+ overlap = 0
+
+ src = self._delegate
+ if src.core.n_cigar == 0: return 0
+ pos = src.core.pos
+ o = 0
+
+ cigar_p = bam1_cigar(src)
+ for k from 0 <= k < src.core.n_cigar:
+ op = cigar_p[k] & BAM_CIGAR_MASK
+ l = cigar_p[k] >> BAM_CIGAR_SHIFT
+
+ if op == BAM_CMATCH:
+ o = min( pos + l, end) - max( pos, start )
+ if o > 0: overlap += o
+
+ if op == BAM_CMATCH or op == BAM_CDEL or op == BAM_CREF_SKIP:
+ pos += l
+
+ return overlap
+
def opt(self, tag):
"""retrieves optional data given a two-letter *tag*"""
#see bam_aux.c: bam_aux_get() and bam_aux2i() etc
v = bam_aux_get(self._delegate, tag)
if v == NULL: raise KeyError( "tag '%s' not present" % tag )
type = chr(v[0])
- if type == 'c' or type == 'C' or type == 's' or type == 'S' or type == 'i':
+ if type == 'c' or type == 'C' or type == 's' or type == 'S':
return <int>bam_aux2i(v)
- elif type == 'f':
+ elif type == 'i' or type == 'I':
+ return <int32_t>bam_aux2i(v)
+ elif type == 'f' or type == 'F':
return <float>bam_aux2f(v)
- elif type == 'd':
+ elif type == 'd' or type == 'D':
return <double>bam_aux2d(v)
elif type == 'A':
# there might a more efficient way
cdef int pos
cdef int n_pu
- def __cinit__(self ):
- pass
+ def __init__(self):
+ raise TypeError("This class cannot be instantiated from Python")
def __str__(self):
return "\t".join( map(str, (self.tid, self.pos, self.n))) +\
uint32_t _is_head
uint32_t _is_tail
- def __cinit__( self ):
- pass
+ def __init__(self):
+ raise TypeError("This class cannot be instantiated from Python")
def __str__(self):
return "\t".join( map(str, (self.alignment, self.qpos, self.indel, self.level, self.is_del, self.is_head, self.is_tail ) ) )
ofd = os.dup(self.id) # Save old stream on new unit.
self.streams.append(ofd)
sys.stdout.flush() # Buffered data goes to old stream.
+ sys.stderr.flush() # Buffered data goes to old stream.
os.dup2(fd, self.id) # Open unit 1 on new stream.
os.close(fd) # Close other unit (look out, caller.)
os.close(self.streams[-1])
del self.streams[-1]
-def _samtools_dispatch( method, args = () ):
+def _samtools_dispatch( method,
+ args = (),
+ catch_stdout = True,
+ catch_stderr = False,
+ ):
'''call ``method`` in samtools providing arguments in args.
.. note::
# note that debugging this module can be a problem
# as stdout/stderr will not appear
+ # some special cases
+ if method == "index":
+ if not os.path.exists( args[0] ):
+ raise IOError( "No such file or directory: '%s'" % args[0] )
+
# redirect stderr and stdout to file
+ if catch_stderr:
+ stderr_h, stderr_f = tempfile.mkstemp()
+ stderr_save = Outs( sys.stderr.fileno() )
+ stderr_save.setfd( stderr_h )
- # open files and redirect into it
- stderr_h, stderr_f = tempfile.mkstemp()
- stdout_h, stdout_f = tempfile.mkstemp()
+ if catch_stdout:
+ stdout_h, stdout_f = tempfile.mkstemp()
+ stdout_save = Outs( sys.stdout.fileno() )
+ stdout_save.setfd( stdout_h )
- # patch for `samtools view`
- # samtools `view` closes stdout, from which I can not
- # recover. Thus redirect output to file with -o option.
- if method == "view":
- if "-o" in args: raise ValueError("option -o is forbidden in samtools view")
- args = ( "-o", stdout_f ) + args
+ # patch for `samtools view`
+ # samtools `view` closes stdout, from which I can not
+ # recover. Thus redirect output to file with -o option.
+ if method == "view":
+ if "-o" in args: raise ValueError("option -o is forbidden in samtools view")
+ args = ( "-o", stdout_f ) + args
- stdout_save = Outs( sys.stdout.fileno() )
- stdout_save.setfd( stdout_h )
- stderr_save = Outs( sys.stderr.fileno() )
- stderr_save.setfd( stderr_h )
# do the function call to samtools
cdef char ** cargs
# restore stdout/stderr. This will also flush, so
# needs to be before reading back the file contents
- stdout_save.restore()
- stderr_save.restore()
+ if catch_stdout:
+ stdout_save.restore()
+ out_stdout = open( stdout_f, "r").readlines()
+ os.remove( stdout_f )
+ else:
+ out_stdout = []
+
+ if catch_stderr:
+ stderr_save.restore()
+ out_stderr = open( stderr_f, "r").readlines()
+ os.remove( stderr_f )
+ else:
+ out_stderr = []
+
+ return retval, out_stderr, out_stdout
+
+cdef class SNPCall:
+ '''the results of a SNP call.'''
+ cdef int _tid
+ cdef int _pos
+ cdef char _reference_base
+ cdef char _genotype
+ cdef int _consensus_quality
+ cdef int _snp_quality
+ cdef int _rms_mapping_quality
+ cdef int _coverage
- # capture stderr/stdout.
- out_stderr = open( stderr_f, "r").readlines()
- out_stdout = open( stdout_f, "r").readlines()
+ property tid:
+ '''the chromosome ID as is defined in the header'''
+ def __get__(self):
+ return self._tid
+
+ property pos:
+ '''nucleotide position of SNP.'''
+ def __get__(self): return self._pos
- # clean up files
- os.remove( stderr_f )
- os.remove( stdout_f )
+ property reference_base:
+ '''reference base at pos. ``N`` if no reference sequence supplied.'''
+ def __get__(self): return PyString_FromStringAndSize( &self._reference_base, 1 )
- return retval, out_stderr, out_stdout
+ property genotype:
+ '''the genotype called.'''
+ def __get__(self): return PyString_FromStringAndSize( &self._genotype, 1 )
+
+ property consensus_quality:
+ '''the genotype quality (Phred-scaled).'''
+ def __get__(self): return self._consensus_quality
+
+ property snp_quality:
+ '''the snp quality (Phred scaled) - probability of consensus being identical to reference sequence.'''
+ def __get__(self): return self._snp_quality
+
+ property mapping_quality:
+ '''the root mean square (rms) of the mapping quality of all reads involved in the call.'''
+ def __get__(self): return self._rms_mapping_quality
+
+ property coverage:
+ '''coverage or read depth - the number of reads involved in the call.'''
+ def __get__(self): return self._coverage
+
+ def __str__(self):
+
+ return "\t".join( map(str, (
+ self.tid,
+ self.pos,
+ self.reference_base,
+ self.genotype,
+ self.consensus_quality,
+ self.snp_quality,
+ self.mapping_quality,
+ self.coverage ) ) )
+
+
+cdef class SNPCallerBase:
+ '''Base class for SNP callers.
+
+ *min_baseQ*
+ minimum base quality (possibly capped by BAQ)
+ *capQ_threshold*
+ coefficient for adjusting mapQ of poor mappings
+ *theta*
+ theta in maq consensus calling model
+ *n_haplotypes*
+ number of haplotypes in the sample
+ *het_rate*
+ prior of a difference between two haplotypes
+ '''
+
+ cdef bam_maqcns_t * c
+ cdef IteratorColumn iter
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+
+ self.iter = iterator_column
+ self.c = bam_maqcns_init()
+
+ # set the default parameterization according to
+ # samtools
+
+ # new default mode for samtools >0.1.10
+ self.c.errmod = kwargs.get( "errmod", BAM_ERRMOD_MAQ2 )
+
+ self.c.min_baseQ = kwargs.get( "min_baseQ", 13 )
+ # self.c.capQ_thres = kwargs.get( "capQ_threshold", 60 )
+ self.c.n_hap = kwargs.get( "n_haplotypes", 2 )
+ self.c.het_rate = kwargs.get( "het_rate", 0.001 )
+ self.c.theta = kwargs.get( "theta", 0.83 )
+
+ if self.c.errmod != BAM_ERRMOD_MAQ2:
+ self.c.theta += 0.02
+
+ # call prepare AFTER setting parameters
+ bam_maqcns_prepare( self.c )
+
+ def __dealloc__(self):
+ bam_maqcns_destroy( self.c )
+
+ cdef __dump( self, glf1_t * g, uint32_t cns, int rb ):
+ '''debugging output.'''
+
+ pysam_dump_glf( g, self.c );
+ print ""
+ for x in range(self.iter.n_plp):
+ print "--> read %i %s %i" % (x,
+ bam1_qname(self.iter.plp[x].b),
+ self.iter.plp[x].qpos,
+ )
+
+ print "pos=%i, cns=%i, q_r = %f, depth=%i, n=%i, rb=%i, cns-cq=%i %i %i %i" \
+ % (self.iter.pos,
+ cns,
+ self.c.q_r,
+ self.iter.n_plp,
+ self.iter.n_plp,
+ rb,
+ cns >> 8 & 0xff,
+ cns >> 16 & 0xff,
+ cns & 0xff,
+ cns >> 28,
+ )
+
+ printf("-------------------------------------\n");
+ sys.stdout.flush()
+
+cdef class IteratorSNPCalls( SNPCallerBase ):
+ """*(IteratorColumn iterator)*
+
+ call SNPs within a region.
+
+ *iterator* is a pileup iterator. SNPs will be called
+ on all positions returned by this iterator.
+
+ This caller is fast if SNPs are called over large continuous
+ regions. It is slow, if instantiated frequently and in random
+ order as the sequence will have to be reloaded.
+
+ """
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+
+ assert self.iter.hasReference(), "IteratorSNPCalls requires an pileup iterator with reference sequence"
+
+ def __iter__(self):
+ return self
+
+ def __next__(self):
+ """python version of next().
+ """
+
+ # the following code was adapted from bam_plcmd.c:pileup_func()
+ self.iter.cnext()
+
+ if self.iter.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ if self.iter.plp == NULL:
+ raise StopIteration
+
+ cdef char * seq = self.iter.getSequence()
+ cdef int seq_len = self.iter.seq_len
+
+ assert seq != NULL
+
+ # reference base
+ if self.iter.pos >= seq_len:
+ raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
+
+ cdef int rb = seq[self.iter.pos]
+ cdef uint32_t cns
+ cdef glf1_t * g
+
+ g = bam_maqcns_glfgen( self.iter.n_plp,
+ self.iter.plp,
+ bam_nt16_table[rb],
+ self.c )
+
+ if pysam_glf_depth( g ) == 0:
+ cns = 0xfu << 28 | 0xf << 24
+ else:
+ cns = glf2cns(g, <int>(self.c.q_r + .499))
+
+ free(g)
+
+ cdef SNPCall call
+
+ call = SNPCall()
+ call._tid = self.iter.tid
+ call._pos = self.iter.pos
+ call._reference_base = rb
+ call._genotype = bam_nt16_rev_table[cns>>28]
+ call._consensus_quality = cns >> 8 & 0xff
+ call._snp_quality = cns & 0xff
+ call._rms_mapping_quality = cns >> 16&0xff
+ call._coverage = self.iter.n_plp
+
+ return call
+
+cdef class SNPCaller( SNPCallerBase ):
+ '''*(IteratorColumn iterator_column )*
+
+ The samtools SNP caller.
+
+ This object will call SNPs in *samfile* against the reference
+ sequence in *fasta*.
+
+ This caller is fast for calling few SNPs in selected regions.
+
+ It is slow, if called over large genomic regions.
+ '''
+
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+
+ pass
+
+ def call(self, reference, int pos ):
+ """call a snp on chromosome *reference*
+ and position *pos*.
+
+ returns a :class:`SNPCall` object.
+ """
+
+ cdef int tid = self.iter.samfile.gettid( reference )
+
+ self.iter.reset( tid, pos, pos + 1 )
+
+ while 1:
+ self.iter.cnext()
+
+ if self.iter.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ if self.iter.plp == NULL:
+ raise ValueError( "no reads in region - no call" )
+
+ if self.iter.pos == pos: break
+
+ cdef char * seq = self.iter.getSequence()
+ cdef int seq_len = self.iter.seq_len
+
+ assert seq != NULL
+
+ # reference base
+ if self.iter.pos >= seq_len:
+ raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
+
+ cdef int rb = seq[self.iter.pos]
+ cdef uint32_t cns
+ cdef glf1_t * g
+
+ g = bam_maqcns_glfgen( self.iter.n_plp,
+ self.iter.plp,
+ bam_nt16_table[rb],
+ self.c )
+
+
+ if pysam_glf_depth( g ) == 0:
+ cns = 0xfu << 28 | 0xf << 24
+ else:
+ cns = glf2cns(g, <int>(self.c.q_r + .499))
+
+ free(g)
+
+ cdef SNPCall call
+
+ call = SNPCall()
+ call._tid = self.iter.tid
+ call._pos = self.iter.pos
+ call._reference_base = rb
+ call._genotype = bam_nt16_rev_table[cns>>28]
+ call._consensus_quality = cns >> 8 & 0xff
+ call._snp_quality = cns & 0xff
+ call._rms_mapping_quality = cns >> 16&0xff
+ call._coverage = self.iter.n_plp
+
+ return call
+
+cdef class IndelCall:
+ '''the results of an indel call.'''
+ cdef int _tid
+ cdef int _pos
+ cdef int _coverage
+ cdef int _rms_mapping_quality
+ cdef bam_maqindel_ret_t * _r
+
+ def __cinit__(self):
+ #assert r != NULL
+ #self._r = r
+ pass
+
+ property tid:
+ '''the chromosome ID as is defined in the header'''
+ def __get__(self):
+ return self._tid
+
+ property pos:
+ '''nucleotide position of SNP.'''
+ def __get__(self): return self._pos
+
+ property genotype:
+ '''the genotype called.'''
+ def __get__(self):
+ if self._r.gt == 0:
+ s = PyString_FromStringAndSize( self._r.s[0], self._r.indel1 + 1)
+ return "%s/%s" % (s,s)
+ elif self._r.gt == 1:
+ s = PyString_FromStringAndSize( self._r.s[1], self._r.indel2 + 1)
+ return "%s/%s" % (s,s)
+ else:
+ return "%s/%s" % (self.first_allele, self.second_allele )
+
+ property consensus_quality:
+ '''the genotype quality (Phred-scaled).'''
+ def __get__(self): return self._r.q_cns
+
+ property snp_quality:
+ '''the snp quality (Phred scaled) - probability of consensus being identical to reference sequence.'''
+ def __get__(self): return self._r.q_ref
+
+ property mapping_quality:
+ '''the root mean square (rms) of the mapping quality of all reads involved in the call.'''
+ def __get__(self): return self._rms_mapping_quality
+
+ property coverage:
+ '''coverage or read depth - the number of reads involved in the call.'''
+ def __get__(self): return self._coverage
+
+ property first_allele:
+ '''sequence of first allele.'''
+ def __get__(self): return PyString_FromStringAndSize( self._r.s[0], self._r.indel1 + 1)
+
+ property second_allele:
+ '''sequence of second allele.'''
+ def __get__(self): return PyString_FromStringAndSize( self._r.s[1], self._r.indel2 + 1)
+
+ property reads_first:
+ '''reads supporting first allele.'''
+ def __get__(self): return self._r.cnt1
+
+ property reads_second:
+ '''reads supporting first allele.'''
+ def __get__(self): return self._r.cnt2
+
+ property reads_diff:
+ '''reads supporting first allele.'''
+ def __get__(self): return self._r.cnt_anti
+
+ def __str__(self):
+
+ return "\t".join( map(str, (
+ self.tid,
+ self.pos,
+ self.genotype,
+ self.consensus_quality,
+ self.snp_quality,
+ self.mapping_quality,
+ self.coverage,
+ self.first_allele,
+ self.second_allele,
+ self.reads_first,
+ self.reads_second,
+ self.reads_diff ) ) )
+
+ def __dealloc__(self ):
+ bam_maqindel_ret_destroy(self._r)
+
+cdef class IndelCallerBase:
+ '''Base class for SNP callers.
+
+ *min_baseQ*
+ minimum base quality (possibly capped by BAQ)
+ *capQ_threshold*
+ coefficient for adjusting mapQ of poor mappings
+ *theta*
+ theta in maq consensus calling model
+ *n_haplotypes*
+ number of haplotypes in the sample
+ *het_rate*
+ prior of a difference between two haplotypes
+ '''
+
+ cdef bam_maqindel_opt_t * options
+ cdef IteratorColumn iter
+ cdef int cap_mapQ
+ cdef int max_depth
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+
+
+ self.iter = iterator_column
+
+ assert iterator_column.hasReference(), "IndelCallerBase requires an pileup iterator with reference sequence"
+
+ self.options = bam_maqindel_opt_init()
+
+ # set the default parameterization according to
+ # samtools
+
+ self.options.r_indel = kwargs.get( "r_indel", 0.00015 )
+ self.options.q_indel = kwargs.get( "q_indel", 40 )
+ self.cap_mapQ = kwargs.get( "cap_mapQ", 60 )
+ self.max_depth = kwargs.get( "max_depth", 1024 )
+
+ def __dealloc__(self):
+ free( self.options )
+
+ def _call( self ):
+
+ cdef char * seq = self.iter.getSequence()
+ cdef int seq_len = self.iter.seq_len
+
+ assert seq != NULL
+
+ # reference base
+ if self.iter.pos >= seq_len:
+ raise ValueError( "position %i out of bounds on reference sequence (len=%i)" % (self.iter.pos, seq_len) )
+
+ cdef bam_maqindel_ret_t * r
+
+ cdef int m = min( self.max_depth, self.iter.n_plp )
+
+ # printf("pysam: m=%i, q_indel=%i, r_indel=%f, r_snp=%i, mm_penalty=%i, indel_err=%i, ambi_thres=%i\n",
+ # m, self.options.q_indel, self.options.r_indel, self.options.r_snp, self.options.mm_penalty,
+ # self.options.indel_err, self.options.ambi_thres );
+
+ r = bam_maqindel(m,
+ self.iter.pos,
+ self.options,
+ self.iter.plp,
+ seq,
+ 0,
+ NULL)
+
+ if r == NULL: return None
+
+ cdef IndelCall call
+ call = IndelCall()
+ call._r = r
+ call._tid = self.iter.tid
+ call._pos = self.iter.pos
+ call._coverage = self.iter.n_plp
+
+ cdef uint64_t rms_aux = 0
+ cdef int i = 0
+ cdef bam_pileup1_t * p
+ cdef int tmp
+
+ for i from 0 <= i < self.iter.n_plp:
+ p = self.iter.plp + i
+ if p.b.core.qual < self.cap_mapQ:
+ tmp = p.b.core.qual
+ else:
+ tmp = self.cap_mapQ
+ rms_aux += tmp * tmp
+
+ call._rms_mapping_quality = <uint64_t>(sqrt(<double>rms_aux / self.iter.n_plp) + .499)
+
+ return call
+
+cdef class IndelCaller( IndelCallerBase ):
+ '''*(IteratorColumn iterator_column )*
+
+ The samtools SNP caller.
+
+ This object will call SNPs in *samfile* against the reference
+ sequence in *fasta*.
+
+ This caller is fast for calling few SNPs in selected regions.
+
+ It is slow, if called over large genomic regions.
+ '''
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+
+ pass
+
+ def call(self, reference, int pos ):
+ """call a snp on chromosome *reference*
+ and position *pos*.
+
+ returns a :class:`SNPCall` object or None, if no indel call could be made.
+ """
+
+ cdef int tid = self.iter.samfile.gettid( reference )
+
+ self.iter.reset( tid, pos, pos + 1 )
+
+ while 1:
+ self.iter.cnext()
+
+ if self.iter.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ if self.iter.plp == NULL:
+ raise ValueError( "no reads in region - no call" )
+
+ if self.iter.pos == pos: break
+
+ return self._call()
+
+cdef class IteratorIndelCalls( IndelCallerBase ):
+ """*(IteratorColumn iterator)*
+
+ call indels within a region.
+
+ *iterator* is a pileup iterator. SNPs will be called
+ on all positions returned by this iterator.
+
+ This caller is fast if SNPs are called over large continuous
+ regions. It is slow, if instantiated frequently and in random
+ order as the sequence will have to be reloaded.
+
+ """
+
+ def __cinit__(self,
+ IteratorColumn iterator_column,
+ **kwargs ):
+ pass
+
+
+ def __iter__(self):
+ return self
+
+ def __next__(self):
+ """python version of next().
+ """
+
+ # the following code was adapted from bam_plcmd.c:pileup_func()
+ self.iter.cnext()
+
+ if self.iter.n_plp < 0:
+ raise ValueError("error during iteration" )
+
+ if self.iter.plp == NULL:
+ raise StopIteration
+
+ return self._call()
+
+
+
+cdef class IndexedReads:
+ """index a bamfile by read.
+
+ The index is kept in memory.
+
+ By default, the file is re-openend to avoid conflicts if
+ multiple operators work on the same file. Set *reopen* = False
+ to not re-open *samfile*.
+ """
+
+ cdef Samfile samfile
+ cdef samfile_t * fp
+ cdef index
+ # true if samfile belongs to this object
+ cdef int owns_samfile
+
+ def __init__(self, Samfile samfile, int reopen = True ):
+ self.samfile = samfile
+
+ if samfile.isbam: mode = "rb"
+ else: mode = "r"
+
+ # reopen the file - note that this makes the iterator
+ # slow and causes pileup to slow down significantly.
+ if reopen:
+ store = StderrStore()
+ self.fp = samopen( samfile._filename, mode, NULL )
+ store.release()
+ assert self.fp != NULL
+ self.owns_samfile = True
+ else:
+ self.fp = samfile.samfile
+ self.owns_samfile = False
+
+ assert samfile.isbam, "can only IndexReads on bam files"
+
+ def build( self ):
+ '''build index.'''
+
+ self.index = collections.defaultdict( list )
+
+ # this method will start indexing from the current file position
+ # if you decide
+ cdef int ret = 1
+ cdef bam1_t * b = <bam1_t*> calloc(1, sizeof( bam1_t) )
+
+ cdef uint64_t pos
+
+ while ret > 0:
+ pos = bam_tell( self.fp.x.bam )
+ ret = samread( self.fp, b)
+ if ret > 0:
+ qname = bam1_qname( b )
+ self.index[qname].append( pos )
+
+ bam_destroy1( b )
+
+ def find( self, qname ):
+ if qname in self.index:
+ return IteratorRowSelection( self.samfile, self.index[qname], reopen = False )
+ else:
+ raise KeyError( "read %s not found" % qname )
+
+ def __dealloc__(self):
+ if self.owns_samfile: samclose( self.fp )
__all__ = ["Samfile",
"Fastafile",
"IteratorRow",
- "IteratorRowAll",
"IteratorColumn",
"AlignedRead",
"PileupColumn",
"PileupProxy",
- "PileupRead" ]
+ "PileupRead",
+ "IteratorSNPCalls",
+ "SNPCaller",
+ "IndelCaller",
+ "IteratorIndelCalls",
+ "IndexedReads" ]
--- /dev/null
+/* Generated by Cython 0.13 on Thu May 5 14:57:46 2011 */
+
+#define PY_SSIZE_T_CLEAN
+#include "Python.h"
+#ifndef Py_PYTHON_H
+ #error Python headers needed to compile C extensions, please install development version of Python.
+#else
+
+#include <stddef.h> /* For offsetof */
+#ifndef offsetof
+#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
+#endif
+
+#if !defined(WIN32) && !defined(MS_WINDOWS)
+ #ifndef __stdcall
+ #define __stdcall
+ #endif
+ #ifndef __cdecl
+ #define __cdecl
+ #endif
+ #ifndef __fastcall
+ #define __fastcall
+ #endif
+#endif
+
+#ifndef DL_IMPORT
+ #define DL_IMPORT(t) t
+#endif
+#ifndef DL_EXPORT
+ #define DL_EXPORT(t) t
+#endif
+
+#ifndef PY_LONG_LONG
+ #define PY_LONG_LONG LONG_LONG
+#endif
+
+#if PY_VERSION_HEX < 0x02040000
+ #define METH_COEXIST 0
+ #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
+ #define PyDict_Contains(d,o) PySequence_Contains(d,o)
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ typedef int Py_ssize_t;
+ #define PY_SSIZE_T_MAX INT_MAX
+ #define PY_SSIZE_T_MIN INT_MIN
+ #define PY_FORMAT_SIZE_T ""
+ #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
+ #define PyInt_AsSsize_t(o) PyInt_AsLong(o)
+ #define PyNumber_Index(o) PyNumber_Int(o)
+ #define PyIndex_Check(o) PyNumber_Check(o)
+ #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
+ #define Py_TYPE(ob) (((PyObject*)(ob))->ob_type)
+ #define Py_SIZE(ob) (((PyVarObject*)(ob))->ob_size)
+ #define PyVarObject_HEAD_INIT(type, size) \
+ PyObject_HEAD_INIT(type) size,
+ #define PyType_Modified(t)
+
+ typedef struct {
+ void *buf;
+ PyObject *obj;
+ Py_ssize_t len;
+ Py_ssize_t itemsize;
+ int readonly;
+ int ndim;
+ char *format;
+ Py_ssize_t *shape;
+ Py_ssize_t *strides;
+ Py_ssize_t *suboffsets;
+ void *internal;
+ } Py_buffer;
+
+ #define PyBUF_SIMPLE 0
+ #define PyBUF_WRITABLE 0x0001
+ #define PyBUF_FORMAT 0x0004
+ #define PyBUF_ND 0x0008
+ #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
+ #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
+ #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
+ #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
+ #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
+
+#endif
+
+#if PY_MAJOR_VERSION < 3
+ #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
+#else
+ #define __Pyx_BUILTIN_MODULE_NAME "builtins"
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define Py_TPFLAGS_CHECKTYPES 0
+ #define Py_TPFLAGS_HAVE_INDEX 0
+#endif
+
+#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
+ #define Py_TPFLAGS_HAVE_NEWBUFFER 0
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBaseString_Type PyUnicode_Type
+ #define PyStringObject PyUnicodeObject
+ #define PyString_Type PyUnicode_Type
+ #define PyString_Check PyUnicode_Check
+ #define PyString_CheckExact PyUnicode_CheckExact
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define PyBytesObject PyStringObject
+ #define PyBytes_Type PyString_Type
+ #define PyBytes_Check PyString_Check
+ #define PyBytes_CheckExact PyString_CheckExact
+ #define PyBytes_FromString PyString_FromString
+ #define PyBytes_FromStringAndSize PyString_FromStringAndSize
+ #define PyBytes_FromFormat PyString_FromFormat
+ #define PyBytes_DecodeEscape PyString_DecodeEscape
+ #define PyBytes_AsString PyString_AsString
+ #define PyBytes_AsStringAndSize PyString_AsStringAndSize
+ #define PyBytes_Size PyString_Size
+ #define PyBytes_AS_STRING PyString_AS_STRING
+ #define PyBytes_GET_SIZE PyString_GET_SIZE
+ #define PyBytes_Repr PyString_Repr
+ #define PyBytes_Concat PyString_Concat
+ #define PyBytes_ConcatAndDel PyString_ConcatAndDel
+ #define PySet_Check(obj) PyObject_TypeCheck(obj, &PySet_Type)
+ #define PyFrozenSet_Check(obj) PyObject_TypeCheck(obj, &PyFrozenSet_Type)
+#endif
+
+#ifndef PySet_CheckExact
+# define PySet_CheckExact(obj) (Py_TYPE(obj) == &PySet_Type)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyInt_Type PyLong_Type
+ #define PyInt_Check(op) PyLong_Check(op)
+ #define PyInt_CheckExact(op) PyLong_CheckExact(op)
+ #define PyInt_FromString PyLong_FromString
+ #define PyInt_FromUnicode PyLong_FromUnicode
+ #define PyInt_FromLong PyLong_FromLong
+ #define PyInt_FromSize_t PyLong_FromSize_t
+ #define PyInt_FromSsize_t PyLong_FromSsize_t
+ #define PyInt_AsLong PyLong_AsLong
+ #define PyInt_AS_LONG PyLong_AS_LONG
+ #define PyInt_AsSsize_t PyLong_AsSsize_t
+ #define PyInt_AsUnsignedLongMask PyLong_AsUnsignedLongMask
+ #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBoolObject PyLongObject
+#endif
+
+
+#if PY_MAJOR_VERSION >= 3
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_TrueDivide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceTrueDivide(x,y)
+#else
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_Divide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceDivide(x,y)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),((char *)(n)))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),((char *)(n)))
+#else
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),(n))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),(n))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_NAMESTR(n) ((char *)(n))
+ #define __Pyx_DOCSTR(n) ((char *)(n))
+#else
+ #define __Pyx_NAMESTR(n) (n)
+ #define __Pyx_DOCSTR(n) (n)
+#endif
+
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+
+#if defined(WIN32) || defined(MS_WINDOWS)
+#define _USE_MATH_DEFINES
+#endif
+#include <math.h>
+#define __PYX_HAVE_API__ctabix
+#include "string.h"
+#include "stdlib.h"
+#include "stdio.h"
+#include "ctype.h"
+#include "sys/types.h"
+#include "sys/stat.h"
+#include "fcntl.h"
+#include "unistd.h"
+#include "stdint.h"
+#include "bgzf.h"
+#include "tabix.h"
+#include "pythread.h"
+
+/* inline attribute */
+#ifndef CYTHON_INLINE
+ #if defined(__GNUC__)
+ #define CYTHON_INLINE __inline__
+ #elif defined(_MSC_VER)
+ #define CYTHON_INLINE __inline
+ #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+ #define CYTHON_INLINE inline
+ #else
+ #define CYTHON_INLINE
+ #endif
+#endif
+
+/* unused attribute */
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+# if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+# elif defined(__ICC) || defined(__INTEL_COMPILER)
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+#endif
+
+typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
+
+
+/* Type Conversion Predeclarations */
+
+#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
+#define __Pyx_PyBytes_AsUString(s) ((unsigned char*) PyBytes_AsString(s))
+
+#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
+
+#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
+
+
+#ifdef __GNUC__
+/* Test for GCC > 2.95 */
+#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95))
+#define likely(x) __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* __GNUC__ > 2 ... */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ > 2 ... */
+#else /* __GNUC__ */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+
+static PyObject *__pyx_m;
+static PyObject *__pyx_b;
+static PyObject *__pyx_empty_tuple;
+static PyObject *__pyx_empty_bytes;
+static int __pyx_lineno;
+static int __pyx_clineno = 0;
+static const char * __pyx_cfilenm= __FILE__;
+static const char *__pyx_filename;
+
+
+static const char *__pyx_f[] = {
+ "ctabix.pyx",
+ "bool.pxd",
+ "TabProxies.pxd",
+};
+
+/* Type declarations */
+
+/* "pysam/ctabix.pxd":178
+ * cdef tabix_t * tabixfile
+ *
+ * cdef class Parser: # <<<<<<<<<<<<<<
+ * pass
+ */
+
+struct __pyx_obj_6ctabix_Parser {
+ PyObject_HEAD
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":293
+ * return r
+ *
+ * cdef class asVCF( Parser ): # <<<<<<<<<<<<<<
+ * '''converts a :term:`tabix row` into a VCF record.'''
+ * def __call__(self, char * buffer, int len ):
+ */
+
+struct __pyx_obj_6ctabix_asVCF {
+ struct __pyx_obj_6ctabix_Parser __pyx_base;
+};
+
+/* "pysam/TabProxies.pxd":42
+ * ctypedef int uint64_t
+ *
+ * cdef class TupleProxy: # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_TupleProxy {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtab;
+ char *data;
+ char **fields;
+ int nfields;
+ int index;
+ int nbytes;
+ int offset;
+ int is_modified;
+};
+
+/* "pysam/TabProxies.pxd":77
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class NamedTupleProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ * pass
+ *
+ */
+
+struct __pyx_obj_10TabProxies_NamedTupleProxy {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+};
+
+/* "pysam/TabProxies.pxd":80
+ * pass
+ *
+ * cdef class BedProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_BedProxy {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+ char *contig;
+ uint32_t start;
+ uint32_t end;
+ int bedfields;
+};
+
+/* "pysam/TabProxies.pxd":91
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class VCFProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_VCFProxy {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+ char *contig;
+ uint32_t pos;
+};
+
+/* "pysam/TabProxies.pxd":60
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class GTFProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_GTFProxy {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+ char *contig;
+ char *source;
+ char *feature;
+ uint32_t start;
+ uint32_t end;
+ char *score;
+ char *strand;
+ char *frame;
+ char *attributes;
+ int hasOwnAttributes;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":161
+ * return result
+ *
+ * cdef class TabixIterator: # <<<<<<<<<<<<<<
+ * """iterates over rows in *tabixfile* in region
+ * given by *tid*, *start* and *end*.
+ */
+
+struct __pyx_obj_6ctabix_TabixIterator {
+ PyObject_HEAD
+ ti_iter_t iterator;
+ tabix_t *tabixfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":304
+ * #########################################################
+ * #########################################################
+ * cdef class TabixIteratorParsed: # <<<<<<<<<<<<<<
+ * """iterates over mapped reads in a region.
+ *
+ */
+
+struct __pyx_obj_6ctabix_TabixIteratorParsed {
+ PyObject_HEAD
+ ti_iter_t iterator;
+ tabix_t *tabixfile;
+ struct __pyx_obj_6ctabix_Parser *parser;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":216
+ * ti_iter_destroy(self.iterator)
+ *
+ * cdef class TabixHeaderIterator: # <<<<<<<<<<<<<<
+ * """return header lines.
+ * """
+ */
+
+struct __pyx_obj_6ctabix_TabixHeaderIterator {
+ PyObject_HEAD
+ ti_iter_t iterator;
+ tabix_t *tabixfile;
+};
+
+/* "pysam/ctabix.pxd":172
+ * # char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
+ *
+ * cdef class Tabixfile: # <<<<<<<<<<<<<<
+ * cdef char * filename
+ *
+ */
+
+struct __pyx_obj_6ctabix_Tabixfile {
+ PyObject_HEAD
+ char *filename;
+ tabix_t *tabixfile;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":277
+ * return r
+ *
+ * cdef class asGTF(Parser): # <<<<<<<<<<<<<<
+ * '''converts a :term:`tabix row` into a GTF record.'''
+ * def __call__(self, char * buffer, int len):
+ */
+
+struct __pyx_obj_6ctabix_asGTF {
+ struct __pyx_obj_6ctabix_Parser __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":285
+ * return r
+ *
+ * cdef class asBed( Parser ): # <<<<<<<<<<<<<<
+ * '''converts a :term:`tabix row` into a GTF record.'''
+ * def __call__(self, char * buffer, int len):
+ */
+
+struct __pyx_obj_6ctabix_asBed {
+ struct __pyx_obj_6ctabix_Parser __pyx_base;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/ctabix.pyx":267
+ * pass
+ *
+ * cdef class asTuple(Parser): # <<<<<<<<<<<<<<
+ * '''converts a :term:`tabix row` into a python tuple.'''
+ * def __call__(self, char * buffer, int len):
+ */
+
+struct __pyx_obj_6ctabix_asTuple {
+ struct __pyx_obj_6ctabix_Parser __pyx_base;
+};
+
+
+/* "pysam/TabProxies.pxd":42
+ * ctypedef int uint64_t
+ *
+ * cdef class TupleProxy: # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_TupleProxy {
+ int (*getMaxFields)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t);
+ PyObject *(*take)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*present)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*copy)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*update)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+};
+static struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtabptr_10TabProxies_TupleProxy;
+
+
+/* "pysam/TabProxies.pxd":77
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class NamedTupleProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ * pass
+ *
+ */
+
+struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy {
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+
+
+/* "pysam/TabProxies.pxd":91
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class VCFProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_VCFProxy {
+ struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_VCFProxy *__pyx_vtabptr_10TabProxies_VCFProxy;
+
+
+/* "pysam/TabProxies.pxd":80
+ * pass
+ *
+ * cdef class BedProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_BedProxy {
+ struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_BedProxy *__pyx_vtabptr_10TabProxies_BedProxy;
+
+
+/* "pysam/TabProxies.pxd":60
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class GTFProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_GTFProxy {
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_GTFProxy *__pyx_vtabptr_10TabProxies_GTFProxy;
+
+#ifndef CYTHON_REFNANNY
+ #define CYTHON_REFNANNY 0
+#endif
+
+#if CYTHON_REFNANNY
+ typedef struct {
+ void (*INCREF)(void*, PyObject*, int);
+ void (*DECREF)(void*, PyObject*, int);
+ void (*GOTREF)(void*, PyObject*, int);
+ void (*GIVEREF)(void*, PyObject*, int);
+ void* (*SetupContext)(const char*, int, const char*);
+ void (*FinishContext)(void**);
+ } __Pyx_RefNannyAPIStruct;
+ static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
+ static __Pyx_RefNannyAPIStruct * __Pyx_RefNannyImportAPI(const char *modname) {
+ PyObject *m = NULL, *p = NULL;
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+ m = PyImport_ImportModule((char *)modname);
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+ p = PyObject_GetAttrString(m, (char *)"RefNannyAPI");
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+ end:
+ Py_XDECREF(p);
+ Py_XDECREF(m);
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+ #define __Pyx_RefNannySetupContext(name) void *__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__)
+ #define __Pyx_RefNannyFinishContext() __Pyx_RefNanny->FinishContext(&__pyx_refnanny)
+ #define __Pyx_INCREF(r) __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_DECREF(r) __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_GOTREF(r) __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_XDECREF(r) do { if((r) != NULL) {__Pyx_DECREF(r);} } while(0)
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+ #define __Pyx_RefNannySetupContext(name)
+ #define __Pyx_RefNannyFinishContext()
+ #define __Pyx_INCREF(r) Py_INCREF(r)
+ #define __Pyx_DECREF(r) Py_DECREF(r)
+ #define __Pyx_GOTREF(r)
+ #define __Pyx_GIVEREF(r)
+ #define __Pyx_XDECREF(r) Py_XDECREF(r)
+#endif /* CYTHON_REFNANNY */
+#define __Pyx_XGIVEREF(r) do { if((r) != NULL) {__Pyx_GIVEREF(r);} } while(0)
+#define __Pyx_XGOTREF(r) do { if((r) != NULL) {__Pyx_GOTREF(r);} } while(0)
+
+static PyObject *__Pyx_GetName(PyObject *dict, PyObject *name); /*proto*/
+
+static CYTHON_INLINE int __Pyx_CheckKeywordStrings(PyObject *kwdict,
+ const char* function_name, int kw_allowed); /*proto*/
+
+static void __Pyx_RaiseDoubleKeywordsError(
+ const char* func_name, PyObject* kw_name); /*proto*/
+
+static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
+ Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found); /*proto*/
+
+static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[], PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args, const char* function_name); /*proto*/
+
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
+ PyObject *r;
+ if (!j) return NULL;
+ r = PyObject_GetItem(o, j);
+ Py_DECREF(j);
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+}
+
+
+#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
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+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ PyObject *r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Tuple_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ PyObject *r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+
+#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
+ r = PySequence_GetItem(o, i);
+ }
+ else {
+ r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+ }
+ return r;
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
+
+static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
+static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
+
+static int __Pyx_ArgTypeTest(PyObject *obj, PyTypeObject *type, int none_allowed,
+ const char *name, int exact); /*proto*/
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
+
+
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
+ PyObject *value;
+ if (unlikely(d == Py_None)) {
+ __Pyx_RaiseNoneIndexingError();
+ return NULL;
+ }
+ value = PyDict_GetItemWithError(d, key);
+ if (unlikely(!value)) {
+ if (!PyErr_Occurred())
+ PyErr_SetObject(PyExc_KeyError, key);
+ return NULL;
+ }
+ Py_INCREF(value);
+ return value;
+}
+#else
+ #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
+#endif
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject *);
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
+
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict); /*proto*/
+
+static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr); /*proto*/
+
+static void __Pyx_AddTraceback(const char *funcname); /*proto*/
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
+/* Module declarations from cpython.version */
+
+/* Module declarations from cpython.ref */
+
+/* Module declarations from cpython.exc */
+
+/* Module declarations from cpython.module */
+
+/* Module declarations from cpython.mem */
+
+/* Module declarations from cpython.tuple */
+
+/* Module declarations from cpython.list */
+
+/* Module declarations from libc.stdio */
+
+/* Module declarations from cpython.object */
+
+/* Module declarations from cpython.sequence */
+
+/* Module declarations from cpython.mapping */
+
+/* Module declarations from cpython.iterator */
+
+/* Module declarations from cpython.type */
+
+/* Module declarations from cpython.number */
+
+/* Module declarations from cpython.int */
+
+/* Module declarations from __builtin__ */
+
+/* Module declarations from cpython.bool */
+
+static PyTypeObject *__pyx_ptype_7cpython_4bool_bool = 0;
+/* Module declarations from cpython.long */
+
+/* Module declarations from cpython.float */
+
+/* Module declarations from cpython.complex */
+
+/* Module declarations from cpython.string */
+
+/* Module declarations from cpython.unicode */
+
+/* Module declarations from cpython.dict */
+
+/* Module declarations from cpython.instance */
+
+/* Module declarations from cpython.function */
+
+/* Module declarations from cpython.method */
+
+/* Module declarations from cpython.weakref */
+
+/* Module declarations from cpython.getargs */
+
+/* Module declarations from cpython.pythread */
+
+/* Module declarations from cpython.cobject */
+
+/* Module declarations from cpython.oldbuffer */
+
+/* Module declarations from cpython.set */
+
+/* Module declarations from cpython.buffer */
+
+/* Module declarations from cpython.bytes */
+
+/* Module declarations from cpython.pycapsule */
+
+/* Module declarations from cpython */
+
+/* Module declarations from TabProxies */
+
+static PyTypeObject *__pyx_ptype_10TabProxies_TupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_GTFProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_NamedTupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_BedProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_VCFProxy = 0;
+/* Module declarations from ctabix */
+
+static PyTypeObject *__pyx_ptype_6ctabix_Tabixfile = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_Parser = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_TabixIterator = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_TabixHeaderIterator = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_asTuple = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_asGTF = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_asBed = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_asVCF = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_TabixIteratorParsed = 0;
+#define __Pyx_MODULE_NAME "ctabix"
+int __pyx_module_is_main_ctabix = 0;
+
+/* Implementation of ctabix */
+static PyObject *__pyx_builtin_IOError;
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_OSError;
+static PyObject *__pyx_builtin_ord;
+static PyObject *__pyx_builtin_KeyError;
+static char __pyx_k_1[] = "invalid file opening mode `%s`";
+static char __pyx_k_2[] = ".tbi";
+static char __pyx_k_3[] = "file `%s` not found";
+static char __pyx_k_4[] = "index `%s` not found";
+static char __pyx_k_5[] = "could not open file `%s`";
+static char __pyx_k_6[] = "%s:%i-%i";
+static char __pyx_k_7[] = "invalid region `%s`";
+static char __pyx_k_8[] = "invalid region: start (%i) > end (%i)";
+static char __pyx_k_9[] = "start out of range (%i)";
+static char __pyx_k_10[] = "end out of range (%i)";
+static char __pyx_k_11[] = "I/O operation on closed file";
+static char __pyx_k_12[] = "malformatted query or wrong sequence name.\n";
+static char __pyx_k_13[] = "can't open header.\n";
+static char __pyx_k_15[] = "Filename '%s' already exists, use *force* to overwrite";
+static char __pyx_k_16[] = "could not open '%s' for writing";
+static char __pyx_k_17[] = "could not open '%s' for reading";
+static char __pyx_k_18[] = "writing failed";
+static char __pyx_k_20[] = "#";
+static char __pyx_k_22[] = "No such file '%s'";
+static char __pyx_k_23[] = ".gz";
+static char __pyx_k_24[] = "Filename '%s.tbi' already exists, use *force* to overwrite";
+static char __pyx_k_25[] = "unknown preset '%s', valid presets are '%s'";
+static char __pyx_k_26[] = ",";
+static char __pyx_k_27[] = "chromosome names";
+static char __pyx_k_28[] = "Tabixfile._isOpen (line 19)";
+static char __pyx_k_29[] = "Tabixfile._open (line 23)";
+static char __pyx_k_30[] = "Tabixfile._parseRegion (line 57)";
+static char __pyx_k_31[] = "Tabixfile.fetch (line 102)";
+static char __pyx_k_32[] = "Tabixfile.header.__get__ (line 140)";
+static char __pyx_k_33[] = "TabixIterator.__next__ (line 192)";
+static char __pyx_k_34[] = "TabixHeaderIterator.__next__ (line 239)";
+static char __pyx_k_35[] = "TabixIteratorParsed.__next__ (line 342)";
+static char __pyx_k_36[] = "tabix_compress (line 362)";
+static char __pyx_k_37[] = "tabix_index (line 407)";
+static char __pyx_k__r[] = "r";
+static char __pyx_k__w[] = "w";
+static char __pyx_k__bc[] = "bc";
+static char __pyx_k__ec[] = "ec";
+static char __pyx_k__fp[] = "fp";
+static char __pyx_k__os[] = "os";
+static char __pyx_k__sc[] = "sc";
+static char __pyx_k__bed[] = "bed";
+static char __pyx_k__end[] = "end";
+static char __pyx_k__gff[] = "gff";
+static char __pyx_k__idx[] = "idx";
+static char __pyx_k__len[] = "len";
+static char __pyx_k__ord[] = "ord";
+static char __pyx_k__sam[] = "sam";
+static char __pyx_k__sys[] = "sys";
+static char __pyx_k__tid[] = "tid";
+static char __pyx_k__vcf[] = "vcf";
+static char __pyx_k__copy[] = "copy";
+static char __pyx_k__gzip[] = "gzip";
+static char __pyx_k__join[] = "join";
+static char __pyx_k__keys[] = "keys";
+static char __pyx_k__mode[] = "mode";
+static char __pyx_k__path[] = "path";
+static char __pyx_k___open[] = "_open";
+static char __pyx_k__asBed[] = "asBed";
+static char __pyx_k__asGTF[] = "asGTF";
+static char __pyx_k__asVCF[] = "asVCF";
+static char __pyx_k__close[] = "close";
+static char __pyx_k__fetch[] = "fetch";
+static char __pyx_k__force[] = "force";
+static char __pyx_k__start[] = "start";
+static char __pyx_k__types[] = "types";
+static char __pyx_k__buffer[] = "buffer";
+static char __pyx_k__ctypes[] = "ctypes";
+static char __pyx_k__exists[] = "exists";
+static char __pyx_k__header[] = "header";
+static char __pyx_k__parser[] = "parser";
+static char __pyx_k__pileup[] = "pileup";
+static char __pyx_k__preset[] = "preset";
+static char __pyx_k__psltbl[] = "psltbl";
+static char __pyx_k__region[] = "region";
+static char __pyx_k__struct[] = "struct";
+static char __pyx_k__unlink[] = "unlink";
+static char __pyx_k__IOError[] = "IOError";
+static char __pyx_k__OSError[] = "OSError";
+static char __pyx_k____all__[] = "__all__";
+static char __pyx_k____get__[] = "__get__";
+static char __pyx_k___isOpen[] = "_isOpen";
+static char __pyx_k__asTuple[] = "asTuple";
+static char __pyx_k__end_col[] = "end_col";
+static char __pyx_k__seq_col[] = "seq_col";
+static char __pyx_k__KeyError[] = "KeyError";
+static char __pyx_k__O_RDONLY[] = "O_RDONLY";
+static char __pyx_k____main__[] = "__main__";
+static char __pyx_k____next__[] = "__next__";
+static char __pyx_k____test__[] = "__test__";
+static char __pyx_k__endswith[] = "endswith";
+static char __pyx_k__filename[] = "filename";
+static char __pyx_k__iterator[] = "iterator";
+static char __pyx_k__tempfile[] = "tempfile";
+static char __pyx_k__Tabixfile[] = "Tabixfile";
+static char __pyx_k__itertools[] = "itertools";
+static char __pyx_k__line_skip[] = "line_skip";
+static char __pyx_k__meta_char[] = "meta_char";
+static char __pyx_k__reference[] = "reference";
+static char __pyx_k__start_col[] = "start_col";
+static char __pyx_k__tabixfile[] = "tabixfile";
+static char __pyx_k__zerobased[] = "zerobased";
+static char __pyx_k__ValueError[] = "ValueError";
+static char __pyx_k__filename_in[] = "filename_in";
+static char __pyx_k__tabix_index[] = "tabix_index";
+static char __pyx_k___parseRegion[] = "_parseRegion";
+static char __pyx_k__filename_out[] = "filename_out";
+static char __pyx_k__StopIteration[] = "StopIteration";
+static char __pyx_k__TabixIterator[] = "TabixIterator";
+static char __pyx_k__tabix_compress[] = "tabix_compress";
+static char __pyx_k__TabixHeaderIterator[] = "TabixHeaderIterator";
+static char __pyx_k__TabixIteratorParsed[] = "TabixIteratorParsed";
+static PyObject *__pyx_kp_s_1;
+static PyObject *__pyx_kp_s_10;
+static PyObject *__pyx_kp_s_11;
+static PyObject *__pyx_kp_s_12;
+static PyObject *__pyx_kp_s_13;
+static PyObject *__pyx_kp_s_15;
+static PyObject *__pyx_kp_s_16;
+static PyObject *__pyx_kp_s_17;
+static PyObject *__pyx_kp_s_18;
+static PyObject *__pyx_kp_s_2;
+static PyObject *__pyx_kp_s_20;
+static PyObject *__pyx_kp_s_22;
+static PyObject *__pyx_kp_s_23;
+static PyObject *__pyx_kp_s_24;
+static PyObject *__pyx_kp_s_25;
+static PyObject *__pyx_kp_s_26;
+static PyObject *__pyx_kp_u_28;
+static PyObject *__pyx_kp_u_29;
+static PyObject *__pyx_kp_s_3;
+static PyObject *__pyx_kp_u_30;
+static PyObject *__pyx_kp_u_31;
+static PyObject *__pyx_kp_u_32;
+static PyObject *__pyx_kp_u_33;
+static PyObject *__pyx_kp_u_34;
+static PyObject *__pyx_kp_u_35;
+static PyObject *__pyx_kp_u_36;
+static PyObject *__pyx_kp_u_37;
+static PyObject *__pyx_kp_s_4;
+static PyObject *__pyx_kp_s_5;
+static PyObject *__pyx_kp_s_6;
+static PyObject *__pyx_kp_s_7;
+static PyObject *__pyx_kp_s_8;
+static PyObject *__pyx_kp_s_9;
+static PyObject *__pyx_n_s__IOError;
+static PyObject *__pyx_n_s__KeyError;
+static PyObject *__pyx_n_s__OSError;
+static PyObject *__pyx_n_s__O_RDONLY;
+static PyObject *__pyx_n_s__StopIteration;
+static PyObject *__pyx_n_s__TabixHeaderIterator;
+static PyObject *__pyx_n_s__TabixIterator;
+static PyObject *__pyx_n_s__TabixIteratorParsed;
+static PyObject *__pyx_n_s__Tabixfile;
+static PyObject *__pyx_n_s__ValueError;
+static PyObject *__pyx_n_s____all__;
+static PyObject *__pyx_n_s____get__;
+static PyObject *__pyx_n_s____main__;
+static PyObject *__pyx_n_s____next__;
+static PyObject *__pyx_n_s____test__;
+static PyObject *__pyx_n_s___isOpen;
+static PyObject *__pyx_n_s___open;
+static PyObject *__pyx_n_s___parseRegion;
+static PyObject *__pyx_n_s__asBed;
+static PyObject *__pyx_n_s__asGTF;
+static PyObject *__pyx_n_s__asTuple;
+static PyObject *__pyx_n_s__asVCF;
+static PyObject *__pyx_n_s__bc;
+static PyObject *__pyx_n_s__bed;
+static PyObject *__pyx_n_s__buffer;
+static PyObject *__pyx_n_s__close;
+static PyObject *__pyx_n_s__copy;
+static PyObject *__pyx_n_s__ctypes;
+static PyObject *__pyx_n_s__ec;
+static PyObject *__pyx_n_s__end;
+static PyObject *__pyx_n_s__end_col;
+static PyObject *__pyx_n_s__endswith;
+static PyObject *__pyx_n_s__exists;
+static PyObject *__pyx_n_s__fetch;
+static PyObject *__pyx_n_s__filename;
+static PyObject *__pyx_n_s__filename_in;
+static PyObject *__pyx_n_s__filename_out;
+static PyObject *__pyx_n_s__force;
+static PyObject *__pyx_n_s__fp;
+static PyObject *__pyx_n_s__gff;
+static PyObject *__pyx_n_s__gzip;
+static PyObject *__pyx_n_s__header;
+static PyObject *__pyx_n_s__idx;
+static PyObject *__pyx_n_s__iterator;
+static PyObject *__pyx_n_s__itertools;
+static PyObject *__pyx_n_s__join;
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+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_Parser = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_Parser = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_Parser = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_Parser = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.Parser"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_Parser), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_Parser, /*tp_as_number*/
+ &__pyx_tp_as_sequence_Parser, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_Parser, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_Parser, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ 0, /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_6ctabix_Parser, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_Parser, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_TabixIterator(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ if (__pyx_pf_6ctabix_13TabixIterator___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_6ctabix_TabixIterator(PyObject *o) {
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_6ctabix_13TabixIterator___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static PyMethodDef __pyx_methods_6ctabix_TabixIterator[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_6ctabix_13TabixIterator___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_6ctabix_13TabixIterator___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_TabixIterator = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_TabixIterator = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_TabixIterator = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_TabixIterator = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_TabixIterator = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.TabixIterator"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_TabixIterator), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_TabixIterator, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_TabixIterator, /*tp_as_number*/
+ &__pyx_tp_as_sequence_TabixIterator, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_TabixIterator, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_TabixIterator, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("iterates over rows in *tabixfile* in region\n given by *tid*, *start* and *end*.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_6ctabix_13TabixIterator___iter__, /*tp_iter*/
+ __pyx_pf_6ctabix_13TabixIterator___next__, /*tp_iternext*/
+ __pyx_methods_6ctabix_TabixIterator, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_TabixIterator, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_TabixHeaderIterator(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ if (__pyx_pf_6ctabix_19TabixHeaderIterator___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_6ctabix_TabixHeaderIterator(PyObject *o) {
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_6ctabix_19TabixHeaderIterator___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static PyMethodDef __pyx_methods_6ctabix_TabixHeaderIterator[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_6ctabix_19TabixHeaderIterator___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_6ctabix_19TabixHeaderIterator___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_TabixHeaderIterator = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_TabixHeaderIterator = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_TabixHeaderIterator = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_TabixHeaderIterator = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_TabixHeaderIterator = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.TabixHeaderIterator"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_TabixHeaderIterator), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_TabixHeaderIterator, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_TabixHeaderIterator, /*tp_as_number*/
+ &__pyx_tp_as_sequence_TabixHeaderIterator, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_TabixHeaderIterator, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_TabixHeaderIterator, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("return header lines.\n "), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ __pyx_pf_6ctabix_19TabixHeaderIterator___iter__, /*tp_iter*/
+ __pyx_pf_6ctabix_19TabixHeaderIterator___next__, /*tp_iternext*/
+ __pyx_methods_6ctabix_TabixHeaderIterator, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_TabixHeaderIterator, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_asTuple(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
+ if (!o) return 0;
+ return o;
+}
+
+static PyMethodDef __pyx_methods_6ctabix_asTuple[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asTuple = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asTuple = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asTuple = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asTuple = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_asTuple = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.asTuple"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_asTuple), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_asTuple, /*tp_as_number*/
+ &__pyx_tp_as_sequence_asTuple, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_asTuple, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ __pyx_pf_6ctabix_7asTuple___call__, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_asTuple, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("converts a :term:`tabix row` into a python tuple."), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_6ctabix_asTuple, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_asTuple, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_asGTF(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
+ if (!o) return 0;
+ return o;
+}
+
+static PyMethodDef __pyx_methods_6ctabix_asGTF[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asGTF = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
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+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asGTF = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asGTF = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asGTF = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_asGTF = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.asGTF"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_asGTF), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_asGTF, /*tp_as_number*/
+ &__pyx_tp_as_sequence_asGTF, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_asGTF, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ __pyx_pf_6ctabix_5asGTF___call__, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_asGTF, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("converts a :term:`tabix row` into a GTF record."), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_6ctabix_asGTF, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_asGTF, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_asBed(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
+ if (!o) return 0;
+ return o;
+}
+
+static PyMethodDef __pyx_methods_6ctabix_asBed[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asBed = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asBed = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asBed = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asBed = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_asBed = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.asBed"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_asBed), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_asBed, /*tp_as_number*/
+ &__pyx_tp_as_sequence_asBed, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_asBed, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ __pyx_pf_6ctabix_5asBed___call__, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_asBed, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("converts a :term:`tabix row` into a GTF record."), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_6ctabix_asBed, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_asBed, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_asVCF(PyTypeObject *t, PyObject *a, PyObject *k) {
+ PyObject *o = __pyx_tp_new_6ctabix_Parser(t, a, k);
+ if (!o) return 0;
+ return o;
+}
+
+static PyMethodDef __pyx_methods_6ctabix_asVCF[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asVCF = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asVCF = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asVCF = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asVCF = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_asVCF = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.asVCF"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_asVCF), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_Parser, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_asVCF, /*tp_as_number*/
+ &__pyx_tp_as_sequence_asVCF, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_asVCF, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ __pyx_pf_6ctabix_5asVCF___call__, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_asVCF, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER, /*tp_flags*/
+ __Pyx_DOCSTR("converts a :term:`tabix row` into a VCF record."), /*tp_doc*/
+ 0, /*tp_traverse*/
+ 0, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_6ctabix_asVCF, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ 0, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_6ctabix_asVCF, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_6ctabix_TabixIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_6ctabix_TabixIteratorParsed *p;
+ PyObject *o = (*t->tp_alloc)(t, 0);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_6ctabix_TabixIteratorParsed *)o);
+ p->parser = ((struct __pyx_obj_6ctabix_Parser *)Py_None); Py_INCREF(Py_None);
+ if (__pyx_pf_6ctabix_19TabixIteratorParsed___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_6ctabix_TabixIteratorParsed(PyObject *o) {
+ struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
+ {
+ PyObject *etype, *eval, *etb;
+ PyErr_Fetch(&etype, &eval, &etb);
+ ++Py_REFCNT(o);
+ __pyx_pf_6ctabix_19TabixIteratorParsed___dealloc__(o);
+ if (PyErr_Occurred()) PyErr_WriteUnraisable(o);
+ --Py_REFCNT(o);
+ PyErr_Restore(etype, eval, etb);
+ }
+ Py_XDECREF(((PyObject *)p->parser));
+ (*Py_TYPE(o)->tp_free)(o);
+}
+
+static int __pyx_tp_traverse_6ctabix_TabixIteratorParsed(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
+ if (p->parser) {
+ e = (*v)(((PyObject*)p->parser), a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_6ctabix_TabixIteratorParsed(PyObject *o) {
+ struct __pyx_obj_6ctabix_TabixIteratorParsed *p = (struct __pyx_obj_6ctabix_TabixIteratorParsed *)o;
+ PyObject* tmp;
+ tmp = ((PyObject*)p->parser);
+ p->parser = ((struct __pyx_obj_6ctabix_Parser *)Py_None); Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyMethodDef __pyx_methods_6ctabix_TabixIteratorParsed[] = {
+ {__Pyx_NAMESTR("__next__"), (PyCFunction)__pyx_pf_6ctabix_19TabixIteratorParsed___next__, METH_NOARGS|METH_COEXIST, __Pyx_DOCSTR(__pyx_doc_6ctabix_19TabixIteratorParsed___next__)},
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_TabixIteratorParsed = {
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+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_TabixIteratorParsed = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_TabixIteratorParsed = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_TabixIteratorParsed = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_6ctabix_TabixIteratorParsed = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("ctabix.TabixIteratorParsed"), /*tp_name*/
+ sizeof(struct __pyx_obj_6ctabix_TabixIteratorParsed), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_6ctabix_TabixIteratorParsed, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_TabixIteratorParsed, /*tp_as_number*/
+ &__pyx_tp_as_sequence_TabixIteratorParsed, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_TabixIteratorParsed, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
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+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
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+}
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+}
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+ #if PY_MAJOR_VERSION < 3
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+ "%s() keywords must be strings", function_name);
+ return 0;
+invalid_keyword:
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION < 3
+ "%s() got an unexpected keyword argument '%s'",
+ function_name, PyString_AsString(key));
+ #else
+ "%s() got an unexpected keyword argument '%U'",
+ function_name, key);
+ #endif
+ return 0;
+}
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+ const char* func_name,
+ PyObject* kw_name)
+{
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION >= 3
+ "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
+ #else
+ "%s() got multiple values for keyword argument '%s'", func_name,
+ PyString_AS_STRING(kw_name));
+ #endif
+}
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+ int exact,
+ Py_ssize_t num_min,
+ Py_ssize_t num_max,
+ Py_ssize_t num_found)
+{
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+}
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+ const char* function_name)
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+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
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+ } else {
+ goto invalid_keyword;
+ }
+ }
+ }
+ }
+ }
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+arg_passed_twice:
+ __Pyx_RaiseDoubleKeywordsError(function_name, **name);
+ goto bad;
+invalid_keyword_type:
+ PyErr_Format(PyExc_TypeError,
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+ goto bad;
+invalid_keyword:
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION < 3
+ "%s() got an unexpected keyword argument '%s'",
+ function_name, PyString_AsString(key));
+ #else
+ "%s() got an unexpected keyword argument '%U'",
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+ #endif
+bad:
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+}
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+ "need more than %d value%s to unpack", (int)index,
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+ "need more than %zd value%s to unpack", index,
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+}
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+ "too many values to unpack (expected %zd)", expected);
+ #endif
+}
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+ if (!(item = PyIter_Next(iter))) {
+ if (!PyErr_Occurred()) {
+ __Pyx_RaiseNeedMoreValuesError(index);
+ }
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+}
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+}
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+{
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+ }
+ else {
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+ PyErr_Format(PyExc_TypeError,
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+ return 0;
+}
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+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
+ PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
+}
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+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
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+ local_value = tstate->curexc_value;
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+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+ PyErr_NormalizeException(&local_type, &local_value, &local_tb);
+ if (unlikely(tstate->curexc_type))
+ goto bad;
+ #if PY_MAJOR_VERSION >= 3
+ if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
+ goto bad;
+ #endif
+ *type = local_type;
+ *value = local_value;
+ *tb = local_tb;
+ Py_INCREF(local_type);
+ Py_INCREF(local_value);
+ Py_INCREF(local_tb);
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = local_type;
+ tstate->exc_value = local_value;
+ tstate->exc_traceback = local_tb;
+ /* Make sure tstate is in a consistent state when we XDECREF
+ these objects (XDECREF may run arbitrary code). */
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+ return 0;
+bad:
+ *type = 0;
+ *value = 0;
+ *tb = 0;
+ Py_XDECREF(local_type);
+ Py_XDECREF(local_value);
+ Py_XDECREF(local_tb);
+ return -1;
+}
+
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->exc_type;
+ *value = tstate->exc_value;
+ *tb = tstate->exc_traceback;
+ Py_XINCREF(*type);
+ Py_XINCREF(*value);
+ Py_XINCREF(*tb);
+}
+
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = type;
+ tstate->exc_value = value;
+ tstate->exc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
+ PyObject *py_import = 0;
+ PyObject *empty_list = 0;
+ PyObject *module = 0;
+ PyObject *global_dict = 0;
+ PyObject *empty_dict = 0;
+ PyObject *list;
+ py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
+ if (!py_import)
+ goto bad;
+ if (from_list)
+ list = from_list;
+ else {
+ empty_list = PyList_New(0);
+ if (!empty_list)
+ goto bad;
+ list = empty_list;
+ }
+ global_dict = PyModule_GetDict(__pyx_m);
+ if (!global_dict)
+ goto bad;
+ empty_dict = PyDict_New();
+ if (!empty_dict)
+ goto bad;
+ module = PyObject_CallFunctionObjArgs(py_import,
+ name, global_dict, empty_dict, list, NULL);
+bad:
+ Py_XDECREF(empty_list);
+ Py_XDECREF(py_import);
+ Py_XDECREF(empty_dict);
+ return module;
+}
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+
+ tmp_type = tstate->curexc_type;
+ tmp_value = tstate->curexc_value;
+ tmp_tb = tstate->curexc_traceback;
+ tstate->curexc_type = type;
+ tstate->curexc_value = value;
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->curexc_type;
+ *value = tstate->curexc_value;
+ *tb = tstate->curexc_traceback;
+
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+}
+
+
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ Py_XINCREF(type);
+ Py_XINCREF(value);
+ Py_XINCREF(tb);
+ /* First, check the traceback argument, replacing None with NULL. */
+ if (tb == Py_None) {
+ Py_DECREF(tb);
+ tb = 0;
+ }
+ else if (tb != NULL && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto raise_error;
+ }
+ /* Next, replace a missing value with None */
+ if (value == NULL) {
+ value = Py_None;
+ Py_INCREF(value);
+ }
+ #if PY_VERSION_HEX < 0x02050000
+ if (!PyClass_Check(type))
+ #else
+ if (!PyType_Check(type))
+ #endif
+ {
+ /* Raising an instance. The value should be a dummy. */
+ if (value != Py_None) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto raise_error;
+ }
+ /* Normalize to raise <class>, <instance> */
+ Py_DECREF(value);
+ value = type;
+ #if PY_VERSION_HEX < 0x02050000
+ if (PyInstance_Check(type)) {
+ type = (PyObject*) ((PyInstanceObject*)type)->in_class;
+ Py_INCREF(type);
+ }
+ else {
+ type = 0;
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception must be an old-style class or instance");
+ goto raise_error;
+ }
+ #else
+ type = (PyObject*) Py_TYPE(type);
+ Py_INCREF(type);
+ if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto raise_error;
+ }
+ #endif
+ }
+
+ __Pyx_ErrRestore(type, value, tb);
+ return;
+raise_error:
+ Py_XDECREF(value);
+ Py_XDECREF(type);
+ Py_XDECREF(tb);
+ return;
+}
+
+#else /* Python 3+ */
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ if (tb == Py_None) {
+ tb = 0;
+ } else if (tb && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto bad;
+ }
+ if (value == Py_None)
+ value = 0;
+
+ if (PyExceptionInstance_Check(type)) {
+ if (value) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto bad;
+ }
+ value = type;
+ type = (PyObject*) Py_TYPE(value);
+ } else if (!PyExceptionClass_Check(type)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto bad;
+ }
+
+ PyErr_SetObject(type, value);
+
+ if (tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ PyObject* tmp_tb = tstate->curexc_traceback;
+ if (tb != tmp_tb) {
+ Py_INCREF(tb);
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_tb);
+ }
+ }
+
+bad:
+ return;
+}
+#endif
+
+static CYTHON_INLINE int32_t __Pyx_PyInt_from_py_int32_t(PyObject* x) {
+ const int32_t neg_one = (int32_t)-1, const_zero = (int32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if (sizeof(int32_t) == sizeof(char)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedChar(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedChar(x);
+ } else if (sizeof(int32_t) == sizeof(short)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedShort(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedShort(x);
+ } else if (sizeof(int32_t) == sizeof(int)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedInt(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedInt(x);
+ } else if (sizeof(int32_t) == sizeof(long)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedLong(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedLong(x);
+ } else if (sizeof(int32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return (int32_t)__Pyx_PyInt_AsUnsignedLongLong(x);
+ else
+ return (int32_t)__Pyx_PyInt_AsSignedLongLong(x);
+ } else {
+ int32_t val;
+ PyObject *v = __Pyx_PyNumber_Int(x);
+ #if PY_VERSION_HEX < 0x03000000
+ if (likely(v) && !PyLong_Check(v)) {
+ PyObject *tmp = v;
+ v = PyNumber_Long(tmp);
+ Py_DECREF(tmp);
+ }
+ #endif
+ if (likely(v)) {
+ int one = 1; int is_little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ int ret = _PyLong_AsByteArray((PyLongObject *)v,
+ bytes, sizeof(val),
+ is_little, !is_unsigned);
+ Py_DECREF(v);
+ if (likely(!ret))
+ return val;
+ }
+ return (int32_t)-1;
+ }
+}
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
+ const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned char" :
+ "value too large to convert to unsigned char");
+ }
+ return (unsigned char)-1;
+ }
+ return (unsigned char)val;
+ }
+ return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
+ const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned short" :
+ "value too large to convert to unsigned short");
+ }
+ return (unsigned short)-1;
+ }
+ return (unsigned short)val;
+ }
+ return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
+ const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned int" :
+ "value too large to convert to unsigned int");
+ }
+ return (unsigned int)-1;
+ }
+ return (unsigned int)val;
+ }
+ return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
+ const char neg_one = (char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to char" :
+ "value too large to convert to char");
+ }
+ return (char)-1;
+ }
+ return (char)val;
+ }
+ return (char)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
+ const short neg_one = (short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to short" :
+ "value too large to convert to short");
+ }
+ return (short)-1;
+ }
+ return (short)val;
+ }
+ return (short)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
+ const signed char neg_one = (signed char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed char" :
+ "value too large to convert to signed char");
+ }
+ return (signed char)-1;
+ }
+ return (signed char)val;
+ }
+ return (signed char)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
+ const signed short neg_one = (signed short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed short" :
+ "value too large to convert to signed short");
+ }
+ return (signed short)-1;
+ }
+ return (signed short)val;
+ }
+ return (signed short)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
+ const signed int neg_one = (signed int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed int" :
+ "value too large to convert to signed int");
+ }
+ return (signed int)-1;
+ }
+ return (signed int)val;
+ }
+ return (signed int)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
+ const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return (unsigned long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ unsigned long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned long)-1;
+ val = __Pyx_PyInt_AsUnsignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
+ const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return (unsigned PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ unsigned PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
+ const long neg_one = (long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return (long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (long)-1;
+ val = __Pyx_PyInt_AsLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
+ const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return (PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
+ const signed long neg_one = (signed long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return (signed long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ signed long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed long)-1;
+ val = __Pyx_PyInt_AsSignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
+ const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return (signed PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ signed PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsSignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+#ifndef __PYX_HAVE_RT_ImportType
+#define __PYX_HAVE_RT_ImportType
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
+ long size, int strict)
+{
+ PyObject *py_module = 0;
+ PyObject *result = 0;
+ PyObject *py_name = 0;
+ char warning[200];
+
+ py_module = __Pyx_ImportModule(module_name);
+ if (!py_module)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(class_name);
+ #else
+ py_name = PyUnicode_FromString(class_name);
+ #endif
+ if (!py_name)
+ goto bad;
+ result = PyObject_GetAttr(py_module, py_name);
+ Py_DECREF(py_name);
+ py_name = 0;
+ Py_DECREF(py_module);
+ py_module = 0;
+ if (!result)
+ goto bad;
+ if (!PyType_Check(result)) {
+ PyErr_Format(PyExc_TypeError,
+ "%s.%s is not a type object",
+ module_name, class_name);
+ goto bad;
+ }
+ if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
+ PyOS_snprintf(warning, sizeof(warning),
+ "%s.%s size changed, may indicate binary incompatibility",
+ module_name, class_name);
+ #if PY_VERSION_HEX < 0x02050000
+ PyErr_Warn(NULL, warning);
+ #else
+ PyErr_WarnEx(NULL, warning, 0);
+ #endif
+ }
+ else if (((PyTypeObject *)result)->tp_basicsize != size) {
+ PyErr_Format(PyExc_ValueError,
+ "%s.%s has the wrong size, try recompiling",
+ module_name, class_name);
+ goto bad;
+ }
+ return (PyTypeObject *)result;
+bad:
+ Py_XDECREF(py_module);
+ Py_XDECREF(result);
+ return 0;
+}
+#endif
+
+#ifndef __PYX_HAVE_RT_ImportModule
+#define __PYX_HAVE_RT_ImportModule
+static PyObject *__Pyx_ImportModule(const char *name) {
+ PyObject *py_name = 0;
+ PyObject *py_module = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(name);
+ #else
+ py_name = PyUnicode_FromString(name);
+ #endif
+ if (!py_name)
+ goto bad;
+ py_module = PyImport_Import(py_name);
+ Py_DECREF(py_name);
+ return py_module;
+bad:
+ Py_XDECREF(py_name);
+ return 0;
+}
+#endif
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr) {
+ PyObject *ob = PyMapping_GetItemString(dict, (char *)"__pyx_vtable__");
+ if (!ob)
+ goto bad;
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+ *(void **)vtabptr = PyCapsule_GetPointer(ob, 0);
+#else
+ *(void **)vtabptr = PyCObject_AsVoidPtr(ob);
+#endif
+ if (!*(void **)vtabptr)
+ goto bad;
+ Py_DECREF(ob);
+ return 0;
+bad:
+ Py_XDECREF(ob);
+ return -1;
+}
+
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+
+static void __Pyx_AddTraceback(const char *funcname) {
+ PyObject *py_srcfile = 0;
+ PyObject *py_funcname = 0;
+ PyObject *py_globals = 0;
+ PyCodeObject *py_code = 0;
+ PyFrameObject *py_frame = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_srcfile = PyString_FromString(__pyx_filename);
+ #else
+ py_srcfile = PyUnicode_FromString(__pyx_filename);
+ #endif
+ if (!py_srcfile) goto bad;
+ if (__pyx_clineno) {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #else
+ py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #endif
+ }
+ else {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromString(funcname);
+ #else
+ py_funcname = PyUnicode_FromString(funcname);
+ #endif
+ }
+ if (!py_funcname) goto bad;
+ py_globals = PyModule_GetDict(__pyx_m);
+ if (!py_globals) goto bad;
+ py_code = PyCode_New(
+ 0, /*int argcount,*/
+ #if PY_MAJOR_VERSION >= 3
+ 0, /*int kwonlyargcount,*/
+ #endif
+ 0, /*int nlocals,*/
+ 0, /*int stacksize,*/
+ 0, /*int flags,*/
+ __pyx_empty_bytes, /*PyObject *code,*/
+ __pyx_empty_tuple, /*PyObject *consts,*/
+ __pyx_empty_tuple, /*PyObject *names,*/
+ __pyx_empty_tuple, /*PyObject *varnames,*/
+ __pyx_empty_tuple, /*PyObject *freevars,*/
+ __pyx_empty_tuple, /*PyObject *cellvars,*/
+ py_srcfile, /*PyObject *filename,*/
+ py_funcname, /*PyObject *name,*/
+ __pyx_lineno, /*int firstlineno,*/
+ __pyx_empty_bytes /*PyObject *lnotab*/
+ );
+ if (!py_code) goto bad;
+ py_frame = PyFrame_New(
+ PyThreadState_GET(), /*PyThreadState *tstate,*/
+ py_code, /*PyCodeObject *code,*/
+ py_globals, /*PyObject *globals,*/
+ 0 /*PyObject *locals*/
+ );
+ if (!py_frame) goto bad;
+ py_frame->f_lineno = __pyx_lineno;
+ PyTraceBack_Here(py_frame);
+bad:
+ Py_XDECREF(py_srcfile);
+ Py_XDECREF(py_funcname);
+ Py_XDECREF(py_code);
+ Py_XDECREF(py_frame);
+}
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+ while (t->p) {
+ #if PY_MAJOR_VERSION < 3
+ if (t->is_unicode) {
+ *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+ } else if (t->intern) {
+ *t->p = PyString_InternFromString(t->s);
+ } else {
+ *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+ }
+ #else /* Python 3+ has unicode identifiers */
+ if (t->is_unicode | t->is_str) {
+ if (t->intern) {
+ *t->p = PyUnicode_InternFromString(t->s);
+ } else if (t->encoding) {
+ *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
+ } else {
+ *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
+ }
+ } else {
+ *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
+ }
+ #endif
+ if (!*t->p)
+ return -1;
+ ++t;
+ }
+ return 0;
+}
+
+/* Type Conversion Functions */
+
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+ int is_true = x == Py_True;
+ if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+ else return PyObject_IsTrue(x);
+}
+
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
+ PyNumberMethods *m;
+ const char *name = NULL;
+ PyObject *res = NULL;
+#if PY_VERSION_HEX < 0x03000000
+ if (PyInt_Check(x) || PyLong_Check(x))
+#else
+ if (PyLong_Check(x))
+#endif
+ return Py_INCREF(x), x;
+ m = Py_TYPE(x)->tp_as_number;
+#if PY_VERSION_HEX < 0x03000000
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Int(x);
+ }
+ else if (m && m->nb_long) {
+ name = "long";
+ res = PyNumber_Long(x);
+ }
+#else
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Long(x);
+ }
+#endif
+ if (res) {
+#if PY_VERSION_HEX < 0x03000000
+ if (!PyInt_Check(res) && !PyLong_Check(res)) {
+#else
+ if (!PyLong_Check(res)) {
+#endif
+ PyErr_Format(PyExc_TypeError,
+ "__%s__ returned non-%s (type %.200s)",
+ name, name, Py_TYPE(res)->tp_name);
+ Py_DECREF(res);
+ return NULL;
+ }
+ }
+ else if (!PyErr_Occurred()) {
+ PyErr_SetString(PyExc_TypeError,
+ "an integer is required");
+ }
+ return res;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+ Py_ssize_t ival;
+ PyObject* x = PyNumber_Index(b);
+ if (!x) return -1;
+ ival = PyInt_AsSsize_t(x);
+ Py_DECREF(x);
+ return ival;
+}
+
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+#if PY_VERSION_HEX < 0x02050000
+ if (ival <= LONG_MAX)
+ return PyInt_FromLong((long)ival);
+ else {
+ unsigned char *bytes = (unsigned char *) &ival;
+ int one = 1; int little = (int)*(unsigned char*)&one;
+ return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
+ }
+#else
+ return PyInt_FromSize_t(ival);
+#endif
+}
+
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
+ unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
+ if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
+ return (size_t)-1;
+ } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "value too large to convert to size_t");
+ return (size_t)-1;
+ }
+ return (size_t)val;
+}
+
+
+#endif /* Py_PYTHON_H */
# tabix support
cdef extern from "tabix.h":
- ctypedef struct ti_index_t:
- pass
+ ctypedef struct ti_conf_t:
+ int32_t preset
+ int32_t sc, bc, ec
+ int32_t meta_char, line_skip
+ ctypedef struct ti_index_t:
+ pass
+
ctypedef struct tabix_t:
BGZF *fp
ti_index_t *idx
ctypedef struct ti_iter_t:
pass
- ctypedef struct ti_conf_t:
- int32_t preset
- int32_t sc, bc, ec
- int32_t meta_char, line_skip
-
tabix_t *ti_open(char *fn, char *fnidx)
int ti_lazy_index_load(tabix_t *t)
# pointer should be freed by a single free() call by the routine
# calling this function. The number of sequences is returned at *n
char **ti_seqname(ti_index_t *idx, int *n)
-
# Destroy the iterator
void ti_iter_destroy(ti_iter_t iter)
# /* Get the data line pointed by the iterator and iterate to the next record. */
# char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
+
+cdef class Tabixfile:
+ cdef char * filename
+
+ # pointer to tabixfile
+ cdef tabix_t * tabixfile
+
+cdef class Parser:
+ pass
# cython: embedsignature=True
# adds doc-strings for sphinx
-import tempfile, os, sys, types, itertools, struct, ctypes
+import tempfile, os, sys, types, itertools, struct, ctypes, gzip
+from cpython cimport PyString_FromStringAndSize, PyString_AS_STRING
+cimport TabProxies
cdef class Tabixfile:
'''*(filename, mode='r')*
index (*filename* + ".tbi") will raise an exception.
'''
- cdef char * filename
-
- # pointer to tabixfile
- cdef tabix_t * tabixfile
-
def __cinit__(self, *args, **kwargs ):
self.tabixfile = NULL
self._open( *args, **kwargs )
else:
return TabixIteratorParsed( self, -1, 0, 0, parser )
+ property header:
+ def __get__( self ):
+ '''return header lines as an iterator.
+
+ Note that the header lines do not contain the newline '\n' character.
+ '''
+ return TabixHeaderIterator( self )
+
property contigs:
- '''chromosome names'''
- def __get__(self):
- cdef char ** sequences
- cdef int nsequences
+ '''chromosome names'''
+ def __get__(self):
+ cdef char ** sequences
+ cdef int nsequences
- ti_lazy_index_load( self.tabixfile )
- sequences = ti_seqname( self.tabixfile.idx, &nsequences )
- cdef int x
- result = []
- for x from 0 <= x < nsequences:
- result.append( sequences[x] )
- return result
+ ti_lazy_index_load( self.tabixfile )
+ sequences = ti_seqname( self.tabixfile.idx, &nsequences )
+ cdef int x
+ result = []
+ for x from 0 <= x < nsequences:
+ result.append( sequences[x] )
+ return result
cdef class TabixIterator:
"""iterates over rows in *tabixfile* in region
cdef char * s
cdef int len
- s = ti_read(self.tabixfile, self.iterator, &len)
- if s == NULL: raise StopIteration
+ # metachar filtering does not work within tabix
+ # though it should. Getting the metachar is a pain
+ # as ti_index_t is incomplete type.
+
+ # simply use '#' for now.
+ while 1:
+ s = ti_read(self.tabixfile, self.iterator, &len)
+ if s == NULL: raise StopIteration
+ if s[0] != '#': break
+
return s
def __dealloc__(self):
if <void*>self.iterator != NULL:
ti_iter_destroy(self.iterator)
-def toDot( v ):
- '''convert value to '.' if None'''
- if v == None: return "."
- else: return str(v)
-
-def quote( v ):
- '''return a quoted attribute.'''
- if type(v) in types.StringTypes:
- return '"%s"' % v
- else:
- return str(v)
-
-cdef class TupleProxy:
- '''Proxy class for access to parsed row as a tuple.
-
- This class represents a table row for fast read-access.
- '''
-
- cdef:
- char * data
- char ** fields
- int nfields
- int index
-
- def __cinit__(self ):
-
- self.data = NULL
- self.fields = NULL
- self.index = 0
-
- cdef take( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
-
- Take ownership of the pointer.
- '''
- self.data = buffer
- self.update( buffer, nbytes )
-
- cdef present( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
-
- Do not take ownership of the pointer.
- '''
- self.update( buffer, nbytes )
-
- cdef copy( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
+cdef class TabixHeaderIterator:
+ """return header lines.
+ """
+
+ cdef ti_iter_t iterator
+ cdef tabix_t * tabixfile
- Take a copy of buffer.
- '''
- cdef int s
- # +1 for '\0'
- s = sizeof(char) * (nbytes + 1)
- self.data = <char*>malloc( s )
- memcpy( <char*>self.data, buffer, s )
- self.update( self.data, nbytes )
-
- cdef update( self, char * buffer, size_t nbytes ):
- '''update internal data.'''
- cdef char * pos
- cdef char * old_pos
- cdef int field
- cdef int max_fields
- field = 0
-
- if buffer[nbytes] != 0:
- raise ValueError( "incomplete line at %s" % buffer )
+ def __cinit__(self, Tabixfile tabixfile ):
- if self.fields != NULL:
- free(self.fields)
-
- max_fields = nbytes / 4
- self.fields = <char **>calloc( max_fields, sizeof(char *) )
-
- pos = buffer
- self.fields[0] = pos
- field += 1
- old_pos = pos
+ assert tabixfile._isOpen()
- while 1:
-
- pos = <char*>memchr( pos, '\t', nbytes )
- if pos == NULL: break
- pos[0] = '\0'
- pos += 1
- self.fields[field] = pos
- field += 1
- if field >= max_fields:
- raise ValueError("row too large - more than %i fields" % max_fields )
- nbytes -= pos - old_pos
- if nbytes < 0: break
- old_pos = pos
-
- self.nfields = field
-
- def __getitem__( self, key ):
-
- cdef int i
- i = key
- if i < 0: i += self.nfields
- if i >= self.nfields or i < 0:
- raise IndexError( "list index out of range" )
- return self.fields[i]
+ # makes sure that samfile stays alive as long as the
+ # iterator is alive.
+ self.tabixfile = tabixfile.tabixfile
- def __len__(self):
- return self.nfields
+ self.iterator = ti_query(self.tabixfile, NULL, 0, 0)
- def __dealloc__(self):
- if self.data != NULL:
- free(self.data)
+ if <void*>self.iterator == NULL:
+ raise ValueError("can't open header.\n")
def __iter__(self):
- self.index = 0
- return self
+ return self
def __next__(self):
"""python version of next().
- """
- if self.index >= self.nfields:
- raise StopIteration
- self.index += 1
- return self.fields[self.index-1]
-cdef class GTFProxy:
- '''Proxy class for access to GTF fields.
-
- This class represents a GTF entry for fast read-access.
- Write-access has been added as well, though some care must
- be taken. If any of the string fields (contig, source, ...)
- are set, the new value is tied to the lifetime of the
- argument that was supplied.
-
- The only exception is the attributes field when set from
- a dictionary - this field will manage its own memory.
-
- '''
-
- cdef:
- char * contig
- char * source
- char * feature
- uint32_t start
- uint32_t end
- char * score
- char * strand
- char * frame
- char * attributes
- int nbytes
- char * data
- cdef bint isModified
- cdef bint hasOwnAttributes
-
- def __cinit__(self ):
- self.data = NULL
- self.isModified = False
- self.hasOwnAttributes = False
-
- cdef take( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
-
- Take ownership of the pointer.
- '''
- self.data = buffer
- self.update( buffer, nbytes )
- self.isModified = False
-
- cdef present( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
-
- Do not take ownership of the pointer.
- '''
- self.update( buffer, nbytes )
- self.isModified = False
-
- cdef copy( self, char * buffer, size_t nbytes ):
- '''start presenting buffer.
-
- Take a copy of buffer.
- '''
- cdef int s
- # +1 for '\0'
- s = sizeof(char) * (nbytes + 1)
- self.data = <char*>malloc( s )
- memcpy( <char*>self.data, buffer, s )
- self.update( self.data, nbytes )
- self.isModified = False
-
- cdef update( self, char * buffer, size_t nbytes ):
- '''update internal data.
-
- nbytes does not include the terminal '\0'.
- '''
- cdef int end
- cdef char * cstart, * cend, * cscore
- self.contig = buffer
- self.nbytes = nbytes
- cdef char * pos
-
- if buffer[nbytes] != 0:
- raise ValueError( "incomplete line at %s" % buffer )
-
- pos = strchr( buffer, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.source = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.feature = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- cstart = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- cend = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.score = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.strand = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.frame = pos
-
- pos = strchr( pos, '\t' )
- if pos == NULL: raise ValueError( "malformatted entry at %s" % buffer )
- pos[0] = '\0'
- pos += 1
- self.attributes = pos
- self.start = atoi( cstart ) - 1
- self.end = atoi( cend )
-
- property contig:
- '''contig of feature.'''
- def __get__( self ): return self.contig
- def __set__( self, value ):
- self.isModified = True
- self.contig = value
-
- property feature:
- '''feature name.'''
- def __get__( self ): return self.feature
- def __set__( self, value ):
- self.isModified = True
- self.feature = value
-
- property source:
- '''feature source.'''
- def __get__( self ): return self.source
- def __set__( self, value ):
- self.isModified = True
- self.source = value
-
- property start:
- '''feature start (in 0-based open/closed coordinates).'''
- def __get__( self ): return self.start
- def __set__( self, value ):
- self.isModified = True
- self.start = value
-
- property end:
- '''feature end (in 0-based open/closed coordinates).'''
- def __get__( self ): return self.end
- def __set__( self, value ):
- self.isModified = True
- self.end = value
-
- property score:
- '''feature score.'''
- def __get__( self ):
- if self.score[0] == '.' and self.score[1] == '\0' :
- return None
- else:
- return atof(self.score)
- def __set__( self, value ):
- self.isModified = True
- self.score = value
-
- property strand:
- '''feature strand.'''
- def __get__( self ): return self.strand
- def __set__( self, value ):
- self.isModified = True
- self.strand = value
-
- property frame:
- '''feature frame.'''
- def __get__( self ): return self.frame
- def __set__( self, value ):
- self.isModified = True
- self.frame = value
-
- property attributes:
- '''feature attributes (as a string).'''
- def __get__( self ): return self.attributes
- def __set__( self, value ):
- self.isModified = True
- self.attributes = value
-
- def asDict( self ):
- """parse attributes - return as dict
+ pyrex uses this non-standard name instead of next()
"""
-
- # remove comments
- attributes = self.attributes
-
- # separate into fields
- fields = [ x.strip() for x in attributes.split(";")[:-1]]
-
- result = {}
-
- for f in fields:
-
- d = [ x.strip() for x in f.split(" ")]
-
- n,v = d[0], d[1]
- if len(d) > 2: v = d[1:]
-
- if v[0] == '"' and v[-1] == '"':
- v = v[1:-1]
- else:
- ## try to convert to a value
- try:
- v = float( v )
- v = int( v )
- except ValueError:
- pass
- except TypeError:
- pass
-
- result[n] = v
-
- return result
- def fromDict( self, d ):
- '''set attributes from a dictionary.'''
- cdef char * p
- cdef int l
-
- # clean up if this field is set twice
- if self.hasOwnAttributes:
- free(self.attributes)
-
- aa = []
- for k,v in d.items():
- if type(v) == types.StringType:
- aa.append( '%s "%s"' % (k,v) )
- else:
- aa.append( '%s %s' % (k,str(v)) )
-
- a = "; ".join( aa ) + ";"
- p = a
- l = len(a)
- self.attributes = <char *>calloc( l + 1, sizeof(char) )
- memcpy( self.attributes, p, l )
-
- self.hasOwnAttributes = True
- self.isModified = True
-
- def __str__(self):
- cdef char * cpy
- cdef int x
-
- if self.isModified:
- return "\t".join(
- (self.contig,
- self.source,
- self.feature,
- str(self.start+1),
- str(self.end),
- toDot(self.score),
- self.strand,
- self.frame,
- self.attributes ) )
- else:
- cpy = <char*>calloc( sizeof(char), self.nbytes+1 )
- memcpy( cpy, self.data, self.nbytes+1)
- for x from 0 <= x < self.nbytes:
- if cpy[x] == '\0': cpy[x] = '\t'
- result = cpy
- free(cpy)
- return result
-
- def invert( self, int lcontig ):
- '''invert coordinates to negative strand coordinates
-
- This method will only act if the feature is on the
- negative strand.'''
-
- if self.strand[0] == '-':
- start = min(self.start, self.end)
- end = max(self.start, self.end)
- self.start, self.end = lcontig - end, lcontig - start
+ cdef char * s
+ cdef int len
- def keys( self ):
- '''return a list of attributes defined in this entry.'''
- r = self.attributes
- return [ x.strip().split(" ")[0] for x in r.split(";") if x.strip() != '' ]
+ # Getting the metachar is a pain as ti_index_t is incomplete type.
+ # simply use '#' for now.
+ s = ti_read(self.tabixfile, self.iterator, &len)
+ if s == NULL: raise StopIteration
+ # stop at first non-header line
+ if s[0] != '#': raise StopIteration
- def __getitem__(self, item):
- return self.__getattr__( item )
+ return s
def __dealloc__(self):
- if self.data != NULL:
- free(self.data)
- if self.hasOwnAttributes:
- free(self.attributes)
-
- def __getattr__(self, item ):
- """Generic lookup of attribute from GFF/GTF attributes
- Only called if there *isn't* an attribute with this name
- """
- cdef char * start
- cdef char * query
- cdef char * cpy
- cdef char * end
- cdef int l
- query = item
-
- start = strstr( self.attributes, query)
- if start == NULL:
- raise AttributeError("'GTFProxy' has no attribute '%s'" % item )
-
- start += strlen(query) + 1
- # skip gaps before
- while start[0] == " ": start += 1
- if start[0] == '"':
- start += 1
- end = start
- while end[0] != '\0' and end[0] != '"': end += 1
- l = end - start + 1
- cpy = <char*>calloc( l, sizeof(char ) )
- memcpy( cpy, start, l )
- cpy[l-1] = '\0'
- result = cpy
- free(cpy)
- return result
- else:
- return start
-
- def setAttribute( self, name, value ):
- '''convenience method to set an attribute.'''
- r = self.asDict()
- r[name] = value
- self.fromDict( r )
+ if <void*>self.iterator != NULL:
+ ti_iter_destroy(self.iterator)
+#########################################################
+#########################################################
+#########################################################
cdef class Parser:
pass
cdef class asTuple(Parser):
'''converts a :term:`tabix row` into a python tuple.'''
def __call__(self, char * buffer, int len):
- cdef TupleProxy r
- r = TupleProxy()
+ cdef TabProxies.TupleProxy r
+ r = TabProxies.TupleProxy()
# need to copy - there were some
# persistence issues with "present"
r.copy( buffer, len )
cdef class asGTF(Parser):
'''converts a :term:`tabix row` into a GTF record.'''
def __call__(self, char * buffer, int len):
- cdef GTFProxy r
- r = GTFProxy()
+ cdef TabProxies.GTFProxy r
+ r = TabProxies.GTFProxy()
r.copy( buffer, len )
return r
+cdef class asBed( Parser ):
+ '''converts a :term:`tabix row` into a GTF record.'''
+ def __call__(self, char * buffer, int len):
+ cdef TabProxies.BedProxy r
+ r = TabProxies.BedProxy()
+ r.copy( buffer, len )
+ return r
+
+cdef class asVCF( Parser ):
+ '''converts a :term:`tabix row` into a VCF record.'''
+ def __call__(self, char * buffer, int len ):
+ cdef TabProxies.VCFProxy r
+ r = TabProxies.VCFProxy()
+ r.copy( buffer, len )
+ return r
+
+#########################################################
+#########################################################
+#########################################################
cdef class TabixIteratorParsed:
"""iterates over mapped reads in a region.
+
+ Returns parsed data.
"""
-
+
cdef ti_iter_t iterator
cdef tabix_t * tabixfile
cdef Parser parser
cdef char * s
cdef int len
- s = ti_read(self.tabixfile, self.iterator, &len)
- if s == NULL: raise StopIteration
+ while 1:
+ s = ti_read(self.tabixfile, self.iterator, &len)
+ if s == NULL: raise StopIteration
+ # todo: read metachar from configuration
+ if s[0] != '#': break
+
return self.parser(s, len)
def __dealloc__(self):
"Tabixfile",
"asTuple",
"asGTF",
+ "asVCF",
+ "asBed",
]
--- /dev/null
+/* Generated by Cython 0.13 on Thu May 5 15:40:49 2011 */
+
+#define PY_SSIZE_T_CLEAN
+#include "Python.h"
+#ifndef Py_PYTHON_H
+ #error Python headers needed to compile C extensions, please install development version of Python.
+#else
+
+#include <stddef.h> /* For offsetof */
+#ifndef offsetof
+#define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
+#endif
+
+#if !defined(WIN32) && !defined(MS_WINDOWS)
+ #ifndef __stdcall
+ #define __stdcall
+ #endif
+ #ifndef __cdecl
+ #define __cdecl
+ #endif
+ #ifndef __fastcall
+ #define __fastcall
+ #endif
+#endif
+
+#ifndef DL_IMPORT
+ #define DL_IMPORT(t) t
+#endif
+#ifndef DL_EXPORT
+ #define DL_EXPORT(t) t
+#endif
+
+#ifndef PY_LONG_LONG
+ #define PY_LONG_LONG LONG_LONG
+#endif
+
+#if PY_VERSION_HEX < 0x02040000
+ #define METH_COEXIST 0
+ #define PyDict_CheckExact(op) (Py_TYPE(op) == &PyDict_Type)
+ #define PyDict_Contains(d,o) PySequence_Contains(d,o)
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ typedef int Py_ssize_t;
+ #define PY_SSIZE_T_MAX INT_MAX
+ #define PY_SSIZE_T_MIN INT_MIN
+ #define PY_FORMAT_SIZE_T ""
+ #define PyInt_FromSsize_t(z) PyInt_FromLong(z)
+ #define PyInt_AsSsize_t(o) PyInt_AsLong(o)
+ #define PyNumber_Index(o) PyNumber_Int(o)
+ #define PyIndex_Check(o) PyNumber_Check(o)
+ #define PyErr_WarnEx(category, message, stacklevel) PyErr_Warn(category, message)
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define Py_REFCNT(ob) (((PyObject*)(ob))->ob_refcnt)
+ #define Py_TYPE(ob) (((PyObject*)(ob))->ob_type)
+ #define Py_SIZE(ob) (((PyVarObject*)(ob))->ob_size)
+ #define PyVarObject_HEAD_INIT(type, size) \
+ PyObject_HEAD_INIT(type) size,
+ #define PyType_Modified(t)
+
+ typedef struct {
+ void *buf;
+ PyObject *obj;
+ Py_ssize_t len;
+ Py_ssize_t itemsize;
+ int readonly;
+ int ndim;
+ char *format;
+ Py_ssize_t *shape;
+ Py_ssize_t *strides;
+ Py_ssize_t *suboffsets;
+ void *internal;
+ } Py_buffer;
+
+ #define PyBUF_SIMPLE 0
+ #define PyBUF_WRITABLE 0x0001
+ #define PyBUF_FORMAT 0x0004
+ #define PyBUF_ND 0x0008
+ #define PyBUF_STRIDES (0x0010 | PyBUF_ND)
+ #define PyBUF_C_CONTIGUOUS (0x0020 | PyBUF_STRIDES)
+ #define PyBUF_F_CONTIGUOUS (0x0040 | PyBUF_STRIDES)
+ #define PyBUF_ANY_CONTIGUOUS (0x0080 | PyBUF_STRIDES)
+ #define PyBUF_INDIRECT (0x0100 | PyBUF_STRIDES)
+
+#endif
+
+#if PY_MAJOR_VERSION < 3
+ #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
+#else
+ #define __Pyx_BUILTIN_MODULE_NAME "builtins"
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define Py_TPFLAGS_CHECKTYPES 0
+ #define Py_TPFLAGS_HAVE_INDEX 0
+#endif
+
+#if (PY_VERSION_HEX < 0x02060000) || (PY_MAJOR_VERSION >= 3)
+ #define Py_TPFLAGS_HAVE_NEWBUFFER 0
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBaseString_Type PyUnicode_Type
+ #define PyStringObject PyUnicodeObject
+ #define PyString_Type PyUnicode_Type
+ #define PyString_Check PyUnicode_Check
+ #define PyString_CheckExact PyUnicode_CheckExact
+#endif
+
+#if PY_VERSION_HEX < 0x02060000
+ #define PyBytesObject PyStringObject
+ #define PyBytes_Type PyString_Type
+ #define PyBytes_Check PyString_Check
+ #define PyBytes_CheckExact PyString_CheckExact
+ #define PyBytes_FromString PyString_FromString
+ #define PyBytes_FromStringAndSize PyString_FromStringAndSize
+ #define PyBytes_FromFormat PyString_FromFormat
+ #define PyBytes_DecodeEscape PyString_DecodeEscape
+ #define PyBytes_AsString PyString_AsString
+ #define PyBytes_AsStringAndSize PyString_AsStringAndSize
+ #define PyBytes_Size PyString_Size
+ #define PyBytes_AS_STRING PyString_AS_STRING
+ #define PyBytes_GET_SIZE PyString_GET_SIZE
+ #define PyBytes_Repr PyString_Repr
+ #define PyBytes_Concat PyString_Concat
+ #define PyBytes_ConcatAndDel PyString_ConcatAndDel
+ #define PySet_Check(obj) PyObject_TypeCheck(obj, &PySet_Type)
+ #define PyFrozenSet_Check(obj) PyObject_TypeCheck(obj, &PyFrozenSet_Type)
+#endif
+
+#ifndef PySet_CheckExact
+# define PySet_CheckExact(obj) (Py_TYPE(obj) == &PySet_Type)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyInt_Type PyLong_Type
+ #define PyInt_Check(op) PyLong_Check(op)
+ #define PyInt_CheckExact(op) PyLong_CheckExact(op)
+ #define PyInt_FromString PyLong_FromString
+ #define PyInt_FromUnicode PyLong_FromUnicode
+ #define PyInt_FromLong PyLong_FromLong
+ #define PyInt_FromSize_t PyLong_FromSize_t
+ #define PyInt_FromSsize_t PyLong_FromSsize_t
+ #define PyInt_AsLong PyLong_AsLong
+ #define PyInt_AS_LONG PyLong_AS_LONG
+ #define PyInt_AsSsize_t PyLong_AsSsize_t
+ #define PyInt_AsUnsignedLongMask PyLong_AsUnsignedLongMask
+ #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyBoolObject PyLongObject
+#endif
+
+
+#if PY_MAJOR_VERSION >= 3
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_TrueDivide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceTrueDivide(x,y)
+#else
+ #define __Pyx_PyNumber_Divide(x,y) PyNumber_Divide(x,y)
+ #define __Pyx_PyNumber_InPlaceDivide(x,y) PyNumber_InPlaceDivide(x,y)
+#endif
+
+#if PY_MAJOR_VERSION >= 3
+ #define PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : PyInstanceMethod_New(func))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),((char *)(n)))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),((char *)(n)),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),((char *)(n)))
+#else
+ #define __Pyx_GetAttrString(o,n) PyObject_GetAttrString((o),(n))
+ #define __Pyx_SetAttrString(o,n,a) PyObject_SetAttrString((o),(n),(a))
+ #define __Pyx_DelAttrString(o,n) PyObject_DelAttrString((o),(n))
+#endif
+
+#if PY_VERSION_HEX < 0x02050000
+ #define __Pyx_NAMESTR(n) ((char *)(n))
+ #define __Pyx_DOCSTR(n) ((char *)(n))
+#else
+ #define __Pyx_NAMESTR(n) (n)
+ #define __Pyx_DOCSTR(n) (n)
+#endif
+
+#ifdef __cplusplus
+#define __PYX_EXTERN_C extern "C"
+#else
+#define __PYX_EXTERN_C extern
+#endif
+
+#if defined(WIN32) || defined(MS_WINDOWS)
+#define _USE_MATH_DEFINES
+#endif
+#include <math.h>
+#define __PYX_HAVE_API__cvcf
+#include "stdlib.h"
+#include "string.h"
+#include "stdint.h"
+#include "stdio.h"
+#include "ctype.h"
+#include "sys/types.h"
+#include "sys/stat.h"
+#include "fcntl.h"
+#include "unistd.h"
+#include "bgzf.h"
+#include "tabix.h"
+
+/* inline attribute */
+#ifndef CYTHON_INLINE
+ #if defined(__GNUC__)
+ #define CYTHON_INLINE __inline__
+ #elif defined(_MSC_VER)
+ #define CYTHON_INLINE __inline
+ #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
+ #define CYTHON_INLINE inline
+ #else
+ #define CYTHON_INLINE
+ #endif
+#endif
+
+/* unused attribute */
+#ifndef CYTHON_UNUSED
+# if defined(__GNUC__)
+# if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+# elif defined(__ICC) || defined(__INTEL_COMPILER)
+# define CYTHON_UNUSED __attribute__ ((__unused__))
+# else
+# define CYTHON_UNUSED
+# endif
+#endif
+
+typedef struct {PyObject **p; char *s; const long n; const char* encoding; const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry; /*proto*/
+
+
+/* Type Conversion Predeclarations */
+
+#define __Pyx_PyBytes_FromUString(s) PyBytes_FromString((char*)s)
+#define __Pyx_PyBytes_AsUString(s) ((unsigned char*) PyBytes_AsString(s))
+
+#define __Pyx_PyBool_FromLong(b) ((b) ? (Py_INCREF(Py_True), Py_True) : (Py_INCREF(Py_False), Py_False))
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x);
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject*);
+
+#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
+
+
+#ifdef __GNUC__
+/* Test for GCC > 2.95 */
+#if __GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95))
+#define likely(x) __builtin_expect(!!(x), 1)
+#define unlikely(x) __builtin_expect(!!(x), 0)
+#else /* __GNUC__ > 2 ... */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ > 2 ... */
+#else /* __GNUC__ */
+#define likely(x) (x)
+#define unlikely(x) (x)
+#endif /* __GNUC__ */
+
+static PyObject *__pyx_m;
+static PyObject *__pyx_b;
+static PyObject *__pyx_empty_tuple;
+static PyObject *__pyx_empty_bytes;
+static int __pyx_lineno;
+static int __pyx_clineno = 0;
+static const char * __pyx_cfilenm= __FILE__;
+static const char *__pyx_filename;
+
+
+static const char *__pyx_f[] = {
+ "cvcf.pyx",
+ "ctabix.pxd",
+ "TabProxies.pxd",
+};
+
+/* Type declarations */
+
+/* "pysam/TabProxies.pxd":42
+ * ctypedef int uint64_t
+ *
+ * cdef class TupleProxy: # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_TupleProxy {
+ PyObject_HEAD
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtab;
+ char *data;
+ char **fields;
+ int nfields;
+ int index;
+ int nbytes;
+ int offset;
+ int is_modified;
+};
+
+/* "pysam/TabProxies.pxd":77
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class NamedTupleProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ * pass
+ *
+ */
+
+struct __pyx_obj_10TabProxies_NamedTupleProxy {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+};
+
+/* "pysam/TabProxies.pxd":80
+ * pass
+ *
+ * cdef class BedProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_BedProxy {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+ char *contig;
+ uint32_t start;
+ uint32_t end;
+ int bedfields;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":94
+ * ###########################################################################################################
+ *
+ * cdef class VCFRecord( TabProxies.TupleProxy): # <<<<<<<<<<<<<<
+ * '''vcf record.
+ *
+ */
+
+struct __pyx_obj_4cvcf_VCFRecord {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+ PyObject *vcf;
+ char *contig;
+ uint32_t pos;
+};
+
+/* "pysam/TabProxies.pxd":91
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class VCFProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_VCFProxy {
+ struct __pyx_obj_10TabProxies_NamedTupleProxy __pyx_base;
+ char *contig;
+ uint32_t pos;
+};
+
+/* "pysam/ctabix.pxd":178
+ * cdef tabix_t * tabixfile
+ *
+ * cdef class Parser: # <<<<<<<<<<<<<<
+ * pass
+ */
+
+struct __pyx_obj_6ctabix_Parser {
+ PyObject_HEAD
+};
+
+/* "pysam/TabProxies.pxd":60
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class GTFProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_obj_10TabProxies_GTFProxy {
+ struct __pyx_obj_10TabProxies_TupleProxy __pyx_base;
+ char *contig;
+ char *source;
+ char *feature;
+ uint32_t start;
+ uint32_t end;
+ char *score;
+ char *strand;
+ char *frame;
+ char *attributes;
+ int hasOwnAttributes;
+};
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":221
+ *
+ *
+ * cdef class asVCFRecord( ctabix.Parser ): # <<<<<<<<<<<<<<
+ * '''converts a :term:`tabix row` into a VCF record.'''
+ * cdef vcffile
+ */
+
+struct __pyx_obj_4cvcf_asVCFRecord {
+ struct __pyx_obj_6ctabix_Parser __pyx_base;
+ PyObject *vcffile;
+};
+
+/* "pysam/ctabix.pxd":172
+ * # char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
+ *
+ * cdef class Tabixfile: # <<<<<<<<<<<<<<
+ * cdef char * filename
+ *
+ */
+
+struct __pyx_obj_6ctabix_Tabixfile {
+ PyObject_HEAD
+ char *filename;
+ tabix_t *tabixfile;
+};
+
+
+/* "pysam/TabProxies.pxd":42
+ * ctypedef int uint64_t
+ *
+ * cdef class TupleProxy: # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_TupleProxy {
+ int (*getMaxFields)(struct __pyx_obj_10TabProxies_TupleProxy *, size_t);
+ PyObject *(*take)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*present)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*copy)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+ PyObject *(*update)(struct __pyx_obj_10TabProxies_TupleProxy *, char *, size_t);
+};
+static struct __pyx_vtabstruct_10TabProxies_TupleProxy *__pyx_vtabptr_10TabProxies_TupleProxy;
+
+
+/* "pysam/TabProxies.pxd":77
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class NamedTupleProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ * pass
+ *
+ */
+
+struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy {
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy *__pyx_vtabptr_10TabProxies_NamedTupleProxy;
+
+
+/* "pysam/TabProxies.pxd":91
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class VCFProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_VCFProxy {
+ struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_VCFProxy *__pyx_vtabptr_10TabProxies_VCFProxy;
+
+
+/* "pysam/TabProxies.pxd":60
+ * cdef update( self, char * buffer, size_t nbytes )
+ *
+ * cdef class GTFProxy( TupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_GTFProxy {
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_GTFProxy *__pyx_vtabptr_10TabProxies_GTFProxy;
+
+
+/* "/ifs/devel/pysam/pysam/pysam/cvcf.pyx":94
+ * ###########################################################################################################
+ *
+ * cdef class VCFRecord( TabProxies.TupleProxy): # <<<<<<<<<<<<<<
+ * '''vcf record.
+ *
+ */
+
+struct __pyx_vtabstruct_4cvcf_VCFRecord {
+ struct __pyx_vtabstruct_10TabProxies_TupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_4cvcf_VCFRecord *__pyx_vtabptr_4cvcf_VCFRecord;
+
+
+/* "pysam/TabProxies.pxd":80
+ * pass
+ *
+ * cdef class BedProxy( NamedTupleProxy) : # <<<<<<<<<<<<<<
+ *
+ * cdef:
+ */
+
+struct __pyx_vtabstruct_10TabProxies_BedProxy {
+ struct __pyx_vtabstruct_10TabProxies_NamedTupleProxy __pyx_base;
+};
+static struct __pyx_vtabstruct_10TabProxies_BedProxy *__pyx_vtabptr_10TabProxies_BedProxy;
+
+#ifndef CYTHON_REFNANNY
+ #define CYTHON_REFNANNY 0
+#endif
+
+#if CYTHON_REFNANNY
+ typedef struct {
+ void (*INCREF)(void*, PyObject*, int);
+ void (*DECREF)(void*, PyObject*, int);
+ void (*GOTREF)(void*, PyObject*, int);
+ void (*GIVEREF)(void*, PyObject*, int);
+ void* (*SetupContext)(const char*, int, const char*);
+ void (*FinishContext)(void**);
+ } __Pyx_RefNannyAPIStruct;
+ static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
+ static __Pyx_RefNannyAPIStruct * __Pyx_RefNannyImportAPI(const char *modname) {
+ PyObject *m = NULL, *p = NULL;
+ void *r = NULL;
+ m = PyImport_ImportModule((char *)modname);
+ if (!m) goto end;
+ p = PyObject_GetAttrString(m, (char *)"RefNannyAPI");
+ if (!p) goto end;
+ r = PyLong_AsVoidPtr(p);
+ end:
+ Py_XDECREF(p);
+ Py_XDECREF(m);
+ return (__Pyx_RefNannyAPIStruct *)r;
+ }
+ #define __Pyx_RefNannySetupContext(name) void *__pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__)
+ #define __Pyx_RefNannyFinishContext() __Pyx_RefNanny->FinishContext(&__pyx_refnanny)
+ #define __Pyx_INCREF(r) __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_DECREF(r) __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_GOTREF(r) __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
+ #define __Pyx_XDECREF(r) do { if((r) != NULL) {__Pyx_DECREF(r);} } while(0)
+#else
+ #define __Pyx_RefNannySetupContext(name)
+ #define __Pyx_RefNannyFinishContext()
+ #define __Pyx_INCREF(r) Py_INCREF(r)
+ #define __Pyx_DECREF(r) Py_DECREF(r)
+ #define __Pyx_GOTREF(r)
+ #define __Pyx_GIVEREF(r)
+ #define __Pyx_XDECREF(r) Py_XDECREF(r)
+#endif /* CYTHON_REFNANNY */
+#define __Pyx_XGIVEREF(r) do { if((r) != NULL) {__Pyx_GIVEREF(r);} } while(0)
+#define __Pyx_XGOTREF(r) do { if((r) != NULL) {__Pyx_GOTREF(r);} } while(0)
+
+static PyObject *__Pyx_GetName(PyObject *dict, PyObject *name); /*proto*/
+
+static void __Pyx_RaiseDoubleKeywordsError(
+ const char* func_name, PyObject* kw_name); /*proto*/
+
+static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
+ Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found); /*proto*/
+
+static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[], PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args, const char* function_name); /*proto*/
+
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
+ PyObject *r;
+ if (!j) return NULL;
+ r = PyObject_GetItem(o, j);
+ Py_DECREF(j);
+ return r;
+}
+
+
+#define __Pyx_GetItemInt_List(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_List_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ PyObject *r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyList_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyList_GET_ITEM(o, PyList_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+#define __Pyx_GetItemInt_Tuple(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Tuple_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i) {
+ if (likely(o != Py_None)) {
+ if (likely((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ PyObject *r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ return r;
+ }
+ else if ((-PyTuple_GET_SIZE(o) <= i) & (i < 0)) {
+ PyObject *r = PyTuple_GET_ITEM(o, PyTuple_GET_SIZE(o) + i);
+ Py_INCREF(r);
+ return r;
+ }
+ }
+ return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+}
+
+
+#define __Pyx_GetItemInt(o, i, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_GetItemInt_Fast(o, i) : \
+ __Pyx_GetItemInt_Generic(o, to_py_func(i)))
+
+static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ r = PyList_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (PyTuple_CheckExact(o) && ((0 <= i) & (i < PyTuple_GET_SIZE(o)))) {
+ r = PyTuple_GET_ITEM(o, i);
+ Py_INCREF(r);
+ }
+ else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_item && (likely(i >= 0))) {
+ r = PySequence_GetItem(o, i);
+ }
+ else {
+ r = __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
+ }
+ return r;
+}
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj); /* proto */
+
+#define __Pyx_PyObject_AsDouble(obj) \
+ ((likely(PyFloat_CheckExact(obj))) ? \
+ PyFloat_AS_DOUBLE(obj) : __Pyx__PyObject_AsDouble(obj))
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void);
+
+
+#if PY_MAJOR_VERSION >= 3
+static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
+ PyObject *value;
+ if (unlikely(d == Py_None)) {
+ __Pyx_RaiseNoneIndexingError();
+ return NULL;
+ }
+ value = PyDict_GetItemWithError(d, key);
+ if (unlikely(!value)) {
+ if (!PyErr_Occurred())
+ PyErr_SetObject(PyExc_KeyError, key);
+ return NULL;
+ }
+ Py_INCREF(value);
+ return value;
+}
+#else
+ #define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
+#endif
+
+static CYTHON_INLINE long __Pyx_NegateNonNeg(long b) { return unlikely(b < 0) ? b : !b; }
+static CYTHON_INLINE PyObject* __Pyx_PyBoolOrNull_FromLong(long b) {
+ return unlikely(b < 0) ? NULL : __Pyx_PyBool_FromLong(b);
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);
+
+static PyObject *__Pyx_UnpackItem(PyObject *, Py_ssize_t index); /*proto*/
+static int __Pyx_EndUnpack(PyObject *, Py_ssize_t expected); /*proto*/
+
+static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t, Py_ssize_t); /* proto */
+
+static CYTHON_INLINE PyObject* __Pyx_PyObject_Append(PyObject* L, PyObject* x) {
+ if (likely(PyList_CheckExact(L))) {
+ if (PyList_Append(L, x) < 0) return NULL;
+ Py_INCREF(Py_None);
+ return Py_None; /* this is just to have an accurate signature */
+ }
+ else {
+ PyObject *r, *m;
+ m = __Pyx_GetAttrString(L, "append");
+ if (!m) return NULL;
+ r = PyObject_CallFunctionObjArgs(m, x, NULL);
+ Py_DECREF(m);
+ return r;
+ }
+}
+
+#define __Pyx_SetItemInt(o, i, v, size, to_py_func) (((size) <= sizeof(Py_ssize_t)) ? \
+ __Pyx_SetItemInt_Fast(o, i, v) : \
+ __Pyx_SetItemInt_Generic(o, to_py_func(i), v))
+
+static CYTHON_INLINE int __Pyx_SetItemInt_Generic(PyObject *o, PyObject *j, PyObject *v) {
+ int r;
+ if (!j) return -1;
+ r = PyObject_SetItem(o, j, v);
+ Py_DECREF(j);
+ return r;
+}
+
+static CYTHON_INLINE int __Pyx_SetItemInt_Fast(PyObject *o, Py_ssize_t i, PyObject *v) {
+ if (PyList_CheckExact(o) && ((0 <= i) & (i < PyList_GET_SIZE(o)))) {
+ Py_INCREF(v);
+ Py_DECREF(PyList_GET_ITEM(o, i));
+ PyList_SET_ITEM(o, i, v);
+ return 1;
+ }
+ else if (Py_TYPE(o)->tp_as_sequence && Py_TYPE(o)->tp_as_sequence->sq_ass_item && (likely(i >= 0)))
+ return PySequence_SetItem(o, i, v);
+ else {
+ PyObject *j = PyInt_FromSsize_t(i);
+ return __Pyx_SetItemInt_Generic(o, j, v);
+ }
+}
+
+#if PY_VERSION_HEX < 0x02050000
+#ifndef PyAnySet_CheckExact
+
+#define PyAnySet_CheckExact(ob) \
+ ((ob)->ob_type == &PySet_Type || \
+ (ob)->ob_type == &PyFrozenSet_Type)
+
+#define PySet_New(iterable) \
+ PyObject_CallFunctionObjArgs((PyObject *)&PySet_Type, (iterable), NULL)
+
+#define Pyx_PyFrozenSet_New(iterable) \
+ PyObject_CallFunctionObjArgs((PyObject *)&PyFrozenSet_Type, (iterable), NULL)
+
+#define PySet_Size(anyset) \
+ PyObject_Size((anyset))
+
+#define PySet_Contains(anyset, key) \
+ PySequence_Contains((anyset), (key))
+
+#define PySet_Pop(set) \
+ PyObject_CallMethod(set, (char *)"pop", NULL)
+
+static CYTHON_INLINE int PySet_Clear(PyObject *set) {
+ PyObject *ret = PyObject_CallMethod(set, (char *)"clear", NULL);
+ if (!ret) return -1;
+ Py_DECREF(ret); return 0;
+}
+
+static CYTHON_INLINE int PySet_Discard(PyObject *set, PyObject *key) {
+ PyObject *ret = PyObject_CallMethod(set, (char *)"discard", (char *)"O", key);
+ if (!ret) return -1;
+ Py_DECREF(ret); return 0;
+}
+
+static CYTHON_INLINE int PySet_Add(PyObject *set, PyObject *key) {
+ PyObject *ret = PyObject_CallMethod(set, (char *)"add", (char *)"O", key);
+ if (!ret) return -1;
+ Py_DECREF(ret); return 0;
+}
+
+#endif /* PyAnySet_CheckExact (<= Py2.4) */
+
+#if PY_VERSION_HEX < 0x02040000
+#ifndef Py_SETOBJECT_H
+#define Py_SETOBJECT_H
+
+static PyTypeObject *__Pyx_PySet_Type = NULL;
+static PyTypeObject *__Pyx_PyFrozenSet_Type = NULL;
+
+#define PySet_Type (*__Pyx_PySet_Type)
+#define PyFrozenSet_Type (*__Pyx_PyFrozenSet_Type)
+
+#define PyAnySet_Check(ob) \
+ (PyAnySet_CheckExact(ob) || \
+ PyType_IsSubtype((ob)->ob_type, &PySet_Type) || \
+ PyType_IsSubtype((ob)->ob_type, &PyFrozenSet_Type))
+
+#define PyFrozenSet_CheckExact(ob) ((ob)->ob_type == &PyFrozenSet_Type)
+
+static int __Pyx_Py23SetsImport(void) {
+ PyObject *sets=0, *Set=0, *ImmutableSet=0;
+
+ sets = PyImport_ImportModule((char *)"sets");
+ if (!sets) goto bad;
+ Set = PyObject_GetAttrString(sets, (char *)"Set");
+ if (!Set) goto bad;
+ ImmutableSet = PyObject_GetAttrString(sets, (char *)"ImmutableSet");
+ if (!ImmutableSet) goto bad;
+ Py_DECREF(sets);
+
+ __Pyx_PySet_Type = (PyTypeObject*) Set;
+ __Pyx_PyFrozenSet_Type = (PyTypeObject*) ImmutableSet;
+
+ return 0;
+
+ bad:
+ Py_XDECREF(sets);
+ Py_XDECREF(Set);
+ Py_XDECREF(ImmutableSet);
+ return -1;
+}
+
+#else
+static int __Pyx_Py23SetsImport(void) { return 0; }
+#endif /* !Py_SETOBJECT_H */
+#endif /* < Py2.4 */
+#endif /* < Py2.5 */
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list); /*proto*/
+
+static PyObject *__Pyx_CreateClass(PyObject *bases, PyObject *dict, PyObject *name, const char *modname); /*proto*/
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb); /*proto*/
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb); /*proto*/
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t);
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject *);
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject *);
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject *);
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject *);
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject *);
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject *);
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject *);
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject *);
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject *);
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject *);
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject *);
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject *);
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject *);
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject *);
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject *);
+
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name, long size, int strict); /*proto*/
+
+static PyObject *__Pyx_ImportModule(const char *name); /*proto*/
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr); /*proto*/
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable); /*proto*/
+
+static void __Pyx_AddTraceback(const char *funcname); /*proto*/
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t); /*proto*/
+/* Module declarations from ctabix */
+
+static PyTypeObject *__pyx_ptype_6ctabix_Tabixfile = 0;
+static PyTypeObject *__pyx_ptype_6ctabix_Parser = 0;
+/* Module declarations from TabProxies */
+
+static PyTypeObject *__pyx_ptype_10TabProxies_TupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_GTFProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_NamedTupleProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_BedProxy = 0;
+static PyTypeObject *__pyx_ptype_10TabProxies_VCFProxy = 0;
+/* Module declarations from cvcf */
+
+static PyTypeObject *__pyx_ptype_4cvcf_VCFRecord = 0;
+static PyTypeObject *__pyx_ptype_4cvcf_asVCFRecord = 0;
+#define __Pyx_MODULE_NAME "cvcf"
+int __pyx_module_is_main_cvcf = 0;
+
+/* Implementation of cvcf */
+static PyObject *__pyx_builtin_object;
+static PyObject *__pyx_builtin_ValueError;
+static PyObject *__pyx_builtin_range;
+static PyObject *__pyx_builtin_enumerate;
+static PyObject *__pyx_builtin_map;
+static PyObject *__pyx_builtin_min;
+static PyObject *__pyx_builtin_len;
+static PyObject *__pyx_builtin_zip;
+static PyObject *__pyx_builtin_StopIteration;
+static PyObject *__pyx_builtin_KeyError;
+static PyObject *__pyx_builtin_NotImplementedError;
+static char __pyx_k_1[] = "";
+static char __pyx_k_2[] = ",";
+static char __pyx_k_3[] = ":";
+static char __pyx_k_4[] = "-";
+static char __pyx_k_5[] = "Don't understand region string '%s'";
+static char __pyx_k_6[] = ".";
+static char __pyx_k_7[] = ";";
+static char __pyx_k_8[] = "=";
+static char __pyx_k_9[] = "BAD_NUMBER_OF_VALUES";
+static char __pyx_k_10[] = "(found %s values in element %s; expected %s)";
+static char __pyx_k_11[] = "BAD_NUMBER_OF_PARAMETERS";
+static char __pyx_k_12[] = "id=%s, expected %s parameters, got %s";
+static char __pyx_k_14[] = "Line %s: '%s'\n%s %s: %s\n";
+static char __pyx_k_16[] = "<";
+static char __pyx_k_17[] = "V40_MISSING_ANGLE_BRACKETS";
+static char __pyx_k_18[] = ">";
+static char __pyx_k_19[] = "\"";
+static char __pyx_k_20[] = "V40_FORMAT_MUST_HAVE_NAMED_FIELDS";
+static char __pyx_k_21[] = "BADLY_FORMATTED_FORMAT_STRING";
+static char __pyx_k_22[] = "ID=";
+static char __pyx_k_23[] = "Number=";
+static char __pyx_k_24[] = "Type=";
+static char __pyx_k_25[] = "Description=";
+static char __pyx_k_26[] = "FORMAT_MISSING_QUOTES";
+static char __pyx_k_27[] = "<none>";
+static char __pyx_k_28[] = "#alleles";
+static char __pyx_k_29[] = "#nonref_alleles";
+static char __pyx_k_30[] = "#genotypes";
+static char __pyx_k_31[] = "#phased_genotypes";
+static char __pyx_k_33[] = "Unknown number type encountered: %s";
+static char __pyx_k_34[] = "%s=%s";
+static char __pyx_k_35[] = "(Undefined tag)";
+static char __pyx_k_38[] = "(output)";
+static char __pyx_k_39[] = "Genotype Quality";
+static char __pyx_k_40[] = "Read depth at this position for this sample";
+static char __pyx_k_41[] = "Haplotype Quality";
+static char __pyx_k_42[] = "Sample Genotype Filter";
+static char __pyx_k_43[] = "##";
+static char __pyx_k_44[] = "VCFv3.3";
+static char __pyx_k_45[] = "VCFv4.0";
+static char __pyx_k_46[] = "VCFv4.1";
+static char __pyx_k_47[] = "UNKNOWN_FORMAT_STRING";
+static char __pyx_k_48[] = "##fileformat=VCFv%s.%s\n";
+static char __pyx_k_49[] = "##%s=%s\n";
+static char __pyx_k_50[] = "#";
+static char __pyx_k_51[] = "\t";
+static char __pyx_k_52[] = "HEADING_NOT_SEPARATED_BY_TABS";
+static char __pyx_k_53[] = "(%sth entry not found)";
+static char __pyx_k_54[] = "(found %s, expected %s)";
+static char __pyx_k_55[] = "BADLY_FORMATTED_HEADING";
+static char __pyx_k_56[] = "\n";
+static char __pyx_k_57[] = "|";
+static char __pyx_k_58[] = "ERROR_FLAG_HAS_VALUE";
+static char __pyx_k_59[] = "ERROR_FORMAT_NOT_NUMERICAL";
+static char __pyx_k_60[] = "ERROR_FORMAT_NOT_CHAR";
+static char __pyx_k_62[] = "BAD_NUMBER_OF_COLUMNS";
+static char __pyx_k_63[] = "expected %s for %s samples (%s), got %s";
+static char __pyx_k_64[] = "(reference is %s, VCF says %s)";
+static char __pyx_k_65[] = "V33_UNMATCHED_DELETION";
+static char __pyx_k_66[] = "(deletion is %s, reference is %s)";
+static char __pyx_k_67[] = "MISSING_INDEL_ALLELE_REF_BASE";
+static char __pyx_k_68[] = "Required key %s not found in data";
+static char __pyx_k_69[] = "enter_default_format";
+static char __pyx_k_70[] = "Can only handle v3.3 and v4.0 VCF files";
+static char __pyx_k_71[] = "Invalid error string: %s";
+static char __pyx_k_72[] = "needs to be checked";
+static char __pyx_k_73[] = "[|/\\\\]";
+static char __pyx_k_74[] = "^[ACGTN]+$";
+static char __pyx_k_75[] = "id numbertype number type description missingvalue";
+static char __pyx_k_76[] = "UNKNOWN_FORMAT_STRING:Unknown file format identifier";
+static char __pyx_k_77[] = "BADLY_FORMATTED_FORMAT_STRING:Formatting error in the format string";
+static char __pyx_k_78[] = "BADLY_FORMATTED_HEADING:Did not find 9 required headings (CHROM, POS, ..., FORMAT) %s";
+static char __pyx_k_79[] = "BAD_NUMBER_OF_COLUMNS:Wrong number of columns found (%s)";
+static char __pyx_k_80[] = "POS_NOT_NUMERICAL:Position column is not numerical";
+static char __pyx_k_81[] = "UNKNOWN_CHAR_IN_REF:Unknown character in reference field";
+static char __pyx_k_82[] = "V33_BAD_REF:Reference should be single-character in v3.3 VCF";
+static char __pyx_k_83[] = "V33_BAD_ALLELE:Cannot interpret allele for v3.3 VCF";
+static char __pyx_k_84[] = "POS_NOT_POSITIVE:Position field must be >0";
+static char __pyx_k_85[] = "QUAL_NOT_NUMERICAL:Quality field must be numerical, or '.'";
+static char __pyx_k_86[] = "ERROR_INFO_STRING:Error while parsing info field";
+static char __pyx_k_87[] = "ERROR_UNKNOWN_KEY:Unknown key (%s) found in formatted field (info; format; or filter)";
+static char __pyx_k_88[] = "ERROR_FORMAT_NOT_NUMERICAL:Expected integer or float in formatted field; got %s";
+static char __pyx_k_89[] = "ERROR_FORMAT_NOT_CHAR:Eexpected character in formatted field; got string";
+static char __pyx_k_90[] = "FILTER_NOT_DEFINED:Identifier (%s) in filter found which was not defined in header";
+static char __pyx_k_91[] = "FORMAT_NOT_DEFINED:Identifier (%s) in format found which was not defined in header";
+static char __pyx_k_92[] = "BAD_NUMBER_OF_VALUES:Found too many of values in sample column (%s)";
+static char __pyx_k_93[] = "BAD_NUMBER_OF_PARAMETERS:Found unexpected number of parameters (%s)";
+static char __pyx_k_94[] = "BAD_GENOTYPE:Cannot parse genotype (%s)";
+static char __pyx_k_95[] = "V40_BAD_ALLELE:Bad allele found for v4.0 VCF (%s)";
+static char __pyx_k_96[] = "MISSING_REF:Reference allele missing";
+static char __pyx_k_97[] = "V33_UNMATCHED_DELETION:Deleted sequence does not match reference (%s)";
+static char __pyx_k_98[] = "V40_MISSING_ANGLE_BRACKETS:Format definition is not deliminted by angular brackets";
+static char __pyx_k_99[] = "FORMAT_MISSING_QUOTES:Description field in format definition is not surrounded by quotes";
+static char __pyx_k__0[] = "0";
+static char __pyx_k__D[] = "D";
+static char __pyx_k__I[] = "I";
+static char __pyx_k__N[] = "N";
+static char __pyx_k_100[] = "V40_FORMAT_MUST_HAVE_NAMED_FIELDS:Fields in v4.0 VCF format definition must have named fields";
+static char __pyx_k_101[] = "HEADING_NOT_SEPARATED_BY_TABS:Heading line appears separated by spaces, not tabs";
+static char __pyx_k_102[] = "WRONG_REF:Wrong reference %s";
+static char __pyx_k_103[] = "ERROR_TRAILING_DATA:Numerical field ('%s') has semicolon-separated trailing data";
+static char __pyx_k_104[] = "BAD_CHR_TAG:Error calculating chr tag for %s";
+static char __pyx_k_105[] = "ZERO_LENGTH_ALLELE:Found zero-length allele";
+static char __pyx_k_106[] = "MISSING_INDEL_ALLELE_REF_BASE:Indel alleles must begin with single reference base";
+static char __pyx_k_107[] = "VCF.getsamples (line 880)";
+static char __pyx_k_108[] = "VCF.setsamples (line 884)";
+static char __pyx_k_109[] = "VCF.getheader (line 888)";
+static char __pyx_k_110[] = "VCF.setheader (line 892)";
+static char __pyx_k_111[] = "VCF.getinfo (line 896)";
+static char __pyx_k_112[] = "VCF.setinfo (line 900)";
+static char __pyx_k_113[] = "VCF.getformat (line 904)";
+static char __pyx_k_114[] = "VCF.setformat (line 908)";
+static char __pyx_k_115[] = "VCF.getfilter (line 912)";
+static char __pyx_k_116[] = "VCF.setfilter (line 916)";
+static char __pyx_k_117[] = "VCF.setreference (line 927)";
+static char __pyx_k_118[] = "VCF.parse (line 939)";
+static char __pyx_k_119[] = "VCF.write (line 946)";
+static char __pyx_k_120[] = "VCF.writeheader (line 952)";
+static char __pyx_k_121[] = "VCF.compare_calls (line 957)";
+static char __pyx_k_122[] = "VCF.connect (line 979)";
+static char __pyx_k_123[] = "VCF.fetch (line 984)";
+static char __pyx_k_124[] = "VCF.validate (line 993)";
+static char __pyx_k__DP[] = "DP";
+static char __pyx_k__FT[] = "FT";
+static char __pyx_k__GQ[] = "GQ";
+static char __pyx_k__GT[] = "GT";
+static char __pyx_k__HQ[] = "HQ";
+static char __pyx_k__ID[] = "ID";
+static char __pyx_k__fa[] = "fa";
+static char __pyx_k__id[] = "id";
+static char __pyx_k__re[] = "re";
+static char __pyx_k__ALT[] = "ALT";
+static char __pyx_k__POS[] = "POS";
+static char __pyx_k__REF[] = "REF";
+static char __pyx_k__VCF[] = "VCF";
+static char __pyx_k__add[] = "add";
+static char __pyx_k__alt[] = "alt";
+static char __pyx_k__end[] = "end";
+static char __pyx_k__fmt[] = "fmt";
+static char __pyx_k__get[] = "get";
+static char __pyx_k__key[] = "key";
+static char __pyx_k__len[] = "len";
+static char __pyx_k__map[] = "map";
+static char __pyx_k__min[] = "min";
+static char __pyx_k__opt[] = "opt";
+static char __pyx_k__pos[] = "pos";
+static char __pyx_k__ref[] = "ref";
+static char __pyx_k__sys[] = "sys";
+static char __pyx_k__vcf[] = "vcf";
+static char __pyx_k__zip[] = "zip";
+static char __pyx_k__Flag[] = "Flag";
+static char __pyx_k__INFO[] = "INFO";
+static char __pyx_k__PASS[] = "PASS";
+static char __pyx_k__QUAL[] = "QUAL";
+static char __pyx_k__Type[] = "Type";
+static char __pyx_k__alt1[] = "alt1";
+static char __pyx_k__alt2[] = "alt2";
+static char __pyx_k__copy[] = "copy";
+static char __pyx_k__data[] = "data";
+static char __pyx_k__find[] = "find";
+static char __pyx_k__info[] = "info";
+static char __pyx_k__join[] = "join";
+static char __pyx_k__keys[] = "keys";
+static char __pyx_k__line[] = "line";
+static char __pyx_k__pos1[] = "pos1";
+static char __pyx_k__pos2[] = "pos2";
+static char __pyx_k__qual[] = "qual";
+static char __pyx_k__ref1[] = "ref1";
+static char __pyx_k__ref2[] = "ref2";
+static char __pyx_k__self[] = "self";
+static char __pyx_k__type[] = "type";
+static char __pyx_k__ACGTN[] = "ACGTN";
+static char __pyx_k__CHROM[] = "CHROM";
+static char __pyx_k__Error[] = "Error";
+static char __pyx_k__Float[] = "Float";
+static char __pyx_k___copy[] = "_copy";
+static char __pyx_k___info[] = "_info";
+static char __pyx_k___line[] = "_line";
+static char __pyx_k__chrom[] = "chrom";
+static char __pyx_k__descr[] = "descr";
+static char __pyx_k__error[] = "error";
+static char __pyx_k__fetch[] = "fetch";
+static char __pyx_k__lines[] = "lines";
+static char __pyx_k__match[] = "match";
+static char __pyx_k__parse[] = "parse";
+static char __pyx_k__pysam[] = "pysam";
+static char __pyx_k__range[] = "range";
+static char __pyx_k__split[] = "split";
+static char __pyx_k__start[] = "start";
+static char __pyx_k__strip[] = "strip";
+static char __pyx_k__upper[] = "upper";
+static char __pyx_k__value[] = "value";
+static char __pyx_k__write[] = "write";
+static char __pyx_k__FILTER[] = "FILTER";
+static char __pyx_k__FORMAT[] = "FORMAT";
+static char __pyx_k__GTdata[] = "GTdata";
+static char __pyx_k__Number[] = "Number";
+static char __pyx_k__String[] = "String";
+static char __pyx_k___lines[] = "_lines";
+static char __pyx_k___parse[] = "_parse";
+static char __pyx_k__bisect[] = "bisect";
+static char __pyx_k__buffer[] = "buffer";
+static char __pyx_k__contig[] = "contig";
+static char __pyx_k__fields[] = "fields";
+static char __pyx_k__filter[] = "filter";
+static char __pyx_k__format[] = "format";
+static char __pyx_k__header[] = "header";
+static char __pyx_k__number[] = "number";
+static char __pyx_k__object[] = "object";
+static char __pyx_k__offset[] = "offset";
+static char __pyx_k__parser[] = "parser";
+static char __pyx_k__record[] = "record";
+static char __pyx_k__region[] = "region";
+static char __pyx_k__stderr[] = "stderr";
+static char __pyx_k__stream[] = "stream";
+static char __pyx_k__Integer[] = "Integer";
+static char __pyx_k__Warning[] = "Warning";
+static char __pyx_k____all__[] = "__all__";
+static char __pyx_k___errors[] = "_errors";
+static char __pyx_k___filter[] = "_filter";
+static char __pyx_k___format[] = "_format";
+static char __pyx_k___header[] = "_header";
+static char __pyx_k___lineno[] = "_lineno";
+static char __pyx_k__compile[] = "compile";
+static char __pyx_k__connect[] = "connect";
+static char __pyx_k__getinfo[] = "getinfo";
+static char __pyx_k__missing[] = "missing";
+static char __pyx_k__nfields[] = "nfields";
+static char __pyx_k__regions[] = "regions";
+static char __pyx_k__replace[] = "replace";
+static char __pyx_k__samples[] = "samples";
+static char __pyx_k__setinfo[] = "setinfo";
+static char __pyx_k__vcffile[] = "vcffile";
+static char __pyx_k__version[] = "version";
+static char __pyx_k__GTstring[] = "GTstring";
+static char __pyx_k__Genotype[] = "Genotype";
+static char __pyx_k__KeyError[] = "KeyError";
+static char __pyx_k____dict__[] = "__dict__";
+static char __pyx_k____init__[] = "__init__";
+static char __pyx_k____main__[] = "__main__";
+static char __pyx_k____test__[] = "__test__";
+static char __pyx_k___regions[] = "_regions";
+static char __pyx_k___samples[] = "_samples";
+static char __pyx_k___version[] = "_version";
+static char __pyx_k__deepcopy[] = "deepcopy";
+static char __pyx_k__endswith[] = "endswith";
+static char __pyx_k__filename[] = "filename";
+static char __pyx_k__gtsRegEx[] = "gtsRegEx";
+static char __pyx_k__inregion[] = "inregion";
+static char __pyx_k__operator[] = "operator";
+static char __pyx_k__validate[] = "validate";
+static char __pyx_k__Character[] = "Character";
+static char __pyx_k__NT_NUMBER[] = "NT_NUMBER";
+static char __pyx_k__Tabixfile[] = "Tabixfile";
+static char __pyx_k__VCFRecord[] = "VCFRecord";
+static char __pyx_k__WRONG_REF[] = "WRONG_REF";
+static char __pyx_k___required[] = "_required";
+static char __pyx_k__convertGT[] = "convertGT";
+static char __pyx_k__enumerate[] = "enumerate";
+static char __pyx_k__getfilter[] = "getfilter";
+static char __pyx_k__getformat[] = "getformat";
+static char __pyx_k__getheader[] = "getheader";
+static char __pyx_k__leftalign[] = "leftalign";
+static char __pyx_k__lineparse[] = "lineparse";
+static char __pyx_k__reference[] = "reference";
+static char __pyx_k__separator[] = "separator";
+static char __pyx_k__setfilter[] = "setfilter";
+static char __pyx_k__setformat[] = "setformat";
+static char __pyx_k__setheader[] = "setheader";
+static char __pyx_k__tabixfile[] = "tabixfile";
+static char __pyx_k__warnerror[] = "warnerror";
+static char __pyx_k__NT_ALLELES[] = "NT_ALLELES";
+static char __pyx_k__NT_UNKNOWN[] = "NT_UNKNOWN";
+static char __pyx_k__ValueError[] = "ValueError";
+static char __pyx_k___leftalign[] = "_leftalign";
+static char __pyx_k___reference[] = "_reference";
+static char __pyx_k__fileformat[] = "fileformat";
+static char __pyx_k__formatdict[] = "formatdict";
+static char __pyx_k__getsamples[] = "getsamples";
+static char __pyx_k__itemgetter[] = "itemgetter";
+static char __pyx_k__itervalues[] = "itervalues";
+static char __pyx_k__namedtuple[] = "namedtuple";
+static char __pyx_k__numbertype[] = "numbertype";
+static char __pyx_k__parse_data[] = "parse_data";
+static char __pyx_k__setregions[] = "setregions";
+static char __pyx_k__setsamples[] = "setsamples";
+static char __pyx_k__setversion[] = "setversion";
+static char __pyx_k__startswith[] = "startswith";
+static char __pyx_k__write_data[] = "write_data";
+static char __pyx_k__Description[] = "Description";
+static char __pyx_k__MISSING_REF[] = "MISSING_REF";
+static char __pyx_k__V33_BAD_REF[] = "V33_BAD_REF";
+static char __pyx_k__alleleRegEx[] = "alleleRegEx";
+static char __pyx_k__collections[] = "collections";
+static char __pyx_k__defaultdict[] = "defaultdict";
+static char __pyx_k__description[] = "description";
+static char __pyx_k__errorstring[] = "errorstring";
+static char __pyx_k__ignoreerror[] = "ignoreerror";
+static char __pyx_k__writeheader[] = "writeheader";
+static char __pyx_k__BAD_GENOTYPE[] = "BAD_GENOTYPE";
+static char __pyx_k__NT_GENOTYPES[] = "NT_GENOTYPES";
+static char __pyx_k___warn_errors[] = "_warn_errors";
+static char __pyx_k__get_expected[] = "get_expected";
+static char __pyx_k__get_sequence[] = "get_sequence";
+static char __pyx_k__missingvalue[] = "missingvalue";
+static char __pyx_k__parse_format[] = "parse_format";
+static char __pyx_k__parse_header[] = "parse_header";
+static char __pyx_k__setreference[] = "setreference";
+static char __pyx_k__write_header[] = "write_header";
+static char __pyx_k__NT_NR_ALLELES[] = "NT_NR_ALLELES";
+static char __pyx_k__StopIteration[] = "StopIteration";
+static char __pyx_k___parse_header[] = "_parse_header";
+static char __pyx_k__compare_calls[] = "compare_calls";
+static char __pyx_k__convertGTback[] = "convertGTback";
+static char __pyx_k__datagenerator[] = "datagenerator";
+static char __pyx_k__format_format[] = "format_format";
+static char __pyx_k__parse_heading[] = "parse_heading";
+static char __pyx_k__write_heading[] = "write_heading";
+static char __pyx_k__V33_BAD_ALLELE[] = "V33_BAD_ALLELE";
+static char __pyx_k__V40_BAD_ALLELE[] = "V40_BAD_ALLELE";
+static char __pyx_k___sample2column[] = "_sample2column";
+static char __pyx_k___add_definition[] = "_add_definition";
+static char __pyx_k___ignored_errors[] = "_ignored_errors";
+static char __pyx_k__POS_NOT_POSITIVE[] = "POS_NOT_POSITIVE";
+static char __pyx_k__parse_formatdata[] = "parse_formatdata";
+static char __pyx_k__ERROR_INFO_STRING[] = "ERROR_INFO_STRING";
+static char __pyx_k__ERROR_UNKNOWN_KEY[] = "ERROR_UNKNOWN_KEY";
+static char __pyx_k__POS_NOT_NUMERICAL[] = "POS_NOT_NUMERICAL";
+static char __pyx_k__format_formatdata[] = "format_formatdata";
+static char __pyx_k__FILTER_NOT_DEFINED[] = "FILTER_NOT_DEFINED";
+static char __pyx_k__FORMAT_NOT_DEFINED[] = "FORMAT_NOT_DEFINED";
+static char __pyx_k__QUAL_NOT_NUMERICAL[] = "QUAL_NOT_NUMERICAL";
+static char __pyx_k__ZERO_LENGTH_ALLELE[] = "ZERO_LENGTH_ALLELE";
+static char __pyx_k__ERROR_TRAILING_DATA[] = "ERROR_TRAILING_DATA";
+static char __pyx_k__NT_PHASED_GENOTYPES[] = "NT_PHASED_GENOTYPES";
+static char __pyx_k__NotImplementedError[] = "NotImplementedError";
+static char __pyx_k__UNKNOWN_CHAR_IN_REF[] = "UNKNOWN_CHAR_IN_REF";
+static PyObject *__pyx_kp_s_1;
+static PyObject *__pyx_kp_s_10;
+static PyObject *__pyx_kp_s_100;
+static PyObject *__pyx_kp_s_101;
+static PyObject *__pyx_kp_s_102;
+static PyObject *__pyx_kp_s_103;
+static PyObject *__pyx_kp_s_104;
+static PyObject *__pyx_kp_s_105;
+static PyObject *__pyx_kp_s_106;
+static PyObject *__pyx_kp_u_107;
+static PyObject *__pyx_kp_u_108;
+static PyObject *__pyx_kp_u_109;
+static PyObject *__pyx_n_s_11;
+static PyObject *__pyx_kp_u_110;
+static PyObject *__pyx_kp_u_111;
+static PyObject *__pyx_kp_u_112;
+static PyObject *__pyx_kp_u_113;
+static PyObject *__pyx_kp_u_114;
+static PyObject *__pyx_kp_u_115;
+static PyObject *__pyx_kp_u_116;
+static PyObject *__pyx_kp_u_117;
+static PyObject *__pyx_kp_u_118;
+static PyObject *__pyx_kp_u_119;
+static PyObject *__pyx_kp_s_12;
+static PyObject *__pyx_kp_u_120;
+static PyObject *__pyx_kp_u_121;
+static PyObject *__pyx_kp_u_122;
+static PyObject *__pyx_kp_u_123;
+static PyObject *__pyx_kp_u_124;
+static PyObject *__pyx_kp_s_14;
+static PyObject *__pyx_kp_s_16;
+static PyObject *__pyx_n_s_17;
+static PyObject *__pyx_kp_s_18;
+static PyObject *__pyx_kp_s_19;
+static PyObject *__pyx_kp_s_2;
+static PyObject *__pyx_n_s_20;
+static PyObject *__pyx_n_s_21;
+static PyObject *__pyx_kp_s_22;
+static PyObject *__pyx_kp_s_23;
+static PyObject *__pyx_kp_s_24;
+static PyObject *__pyx_kp_s_25;
+static PyObject *__pyx_n_s_26;
+static PyObject *__pyx_kp_s_27;
+static PyObject *__pyx_kp_s_28;
+static PyObject *__pyx_kp_s_29;
+static PyObject *__pyx_kp_s_3;
+static PyObject *__pyx_kp_s_30;
+static PyObject *__pyx_kp_s_31;
+static PyObject *__pyx_kp_s_33;
+static PyObject *__pyx_kp_s_34;
+static PyObject *__pyx_kp_s_35;
+static PyObject *__pyx_kp_s_38;
+static PyObject *__pyx_kp_s_39;
+static PyObject *__pyx_kp_s_4;
+static PyObject *__pyx_kp_s_40;
+static PyObject *__pyx_kp_s_41;
+static PyObject *__pyx_kp_s_42;
+static PyObject *__pyx_kp_s_43;
+static PyObject *__pyx_kp_s_44;
+static PyObject *__pyx_kp_s_45;
+static PyObject *__pyx_kp_s_46;
+static PyObject *__pyx_n_s_47;
+static PyObject *__pyx_kp_s_48;
+static PyObject *__pyx_kp_s_49;
+static PyObject *__pyx_kp_s_5;
+static PyObject *__pyx_kp_s_50;
+static PyObject *__pyx_kp_s_51;
+static PyObject *__pyx_n_s_52;
+static PyObject *__pyx_kp_s_53;
+static PyObject *__pyx_kp_s_54;
+static PyObject *__pyx_n_s_55;
+static PyObject *__pyx_kp_s_56;
+static PyObject *__pyx_kp_s_57;
+static PyObject *__pyx_n_s_58;
+static PyObject *__pyx_n_s_59;
+static PyObject *__pyx_kp_b_6;
+static PyObject *__pyx_kp_s_6;
+static PyObject *__pyx_n_s_60;
+static PyObject *__pyx_n_s_62;
+static PyObject *__pyx_kp_s_63;
+static PyObject *__pyx_kp_s_64;
+static PyObject *__pyx_n_s_65;
+static PyObject *__pyx_kp_s_66;
+static PyObject *__pyx_n_s_67;
+static PyObject *__pyx_kp_s_68;
+static PyObject *__pyx_n_s_69;
+static PyObject *__pyx_kp_s_7;
+static PyObject *__pyx_kp_s_70;
+static PyObject *__pyx_kp_s_71;
+static PyObject *__pyx_kp_s_72;
+static PyObject *__pyx_kp_s_73;
+static PyObject *__pyx_kp_s_74;
+static PyObject *__pyx_kp_s_75;
+static PyObject *__pyx_kp_s_76;
+static PyObject *__pyx_kp_s_77;
+static PyObject *__pyx_kp_s_78;
+static PyObject *__pyx_kp_s_79;
+static PyObject *__pyx_kp_s_8;
+static PyObject *__pyx_kp_s_80;
+static PyObject *__pyx_kp_s_81;
+static PyObject *__pyx_kp_s_82;
+static PyObject *__pyx_kp_s_83;
+static PyObject *__pyx_kp_s_84;
+static PyObject *__pyx_kp_s_85;
+static PyObject *__pyx_kp_s_86;
+static PyObject *__pyx_kp_s_87;
+static PyObject *__pyx_kp_s_88;
+static PyObject *__pyx_kp_s_89;
+static PyObject *__pyx_n_s_9;
+static PyObject *__pyx_kp_s_90;
+static PyObject *__pyx_kp_s_91;
+static PyObject *__pyx_kp_s_92;
+static PyObject *__pyx_kp_s_93;
+static PyObject *__pyx_kp_s_94;
+static PyObject *__pyx_kp_s_95;
+static PyObject *__pyx_kp_s_96;
+static PyObject *__pyx_kp_s_97;
+static PyObject *__pyx_kp_s_98;
+static PyObject *__pyx_kp_s_99;
+static PyObject *__pyx_kp_s__0;
+static PyObject *__pyx_n_s__ACGTN;
+static PyObject *__pyx_n_s__ALT;
+static PyObject *__pyx_n_s__BAD_GENOTYPE;
+static PyObject *__pyx_n_s__CHROM;
+static PyObject *__pyx_n_s__Character;
+static PyObject *__pyx_n_s__D;
+static PyObject *__pyx_n_s__DP;
+static PyObject *__pyx_n_s__Description;
+static PyObject *__pyx_n_s__ERROR_INFO_STRING;
+static PyObject *__pyx_n_s__ERROR_TRAILING_DATA;
+static PyObject *__pyx_n_s__ERROR_UNKNOWN_KEY;
+static PyObject *__pyx_n_s__Error;
+static PyObject *__pyx_n_s__FILTER;
+static PyObject *__pyx_n_s__FILTER_NOT_DEFINED;
+static PyObject *__pyx_n_s__FORMAT;
+static PyObject *__pyx_n_s__FORMAT_NOT_DEFINED;
+static PyObject *__pyx_n_s__FT;
+static PyObject *__pyx_n_s__Flag;
+static PyObject *__pyx_n_s__Float;
+static PyObject *__pyx_n_s__GQ;
+static PyObject *__pyx_n_s__GT;
+static PyObject *__pyx_n_s__GTdata;
+static PyObject *__pyx_n_s__GTstring;
+static PyObject *__pyx_n_s__Genotype;
+static PyObject *__pyx_n_s__HQ;
+static PyObject *__pyx_n_s__I;
+static PyObject *__pyx_n_s__ID;
+static PyObject *__pyx_n_s__INFO;
+static PyObject *__pyx_n_s__Integer;
+static PyObject *__pyx_n_s__KeyError;
+static PyObject *__pyx_n_s__MISSING_REF;
+static PyObject *__pyx_n_s__N;
+static PyObject *__pyx_n_s__NT_ALLELES;
+static PyObject *__pyx_n_s__NT_GENOTYPES;
+static PyObject *__pyx_n_s__NT_NR_ALLELES;
+static PyObject *__pyx_n_s__NT_NUMBER;
+static PyObject *__pyx_n_s__NT_PHASED_GENOTYPES;
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+}
+static struct __pyx_vtabstruct_4cvcf_VCFRecord __pyx_vtable_4cvcf_VCFRecord;
+
+static PyObject *__pyx_tp_new_4cvcf_VCFRecord(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_4cvcf_VCFRecord *p;
+ PyObject *o = __pyx_ptype_10TabProxies_TupleProxy->tp_new(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_4cvcf_VCFRecord *)o);
+ p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_10TabProxies_TupleProxy*)__pyx_vtabptr_4cvcf_VCFRecord;
+ p->vcf = Py_None; Py_INCREF(Py_None);
+ if (__pyx_pf_4cvcf_9VCFRecord___cinit__(o, a, k) < 0) {
+ Py_DECREF(o); o = 0;
+ }
+ return o;
+}
+
+static void __pyx_tp_dealloc_4cvcf_VCFRecord(PyObject *o) {
+ struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+ Py_XDECREF(p->vcf);
+ __pyx_ptype_10TabProxies_TupleProxy->tp_dealloc(o);
+}
+
+static int __pyx_tp_traverse_4cvcf_VCFRecord(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+ if (__pyx_ptype_10TabProxies_TupleProxy->tp_traverse) {
+ e = __pyx_ptype_10TabProxies_TupleProxy->tp_traverse(o, v, a); if (e) return e;
+ }
+ if (p->vcf) {
+ e = (*v)(p->vcf, a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_4cvcf_VCFRecord(PyObject *o) {
+ struct __pyx_obj_4cvcf_VCFRecord *p = (struct __pyx_obj_4cvcf_VCFRecord *)o;
+ PyObject* tmp;
+ if (__pyx_ptype_10TabProxies_TupleProxy->tp_clear) {
+ __pyx_ptype_10TabProxies_TupleProxy->tp_clear(o);
+ }
+ tmp = ((PyObject*)p->vcf);
+ p->vcf = Py_None; Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+static PyObject *__pyx_sq_item_4cvcf_VCFRecord(PyObject *o, Py_ssize_t i) {
+ PyObject *r;
+ PyObject *x = PyInt_FromSsize_t(i); if(!x) return 0;
+ r = Py_TYPE(o)->tp_as_mapping->mp_subscript(o, x);
+ Py_DECREF(x);
+ return r;
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_contig(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_6contig___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_pos(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_3pos___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_id(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_2id___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_ref(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_3ref___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_alt(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_3alt___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_qual(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_4qual___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_filter(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_6filter___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_info(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_4info___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_format(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_6format___get__(o);
+}
+
+static PyObject *__pyx_getprop_4cvcf_9VCFRecord_samples(PyObject *o, void *x) {
+ return __pyx_pf_4cvcf_9VCFRecord_7samples___get__(o);
+}
+
+static PyMethodDef __pyx_methods_4cvcf_VCFRecord[] = {
+ {0, 0, 0, 0}
+};
+
+static struct PyGetSetDef __pyx_getsets_4cvcf_VCFRecord[] = {
+ {(char *)"contig", __pyx_getprop_4cvcf_9VCFRecord_contig, 0, 0, 0},
+ {(char *)"pos", __pyx_getprop_4cvcf_9VCFRecord_pos, 0, 0, 0},
+ {(char *)"id", __pyx_getprop_4cvcf_9VCFRecord_id, 0, 0, 0},
+ {(char *)"ref", __pyx_getprop_4cvcf_9VCFRecord_ref, 0, 0, 0},
+ {(char *)"alt", __pyx_getprop_4cvcf_9VCFRecord_alt, 0, 0, 0},
+ {(char *)"qual", __pyx_getprop_4cvcf_9VCFRecord_qual, 0, 0, 0},
+ {(char *)"filter", __pyx_getprop_4cvcf_9VCFRecord_filter, 0, 0, 0},
+ {(char *)"info", __pyx_getprop_4cvcf_9VCFRecord_info, 0, 0, 0},
+ {(char *)"format", __pyx_getprop_4cvcf_9VCFRecord_format, 0, 0, 0},
+ {(char *)"samples", __pyx_getprop_4cvcf_9VCFRecord_samples, 0, 0, 0},
+ {0, 0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_VCFRecord = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_VCFRecord = {
+ __pyx_pf_4cvcf_9VCFRecord___len__, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ __pyx_sq_item_4cvcf_VCFRecord, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_VCFRecord = {
+ __pyx_pf_4cvcf_9VCFRecord___len__, /*mp_length*/
+ __pyx_pf_4cvcf_9VCFRecord___getitem__, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_VCFRecord = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_4cvcf_VCFRecord = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("cvcf.VCFRecord"), /*tp_name*/
+ sizeof(struct __pyx_obj_4cvcf_VCFRecord), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_4cvcf_VCFRecord, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_VCFRecord, /*tp_as_number*/
+ &__pyx_tp_as_sequence_VCFRecord, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_VCFRecord, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ 0, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_VCFRecord, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("vcf record.\n\n initialized from data and vcf meta \n "), /*tp_doc*/
+ __pyx_tp_traverse_4cvcf_VCFRecord, /*tp_traverse*/
+ __pyx_tp_clear_4cvcf_VCFRecord, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_4cvcf_VCFRecord, /*tp_methods*/
+ 0, /*tp_members*/
+ __pyx_getsets_4cvcf_VCFRecord, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ __pyx_pf_4cvcf_9VCFRecord___init__, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_4cvcf_VCFRecord, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyObject *__pyx_tp_new_4cvcf_asVCFRecord(PyTypeObject *t, PyObject *a, PyObject *k) {
+ struct __pyx_obj_4cvcf_asVCFRecord *p;
+ PyObject *o = __pyx_ptype_6ctabix_Parser->tp_new(t, a, k);
+ if (!o) return 0;
+ p = ((struct __pyx_obj_4cvcf_asVCFRecord *)o);
+ p->vcffile = Py_None; Py_INCREF(Py_None);
+ return o;
+}
+
+static void __pyx_tp_dealloc_4cvcf_asVCFRecord(PyObject *o) {
+ struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+ Py_XDECREF(p->vcffile);
+ __pyx_ptype_6ctabix_Parser->tp_dealloc(o);
+}
+
+static int __pyx_tp_traverse_4cvcf_asVCFRecord(PyObject *o, visitproc v, void *a) {
+ int e;
+ struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+ if (__pyx_ptype_6ctabix_Parser->tp_traverse) {
+ e = __pyx_ptype_6ctabix_Parser->tp_traverse(o, v, a); if (e) return e;
+ }
+ if (p->vcffile) {
+ e = (*v)(p->vcffile, a); if (e) return e;
+ }
+ return 0;
+}
+
+static int __pyx_tp_clear_4cvcf_asVCFRecord(PyObject *o) {
+ struct __pyx_obj_4cvcf_asVCFRecord *p = (struct __pyx_obj_4cvcf_asVCFRecord *)o;
+ PyObject* tmp;
+ if (__pyx_ptype_6ctabix_Parser->tp_clear) {
+ __pyx_ptype_6ctabix_Parser->tp_clear(o);
+ }
+ tmp = ((PyObject*)p->vcffile);
+ p->vcffile = Py_None; Py_INCREF(Py_None);
+ Py_XDECREF(tmp);
+ return 0;
+}
+
+static PyMethodDef __pyx_methods_4cvcf_asVCFRecord[] = {
+ {0, 0, 0, 0}
+};
+
+static PyNumberMethods __pyx_tp_as_number_asVCFRecord = {
+ 0, /*nb_add*/
+ 0, /*nb_subtract*/
+ 0, /*nb_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_divide*/
+ #endif
+ 0, /*nb_remainder*/
+ 0, /*nb_divmod*/
+ 0, /*nb_power*/
+ 0, /*nb_negative*/
+ 0, /*nb_positive*/
+ 0, /*nb_absolute*/
+ 0, /*nb_nonzero*/
+ 0, /*nb_invert*/
+ 0, /*nb_lshift*/
+ 0, /*nb_rshift*/
+ 0, /*nb_and*/
+ 0, /*nb_xor*/
+ 0, /*nb_or*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_coerce*/
+ #endif
+ 0, /*nb_int*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_long*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*nb_float*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_oct*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_hex*/
+ #endif
+ 0, /*nb_inplace_add*/
+ 0, /*nb_inplace_subtract*/
+ 0, /*nb_inplace_multiply*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*nb_inplace_divide*/
+ #endif
+ 0, /*nb_inplace_remainder*/
+ 0, /*nb_inplace_power*/
+ 0, /*nb_inplace_lshift*/
+ 0, /*nb_inplace_rshift*/
+ 0, /*nb_inplace_and*/
+ 0, /*nb_inplace_xor*/
+ 0, /*nb_inplace_or*/
+ 0, /*nb_floor_divide*/
+ 0, /*nb_true_divide*/
+ 0, /*nb_inplace_floor_divide*/
+ 0, /*nb_inplace_true_divide*/
+ #if PY_VERSION_HEX >= 0x02050000
+ 0, /*nb_index*/
+ #endif
+};
+
+static PySequenceMethods __pyx_tp_as_sequence_asVCFRecord = {
+ 0, /*sq_length*/
+ 0, /*sq_concat*/
+ 0, /*sq_repeat*/
+ 0, /*sq_item*/
+ 0, /*sq_slice*/
+ 0, /*sq_ass_item*/
+ 0, /*sq_ass_slice*/
+ 0, /*sq_contains*/
+ 0, /*sq_inplace_concat*/
+ 0, /*sq_inplace_repeat*/
+};
+
+static PyMappingMethods __pyx_tp_as_mapping_asVCFRecord = {
+ 0, /*mp_length*/
+ 0, /*mp_subscript*/
+ 0, /*mp_ass_subscript*/
+};
+
+static PyBufferProcs __pyx_tp_as_buffer_asVCFRecord = {
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getreadbuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getwritebuffer*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getsegcount*/
+ #endif
+ #if PY_MAJOR_VERSION < 3
+ 0, /*bf_getcharbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_getbuffer*/
+ #endif
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*bf_releasebuffer*/
+ #endif
+};
+
+PyTypeObject __pyx_type_4cvcf_asVCFRecord = {
+ PyVarObject_HEAD_INIT(0, 0)
+ __Pyx_NAMESTR("cvcf.asVCFRecord"), /*tp_name*/
+ sizeof(struct __pyx_obj_4cvcf_asVCFRecord), /*tp_basicsize*/
+ 0, /*tp_itemsize*/
+ __pyx_tp_dealloc_4cvcf_asVCFRecord, /*tp_dealloc*/
+ 0, /*tp_print*/
+ 0, /*tp_getattr*/
+ 0, /*tp_setattr*/
+ #if PY_MAJOR_VERSION < 3
+ 0, /*tp_compare*/
+ #else
+ 0, /*reserved*/
+ #endif
+ 0, /*tp_repr*/
+ &__pyx_tp_as_number_asVCFRecord, /*tp_as_number*/
+ &__pyx_tp_as_sequence_asVCFRecord, /*tp_as_sequence*/
+ &__pyx_tp_as_mapping_asVCFRecord, /*tp_as_mapping*/
+ 0, /*tp_hash*/
+ __pyx_pf_4cvcf_11asVCFRecord___call__, /*tp_call*/
+ 0, /*tp_str*/
+ 0, /*tp_getattro*/
+ 0, /*tp_setattro*/
+ &__pyx_tp_as_buffer_asVCFRecord, /*tp_as_buffer*/
+ Py_TPFLAGS_DEFAULT|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
+ __Pyx_DOCSTR("converts a :term:`tabix row` into a VCF record."), /*tp_doc*/
+ __pyx_tp_traverse_4cvcf_asVCFRecord, /*tp_traverse*/
+ __pyx_tp_clear_4cvcf_asVCFRecord, /*tp_clear*/
+ 0, /*tp_richcompare*/
+ 0, /*tp_weaklistoffset*/
+ 0, /*tp_iter*/
+ 0, /*tp_iternext*/
+ __pyx_methods_4cvcf_asVCFRecord, /*tp_methods*/
+ 0, /*tp_members*/
+ 0, /*tp_getset*/
+ 0, /*tp_base*/
+ 0, /*tp_dict*/
+ 0, /*tp_descr_get*/
+ 0, /*tp_descr_set*/
+ 0, /*tp_dictoffset*/
+ __pyx_pf_4cvcf_11asVCFRecord___init__, /*tp_init*/
+ 0, /*tp_alloc*/
+ __pyx_tp_new_4cvcf_asVCFRecord, /*tp_new*/
+ 0, /*tp_free*/
+ 0, /*tp_is_gc*/
+ 0, /*tp_bases*/
+ 0, /*tp_mro*/
+ 0, /*tp_cache*/
+ 0, /*tp_subclasses*/
+ 0, /*tp_weaklist*/
+ 0, /*tp_del*/
+ #if PY_VERSION_HEX >= 0x02060000
+ 0, /*tp_version_tag*/
+ #endif
+};
+
+static PyMethodDef __pyx_methods[] = {
+ {__Pyx_NAMESTR("get_sequence"), (PyCFunction)__pyx_pf_4cvcf_get_sequence, METH_VARARGS|METH_KEYWORDS, __Pyx_DOCSTR(0)},
+ {__Pyx_NAMESTR("parse_regions"), (PyCFunction)__pyx_pf_4cvcf_parse_regions, METH_O, __Pyx_DOCSTR(0)},
+ {0, 0, 0, 0}
+};
+
+#if PY_MAJOR_VERSION >= 3
+static struct PyModuleDef __pyx_moduledef = {
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+ #ifdef WITH_THREAD /* Python build with threading support? */
+ PyEval_InitThreads();
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+ __Pyx_GOTREF(__pyx_t_2);
+ __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
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+ __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
+ if (PyObject_SetAttr(__pyx_m, __pyx_n_s____test__, ((PyObject *)__pyx_t_1)) < 0) {__pyx_filename = __pyx_f[0]; __pyx_lineno = 1; __pyx_clineno = __LINE__; goto __pyx_L1_error;}
+ __Pyx_DECREF(((PyObject *)__pyx_t_1)); __pyx_t_1 = 0;
+
+ /* "pysam/ctabix.pxd":2
+ *
+ * cdef extern from "string.h": # <<<<<<<<<<<<<<
+ * ctypedef int size_t
+ * void *memcpy(void *dst,void *src,size_t len)
+ */
+ goto __pyx_L0;
+ __pyx_L1_error:;
+ __Pyx_XDECREF(__pyx_t_1);
+ __Pyx_XDECREF(__pyx_t_2);
+ __Pyx_XDECREF(__pyx_t_3);
+ __Pyx_XDECREF(__pyx_t_4);
+ if (__pyx_m) {
+ __Pyx_AddTraceback("init cvcf");
+ Py_DECREF(__pyx_m); __pyx_m = 0;
+ } else if (!PyErr_Occurred()) {
+ PyErr_SetString(PyExc_ImportError, "init cvcf");
+ }
+ __pyx_L0:;
+ __Pyx_RefNannyFinishContext();
+ #if PY_MAJOR_VERSION < 3
+ return;
+ #else
+ return __pyx_m;
+ #endif
+}
+
+/* Runtime support code */
+
+static PyObject *__Pyx_GetName(PyObject *dict, PyObject *name) {
+ PyObject *result;
+ result = PyObject_GetAttr(dict, name);
+ if (!result)
+ PyErr_SetObject(PyExc_NameError, name);
+ return result;
+}
+
+static void __Pyx_RaiseDoubleKeywordsError(
+ const char* func_name,
+ PyObject* kw_name)
+{
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION >= 3
+ "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
+ #else
+ "%s() got multiple values for keyword argument '%s'", func_name,
+ PyString_AS_STRING(kw_name));
+ #endif
+}
+
+static void __Pyx_RaiseArgtupleInvalid(
+ const char* func_name,
+ int exact,
+ Py_ssize_t num_min,
+ Py_ssize_t num_max,
+ Py_ssize_t num_found)
+{
+ Py_ssize_t num_expected;
+ const char *number, *more_or_less;
+
+ if (num_found < num_min) {
+ num_expected = num_min;
+ more_or_less = "at least";
+ } else {
+ num_expected = num_max;
+ more_or_less = "at most";
+ }
+ if (exact) {
+ more_or_less = "exactly";
+ }
+ number = (num_expected == 1) ? "" : "s";
+ PyErr_Format(PyExc_TypeError,
+ #if PY_VERSION_HEX < 0x02050000
+ "%s() takes %s %d positional argument%s (%d given)",
+ #else
+ "%s() takes %s %zd positional argument%s (%zd given)",
+ #endif
+ func_name, more_or_less, num_expected, number, num_found);
+}
+
+static int __Pyx_ParseOptionalKeywords(
+ PyObject *kwds,
+ PyObject **argnames[],
+ PyObject *kwds2,
+ PyObject *values[],
+ Py_ssize_t num_pos_args,
+ const char* function_name)
+{
+ PyObject *key = 0, *value = 0;
+ Py_ssize_t pos = 0;
+ PyObject*** name;
+ PyObject*** first_kw_arg = argnames + num_pos_args;
+
+ while (PyDict_Next(kwds, &pos, &key, &value)) {
+ name = first_kw_arg;
+ while (*name && (**name != key)) name++;
+ if (*name) {
+ values[name-argnames] = value;
+ } else {
+ #if PY_MAJOR_VERSION < 3
+ if (unlikely(!PyString_CheckExact(key)) && unlikely(!PyString_Check(key))) {
+ #else
+ if (unlikely(!PyUnicode_CheckExact(key)) && unlikely(!PyUnicode_Check(key))) {
+ #endif
+ goto invalid_keyword_type;
+ } else {
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+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) break;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
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+ #endif
+ }
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+ values[name-argnames] = value;
+ } else {
+ /* unexpected keyword found */
+ for (name=argnames; name != first_kw_arg; name++) {
+ if (**name == key) goto arg_passed_twice;
+ #if PY_MAJOR_VERSION >= 3
+ if (PyUnicode_GET_SIZE(**name) == PyUnicode_GET_SIZE(key) &&
+ PyUnicode_Compare(**name, key) == 0) goto arg_passed_twice;
+ #else
+ if (PyString_GET_SIZE(**name) == PyString_GET_SIZE(key) &&
+ _PyString_Eq(**name, key)) goto arg_passed_twice;
+ #endif
+ }
+ if (kwds2) {
+ if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
+ } else {
+ goto invalid_keyword;
+ }
+ }
+ }
+ }
+ }
+ return 0;
+arg_passed_twice:
+ __Pyx_RaiseDoubleKeywordsError(function_name, **name);
+ goto bad;
+invalid_keyword_type:
+ PyErr_Format(PyExc_TypeError,
+ "%s() keywords must be strings", function_name);
+ goto bad;
+invalid_keyword:
+ PyErr_Format(PyExc_TypeError,
+ #if PY_MAJOR_VERSION < 3
+ "%s() got an unexpected keyword argument '%s'",
+ function_name, PyString_AsString(key));
+ #else
+ "%s() got an unexpected keyword argument '%U'",
+ function_name, key);
+ #endif
+bad:
+ return -1;
+}
+
+
+static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb) {
+ PyObject *local_type, *local_value, *local_tb;
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ local_type = tstate->curexc_type;
+ local_value = tstate->curexc_value;
+ local_tb = tstate->curexc_traceback;
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+ PyErr_NormalizeException(&local_type, &local_value, &local_tb);
+ if (unlikely(tstate->curexc_type))
+ goto bad;
+ #if PY_MAJOR_VERSION >= 3
+ if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
+ goto bad;
+ #endif
+ *type = local_type;
+ *value = local_value;
+ *tb = local_tb;
+ Py_INCREF(local_type);
+ Py_INCREF(local_value);
+ Py_INCREF(local_tb);
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = local_type;
+ tstate->exc_value = local_value;
+ tstate->exc_traceback = local_tb;
+ /* Make sure tstate is in a consistent state when we XDECREF
+ these objects (XDECREF may run arbitrary code). */
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+ return 0;
+bad:
+ *type = 0;
+ *value = 0;
+ *tb = 0;
+ Py_XDECREF(local_type);
+ Py_XDECREF(local_value);
+ Py_XDECREF(local_tb);
+ return -1;
+}
+
+
+static double __Pyx__PyObject_AsDouble(PyObject* obj) {
+ PyObject* float_value;
+ if (Py_TYPE(obj)->tp_as_number && Py_TYPE(obj)->tp_as_number->nb_float) {
+ return PyFloat_AsDouble(obj);
+ } else if (PyUnicode_CheckExact(obj) || PyBytes_CheckExact(obj)) {
+#if PY_MAJOR_VERSION >= 3
+ float_value = PyFloat_FromString(obj);
+#else
+ float_value = PyFloat_FromString(obj, 0);
+#endif
+ } else {
+ PyObject* args = PyTuple_New(1);
+ if (unlikely(!args)) goto bad;
+ PyTuple_SET_ITEM(args, 0, obj);
+ float_value = PyObject_Call((PyObject*)&PyFloat_Type, args, 0);
+ PyTuple_SET_ITEM(args, 0, 0);
+ Py_DECREF(args);
+ }
+ if (likely(float_value)) {
+ double value = PyFloat_AS_DOUBLE(float_value);
+ Py_DECREF(float_value);
+ return value;
+ }
+bad:
+ return (double)-1;
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNoneIndexingError(void) {
+ PyErr_SetString(PyExc_TypeError, "'NoneType' object is unsubscriptable");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
+ PyErr_Format(PyExc_ValueError,
+ #if PY_VERSION_HEX < 0x02050000
+ "need more than %d value%s to unpack", (int)index,
+ #else
+ "need more than %zd value%s to unpack", index,
+ #endif
+ (index == 1) ? "" : "s");
+}
+
+static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
+ PyErr_Format(PyExc_ValueError,
+ #if PY_VERSION_HEX < 0x02050000
+ "too many values to unpack (expected %d)", (int)expected);
+ #else
+ "too many values to unpack (expected %zd)", expected);
+ #endif
+}
+
+static PyObject *__Pyx_UnpackItem(PyObject *iter, Py_ssize_t index) {
+ PyObject *item;
+ if (!(item = PyIter_Next(iter))) {
+ if (!PyErr_Occurred()) {
+ __Pyx_RaiseNeedMoreValuesError(index);
+ }
+ }
+ return item;
+}
+
+static int __Pyx_EndUnpack(PyObject *iter, Py_ssize_t expected) {
+ PyObject *item;
+ if ((item = PyIter_Next(iter))) {
+ Py_DECREF(item);
+ __Pyx_RaiseTooManyValuesError(expected);
+ return -1;
+ }
+ else if (!PyErr_Occurred())
+ return 0;
+ else
+ return -1;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t a, Py_ssize_t b) {
+ Py_ssize_t q = a / b;
+ Py_ssize_t r = a - q*b;
+ q -= ((r != 0) & ((r ^ b) < 0));
+ return q;
+}
+
+
+static CYTHON_INLINE void __Pyx_ExceptionSave(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->exc_type;
+ *value = tstate->exc_value;
+ *tb = tstate->exc_traceback;
+ Py_XINCREF(*type);
+ Py_XINCREF(*value);
+ Py_XINCREF(*tb);
+}
+
+static void __Pyx_ExceptionReset(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+ tmp_type = tstate->exc_type;
+ tmp_value = tstate->exc_value;
+ tmp_tb = tstate->exc_traceback;
+ tstate->exc_type = type;
+ tstate->exc_value = value;
+ tstate->exc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list) {
+ PyObject *py_import = 0;
+ PyObject *empty_list = 0;
+ PyObject *module = 0;
+ PyObject *global_dict = 0;
+ PyObject *empty_dict = 0;
+ PyObject *list;
+ py_import = __Pyx_GetAttrString(__pyx_b, "__import__");
+ if (!py_import)
+ goto bad;
+ if (from_list)
+ list = from_list;
+ else {
+ empty_list = PyList_New(0);
+ if (!empty_list)
+ goto bad;
+ list = empty_list;
+ }
+ global_dict = PyModule_GetDict(__pyx_m);
+ if (!global_dict)
+ goto bad;
+ empty_dict = PyDict_New();
+ if (!empty_dict)
+ goto bad;
+ module = PyObject_CallFunctionObjArgs(py_import,
+ name, global_dict, empty_dict, list, NULL);
+bad:
+ Py_XDECREF(empty_list);
+ Py_XDECREF(py_import);
+ Py_XDECREF(empty_dict);
+ return module;
+}
+
+static PyObject *__Pyx_CreateClass(
+ PyObject *bases, PyObject *dict, PyObject *name, const char *modname)
+{
+ PyObject *py_modname;
+ PyObject *result = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_modname = PyString_FromString(modname);
+ #else
+ py_modname = PyUnicode_FromString(modname);
+ #endif
+ if (!py_modname)
+ goto bad;
+ if (PyDict_SetItemString(dict, "__module__", py_modname) < 0)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ result = PyClass_New(bases, dict, name);
+ #else
+ result = PyObject_CallFunctionObjArgs((PyObject *)&PyType_Type, name, bases, dict, NULL);
+ #endif
+bad:
+ Py_XDECREF(py_modname);
+ return result;
+}
+
+static CYTHON_INLINE void __Pyx_ErrRestore(PyObject *type, PyObject *value, PyObject *tb) {
+ PyObject *tmp_type, *tmp_value, *tmp_tb;
+ PyThreadState *tstate = PyThreadState_GET();
+
+ tmp_type = tstate->curexc_type;
+ tmp_value = tstate->curexc_value;
+ tmp_tb = tstate->curexc_traceback;
+ tstate->curexc_type = type;
+ tstate->curexc_value = value;
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_type);
+ Py_XDECREF(tmp_value);
+ Py_XDECREF(tmp_tb);
+}
+
+static CYTHON_INLINE void __Pyx_ErrFetch(PyObject **type, PyObject **value, PyObject **tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ *type = tstate->curexc_type;
+ *value = tstate->curexc_value;
+ *tb = tstate->curexc_traceback;
+
+ tstate->curexc_type = 0;
+ tstate->curexc_value = 0;
+ tstate->curexc_traceback = 0;
+}
+
+
+#if PY_MAJOR_VERSION < 3
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ Py_XINCREF(type);
+ Py_XINCREF(value);
+ Py_XINCREF(tb);
+ /* First, check the traceback argument, replacing None with NULL. */
+ if (tb == Py_None) {
+ Py_DECREF(tb);
+ tb = 0;
+ }
+ else if (tb != NULL && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto raise_error;
+ }
+ /* Next, replace a missing value with None */
+ if (value == NULL) {
+ value = Py_None;
+ Py_INCREF(value);
+ }
+ #if PY_VERSION_HEX < 0x02050000
+ if (!PyClass_Check(type))
+ #else
+ if (!PyType_Check(type))
+ #endif
+ {
+ /* Raising an instance. The value should be a dummy. */
+ if (value != Py_None) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto raise_error;
+ }
+ /* Normalize to raise <class>, <instance> */
+ Py_DECREF(value);
+ value = type;
+ #if PY_VERSION_HEX < 0x02050000
+ if (PyInstance_Check(type)) {
+ type = (PyObject*) ((PyInstanceObject*)type)->in_class;
+ Py_INCREF(type);
+ }
+ else {
+ type = 0;
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception must be an old-style class or instance");
+ goto raise_error;
+ }
+ #else
+ type = (PyObject*) Py_TYPE(type);
+ Py_INCREF(type);
+ if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto raise_error;
+ }
+ #endif
+ }
+
+ __Pyx_ErrRestore(type, value, tb);
+ return;
+raise_error:
+ Py_XDECREF(value);
+ Py_XDECREF(type);
+ Py_XDECREF(tb);
+ return;
+}
+
+#else /* Python 3+ */
+
+static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb) {
+ if (tb == Py_None) {
+ tb = 0;
+ } else if (tb && !PyTraceBack_Check(tb)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: arg 3 must be a traceback or None");
+ goto bad;
+ }
+ if (value == Py_None)
+ value = 0;
+
+ if (PyExceptionInstance_Check(type)) {
+ if (value) {
+ PyErr_SetString(PyExc_TypeError,
+ "instance exception may not have a separate value");
+ goto bad;
+ }
+ value = type;
+ type = (PyObject*) Py_TYPE(value);
+ } else if (!PyExceptionClass_Check(type)) {
+ PyErr_SetString(PyExc_TypeError,
+ "raise: exception class must be a subclass of BaseException");
+ goto bad;
+ }
+
+ PyErr_SetObject(type, value);
+
+ if (tb) {
+ PyThreadState *tstate = PyThreadState_GET();
+ PyObject* tmp_tb = tstate->curexc_traceback;
+ if (tb != tmp_tb) {
+ Py_INCREF(tb);
+ tstate->curexc_traceback = tb;
+ Py_XDECREF(tmp_tb);
+ }
+ }
+
+bad:
+ return;
+}
+#endif
+
+static CYTHON_INLINE PyObject *__Pyx_PyInt_to_py_uint32_t(uint32_t val) {
+ const uint32_t neg_one = (uint32_t)-1, const_zero = (uint32_t)0;
+ const int is_unsigned = const_zero < neg_one;
+ if ((sizeof(uint32_t) == sizeof(char)) ||
+ (sizeof(uint32_t) == sizeof(short))) {
+ return PyInt_FromLong((long)val);
+ } else if ((sizeof(uint32_t) == sizeof(int)) ||
+ (sizeof(uint32_t) == sizeof(long))) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLong((unsigned long)val);
+ else
+ return PyInt_FromLong((long)val);
+ } else if (sizeof(uint32_t) == sizeof(PY_LONG_LONG)) {
+ if (is_unsigned)
+ return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG)val);
+ else
+ return PyLong_FromLongLong((PY_LONG_LONG)val);
+ } else {
+ int one = 1; int little = (int)*(unsigned char *)&one;
+ unsigned char *bytes = (unsigned char *)&val;
+ return _PyLong_FromByteArray(bytes, sizeof(uint32_t),
+ little, !is_unsigned);
+ }
+}
+
+static CYTHON_INLINE unsigned char __Pyx_PyInt_AsUnsignedChar(PyObject* x) {
+ const unsigned char neg_one = (unsigned char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned char" :
+ "value too large to convert to unsigned char");
+ }
+ return (unsigned char)-1;
+ }
+ return (unsigned char)val;
+ }
+ return (unsigned char)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned short __Pyx_PyInt_AsUnsignedShort(PyObject* x) {
+ const unsigned short neg_one = (unsigned short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned short" :
+ "value too large to convert to unsigned short");
+ }
+ return (unsigned short)-1;
+ }
+ return (unsigned short)val;
+ }
+ return (unsigned short)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE unsigned int __Pyx_PyInt_AsUnsignedInt(PyObject* x) {
+ const unsigned int neg_one = (unsigned int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(unsigned int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(unsigned int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to unsigned int" :
+ "value too large to convert to unsigned int");
+ }
+ return (unsigned int)-1;
+ }
+ return (unsigned int)val;
+ }
+ return (unsigned int)__Pyx_PyInt_AsUnsignedLong(x);
+}
+
+static CYTHON_INLINE char __Pyx_PyInt_AsChar(PyObject* x) {
+ const char neg_one = (char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to char" :
+ "value too large to convert to char");
+ }
+ return (char)-1;
+ }
+ return (char)val;
+ }
+ return (char)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE short __Pyx_PyInt_AsShort(PyObject* x) {
+ const short neg_one = (short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to short" :
+ "value too large to convert to short");
+ }
+ return (short)-1;
+ }
+ return (short)val;
+ }
+ return (short)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsInt(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE signed char __Pyx_PyInt_AsSignedChar(PyObject* x) {
+ const signed char neg_one = (signed char)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed char) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed char)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed char" :
+ "value too large to convert to signed char");
+ }
+ return (signed char)-1;
+ }
+ return (signed char)val;
+ }
+ return (signed char)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed short __Pyx_PyInt_AsSignedShort(PyObject* x) {
+ const signed short neg_one = (signed short)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed short) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed short)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed short" :
+ "value too large to convert to signed short");
+ }
+ return (signed short)-1;
+ }
+ return (signed short)val;
+ }
+ return (signed short)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE signed int __Pyx_PyInt_AsSignedInt(PyObject* x) {
+ const signed int neg_one = (signed int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(signed int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(signed int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to signed int" :
+ "value too large to convert to signed int");
+ }
+ return (signed int)-1;
+ }
+ return (signed int)val;
+ }
+ return (signed int)__Pyx_PyInt_AsSignedLong(x);
+}
+
+static CYTHON_INLINE int __Pyx_PyInt_AsLongDouble(PyObject* x) {
+ const int neg_one = (int)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+ if (sizeof(int) < sizeof(long)) {
+ long val = __Pyx_PyInt_AsLong(x);
+ if (unlikely(val != (long)(int)val)) {
+ if (!unlikely(val == -1 && PyErr_Occurred())) {
+ PyErr_SetString(PyExc_OverflowError,
+ (is_unsigned && unlikely(val < 0)) ?
+ "can't convert negative value to int" :
+ "value too large to convert to int");
+ }
+ return (int)-1;
+ }
+ return (int)val;
+ }
+ return (int)__Pyx_PyInt_AsLong(x);
+}
+
+static CYTHON_INLINE unsigned long __Pyx_PyInt_AsUnsignedLong(PyObject* x) {
+ const unsigned long neg_one = (unsigned long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return (unsigned long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned long");
+ return (unsigned long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ unsigned long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned long)-1;
+ val = __Pyx_PyInt_AsUnsignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE unsigned PY_LONG_LONG __Pyx_PyInt_AsUnsignedLongLong(PyObject* x) {
+ const unsigned PY_LONG_LONG neg_one = (unsigned PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return (unsigned PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to unsigned PY_LONG_LONG");
+ return (unsigned PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ unsigned PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (unsigned PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsUnsignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE long __Pyx_PyInt_AsLong(PyObject* x) {
+ const long neg_one = (long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return (long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to long");
+ return (long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (long)-1;
+ val = __Pyx_PyInt_AsLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE PY_LONG_LONG __Pyx_PyInt_AsLongLong(PyObject* x) {
+ const PY_LONG_LONG neg_one = (PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return (PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to PY_LONG_LONG");
+ return (PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed long __Pyx_PyInt_AsSignedLong(PyObject* x) {
+ const signed long neg_one = (signed long)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return (signed long)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed long");
+ return (signed long)-1;
+ }
+ return PyLong_AsUnsignedLong(x);
+ } else {
+ return PyLong_AsLong(x);
+ }
+ } else {
+ signed long val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed long)-1;
+ val = __Pyx_PyInt_AsSignedLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+static CYTHON_INLINE signed PY_LONG_LONG __Pyx_PyInt_AsSignedLongLong(PyObject* x) {
+ const signed PY_LONG_LONG neg_one = (signed PY_LONG_LONG)-1, const_zero = 0;
+ const int is_unsigned = neg_one > const_zero;
+#if PY_VERSION_HEX < 0x03000000
+ if (likely(PyInt_Check(x))) {
+ long val = PyInt_AS_LONG(x);
+ if (is_unsigned && unlikely(val < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return (signed PY_LONG_LONG)val;
+ } else
+#endif
+ if (likely(PyLong_Check(x))) {
+ if (is_unsigned) {
+ if (unlikely(Py_SIZE(x) < 0)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "can't convert negative value to signed PY_LONG_LONG");
+ return (signed PY_LONG_LONG)-1;
+ }
+ return PyLong_AsUnsignedLongLong(x);
+ } else {
+ return PyLong_AsLongLong(x);
+ }
+ } else {
+ signed PY_LONG_LONG val;
+ PyObject *tmp = __Pyx_PyNumber_Int(x);
+ if (!tmp) return (signed PY_LONG_LONG)-1;
+ val = __Pyx_PyInt_AsSignedLongLong(tmp);
+ Py_DECREF(tmp);
+ return val;
+ }
+}
+
+#ifndef __PYX_HAVE_RT_ImportType
+#define __PYX_HAVE_RT_ImportType
+static PyTypeObject *__Pyx_ImportType(const char *module_name, const char *class_name,
+ long size, int strict)
+{
+ PyObject *py_module = 0;
+ PyObject *result = 0;
+ PyObject *py_name = 0;
+ char warning[200];
+
+ py_module = __Pyx_ImportModule(module_name);
+ if (!py_module)
+ goto bad;
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(class_name);
+ #else
+ py_name = PyUnicode_FromString(class_name);
+ #endif
+ if (!py_name)
+ goto bad;
+ result = PyObject_GetAttr(py_module, py_name);
+ Py_DECREF(py_name);
+ py_name = 0;
+ Py_DECREF(py_module);
+ py_module = 0;
+ if (!result)
+ goto bad;
+ if (!PyType_Check(result)) {
+ PyErr_Format(PyExc_TypeError,
+ "%s.%s is not a type object",
+ module_name, class_name);
+ goto bad;
+ }
+ if (!strict && ((PyTypeObject *)result)->tp_basicsize > size) {
+ PyOS_snprintf(warning, sizeof(warning),
+ "%s.%s size changed, may indicate binary incompatibility",
+ module_name, class_name);
+ #if PY_VERSION_HEX < 0x02050000
+ PyErr_Warn(NULL, warning);
+ #else
+ PyErr_WarnEx(NULL, warning, 0);
+ #endif
+ }
+ else if (((PyTypeObject *)result)->tp_basicsize != size) {
+ PyErr_Format(PyExc_ValueError,
+ "%s.%s has the wrong size, try recompiling",
+ module_name, class_name);
+ goto bad;
+ }
+ return (PyTypeObject *)result;
+bad:
+ Py_XDECREF(py_module);
+ Py_XDECREF(result);
+ return 0;
+}
+#endif
+
+#ifndef __PYX_HAVE_RT_ImportModule
+#define __PYX_HAVE_RT_ImportModule
+static PyObject *__Pyx_ImportModule(const char *name) {
+ PyObject *py_name = 0;
+ PyObject *py_module = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_name = PyString_FromString(name);
+ #else
+ py_name = PyUnicode_FromString(name);
+ #endif
+ if (!py_name)
+ goto bad;
+ py_module = PyImport_Import(py_name);
+ Py_DECREF(py_name);
+ return py_module;
+bad:
+ Py_XDECREF(py_name);
+ return 0;
+}
+#endif
+
+static int __Pyx_GetVtable(PyObject *dict, void *vtabptr) {
+ PyObject *ob = PyMapping_GetItemString(dict, (char *)"__pyx_vtable__");
+ if (!ob)
+ goto bad;
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+ *(void **)vtabptr = PyCapsule_GetPointer(ob, 0);
+#else
+ *(void **)vtabptr = PyCObject_AsVoidPtr(ob);
+#endif
+ if (!*(void **)vtabptr)
+ goto bad;
+ Py_DECREF(ob);
+ return 0;
+bad:
+ Py_XDECREF(ob);
+ return -1;
+}
+
+static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
+#if PY_VERSION_HEX >= 0x02070000 && !(PY_MAJOR_VERSION==3&&PY_MINOR_VERSION==0)
+ PyObject *ob = PyCapsule_New(vtable, 0, 0);
+#else
+ PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
+#endif
+ if (!ob)
+ goto bad;
+ if (PyDict_SetItemString(dict, "__pyx_vtable__", ob) < 0)
+ goto bad;
+ Py_DECREF(ob);
+ return 0;
+bad:
+ Py_XDECREF(ob);
+ return -1;
+}
+
+#include "compile.h"
+#include "frameobject.h"
+#include "traceback.h"
+
+static void __Pyx_AddTraceback(const char *funcname) {
+ PyObject *py_srcfile = 0;
+ PyObject *py_funcname = 0;
+ PyObject *py_globals = 0;
+ PyCodeObject *py_code = 0;
+ PyFrameObject *py_frame = 0;
+
+ #if PY_MAJOR_VERSION < 3
+ py_srcfile = PyString_FromString(__pyx_filename);
+ #else
+ py_srcfile = PyUnicode_FromString(__pyx_filename);
+ #endif
+ if (!py_srcfile) goto bad;
+ if (__pyx_clineno) {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #else
+ py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, __pyx_clineno);
+ #endif
+ }
+ else {
+ #if PY_MAJOR_VERSION < 3
+ py_funcname = PyString_FromString(funcname);
+ #else
+ py_funcname = PyUnicode_FromString(funcname);
+ #endif
+ }
+ if (!py_funcname) goto bad;
+ py_globals = PyModule_GetDict(__pyx_m);
+ if (!py_globals) goto bad;
+ py_code = PyCode_New(
+ 0, /*int argcount,*/
+ #if PY_MAJOR_VERSION >= 3
+ 0, /*int kwonlyargcount,*/
+ #endif
+ 0, /*int nlocals,*/
+ 0, /*int stacksize,*/
+ 0, /*int flags,*/
+ __pyx_empty_bytes, /*PyObject *code,*/
+ __pyx_empty_tuple, /*PyObject *consts,*/
+ __pyx_empty_tuple, /*PyObject *names,*/
+ __pyx_empty_tuple, /*PyObject *varnames,*/
+ __pyx_empty_tuple, /*PyObject *freevars,*/
+ __pyx_empty_tuple, /*PyObject *cellvars,*/
+ py_srcfile, /*PyObject *filename,*/
+ py_funcname, /*PyObject *name,*/
+ __pyx_lineno, /*int firstlineno,*/
+ __pyx_empty_bytes /*PyObject *lnotab*/
+ );
+ if (!py_code) goto bad;
+ py_frame = PyFrame_New(
+ PyThreadState_GET(), /*PyThreadState *tstate,*/
+ py_code, /*PyCodeObject *code,*/
+ py_globals, /*PyObject *globals,*/
+ 0 /*PyObject *locals*/
+ );
+ if (!py_frame) goto bad;
+ py_frame->f_lineno = __pyx_lineno;
+ PyTraceBack_Here(py_frame);
+bad:
+ Py_XDECREF(py_srcfile);
+ Py_XDECREF(py_funcname);
+ Py_XDECREF(py_code);
+ Py_XDECREF(py_frame);
+}
+
+static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
+ while (t->p) {
+ #if PY_MAJOR_VERSION < 3
+ if (t->is_unicode) {
+ *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
+ } else if (t->intern) {
+ *t->p = PyString_InternFromString(t->s);
+ } else {
+ *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
+ }
+ #else /* Python 3+ has unicode identifiers */
+ if (t->is_unicode | t->is_str) {
+ if (t->intern) {
+ *t->p = PyUnicode_InternFromString(t->s);
+ } else if (t->encoding) {
+ *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
+ } else {
+ *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
+ }
+ } else {
+ *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
+ }
+ #endif
+ if (!*t->p)
+ return -1;
+ ++t;
+ }
+ return 0;
+}
+
+/* Type Conversion Functions */
+
+static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
+ int is_true = x == Py_True;
+ if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
+ else return PyObject_IsTrue(x);
+}
+
+static CYTHON_INLINE PyObject* __Pyx_PyNumber_Int(PyObject* x) {
+ PyNumberMethods *m;
+ const char *name = NULL;
+ PyObject *res = NULL;
+#if PY_VERSION_HEX < 0x03000000
+ if (PyInt_Check(x) || PyLong_Check(x))
+#else
+ if (PyLong_Check(x))
+#endif
+ return Py_INCREF(x), x;
+ m = Py_TYPE(x)->tp_as_number;
+#if PY_VERSION_HEX < 0x03000000
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Int(x);
+ }
+ else if (m && m->nb_long) {
+ name = "long";
+ res = PyNumber_Long(x);
+ }
+#else
+ if (m && m->nb_int) {
+ name = "int";
+ res = PyNumber_Long(x);
+ }
+#endif
+ if (res) {
+#if PY_VERSION_HEX < 0x03000000
+ if (!PyInt_Check(res) && !PyLong_Check(res)) {
+#else
+ if (!PyLong_Check(res)) {
+#endif
+ PyErr_Format(PyExc_TypeError,
+ "__%s__ returned non-%s (type %.200s)",
+ name, name, Py_TYPE(res)->tp_name);
+ Py_DECREF(res);
+ return NULL;
+ }
+ }
+ else if (!PyErr_Occurred()) {
+ PyErr_SetString(PyExc_TypeError,
+ "an integer is required");
+ }
+ return res;
+}
+
+static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
+ Py_ssize_t ival;
+ PyObject* x = PyNumber_Index(b);
+ if (!x) return -1;
+ ival = PyInt_AsSsize_t(x);
+ Py_DECREF(x);
+ return ival;
+}
+
+static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
+#if PY_VERSION_HEX < 0x02050000
+ if (ival <= LONG_MAX)
+ return PyInt_FromLong((long)ival);
+ else {
+ unsigned char *bytes = (unsigned char *) &ival;
+ int one = 1; int little = (int)*(unsigned char*)&one;
+ return _PyLong_FromByteArray(bytes, sizeof(size_t), little, 0);
+ }
+#else
+ return PyInt_FromSize_t(ival);
+#endif
+}
+
+static CYTHON_INLINE size_t __Pyx_PyInt_AsSize_t(PyObject* x) {
+ unsigned PY_LONG_LONG val = __Pyx_PyInt_AsUnsignedLongLong(x);
+ if (unlikely(val == (unsigned PY_LONG_LONG)-1 && PyErr_Occurred())) {
+ return (size_t)-1;
+ } else if (unlikely(val != (unsigned PY_LONG_LONG)(size_t)val)) {
+ PyErr_SetString(PyExc_OverflowError,
+ "value too large to convert to size_t");
+ return (size_t)-1;
+ }
+ return (size_t)val;
+}
+
+
+#endif /* Py_PYTHON_H */
--- /dev/null
+cdef extern from "stdlib.h":
+ void free(void *)
+ void *malloc(size_t)
+ void *calloc(size_t,size_t)
+ void *realloc(void *,size_t)
+ int c_abs "abs" (int)
+ int c_abs "abs" (int)
+ int atoi( char *nptr)
+ long atol( char *nptr)
+ double atof( char *nptr)
+
+cdef extern from "Python.h":
+ ctypedef struct FILE
+ FILE* PyFile_AsFile(object)
+ char *fgets(char *str, int size, FILE *ifile)
+ int feof(FILE *stream)
+ size_t strlen(char *s)
+ size_t getline(char **lineptr, size_t *n, FILE *stream)
+ char *strstr(char *, char *)
+ char *strchr(char *string, int c)
+ int fileno(FILE *stream)
+
+cdef extern from "string.h":
+ int strcmp(char *s1, char *s2)
+ int strncmp(char *s1,char *s2,size_t len)
+ char *strcpy(char *dest,char *src)
+ char *strncpy(char *dest,char *src, size_t len)
+ char *strdup(char *)
+ char *strcat(char *,char *)
+ size_t strlen(char *s)
+ int memcmp( void * s1, void *s2, size_t len )
+ void *memcpy(void *dest, void *src, size_t n)
+ void *memchr(void *s, int c, size_t n)
+
+cdef extern from "stdint.h":
+ ctypedef int int64_t
+ ctypedef int int32_t
+ ctypedef int uint32_t
+ ctypedef int uint8_t
+ ctypedef int uint64_t
+
--- /dev/null
+#
+# Code to read, write and edit VCF files
+#
+# VCF lines are encoded as a dictionary with these keys (note: all lowercase):
+# 'chrom': string
+# 'pos': integer
+# 'id': string
+# 'ref': string
+# 'alt': list of strings
+# 'qual': integer
+# 'filter': None (missing value), or list of keys (strings); empty list parsed as ["PASS"]
+# 'info': dictionary of values (see below)
+# 'format': list of keys (strings)
+# sample keys: dictionary of values (see below)
+#
+# The sample keys are accessible through vcf.getsamples()
+#
+# A dictionary of values contains value keys (defined in ##INFO or ##FORMAT lines) which map
+# to a list, containign integers, floats, strings, or characters. Missing values are replaced
+# by a particular value, often -1 or .
+#
+# Genotypes are not stored as a string, but as a list of 1 or 3 elements (for haploid and diploid samples),
+# the first (and last) the integer representing an allele, and the second the separation character.
+# Note that there is just one genotype per sample, but for consistency the single element is stored in a list.
+#
+# Header lines other than ##INFO, ##FORMAT and ##FILTER are stored as (key, value) pairs and are accessible
+# through getheader()
+#
+# The VCF class can be instantiated with a 'regions' variable consisting of tuples (chrom,start,end) encoding
+# 0-based half-open segments. Only variants with a position inside the segment will be parsed. A regions
+# parser is available under parse_regions.
+#
+# When instantiated, a reference can be passed to the VCF class. This may be any class that supports a
+# fetch(chrom, start, end) method.
+#
+#
+#
+# NOTE: the position that is returned to Python is 0-based, NOT 1-based as in the VCF file.
+#
+#
+#
+# TODO:
+# only v4.0 writing is complete; alleles are not converted to v3.3 format
+#
+
+from collections import namedtuple, defaultdict
+from operator import itemgetter
+import sys, re, copy, bisect
+
+cimport ctabix
+cimport TabProxies
+import pysam
+
+gtsRegEx = re.compile("[|/\\\\]")
+alleleRegEx = re.compile('^[ACGTN]+$')
+
+# Utility function. Uses 0-based coordinates
+def get_sequence(chrom, start, end, fa):
+ # obtain sequence from .fa file, without truncation
+ if end<=start: return ""
+ if not fa: return "N"*(end-start)
+ if start<0: return "N"*(-start) + get_sequence(chrom, 0, end, fa).upper()
+ sequence = fa.fetch(chrom, start, end).upper()
+ if len(sequence) < end-start: sequence += "N"*(end-start-len(sequence))
+ return sequence
+
+# Utility function. Parses a region string
+def parse_regions( string ):
+ result = []
+ for r in string.split(','):
+ elts = r.split(':')
+ chrom, start, end = elts[0], 0, 3000000000
+ if len(elts)==1: pass
+ elif len(elts)==2:
+ if len(elts[1])>0:
+ ielts = elts[1].split('-')
+ if len(ielts) != 2: ValueError("Don't understand region string '%s'" % r)
+ try: start, end = int(ielts[0])-1, int(ielts[1])
+ except: raise ValueError("Don't understand region string '%s'" % r)
+ else:
+ raise ValueError("Don't understand region string '%s'" % r)
+ result.append( (chrom,start,end) )
+ return result
+
+
+FORMAT = namedtuple('FORMAT','id numbertype number type description missingvalue')
+
+###########################################################################################################
+#
+# New class
+#
+###########################################################################################################
+
+cdef class VCFRecord( TabProxies.TupleProxy):
+ '''vcf record.
+
+ initialized from data and vcf meta
+ '''
+
+ cdef vcf
+ cdef char * contig
+ cdef uint32_t pos
+
+ def __init__(self, vcf):
+ self.vcf = vcf
+ # if len(data) != len(self.vcf._samples):
+ # self.error(str(data),
+ # self.BAD_NUMBER_OF_COLUMNS,
+ # "expected %s for %s samples (%s), got %s" % \
+ # (len(self.vcf._samples),
+ # len(self.vcf._samples),
+ # self.vcf._samples,
+ # len(data)))
+
+ def __cinit__(self, vcf ):
+ # start indexed access at genotypes
+ self.offset = 9
+
+ self.vcf = vcf
+
+ cdef update( self, char * buffer, size_t nbytes ):
+ '''update internal data.
+
+ nbytes does not include the terminal '\0'.
+ '''
+ TabProxies.TupleProxy.update( self, buffer, nbytes )
+
+ self.contig = self.fields[0]
+ # vcf counts from 1 - correct here
+ self.pos = atoi( self.fields[1] ) - 1
+
+ def __len__(self):
+ return max(0, self.nfields - 9)
+
+ property contig:
+ def __get__(self): return self.contig
+
+ property pos:
+ def __get__(self): return self.pos
+
+ property id:
+ def __get__(self): return self.fields[2]
+
+ property ref:
+ def __get__(self): return self.fields[3]
+
+ property alt:
+ def __get__(self):
+ # convert v3.3 to v4.0 alleles below
+ alt = self.fields[4]
+ if alt == ".": alt = []
+ else: alt = alt.upper().split(',')
+ return alt
+
+ property qual:
+ def __get__(self):
+ qual = self.fields[5]
+ if qual == b".": qual = -1
+ else:
+ try: qual = float(qual)
+ except: self.vcf.error(str(self),self.QUAL_NOT_NUMERICAL)
+
+ property filter:
+ def __get__(self):
+ f = self.fields[6]
+ # postpone checking that filters exist. Encode missing filter or no filtering as empty list
+ if f == b"." or f == b"PASS" or f == b"0": return []
+ else: return f.split(';')
+
+ property info:
+ def __get__(self):
+ col = self.fields[7]
+ # dictionary of keys, and list of values
+ info = {}
+ if col != b".":
+ for blurp in col.split(';'):
+ elts = blurp.split('=')
+ if len(elts) == 1: v = None
+ elif len(elts) == 2: v = elts[1]
+ else: self.vcf.error(str(self),self.ERROR_INFO_STRING)
+ info[elts[0]] = self.vcf.parse_formatdata(elts[0], v, self.vcf._info, str(self))
+ return info
+
+ property format:
+ def __get__(self):
+ return self.fields[8].split(':')
+
+ property samples:
+ def __get__(self):
+ return self.vcf._samples
+
+ def __getitem__(self, key):
+
+ # parse sample columns
+ values = self.fields[self.vcf._sample2column[key]].split(':')
+ alt = self.alt
+ format = self.format
+
+ if len(values) > len(format):
+ self.error(str(self.line),self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" %\
+ (len(values),key,len(format)))
+
+ result = {}
+ for idx in range(len(format)):
+ expected = self.vcf.get_expected(format[idx], self.vcf._format, alt)
+ if idx < len(values): value = values[idx]
+ else:
+ if expected == -1: value = "."
+ else: value = ",".join(["."]*expected)
+
+ result[format[idx]] = self.vcf.parse_formatdata(format[idx], value, self.vcf._format, str(self.data))
+ if expected != -1 and len(result[format[idx]]) != expected:
+ self.error(str(self.data),self.BAD_NUMBER_OF_PARAMETERS,
+ "id=%s, expected %s parameters, got %s" % (format[idx],expected,result[format[idx]]))
+ if len(result[format[idx]] ) < expected: result[format[idx]] += [result[format[idx]][-1]]*(expected-len(result[format[idx]]))
+ result[format[idx]] = result[format[idx]][:expected]
+
+ return result
+
+
+cdef class asVCFRecord( ctabix.Parser ):
+ '''converts a :term:`tabix row` into a VCF record.'''
+ cdef vcffile
+ def __init__(self, vcffile ):
+ self.vcffile = vcffile
+ def __call__(self, char * buffer, int len ):
+ cdef VCFRecord r
+ r = VCFRecord( self.vcffile )
+ r.copy( buffer, len )
+ return r
+
+class VCF(object):
+
+ # types
+ NT_UNKNOWN = 0
+ NT_NUMBER = 1
+ NT_ALLELES = 2
+ NT_NR_ALLELES = 3
+ NT_GENOTYPES = 4
+ NT_PHASED_GENOTYPES = 5
+
+ _errors = { 0:"UNKNOWN_FORMAT_STRING:Unknown file format identifier",
+ 1:"BADLY_FORMATTED_FORMAT_STRING:Formatting error in the format string",
+ 2:"BADLY_FORMATTED_HEADING:Did not find 9 required headings (CHROM, POS, ..., FORMAT) %s",
+ 3:"BAD_NUMBER_OF_COLUMNS:Wrong number of columns found (%s)",
+ 4:"POS_NOT_NUMERICAL:Position column is not numerical",
+ 5:"UNKNOWN_CHAR_IN_REF:Unknown character in reference field",
+ 6:"V33_BAD_REF:Reference should be single-character in v3.3 VCF",
+ 7:"V33_BAD_ALLELE:Cannot interpret allele for v3.3 VCF",
+ 8:"POS_NOT_POSITIVE:Position field must be >0",
+ 9:"QUAL_NOT_NUMERICAL:Quality field must be numerical, or '.'",
+ 10:"ERROR_INFO_STRING:Error while parsing info field",
+ 11:"ERROR_UNKNOWN_KEY:Unknown key (%s) found in formatted field (info; format; or filter)",
+ 12:"ERROR_FORMAT_NOT_NUMERICAL:Expected integer or float in formatted field; got %s",
+ 13:"ERROR_FORMAT_NOT_CHAR:Eexpected character in formatted field; got string",
+ 14:"FILTER_NOT_DEFINED:Identifier (%s) in filter found which was not defined in header",
+ 15:"FORMAT_NOT_DEFINED:Identifier (%s) in format found which was not defined in header",
+ 16:"BAD_NUMBER_OF_VALUES:Found too many of values in sample column (%s)",
+ 17:"BAD_NUMBER_OF_PARAMETERS:Found unexpected number of parameters (%s)",
+ 18:"BAD_GENOTYPE:Cannot parse genotype (%s)",
+ 19:"V40_BAD_ALLELE:Bad allele found for v4.0 VCF (%s)",
+ 20:"MISSING_REF:Reference allele missing",
+ 21:"V33_UNMATCHED_DELETION:Deleted sequence does not match reference (%s)",
+ 22:"V40_MISSING_ANGLE_BRACKETS:Format definition is not deliminted by angular brackets",
+ 23:"FORMAT_MISSING_QUOTES:Description field in format definition is not surrounded by quotes",
+ 24:"V40_FORMAT_MUST_HAVE_NAMED_FIELDS:Fields in v4.0 VCF format definition must have named fields",
+ 25:"HEADING_NOT_SEPARATED_BY_TABS:Heading line appears separated by spaces, not tabs",
+ 26:"WRONG_REF:Wrong reference %s",
+ 27:"ERROR_TRAILING_DATA:Numerical field ('%s') has semicolon-separated trailing data",
+ 28:"BAD_CHR_TAG:Error calculating chr tag for %s",
+ 29:"ZERO_LENGTH_ALLELE:Found zero-length allele",
+ 30:"MISSING_INDEL_ALLELE_REF_BASE:Indel alleles must begin with single reference base"
+ }
+
+ # tag-value pairs; tags are not unique; does not include fileformat, INFO, FILTER or FORMAT fields
+ _header = []
+
+ # version number; 33=v3.3; 40=v4.0
+ _version = 40
+
+ # info, filter and format data
+ _info = {}
+ _filter = {}
+ _format = {}
+
+ # header; and required columns
+ _required = ["CHROM","POS","ID","REF","ALT","QUAL","FILTER","INFO","FORMAT"]
+ _samples = []
+
+ # control behaviour
+ _ignored_errors = set([11]) # ERROR_UNKNOWN_KEY
+ _warn_errors = set([])
+ _leftalign = False
+
+ # reference sequence
+ _reference = None
+
+ # regions to include; None includes everything
+ _regions = None
+
+ # statefull stuff
+ _lineno = -1
+ _line = None
+ _lines = None
+
+ def __init__(self, _copy=None, reference=None, regions=None, lines=None, leftalign=False):
+ # make error identifiers accessible by name
+ for id in self._errors.keys(): self.__dict__[self._errors[id].split(':')[0]] = id
+ if _copy != None:
+ self._leftalign = _copy._leftalign
+ self._header = _copy._header[:]
+ self._version = _copy._version
+ self._info = copy.deepcopy(_copy._info)
+ self._filter = copy.deepcopy(_copy._filter)
+ self._format = copy.deepcopy(_copy._format)
+ self._samples = _copy._samples[:]
+ self._sample2column = copy.deepcopy(_copy._sample2column)
+ self._ignored_errors = copy.deepcopy(_copy._ignored_errors)
+ self._warn_errors = copy.deepcopy(_copy._warn_errors)
+ self._reference = _copy._reference
+ self._regions = _copy._regions
+ if reference: self._reference = reference
+ if regions: self._regions = regions
+ if leftalign: self._leftalign = leftalign
+ self._lines = lines
+
+ def error(self,line,error,opt=None):
+ if error in self._ignored_errors: return
+ errorlabel, errorstring = self._errors[error].split(':')
+ if opt: errorstring = errorstring % opt
+ errwarn = ["Error","Warning"][error in self._warn_errors]
+ sys.stderr.write("Line %s: '%s'\n%s %s: %s\n" % (self._lineno,line,errwarn,errorlabel,errorstring))
+ if error in self._warn_errors: return
+ raise ValueError(errorstring)
+
+ def parse_format(self,line,format,filter=False):
+ if self._version == 40:
+ if not format.startswith('<'):
+ self.error(line,self.V40_MISSING_ANGLE_BRACKETS)
+ format = "<"+format
+ if not format.endswith('>'):
+ self.error(line,self.V40_MISSING_ANGLE_BRACKETS)
+ format += ">"
+ format = format[1:-1]
+ data = {'id':None,'number':None,'type':None,'descr':None}
+ idx = 0
+ while len(format.strip())>0:
+ elts = format.strip().split(',')
+ first, rest = elts[0], ','.join(elts[1:])
+ if first.find('=') == -1 or (first.find('"')>=0 and first.find('=') > first.find('"')):
+ if self._version == 40: self.error(line,self.V40_FORMAT_MUST_HAVE_NAMED_FIELDS)
+ if idx == 4: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ first = ["ID=","Number=","Type=","Description="][idx] + first
+ if first.startswith('ID='): data['id'] = first.split('=')[1]
+ elif first.startswith('Number='): data['number'] = first.split('=')[1]
+ elif first.startswith('Type='): data['type'] = first.split('=')[1]
+ elif first.startswith('Description='):
+ elts = format.split('"')
+ if len(elts)<3:
+ self.error(line,self.FORMAT_MISSING_QUOTES)
+ elts = first.split('=') + [rest]
+ data['descr'] = elts[1]
+ rest = '"'.join(elts[2:])
+ if rest.startswith(','): rest = rest[1:]
+ else:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ format = rest
+ idx += 1
+ if filter and idx==1: idx=3 # skip number and type fields for FILTER format strings
+ if not data['id']: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ if not data['descr']:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ data['descr'] = '<none>'
+ if not data['type'] and not data['number']:
+ # fine, ##filter format
+ return FORMAT(data['id'],self.NT_NUMBER,0,"Flag",data['descr'],'.')
+ if not data['type'] in ["Integer","Float","Character","String","Flag"]:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ # I would like a missing-value field, but it isn't there
+ if data['type'] in ['Integer','Float']: data['missing'] = None # Do NOT use arbitrary int/float as missing value
+ else: data['missing'] = '.'
+ if not data['number']: self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ try:
+ n = int(data['number'])
+ t = self.NT_NUMBER
+ except ValueError:
+ n = -1
+ if data['number'] == '.': t = self.NT_UNKNOWN
+ elif data['number'] == '#alleles': t = self.NT_ALLELES
+ elif data['number'] == '#nonref_alleles': t = self.NT_NR_ALLELES
+ elif data['number'] == '#genotypes': t = self.NT_GENOTYPES
+ elif data['number'] == '#phased_genotypes': t = self.NT_PHASED_GENOTYPES
+ else:
+ self.error(line,self.BADLY_FORMATTED_FORMAT_STRING)
+ return FORMAT(data['id'],t,n,data['type'],data['descr'],data['missing'])
+
+
+ def format_format( self, fmt, filter=False ):
+ values = [('ID',fmt.id)]
+ if fmt.number != None and not filter:
+ if fmt.numbertype == self.NT_UNKNOWN: nmb = "."
+ elif fmt.numbertype == self.NT_NUMBER: nmb = str(fmt.number)
+ elif fmt.numbertype == self.NT_ALLELES: nmb = "#alleles"
+ elif fmt.numbertype == self.NT_NR_ALLELES: nmb = "#nonref_alleles"
+ elif fmt.numbertype == self.NT_GENOTYPES: nmb = "#genotypes"
+ elif fmt.numbertype == self.NT_PHASED_GENOTYPES: nmb = "#phased_genotypes"
+ else:
+ raise ValueError("Unknown number type encountered: %s" % fmt.numbertype)
+ values.append( ('Number',nmb) )
+ values.append( ('Type', fmt.type) )
+ values.append( ('Description', '"' + fmt.description + '"') )
+ if self._version == 33:
+ format = ",".join([v for k,v in values])
+ else:
+ format = "<" + (",".join( ["%s=%s" % (k,v) for (k,v) in values] )) + ">"
+ return format
+
+ def get_expected(self, format, formatdict, alt):
+ fmt = formatdict[format]
+ if fmt.numbertype == self.NT_UNKNOWN: return -1
+ if fmt.numbertype == self.NT_NUMBER: return fmt.number
+ if fmt.numbertype == self.NT_ALLELES: return len(alt)+1
+ if fmt.numbertype == self.NT_NR_ALLELES: return len(alt)
+ if fmt.numbertype == self.NT_GENOTYPES: return ((len(alt)+1)*(len(alt)+2)) // 2
+ if fmt.numbertype == self.NT_PHASED_GENOTYPES: return (len(alt)+1)*(len(alt)+1)
+ return 0
+
+
+ def _add_definition(self, formatdict, key, data, line ):
+ if key in formatdict: return
+ self.error(line,self.ERROR_UNKNOWN_KEY,key)
+ if data == None:
+ formatdict[key] = FORMAT(key,self.NT_NUMBER,0,"Flag","(Undefined tag)",".")
+ return
+ if data == []: data = [""] # unsure what type -- say string
+ if type(data[0]) == type(0.0):
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"Float","(Undefined tag)",None)
+ return
+ if type(data[0]) == type(0):
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"Integer","(Undefined tag)",None)
+ return
+ formatdict[key] = FORMAT(key,self.NT_UNKNOWN,-1,"String","(Undefined tag)",".")
+
+
+ # todo: trim trailing missing values
+ def format_formatdata( self, data, format, key=True, value=True, separator=":" ):
+ output, sdata = [], []
+ if type(data) == type([]): # for FORMAT field, make data with dummy values
+ d = {}
+ for k in data: d[k] = []
+ data = d
+ # convert missing values; and silently add definitions if required
+ for k in data:
+ self._add_definition( format, k, data[k], "(output)" )
+ for idx,v in enumerate(data[k]):
+ if v == format[k].missingvalue: data[k][idx] = "."
+ # make sure GT comes first; and ensure fixed ordering; also convert GT data back to string
+ for k in data:
+ if k != 'GT': sdata.append( (k,data[k]) )
+ sdata.sort()
+ if 'GT' in data:
+ sdata = [('GT',map(self.convertGTback,data['GT']))] + sdata
+ for k,v in sdata:
+ if v == []: v = None
+ if key and value:
+ if v != None: output.append( k+"="+','.join(map(str,v)) )
+ else: output.append( k )
+ elif key: output.append(k)
+ elif value:
+ if v != None: output.append( ','.join(map(str,v)) )
+ else: output.append( "." ) # should not happen
+ # snip off trailing missing data
+ while len(output) > 1:
+ last = output[-1].replace(',','').replace('.','')
+ if len(last)>0: break
+ output = output[:-1]
+ return separator.join(output)
+
+
+ def enter_default_format(self):
+ for f in [FORMAT('GT',self.NT_NUMBER,1,'String','Genotype','.'),
+ FORMAT('GQ',self.NT_NUMBER,1,'Integer','Genotype Quality',-1),
+ FORMAT('DP',self.NT_NUMBER,1,'Integer','Read depth at this position for this sample',-1),
+ FORMAT('HQ',self.NT_UNKNOWN,-1,'Integer','Haplotype Quality',-1), # unknown number, since may be haploid
+ FORMAT('FT',self.NT_NUMBER,1,'String','Sample Genotype Filter','.')]:
+ if f.id not in self._format:
+ self._format[f.id] = f
+
+ def parse_header( self, line ):
+ assert line.startswith('##')
+ elts = line[2:].split('=')
+ key = elts[0].strip()
+ value = '='.join(elts[1:]).strip()
+ if key == "fileformat":
+ if value == "VCFv3.3":
+ self._version = 33
+ elif value == "VCFv4.0":
+ self._version = 40
+ elif value == "VCFv4.1":
+ # AH - for testing
+ self._version = 40
+ else:
+ self.error(line,self.UNKNOWN_FORMAT_STRING)
+ elif key == "INFO":
+ f = self.parse_format(line, value)
+ self._info[ f.id ] = f
+ elif key == "FILTER":
+ f = self.parse_format(line, value, filter=True)
+ self._filter[ f.id ] = f
+ elif key == "FORMAT":
+ f = self.parse_format(line, value)
+ self._format[ f.id ] = f
+ else:
+ # keep other keys in the header field
+ self._header.append( (key,value) )
+
+
+ def write_header( self, stream ):
+ stream.write("##fileformat=VCFv%s.%s\n" % (self._version // 10, self._version % 10))
+ for key,value in self._header: stream.write("##%s=%s\n" % (key,value))
+ for var,label in [(self._info,"INFO"),(self._filter,"FILTER"),(self._format,"FORMAT")]:
+ for f in var.itervalues(): stream.write("##%s=%s\n" % (label,self.format_format(f,filter=(label=="FILTER"))))
+
+
+ def parse_heading( self, line ):
+ assert line.startswith('#')
+ assert not line.startswith('##')
+ headings = line[1:].split('\t')
+ if len(headings)==1 and len(line[1:].split()) >= 9:
+ self.error(line,self.HEADING_NOT_SEPARATED_BY_TABS)
+ headings = line[1:].split()
+
+ for i,s in enumerate(self._required):
+
+ if len(headings)<=i or headings[i] != s:
+
+ if len(headings) <= i:
+ err = "(%sth entry not found)" % (i+1)
+ else:
+ err = "(found %s, expected %s)" % (headings[i],s)
+
+ #self.error(line,self.BADLY_FORMATTED_HEADING,err)
+
+ # allow FORMAT column to be absent
+ if len(headings) == 8:
+ headings.append("FORMAT")
+ else:
+ self.error(line,self.BADLY_FORMATTED_HEADING,err)
+
+ self._samples = headings[9:]
+ self._sample2column = dict( [(y,x+9) for x,y in enumerate( self._samples ) ] )
+
+ def write_heading( self, stream ):
+ stream.write("#" + "\t".join(self._required + self._samples) + "\n")
+
+ def convertGT(self, GTstring):
+ if GTstring == ".": return ["."]
+ try:
+ gts = gtsRegEx.split(GTstring)
+ if len(gts) == 1: return [int(gts[0])]
+ if len(gts) != 2: raise ValueError()
+ if gts[0] == "." and gts[1] == ".": return [gts[0],GTstring[len(gts[0]):-len(gts[1])],gts[1]]
+ return [int(gts[0]),GTstring[len(gts[0]):-len(gts[1])],int(gts[1])]
+ except ValueError:
+ self.error(self._line,self.BAD_GENOTYPE,GTstring)
+ return [".","|","."]
+
+
+ def convertGTback(self, GTdata):
+ return ''.join(map(str,GTdata))
+
+ def parse_formatdata( self, key, value, formatdict, line ):
+ # To do: check that the right number of values is present
+ f = formatdict.get(key,None)
+ if f == None:
+ self._add_definition(formatdict, key, value, line )
+ f = formatdict[key]
+ if f.type == "Flag":
+ if value is not None: self.error(line,self.ERROR_FLAG_HAS_VALUE)
+ return []
+ values = value.split(',')
+ # deal with trailing data in some early VCF files
+ if f.type in ["Float","Integer"] and len(values)>0 and values[-1].find(';') > -1:
+ self.error(line,self.ERROR_TRAILING_DATA,values[-1])
+ values[-1] = values[-1].split(';')[0]
+ if f.type == "Integer":
+ for idx,v in enumerate(values):
+ try:
+ if v == ".": values[idx] = f.missingvalue
+ else: values[idx] = int(v)
+ except:
+ self.error(line,self.ERROR_FORMAT_NOT_NUMERICAL,values)
+ return [0] * len(values)
+ return values
+ elif f.type == "String":
+ self._line = line
+ if f.id == "GT": values = map( self.convertGT, values )
+ return values
+ elif f.type == "Character":
+ for v in values:
+ if len(v) != 1: self.error(line,self.ERROR_FORMAT_NOT_CHAR)
+ return values
+ elif f.type == "Float":
+ for idx,v in enumerate(values):
+ if v == ".": values[idx] = f.missingvalue
+ try: return map(float,values)
+ except:
+ self.error(line,self.ERROR_FORMAT_NOT_NUMERICAL,values)
+ return [0.0] * len(values)
+ else:
+ # can't happen
+ self.error(line,self.ERROR_INFO_STRING)
+
+
+ def inregion(self, chrom, pos):
+ if not self._regions: return True
+ for r in self._regions:
+ if r[0] == chrom and r[1] <= pos < r[2]: return True
+ return False
+
+
+ def parse_data( self, line, lineparse=False ):
+ cols = line.split('\t')
+ if len(cols) != len(self._samples)+9:
+ # gracefully deal with absent FORMAT column
+ if len(cols) == 8 and len(self._samples)==0:
+ cols.append("")
+ else:
+ self.error(line,
+ self.BAD_NUMBER_OF_COLUMNS,
+ "expected %s for %s samples (%s), got %s" % (len(self._samples)+9, len(self._samples), self._samples, len(cols)))
+
+ chrom = cols[0]
+
+ # get 0-based position
+ try: pos = int(cols[1])-1
+ except: self.error(line,self.POS_NOT_NUMERICAL)
+ if pos < 0: self.error(line,self.POS_NOT_POSITIVE)
+
+ # implement filtering
+ if not self.inregion(chrom,pos): return None
+
+ # end of first-pass parse for sortedVCF
+ if lineparse: return chrom, pos, line
+
+ id = cols[2]
+
+ ref = cols[3].upper()
+ if ref == ".":
+ self.error(line,self.MISSING_REF)
+ if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
+ else: ref = ""
+ else:
+ for c in ref:
+ if c not in "ACGTN": self.error(line,self.UNKNOWN_CHAR_IN_REF)
+ if "N" in ref: ref = get_sequence(chrom,pos,pos+len(ref),self._reference)
+
+ # make sure reference is sane
+ if self._reference:
+ left = max(0,pos-100)
+ faref_leftflank = get_sequence(chrom,left,pos+len(ref),self._reference)
+ faref = faref_leftflank[pos-left:]
+ if faref != ref: self.error(line,self.WRONG_REF,"(reference is %s, VCF says %s)" % (faref,ref))
+ ref = faref
+
+ # convert v3.3 to v4.0 alleles below
+ if cols[4] == ".": alt = []
+ else: alt = cols[4].upper().split(',')
+
+ if cols[5] == ".": qual = -1
+ else:
+ try: qual = float(cols[5])
+ except: self.error(line,self.QUAL_NOT_NUMERICAL)
+
+ # postpone checking that filters exist. Encode missing filter or no filtering as empty list
+ if cols[6] == "." or cols[6] == "PASS" or cols[6] == "0": filter = []
+ else: filter = cols[6].split(';')
+
+ # dictionary of keys, and list of values
+ info = {}
+ if cols[7] != ".":
+ for blurp in cols[7].split(';'):
+ elts = blurp.split('=')
+ if len(elts) == 1: v = None
+ elif len(elts) == 2: v = elts[1]
+ else: self.error(line,self.ERROR_INFO_STRING)
+ info[elts[0]] = self.parse_formatdata(elts[0], v, self._info, line)
+
+ # Gracefully deal with absent FORMAT column
+ if cols[8] == "": format = []
+ else: format = cols[8].split(':')
+
+ # check: all filters are defined
+ for f in filter:
+ if f not in self._filter: self.error(line,self.FILTER_NOT_DEFINED, f)
+
+ # check: format fields are defined
+ for f in format:
+ if f not in self._format: self.error(line,self.FORMAT_NOT_DEFINED, f)
+
+ # convert v3.3 alleles
+ if self._version == 33:
+ if len(ref) != 1: self.error(line,self.V33_BAD_REF)
+ newalts = []
+ have_deletions = False
+ for a in alt:
+ if len(a) == 1: a = a + ref[1:] # SNP; add trailing reference
+ elif a.startswith('I'): a = ref[0] + a[1:] + ref[1:] # insertion just beyond pos; add first and trailing reference
+ elif a.startswith('D'): # allow D<seq> and D<num>
+ have_deletions = True
+ try:
+ l = int(a[1:]) # throws ValueError if sequence
+ if len(ref) < l: # add to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[l:] # new deletion, deleting pos...pos+l
+ except ValueError:
+ s = a[1:]
+ if len(ref) < len(s): # add Ns to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ if not s.endswith(addns) and addns != 'N'*len(addns):
+ self.error(line,self.V33_UNMATCHED_DELETION,
+ "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[len(s):] # new deletion, deleting from pos
+ else:
+ self.error(line,self.V33_BAD_ALLELE)
+ newalts.append(a)
+ alt = newalts
+ # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ if have_deletions:
+ if pos == 0:
+ # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ ref += addn
+ alt = [allele+addn for allele in alt]
+ else:
+ addn = get_sequence(chrom,pos-1,pos,self._reference)
+ ref = addn + ref
+ alt = [addn + allele for allele in alt]
+ pos -= 1
+ else:
+ # format v4.0 -- just check for nucleotides
+ for allele in alt:
+ if not alleleRegEx.match(allele):
+ self.error(line,self.V40_BAD_ALLELE,allele)
+
+ # check for leading nucleotide in indel calls
+ for allele in alt:
+ if len(allele) != len(ref):
+ if len(allele) == 0: self.error(line,self.ZERO_LENGTH_ALLELE)
+ if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
+ self.error(line,self.MISSING_INDEL_ALLELE_REF_BASE)
+
+ # trim trailing bases in alleles
+ for i in range(1,min(len(ref),min(map(len,alt)))):
+ if len(set(allele[-1].upper() for allele in alt)) > 1 or ref[-1].upper() != alt[0][-1].upper():
+ break
+ ref, alt = ref[:-1], [allele[:-1] for allele in alt]
+
+ # left-align alleles, if a reference is available
+ if self._leftalign and self._reference:
+ while left < pos:
+ movable = True
+ for allele in alt:
+ if len(allele) > len(ref):
+ longest, shortest = allele, ref
+ else:
+ longest, shortest = ref, allele
+ if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ movable = False
+ if longest[-1].upper() != longest[len(shortest)-1].upper():
+ movable = False
+ if not movable:
+ break
+ ref = ref[:-1]
+ alt = [allele[:-1] for allele in alt]
+ if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
+ ref = faref_leftflank[pos-left-1] + ref
+ alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
+ pos -= 1
+
+ # parse sample columns
+ samples = []
+ for sample in cols[9:]:
+ dict = {}
+ values = sample.split(':')
+ if len(values) > len(format):
+ self.error(line,self.BAD_NUMBER_OF_VALUES,"(found %s values in element %s; expected %s)" % (len(values),sample,len(format)))
+ for idx in range(len(format)):
+ expected = self.get_expected(format[idx], self._format, alt)
+ if idx < len(values): value = values[idx]
+ else:
+ if expected == -1: value = "."
+ else: value = ",".join(["."]*expected)
+ dict[format[idx]] = self.parse_formatdata(format[idx], value, self._format, line)
+ if expected != -1 and len(dict[format[idx]]) != expected:
+ self.error(line,self.BAD_NUMBER_OF_PARAMETERS,
+ "id=%s, expected %s parameters, got %s" % (format[idx],expected,dict[format[idx]]))
+ if len(dict[format[idx]] ) < expected: dict[format[idx]] += [dict[format[idx]][-1]]*(expected-len(dict[format[idx]]))
+ dict[format[idx]] = dict[format[idx]][:expected]
+ samples.append( dict )
+
+ # done
+ d = {'chrom':chrom,
+ 'pos':pos, # return 0-based position
+ 'id':id,
+ 'ref':ref,
+ 'alt':alt,
+ 'qual':qual,
+ 'filter':filter,
+ 'info':info,
+ 'format':format}
+ for key,value in zip(self._samples,samples):
+ d[key] = value
+
+ return d
+
+
+ def write_data(self, stream, data):
+ required = ['chrom','pos','id','ref','alt','qual','filter','info','format'] + self._samples
+ for k in required:
+ if k not in data: raise ValueError("Required key %s not found in data" % str(k))
+ if data['alt'] == []: alt = "."
+ else: alt = ",".join(data['alt'])
+ if data['filter'] == None: filter = "."
+ elif data['filter'] == []:
+ if self._version == 33: filter = "0"
+ else: filter = "PASS"
+ else: filter = ';'.join(data['filter'])
+ if data['qual'] == -1: qual = "."
+ else: qual = str(data['qual'])
+
+ output = [data['chrom'],
+ str(data['pos']+1), # change to 1-based position
+ data['id'],
+ data['ref'],
+ alt,
+ qual,
+ filter,
+ self.format_formatdata( data['info'], self._info, separator=";" ),
+ self.format_formatdata( data['format'], self._format, value=False ) ]
+
+ for s in self._samples:
+ output.append( self.format_formatdata( data[s], self._format, key=False ) )
+
+ stream.write( "\t".join(output) + "\n" )
+
+ def _parse_header(self, stream):
+ self._lineno = 0
+ for line in stream:
+ self._lineno += 1
+ if line.startswith('##'):
+ self.parse_header( line.strip() )
+ elif line.startswith('#'):
+ self.parse_heading( line.strip() )
+ self.enter_default_format()
+ else:
+ break
+ return line
+
+ def _parse(self, line, stream):
+ if len(line.strip()) > 0:
+ d = self.parse_data( line.strip() )
+ #if d: yield d
+ for line in stream:
+ self._lineno += 1
+ if self._lines and self._lineno > self._lines: raise StopIteration
+ d = self.parse_data( line.strip() )
+ #if d: yield d
+
+ ######################################################################################################
+ #
+ # API follows
+ #
+ ######################################################################################################
+
+ def getsamples(self):
+ """ List of samples in VCF file """
+ return self._samples
+
+ def setsamples(self,samples):
+ """ List of samples in VCF file """
+ self._samples = samples
+
+ def getheader(self):
+ """ List of header key-value pairs (strings) """
+ return self._header
+
+ def setheader(self,header):
+ """ List of header key-value pairs (strings) """
+ self._header = header
+
+ def getinfo(self):
+ """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ return self._info
+
+ def setinfo(self,info):
+ """ Dictionary of ##INFO tags, as VCF.FORMAT values """
+ self._info = info
+
+ def getformat(self):
+ """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ return self._format
+
+ def setformat(self,format):
+ """ Dictionary of ##FORMAT tags, as VCF.FORMAT values """
+ self._format = format
+
+ def getfilter(self):
+ """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ return self._filter
+
+ def setfilter(self,filter):
+ """ Dictionary of ##FILTER tags, as VCF.FORMAT values """
+ self._filter = filter
+
+ def setversion(self, version):
+ if version != 33 and version != 40: raise ValueError("Can only handle v3.3 and v4.0 VCF files")
+ self._version = version
+
+ def setregions(self, regions):
+ self._regions = regions
+
+ def setreference(self, ref):
+ """ Provide a reference sequence; a Python class supporting a fetch(chromosome, start, end) method, e.g. PySam.FastaFile """
+ self._reference = ref
+
+ def ignoreerror(self, errorstring):
+ try: self._ignored_errors.add(self.__dict__[errorstring])
+ except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+
+ def warnerror(self, errorstring):
+ try: self._warn_errors.add(self.__dict__[errorstring])
+ except KeyError: raise ValueError("Invalid error string: %s" % errorstring)
+
+ def parse(self, stream):
+ """ Parse a stream of VCF-formatted lines. Initializes class instance and return generator """
+ last_line = self._parse_header(stream)
+ # now return a generator that does the actual work. In this way the pre-processing is done
+ # before the first piece of data is yielded
+ return self._parse(last_line, stream)
+
+ def write(self, stream, datagenerator):
+ """ Writes a VCF file to a stream, using a data generator (or list) """
+ self.write_header(stream)
+ self.write_heading(stream)
+ for data in datagenerator: self.write_data(stream,data)
+
+ def writeheader(self, stream):
+ """ Writes a VCF header """
+ self.write_header(stream)
+ self.write_heading(stream)
+
+ def compare_calls(self, pos1, ref1, alt1, pos2, ref2, alt2):
+ """ Utility function: compares two calls for equality """
+ # a variant should always be assigned to a unique position, one base before
+ # the leftmost position of the alignment gap. If this rule is implemented
+ # correctly, the two positions must be equal for the calls to be identical.
+ if pos1 != pos2: return False
+ # from both calls, trim rightmost bases when identical. Do this safely, i.e.
+ # only when the reference bases are not Ns
+ while len(ref1)>0 and len(alt1)>0 and ref1[-1] == alt1[-1]:
+ ref1 = ref1[:-1]
+ alt1 = alt1[:-1]
+ while len(ref2)>0 and len(alt2)>0 and ref2[-1] == alt2[-1]:
+ ref2 = ref2[:-1]
+ alt2 = alt2[:-1]
+ # now, the alternative alleles must be identical
+ return alt1 == alt2
+
+###########################################################################################################
+###########################################################################################################
+## API functions added by Andreas
+###########################################################################################################
+
+ def connect( self, filename ):
+ '''connect to tabix file.'''
+ self.tabixfile = pysam.Tabixfile( filename )
+ self._parse_header(self.tabixfile.header)
+
+ def fetch(self,
+ reference = None,
+ start = None,
+ end = None,
+ region = None ):
+ """ Parse a stream of VCF-formatted lines. Initializes class instance and return generator """
+
+ return self.tabixfile.fetch( reference, start, end, region, parser = asVCFRecord( self ) )
+
+ def validate( self, record ):
+ '''validate vcf record.
+
+ returns a validated record.
+ '''
+
+ raise NotImplementedError( "needs to be checked" )
+
+ chrom, pos = record.chrom, record.pos
+
+ # check reference
+ ref = record.ref
+ if ref == ".":
+ self.error(str(record),self.MISSING_REF)
+ if self._version == 33: ref = get_sequence(chrom,pos,pos+1,self._reference)
+ else: ref = ""
+ else:
+ for c in ref:
+ if c not in "ACGTN": self.error(str(record),self.UNKNOWN_CHAR_IN_REF)
+ if "N" in ref: ref = get_sequence(chrom,
+ pos,
+ pos+len(ref),
+ self._reference)
+
+ # make sure reference is sane
+ if self._reference:
+ left = max(0,self.pos-100)
+ faref_leftflank = get_sequence(chrom,left,self.pos+len(ref),self._reference)
+ faref = faref_leftflank[pos-left:]
+ if faref != ref: self.error(str(record),self.WRONG_REF,"(reference is %s, VCF says %s)" % (faref,ref))
+ ref = faref
+
+ # check: format fields are defined
+ for f in record.format:
+ if f not in self._format: self.error(str(record),self.FORMAT_NOT_DEFINED, f)
+
+ # check: all filters are defined
+ for f in record.filter:
+ if f not in self._filter: self.error(str(record),self.FILTER_NOT_DEFINED, f)
+
+ # convert v3.3 alleles
+ if self._version == 33:
+ if len(ref) != 1: self.error(str(record),self.V33_BAD_REF)
+ newalts = []
+ have_deletions = False
+ for a in alt:
+ if len(a) == 1: a = a + ref[1:] # SNP; add trailing reference
+ elif a.startswith('I'): a = ref[0] + a[1:] + ref[1:] # insertion just beyond pos; add first and trailing reference
+ elif a.startswith('D'): # allow D<seq> and D<num>
+ have_deletions = True
+ try:
+ l = int(a[1:]) # throws ValueError if sequence
+ if len(ref) < l: # add to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+l,self._reference)
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[l:] # new deletion, deleting pos...pos+l
+ except ValueError:
+ s = a[1:]
+ if len(ref) < len(s): # add Ns to reference if necessary
+ addns = get_sequence(chrom,pos+len(ref),pos+len(s),self._reference)
+ if not s.endswith(addns) and addns != 'N'*len(addns):
+ self.error(str(record),self.V33_UNMATCHED_DELETION,
+ "(deletion is %s, reference is %s)" % (a,get_sequence(chrom,pos,pos+len(s),self._reference)))
+ ref += addns
+ for i,na in enumerate(newalts): newalts[i] = na+addns
+ a = ref[len(s):] # new deletion, deleting from pos
+ else:
+ self.error(str(record),self.V33_BAD_ALLELE)
+ newalts.append(a)
+ alt = newalts
+ # deletion alleles exist, add dummy 1st reference allele, and account for leading base
+ if have_deletions:
+ if pos == 0:
+ # Petr Danacek's: we can't have a leading nucleotide at (1-based) position 1
+ addn = get_sequence(chrom,pos+len(ref),pos+len(ref)+1,self._reference)
+ ref += addn
+ alt = [allele+addn for allele in alt]
+ else:
+ addn = get_sequence(chrom,pos-1,pos,self._reference)
+ ref = addn + ref
+ alt = [addn + allele for allele in alt]
+ pos -= 1
+ else:
+ # format v4.0 -- just check for nucleotides
+ for allele in alt:
+ if not alleleRegEx.match(allele):
+ self.error(str(record),self.V40_BAD_ALLELE,allele)
+
+
+ # check for leading nucleotide in indel calls
+ for allele in alt:
+ if len(allele) != len(ref):
+ if len(allele) == 0: self.error(str(record),self.ZERO_LENGTH_ALLELE)
+ if ref[0].upper() != allele[0].upper() and "N" not in (ref[0]+allele[0]).upper():
+ self.error(str(record),self.MISSING_INDEL_ALLELE_REF_BASE)
+
+ # trim trailing bases in alleles
+ for i in range(1,min(len(ref),min(map(len,alt)))):
+ if len(set(allele[-1].upper() for allele in alt)) > 1 or ref[-1].upper() != alt[0][-1].upper():
+ break
+ ref, alt = ref[:-1], [allele[:-1] for allele in alt]
+
+ # left-align alleles, if a reference is available
+ if self._leftalign and self._reference:
+ while left < pos:
+ movable = True
+ for allele in alt:
+ if len(allele) > len(ref):
+ longest, shortest = allele, ref
+ else:
+ longest, shortest = ref, allele
+ if len(longest) == len(shortest) or longest[:len(shortest)].upper() != shortest.upper():
+ movable = False
+ if longest[-1].upper() != longest[len(shortest)-1].upper():
+ movable = False
+ if not movable:
+ break
+ ref = ref[:-1]
+ alt = [allele[:-1] for allele in alt]
+ if min([len(allele) for allele in alt]) == 0 or len(ref) == 0:
+ ref = faref_leftflank[pos-left-1] + ref
+ alt = [faref_leftflank[pos-left-1] + allele for allele in alt]
+ pos -= 1
+
+__all__ = [
+ "VCF", "VCFRecord", ]
+
+
#include "bam_endian.h"
#include "knetfile.h"
#include "pysam_util.h"
+#include "errmod.h" // for pysam_dump
+
+#ifndef inline
+#define inline __inline
+#endif
+
+// Definition of pysamerr
+#include "stdio.h"
+FILE * pysamerr = NULL;
+
+FILE * pysam_set_stderr( FILE * f )
+{
+ pysamerr = f;
+ return f;
+}
// #######################################################
// utility routines to avoid using callbacks in bam_fetch
KSORT_INIT(my_off, pair64_t, pair64_lt);
KHASH_MAP_INIT_INT(my_i, bam_binlist_t);
+KHASH_MAP_INIT_STR(s, int)
struct __bam_index_t
{
return 1;
}
+typedef struct __bmc_aux_t {
+ int max;
+ uint32_t *info;
+ uint16_t *info16;
+ errmod_t *em;
+} bmc_aux_t;
+
+uint32_t pysam_glf_depth( glf1_t * g )
+{
+ return g->depth;
+}
+
+
+void pysam_dump_glf( glf1_t * g, bam_maqcns_t * c )
+{
+ int x = 0;
+ fprintf(stderr,
+ "glf: ref_base=%i, max_mapQ=%i, min_lk=%i, depth=%i",
+ g->ref_base,
+ g->max_mapQ,
+ g->min_lk,
+ g->depth );
+
+ for (x = 0; x < 10; ++x)
+ fprintf(stderr, ", lk%x=%i, ", x, g->lk[x]);
+
+ fprintf(stderr,
+ "maqcns: het_rate=%f, theta=%f, n_hap=%i, cap_mapQ=%i, errmod=%i, min_baseQ=%i, eta=%f, q_r=%f, aux_max=%i",
+ c->het_rate,
+ c->theta,
+ c->n_hap,
+ c->cap_mapQ,
+ c->errmod,
+ c->min_baseQ,
+ c->eta,
+ c->q_r,
+ c->aux->max);
+
+ for (x = 0; x < c->aux->max; ++x)
+ {
+ fprintf(stderr, ", info-%i=%i ", x, c->aux->info[x]);
+ if (c->aux->info[x] == 0) break;
+ }
+
+ for (x = 0; x < c->aux->max; ++x)
+ {
+ fprintf(stderr, ", info16-%i=%i ", x, c->aux->info16[x]);
+ if (c->aux->info16[x] == 0) break;
+ }
+}
+
+
+
+
// pysam dispatch function to emulate the samtools
// command line within python.
// taken from the main function in bamtk.c
int pysam_dispatch(int argc, char *argv[] )
{
-
+ extern int optind;
#ifdef _WIN32
setmode(fileno(stdout), O_BINARY);
setmode(fileno(stdin), O_BINARY);
knet_win32_init();
#endif
#endif
-
- extern int optind;
// reset getop
optind = 1;
else if (strcmp(argv[1], "pileup") == 0) return bam_pileup(argc-1, argv+1);
else if (strcmp(argv[1], "merge") == 0) return bam_merge(argc-1, argv+1);
else if (strcmp(argv[1], "sort") == 0) return bam_sort(argc-1, argv+1);
- else if (strcmp(argv[1], "index") == 0) return bam_index(argc-1, argv+1);
+ else if (strcmp(argv[1], "index") == 0) return bam_index(argc-1, argv+1);
else if (strcmp(argv[1], "faidx") == 0) return faidx_main(argc-1, argv+1);
else if (strcmp(argv[1], "fixmate") == 0) return bam_mating(argc-1, argv+1);
else if (strcmp(argv[1], "rmdup") == 0) return bam_rmdup(argc-1, argv+1);
uint8_t * pos )
{
int d = nbytes_new-nbytes_old;
+ int new_size;
+ size_t offset;
// no change
if (d == 0) return b;
- int new_size = d + b->data_len;
- size_t offset = pos - b->data;
+ new_size = d + b->data_len;
+ offset = pos - b->data;
//printf("d=%i, old=%i, new=%i, old_size=%i, new_size=%i\n",
// d, nbytes_old, nbytes_new, b->data_len, new_size);
}
+void bam_init_header_hash(bam_header_t *header);
+
+// translate a reference string *s* to a tid
+// code taken from bam_parse_region
+int pysam_reference2tid( bam_header_t *header, const char * s )
+{
+
+ khiter_t iter;
+ khash_t(s) *h;
+
+ bam_init_header_hash(header);
+ h = (khash_t(s)*)header->hash;
+
+ iter = kh_get(s, h, s); /* get the ref_id */
+ if (iter == kh_end(h)) { // name not found
+ return -1;
+ }
+
+ return kh_value(h, iter);
+}
+
+
+
+
+
+
#ifndef PYSAM_UTIL_H
#define PYSAM_UTIL_H
+//////////////////////////////////////////////////////////////////
+// set pysam standard error to point to stream
+FILE * pysam_set_stderr( FILE * f );
+
//////////////////////////////////////////////////////////////////
//////////////////////////////////////////////////////////////////
//////////////////////////////////////////////////////////////////
// translate a nucleotide character to binary code
unsigned char pysam_translate_sequence( const unsigned char s );
+// defined in bam_import.c
+extern unsigned char bam_nt16_table[256];
+
+// translate a reference string *s* to a tid
+int pysam_reference2tid( bam_header_t *header, const char * s );
+
+// debugging functions
+#include "glf.h"
+uint32_t pysam_glf_depth( glf1_t * g);
+
+#include "bam_maqcns.h"
+void pysam_dump_glf( glf1_t * g, bam_maqcns_t * c );
+
#endif
--- /dev/null
+// Definition of pysamerr
+#include "stdio.h"
+FILE * pysamerr = NULL;
+
# pysam versioning information
-__version__ = "0.3.1"
+__version__ = "0.5"
-__samtools_version__ = "0.1.8"
+__samtools_version__ = "0.1.16"
-__tabix_version__ = "0.2.1"
+__tabix_version__ = "0.2.5"
+++ /dev/null
-#include <stdio.h>
-#include <ctype.h>
-#include <errno.h>
-#include <assert.h>
-#include "bam.h"
-#include "bam_endian.h"
-#include "kstring.h"
-#include "sam_header.h"
-
-int bam_is_be = 0;
-char *bam_flag2char_table = "pPuUrR12sfd\0\0\0\0\0";
-
-/**************************
- * CIGAR related routines *
- **************************/
-
-uint32_t bam_calend(const bam1_core_t *c, const uint32_t *cigar)
-{
- uint32_t k, end;
- end = c->pos;
- for (k = 0; k < c->n_cigar; ++k) {
- int op = cigar[k] & BAM_CIGAR_MASK;
- if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP)
- end += cigar[k] >> BAM_CIGAR_SHIFT;
- }
- return end;
-}
-
-int32_t bam_cigar2qlen(const bam1_core_t *c, const uint32_t *cigar)
-{
- uint32_t k;
- int32_t l = 0;
- for (k = 0; k < c->n_cigar; ++k) {
- int op = cigar[k] & BAM_CIGAR_MASK;
- if (op == BAM_CMATCH || op == BAM_CINS || op == BAM_CSOFT_CLIP)
- l += cigar[k] >> BAM_CIGAR_SHIFT;
- }
- return l;
-}
-
-/********************
- * BAM I/O routines *
- ********************/
-
-bam_header_t *bam_header_init()
-{
- bam_is_be = bam_is_big_endian();
- return (bam_header_t*)calloc(1, sizeof(bam_header_t));
-}
-
-void bam_header_destroy(bam_header_t *header)
-{
- int32_t i;
- extern void bam_destroy_header_hash(bam_header_t *header);
- if (header == 0) return;
- if (header->target_name) {
- for (i = 0; i < header->n_targets; ++i)
- free(header->target_name[i]);
- free(header->target_name);
- free(header->target_len);
- }
- free(header->text);
- if (header->dict) sam_header_free(header->dict);
- if (header->rg2lib) sam_tbl_destroy(header->rg2lib);
- bam_destroy_header_hash(header);
- free(header);
-}
-
-bam_header_t *bam_header_read(bamFile fp)
-{
- bam_header_t *header;
- char buf[4];
- int magic_len;
- int32_t i = 1, name_len;
- // check EOF
- i = bgzf_check_EOF(fp);
- if (i < 0) {
- // If the file is a pipe, checking the EOF marker will *always* fail
- // with ESPIPE. Suppress the error message in this case.
- if (errno != ESPIPE) perror("[bam_header_read] bgzf_check_EOF");
- }
- else if (i == 0) fprintf(stderr, "[bam_header_read] EOF marker is absent.\n");
- // read "BAM1"
- magic_len = bam_read(fp, buf, 4);
- if (magic_len != 4 || strncmp(buf, "BAM\001", 4) != 0) {
- fprintf(stderr, "[bam_header_read] invalid BAM binary header (this is not a BAM file).\n");
- return 0;
- }
- header = bam_header_init();
- // read plain text and the number of reference sequences
- bam_read(fp, &header->l_text, 4);
- if (bam_is_be) bam_swap_endian_4p(&header->l_text);
- header->text = (char*)calloc(header->l_text + 1, 1);
- bam_read(fp, header->text, header->l_text);
- bam_read(fp, &header->n_targets, 4);
- if (bam_is_be) bam_swap_endian_4p(&header->n_targets);
- // read reference sequence names and lengths
- header->target_name = (char**)calloc(header->n_targets, sizeof(char*));
- header->target_len = (uint32_t*)calloc(header->n_targets, 4);
- for (i = 0; i != header->n_targets; ++i) {
- bam_read(fp, &name_len, 4);
- if (bam_is_be) bam_swap_endian_4p(&name_len);
- header->target_name[i] = (char*)calloc(name_len, 1);
- bam_read(fp, header->target_name[i], name_len);
- bam_read(fp, &header->target_len[i], 4);
- if (bam_is_be) bam_swap_endian_4p(&header->target_len[i]);
- }
- return header;
-}
-
-int bam_header_write(bamFile fp, const bam_header_t *header)
-{
- char buf[4];
- int32_t i, name_len, x;
- // write "BAM1"
- strncpy(buf, "BAM\001", 4);
- bam_write(fp, buf, 4);
- // write plain text and the number of reference sequences
- if (bam_is_be) {
- x = bam_swap_endian_4(header->l_text);
- bam_write(fp, &x, 4);
- if (header->l_text) bam_write(fp, header->text, header->l_text);
- x = bam_swap_endian_4(header->n_targets);
- bam_write(fp, &x, 4);
- } else {
- bam_write(fp, &header->l_text, 4);
- if (header->l_text) bam_write(fp, header->text, header->l_text);
- bam_write(fp, &header->n_targets, 4);
- }
- // write sequence names and lengths
- for (i = 0; i != header->n_targets; ++i) {
- char *p = header->target_name[i];
- name_len = strlen(p) + 1;
- if (bam_is_be) {
- x = bam_swap_endian_4(name_len);
- bam_write(fp, &x, 4);
- } else bam_write(fp, &name_len, 4);
- bam_write(fp, p, name_len);
- if (bam_is_be) {
- x = bam_swap_endian_4(header->target_len[i]);
- bam_write(fp, &x, 4);
- } else bam_write(fp, &header->target_len[i], 4);
- }
- bgzf_flush(fp);
- return 0;
-}
-
-static void swap_endian_data(const bam1_core_t *c, int data_len, uint8_t *data)
-{
- uint8_t *s;
- uint32_t i, *cigar = (uint32_t*)(data + c->l_qname);
- s = data + c->n_cigar*4 + c->l_qname + c->l_qseq + (c->l_qseq + 1)/2;
- for (i = 0; i < c->n_cigar; ++i) bam_swap_endian_4p(&cigar[i]);
- while (s < data + data_len) {
- uint8_t type;
- s += 2; // skip key
- type = toupper(*s); ++s; // skip type
- if (type == 'C' || type == 'A') ++s;
- else if (type == 'S') { bam_swap_endian_2p(s); s += 2; }
- else if (type == 'I' || type == 'F') { bam_swap_endian_4p(s); s += 4; }
- else if (type == 'D') { bam_swap_endian_8p(s); s += 8; }
- else if (type == 'Z' || type == 'H') { while (*s) ++s; ++s; }
- }
-}
-
-int bam_read1(bamFile fp, bam1_t *b)
-{
- bam1_core_t *c = &b->core;
- int32_t block_len, ret, i;
- uint32_t x[8];
-
- assert(BAM_CORE_SIZE == 32);
- if ((ret = bam_read(fp, &block_len, 4)) != 4) {
- if (ret == 0) return -1; // normal end-of-file
- else return -2; // truncated
- }
- if (bam_read(fp, x, BAM_CORE_SIZE) != BAM_CORE_SIZE) return -3;
- if (bam_is_be) {
- bam_swap_endian_4p(&block_len);
- for (i = 0; i < 8; ++i) bam_swap_endian_4p(x + i);
- }
- c->tid = x[0]; c->pos = x[1];
- c->bin = x[2]>>16; c->qual = x[2]>>8&0xff; c->l_qname = x[2]&0xff;
- c->flag = x[3]>>16; c->n_cigar = x[3]&0xffff;
- c->l_qseq = x[4];
- c->mtid = x[5]; c->mpos = x[6]; c->isize = x[7];
- b->data_len = block_len - BAM_CORE_SIZE;
- if (b->m_data < b->data_len) {
- b->m_data = b->data_len;
- kroundup32(b->m_data);
- b->data = (uint8_t*)realloc(b->data, b->m_data);
- }
- if (bam_read(fp, b->data, b->data_len) != b->data_len) return -4;
- b->l_aux = b->data_len - c->n_cigar * 4 - c->l_qname - c->l_qseq - (c->l_qseq+1)/2;
- if (bam_is_be) swap_endian_data(c, b->data_len, b->data);
- return 4 + block_len;
-}
-
-inline int bam_write1_core(bamFile fp, const bam1_core_t *c, int data_len, uint8_t *data)
-{
- uint32_t x[8], block_len = data_len + BAM_CORE_SIZE, y;
- int i;
- assert(BAM_CORE_SIZE == 32);
- x[0] = c->tid;
- x[1] = c->pos;
- x[2] = (uint32_t)c->bin<<16 | c->qual<<8 | c->l_qname;
- x[3] = (uint32_t)c->flag<<16 | c->n_cigar;
- x[4] = c->l_qseq;
- x[5] = c->mtid;
- x[6] = c->mpos;
- x[7] = c->isize;
- bgzf_flush_try(fp, 4 + block_len);
- if (bam_is_be) {
- for (i = 0; i < 8; ++i) bam_swap_endian_4p(x + i);
- y = block_len;
- bam_write(fp, bam_swap_endian_4p(&y), 4);
- swap_endian_data(c, data_len, data);
- } else bam_write(fp, &block_len, 4);
- bam_write(fp, x, BAM_CORE_SIZE);
- bam_write(fp, data, data_len);
- if (bam_is_be) swap_endian_data(c, data_len, data);
- return 4 + block_len;
-}
-
-int bam_write1(bamFile fp, const bam1_t *b)
-{
- return bam_write1_core(fp, &b->core, b->data_len, b->data);
-}
-
-char *bam_format1_core(const bam_header_t *header, const bam1_t *b, int of)
-{
- uint8_t *s = bam1_seq(b), *t = bam1_qual(b);
- int i;
- const bam1_core_t *c = &b->core;
- kstring_t str;
- str.l = str.m = 0; str.s = 0;
-
- kputsn(bam1_qname(b), c->l_qname-1, &str); kputc('\t', &str);
- if (of == BAM_OFDEC) { kputw(c->flag, &str); kputc('\t', &str); }
- else if (of == BAM_OFHEX) ksprintf(&str, "0x%x\t", c->flag);
- else { // BAM_OFSTR
- for (i = 0; i < 16; ++i)
- if ((c->flag & 1<<i) && bam_flag2char_table[i])
- kputc(bam_flag2char_table[i], &str);
- kputc('\t', &str);
- }
- if (c->tid < 0) kputsn("*\t", 2, &str);
- else { kputs(header->target_name[c->tid], &str); kputc('\t', &str); }
- kputw(c->pos + 1, &str); kputc('\t', &str); kputw(c->qual, &str); kputc('\t', &str);
- if (c->n_cigar == 0) kputc('*', &str);
- else {
- for (i = 0; i < c->n_cigar; ++i) {
- kputw(bam1_cigar(b)[i]>>BAM_CIGAR_SHIFT, &str);
- kputc("MIDNSHP"[bam1_cigar(b)[i]&BAM_CIGAR_MASK], &str);
- }
- }
- kputc('\t', &str);
- if (c->mtid < 0) kputsn("*\t", 2, &str);
- else if (c->mtid == c->tid) kputsn("=\t", 2, &str);
- else { kputs(header->target_name[c->mtid], &str); kputc('\t', &str); }
- kputw(c->mpos + 1, &str); kputc('\t', &str); kputw(c->isize, &str); kputc('\t', &str);
- if (c->l_qseq) {
- for (i = 0; i < c->l_qseq; ++i) kputc(bam_nt16_rev_table[bam1_seqi(s, i)], &str);
- kputc('\t', &str);
- if (t[0] == 0xff) kputc('*', &str);
- else for (i = 0; i < c->l_qseq; ++i) kputc(t[i] + 33, &str);
- } else kputsn("*\t*", 3, &str);
- s = bam1_aux(b);
- while (s < b->data + b->data_len) {
- uint8_t type, key[2];
- key[0] = s[0]; key[1] = s[1];
- s += 2; type = *s; ++s;
- kputc('\t', &str); kputsn((char*)key, 2, &str); kputc(':', &str);
- if (type == 'A') { kputsn("A:", 2, &str); kputc(*s, &str); ++s; }
- else if (type == 'C') { kputsn("i:", 2, &str); kputw(*s, &str); ++s; }
- else if (type == 'c') { kputsn("i:", 2, &str); kputw(*(int8_t*)s, &str); ++s; }
- else if (type == 'S') { kputsn("i:", 2, &str); kputw(*(uint16_t*)s, &str); s += 2; }
- else if (type == 's') { kputsn("i:", 2, &str); kputw(*(int16_t*)s, &str); s += 2; }
- else if (type == 'I') { kputsn("i:", 2, &str); kputuw(*(uint32_t*)s, &str); s += 4; }
- else if (type == 'i') { kputsn("i:", 2, &str); kputw(*(int32_t*)s, &str); s += 4; }
- else if (type == 'f') { ksprintf(&str, "f:%g", *(float*)s); s += 4; }
- else if (type == 'd') { ksprintf(&str, "d:%lg", *(double*)s); s += 8; }
- else if (type == 'Z' || type == 'H') { kputc(type, &str); kputc(':', &str); while (*s) kputc(*s++, &str); ++s; }
- }
- return str.s;
-}
-
-char *bam_format1(const bam_header_t *header, const bam1_t *b)
-{
- return bam_format1_core(header, b, BAM_OFDEC);
-}
-
-void bam_view1(const bam_header_t *header, const bam1_t *b)
-{
- char *s = bam_format1(header, b);
- puts(s);
- free(s);
-}
-
-// FIXME: we should also check the LB tag associated with each alignment
-const char *bam_get_library(bam_header_t *h, const bam1_t *b)
-{
- const uint8_t *rg;
- if (h->dict == 0) h->dict = sam_header_parse2(h->text);
- if (h->rg2lib == 0) h->rg2lib = sam_header2tbl(h->dict, "RG", "ID", "LB");
- rg = bam_aux_get(b, "RG");
- return (rg == 0)? 0 : sam_tbl_get(h->rg2lib, (const char*)(rg + 1));
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdio.h>
+#include <ctype.h>
+#include <errno.h>
+#include <assert.h>
+#include "bam.h"
+#include "bam_endian.h"
+#include "kstring.h"
+#include "sam_header.h"
+
+int bam_is_be = 0, bam_verbose = 2;
+char *bam_flag2char_table = "pPuUrR12sfd\0\0\0\0\0";
+
+/**************************
+ * CIGAR related routines *
+ **************************/
+
+uint32_t bam_calend(const bam1_core_t *c, const uint32_t *cigar)
+{
+ uint32_t k, end;
+ end = c->pos;
+ for (k = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k] & BAM_CIGAR_MASK;
+ if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP)
+ end += cigar[k] >> BAM_CIGAR_SHIFT;
+ }
+ return end;
+}
+
+int32_t bam_cigar2qlen(const bam1_core_t *c, const uint32_t *cigar)
+{
+ uint32_t k;
+ int32_t l = 0;
+ for (k = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k] & BAM_CIGAR_MASK;
+ if (op == BAM_CMATCH || op == BAM_CINS || op == BAM_CSOFT_CLIP)
+ l += cigar[k] >> BAM_CIGAR_SHIFT;
+ }
+ return l;
+}
+
+/********************
+ * BAM I/O routines *
+ ********************/
+
+bam_header_t *bam_header_init()
+{
+ bam_is_be = bam_is_big_endian();
+ return (bam_header_t*)calloc(1, sizeof(bam_header_t));
+}
+
+void bam_header_destroy(bam_header_t *header)
+{
+ int32_t i;
+ extern void bam_destroy_header_hash(bam_header_t *header);
+ if (header == 0) return;
+ if (header->target_name) {
+ for (i = 0; i < header->n_targets; ++i)
+ free(header->target_name[i]);
+ free(header->target_name);
+ free(header->target_len);
+ }
+ free(header->text);
+ if (header->dict) sam_header_free(header->dict);
+ if (header->rg2lib) sam_tbl_destroy(header->rg2lib);
+ bam_destroy_header_hash(header);
+ free(header);
+}
+
+bam_header_t *bam_header_read(bamFile fp)
+{
+ bam_header_t *header;
+ char buf[4];
+ int magic_len;
+ int32_t i = 1, name_len;
+ // check EOF
+ i = bgzf_check_EOF(fp);
+ if (i < 0) {
+ // If the file is a pipe, checking the EOF marker will *always* fail
+ // with ESPIPE. Suppress the error message in this case.
+ if (errno != ESPIPE) perror("[bam_header_read] bgzf_check_EOF");
+ }
+ else if (i == 0) fprintf(pysamerr, "[bam_header_read] EOF marker is absent. The input is probably truncated.\n");
+ // read "BAM1"
+ magic_len = bam_read(fp, buf, 4);
+ if (magic_len != 4 || strncmp(buf, "BAM\001", 4) != 0) {
+ fprintf(pysamerr, "[bam_header_read] invalid BAM binary header (this is not a BAM file).\n");
+ return 0;
+ }
+ header = bam_header_init();
+ // read plain text and the number of reference sequences
+ bam_read(fp, &header->l_text, 4);
+ if (bam_is_be) bam_swap_endian_4p(&header->l_text);
+ header->text = (char*)calloc(header->l_text + 1, 1);
+ bam_read(fp, header->text, header->l_text);
+ bam_read(fp, &header->n_targets, 4);
+ if (bam_is_be) bam_swap_endian_4p(&header->n_targets);
+ // read reference sequence names and lengths
+ header->target_name = (char**)calloc(header->n_targets, sizeof(char*));
+ header->target_len = (uint32_t*)calloc(header->n_targets, 4);
+ for (i = 0; i != header->n_targets; ++i) {
+ bam_read(fp, &name_len, 4);
+ if (bam_is_be) bam_swap_endian_4p(&name_len);
+ header->target_name[i] = (char*)calloc(name_len, 1);
+ bam_read(fp, header->target_name[i], name_len);
+ bam_read(fp, &header->target_len[i], 4);
+ if (bam_is_be) bam_swap_endian_4p(&header->target_len[i]);
+ }
+ return header;
+}
+
+int bam_header_write(bamFile fp, const bam_header_t *header)
+{
+ char buf[4];
+ int32_t i, name_len, x;
+ // write "BAM1"
+ strncpy(buf, "BAM\001", 4);
+ bam_write(fp, buf, 4);
+ // write plain text and the number of reference sequences
+ if (bam_is_be) {
+ x = bam_swap_endian_4(header->l_text);
+ bam_write(fp, &x, 4);
+ if (header->l_text) bam_write(fp, header->text, header->l_text);
+ x = bam_swap_endian_4(header->n_targets);
+ bam_write(fp, &x, 4);
+ } else {
+ bam_write(fp, &header->l_text, 4);
+ if (header->l_text) bam_write(fp, header->text, header->l_text);
+ bam_write(fp, &header->n_targets, 4);
+ }
+ // write sequence names and lengths
+ for (i = 0; i != header->n_targets; ++i) {
+ char *p = header->target_name[i];
+ name_len = strlen(p) + 1;
+ if (bam_is_be) {
+ x = bam_swap_endian_4(name_len);
+ bam_write(fp, &x, 4);
+ } else bam_write(fp, &name_len, 4);
+ bam_write(fp, p, name_len);
+ if (bam_is_be) {
+ x = bam_swap_endian_4(header->target_len[i]);
+ bam_write(fp, &x, 4);
+ } else bam_write(fp, &header->target_len[i], 4);
+ }
+ bgzf_flush(fp);
+ return 0;
+}
+
+static void swap_endian_data(const bam1_core_t *c, int data_len, uint8_t *data)
+{
+ uint8_t *s;
+ uint32_t i, *cigar = (uint32_t*)(data + c->l_qname);
+ s = data + c->n_cigar*4 + c->l_qname + c->l_qseq + (c->l_qseq + 1)/2;
+ for (i = 0; i < c->n_cigar; ++i) bam_swap_endian_4p(&cigar[i]);
+ while (s < data + data_len) {
+ uint8_t type;
+ s += 2; // skip key
+ type = toupper(*s); ++s; // skip type
+ if (type == 'C' || type == 'A') ++s;
+ else if (type == 'S') { bam_swap_endian_2p(s); s += 2; }
+ else if (type == 'I' || type == 'F') { bam_swap_endian_4p(s); s += 4; }
+ else if (type == 'D') { bam_swap_endian_8p(s); s += 8; }
+ else if (type == 'Z' || type == 'H') { while (*s) ++s; ++s; }
+ else if (type == 'B') {
+ int32_t n, Bsize = bam_aux_type2size(*s);
+ memcpy(&n, s + 1, 4);
+ if (1 == Bsize) {
+ } else if (2 == Bsize) {
+ for (i = 0; i < n; i += 2)
+ bam_swap_endian_2p(s + 5 + i);
+ } else if (4 == Bsize) {
+ for (i = 0; i < n; i += 4)
+ bam_swap_endian_4p(s + 5 + i);
+ }
+ bam_swap_endian_4p(s+1);
+ }
+ }
+}
+
+int bam_read1(bamFile fp, bam1_t *b)
+{
+ bam1_core_t *c = &b->core;
+ int32_t block_len, ret, i;
+ uint32_t x[8];
+
+ assert(BAM_CORE_SIZE == 32);
+ if ((ret = bam_read(fp, &block_len, 4)) != 4) {
+ if (ret == 0) return -1; // normal end-of-file
+ else return -2; // truncated
+ }
+ if (bam_read(fp, x, BAM_CORE_SIZE) != BAM_CORE_SIZE) return -3;
+ if (bam_is_be) {
+ bam_swap_endian_4p(&block_len);
+ for (i = 0; i < 8; ++i) bam_swap_endian_4p(x + i);
+ }
+ c->tid = x[0]; c->pos = x[1];
+ c->bin = x[2]>>16; c->qual = x[2]>>8&0xff; c->l_qname = x[2]&0xff;
+ c->flag = x[3]>>16; c->n_cigar = x[3]&0xffff;
+ c->l_qseq = x[4];
+ c->mtid = x[5]; c->mpos = x[6]; c->isize = x[7];
+ b->data_len = block_len - BAM_CORE_SIZE;
+ if (b->m_data < b->data_len) {
+ b->m_data = b->data_len;
+ kroundup32(b->m_data);
+ b->data = (uint8_t*)realloc(b->data, b->m_data);
+ }
+ if (bam_read(fp, b->data, b->data_len) != b->data_len) return -4;
+ b->l_aux = b->data_len - c->n_cigar * 4 - c->l_qname - c->l_qseq - (c->l_qseq+1)/2;
+ if (bam_is_be) swap_endian_data(c, b->data_len, b->data);
+ return 4 + block_len;
+}
+
+inline int bam_write1_core(bamFile fp, const bam1_core_t *c, int data_len, uint8_t *data)
+{
+ uint32_t x[8], block_len = data_len + BAM_CORE_SIZE, y;
+ int i;
+ assert(BAM_CORE_SIZE == 32);
+ x[0] = c->tid;
+ x[1] = c->pos;
+ x[2] = (uint32_t)c->bin<<16 | c->qual<<8 | c->l_qname;
+ x[3] = (uint32_t)c->flag<<16 | c->n_cigar;
+ x[4] = c->l_qseq;
+ x[5] = c->mtid;
+ x[6] = c->mpos;
+ x[7] = c->isize;
+ bgzf_flush_try(fp, 4 + block_len);
+ if (bam_is_be) {
+ for (i = 0; i < 8; ++i) bam_swap_endian_4p(x + i);
+ y = block_len;
+ bam_write(fp, bam_swap_endian_4p(&y), 4);
+ swap_endian_data(c, data_len, data);
+ } else bam_write(fp, &block_len, 4);
+ bam_write(fp, x, BAM_CORE_SIZE);
+ bam_write(fp, data, data_len);
+ if (bam_is_be) swap_endian_data(c, data_len, data);
+ return 4 + block_len;
+}
+
+int bam_write1(bamFile fp, const bam1_t *b)
+{
+ return bam_write1_core(fp, &b->core, b->data_len, b->data);
+}
+
+char *bam_format1_core(const bam_header_t *header, const bam1_t *b, int of)
+{
+ uint8_t *s = bam1_seq(b), *t = bam1_qual(b);
+ int i;
+ const bam1_core_t *c = &b->core;
+ kstring_t str;
+ str.l = str.m = 0; str.s = 0;
+
+ kputsn(bam1_qname(b), c->l_qname-1, &str); kputc('\t', &str);
+ if (of == BAM_OFDEC) { kputw(c->flag, &str); kputc('\t', &str); }
+ else if (of == BAM_OFHEX) ksprintf(&str, "0x%x\t", c->flag);
+ else { // BAM_OFSTR
+ for (i = 0; i < 16; ++i)
+ if ((c->flag & 1<<i) && bam_flag2char_table[i])
+ kputc(bam_flag2char_table[i], &str);
+ kputc('\t', &str);
+ }
+ if (c->tid < 0) kputsn("*\t", 2, &str);
+ else {
+ if (header) kputs(header->target_name[c->tid] , &str);
+ else kputw(c->tid, &str);
+ kputc('\t', &str);
+ }
+ kputw(c->pos + 1, &str); kputc('\t', &str); kputw(c->qual, &str); kputc('\t', &str);
+ if (c->n_cigar == 0) kputc('*', &str);
+ else {
+ for (i = 0; i < c->n_cigar; ++i) {
+ kputw(bam1_cigar(b)[i]>>BAM_CIGAR_SHIFT, &str);
+ kputc("MIDNSHP"[bam1_cigar(b)[i]&BAM_CIGAR_MASK], &str);
+ }
+ }
+ kputc('\t', &str);
+ if (c->mtid < 0) kputsn("*\t", 2, &str);
+ else if (c->mtid == c->tid) kputsn("=\t", 2, &str);
+ else {
+ if (header) kputs(header->target_name[c->mtid], &str);
+ else kputw(c->mtid, &str);
+ kputc('\t', &str);
+ }
+ kputw(c->mpos + 1, &str); kputc('\t', &str); kputw(c->isize, &str); kputc('\t', &str);
+ if (c->l_qseq) {
+ for (i = 0; i < c->l_qseq; ++i) kputc(bam_nt16_rev_table[bam1_seqi(s, i)], &str);
+ kputc('\t', &str);
+ if (t[0] == 0xff) kputc('*', &str);
+ else for (i = 0; i < c->l_qseq; ++i) kputc(t[i] + 33, &str);
+ } else kputsn("*\t*", 3, &str);
+ s = bam1_aux(b);
+ while (s < b->data + b->data_len) {
+ uint8_t type, key[2];
+ key[0] = s[0]; key[1] = s[1];
+ s += 2; type = *s; ++s;
+ kputc('\t', &str); kputsn((char*)key, 2, &str); kputc(':', &str);
+ if (type == 'A') { kputsn("A:", 2, &str); kputc(*s, &str); ++s; }
+ else if (type == 'C') { kputsn("i:", 2, &str); kputw(*s, &str); ++s; }
+ else if (type == 'c') { kputsn("i:", 2, &str); kputw(*(int8_t*)s, &str); ++s; }
+ else if (type == 'S') { kputsn("i:", 2, &str); kputw(*(uint16_t*)s, &str); s += 2; }
+ else if (type == 's') { kputsn("i:", 2, &str); kputw(*(int16_t*)s, &str); s += 2; }
+ else if (type == 'I') { kputsn("i:", 2, &str); kputuw(*(uint32_t*)s, &str); s += 4; }
+ else if (type == 'i') { kputsn("i:", 2, &str); kputw(*(int32_t*)s, &str); s += 4; }
+ else if (type == 'f') { ksprintf(&str, "f:%g", *(float*)s); s += 4; }
+ else if (type == 'd') { ksprintf(&str, "d:%lg", *(double*)s); s += 8; }
+ else if (type == 'Z' || type == 'H') { kputc(type, &str); kputc(':', &str); while (*s) kputc(*s++, &str); ++s; }
+ else if (type == 'B') {
+ uint8_t sub_type = *(s++);
+ int32_t n;
+ memcpy(&n, s, 4);
+ s += 4; // no point to the start of the array
+ kputc(type, &str); kputc(':', &str); kputc(sub_type, &str); // write the typing
+ for (i = 0; i < n; ++i) {
+ kputc(',', &str);
+ if ('c' == sub_type || 'c' == sub_type) { kputw(*(int8_t*)s, &str); ++s; }
+ else if ('C' == sub_type) { kputw(*(uint8_t*)s, &str); ++s; }
+ else if ('s' == sub_type) { kputw(*(int16_t*)s, &str); s += 2; }
+ else if ('S' == sub_type) { kputw(*(uint16_t*)s, &str); s += 2; }
+ else if ('i' == sub_type) { kputw(*(int32_t*)s, &str); s += 4; }
+ else if ('I' == sub_type) { kputuw(*(uint32_t*)s, &str); s += 4; }
+ else if ('f' == sub_type) { ksprintf(&str, "%g", *(float*)s); s += 4; }
+ }
+ }
+ }
+ return str.s;
+}
+
+char *bam_format1(const bam_header_t *header, const bam1_t *b)
+{
+ return bam_format1_core(header, b, BAM_OFDEC);
+}
+
+void bam_view1(const bam_header_t *header, const bam1_t *b)
+{
+ char *s = bam_format1(header, b);
+ puts(s);
+ free(s);
+}
+
+int bam_validate1(const bam_header_t *header, const bam1_t *b)
+{
+ char *s;
+
+ if (b->core.tid < -1 || b->core.mtid < -1) return 0;
+ if (header && (b->core.tid >= header->n_targets || b->core.mtid >= header->n_targets)) return 0;
+
+ if (b->data_len < b->core.l_qname) return 0;
+ s = memchr(bam1_qname(b), '\0', b->core.l_qname);
+ if (s != &bam1_qname(b)[b->core.l_qname-1]) return 0;
+
+ // FIXME: Other fields could also be checked, especially the auxiliary data
+
+ return 1;
+}
+
+// FIXME: we should also check the LB tag associated with each alignment
+const char *bam_get_library(bam_header_t *h, const bam1_t *b)
+{
+ const uint8_t *rg;
+ if (h->dict == 0) h->dict = sam_header_parse2(h->text);
+ if (h->rg2lib == 0) h->rg2lib = sam_header2tbl(h->dict, "RG", "ID", "LB");
+ rg = bam_aux_get(b, "RG");
+ return (rg == 0)? 0 : sam_tbl_get(h->rg2lib, (const char*)(rg + 1));
+}
/* The MIT License
- Copyright (c) 2008 Genome Research Ltd (GRL).
+ Copyright (c) 2008-2010 Genome Research Ltd (GRL).
Permission is hereby granted, free of charge, to any person obtaining
a copy of this software and associated documentation files (the
BAM library provides I/O and various operations on manipulating files
in the BAM (Binary Alignment/Mapping) or SAM (Sequence Alignment/Map)
- format. It now supports importing from or exporting to TAM, sorting,
+ format. It now supports importing from or exporting to SAM, sorting,
merging, generating pileup, and quickly retrieval of reads overlapped
with a specified region.
@copyright Genome Research Ltd.
*/
+#define BAM_VERSION "0.1.16 (r963:234)"
+
#include <stdint.h>
#include <stdlib.h>
#include <string.h>
@param b pointer to an alignment
@return pointer to quality string
*/
-#define bam1_qual(b) ((b)->data + (b)->core.n_cigar*4 + (b)->core.l_qname + ((b)->core.l_qseq + 1)/2)
+#define bam1_qual(b) ((b)->data + (b)->core.n_cigar*4 + (b)->core.l_qname + (((b)->core.l_qseq + 1)>>1))
/*! @function
@abstract Get a base on read
*/
extern int bam_is_be;
+/*!
+ @abstract Verbose level between 0 and 3; 0 is supposed to disable all
+ debugging information, though this may not have been implemented.
+ */
+extern int bam_verbose;
+
/*! @abstract Table for converting a nucleotide character to the 4-bit encoding. */
extern unsigned char bam_nt16_table[256];
char *bam_format1_core(const bam_header_t *header, const bam1_t *b, int of);
+ /*!
+ @abstract Check whether a BAM record is plausibly valid
+ @param header associated header structure, or NULL if unavailable
+ @param b alignment to validate
+ @return 0 if the alignment is invalid; non-zero otherwise
+
+ @discussion Simple consistency check of some of the fields of the
+ alignment record. If the header is provided, several additional checks
+ are made. Not all fields are checked, so a non-zero result is not a
+ guarantee that the record is valid. However it is usually good enough
+ to detect when bam_seek() has been called with a virtual file offset
+ that is not the offset of an alignment record.
+ */
+ int bam_validate1(const bam_header_t *header, const bam1_t *b);
+
const char *bam_get_library(bam_header_t *header, const bam1_t *b);
bam1_t *b;
int32_t qpos;
int indel, level;
- uint32_t is_del:1, is_head:1, is_tail:1;
+ uint32_t is_del:1, is_head:1, is_tail:1, is_refskip:1, aux:28;
} bam_pileup1_t;
typedef int (*bam_plp_auto_f)(void *data, bam1_t *b);
const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp);
const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp);
void bam_plp_set_mask(bam_plp_t iter, int mask);
+ void bam_plp_set_maxcnt(bam_plp_t iter, int maxcnt);
void bam_plp_reset(bam_plp_t iter);
void bam_plp_destroy(bam_plp_t iter);
bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data);
void bam_mplp_destroy(bam_mplp_t iter);
+ void bam_mplp_set_maxcnt(bam_mplp_t iter, int maxcnt);
int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp);
/*! @typedef
{
uint8_t *data = bdst->data;
int m_data = bdst->m_data; // backup data and m_data
- if (m_data < bsrc->m_data) { // double the capacity
- m_data = bsrc->m_data; kroundup32(m_data);
+ if (m_data < bsrc->data_len) { // double the capacity
+ m_data = bsrc->data_len; kroundup32(m_data);
data = (uint8_t*)realloc(data, m_data);
}
memcpy(data, bsrc->data, bsrc->data_len); // copy var-len data
return b;
}
+static inline int bam_aux_type2size(int x)
+{
+ if (x == 'C' || x == 'c' || x == 'A') return 1;
+ else if (x == 'S' || x == 's') return 2;
+ else if (x == 'I' || x == 'i' || x == 'f') return 4;
+ else return 0;
+}
+
+
#endif
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include <stdint.h>
+#include "bam.h"
+#include "kstring.h"
+#include "bam2bcf.h"
+#include "errmod.h"
+#include "bcftools/bcf.h"
+
+extern void ks_introsort_uint32_t(size_t n, uint32_t a[]);
+
+#define CALL_ETA 0.03f
+#define CALL_MAX 256
+#define CALL_DEFTHETA 0.83f
+#define DEF_MAPQ 20
+
+#define CAP_DIST 25
+
+bcf_callaux_t *bcf_call_init(double theta, int min_baseQ)
+{
+ bcf_callaux_t *bca;
+ if (theta <= 0.) theta = CALL_DEFTHETA;
+ bca = calloc(1, sizeof(bcf_callaux_t));
+ bca->capQ = 60;
+ bca->openQ = 40; bca->extQ = 20; bca->tandemQ = 100;
+ bca->min_baseQ = min_baseQ;
+ bca->e = errmod_init(1. - theta);
+ bca->min_frac = 0.002;
+ bca->min_support = 1;
+ return bca;
+}
+
+void bcf_call_destroy(bcf_callaux_t *bca)
+{
+ if (bca == 0) return;
+ errmod_destroy(bca->e);
+ free(bca->bases); free(bca->inscns); free(bca);
+}
+/* ref_base is the 4-bit representation of the reference base. It is
+ * negative if we are looking at an indel. */
+int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base, bcf_callaux_t *bca, bcf_callret1_t *r)
+{
+ int i, n, ref4, is_indel, ori_depth = 0;
+ memset(r, 0, sizeof(bcf_callret1_t));
+ if (ref_base >= 0) {
+ ref4 = bam_nt16_nt4_table[ref_base];
+ is_indel = 0;
+ } else ref4 = 4, is_indel = 1;
+ if (_n == 0) return -1;
+ // enlarge the bases array if necessary
+ if (bca->max_bases < _n) {
+ bca->max_bases = _n;
+ kroundup32(bca->max_bases);
+ bca->bases = (uint16_t*)realloc(bca->bases, 2 * bca->max_bases);
+ }
+ // fill the bases array
+ memset(r, 0, sizeof(bcf_callret1_t));
+ for (i = n = 0; i < _n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ int q, b, mapQ, baseQ, is_diff, min_dist, seqQ;
+ // set base
+ if (p->is_del || p->is_refskip || (p->b->core.flag&BAM_FUNMAP)) continue;
+ ++ori_depth;
+ baseQ = q = is_indel? p->aux&0xff : (int)bam1_qual(p->b)[p->qpos]; // base/indel quality
+ seqQ = is_indel? (p->aux>>8&0xff) : 99;
+ if (q < bca->min_baseQ) continue;
+ if (q > seqQ) q = seqQ;
+ mapQ = p->b->core.qual < 255? p->b->core.qual : DEF_MAPQ; // special case for mapQ==255
+ mapQ = mapQ < bca->capQ? mapQ : bca->capQ;
+ if (q > mapQ) q = mapQ;
+ if (q > 63) q = 63;
+ if (q < 4) q = 4;
+ if (!is_indel) {
+ b = bam1_seqi(bam1_seq(p->b), p->qpos); // base
+ b = bam_nt16_nt4_table[b? b : ref_base]; // b is the 2-bit base
+ is_diff = (ref4 < 4 && b == ref4)? 0 : 1;
+ } else {
+ b = p->aux>>16&0x3f;
+ is_diff = (b != 0);
+ }
+ bca->bases[n++] = q<<5 | (int)bam1_strand(p->b)<<4 | b;
+ // collect annotations
+ if (b < 4) r->qsum[b] += q;
+ ++r->anno[0<<2|is_diff<<1|bam1_strand(p->b)];
+ min_dist = p->b->core.l_qseq - 1 - p->qpos;
+ if (min_dist > p->qpos) min_dist = p->qpos;
+ if (min_dist > CAP_DIST) min_dist = CAP_DIST;
+ r->anno[1<<2|is_diff<<1|0] += baseQ;
+ r->anno[1<<2|is_diff<<1|1] += baseQ * baseQ;
+ r->anno[2<<2|is_diff<<1|0] += mapQ;
+ r->anno[2<<2|is_diff<<1|1] += mapQ * mapQ;
+ r->anno[3<<2|is_diff<<1|0] += min_dist;
+ r->anno[3<<2|is_diff<<1|1] += min_dist * min_dist;
+ }
+ r->depth = n; r->ori_depth = ori_depth;
+ // glfgen
+ errmod_cal(bca->e, n, 5, bca->bases, r->p);
+ return r->depth;
+}
+
+int bcf_call_combine(int n, const bcf_callret1_t *calls, int ref_base /*4-bit*/, bcf_call_t *call)
+{
+ int ref4, i, j, qsum[4];
+ int64_t tmp;
+ if (ref_base >= 0) {
+ call->ori_ref = ref4 = bam_nt16_nt4_table[ref_base];
+ if (ref4 > 4) ref4 = 4;
+ } else call->ori_ref = -1, ref4 = 0;
+ // calculate qsum
+ memset(qsum, 0, 4 * sizeof(int));
+ for (i = 0; i < n; ++i)
+ for (j = 0; j < 4; ++j)
+ qsum[j] += calls[i].qsum[j];
+ for (j = 0; j < 4; ++j) qsum[j] = qsum[j] << 2 | j;
+ // find the top 2 alleles
+ for (i = 1; i < 4; ++i) // insertion sort
+ for (j = i; j > 0 && qsum[j] < qsum[j-1]; --j)
+ tmp = qsum[j], qsum[j] = qsum[j-1], qsum[j-1] = tmp;
+ // set the reference allele and alternative allele(s)
+ for (i = 0; i < 5; ++i) call->a[i] = -1;
+ call->unseen = -1;
+ call->a[0] = ref4;
+ for (i = 3, j = 1; i >= 0; --i) {
+ if ((qsum[i]&3) != ref4) {
+ if (qsum[i]>>2 != 0) call->a[j++] = qsum[i]&3;
+ else break;
+ }
+ }
+ if (ref_base >= 0) { // for SNPs, find the "unseen" base
+ if (((ref4 < 4 && j < 4) || (ref4 == 4 && j < 5)) && i >= 0)
+ call->unseen = j, call->a[j++] = qsum[i]&3;
+ call->n_alleles = j;
+ } else {
+ call->n_alleles = j;
+ if (call->n_alleles == 1) return -1; // no reliable supporting read. stop doing anything
+ }
+ // set the PL array
+ if (call->n < n) {
+ call->n = n;
+ call->PL = realloc(call->PL, 15 * n);
+ }
+ {
+ int x, g[15], z;
+ double sum_min = 0.;
+ x = call->n_alleles * (call->n_alleles + 1) / 2;
+ // get the possible genotypes
+ for (i = z = 0; i < call->n_alleles; ++i)
+ for (j = 0; j <= i; ++j)
+ g[z++] = call->a[j] * 5 + call->a[i];
+ for (i = 0; i < n; ++i) {
+ uint8_t *PL = call->PL + x * i;
+ const bcf_callret1_t *r = calls + i;
+ float min = 1e37;
+ for (j = 0; j < x; ++j)
+ if (min > r->p[g[j]]) min = r->p[g[j]];
+ sum_min += min;
+ for (j = 0; j < x; ++j) {
+ int y;
+ y = (int)(r->p[g[j]] - min + .499);
+ if (y > 255) y = 255;
+ PL[j] = y;
+ }
+ }
+// if (ref_base < 0) fprintf(pysamerr, "%d,%d,%f,%d\n", call->n_alleles, x, sum_min, call->unseen);
+ call->shift = (int)(sum_min + .499);
+ }
+ // combine annotations
+ memset(call->anno, 0, 16 * sizeof(int));
+ for (i = call->depth = call->ori_depth = 0, tmp = 0; i < n; ++i) {
+ call->depth += calls[i].depth;
+ call->ori_depth += calls[i].ori_depth;
+ for (j = 0; j < 16; ++j) call->anno[j] += calls[i].anno[j];
+ }
+ return 0;
+}
+
+int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b, bcf_callret1_t *bcr, int is_SP,
+ const bcf_callaux_t *bca, const char *ref)
+{
+ extern double kt_fisher_exact(int n11, int n12, int n21, int n22, double *_left, double *_right, double *two);
+ kstring_t s;
+ int i, j;
+ b->n_smpl = bc->n;
+ b->tid = tid; b->pos = pos; b->qual = 0;
+ s.s = b->str; s.m = b->m_str; s.l = 0;
+ kputc('\0', &s);
+ if (bc->ori_ref < 0) { // an indel
+ // write REF
+ kputc(ref[pos], &s);
+ for (j = 0; j < bca->indelreg; ++j) kputc(ref[pos+1+j], &s);
+ kputc('\0', &s);
+ // write ALT
+ kputc(ref[pos], &s);
+ for (i = 1; i < 4; ++i) {
+ if (bc->a[i] < 0) break;
+ if (i > 1) {
+ kputc(',', &s); kputc(ref[pos], &s);
+ }
+ if (bca->indel_types[bc->a[i]] < 0) { // deletion
+ for (j = -bca->indel_types[bc->a[i]]; j < bca->indelreg; ++j)
+ kputc(ref[pos+1+j], &s);
+ } else { // insertion; cannot be a reference unless a bug
+ char *inscns = &bca->inscns[bc->a[i] * bca->maxins];
+ for (j = 0; j < bca->indel_types[bc->a[i]]; ++j)
+ kputc("ACGTN"[(int)inscns[j]], &s);
+ for (j = 0; j < bca->indelreg; ++j) kputc(ref[pos+1+j], &s);
+ }
+ }
+ kputc('\0', &s);
+ } else { // a SNP
+ kputc("ACGTN"[bc->ori_ref], &s); kputc('\0', &s);
+ for (i = 1; i < 5; ++i) {
+ if (bc->a[i] < 0) break;
+ if (i > 1) kputc(',', &s);
+ kputc(bc->unseen == i? 'X' : "ACGT"[bc->a[i]], &s);
+ }
+ kputc('\0', &s);
+ }
+ kputc('\0', &s);
+ // INFO
+ if (bc->ori_ref < 0) kputs("INDEL;", &s);
+ kputs("DP=", &s); kputw(bc->ori_depth, &s); kputs(";I16=", &s);
+ for (i = 0; i < 16; ++i) {
+ if (i) kputc(',', &s);
+ kputw(bc->anno[i], &s);
+ }
+ kputc('\0', &s);
+ // FMT
+ kputs("PL", &s);
+ if (bcr) {
+ kputs(":DP", &s);
+ if (is_SP) kputs(":SP", &s);
+ }
+ kputc('\0', &s);
+ b->m_str = s.m; b->str = s.s; b->l_str = s.l;
+ bcf_sync(b);
+ memcpy(b->gi[0].data, bc->PL, b->gi[0].len * bc->n);
+ if (bcr) {
+ uint16_t *dp = (uint16_t*)b->gi[1].data;
+ uint8_t *sp = is_SP? b->gi[2].data : 0;
+ for (i = 0; i < bc->n; ++i) {
+ bcf_callret1_t *p = bcr + i;
+ dp[i] = p->depth < 0xffff? p->depth : 0xffff;
+ if (is_SP) {
+ if (p->anno[0] + p->anno[1] < 2 || p->anno[2] + p->anno[3] < 2
+ || p->anno[0] + p->anno[2] < 2 || p->anno[1] + p->anno[3] < 2)
+ {
+ sp[i] = 0;
+ } else {
+ double left, right, two;
+ int x;
+ kt_fisher_exact(p->anno[0], p->anno[1], p->anno[2], p->anno[3], &left, &right, &two);
+ x = (int)(-4.343 * log(two) + .499);
+ if (x > 255) x = 255;
+ sp[i] = x;
+ }
+ }
+ }
+ }
+ return 0;
+}
--- /dev/null
+#ifndef BAM2BCF_H
+#define BAM2BCF_H
+
+#include <stdint.h>
+#include "errmod.h"
+#include "bcftools/bcf.h"
+
+#define B2B_INDEL_NULL 10000
+
+typedef struct __bcf_callaux_t {
+ int capQ, min_baseQ;
+ int openQ, extQ, tandemQ; // for indels
+ int min_support; // for collecting indel candidates
+ double min_frac; // for collecting indel candidates
+ // for internal uses
+ int max_bases;
+ int indel_types[4];
+ int maxins, indelreg;
+ char *inscns;
+ uint16_t *bases;
+ errmod_t *e;
+ void *rghash;
+} bcf_callaux_t;
+
+typedef struct {
+ int depth, ori_depth, qsum[4];
+ int anno[16];
+ float p[25];
+} bcf_callret1_t;
+
+typedef struct {
+ int a[5]; // alleles: ref, alt, alt2, alt3
+ int n, n_alleles, shift, ori_ref, unseen;
+ int anno[16], depth, ori_depth;
+ uint8_t *PL;
+} bcf_call_t;
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ bcf_callaux_t *bcf_call_init(double theta, int min_baseQ);
+ void bcf_call_destroy(bcf_callaux_t *bca);
+ int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base, bcf_callaux_t *bca, bcf_callret1_t *r);
+ int bcf_call_combine(int n, const bcf_callret1_t *calls, int ref_base /*4-bit*/, bcf_call_t *call);
+ int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b, bcf_callret1_t *bcr, int is_SP,
+ const bcf_callaux_t *bca, const char *ref);
+ int bcf_call_gap_prep(int n, int *n_plp, bam_pileup1_t **plp, int pos, bcf_callaux_t *bca, const char *ref,
+ const void *rghash);
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif
--- /dev/null
+#include "pysam.h"
+
+#include <assert.h>
+#include <ctype.h>
+#include <string.h>
+#include "bam.h"
+#include "bam2bcf.h"
+#include "ksort.h"
+#include "kaln.h"
+#include "kprobaln.h"
+#include "khash.h"
+KHASH_SET_INIT_STR(rg)
+
+#define MINUS_CONST 0x10000000
+#define INDEL_WINDOW_SIZE 50
+
+void *bcf_call_add_rg(void *_hash, const char *hdtext, const char *list)
+{
+ const char *s, *p, *q, *r, *t;
+ khash_t(rg) *hash;
+ if (list == 0 || hdtext == 0) return _hash;
+ if (_hash == 0) _hash = kh_init(rg);
+ hash = (khash_t(rg)*)_hash;
+ if ((s = strstr(hdtext, "@RG\t")) == 0) return hash;
+ do {
+ t = strstr(s + 4, "@RG\t"); // the next @RG
+ if ((p = strstr(s, "\tID:")) != 0) p += 4;
+ if ((q = strstr(s, "\tPL:")) != 0) q += 4;
+ if (p && q && (t == 0 || (p < t && q < t))) { // ID and PL are both present
+ int lp, lq;
+ char *x;
+ for (r = p; *r && *r != '\t' && *r != '\n'; ++r); lp = r - p;
+ for (r = q; *r && *r != '\t' && *r != '\n'; ++r); lq = r - q;
+ x = calloc((lp > lq? lp : lq) + 1, 1);
+ for (r = q; *r && *r != '\t' && *r != '\n'; ++r) x[r-q] = *r;
+ if (strstr(list, x)) { // insert ID to the hash table
+ khint_t k;
+ int ret;
+ for (r = p; *r && *r != '\t' && *r != '\n'; ++r) x[r-p] = *r;
+ x[r-p] = 0;
+ k = kh_get(rg, hash, x);
+ if (k == kh_end(hash)) k = kh_put(rg, hash, x, &ret);
+ else free(x);
+ } else free(x);
+ }
+ s = t;
+ } while (s);
+ return hash;
+}
+
+void bcf_call_del_rghash(void *_hash)
+{
+ khint_t k;
+ khash_t(rg) *hash = (khash_t(rg)*)_hash;
+ if (hash == 0) return;
+ for (k = kh_begin(hash); k < kh_end(hash); ++k)
+ if (kh_exist(hash, k))
+ free((char*)kh_key(hash, k));
+ kh_destroy(rg, hash);
+}
+
+static int tpos2qpos(const bam1_core_t *c, const uint32_t *cigar, int32_t tpos, int is_left, int32_t *_tpos)
+{
+ int k, x = c->pos, y = 0, last_y = 0;
+ *_tpos = c->pos;
+ for (k = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k] & BAM_CIGAR_MASK;
+ int l = cigar[k] >> BAM_CIGAR_SHIFT;
+ if (op == BAM_CMATCH) {
+ if (c->pos > tpos) return y;
+ if (x + l > tpos) {
+ *_tpos = tpos;
+ return y + (tpos - x);
+ }
+ x += l; y += l;
+ last_y = y;
+ } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
+ else if (op == BAM_CDEL || op == BAM_CREF_SKIP) {
+ if (x + l > tpos) {
+ *_tpos = is_left? x : x + l;
+ return y;
+ }
+ x += l;
+ }
+ }
+ *_tpos = x;
+ return last_y;
+}
+// FIXME: check if the inserted sequence is consistent with the homopolymer run
+// l is the relative gap length and l_run is the length of the homopolymer on the reference
+static inline int est_seqQ(const bcf_callaux_t *bca, int l, int l_run)
+{
+ int q, qh;
+ q = bca->openQ + bca->extQ * (abs(l) - 1);
+ qh = l_run >= 3? (int)(bca->tandemQ * (double)abs(l) / l_run + .499) : 1000;
+ return q < qh? q : qh;
+}
+
+static inline int est_indelreg(int pos, const char *ref, int l, char *ins4)
+{
+ int i, j, max = 0, max_i = pos, score = 0;
+ l = abs(l);
+ for (i = pos + 1, j = 0; ref[i]; ++i, ++j) {
+ if (ins4) score += (toupper(ref[i]) != "ACGTN"[(int)ins4[j%l]])? -10 : 1;
+ else score += (toupper(ref[i]) != toupper(ref[pos+1+j%l]))? -10 : 1;
+ if (score < 0) break;
+ if (max < score) max = score, max_i = i;
+ }
+ return max_i - pos;
+}
+
+int bcf_call_gap_prep(int n, int *n_plp, bam_pileup1_t **plp, int pos, bcf_callaux_t *bca, const char *ref,
+ const void *rghash)
+{
+ extern void ks_introsort_uint32_t(int, uint32_t*);
+ int i, s, j, k, t, n_types, *types, max_rd_len, left, right, max_ins, *score1, *score2, max_ref2;
+ int N, K, l_run, ref_type, n_alt;
+ char *inscns = 0, *ref2, *query, **ref_sample;
+ khash_t(rg) *hash = (khash_t(rg)*)rghash;
+ if (ref == 0 || bca == 0) return -1;
+ // mark filtered reads
+ if (rghash) {
+ N = 0;
+ for (s = N = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i) {
+ bam_pileup1_t *p = plp[s] + i;
+ const uint8_t *rg = bam_aux_get(p->b, "RG");
+ p->aux = 1; // filtered by default
+ if (rg) {
+ khint_t k = kh_get(rg, hash, (const char*)(rg + 1));
+ if (k != kh_end(hash)) p->aux = 0, ++N; // not filtered
+ }
+ }
+ }
+ if (N == 0) return -1; // no reads left
+ }
+ // determine if there is a gap
+ for (s = N = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i)
+ if (plp[s][i].indel != 0) break;
+ if (i < n_plp[s]) break;
+ }
+ if (s == n) return -1; // there is no indel at this position.
+ for (s = N = 0; s < n; ++s) N += n_plp[s]; // N is the total number of reads
+ { // find out how many types of indels are present
+ int m, n_alt = 0, n_tot = 0;
+ uint32_t *aux;
+ aux = calloc(N + 1, 4);
+ m = max_rd_len = 0;
+ aux[m++] = MINUS_CONST; // zero indel is always a type
+ for (s = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i) {
+ const bam_pileup1_t *p = plp[s] + i;
+ if (rghash == 0 || p->aux == 0) {
+ ++n_tot;
+ if (p->indel != 0) {
+ ++n_alt;
+ aux[m++] = MINUS_CONST + p->indel;
+ }
+ }
+ j = bam_cigar2qlen(&p->b->core, bam1_cigar(p->b));
+ if (j > max_rd_len) max_rd_len = j;
+ }
+ }
+ ks_introsort(uint32_t, m, aux);
+ // squeeze out identical types
+ for (i = 1, n_types = 1; i < m; ++i)
+ if (aux[i] != aux[i-1]) ++n_types;
+ if (n_types == 1 || (double)n_alt / n_tot < bca->min_frac || n_alt < bca->min_support) { // then skip
+ free(aux); return -1;
+ }
+ types = (int*)calloc(n_types, sizeof(int));
+ t = 0;
+ types[t++] = aux[0] - MINUS_CONST;
+ for (i = 1; i < m; ++i)
+ if (aux[i] != aux[i-1])
+ types[t++] = aux[i] - MINUS_CONST;
+ free(aux);
+ for (t = 0; t < n_types; ++t)
+ if (types[t] == 0) break;
+ ref_type = t; // the index of the reference type (0)
+ assert(n_types < 64);
+ }
+ { // calculate left and right boundary
+ left = pos > INDEL_WINDOW_SIZE? pos - INDEL_WINDOW_SIZE : 0;
+ right = pos + INDEL_WINDOW_SIZE;
+ if (types[0] < 0) right -= types[0];
+ // in case the alignments stand out the reference
+ for (i = pos; i < right; ++i)
+ if (ref[i] == 0) break;
+ right = i;
+ }
+ /* The following block fixes a long-existing flaw in the INDEL
+ * calling model: the interference of nearby SNPs. However, it also
+ * reduces the power because sometimes, substitutions caused by
+ * indels are not distinguishable from true mutations. Multiple
+ * sequence realignment helps to increase the power.
+ */
+ { // construct per-sample consensus
+ int L = right - left + 1, max_i, max2_i;
+ uint32_t *cns, max, max2;
+ char *ref0, *r;
+ ref_sample = calloc(n, sizeof(void*));
+ cns = calloc(L, 4);
+ ref0 = calloc(L, 1);
+ for (i = 0; i < right - left; ++i)
+ ref0[i] = bam_nt16_table[(int)ref[i+left]];
+ for (s = 0; s < n; ++s) {
+ r = ref_sample[s] = calloc(L, 1);
+ memset(cns, 0, sizeof(int) * L);
+ // collect ref and non-ref counts
+ for (i = 0; i < n_plp[s]; ++i) {
+ bam_pileup1_t *p = plp[s] + i;
+ bam1_t *b = p->b;
+ uint32_t *cigar = bam1_cigar(b);
+ uint8_t *seq = bam1_seq(b);
+ int x = b->core.pos, y = 0;
+ for (k = 0; k < b->core.n_cigar; ++k) {
+ int op = cigar[k]&0xf;
+ int j, l = cigar[k]>>4;
+ if (op == BAM_CMATCH) {
+ for (j = 0; j < l; ++j)
+ if (x + j >= left && x + j < right)
+ cns[x+j-left] += (bam1_seqi(seq, y+j) == ref0[x+j-left])? 1 : 0x10000;
+ x += l; y += l;
+ } else if (op == BAM_CDEL || op == BAM_CREF_SKIP) x += l;
+ else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
+ }
+ }
+ // determine the consensus
+ for (i = 0; i < right - left; ++i) r[i] = ref0[i];
+ max = max2 = 0; max_i = max2_i = -1;
+ for (i = 0; i < right - left; ++i) {
+ if (cns[i]>>16 >= max>>16) max2 = max, max2_i = max_i, max = cns[i], max_i = i;
+ else if (cns[i]>>16 >= max2>>16) max2 = cns[i], max2_i = i;
+ }
+ if ((double)(max&0xffff) / ((max&0xffff) + (max>>16)) >= 0.7) max_i = -1;
+ if ((double)(max2&0xffff) / ((max2&0xffff) + (max2>>16)) >= 0.7) max2_i = -1;
+ if (max_i >= 0) r[max_i] = 15;
+ if (max2_i >= 0) r[max2_i] = 15;
+// for (i = 0; i < right - left; ++i) fputc("=ACMGRSVTWYHKDBN"[(int)r[i]], pysamerr); fputc('\n', pysamerr);
+ }
+ free(ref0); free(cns);
+ }
+ { // the length of the homopolymer run around the current position
+ int c = bam_nt16_table[(int)ref[pos + 1]];
+ if (c == 15) l_run = 1;
+ else {
+ for (i = pos + 2; ref[i]; ++i)
+ if (bam_nt16_table[(int)ref[i]] != c) break;
+ l_run = i;
+ for (i = pos; i >= 0; --i)
+ if (bam_nt16_table[(int)ref[i]] != c) break;
+ l_run -= i + 1;
+ }
+ }
+ // construct the consensus sequence
+ max_ins = types[n_types - 1]; // max_ins is at least 0
+ if (max_ins > 0) {
+ int *inscns_aux = calloc(4 * n_types * max_ins, sizeof(int));
+ // count the number of occurrences of each base at each position for each type of insertion
+ for (t = 0; t < n_types; ++t) {
+ if (types[t] > 0) {
+ for (s = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i) {
+ bam_pileup1_t *p = plp[s] + i;
+ if (p->indel == types[t]) {
+ uint8_t *seq = bam1_seq(p->b);
+ for (k = 1; k <= p->indel; ++k) {
+ int c = bam_nt16_nt4_table[bam1_seqi(seq, p->qpos + k)];
+ if (c < 4) ++inscns_aux[(t*max_ins+(k-1))*4 + c];
+ }
+ }
+ }
+ }
+ }
+ }
+ // use the majority rule to construct the consensus
+ inscns = calloc(n_types * max_ins, 1);
+ for (t = 0; t < n_types; ++t) {
+ for (j = 0; j < types[t]; ++j) {
+ int max = 0, max_k = -1, *ia = &inscns_aux[(t*max_ins+j)*4];
+ for (k = 0; k < 4; ++k)
+ if (ia[k] > max)
+ max = ia[k], max_k = k;
+ inscns[t*max_ins + j] = max? max_k : 4;
+ }
+ }
+ free(inscns_aux);
+ }
+ // compute the likelihood given each type of indel for each read
+ max_ref2 = right - left + 2 + 2 * (max_ins > -types[0]? max_ins : -types[0]);
+ ref2 = calloc(max_ref2, 1);
+ query = calloc(right - left + max_rd_len + max_ins + 2, 1);
+ score1 = calloc(N * n_types, sizeof(int));
+ score2 = calloc(N * n_types, sizeof(int));
+ bca->indelreg = 0;
+ for (t = 0; t < n_types; ++t) {
+ int l, ir;
+ kpa_par_t apf1 = { 1e-4, 1e-2, 10 }, apf2 = { 1e-6, 1e-3, 10 };
+ apf1.bw = apf2.bw = abs(types[t]) + 3;
+ // compute indelreg
+ if (types[t] == 0) ir = 0;
+ else if (types[t] > 0) ir = est_indelreg(pos, ref, types[t], &inscns[t*max_ins]);
+ else ir = est_indelreg(pos, ref, -types[t], 0);
+ if (ir > bca->indelreg) bca->indelreg = ir;
+// fprintf(pysamerr, "%d, %d, %d\n", pos, types[t], ir);
+ // realignment
+ for (s = K = 0; s < n; ++s) {
+ // write ref2
+ for (k = 0, j = left; j <= pos; ++j)
+ ref2[k++] = bam_nt16_nt4_table[(int)ref_sample[s][j-left]];
+ if (types[t] <= 0) j += -types[t];
+ else for (l = 0; l < types[t]; ++l)
+ ref2[k++] = inscns[t*max_ins + l];
+ for (; j < right && ref[j]; ++j)
+ ref2[k++] = bam_nt16_nt4_table[(int)ref_sample[s][j-left]];
+ for (; k < max_ref2; ++k) ref2[k] = 4;
+ if (j < right) right = j;
+ // align each read to ref2
+ for (i = 0; i < n_plp[s]; ++i, ++K) {
+ bam_pileup1_t *p = plp[s] + i;
+ int qbeg, qend, tbeg, tend, sc, kk;
+ uint8_t *seq = bam1_seq(p->b);
+ uint32_t *cigar = bam1_cigar(p->b);
+ if (p->b->core.flag&4) continue; // unmapped reads
+ // FIXME: the following loop should be better moved outside; nonetheless, realignment should be much slower anyway.
+ for (kk = 0; kk < p->b->core.n_cigar; ++kk)
+ if ((cigar[kk]&BAM_CIGAR_MASK) == BAM_CREF_SKIP) break;
+ if (kk < p->b->core.n_cigar) continue;
+ // FIXME: the following skips soft clips, but using them may be more sensitive.
+ // determine the start and end of sequences for alignment
+ qbeg = tpos2qpos(&p->b->core, bam1_cigar(p->b), left, 0, &tbeg);
+ qend = tpos2qpos(&p->b->core, bam1_cigar(p->b), right, 1, &tend);
+ if (types[t] < 0) {
+ int l = -types[t];
+ tbeg = tbeg - l > left? tbeg - l : left;
+ }
+ // write the query sequence
+ for (l = qbeg; l < qend; ++l)
+ query[l - qbeg] = bam_nt16_nt4_table[bam1_seqi(seq, l)];
+ { // do realignment; this is the bottleneck
+ const uint8_t *qual = bam1_qual(p->b), *bq;
+ uint8_t *qq;
+ qq = calloc(qend - qbeg, 1);
+ bq = (uint8_t*)bam_aux_get(p->b, "ZQ");
+ if (bq) ++bq; // skip type
+ for (l = qbeg; l < qend; ++l) {
+ qq[l - qbeg] = bq? qual[l] + (bq[l] - 64) : qual[l];
+ if (qq[l - qbeg] > 30) qq[l - qbeg] = 30;
+ if (qq[l - qbeg] < 7) qq[l - qbeg] = 7;
+ }
+ sc = kpa_glocal((uint8_t*)ref2 + tbeg - left, tend - tbeg + abs(types[t]),
+ (uint8_t*)query, qend - qbeg, qq, &apf1, 0, 0);
+ l = (int)(100. * sc / (qend - qbeg) + .499); // used for adjusting indelQ below
+ if (l > 255) l = 255;
+ score1[K*n_types + t] = score2[K*n_types + t] = sc<<8 | l;
+ if (sc > 5) {
+ sc = kpa_glocal((uint8_t*)ref2 + tbeg - left, tend - tbeg + abs(types[t]),
+ (uint8_t*)query, qend - qbeg, qq, &apf2, 0, 0);
+ l = (int)(100. * sc / (qend - qbeg) + .499);
+ if (l > 255) l = 255;
+ score2[K*n_types + t] = sc<<8 | l;
+ }
+ free(qq);
+ }
+/*
+ for (l = 0; l < tend - tbeg + abs(types[t]); ++l)
+ fputc("ACGTN"[(int)ref2[tbeg-left+l]], pysamerr);
+ fputc('\n', pysamerr);
+ for (l = 0; l < qend - qbeg; ++l) fputc("ACGTN"[(int)query[l]], pysamerr);
+ fputc('\n', pysamerr);
+ fprintf(pysamerr, "pos=%d type=%d read=%d:%d name=%s qbeg=%d tbeg=%d score=%d\n", pos, types[t], s, i, bam1_qname(p->b), qbeg, tbeg, sc);
+*/
+ }
+ }
+ }
+ free(ref2); free(query);
+ { // compute indelQ
+ int *sc, tmp, *sumq;
+ sc = alloca(n_types * sizeof(int));
+ sumq = alloca(n_types * sizeof(int));
+ memset(sumq, 0, sizeof(int) * n_types);
+ for (s = K = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i, ++K) {
+ bam_pileup1_t *p = plp[s] + i;
+ int *sct = &score1[K*n_types], indelQ1, indelQ2, seqQ, indelQ;
+ for (t = 0; t < n_types; ++t) sc[t] = sct[t]<<6 | t;
+ for (t = 1; t < n_types; ++t) // insertion sort
+ for (j = t; j > 0 && sc[j] < sc[j-1]; --j)
+ tmp = sc[j], sc[j] = sc[j-1], sc[j-1] = tmp;
+ /* errmod_cal() assumes that if the call is wrong, the
+ * likelihoods of other events are equal. This is about
+ * right for substitutions, but is not desired for
+ * indels. To reuse errmod_cal(), I have to make
+ * compromise for multi-allelic indels.
+ */
+ if ((sc[0]&0x3f) == ref_type) {
+ indelQ1 = (sc[1]>>14) - (sc[0]>>14);
+ seqQ = est_seqQ(bca, types[sc[1]&0x3f], l_run);
+ } else {
+ for (t = 0; t < n_types; ++t) // look for the reference type
+ if ((sc[t]&0x3f) == ref_type) break;
+ indelQ1 = (sc[t]>>14) - (sc[0]>>14);
+ seqQ = est_seqQ(bca, types[sc[0]&0x3f], l_run);
+ }
+ tmp = sc[0]>>6 & 0xff;
+ indelQ1 = tmp > 111? 0 : (int)((1. - tmp/111.) * indelQ1 + .499); // reduce indelQ
+ sct = &score2[K*n_types];
+ for (t = 0; t < n_types; ++t) sc[t] = sct[t]<<6 | t;
+ for (t = 1; t < n_types; ++t) // insertion sort
+ for (j = t; j > 0 && sc[j] < sc[j-1]; --j)
+ tmp = sc[j], sc[j] = sc[j-1], sc[j-1] = tmp;
+ if ((sc[0]&0x3f) == ref_type) {
+ indelQ2 = (sc[1]>>14) - (sc[0]>>14);
+ } else {
+ for (t = 0; t < n_types; ++t) // look for the reference type
+ if ((sc[t]&0x3f) == ref_type) break;
+ indelQ2 = (sc[t]>>14) - (sc[0]>>14);
+ }
+ tmp = sc[0]>>6 & 0xff;
+ indelQ2 = tmp > 111? 0 : (int)((1. - tmp/111.) * indelQ2 + .499);
+ // pick the smaller between indelQ1 and indelQ2
+ indelQ = indelQ1 < indelQ2? indelQ1 : indelQ2;
+ if (indelQ > 255) indelQ = 255;
+ if (seqQ > 255) seqQ = 255;
+ p->aux = (sc[0]&0x3f)<<16 | seqQ<<8 | indelQ; // use 22 bits in total
+ sumq[sc[0]&0x3f] += indelQ < seqQ? indelQ : seqQ;
+// fprintf(pysamerr, "pos=%d read=%d:%d name=%s call=%d indelQ=%d seqQ=%d\n", pos, s, i, bam1_qname(p->b), types[sc[0]&0x3f], indelQ, seqQ);
+ }
+ }
+ // determine bca->indel_types[] and bca->inscns
+ bca->maxins = max_ins;
+ bca->inscns = realloc(bca->inscns, bca->maxins * 4);
+ for (t = 0; t < n_types; ++t)
+ sumq[t] = sumq[t]<<6 | t;
+ for (t = 1; t < n_types; ++t) // insertion sort
+ for (j = t; j > 0 && sumq[j] > sumq[j-1]; --j)
+ tmp = sumq[j], sumq[j] = sumq[j-1], sumq[j-1] = tmp;
+ for (t = 0; t < n_types; ++t) // look for the reference type
+ if ((sumq[t]&0x3f) == ref_type) break;
+ if (t) { // then move the reference type to the first
+ tmp = sumq[t];
+ for (; t > 0; --t) sumq[t] = sumq[t-1];
+ sumq[0] = tmp;
+ }
+ for (t = 0; t < 4; ++t) bca->indel_types[t] = B2B_INDEL_NULL;
+ for (t = 0; t < 4 && t < n_types; ++t) {
+ bca->indel_types[t] = types[sumq[t]&0x3f];
+ memcpy(&bca->inscns[t * bca->maxins], &inscns[(sumq[t]&0x3f) * max_ins], bca->maxins);
+ }
+ // update p->aux
+ for (s = n_alt = 0; s < n; ++s) {
+ for (i = 0; i < n_plp[s]; ++i) {
+ bam_pileup1_t *p = plp[s] + i;
+ int x = types[p->aux>>16&0x3f];
+ for (j = 0; j < 4; ++j)
+ if (x == bca->indel_types[j]) break;
+ p->aux = j<<16 | (j == 4? 0 : (p->aux&0xffff));
+ if ((p->aux>>16&0x3f) > 0) ++n_alt;
+// fprintf(pysamerr, "X pos=%d read=%d:%d name=%s call=%d type=%d q=%d seqQ=%d\n", pos, s, i, bam1_qname(p->b), p->aux>>16&63, bca->indel_types[p->aux>>16&63], p->aux&0xff, p->aux>>8&0xff);
+ }
+ }
+ }
+ free(score1); free(score2);
+ // free
+ for (i = 0; i < n; ++i) free(ref_sample[i]);
+ free(ref_sample);
+ free(types); free(inscns);
+ return n_alt > 0? 0 : -1;
+}
--- /dev/null
+#include "pysam.h"
+
+/* This program demonstrates how to generate pileup from multiple BAMs
+ * simutaneously, to achieve random access and to use the BED interface.
+ * To compile this program separately, you may:
+ *
+ * gcc -g -O2 -Wall -o bam2depth -D_MAIN_BAM2DEPTH bam2depth.c -L. -lbam -lz
+ */
+#include <stdlib.h>
+#include <string.h>
+#include <stdio.h>
+#include <unistd.h>
+#include "bam.h"
+
+typedef struct { // auxiliary data structure
+ bamFile fp; // the file handler
+ bam_iter_t iter; // NULL if a region not specified
+ int min_mapQ; // mapQ filter
+} aux_t;
+
+void *bed_read(const char *fn); // read a BED or position list file
+void bed_destroy(void *_h); // destroy the BED data structure
+int bed_overlap(const void *_h, const char *chr, int beg, int end); // test if chr:beg-end overlaps
+
+// This function reads a BAM alignment from one BAM file.
+static int read_bam(void *data, bam1_t *b) // read level filters better go here to avoid pileup
+{
+ aux_t *aux = (aux_t*)data; // data in fact is a pointer to an auxiliary structure
+ int ret = aux->iter? bam_iter_read(aux->fp, aux->iter, b) : bam_read1(aux->fp, b);
+ if ((int)b->core.qual < aux->min_mapQ) b->core.flag |= BAM_FUNMAP;
+ return ret;
+}
+
+#ifdef _MAIN_BAM2DEPTH
+int main(int argc, char *argv[])
+#else
+int main_depth(int argc, char *argv[])
+#endif
+{
+ int i, n, tid, beg, end, pos, *n_plp, baseQ = 0, mapQ = 0;
+ const bam_pileup1_t **plp;
+ char *reg = 0; // specified region
+ void *bed = 0; // BED data structure
+ bam_header_t *h = 0; // BAM header of the 1st input
+ aux_t **data;
+ bam_mplp_t mplp;
+
+ // parse the command line
+ while ((n = getopt(argc, argv, "r:b:q:Q:")) >= 0) {
+ switch (n) {
+ case 'r': reg = strdup(optarg); break; // parsing a region requires a BAM header
+ case 'b': bed = bed_read(optarg); break; // BED or position list file can be parsed now
+ case 'q': baseQ = atoi(optarg); break; // base quality threshold
+ case 'Q': mapQ = atoi(optarg); break; // mapping quality threshold
+ }
+ }
+ if (optind == argc) {
+ fprintf(pysamerr, "Usage: bam2depth [-r reg] [-q baseQthres] [-Q mapQthres] [-b in.bed] <in1.bam> [...]\n");
+ return 1;
+ }
+
+ // initialize the auxiliary data structures
+ n = argc - optind; // the number of BAMs on the command line
+ data = calloc(n, sizeof(void*)); // data[i] for the i-th input
+ beg = 0; end = 1<<30; tid = -1; // set the default region
+ for (i = 0; i < n; ++i) {
+ bam_header_t *htmp;
+ data[i] = calloc(1, sizeof(aux_t));
+ data[i]->fp = bam_open(argv[optind+i], "r"); // open BAM
+ data[i]->min_mapQ = mapQ; // set the mapQ filter
+ htmp = bam_header_read(data[i]->fp); // read the BAM header
+ if (i == 0) {
+ h = htmp; // keep the header of the 1st BAM
+ if (reg) bam_parse_region(h, reg, &tid, &beg, &end); // also parse the region
+ } else bam_header_destroy(htmp); // if not the 1st BAM, trash the header
+ if (tid >= 0) { // if a region is specified and parsed successfully
+ bam_index_t *idx = bam_index_load(argv[optind+i]); // load the index
+ data[i]->iter = bam_iter_query(idx, tid, beg, end); // set the iterator
+ bam_index_destroy(idx); // the index is not needed any more; phase out of the memory
+ }
+ }
+
+ // the core multi-pileup loop
+ mplp = bam_mplp_init(n, read_bam, (void**)data); // initialization
+ n_plp = calloc(n, sizeof(int)); // n_plp[i] is the number of covering reads from the i-th BAM
+ plp = calloc(n, sizeof(void*)); // plp[i] points to the array of covering reads (internal in mplp)
+ while (bam_mplp_auto(mplp, &tid, &pos, n_plp, plp) > 0) { // come to the next covered position
+ if (pos < beg || pos >= end) continue; // out of range; skip
+ if (bed && bed_overlap(bed, h->target_name[tid], pos, pos + 1) == 0) continue; // not in BED; skip
+ fputs(h->target_name[tid], stdout); printf("\t%d", pos+1); // a customized printf() would be faster
+ for (i = 0; i < n; ++i) { // base level filters have to go here
+ int j, m = 0;
+ for (j = 0; j < n_plp[i]; ++j) {
+ const bam_pileup1_t *p = plp[i] + j; // DON'T modfity plp[][] unless you really know
+ if (p->is_del || p->is_refskip) ++m; // having dels or refskips at tid:pos
+ else if (bam1_qual(p->b)[p->qpos] < baseQ) ++m; // low base quality
+ }
+ printf("\t%d", n_plp[i] - m); // this the depth to output
+ }
+ putchar('\n');
+ }
+ free(n_plp); free(plp);
+ bam_mplp_destroy(mplp);
+
+ bam_header_destroy(h);
+ for (i = 0; i < n; ++i) {
+ bam_close(data[i]->fp);
+ if (data[i]->iter) bam_iter_destroy(data[i]->iter);
+ free(data[i]);
+ }
+ free(data); free(reg);
+ if (bed) bed_destroy(bed);
+ return 0;
+}
+++ /dev/null
-#include <ctype.h>
-#include "bam.h"
-#include "khash.h"
-typedef char *str_p;
-KHASH_MAP_INIT_STR(s, int)
-KHASH_MAP_INIT_STR(r2l, str_p)
-
-void bam_aux_append(bam1_t *b, const char tag[2], char type, int len, uint8_t *data)
-{
- int ori_len = b->data_len;
- b->data_len += 3 + len;
- b->l_aux += 3 + len;
- if (b->m_data < b->data_len) {
- b->m_data = b->data_len;
- kroundup32(b->m_data);
- b->data = (uint8_t*)realloc(b->data, b->m_data);
- }
- b->data[ori_len] = tag[0]; b->data[ori_len + 1] = tag[1];
- b->data[ori_len + 2] = type;
- memcpy(b->data + ori_len + 3, data, len);
-}
-
-uint8_t *bam_aux_get_core(bam1_t *b, const char tag[2])
-{
- return bam_aux_get(b, tag);
-}
-
-#define __skip_tag(s) do { \
- int type = toupper(*(s)); \
- ++(s); \
- if (type == 'C' || type == 'A') ++(s); \
- else if (type == 'S') (s) += 2; \
- else if (type == 'I' || type == 'F') (s) += 4; \
- else if (type == 'D') (s) += 8; \
- else if (type == 'Z' || type == 'H') { while (*(s)) ++(s); ++(s); } \
- } while (0)
-
-uint8_t *bam_aux_get(const bam1_t *b, const char tag[2])
-{
- uint8_t *s;
- int y = tag[0]<<8 | tag[1];
- s = bam1_aux(b);
- while (s < b->data + b->data_len) {
- int x = (int)s[0]<<8 | s[1];
- s += 2;
- if (x == y) return s;
- __skip_tag(s);
- }
- return 0;
-}
-// s MUST BE returned by bam_aux_get()
-int bam_aux_del(bam1_t *b, uint8_t *s)
-{
- uint8_t *p, *aux;
- aux = bam1_aux(b);
- p = s - 2;
- __skip_tag(s);
- memmove(p, s, b->l_aux - (s - aux));
- b->data_len -= s - p;
- b->l_aux -= s - p;
- return 0;
-}
-
-void bam_init_header_hash(bam_header_t *header)
-{
- if (header->hash == 0) {
- int ret, i;
- khiter_t iter;
- khash_t(s) *h;
- header->hash = h = kh_init(s);
- for (i = 0; i < header->n_targets; ++i) {
- iter = kh_put(s, h, header->target_name[i], &ret);
- kh_value(h, iter) = i;
- }
- }
-}
-
-void bam_destroy_header_hash(bam_header_t *header)
-{
- if (header->hash)
- kh_destroy(s, (khash_t(s)*)header->hash);
-}
-
-int32_t bam_get_tid(const bam_header_t *header, const char *seq_name)
-{
- khint_t k;
- khash_t(s) *h = (khash_t(s)*)header->hash;
- k = kh_get(s, h, seq_name);
- return k == kh_end(h)? -1 : kh_value(h, k);
-}
-
-int bam_parse_region(bam_header_t *header, const char *str, int *ref_id, int *begin, int *end)
-{
- char *s, *p;
- int i, l, k;
- khiter_t iter;
- khash_t(s) *h;
-
- bam_init_header_hash(header);
- h = (khash_t(s)*)header->hash;
-
- l = strlen(str);
- p = s = (char*)malloc(l+1);
- /* squeeze out "," */
- for (i = k = 0; i != l; ++i)
- if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
- s[k] = 0;
- for (i = 0; i != k; ++i) if (s[i] == ':') break;
- s[i] = 0;
- iter = kh_get(s, h, s); /* get the ref_id */
- if (iter == kh_end(h)) { // name not found
- *ref_id = -1; free(s);
- return -1;
- }
- *ref_id = kh_value(h, iter);
- if (i == k) { /* dump the whole sequence */
- *begin = 0; *end = 1<<29; free(s);
- return 0;
- }
- for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
- *begin = atoi(p);
- if (i < k) {
- p = s + i + 1;
- *end = atoi(p);
- } else *end = 1<<29;
- if (*begin > 0) --*begin;
- free(s);
- if (*begin > *end) {
- fprintf(stderr, "[bam_parse_region] invalid region.\n");
- return -1;
- }
- return 0;
-}
-
-int32_t bam_aux2i(const uint8_t *s)
-{
- int type;
- if (s == 0) return 0;
- type = *s++;
- if (type == 'c') return (int32_t)*(int8_t*)s;
- else if (type == 'C') return (int32_t)*(uint8_t*)s;
- else if (type == 's') return (int32_t)*(int16_t*)s;
- else if (type == 'S') return (int32_t)*(uint16_t*)s;
- else if (type == 'i' || type == 'I') return *(int32_t*)s;
- else return 0;
-}
-
-float bam_aux2f(const uint8_t *s)
-{
- int type;
- type = *s++;
- if (s == 0) return 0.0;
- if (type == 'f') return *(float*)s;
- else return 0.0;
-}
-
-double bam_aux2d(const uint8_t *s)
-{
- int type;
- type = *s++;
- if (s == 0) return 0.0;
- if (type == 'd') return *(double*)s;
- else return 0.0;
-}
-
-char bam_aux2A(const uint8_t *s)
-{
- int type;
- type = *s++;
- if (s == 0) return 0;
- if (type == 'A') return *(char*)s;
- else return 0;
-}
-
-char *bam_aux2Z(const uint8_t *s)
-{
- int type;
- type = *s++;
- if (s == 0) return 0;
- if (type == 'Z' || type == 'H') return (char*)s;
- else return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <ctype.h>
+#include "bam.h"
+#include "khash.h"
+typedef char *str_p;
+KHASH_MAP_INIT_STR(s, int)
+KHASH_MAP_INIT_STR(r2l, str_p)
+
+void bam_aux_append(bam1_t *b, const char tag[2], char type, int len, uint8_t *data)
+{
+ int ori_len = b->data_len;
+ b->data_len += 3 + len;
+ b->l_aux += 3 + len;
+ if (b->m_data < b->data_len) {
+ b->m_data = b->data_len;
+ kroundup32(b->m_data);
+ b->data = (uint8_t*)realloc(b->data, b->m_data);
+ }
+ b->data[ori_len] = tag[0]; b->data[ori_len + 1] = tag[1];
+ b->data[ori_len + 2] = type;
+ memcpy(b->data + ori_len + 3, data, len);
+}
+
+uint8_t *bam_aux_get_core(bam1_t *b, const char tag[2])
+{
+ return bam_aux_get(b, tag);
+}
+
+#define __skip_tag(s) do { \
+ int type = toupper(*(s)); \
+ ++(s); \
+ if (type == 'Z' || type == 'H') { while (*(s)) ++(s); ++(s); } \
+ else if (type == 'B') (s) += 5 + bam_aux_type2size(*(s)) * (*(int32_t*)((s)+1)); \
+ else (s) += bam_aux_type2size(type); \
+ } while(0)
+
+uint8_t *bam_aux_get(const bam1_t *b, const char tag[2])
+{
+ uint8_t *s;
+ int y = tag[0]<<8 | tag[1];
+ s = bam1_aux(b);
+ while (s < b->data + b->data_len) {
+ int x = (int)s[0]<<8 | s[1];
+ s += 2;
+ if (x == y) return s;
+ __skip_tag(s);
+ }
+ return 0;
+}
+// s MUST BE returned by bam_aux_get()
+int bam_aux_del(bam1_t *b, uint8_t *s)
+{
+ uint8_t *p, *aux;
+ aux = bam1_aux(b);
+ p = s - 2;
+ __skip_tag(s);
+ memmove(p, s, b->l_aux - (s - aux));
+ b->data_len -= s - p;
+ b->l_aux -= s - p;
+ return 0;
+}
+
+void bam_init_header_hash(bam_header_t *header)
+{
+ if (header->hash == 0) {
+ int ret, i;
+ khiter_t iter;
+ khash_t(s) *h;
+ header->hash = h = kh_init(s);
+ for (i = 0; i < header->n_targets; ++i) {
+ iter = kh_put(s, h, header->target_name[i], &ret);
+ kh_value(h, iter) = i;
+ }
+ }
+}
+
+void bam_destroy_header_hash(bam_header_t *header)
+{
+ if (header->hash)
+ kh_destroy(s, (khash_t(s)*)header->hash);
+}
+
+int32_t bam_get_tid(const bam_header_t *header, const char *seq_name)
+{
+ khint_t k;
+ khash_t(s) *h = (khash_t(s)*)header->hash;
+ k = kh_get(s, h, seq_name);
+ return k == kh_end(h)? -1 : kh_value(h, k);
+}
+
+int bam_parse_region(bam_header_t *header, const char *str, int *ref_id, int *begin, int *end)
+{
+ char *s, *p;
+ int i, l, k;
+ khiter_t iter;
+ khash_t(s) *h;
+
+ bam_init_header_hash(header);
+ h = (khash_t(s)*)header->hash;
+
+ l = strlen(str);
+ p = s = (char*)malloc(l+1);
+ /* squeeze out "," */
+ for (i = k = 0; i != l; ++i)
+ if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
+ s[k] = 0;
+ for (i = 0; i != k; ++i) if (s[i] == ':') break;
+ s[i] = 0;
+ iter = kh_get(s, h, s); /* get the ref_id */
+ if (iter == kh_end(h)) { // name not found
+ *ref_id = -1; free(s);
+ return -1;
+ }
+ *ref_id = kh_value(h, iter);
+ if (i == k) { /* dump the whole sequence */
+ *begin = 0; *end = 1<<29; free(s);
+ return 0;
+ }
+ for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
+ *begin = atoi(p);
+ if (i < k) {
+ p = s + i + 1;
+ *end = atoi(p);
+ } else *end = 1<<29;
+ if (*begin > 0) --*begin;
+ free(s);
+ if (*begin > *end) {
+ fprintf(pysamerr, "[bam_parse_region] invalid region.\n");
+ return -1;
+ }
+ return 0;
+}
+
+int32_t bam_aux2i(const uint8_t *s)
+{
+ int type;
+ if (s == 0) return 0;
+ type = *s++;
+ if (type == 'c') return (int32_t)*(int8_t*)s;
+ else if (type == 'C') return (int32_t)*(uint8_t*)s;
+ else if (type == 's') return (int32_t)*(int16_t*)s;
+ else if (type == 'S') return (int32_t)*(uint16_t*)s;
+ else if (type == 'i' || type == 'I') return *(int32_t*)s;
+ else return 0;
+}
+
+float bam_aux2f(const uint8_t *s)
+{
+ int type;
+ type = *s++;
+ if (s == 0) return 0.0;
+ if (type == 'f') return *(float*)s;
+ else return 0.0;
+}
+
+double bam_aux2d(const uint8_t *s)
+{
+ int type;
+ type = *s++;
+ if (s == 0) return 0.0;
+ if (type == 'd') return *(double*)s;
+ else return 0.0;
+}
+
+char bam_aux2A(const uint8_t *s)
+{
+ int type;
+ type = *s++;
+ if (s == 0) return 0;
+ if (type == 'A') return *(char*)s;
+ else return 0;
+}
+
+char *bam_aux2Z(const uint8_t *s)
+{
+ int type;
+ type = *s++;
+ if (s == 0) return 0;
+ if (type == 'Z' || type == 'H') return (char*)s;
+ else return 0;
+}
+
+#ifdef _WIN32
+double drand48()
+{
+ return (double)rand() / RAND_MAX;
+}
+#endif
--- /dev/null
+#include "pysam.h"
+
+/*\r
+\r
+bam_cat -- efficiently concatenates bam files\r
+\r
+bam_cat can be used to concatenate BAM files. Under special\r
+circumstances, it can be used as an alternative to 'samtools merge' to\r
+concatenate multiple sorted files into a single sorted file. For this\r
+to work each file must be sorted, and the sorted files must be given\r
+as command line arguments in order such that the final read in file i\r
+is less than or equal to the first read in file i+1.\r
+\r
+This code is derived from the bam_reheader function in samtools 0.1.8\r
+and modified to perform concatenation by Chris Saunders on behalf of\r
+Illumina.\r
+\r
+\r
+########## License:\r
+\r
+The MIT License\r
+\r
+Original SAMtools work copyright (c) 2008-2009 Genome Research Ltd.\r
+Modified SAMtools work copyright (c) 2010 Illumina, Inc.\r
+\r
+Permission is hereby granted, free of charge, to any person obtaining a copy\r
+of this software and associated documentation files (the "Software"), to deal\r
+in the Software without restriction, including without limitation the rights\r
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell\r
+copies of the Software, and to permit persons to whom the Software is\r
+furnished to do so, subject to the following conditions:\r
+\r
+The above copyright notice and this permission notice shall be included in\r
+all copies or substantial portions of the Software.\r
+\r
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR\r
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,\r
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE\r
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER\r
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,\r
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN\r
+THE SOFTWARE.\r
+\r
+*/\r
+\r
+\r
+/*\r
+makefile:\r
+"""\r
+CC=gcc\r
+CFLAGS+=-g -Wall -O2 -D_FILE_OFFSET_BITS=64 -D_USE_KNETFILE -I$(SAMTOOLS_DIR)\r
+LDFLAGS+=-L$(SAMTOOLS_DIR)\r
+LDLIBS+=-lbam -lz\r
+\r
+all:bam_cat\r
+"""\r
+*/\r
+\r
+\r
+#include <stdio.h>\r
+#include <stdlib.h>\r
+#include <unistd.h>\r
+\r
+#include "bgzf.h"\r
+#include "bam.h"\r
+\r
+#define BUF_SIZE 0x10000\r
+\r
+#define GZIPID1 31\r
+#define GZIPID2 139\r
+\r
+#define BGZF_EMPTY_BLOCK_SIZE 28\r
+\r
+\r
+int bam_cat(int nfn, char * const *fn, const bam_header_t *h, const char* outbam)\r
+{\r
+ BGZF *fp;\r
+ FILE* fp_file;\r
+ uint8_t *buf;\r
+ uint8_t ebuf[BGZF_EMPTY_BLOCK_SIZE];\r
+ const int es=BGZF_EMPTY_BLOCK_SIZE;\r
+ int i;\r
+ \r
+ fp = strcmp(outbam, "-")? bgzf_open(outbam, "w") : bgzf_fdopen(fileno(stdout), "w");\r
+ if (fp == 0) {\r
+ fprintf(pysamerr, "[%s] ERROR: fail to open output file '%s'.\n", __func__, outbam);\r
+ return 1;\r
+ }\r
+ if (h) bam_header_write(fp, h);\r
+ \r
+ buf = (uint8_t*) malloc(BUF_SIZE);\r
+ for(i = 0; i < nfn; ++i){\r
+ BGZF *in;\r
+ bam_header_t *old;\r
+ int len,j;\r
+ \r
+ in = strcmp(fn[i], "-")? bam_open(fn[i], "r") : bam_dopen(fileno(stdin), "r");\r
+ if (in == 0) {\r
+ fprintf(pysamerr, "[%s] ERROR: fail to open file '%s'.\n", __func__, fn[i]);\r
+ return -1;\r
+ }\r
+ if (in->open_mode != 'r') return -1;\r
+ \r
+ old = bam_header_read(in);\r
+ if (h == 0 && i == 0) bam_header_write(fp, old);\r
+ \r
+ if (in->block_offset < in->block_length) {\r
+ bgzf_write(fp, in->uncompressed_block + in->block_offset, in->block_length - in->block_offset);\r
+ bgzf_flush(fp);\r
+ }\r
+ \r
+ j=0;\r
+#ifdef _USE_KNETFILE\r
+ fp_file=fp->x.fpw;\r
+ while ((len = knet_read(in->x.fpr, buf, BUF_SIZE)) > 0) {\r
+#else \r
+ fp_file=fp->file;\r
+ while (!feof(in->file) && (len = fread(buf, 1, BUF_SIZE, in->file)) > 0) {\r
+#endif\r
+ if(len<es){\r
+ int diff=es-len;\r
+ if(j==0) {\r
+ fprintf(pysamerr, "[%s] ERROR: truncated file?: '%s'.\n", __func__, fn[i]);\r
+ return -1;\r
+ }\r
+ fwrite(ebuf, 1, len, fp_file);\r
+ memcpy(ebuf,ebuf+len,diff);\r
+ memcpy(ebuf+diff,buf,len);\r
+ } else {\r
+ if(j!=0) fwrite(ebuf, 1, es, fp_file);\r
+ len-= es;\r
+ memcpy(ebuf,buf+len,es);\r
+ fwrite(buf, 1, len, fp_file);\r
+ }\r
+ j=1;\r
+ }\r
+\r
+ /* check final gzip block */\r
+ {\r
+ const uint8_t gzip1=ebuf[0];\r
+ const uint8_t gzip2=ebuf[1];\r
+ const uint32_t isize=*((uint32_t*)(ebuf+es-4));\r
+ if(((gzip1!=GZIPID1) || (gzip2!=GZIPID2)) || (isize!=0)) {\r
+ fprintf(pysamerr, "[%s] WARNING: Unexpected block structure in file '%s'.", __func__, fn[i]);\r
+ fprintf(pysamerr, " Possible output corruption.\n");\r
+ fwrite(ebuf, 1, es, fp_file);\r
+ }\r
+ }\r
+ bam_header_destroy(old);\r
+ bgzf_close(in);\r
+ }\r
+ free(buf);\r
+ bgzf_close(fp);\r
+ return 0;\r
+}\r
+\r
+\r
+\r
+int main_cat(int argc, char *argv[])\r
+{\r
+ bam_header_t *h = 0;\r
+ char *outfn = 0;\r
+ int c, ret;\r
+ while ((c = getopt(argc, argv, "h:o:")) >= 0) {\r
+ switch (c) {\r
+ case 'h': {\r
+ tamFile fph = sam_open(optarg);\r
+ if (fph == 0) {\r
+ fprintf(pysamerr, "[%s] ERROR: fail to read the header from '%s'.\n", __func__, argv[1]);\r
+ return 1;\r
+ }\r
+ h = sam_header_read(fph);\r
+ sam_close(fph);\r
+ break;\r
+ }\r
+ case 'o': outfn = strdup(optarg); break;\r
+ }\r
+ }\r
+ if (argc - optind < 2) {\r
+ fprintf(pysamerr, "Usage: samtools cat [-h header.sam] [-o out.bam] <in1.bam> <in2.bam> [...]\n");\r
+ return 1;\r
+ }\r
+ ret = bam_cat(argc - optind, argv + optind, h, outfn? outfn : "-");\r
+ free(outfn);\r
+ return ret;\r
+}\r
+++ /dev/null
-#include <ctype.h>
-#include "bam.h"
-
-/*!
- @abstract Get the color encoding the previous and current base
- @param b pointer to an alignment
- @param i The i-th position, 0-based
- @return color
-
- @discussion Returns 0 no color information is found.
- */
-char bam_aux_getCSi(bam1_t *b, int i)
-{
- uint8_t *c = bam_aux_get(b, "CS");
- char *cs = NULL;
-
- // return the base if the tag was not found
- if(0 == c) return 0;
-
- cs = bam_aux2Z(c);
- // adjust for strandedness and leading adaptor
- if(bam1_strand(b)) i = strlen(cs) - 1 - i;
- else i++;
- return cs[i];
-}
-
-/*!
- @abstract Get the color quality of the color encoding the previous and current base
- @param b pointer to an alignment
- @param i The i-th position, 0-based
- @return color quality
-
- @discussion Returns 0 no color information is found.
- */
-char bam_aux_getCQi(bam1_t *b, int i)
-{
- uint8_t *c = bam_aux_get(b, "CQ");
- char *cq = NULL;
-
- // return the base if the tag was not found
- if(0 == c) return 0;
-
- cq = bam_aux2Z(c);
- // adjust for strandedness
- if(bam1_strand(b)) i = strlen(cq) - 1 - i;
- return cq[i];
-}
-
-char bam_aux_nt2int(char a)
-{
- switch(toupper(a)) {
- case 'A':
- return 0;
- break;
- case 'C':
- return 1;
- break;
- case 'G':
- return 2;
- break;
- case 'T':
- return 3;
- break;
- default:
- return 4;
- break;
- }
-}
-
-char bam_aux_ntnt2cs(char a, char b)
-{
- a = bam_aux_nt2int(a);
- b = bam_aux_nt2int(b);
- if(4 == a || 4 == b) return '4';
- return "0123"[(int)(a ^ b)];
-}
-
-/*!
- @abstract Get the color error profile at the give position
- @param b pointer to an alignment
- @return the original color if the color was an error, '-' (dash) otherwise
-
- @discussion Returns 0 no color information is found.
- */
-char bam_aux_getCEi(bam1_t *b, int i)
-{
- int cs_i;
- uint8_t *c = bam_aux_get(b, "CS");
- char *cs = NULL;
- char prev_b, cur_b;
- char cur_color, cor_color;
-
- // return the base if the tag was not found
- if(0 == c) return 0;
-
- cs = bam_aux2Z(c);
-
- // adjust for strandedness and leading adaptor
- if(bam1_strand(b)) { //reverse strand
- cs_i = strlen(cs) - 1 - i;
- // get current color
- cur_color = cs[cs_i];
- // get previous base. Note: must rc adaptor
- prev_b = (cs_i == 1) ? "TGCAN"[(int)bam_aux_nt2int(cs[0])] : bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i+1)];
- // get current base
- cur_b = bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i)];
- }
- else {
- cs_i=i+1;
- // get current color
- cur_color = cs[cs_i];
- // get previous base
- prev_b = (0 == i) ? cs[0] : bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i-1)];
- // get current base
- cur_b = bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i)];
- }
-
- // corrected color
- cor_color = bam_aux_ntnt2cs(prev_b, cur_b);
-
- if(cur_color == cor_color) {
- return '-';
- }
- else {
- return cur_color;
- }
-}
--- /dev/null
+#include "pysam.h"
+
+#include <ctype.h>
+#include "bam.h"
+
+/*!
+ @abstract Get the color encoding the previous and current base
+ @param b pointer to an alignment
+ @param i The i-th position, 0-based
+ @return color
+
+ @discussion Returns 0 no color information is found.
+ */
+char bam_aux_getCSi(bam1_t *b, int i)
+{
+ uint8_t *c = bam_aux_get(b, "CS");
+ char *cs = NULL;
+
+ // return the base if the tag was not found
+ if(0 == c) return 0;
+
+ cs = bam_aux2Z(c);
+ // adjust for strandedness and leading adaptor
+ if(bam1_strand(b)) i = strlen(cs) - 1 - i;
+ else i++;
+ return cs[i];
+}
+
+/*!
+ @abstract Get the color quality of the color encoding the previous and current base
+ @param b pointer to an alignment
+ @param i The i-th position, 0-based
+ @return color quality
+
+ @discussion Returns 0 no color information is found.
+ */
+char bam_aux_getCQi(bam1_t *b, int i)
+{
+ uint8_t *c = bam_aux_get(b, "CQ");
+ char *cq = NULL;
+
+ // return the base if the tag was not found
+ if(0 == c) return 0;
+
+ cq = bam_aux2Z(c);
+ // adjust for strandedness
+ if(bam1_strand(b)) i = strlen(cq) - 1 - i;
+ return cq[i];
+}
+
+char bam_aux_nt2int(char a)
+{
+ switch(toupper(a)) {
+ case 'A':
+ return 0;
+ break;
+ case 'C':
+ return 1;
+ break;
+ case 'G':
+ return 2;
+ break;
+ case 'T':
+ return 3;
+ break;
+ default:
+ return 4;
+ break;
+ }
+}
+
+char bam_aux_ntnt2cs(char a, char b)
+{
+ a = bam_aux_nt2int(a);
+ b = bam_aux_nt2int(b);
+ if(4 == a || 4 == b) return '4';
+ return "0123"[(int)(a ^ b)];
+}
+
+/*!
+ @abstract Get the color error profile at the give position
+ @param b pointer to an alignment
+ @return the original color if the color was an error, '-' (dash) otherwise
+
+ @discussion Returns 0 no color information is found.
+ */
+char bam_aux_getCEi(bam1_t *b, int i)
+{
+ int cs_i;
+ uint8_t *c = bam_aux_get(b, "CS");
+ char *cs = NULL;
+ char prev_b, cur_b;
+ char cur_color, cor_color;
+
+ // return the base if the tag was not found
+ if(0 == c) return 0;
+
+ cs = bam_aux2Z(c);
+
+ // adjust for strandedness and leading adaptor
+ if(bam1_strand(b)) { //reverse strand
+ cs_i = strlen(cs) - 1 - i;
+ // get current color
+ cur_color = cs[cs_i];
+ // get previous base. Note: must rc adaptor
+ prev_b = (cs_i == 1) ? "TGCAN"[(int)bam_aux_nt2int(cs[0])] : bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i+1)];
+ // get current base
+ cur_b = bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i)];
+ }
+ else {
+ cs_i=i+1;
+ // get current color
+ cur_color = cs[cs_i];
+ // get previous base
+ prev_b = (0 == i) ? cs[0] : bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i-1)];
+ // get current base
+ cur_b = bam_nt16_rev_table[bam1_seqi(bam1_seq(b), i)];
+ }
+
+ // corrected color
+ cor_color = bam_aux_ntnt2cs(prev_b, cur_b);
+
+ if(cur_color == cor_color) {
+ return '-';
+ }
+ else {
+ return cur_color;
+ }
+}
+++ /dev/null
-#include <zlib.h>
-#include <stdio.h>
-#include <ctype.h>
-#include <string.h>
-#include <stdlib.h>
-#include <unistd.h>
-#include <assert.h>
-#ifdef _WIN32
-#include <fcntl.h>
-#endif
-#include "kstring.h"
-#include "bam.h"
-#include "sam_header.h"
-#include "kseq.h"
-#include "khash.h"
-
-KSTREAM_INIT(gzFile, gzread, 8192)
-KHASH_MAP_INIT_STR(ref, uint64_t)
-
-void bam_init_header_hash(bam_header_t *header);
-void bam_destroy_header_hash(bam_header_t *header);
-int32_t bam_get_tid(const bam_header_t *header, const char *seq_name);
-
-unsigned char bam_nt16_table[256] = {
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 1, 2, 4, 8, 15,15,15,15, 15,15,15,15, 15, 0 /*=*/,15,15,
- 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15,
- 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15,
- 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15,
- 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
- 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15
-};
-
-unsigned short bam_char2flag_table[256] = {
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,BAM_FREAD1,BAM_FREAD2,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- BAM_FPROPER_PAIR,0,BAM_FMREVERSE,0, 0,BAM_FMUNMAP,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, BAM_FDUP,0,BAM_FQCFAIL,0, 0,0,0,0, 0,0,0,0,
- BAM_FPAIRED,0,BAM_FREVERSE,BAM_FSECONDARY, 0,BAM_FUNMAP,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
- 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0
-};
-
-char *bam_nt16_rev_table = "=ACMGRSVTWYHKDBN";
-
-struct __tamFile_t {
- gzFile fp;
- kstream_t *ks;
- kstring_t *str;
- uint64_t n_lines;
- int is_first;
-};
-
-char **__bam_get_lines(const char *fn, int *_n) // for bam_plcmd.c only
-{
- char **list = 0, *s;
- int n = 0, dret, m = 0;
- gzFile fp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "r") : gzopen(fn, "r");
- kstream_t *ks;
- kstring_t *str;
- str = (kstring_t*)calloc(1, sizeof(kstring_t));
- ks = ks_init(fp);
- while (ks_getuntil(ks, '\n', str, &dret) > 0) {
- if (n == m) {
- m = m? m << 1 : 16;
- list = (char**)realloc(list, m * sizeof(char*));
- }
- if (str->s[str->l-1] == '\r')
- str->s[--str->l] = '\0';
- s = list[n++] = (char*)calloc(str->l + 1, 1);
- strcpy(s, str->s);
- }
- ks_destroy(ks);
- gzclose(fp);
- free(str->s); free(str);
- *_n = n;
- return list;
-}
-
-static bam_header_t *hash2header(const kh_ref_t *hash)
-{
- bam_header_t *header;
- khiter_t k;
- header = bam_header_init();
- header->n_targets = kh_size(hash);
- header->target_name = (char**)calloc(kh_size(hash), sizeof(char*));
- header->target_len = (uint32_t*)calloc(kh_size(hash), 4);
- for (k = kh_begin(hash); k != kh_end(hash); ++k) {
- if (kh_exist(hash, k)) {
- int i = (int)kh_value(hash, k);
- header->target_name[i] = (char*)kh_key(hash, k);
- header->target_len[i] = kh_value(hash, k)>>32;
- }
- }
- bam_init_header_hash(header);
- return header;
-}
-bam_header_t *sam_header_read2(const char *fn)
-{
- bam_header_t *header;
- int c, dret, ret, error = 0;
- gzFile fp;
- kstream_t *ks;
- kstring_t *str;
- kh_ref_t *hash;
- khiter_t k;
- if (fn == 0) return 0;
- fp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "r") : gzopen(fn, "r");
- if (fp == 0) return 0;
- hash = kh_init(ref);
- ks = ks_init(fp);
- str = (kstring_t*)calloc(1, sizeof(kstring_t));
- while (ks_getuntil(ks, 0, str, &dret) > 0) {
- char *s = strdup(str->s);
- int len, i;
- i = kh_size(hash);
- ks_getuntil(ks, 0, str, &dret);
- len = atoi(str->s);
- k = kh_put(ref, hash, s, &ret);
- if (ret == 0) {
- fprintf(stderr, "[sam_header_read2] duplicated sequence name: %s\n", s);
- error = 1;
- }
- kh_value(hash, k) = (uint64_t)len<<32 | i;
- if (dret != '\n')
- while ((c = ks_getc(ks)) != '\n' && c != -1);
- }
- ks_destroy(ks);
- gzclose(fp);
- free(str->s); free(str);
- fprintf(stderr, "[sam_header_read2] %d sequences loaded.\n", kh_size(hash));
- if (error) return 0;
- header = hash2header(hash);
- kh_destroy(ref, hash);
- return header;
-}
-static inline uint8_t *alloc_data(bam1_t *b, int size)
-{
- if (b->m_data < size) {
- b->m_data = size;
- kroundup32(b->m_data);
- b->data = (uint8_t*)realloc(b->data, b->m_data);
- }
- return b->data;
-}
-static inline void parse_error(int64_t n_lines, const char * __restrict msg)
-{
- fprintf(stderr, "Parse error at line %lld: %s\n", (long long)n_lines, msg);
- abort();
-}
-static inline void append_text(bam_header_t *header, kstring_t *str)
-{
- size_t x = header->l_text, y = header->l_text + str->l + 2; // 2 = 1 byte dret + 1 byte null
- kroundup32(x); kroundup32(y);
- if (x < y)
- {
- header->n_text = y;
- header->text = (char*)realloc(header->text, y);
- if ( !header->text )
- {
- fprintf(stderr,"realloc failed to alloc %ld bytes\n", y);
- abort();
- }
- }
- // Sanity check
- if ( header->l_text+str->l+1 >= header->n_text )
- {
- fprintf(stderr,"append_text FIXME: %ld>=%ld, x=%ld,y=%ld\n", header->l_text+str->l+1,header->n_text,x,y);
- abort();
- }
- strncpy(header->text + header->l_text, str->s, str->l+1); // we cannot use strcpy() here.
- header->l_text += str->l + 1;
- header->text[header->l_text] = 0;
-}
-
-int sam_header_parse(bam_header_t *h)
-{
- char **tmp;
- int i;
- free(h->target_len); free(h->target_name);
- h->n_targets = 0; h->target_len = 0; h->target_name = 0;
- if (h->l_text < 3) return 0;
- if (h->dict == 0) h->dict = sam_header_parse2(h->text);
- tmp = sam_header2list(h->dict, "SQ", "SN", &h->n_targets);
- if (h->n_targets == 0) return 0;
- h->target_name = calloc(h->n_targets, sizeof(void*));
- for (i = 0; i < h->n_targets; ++i)
- h->target_name[i] = strdup(tmp[i]);
- free(tmp);
- tmp = sam_header2list(h->dict, "SQ", "LN", &h->n_targets);
- h->target_len = calloc(h->n_targets, 4);
- for (i = 0; i < h->n_targets; ++i)
- h->target_len[i] = atoi(tmp[i]);
- free(tmp);
- return h->n_targets;
-}
-
-bam_header_t *sam_header_read(tamFile fp)
-{
- int ret, dret;
- bam_header_t *header = bam_header_init();
- kstring_t *str = fp->str;
- while ((ret = ks_getuntil(fp->ks, KS_SEP_TAB, str, &dret)) >= 0 && str->s[0] == '@') { // skip header
- str->s[str->l] = dret; // note that str->s is NOT null terminated!!
- append_text(header, str);
- if (dret != '\n') {
- ret = ks_getuntil(fp->ks, '\n', str, &dret);
- str->s[str->l] = '\n'; // NOT null terminated!!
- append_text(header, str);
- }
- ++fp->n_lines;
- }
- sam_header_parse(header);
- bam_init_header_hash(header);
- fp->is_first = 1;
- return header;
-}
-
-int sam_read1(tamFile fp, bam_header_t *header, bam1_t *b)
-{
- int ret, doff, doff0, dret, z = 0;
- bam1_core_t *c = &b->core;
- kstring_t *str = fp->str;
- kstream_t *ks = fp->ks;
-
- if (fp->is_first) {
- fp->is_first = 0;
- ret = str->l;
- } else {
- do { // special consideration for empty lines
- ret = ks_getuntil(fp->ks, KS_SEP_TAB, str, &dret);
- if (ret >= 0) z += str->l + 1;
- } while (ret == 0);
- }
- if (ret < 0) return -1;
- ++fp->n_lines;
- doff = 0;
-
- { // name
- c->l_qname = strlen(str->s) + 1;
- memcpy(alloc_data(b, doff + c->l_qname) + doff, str->s, c->l_qname);
- doff += c->l_qname;
- }
- { // flag
- long flag;
- char *s;
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
- flag = strtol((char*)str->s, &s, 0);
- if (*s) { // not the end of the string
- flag = 0;
- for (s = str->s; *s; ++s)
- flag |= bam_char2flag_table[(int)*s];
- }
- c->flag = flag;
- }
- { // tid, pos, qual
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->tid = bam_get_tid(header, str->s);
- if (c->tid < 0 && strcmp(str->s, "*")) {
- if (header->n_targets == 0) {
- fprintf(stderr, "[sam_read1] missing header? Abort!\n");
- exit(1);
- } else fprintf(stderr, "[sam_read1] reference '%s' is recognized as '*'.\n", str->s);
- }
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->pos = isdigit(str->s[0])? atoi(str->s) - 1 : -1;
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->qual = isdigit(str->s[0])? atoi(str->s) : 0;
- if (ret < 0) return -2;
- }
- { // cigar
- char *s, *t;
- int i, op;
- long x;
- c->n_cigar = 0;
- if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -3;
- z += str->l + 1;
- if (str->s[0] != '*') {
- for (s = str->s; *s; ++s) {
- if (isalpha(*s)) ++c->n_cigar;
- else if (!isdigit(*s)) parse_error(fp->n_lines, "invalid CIGAR character");
- }
- b->data = alloc_data(b, doff + c->n_cigar * 4);
- for (i = 0, s = str->s; i != c->n_cigar; ++i) {
- x = strtol(s, &t, 10);
- op = toupper(*t);
- if (op == 'M' || op == '=' || op == 'X') op = BAM_CMATCH;
- else if (op == 'I') op = BAM_CINS;
- else if (op == 'D') op = BAM_CDEL;
- else if (op == 'N') op = BAM_CREF_SKIP;
- else if (op == 'S') op = BAM_CSOFT_CLIP;
- else if (op == 'H') op = BAM_CHARD_CLIP;
- else if (op == 'P') op = BAM_CPAD;
- else parse_error(fp->n_lines, "invalid CIGAR operation");
- s = t + 1;
- bam1_cigar(b)[i] = x << BAM_CIGAR_SHIFT | op;
- }
- if (*s) parse_error(fp->n_lines, "unmatched CIGAR operation");
- c->bin = bam_reg2bin(c->pos, bam_calend(c, bam1_cigar(b)));
- doff += c->n_cigar * 4;
- } else {
- if (!(c->flag&BAM_FUNMAP)) {
- fprintf(stderr, "Parse warning at line %lld: mapped sequence without CIGAR\n", (long long)fp->n_lines);
- c->flag |= BAM_FUNMAP;
- }
- c->bin = bam_reg2bin(c->pos, c->pos + 1);
- }
- }
- { // mtid, mpos, isize
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
- c->mtid = strcmp(str->s, "=")? bam_get_tid(header, str->s) : c->tid;
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
- c->mpos = isdigit(str->s[0])? atoi(str->s) - 1 : -1;
- ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
- c->isize = (str->s[0] == '-' || isdigit(str->s[0]))? atoi(str->s) : 0;
- if (ret < 0) return -4;
- }
- { // seq and qual
- int i;
- uint8_t *p = 0;
- if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -5; // seq
- z += str->l + 1;
- if (strcmp(str->s, "*")) {
- c->l_qseq = strlen(str->s);
- if (c->n_cigar && c->l_qseq != (int32_t)bam_cigar2qlen(c, bam1_cigar(b)))
- parse_error(fp->n_lines, "CIGAR and sequence length are inconsistent");
- p = (uint8_t*)alloc_data(b, doff + c->l_qseq + (c->l_qseq+1)/2) + doff;
- memset(p, 0, (c->l_qseq+1)/2);
- for (i = 0; i < c->l_qseq; ++i)
- p[i/2] |= bam_nt16_table[(int)str->s[i]] << 4*(1-i%2);
- } else c->l_qseq = 0;
- if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -6; // qual
- z += str->l + 1;
- if (strcmp(str->s, "*") && c->l_qseq != strlen(str->s))
- parse_error(fp->n_lines, "sequence and quality are inconsistent");
- p += (c->l_qseq+1)/2;
- if (strcmp(str->s, "*") == 0) for (i = 0; i < c->l_qseq; ++i) p[i] = 0xff;
- else for (i = 0; i < c->l_qseq; ++i) p[i] = str->s[i] - 33;
- doff += c->l_qseq + (c->l_qseq+1)/2;
- }
- doff0 = doff;
- if (dret != '\n' && dret != '\r') { // aux
- while (ks_getuntil(ks, KS_SEP_TAB, str, &dret) >= 0) {
- uint8_t *s, type, key[2];
- z += str->l + 1;
- if (str->l < 6 || str->s[2] != ':' || str->s[4] != ':')
- parse_error(fp->n_lines, "missing colon in auxiliary data");
- key[0] = str->s[0]; key[1] = str->s[1];
- type = str->s[3];
- s = alloc_data(b, doff + 3) + doff;
- s[0] = key[0]; s[1] = key[1]; s += 2; doff += 2;
- if (type == 'A' || type == 'a' || type == 'c' || type == 'C') { // c and C for backward compatibility
- s = alloc_data(b, doff + 2) + doff;
- *s++ = 'A'; *s = str->s[5];
- doff += 2;
- } else if (type == 'I' || type == 'i') {
- long long x;
- s = alloc_data(b, doff + 5) + doff;
- x = (long long)atoll(str->s + 5);
- if (x < 0) {
- if (x >= -127) {
- *s++ = 'c'; *(int8_t*)s = (int8_t)x;
- s += 1; doff += 2;
- } else if (x >= -32767) {
- *s++ = 's'; *(int16_t*)s = (int16_t)x;
- s += 2; doff += 3;
- } else {
- *s++ = 'i'; *(int32_t*)s = (int32_t)x;
- s += 4; doff += 5;
- if (x < -2147483648ll)
- fprintf(stderr, "Parse warning at line %lld: integer %lld is out of range.",
- (long long)fp->n_lines, x);
- }
- } else {
- if (x <= 255) {
- *s++ = 'C'; *s++ = (uint8_t)x;
- doff += 2;
- } else if (x <= 65535) {
- *s++ = 'S'; *(uint16_t*)s = (uint16_t)x;
- s += 2; doff += 3;
- } else {
- *s++ = 'I'; *(uint32_t*)s = (uint32_t)x;
- s += 4; doff += 5;
- if (x > 4294967295ll)
- fprintf(stderr, "Parse warning at line %lld: integer %lld is out of range.",
- (long long)fp->n_lines, x);
- }
- }
- } else if (type == 'f') {
- s = alloc_data(b, doff + 5) + doff;
- *s++ = 'f';
- *(float*)s = (float)atof(str->s + 5);
- s += 4; doff += 5;
- } else if (type == 'd') {
- s = alloc_data(b, doff + 9) + doff;
- *s++ = 'd';
- *(float*)s = (float)atof(str->s + 9);
- s += 8; doff += 9;
- } else if (type == 'Z' || type == 'H') {
- int size = 1 + (str->l - 5) + 1;
- if (type == 'H') { // check whether the hex string is valid
- int i;
- if ((str->l - 5) % 2 == 1) parse_error(fp->n_lines, "length of the hex string not even");
- for (i = 0; i < str->l - 5; ++i) {
- int c = toupper(str->s[5 + i]);
- if (!((c >= '0' && c <= '9') || (c >= 'A' && c <= 'F')))
- parse_error(fp->n_lines, "invalid hex character");
- }
- }
- s = alloc_data(b, doff + size) + doff;
- *s++ = type;
- memcpy(s, str->s + 5, str->l - 5);
- s[str->l - 5] = 0;
- doff += size;
- } else parse_error(fp->n_lines, "unrecognized type");
- if (dret == '\n' || dret == '\r') break;
- }
- }
- b->l_aux = doff - doff0;
- b->data_len = doff;
- return z;
-}
-
-tamFile sam_open(const char *fn)
-{
- tamFile fp;
- gzFile gzfp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "rb") : gzopen(fn, "rb");
- if (gzfp == 0) return 0;
- fp = (tamFile)calloc(1, sizeof(struct __tamFile_t));
- fp->str = (kstring_t*)calloc(1, sizeof(kstring_t));
- fp->fp = gzfp;
- fp->ks = ks_init(fp->fp);
- return fp;
-}
-
-void sam_close(tamFile fp)
-{
- if (fp) {
- ks_destroy(fp->ks);
- gzclose(fp->fp);
- free(fp->str->s); free(fp->str);
- free(fp);
- }
-}
--- /dev/null
+#include "pysam.h"
+
+#include <zlib.h>
+#include <stdio.h>
+#include <ctype.h>
+#include <string.h>
+#include <stdlib.h>
+#include <unistd.h>
+#include <assert.h>
+#ifdef _WIN32
+#include <fcntl.h>
+#endif
+#include "kstring.h"
+#include "bam.h"
+#include "sam_header.h"
+#include "kseq.h"
+#include "khash.h"
+
+KSTREAM_INIT(gzFile, gzread, 8192)
+KHASH_MAP_INIT_STR(ref, uint64_t)
+
+void bam_init_header_hash(bam_header_t *header);
+void bam_destroy_header_hash(bam_header_t *header);
+int32_t bam_get_tid(const bam_header_t *header, const char *seq_name);
+
+unsigned char bam_nt16_table[256] = {
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 1, 2, 4, 8, 15,15,15,15, 15,15,15,15, 15, 0 /*=*/,15,15,
+ 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15,
+ 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15,
+ 15, 1,14, 2, 13,15,15, 4, 11,15,15,12, 15, 3,15,15,
+ 15,15, 5, 6, 8,15, 7, 9, 15,10,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15,
+ 15,15,15,15, 15,15,15,15, 15,15,15,15, 15,15,15,15
+};
+
+unsigned short bam_char2flag_table[256] = {
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,BAM_FREAD1,BAM_FREAD2,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ BAM_FPROPER_PAIR,0,BAM_FMREVERSE,0, 0,BAM_FMUNMAP,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, BAM_FDUP,0,BAM_FQCFAIL,0, 0,0,0,0, 0,0,0,0,
+ BAM_FPAIRED,0,BAM_FREVERSE,BAM_FSECONDARY, 0,BAM_FUNMAP,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0,
+ 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0
+};
+
+char *bam_nt16_rev_table = "=ACMGRSVTWYHKDBN";
+
+struct __tamFile_t {
+ gzFile fp;
+ kstream_t *ks;
+ kstring_t *str;
+ uint64_t n_lines;
+ int is_first;
+};
+
+char **__bam_get_lines(const char *fn, int *_n) // for bam_plcmd.c only
+{
+ char **list = 0, *s;
+ int n = 0, dret, m = 0;
+ gzFile fp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "r") : gzopen(fn, "r");
+ kstream_t *ks;
+ kstring_t *str;
+ str = (kstring_t*)calloc(1, sizeof(kstring_t));
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, '\n', str, &dret) > 0) {
+ if (n == m) {
+ m = m? m << 1 : 16;
+ list = (char**)realloc(list, m * sizeof(char*));
+ }
+ if (str->s[str->l-1] == '\r')
+ str->s[--str->l] = '\0';
+ s = list[n++] = (char*)calloc(str->l + 1, 1);
+ strcpy(s, str->s);
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(str->s); free(str);
+ *_n = n;
+ return list;
+}
+
+static bam_header_t *hash2header(const kh_ref_t *hash)
+{
+ bam_header_t *header;
+ khiter_t k;
+ header = bam_header_init();
+ header->n_targets = kh_size(hash);
+ header->target_name = (char**)calloc(kh_size(hash), sizeof(char*));
+ header->target_len = (uint32_t*)calloc(kh_size(hash), 4);
+ for (k = kh_begin(hash); k != kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ int i = (int)kh_value(hash, k);
+ header->target_name[i] = (char*)kh_key(hash, k);
+ header->target_len[i] = kh_value(hash, k)>>32;
+ }
+ }
+ bam_init_header_hash(header);
+ return header;
+}
+bam_header_t *sam_header_read2(const char *fn)
+{
+ bam_header_t *header;
+ int c, dret, ret, error = 0;
+ gzFile fp;
+ kstream_t *ks;
+ kstring_t *str;
+ kh_ref_t *hash;
+ khiter_t k;
+ if (fn == 0) return 0;
+ fp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "r") : gzopen(fn, "r");
+ if (fp == 0) return 0;
+ hash = kh_init(ref);
+ ks = ks_init(fp);
+ str = (kstring_t*)calloc(1, sizeof(kstring_t));
+ while (ks_getuntil(ks, 0, str, &dret) > 0) {
+ char *s = strdup(str->s);
+ int len, i;
+ i = kh_size(hash);
+ ks_getuntil(ks, 0, str, &dret);
+ len = atoi(str->s);
+ k = kh_put(ref, hash, s, &ret);
+ if (ret == 0) {
+ fprintf(pysamerr, "[sam_header_read2] duplicated sequence name: %s\n", s);
+ error = 1;
+ }
+ kh_value(hash, k) = (uint64_t)len<<32 | i;
+ if (dret != '\n')
+ while ((c = ks_getc(ks)) != '\n' && c != -1);
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(str->s); free(str);
+ fprintf(pysamerr, "[sam_header_read2] %d sequences loaded.\n", kh_size(hash));
+ if (error) return 0;
+ header = hash2header(hash);
+ kh_destroy(ref, hash);
+ return header;
+}
+static inline uint8_t *alloc_data(bam1_t *b, int size)
+{
+ if (b->m_data < size) {
+ b->m_data = size;
+ kroundup32(b->m_data);
+ b->data = (uint8_t*)realloc(b->data, b->m_data);
+ }
+ return b->data;
+}
+static inline void parse_error(int64_t n_lines, const char * __restrict msg)
+{
+ fprintf(pysamerr, "Parse error at line %lld: %s\n", (long long)n_lines, msg);
+ abort();
+}
+static inline void append_text(bam_header_t *header, kstring_t *str)
+{
+ size_t x = header->l_text, y = header->l_text + str->l + 2; // 2 = 1 byte dret + 1 byte null
+ kroundup32(x); kroundup32(y);
+ if (x < y)
+ {
+ header->n_text = y;
+ header->text = (char*)realloc(header->text, y);
+ if ( !header->text )
+ {
+ fprintf(pysamerr,"realloc failed to alloc %ld bytes\n", y);
+ abort();
+ }
+ }
+ // Sanity check
+ if ( header->l_text+str->l+1 >= header->n_text )
+ {
+ fprintf(pysamerr,"append_text FIXME: %ld>=%ld, x=%ld,y=%ld\n", header->l_text+str->l+1,header->n_text,x,y);
+ abort();
+ }
+ strncpy(header->text + header->l_text, str->s, str->l+1); // we cannot use strcpy() here.
+ header->l_text += str->l + 1;
+ header->text[header->l_text] = 0;
+}
+
+int sam_header_parse(bam_header_t *h)
+{
+ char **tmp;
+ int i;
+ free(h->target_len); free(h->target_name);
+ h->n_targets = 0; h->target_len = 0; h->target_name = 0;
+ if (h->l_text < 3) return 0;
+ if (h->dict == 0) h->dict = sam_header_parse2(h->text);
+ tmp = sam_header2list(h->dict, "SQ", "SN", &h->n_targets);
+ if (h->n_targets == 0) return 0;
+ h->target_name = calloc(h->n_targets, sizeof(void*));
+ for (i = 0; i < h->n_targets; ++i)
+ h->target_name[i] = strdup(tmp[i]);
+ free(tmp);
+ tmp = sam_header2list(h->dict, "SQ", "LN", &h->n_targets);
+ h->target_len = calloc(h->n_targets, 4);
+ for (i = 0; i < h->n_targets; ++i)
+ h->target_len[i] = atoi(tmp[i]);
+ free(tmp);
+ return h->n_targets;
+}
+
+bam_header_t *sam_header_read(tamFile fp)
+{
+ int ret, dret;
+ bam_header_t *header = bam_header_init();
+ kstring_t *str = fp->str;
+ while ((ret = ks_getuntil(fp->ks, KS_SEP_TAB, str, &dret)) >= 0 && str->s[0] == '@') { // skip header
+ str->s[str->l] = dret; // note that str->s is NOT null terminated!!
+ append_text(header, str);
+ if (dret != '\n') {
+ ret = ks_getuntil(fp->ks, '\n', str, &dret);
+ str->s[str->l] = '\n'; // NOT null terminated!!
+ append_text(header, str);
+ }
+ ++fp->n_lines;
+ }
+ sam_header_parse(header);
+ bam_init_header_hash(header);
+ fp->is_first = 1;
+ return header;
+}
+
+int sam_read1(tamFile fp, bam_header_t *header, bam1_t *b)
+{
+ int ret, doff, doff0, dret, z = 0;
+ bam1_core_t *c = &b->core;
+ kstring_t *str = fp->str;
+ kstream_t *ks = fp->ks;
+
+ if (fp->is_first) {
+ fp->is_first = 0;
+ ret = str->l;
+ } else {
+ do { // special consideration for empty lines
+ ret = ks_getuntil(fp->ks, KS_SEP_TAB, str, &dret);
+ if (ret >= 0) z += str->l + 1;
+ } while (ret == 0);
+ }
+ if (ret < 0) return -1;
+ ++fp->n_lines;
+ doff = 0;
+
+ { // name
+ c->l_qname = strlen(str->s) + 1;
+ memcpy(alloc_data(b, doff + c->l_qname) + doff, str->s, c->l_qname);
+ doff += c->l_qname;
+ }
+ { // flag
+ long flag;
+ char *s;
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
+ flag = strtol((char*)str->s, &s, 0);
+ if (*s) { // not the end of the string
+ flag = 0;
+ for (s = str->s; *s; ++s)
+ flag |= bam_char2flag_table[(int)*s];
+ }
+ c->flag = flag;
+ }
+ { // tid, pos, qual
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->tid = bam_get_tid(header, str->s);
+ if (c->tid < 0 && strcmp(str->s, "*")) {
+ if (header->n_targets == 0) {
+ fprintf(pysamerr, "[sam_read1] missing header? Abort!\n");
+ exit(1);
+ } else fprintf(pysamerr, "[sam_read1] reference '%s' is recognized as '*'.\n", str->s);
+ }
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->pos = isdigit(str->s[0])? atoi(str->s) - 1 : -1;
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1; c->qual = isdigit(str->s[0])? atoi(str->s) : 0;
+ if (ret < 0) return -2;
+ }
+ { // cigar
+ char *s, *t;
+ int i, op;
+ long x;
+ c->n_cigar = 0;
+ if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -3;
+ z += str->l + 1;
+ if (str->s[0] != '*') {
+ for (s = str->s; *s; ++s) {
+ if (isalpha(*s)) ++c->n_cigar;
+ else if (!isdigit(*s)) parse_error(fp->n_lines, "invalid CIGAR character");
+ }
+ b->data = alloc_data(b, doff + c->n_cigar * 4);
+ for (i = 0, s = str->s; i != c->n_cigar; ++i) {
+ x = strtol(s, &t, 10);
+ op = toupper(*t);
+ if (op == 'M' || op == '=' || op == 'X') op = BAM_CMATCH;
+ else if (op == 'I') op = BAM_CINS;
+ else if (op == 'D') op = BAM_CDEL;
+ else if (op == 'N') op = BAM_CREF_SKIP;
+ else if (op == 'S') op = BAM_CSOFT_CLIP;
+ else if (op == 'H') op = BAM_CHARD_CLIP;
+ else if (op == 'P') op = BAM_CPAD;
+ else parse_error(fp->n_lines, "invalid CIGAR operation");
+ s = t + 1;
+ bam1_cigar(b)[i] = x << BAM_CIGAR_SHIFT | op;
+ }
+ if (*s) parse_error(fp->n_lines, "unmatched CIGAR operation");
+ c->bin = bam_reg2bin(c->pos, bam_calend(c, bam1_cigar(b)));
+ doff += c->n_cigar * 4;
+ } else {
+ if (!(c->flag&BAM_FUNMAP)) {
+ fprintf(pysamerr, "Parse warning at line %lld: mapped sequence without CIGAR\n", (long long)fp->n_lines);
+ c->flag |= BAM_FUNMAP;
+ }
+ c->bin = bam_reg2bin(c->pos, c->pos + 1);
+ }
+ }
+ { // mtid, mpos, isize
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
+ c->mtid = strcmp(str->s, "=")? bam_get_tid(header, str->s) : c->tid;
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
+ c->mpos = isdigit(str->s[0])? atoi(str->s) - 1 : -1;
+ ret = ks_getuntil(ks, KS_SEP_TAB, str, &dret); z += str->l + 1;
+ c->isize = (str->s[0] == '-' || isdigit(str->s[0]))? atoi(str->s) : 0;
+ if (ret < 0) return -4;
+ }
+ { // seq and qual
+ int i;
+ uint8_t *p = 0;
+ if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -5; // seq
+ z += str->l + 1;
+ if (strcmp(str->s, "*")) {
+ c->l_qseq = strlen(str->s);
+ if (c->n_cigar && c->l_qseq != (int32_t)bam_cigar2qlen(c, bam1_cigar(b)))
+ parse_error(fp->n_lines, "CIGAR and sequence length are inconsistent");
+ p = (uint8_t*)alloc_data(b, doff + c->l_qseq + (c->l_qseq+1)/2) + doff;
+ memset(p, 0, (c->l_qseq+1)/2);
+ for (i = 0; i < c->l_qseq; ++i)
+ p[i/2] |= bam_nt16_table[(int)str->s[i]] << 4*(1-i%2);
+ } else c->l_qseq = 0;
+ if (ks_getuntil(ks, KS_SEP_TAB, str, &dret) < 0) return -6; // qual
+ z += str->l + 1;
+ if (strcmp(str->s, "*") && c->l_qseq != strlen(str->s))
+ parse_error(fp->n_lines, "sequence and quality are inconsistent");
+ p += (c->l_qseq+1)/2;
+ if (strcmp(str->s, "*") == 0) for (i = 0; i < c->l_qseq; ++i) p[i] = 0xff;
+ else for (i = 0; i < c->l_qseq; ++i) p[i] = str->s[i] - 33;
+ doff += c->l_qseq + (c->l_qseq+1)/2;
+ }
+ doff0 = doff;
+ if (dret != '\n' && dret != '\r') { // aux
+ while (ks_getuntil(ks, KS_SEP_TAB, str, &dret) >= 0) {
+ uint8_t *s, type, key[2];
+ z += str->l + 1;
+ if (str->l < 6 || str->s[2] != ':' || str->s[4] != ':')
+ parse_error(fp->n_lines, "missing colon in auxiliary data");
+ key[0] = str->s[0]; key[1] = str->s[1];
+ type = str->s[3];
+ s = alloc_data(b, doff + 3) + doff;
+ s[0] = key[0]; s[1] = key[1]; s += 2; doff += 2;
+ if (type == 'A' || type == 'a' || type == 'c' || type == 'C') { // c and C for backward compatibility
+ s = alloc_data(b, doff + 2) + doff;
+ *s++ = 'A'; *s = str->s[5];
+ doff += 2;
+ } else if (type == 'I' || type == 'i') {
+ long long x;
+ s = alloc_data(b, doff + 5) + doff;
+ x = (long long)atoll(str->s + 5);
+ if (x < 0) {
+ if (x >= -127) {
+ *s++ = 'c'; *(int8_t*)s = (int8_t)x;
+ s += 1; doff += 2;
+ } else if (x >= -32767) {
+ *s++ = 's'; *(int16_t*)s = (int16_t)x;
+ s += 2; doff += 3;
+ } else {
+ *s++ = 'i'; *(int32_t*)s = (int32_t)x;
+ s += 4; doff += 5;
+ if (x < -2147483648ll)
+ fprintf(pysamerr, "Parse warning at line %lld: integer %lld is out of range.",
+ (long long)fp->n_lines, x);
+ }
+ } else {
+ if (x <= 255) {
+ *s++ = 'C'; *s++ = (uint8_t)x;
+ doff += 2;
+ } else if (x <= 65535) {
+ *s++ = 'S'; *(uint16_t*)s = (uint16_t)x;
+ s += 2; doff += 3;
+ } else {
+ *s++ = 'I'; *(uint32_t*)s = (uint32_t)x;
+ s += 4; doff += 5;
+ if (x > 4294967295ll)
+ fprintf(pysamerr, "Parse warning at line %lld: integer %lld is out of range.",
+ (long long)fp->n_lines, x);
+ }
+ }
+ } else if (type == 'f') {
+ s = alloc_data(b, doff + 5) + doff;
+ *s++ = 'f';
+ *(float*)s = (float)atof(str->s + 5);
+ s += 4; doff += 5;
+ } else if (type == 'd') {
+ s = alloc_data(b, doff + 9) + doff;
+ *s++ = 'd';
+ *(float*)s = (float)atof(str->s + 9);
+ s += 8; doff += 9;
+ } else if (type == 'Z' || type == 'H') {
+ int size = 1 + (str->l - 5) + 1;
+ if (type == 'H') { // check whether the hex string is valid
+ int i;
+ if ((str->l - 5) % 2 == 1) parse_error(fp->n_lines, "length of the hex string not even");
+ for (i = 0; i < str->l - 5; ++i) {
+ int c = toupper(str->s[5 + i]);
+ if (!((c >= '0' && c <= '9') || (c >= 'A' && c <= 'F')))
+ parse_error(fp->n_lines, "invalid hex character");
+ }
+ }
+ s = alloc_data(b, doff + size) + doff;
+ *s++ = type;
+ memcpy(s, str->s + 5, str->l - 5);
+ s[str->l - 5] = 0;
+ doff += size;
+ } else if (type == 'B') {
+ int32_t n = 0, Bsize, k = 0, size;
+ char *p;
+ if (str->l < 8) parse_error(fp->n_lines, "too few values in aux type B");
+ Bsize = bam_aux_type2size(str->s[5]); // the size of each element
+ for (p = (char*)str->s + 6; *p; ++p) // count the number of elements in the array
+ if (*p == ',') ++n;
+ p = str->s + 7; // now p points to the first number in the array
+ size = 6 + Bsize * n; // total number of bytes allocated to this tag
+ s = alloc_data(b, doff + 6 * Bsize * n) + doff; // allocate memory
+ *s++ = 'B'; *s++ = str->s[5];
+ memcpy(s, &n, 4); s += 4; // write the number of elements
+ if (str->s[5] == 'c') while (p < str->s + str->l) ((int8_t*)s)[k++] = (int8_t)strtol(p, &p, 0), ++p;
+ else if (str->s[5] == 'C') while (p < str->s + str->l) ((uint8_t*)s)[k++] = (uint8_t)strtol(p, &p, 0), ++p;
+ else if (str->s[5] == 's') while (p < str->s + str->l) ((int16_t*)s)[k++] = (int16_t)strtol(p, &p, 0), ++p; // FIXME: avoid unaligned memory
+ else if (str->s[5] == 'S') while (p < str->s + str->l) ((uint16_t*)s)[k++] = (uint16_t)strtol(p, &p, 0), ++p;
+ else if (str->s[5] == 'i') while (p < str->s + str->l) ((int32_t*)s)[k++] = (int32_t)strtol(p, &p, 0), ++p;
+ else if (str->s[5] == 'I') while (p < str->s + str->l) ((uint32_t*)s)[k++] = (uint32_t)strtol(p, &p, 0), ++p;
+ else if (str->s[5] == 'f') while (p < str->s + str->l) ((float*)s)[k++] = (float)strtof(p, &p), ++p;
+ else parse_error(fp->n_lines, "unrecognized array type");
+ s += Bsize * n; doff += size;
+ } else parse_error(fp->n_lines, "unrecognized type");
+ if (dret == '\n' || dret == '\r') break;
+ }
+ }
+ b->l_aux = doff - doff0;
+ b->data_len = doff;
+ return z;
+}
+
+tamFile sam_open(const char *fn)
+{
+ tamFile fp;
+ gzFile gzfp = (strcmp(fn, "-") == 0)? gzdopen(fileno(stdin), "rb") : gzopen(fn, "rb");
+ if (gzfp == 0) return 0;
+ fp = (tamFile)calloc(1, sizeof(struct __tamFile_t));
+ fp->str = (kstring_t*)calloc(1, sizeof(kstring_t));
+ fp->fp = gzfp;
+ fp->ks = ks_init(fp->fp);
+ return fp;
+}
+
+void sam_close(tamFile fp)
+{
+ if (fp) {
+ ks_destroy(fp->ks);
+ gzclose(fp->fp);
+ free(fp->str->s); free(fp->str);
+ free(fp);
+ }
+}
+++ /dev/null
-#include <ctype.h>
-#include <assert.h>
-#include "bam.h"
-#include "khash.h"
-#include "ksort.h"
-#include "bam_endian.h"
-#ifdef _USE_KNETFILE
-#include "knetfile.h"
-#endif
-
-/*!
- @header
-
- Alignment indexing. Before indexing, BAM must be sorted based on the
- leftmost coordinate of alignments. In indexing, BAM uses two indices:
- a UCSC binning index and a simple linear index. The binning index is
- efficient for alignments spanning long distance, while the auxiliary
- linear index helps to reduce unnecessary seek calls especially for
- short alignments.
-
- The UCSC binning scheme was suggested by Richard Durbin and Lincoln
- Stein and is explained by Kent et al. (2002). In this scheme, each bin
- represents a contiguous genomic region which can be fully contained in
- another bin; each alignment is associated with a bin which represents
- the smallest region containing the entire alignment. The binning
- scheme is essentially another representation of R-tree. A distinct bin
- uniquely corresponds to a distinct internal node in a R-tree. Bin A is
- a child of Bin B if region A is contained in B.
-
- In BAM, each bin may span 2^29, 2^26, 2^23, 2^20, 2^17 or 2^14 bp. Bin
- 0 spans a 512Mbp region, bins 1-8 span 64Mbp, 9-72 8Mbp, 73-584 1Mbp,
- 585-4680 128Kbp and bins 4681-37449 span 16Kbp regions. If we want to
- find the alignments overlapped with a region [rbeg,rend), we need to
- calculate the list of bins that may be overlapped the region and test
- the alignments in the bins to confirm the overlaps. If the specified
- region is short, typically only a few alignments in six bins need to
- be retrieved. The overlapping alignments can be quickly fetched.
-
- */
-
-#define BAM_MIN_CHUNK_GAP 32768
-// 1<<14 is the size of minimum bin.
-#define BAM_LIDX_SHIFT 14
-
-#define BAM_MAX_BIN 37450 // =(8^6-1)/7+1
-
-typedef struct {
- uint64_t u, v;
-} pair64_t;
-
-#define pair64_lt(a,b) ((a).u < (b).u)
-KSORT_INIT(off, pair64_t, pair64_lt)
-
-typedef struct {
- uint32_t m, n;
- pair64_t *list;
-} bam_binlist_t;
-
-typedef struct {
- int32_t n, m;
- uint64_t *offset;
-} bam_lidx_t;
-
-KHASH_MAP_INIT_INT(i, bam_binlist_t)
-
-struct __bam_index_t {
- int32_t n;
- uint64_t n_no_coor; // unmapped reads without coordinate
- khash_t(i) **index;
- bam_lidx_t *index2;
-};
-
-// requirement: len <= LEN_MASK
-static inline void insert_offset(khash_t(i) *h, int bin, uint64_t beg, uint64_t end)
-{
- khint_t k;
- bam_binlist_t *l;
- int ret;
- k = kh_put(i, h, bin, &ret);
- l = &kh_value(h, k);
- if (ret) { // not present
- l->m = 1; l->n = 0;
- l->list = (pair64_t*)calloc(l->m, 16);
- }
- if (l->n == l->m) {
- l->m <<= 1;
- l->list = (pair64_t*)realloc(l->list, l->m * 16);
- }
- l->list[l->n].u = beg; l->list[l->n++].v = end;
-}
-
-static inline void insert_offset2(bam_lidx_t *index2, bam1_t *b, uint64_t offset)
-{
- int i, beg, end;
- beg = b->core.pos >> BAM_LIDX_SHIFT;
- end = (bam_calend(&b->core, bam1_cigar(b)) - 1) >> BAM_LIDX_SHIFT;
- if (index2->m < end + 1) {
- int old_m = index2->m;
- index2->m = end + 1;
- kroundup32(index2->m);
- index2->offset = (uint64_t*)realloc(index2->offset, index2->m * 8);
- memset(index2->offset + old_m, 0, 8 * (index2->m - old_m));
- }
- if (beg == end) {
- if (index2->offset[beg] == 0) index2->offset[beg] = offset;
- } else {
- for (i = beg; i <= end; ++i)
- if (index2->offset[i] == 0) index2->offset[i] = offset;
- }
- index2->n = end + 1;
-}
-
-static void merge_chunks(bam_index_t *idx)
-{
-#if defined(BAM_TRUE_OFFSET) || defined(BAM_VIRTUAL_OFFSET16)
- khash_t(i) *index;
- int i, l, m;
- khint_t k;
- for (i = 0; i < idx->n; ++i) {
- index = idx->index[i];
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- bam_binlist_t *p;
- if (!kh_exist(index, k) || kh_key(index, k) == BAM_MAX_BIN) continue;
- p = &kh_value(index, k);
- m = 0;
- for (l = 1; l < p->n; ++l) {
-#ifdef BAM_TRUE_OFFSET
- if (p->list[m].v + BAM_MIN_CHUNK_GAP > p->list[l].u) p->list[m].v = p->list[l].v;
-#else
- if (p->list[m].v>>16 == p->list[l].u>>16) p->list[m].v = p->list[l].v;
-#endif
- else p->list[++m] = p->list[l];
- } // ~for(l)
- p->n = m + 1;
- } // ~for(k)
- } // ~for(i)
-#endif // defined(BAM_TRUE_OFFSET) || defined(BAM_BGZF)
-}
-
-static void fill_missing(bam_index_t *idx)
-{
- int i, j;
- for (i = 0; i < idx->n; ++i) {
- bam_lidx_t *idx2 = &idx->index2[i];
- for (j = 1; j < idx2->n; ++j)
- if (idx2->offset[j] == 0)
- idx2->offset[j] = idx2->offset[j-1];
- }
-}
-
-bam_index_t *bam_index_core(bamFile fp)
-{
- bam1_t *b;
- bam_header_t *h;
- int i, ret;
- bam_index_t *idx;
- uint32_t last_bin, save_bin;
- int32_t last_coor, last_tid, save_tid;
- bam1_core_t *c;
- uint64_t save_off, last_off, n_mapped, n_unmapped, off_beg, off_end, n_no_coor;
-
- idx = (bam_index_t*)calloc(1, sizeof(bam_index_t));
- b = (bam1_t*)calloc(1, sizeof(bam1_t));
- h = bam_header_read(fp);
- c = &b->core;
-
- idx->n = h->n_targets;
- bam_header_destroy(h);
- idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
- for (i = 0; i < idx->n; ++i) idx->index[i] = kh_init(i);
- idx->index2 = (bam_lidx_t*)calloc(idx->n, sizeof(bam_lidx_t));
-
- save_bin = save_tid = last_tid = last_bin = 0xffffffffu;
- save_off = last_off = bam_tell(fp); last_coor = 0xffffffffu;
- n_mapped = n_unmapped = n_no_coor = off_end = 0;
- off_beg = off_end = bam_tell(fp);
- while ((ret = bam_read1(fp, b)) >= 0) {
- if (c->tid < 0) ++n_no_coor;
- if (last_tid != c->tid) { // change of chromosomes
- last_tid = c->tid;
- last_bin = 0xffffffffu;
- } else if (last_coor > c->pos) {
- fprintf(stderr, "[bam_index_core] the alignment is not sorted (%s): %u > %u in %d-th chr\n",
- bam1_qname(b), last_coor, c->pos, c->tid+1);
- exit(1);
- }
- if (c->tid >= 0) insert_offset2(&idx->index2[b->core.tid], b, last_off);
- if (c->bin != last_bin) { // then possibly write the binning index
- if (save_bin != 0xffffffffu) // save_bin==0xffffffffu only happens to the first record
- insert_offset(idx->index[save_tid], save_bin, save_off, last_off);
- if (last_bin == 0xffffffffu && save_tid != 0xffffffffu) { // write the meta element
- off_end = last_off;
- insert_offset(idx->index[save_tid], BAM_MAX_BIN, off_beg, off_end);
- insert_offset(idx->index[save_tid], BAM_MAX_BIN, n_mapped, n_unmapped);
- n_mapped = n_unmapped = 0;
- off_beg = off_end;
- }
- save_off = last_off;
- save_bin = last_bin = c->bin;
- save_tid = c->tid;
- if (save_tid < 0) break;
- }
- if (bam_tell(fp) <= last_off) {
- fprintf(stderr, "[bam_index_core] bug in BGZF/RAZF: %llx < %llx\n",
- (unsigned long long)bam_tell(fp), (unsigned long long)last_off);
- exit(1);
- }
- if (c->flag & BAM_FUNMAP) ++n_unmapped;
- else ++n_mapped;
- last_off = bam_tell(fp);
- last_coor = b->core.pos;
- }
- if (save_tid >= 0) {
- insert_offset(idx->index[save_tid], save_bin, save_off, bam_tell(fp));
- insert_offset(idx->index[save_tid], BAM_MAX_BIN, off_beg, off_end);
- insert_offset(idx->index[save_tid], BAM_MAX_BIN, n_mapped, n_unmapped);
- }
- merge_chunks(idx);
- fill_missing(idx);
- if (ret >= 0)
- while ((ret = bam_read1(fp, b)) >= 0) ++n_no_coor;
- if (ret < -1) fprintf(stderr, "[bam_index_core] truncated file? Continue anyway. (%d)\n", ret);
- free(b->data); free(b);
- idx->n_no_coor = n_no_coor;
- return idx;
-}
-
-void bam_index_destroy(bam_index_t *idx)
-{
- khint_t k;
- int i;
- if (idx == 0) return;
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index = idx->index[i];
- bam_lidx_t *index2 = idx->index2 + i;
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- if (kh_exist(index, k))
- free(kh_value(index, k).list);
- }
- kh_destroy(i, index);
- free(index2->offset);
- }
- free(idx->index); free(idx->index2);
- free(idx);
-}
-
-void bam_index_save(const bam_index_t *idx, FILE *fp)
-{
- int32_t i, size;
- khint_t k;
- fwrite("BAI\1", 1, 4, fp);
- if (bam_is_be) {
- uint32_t x = idx->n;
- fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
- } else fwrite(&idx->n, 4, 1, fp);
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index = idx->index[i];
- bam_lidx_t *index2 = idx->index2 + i;
- // write binning index
- size = kh_size(index);
- if (bam_is_be) { // big endian
- uint32_t x = size;
- fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
- } else fwrite(&size, 4, 1, fp);
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- if (kh_exist(index, k)) {
- bam_binlist_t *p = &kh_value(index, k);
- if (bam_is_be) { // big endian
- uint32_t x;
- x = kh_key(index, k); fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
- x = p->n; fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
- for (x = 0; (int)x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- fwrite(p->list, 16, p->n, fp);
- for (x = 0; (int)x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- } else {
- fwrite(&kh_key(index, k), 4, 1, fp);
- fwrite(&p->n, 4, 1, fp);
- fwrite(p->list, 16, p->n, fp);
- }
- }
- }
- // write linear index (index2)
- if (bam_is_be) {
- int x = index2->n;
- fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
- } else fwrite(&index2->n, 4, 1, fp);
- if (bam_is_be) { // big endian
- int x;
- for (x = 0; (int)x < index2->n; ++x)
- bam_swap_endian_8p(&index2->offset[x]);
- fwrite(index2->offset, 8, index2->n, fp);
- for (x = 0; (int)x < index2->n; ++x)
- bam_swap_endian_8p(&index2->offset[x]);
- } else fwrite(index2->offset, 8, index2->n, fp);
- }
- { // write the number of reads coor-less records.
- uint64_t x = idx->n_no_coor;
- if (bam_is_be) bam_swap_endian_8p(&x);
- fwrite(&x, 8, 1, fp);
- }
- fflush(fp);
-}
-
-static bam_index_t *bam_index_load_core(FILE *fp)
-{
- int i;
- char magic[4];
- bam_index_t *idx;
- if (fp == 0) {
- fprintf(stderr, "[bam_index_load_core] fail to load index.\n");
- return 0;
- }
- fread(magic, 1, 4, fp);
- if (strncmp(magic, "BAI\1", 4)) {
- fprintf(stderr, "[bam_index_load] wrong magic number.\n");
- fclose(fp);
- return 0;
- }
- idx = (bam_index_t*)calloc(1, sizeof(bam_index_t));
- fread(&idx->n, 4, 1, fp);
- if (bam_is_be) bam_swap_endian_4p(&idx->n);
- idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
- idx->index2 = (bam_lidx_t*)calloc(idx->n, sizeof(bam_lidx_t));
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index;
- bam_lidx_t *index2 = idx->index2 + i;
- uint32_t key, size;
- khint_t k;
- int j, ret;
- bam_binlist_t *p;
- index = idx->index[i] = kh_init(i);
- // load binning index
- fread(&size, 4, 1, fp);
- if (bam_is_be) bam_swap_endian_4p(&size);
- for (j = 0; j < (int)size; ++j) {
- fread(&key, 4, 1, fp);
- if (bam_is_be) bam_swap_endian_4p(&key);
- k = kh_put(i, index, key, &ret);
- p = &kh_value(index, k);
- fread(&p->n, 4, 1, fp);
- if (bam_is_be) bam_swap_endian_4p(&p->n);
- p->m = p->n;
- p->list = (pair64_t*)malloc(p->m * 16);
- fread(p->list, 16, p->n, fp);
- if (bam_is_be) {
- int x;
- for (x = 0; x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- }
- }
- // load linear index
- fread(&index2->n, 4, 1, fp);
- if (bam_is_be) bam_swap_endian_4p(&index2->n);
- index2->m = index2->n;
- index2->offset = (uint64_t*)calloc(index2->m, 8);
- fread(index2->offset, index2->n, 8, fp);
- if (bam_is_be)
- for (j = 0; j < index2->n; ++j) bam_swap_endian_8p(&index2->offset[j]);
- }
- if (fread(&idx->n_no_coor, 8, 1, fp) == 0) idx->n_no_coor = 0;
- if (bam_is_be) bam_swap_endian_8p(&idx->n_no_coor);
- return idx;
-}
-
-bam_index_t *bam_index_load_local(const char *_fn)
-{
- FILE *fp;
- char *fnidx, *fn;
-
- if (strstr(_fn, "ftp://") == _fn || strstr(_fn, "http://") == _fn) {
- const char *p;
- int l = strlen(_fn);
- for (p = _fn + l - 1; p >= _fn; --p)
- if (*p == '/') break;
- fn = strdup(p + 1);
- } else fn = strdup(_fn);
- fnidx = (char*)calloc(strlen(fn) + 5, 1);
- strcpy(fnidx, fn); strcat(fnidx, ".bai");
- fp = fopen(fnidx, "rb");
- if (fp == 0) { // try "{base}.bai"
- char *s = strstr(fn, "bam");
- if (s == fn + strlen(fn) - 3) {
- strcpy(fnidx, fn);
- fnidx[strlen(fn)-1] = 'i';
- fp = fopen(fnidx, "rb");
- }
- }
- free(fnidx); free(fn);
- if (fp) {
- bam_index_t *idx = bam_index_load_core(fp);
- fclose(fp);
- return idx;
- } else return 0;
-}
-
-#ifdef _USE_KNETFILE
-static void download_from_remote(const char *url)
-{
- const int buf_size = 1 * 1024 * 1024;
- char *fn;
- FILE *fp;
- uint8_t *buf;
- knetFile *fp_remote;
- int l;
- if (strstr(url, "ftp://") != url && strstr(url, "http://") != url) return;
- l = strlen(url);
- for (fn = (char*)url + l - 1; fn >= url; --fn)
- if (*fn == '/') break;
- ++fn; // fn now points to the file name
- fp_remote = knet_open(url, "r");
- if (fp_remote == 0) {
- fprintf(stderr, "[download_from_remote] fail to open remote file.\n");
- return;
- }
- if ((fp = fopen(fn, "wb")) == 0) {
- fprintf(stderr, "[download_from_remote] fail to create file in the working directory.\n");
- knet_close(fp_remote);
- return;
- }
- buf = (uint8_t*)calloc(buf_size, 1);
- while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
- fwrite(buf, 1, l, fp);
- free(buf);
- fclose(fp);
- knet_close(fp_remote);
-}
-#else
-static void download_from_remote(const char *url)
-{
- return;
-}
-#endif
-
-bam_index_t *bam_index_load(const char *fn)
-{
- bam_index_t *idx;
- idx = bam_index_load_local(fn);
- if (idx == 0 && (strstr(fn, "ftp://") == fn || strstr(fn, "http://") == fn)) {
- char *fnidx = calloc(strlen(fn) + 5, 1);
- strcat(strcpy(fnidx, fn), ".bai");
- fprintf(stderr, "[bam_index_load] attempting to download the remote index file.\n");
- download_from_remote(fnidx);
- idx = bam_index_load_local(fn);
- }
- if (idx == 0) fprintf(stderr, "[bam_index_load] fail to load BAM index.\n");
- return idx;
-}
-
-int bam_index_build2(const char *fn, const char *_fnidx)
-{
- char *fnidx;
- FILE *fpidx;
- bamFile fp;
- bam_index_t *idx;
- if ((fp = bam_open(fn, "r")) == 0) {
- fprintf(stderr, "[bam_index_build2] fail to open the BAM file.\n");
- return -1;
- }
- idx = bam_index_core(fp);
- bam_close(fp);
- if (_fnidx == 0) {
- fnidx = (char*)calloc(strlen(fn) + 5, 1);
- strcpy(fnidx, fn); strcat(fnidx, ".bai");
- } else fnidx = strdup(_fnidx);
- fpidx = fopen(fnidx, "wb");
- if (fpidx == 0) {
- fprintf(stderr, "[bam_index_build2] fail to create the index file.\n");
- free(fnidx);
- return -1;
- }
- bam_index_save(idx, fpidx);
- bam_index_destroy(idx);
- fclose(fpidx);
- free(fnidx);
- return 0;
-}
-
-int bam_index_build(const char *fn)
-{
- return bam_index_build2(fn, 0);
-}
-
-int bam_index(int argc, char *argv[])
-{
- if (argc < 2) {
- fprintf(stderr, "Usage: samtools index <in.bam> [out.index]\n");
- return 1;
- }
- if (argc >= 3) bam_index_build2(argv[1], argv[2]);
- else bam_index_build(argv[1]);
- return 0;
-}
-
-int bam_idxstats(int argc, char *argv[])
-{
- bam_index_t *idx;
- bam_header_t *header;
- bamFile fp;
- int i;
- if (argc < 2) {
- fprintf(stderr, "Usage: samtools idxstats <in.bam>\n");
- return 1;
- }
- fp = bam_open(argv[1], "r");
- if (fp == 0) { fprintf(stderr, "[%s] fail to open BAM.\n", __func__); return 1; }
- header = bam_header_read(fp);
- bam_close(fp);
- idx = bam_index_load(argv[1]);
- if (idx == 0) { fprintf(stderr, "[%s] fail to load the index.\n", __func__); return 1; }
- for (i = 0; i < idx->n; ++i) {
- khint_t k;
- khash_t(i) *h = idx->index[i];
- printf("%s\t%d", header->target_name[i], header->target_len[i]);
- k = kh_get(i, h, BAM_MAX_BIN);
- if (k != kh_end(h))
- printf("\t%llu\t%llu", (long long)kh_val(h, k).list[1].u, (long long)kh_val(h, k).list[1].v);
- else printf("\t0\t0");
- putchar('\n');
- }
- printf("*\t0\t0\t%llu\n", (long long)idx->n_no_coor);
- bam_header_destroy(header);
- bam_index_destroy(idx);
- return 0;
-}
-
-static inline int reg2bins(uint32_t beg, uint32_t end, uint16_t list[BAM_MAX_BIN])
-{
- int i = 0, k;
- if (beg >= end) return 0;
- if (end >= 1u<<29) end = 1u<<29;
- --end;
- list[i++] = 0;
- for (k = 1 + (beg>>26); k <= 1 + (end>>26); ++k) list[i++] = k;
- for (k = 9 + (beg>>23); k <= 9 + (end>>23); ++k) list[i++] = k;
- for (k = 73 + (beg>>20); k <= 73 + (end>>20); ++k) list[i++] = k;
- for (k = 585 + (beg>>17); k <= 585 + (end>>17); ++k) list[i++] = k;
- for (k = 4681 + (beg>>14); k <= 4681 + (end>>14); ++k) list[i++] = k;
- return i;
-}
-
-static inline int is_overlap(uint32_t beg, uint32_t end, const bam1_t *b)
-{
- uint32_t rbeg = b->core.pos;
- uint32_t rend = b->core.n_cigar? bam_calend(&b->core, bam1_cigar(b)) : b->core.pos + 1;
- return (rend > beg && rbeg < end);
-}
-
-struct __bam_iter_t {
- int from_first; // read from the first record; no random access
- int tid, beg, end, n_off, i, finished;
- uint64_t curr_off;
- pair64_t *off;
-};
-
-// bam_fetch helper function retrieves
-bam_iter_t bam_iter_query(const bam_index_t *idx, int tid, int beg, int end)
-{
- uint16_t *bins;
- int i, n_bins, n_off;
- pair64_t *off;
- khint_t k;
- khash_t(i) *index;
- uint64_t min_off;
- bam_iter_t iter = 0;
-
- if (beg < 0) beg = 0;
- if (end < beg) return 0;
- // initialize iter
- iter = calloc(1, sizeof(struct __bam_iter_t));
- iter->tid = tid, iter->beg = beg, iter->end = end; iter->i = -1;
- //
- bins = (uint16_t*)calloc(BAM_MAX_BIN, 2);
- n_bins = reg2bins(beg, end, bins);
- index = idx->index[tid];
- if (idx->index2[tid].n > 0) {
- min_off = (beg>>BAM_LIDX_SHIFT >= idx->index2[tid].n)? idx->index2[tid].offset[idx->index2[tid].n-1]
- : idx->index2[tid].offset[beg>>BAM_LIDX_SHIFT];
- if (min_off == 0) { // improvement for index files built by tabix prior to 0.1.4
- int n = beg>>BAM_LIDX_SHIFT;
- if (n > idx->index2[tid].n) n = idx->index2[tid].n;
- for (i = n - 1; i >= 0; --i)
- if (idx->index2[tid].offset[i] != 0) break;
- if (i >= 0) min_off = idx->index2[tid].offset[i];
- }
- } else min_off = 0; // tabix 0.1.2 may produce such index files
- for (i = n_off = 0; i < n_bins; ++i) {
- if ((k = kh_get(i, index, bins[i])) != kh_end(index))
- n_off += kh_value(index, k).n;
- }
- if (n_off == 0) {
- free(bins); return iter;
- }
- off = (pair64_t*)calloc(n_off, 16);
- for (i = n_off = 0; i < n_bins; ++i) {
- if ((k = kh_get(i, index, bins[i])) != kh_end(index)) {
- int j;
- bam_binlist_t *p = &kh_value(index, k);
- for (j = 0; j < p->n; ++j)
- if (p->list[j].v > min_off) off[n_off++] = p->list[j];
- }
- }
- free(bins);
- {
- bam1_t *b = (bam1_t*)calloc(1, sizeof(bam1_t));
- int l;
- ks_introsort(off, n_off, off);
- // resolve completely contained adjacent blocks
- for (i = 1, l = 0; i < n_off; ++i)
- if (off[l].v < off[i].v)
- off[++l] = off[i];
- n_off = l + 1;
- // resolve overlaps between adjacent blocks; this may happen due to the merge in indexing
- for (i = 1; i < n_off; ++i)
- if (off[i-1].v >= off[i].u) off[i-1].v = off[i].u;
- { // merge adjacent blocks
-#if defined(BAM_TRUE_OFFSET) || defined(BAM_VIRTUAL_OFFSET16)
- for (i = 1, l = 0; i < n_off; ++i) {
-#ifdef BAM_TRUE_OFFSET
- if (off[l].v + BAM_MIN_CHUNK_GAP > off[i].u) off[l].v = off[i].v;
-#else
- if (off[l].v>>16 == off[i].u>>16) off[l].v = off[i].v;
-#endif
- else off[++l] = off[i];
- }
- n_off = l + 1;
-#endif
- }
- bam_destroy1(b);
- }
- iter->n_off = n_off; iter->off = off;
- return iter;
-}
-
-pair64_t *get_chunk_coordinates(const bam_index_t *idx, int tid, int beg, int end, int *cnt_off)
-{ // for pysam compatibility
- bam_iter_t iter;
- pair64_t *off;
- iter = bam_iter_query(idx, tid, beg, end);
- off = iter->off; *cnt_off = iter->n_off;
- free(iter);
- return off;
-}
-
-void bam_iter_destroy(bam_iter_t iter)
-{
- if (iter) { free(iter->off); free(iter); }
-}
-
-int bam_iter_read(bamFile fp, bam_iter_t iter, bam1_t *b)
-{
- if (iter->finished) return -1;
- if (iter->from_first) {
- int ret = bam_read1(fp, b);
- if (ret < 0) iter->finished = 1;
- return ret;
- }
- if (iter->off == 0) return -1;
- for (;;) {
- int ret;
- if (iter->curr_off == 0 || iter->curr_off >= iter->off[iter->i].v) { // then jump to the next chunk
- if (iter->i == iter->n_off - 1) break; // no more chunks
- if (iter->i >= 0) assert(iter->curr_off == iter->off[iter->i].v); // otherwise bug
- if (iter->i < 0 || iter->off[iter->i].v != iter->off[iter->i+1].u) { // not adjacent chunks; then seek
- bam_seek(fp, iter->off[iter->i+1].u, SEEK_SET);
- iter->curr_off = bam_tell(fp);
- }
- ++iter->i;
- }
- if ((ret = bam_read1(fp, b)) > 0) {
- iter->curr_off = bam_tell(fp);
- if (b->core.tid != iter->tid || b->core.pos >= iter->end) break; // no need to proceed
- else if (is_overlap(iter->beg, iter->end, b)) return ret;
- } else break; // end of file
- }
- iter->finished = 1;
- return -1;
-}
-
-int bam_fetch(bamFile fp, const bam_index_t *idx, int tid, int beg, int end, void *data, bam_fetch_f func)
-{
- bam_iter_t iter;
- bam1_t *b;
- b = bam_init1();
- iter = bam_iter_query(idx, tid, beg, end);
- while (bam_iter_read(fp, iter, b) >= 0) func(b, data);
- bam_destroy1(b);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <ctype.h>
+#include <assert.h>
+#include "bam.h"
+#include "khash.h"
+#include "ksort.h"
+#include "bam_endian.h"
+#ifdef _USE_KNETFILE
+#include "knetfile.h"
+#endif
+
+/*!
+ @header
+
+ Alignment indexing. Before indexing, BAM must be sorted based on the
+ leftmost coordinate of alignments. In indexing, BAM uses two indices:
+ a UCSC binning index and a simple linear index. The binning index is
+ efficient for alignments spanning long distance, while the auxiliary
+ linear index helps to reduce unnecessary seek calls especially for
+ short alignments.
+
+ The UCSC binning scheme was suggested by Richard Durbin and Lincoln
+ Stein and is explained by Kent et al. (2002). In this scheme, each bin
+ represents a contiguous genomic region which can be fully contained in
+ another bin; each alignment is associated with a bin which represents
+ the smallest region containing the entire alignment. The binning
+ scheme is essentially another representation of R-tree. A distinct bin
+ uniquely corresponds to a distinct internal node in a R-tree. Bin A is
+ a child of Bin B if region A is contained in B.
+
+ In BAM, each bin may span 2^29, 2^26, 2^23, 2^20, 2^17 or 2^14 bp. Bin
+ 0 spans a 512Mbp region, bins 1-8 span 64Mbp, 9-72 8Mbp, 73-584 1Mbp,
+ 585-4680 128Kbp and bins 4681-37449 span 16Kbp regions. If we want to
+ find the alignments overlapped with a region [rbeg,rend), we need to
+ calculate the list of bins that may be overlapped the region and test
+ the alignments in the bins to confirm the overlaps. If the specified
+ region is short, typically only a few alignments in six bins need to
+ be retrieved. The overlapping alignments can be quickly fetched.
+
+ */
+
+#define BAM_MIN_CHUNK_GAP 32768
+// 1<<14 is the size of minimum bin.
+#define BAM_LIDX_SHIFT 14
+
+#define BAM_MAX_BIN 37450 // =(8^6-1)/7+1
+
+typedef struct {
+ uint64_t u, v;
+} pair64_t;
+
+#define pair64_lt(a,b) ((a).u < (b).u)
+KSORT_INIT(off, pair64_t, pair64_lt)
+
+typedef struct {
+ uint32_t m, n;
+ pair64_t *list;
+} bam_binlist_t;
+
+typedef struct {
+ int32_t n, m;
+ uint64_t *offset;
+} bam_lidx_t;
+
+KHASH_MAP_INIT_INT(i, bam_binlist_t)
+
+struct __bam_index_t {
+ int32_t n;
+ uint64_t n_no_coor; // unmapped reads without coordinate
+ khash_t(i) **index;
+ bam_lidx_t *index2;
+};
+
+// requirement: len <= LEN_MASK
+static inline void insert_offset(khash_t(i) *h, int bin, uint64_t beg, uint64_t end)
+{
+ khint_t k;
+ bam_binlist_t *l;
+ int ret;
+ k = kh_put(i, h, bin, &ret);
+ l = &kh_value(h, k);
+ if (ret) { // not present
+ l->m = 1; l->n = 0;
+ l->list = (pair64_t*)calloc(l->m, 16);
+ }
+ if (l->n == l->m) {
+ l->m <<= 1;
+ l->list = (pair64_t*)realloc(l->list, l->m * 16);
+ }
+ l->list[l->n].u = beg; l->list[l->n++].v = end;
+}
+
+static inline void insert_offset2(bam_lidx_t *index2, bam1_t *b, uint64_t offset)
+{
+ int i, beg, end;
+ beg = b->core.pos >> BAM_LIDX_SHIFT;
+ end = (bam_calend(&b->core, bam1_cigar(b)) - 1) >> BAM_LIDX_SHIFT;
+ if (index2->m < end + 1) {
+ int old_m = index2->m;
+ index2->m = end + 1;
+ kroundup32(index2->m);
+ index2->offset = (uint64_t*)realloc(index2->offset, index2->m * 8);
+ memset(index2->offset + old_m, 0, 8 * (index2->m - old_m));
+ }
+ if (beg == end) {
+ if (index2->offset[beg] == 0) index2->offset[beg] = offset;
+ } else {
+ for (i = beg; i <= end; ++i)
+ if (index2->offset[i] == 0) index2->offset[i] = offset;
+ }
+ index2->n = end + 1;
+}
+
+static void merge_chunks(bam_index_t *idx)
+{
+#if defined(BAM_TRUE_OFFSET) || defined(BAM_VIRTUAL_OFFSET16)
+ khash_t(i) *index;
+ int i, l, m;
+ khint_t k;
+ for (i = 0; i < idx->n; ++i) {
+ index = idx->index[i];
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ bam_binlist_t *p;
+ if (!kh_exist(index, k) || kh_key(index, k) == BAM_MAX_BIN) continue;
+ p = &kh_value(index, k);
+ m = 0;
+ for (l = 1; l < p->n; ++l) {
+#ifdef BAM_TRUE_OFFSET
+ if (p->list[m].v + BAM_MIN_CHUNK_GAP > p->list[l].u) p->list[m].v = p->list[l].v;
+#else
+ if (p->list[m].v>>16 == p->list[l].u>>16) p->list[m].v = p->list[l].v;
+#endif
+ else p->list[++m] = p->list[l];
+ } // ~for(l)
+ p->n = m + 1;
+ } // ~for(k)
+ } // ~for(i)
+#endif // defined(BAM_TRUE_OFFSET) || defined(BAM_BGZF)
+}
+
+static void fill_missing(bam_index_t *idx)
+{
+ int i, j;
+ for (i = 0; i < idx->n; ++i) {
+ bam_lidx_t *idx2 = &idx->index2[i];
+ for (j = 1; j < idx2->n; ++j)
+ if (idx2->offset[j] == 0)
+ idx2->offset[j] = idx2->offset[j-1];
+ }
+}
+
+bam_index_t *bam_index_core(bamFile fp)
+{
+ bam1_t *b;
+ bam_header_t *h;
+ int i, ret;
+ bam_index_t *idx;
+ uint32_t last_bin, save_bin;
+ int32_t last_coor, last_tid, save_tid;
+ bam1_core_t *c;
+ uint64_t save_off, last_off, n_mapped, n_unmapped, off_beg, off_end, n_no_coor;
+
+ idx = (bam_index_t*)calloc(1, sizeof(bam_index_t));
+ b = (bam1_t*)calloc(1, sizeof(bam1_t));
+ h = bam_header_read(fp);
+ c = &b->core;
+
+ idx->n = h->n_targets;
+ bam_header_destroy(h);
+ idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
+ for (i = 0; i < idx->n; ++i) idx->index[i] = kh_init(i);
+ idx->index2 = (bam_lidx_t*)calloc(idx->n, sizeof(bam_lidx_t));
+
+ save_bin = save_tid = last_tid = last_bin = 0xffffffffu;
+ save_off = last_off = bam_tell(fp); last_coor = 0xffffffffu;
+ n_mapped = n_unmapped = n_no_coor = off_end = 0;
+ off_beg = off_end = bam_tell(fp);
+ while ((ret = bam_read1(fp, b)) >= 0) {
+ if (c->tid < 0) ++n_no_coor;
+ if (last_tid != c->tid) { // change of chromosomes
+ last_tid = c->tid;
+ last_bin = 0xffffffffu;
+ } else if (last_coor > c->pos) {
+ fprintf(pysamerr, "[bam_index_core] the alignment is not sorted (%s): %u > %u in %d-th chr\n",
+ bam1_qname(b), last_coor, c->pos, c->tid+1);
+ exit(1);
+ }
+ if (c->tid >= 0) insert_offset2(&idx->index2[b->core.tid], b, last_off);
+ if (c->bin != last_bin) { // then possibly write the binning index
+ if (save_bin != 0xffffffffu) // save_bin==0xffffffffu only happens to the first record
+ insert_offset(idx->index[save_tid], save_bin, save_off, last_off);
+ if (last_bin == 0xffffffffu && save_tid != 0xffffffffu) { // write the meta element
+ off_end = last_off;
+ insert_offset(idx->index[save_tid], BAM_MAX_BIN, off_beg, off_end);
+ insert_offset(idx->index[save_tid], BAM_MAX_BIN, n_mapped, n_unmapped);
+ n_mapped = n_unmapped = 0;
+ off_beg = off_end;
+ }
+ save_off = last_off;
+ save_bin = last_bin = c->bin;
+ save_tid = c->tid;
+ if (save_tid < 0) break;
+ }
+ if (bam_tell(fp) <= last_off) {
+ fprintf(pysamerr, "[bam_index_core] bug in BGZF/RAZF: %llx < %llx\n",
+ (unsigned long long)bam_tell(fp), (unsigned long long)last_off);
+ exit(1);
+ }
+ if (c->flag & BAM_FUNMAP) ++n_unmapped;
+ else ++n_mapped;
+ last_off = bam_tell(fp);
+ last_coor = b->core.pos;
+ }
+ if (save_tid >= 0) {
+ insert_offset(idx->index[save_tid], save_bin, save_off, bam_tell(fp));
+ insert_offset(idx->index[save_tid], BAM_MAX_BIN, off_beg, bam_tell(fp));
+ insert_offset(idx->index[save_tid], BAM_MAX_BIN, n_mapped, n_unmapped);
+ }
+ merge_chunks(idx);
+ fill_missing(idx);
+ if (ret >= 0) {
+ while ((ret = bam_read1(fp, b)) >= 0) {
+ ++n_no_coor;
+ if (c->tid >= 0 && n_no_coor) {
+ fprintf(pysamerr, "[bam_index_core] the alignment is not sorted: reads without coordinates prior to reads with coordinates.\n");
+ exit(1);
+ }
+ }
+ }
+ if (ret < -1) fprintf(pysamerr, "[bam_index_core] truncated file? Continue anyway. (%d)\n", ret);
+ free(b->data); free(b);
+ idx->n_no_coor = n_no_coor;
+ return idx;
+}
+
+void bam_index_destroy(bam_index_t *idx)
+{
+ khint_t k;
+ int i;
+ if (idx == 0) return;
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index = idx->index[i];
+ bam_lidx_t *index2 = idx->index2 + i;
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ if (kh_exist(index, k))
+ free(kh_value(index, k).list);
+ }
+ kh_destroy(i, index);
+ free(index2->offset);
+ }
+ free(idx->index); free(idx->index2);
+ free(idx);
+}
+
+void bam_index_save(const bam_index_t *idx, FILE *fp)
+{
+ int32_t i, size;
+ khint_t k;
+ fwrite("BAI\1", 1, 4, fp);
+ if (bam_is_be) {
+ uint32_t x = idx->n;
+ fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
+ } else fwrite(&idx->n, 4, 1, fp);
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index = idx->index[i];
+ bam_lidx_t *index2 = idx->index2 + i;
+ // write binning index
+ size = kh_size(index);
+ if (bam_is_be) { // big endian
+ uint32_t x = size;
+ fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
+ } else fwrite(&size, 4, 1, fp);
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ if (kh_exist(index, k)) {
+ bam_binlist_t *p = &kh_value(index, k);
+ if (bam_is_be) { // big endian
+ uint32_t x;
+ x = kh_key(index, k); fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
+ x = p->n; fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
+ for (x = 0; (int)x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ fwrite(p->list, 16, p->n, fp);
+ for (x = 0; (int)x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ } else {
+ fwrite(&kh_key(index, k), 4, 1, fp);
+ fwrite(&p->n, 4, 1, fp);
+ fwrite(p->list, 16, p->n, fp);
+ }
+ }
+ }
+ // write linear index (index2)
+ if (bam_is_be) {
+ int x = index2->n;
+ fwrite(bam_swap_endian_4p(&x), 4, 1, fp);
+ } else fwrite(&index2->n, 4, 1, fp);
+ if (bam_is_be) { // big endian
+ int x;
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ fwrite(index2->offset, 8, index2->n, fp);
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ } else fwrite(index2->offset, 8, index2->n, fp);
+ }
+ { // write the number of reads coor-less records.
+ uint64_t x = idx->n_no_coor;
+ if (bam_is_be) bam_swap_endian_8p(&x);
+ fwrite(&x, 8, 1, fp);
+ }
+ fflush(fp);
+}
+
+static bam_index_t *bam_index_load_core(FILE *fp)
+{
+ int i;
+ char magic[4];
+ bam_index_t *idx;
+ if (fp == 0) {
+ fprintf(pysamerr, "[bam_index_load_core] fail to load index.\n");
+ return 0;
+ }
+ fread(magic, 1, 4, fp);
+ if (strncmp(magic, "BAI\1", 4)) {
+ fprintf(pysamerr, "[bam_index_load] wrong magic number.\n");
+ fclose(fp);
+ return 0;
+ }
+ idx = (bam_index_t*)calloc(1, sizeof(bam_index_t));
+ fread(&idx->n, 4, 1, fp);
+ if (bam_is_be) bam_swap_endian_4p(&idx->n);
+ idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
+ idx->index2 = (bam_lidx_t*)calloc(idx->n, sizeof(bam_lidx_t));
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index;
+ bam_lidx_t *index2 = idx->index2 + i;
+ uint32_t key, size;
+ khint_t k;
+ int j, ret;
+ bam_binlist_t *p;
+ index = idx->index[i] = kh_init(i);
+ // load binning index
+ fread(&size, 4, 1, fp);
+ if (bam_is_be) bam_swap_endian_4p(&size);
+ for (j = 0; j < (int)size; ++j) {
+ fread(&key, 4, 1, fp);
+ if (bam_is_be) bam_swap_endian_4p(&key);
+ k = kh_put(i, index, key, &ret);
+ p = &kh_value(index, k);
+ fread(&p->n, 4, 1, fp);
+ if (bam_is_be) bam_swap_endian_4p(&p->n);
+ p->m = p->n;
+ p->list = (pair64_t*)malloc(p->m * 16);
+ fread(p->list, 16, p->n, fp);
+ if (bam_is_be) {
+ int x;
+ for (x = 0; x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ }
+ }
+ // load linear index
+ fread(&index2->n, 4, 1, fp);
+ if (bam_is_be) bam_swap_endian_4p(&index2->n);
+ index2->m = index2->n;
+ index2->offset = (uint64_t*)calloc(index2->m, 8);
+ fread(index2->offset, index2->n, 8, fp);
+ if (bam_is_be)
+ for (j = 0; j < index2->n; ++j) bam_swap_endian_8p(&index2->offset[j]);
+ }
+ if (fread(&idx->n_no_coor, 8, 1, fp) == 0) idx->n_no_coor = 0;
+ if (bam_is_be) bam_swap_endian_8p(&idx->n_no_coor);
+ return idx;
+}
+
+bam_index_t *bam_index_load_local(const char *_fn)
+{
+ FILE *fp;
+ char *fnidx, *fn;
+
+ if (strstr(_fn, "ftp://") == _fn || strstr(_fn, "http://") == _fn) {
+ const char *p;
+ int l = strlen(_fn);
+ for (p = _fn + l - 1; p >= _fn; --p)
+ if (*p == '/') break;
+ fn = strdup(p + 1);
+ } else fn = strdup(_fn);
+ fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcpy(fnidx, fn); strcat(fnidx, ".bai");
+ fp = fopen(fnidx, "rb");
+ if (fp == 0) { // try "{base}.bai"
+ char *s = strstr(fn, "bam");
+ if (s == fn + strlen(fn) - 3) {
+ strcpy(fnidx, fn);
+ fnidx[strlen(fn)-1] = 'i';
+ fp = fopen(fnidx, "rb");
+ }
+ }
+ free(fnidx); free(fn);
+ if (fp) {
+ bam_index_t *idx = bam_index_load_core(fp);
+ fclose(fp);
+ return idx;
+ } else return 0;
+}
+
+#ifdef _USE_KNETFILE
+static void download_from_remote(const char *url)
+{
+ const int buf_size = 1 * 1024 * 1024;
+ char *fn;
+ FILE *fp;
+ uint8_t *buf;
+ knetFile *fp_remote;
+ int l;
+ if (strstr(url, "ftp://") != url && strstr(url, "http://") != url) return;
+ l = strlen(url);
+ for (fn = (char*)url + l - 1; fn >= url; --fn)
+ if (*fn == '/') break;
+ ++fn; // fn now points to the file name
+ fp_remote = knet_open(url, "r");
+ if (fp_remote == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to open remote file.\n");
+ return;
+ }
+ if ((fp = fopen(fn, "wb")) == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to create file in the working directory.\n");
+ knet_close(fp_remote);
+ return;
+ }
+ buf = (uint8_t*)calloc(buf_size, 1);
+ while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
+ fwrite(buf, 1, l, fp);
+ free(buf);
+ fclose(fp);
+ knet_close(fp_remote);
+}
+#else
+static void download_from_remote(const char *url)
+{
+ return;
+}
+#endif
+
+bam_index_t *bam_index_load(const char *fn)
+{
+ bam_index_t *idx;
+ idx = bam_index_load_local(fn);
+ if (idx == 0 && (strstr(fn, "ftp://") == fn || strstr(fn, "http://") == fn)) {
+ char *fnidx = calloc(strlen(fn) + 5, 1);
+ strcat(strcpy(fnidx, fn), ".bai");
+ fprintf(pysamerr, "[bam_index_load] attempting to download the remote index file.\n");
+ download_from_remote(fnidx);
+ idx = bam_index_load_local(fn);
+ }
+ if (idx == 0) fprintf(pysamerr, "[bam_index_load] fail to load BAM index.\n");
+ return idx;
+}
+
+int bam_index_build2(const char *fn, const char *_fnidx)
+{
+ char *fnidx;
+ FILE *fpidx;
+ bamFile fp;
+ bam_index_t *idx;
+ if ((fp = bam_open(fn, "r")) == 0) {
+ fprintf(pysamerr, "[bam_index_build2] fail to open the BAM file.\n");
+ return -1;
+ }
+ idx = bam_index_core(fp);
+ bam_close(fp);
+ if (_fnidx == 0) {
+ fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcpy(fnidx, fn); strcat(fnidx, ".bai");
+ } else fnidx = strdup(_fnidx);
+ fpidx = fopen(fnidx, "wb");
+ if (fpidx == 0) {
+ fprintf(pysamerr, "[bam_index_build2] fail to create the index file.\n");
+ free(fnidx);
+ return -1;
+ }
+ bam_index_save(idx, fpidx);
+ bam_index_destroy(idx);
+ fclose(fpidx);
+ free(fnidx);
+ return 0;
+}
+
+int bam_index_build(const char *fn)
+{
+ return bam_index_build2(fn, 0);
+}
+
+int bam_index(int argc, char *argv[])
+{
+ if (argc < 2) {
+ fprintf(pysamerr, "Usage: samtools index <in.bam> [out.index]\n");
+ return 1;
+ }
+ if (argc >= 3) bam_index_build2(argv[1], argv[2]);
+ else bam_index_build(argv[1]);
+ return 0;
+}
+
+int bam_idxstats(int argc, char *argv[])
+{
+ bam_index_t *idx;
+ bam_header_t *header;
+ bamFile fp;
+ int i;
+ if (argc < 2) {
+ fprintf(pysamerr, "Usage: samtools idxstats <in.bam>\n");
+ return 1;
+ }
+ fp = bam_open(argv[1], "r");
+ if (fp == 0) { fprintf(pysamerr, "[%s] fail to open BAM.\n", __func__); return 1; }
+ header = bam_header_read(fp);
+ bam_close(fp);
+ idx = bam_index_load(argv[1]);
+ if (idx == 0) { fprintf(pysamerr, "[%s] fail to load the index.\n", __func__); return 1; }
+ for (i = 0; i < idx->n; ++i) {
+ khint_t k;
+ khash_t(i) *h = idx->index[i];
+ printf("%s\t%d", header->target_name[i], header->target_len[i]);
+ k = kh_get(i, h, BAM_MAX_BIN);
+ if (k != kh_end(h))
+ printf("\t%llu\t%llu", (long long)kh_val(h, k).list[1].u, (long long)kh_val(h, k).list[1].v);
+ else printf("\t0\t0");
+ putchar('\n');
+ }
+ printf("*\t0\t0\t%llu\n", (long long)idx->n_no_coor);
+ bam_header_destroy(header);
+ bam_index_destroy(idx);
+ return 0;
+}
+
+static inline int reg2bins(uint32_t beg, uint32_t end, uint16_t list[BAM_MAX_BIN])
+{
+ int i = 0, k;
+ if (beg >= end) return 0;
+ if (end >= 1u<<29) end = 1u<<29;
+ --end;
+ list[i++] = 0;
+ for (k = 1 + (beg>>26); k <= 1 + (end>>26); ++k) list[i++] = k;
+ for (k = 9 + (beg>>23); k <= 9 + (end>>23); ++k) list[i++] = k;
+ for (k = 73 + (beg>>20); k <= 73 + (end>>20); ++k) list[i++] = k;
+ for (k = 585 + (beg>>17); k <= 585 + (end>>17); ++k) list[i++] = k;
+ for (k = 4681 + (beg>>14); k <= 4681 + (end>>14); ++k) list[i++] = k;
+ return i;
+}
+
+static inline int is_overlap(uint32_t beg, uint32_t end, const bam1_t *b)
+{
+ uint32_t rbeg = b->core.pos;
+ uint32_t rend = b->core.n_cigar? bam_calend(&b->core, bam1_cigar(b)) : b->core.pos + 1;
+ return (rend > beg && rbeg < end);
+}
+
+struct __bam_iter_t {
+ int from_first; // read from the first record; no random access
+ int tid, beg, end, n_off, i, finished;
+ uint64_t curr_off;
+ pair64_t *off;
+};
+
+// bam_fetch helper function retrieves
+bam_iter_t bam_iter_query(const bam_index_t *idx, int tid, int beg, int end)
+{
+ uint16_t *bins;
+ int i, n_bins, n_off;
+ pair64_t *off;
+ khint_t k;
+ khash_t(i) *index;
+ uint64_t min_off;
+ bam_iter_t iter = 0;
+
+ if (beg < 0) beg = 0;
+ if (end < beg) return 0;
+ // initialize iter
+ iter = calloc(1, sizeof(struct __bam_iter_t));
+ iter->tid = tid, iter->beg = beg, iter->end = end; iter->i = -1;
+ //
+ bins = (uint16_t*)calloc(BAM_MAX_BIN, 2);
+ n_bins = reg2bins(beg, end, bins);
+ index = idx->index[tid];
+ if (idx->index2[tid].n > 0) {
+ min_off = (beg>>BAM_LIDX_SHIFT >= idx->index2[tid].n)? idx->index2[tid].offset[idx->index2[tid].n-1]
+ : idx->index2[tid].offset[beg>>BAM_LIDX_SHIFT];
+ if (min_off == 0) { // improvement for index files built by tabix prior to 0.1.4
+ int n = beg>>BAM_LIDX_SHIFT;
+ if (n > idx->index2[tid].n) n = idx->index2[tid].n;
+ for (i = n - 1; i >= 0; --i)
+ if (idx->index2[tid].offset[i] != 0) break;
+ if (i >= 0) min_off = idx->index2[tid].offset[i];
+ }
+ } else min_off = 0; // tabix 0.1.2 may produce such index files
+ for (i = n_off = 0; i < n_bins; ++i) {
+ if ((k = kh_get(i, index, bins[i])) != kh_end(index))
+ n_off += kh_value(index, k).n;
+ }
+ if (n_off == 0) {
+ free(bins); return iter;
+ }
+ off = (pair64_t*)calloc(n_off, 16);
+ for (i = n_off = 0; i < n_bins; ++i) {
+ if ((k = kh_get(i, index, bins[i])) != kh_end(index)) {
+ int j;
+ bam_binlist_t *p = &kh_value(index, k);
+ for (j = 0; j < p->n; ++j)
+ if (p->list[j].v > min_off) off[n_off++] = p->list[j];
+ }
+ }
+ free(bins);
+ if (n_off == 0) {
+ free(off); return iter;
+ }
+ {
+ bam1_t *b = (bam1_t*)calloc(1, sizeof(bam1_t));
+ int l;
+ ks_introsort(off, n_off, off);
+ // resolve completely contained adjacent blocks
+ for (i = 1, l = 0; i < n_off; ++i)
+ if (off[l].v < off[i].v)
+ off[++l] = off[i];
+ n_off = l + 1;
+ // resolve overlaps between adjacent blocks; this may happen due to the merge in indexing
+ for (i = 1; i < n_off; ++i)
+ if (off[i-1].v >= off[i].u) off[i-1].v = off[i].u;
+ { // merge adjacent blocks
+#if defined(BAM_TRUE_OFFSET) || defined(BAM_VIRTUAL_OFFSET16)
+ for (i = 1, l = 0; i < n_off; ++i) {
+#ifdef BAM_TRUE_OFFSET
+ if (off[l].v + BAM_MIN_CHUNK_GAP > off[i].u) off[l].v = off[i].v;
+#else
+ if (off[l].v>>16 == off[i].u>>16) off[l].v = off[i].v;
+#endif
+ else off[++l] = off[i];
+ }
+ n_off = l + 1;
+#endif
+ }
+ bam_destroy1(b);
+ }
+ iter->n_off = n_off; iter->off = off;
+ return iter;
+}
+
+pair64_t *get_chunk_coordinates(const bam_index_t *idx, int tid, int beg, int end, int *cnt_off)
+{ // for pysam compatibility
+ bam_iter_t iter;
+ pair64_t *off;
+ iter = bam_iter_query(idx, tid, beg, end);
+ off = iter->off; *cnt_off = iter->n_off;
+ free(iter);
+ return off;
+}
+
+void bam_iter_destroy(bam_iter_t iter)
+{
+ if (iter) { free(iter->off); free(iter); }
+}
+
+int bam_iter_read(bamFile fp, bam_iter_t iter, bam1_t *b)
+{
+ int ret;
+ if (iter && iter->finished) return -1;
+ if (iter == 0 || iter->from_first) {
+ ret = bam_read1(fp, b);
+ if (ret < 0 && iter) iter->finished = 1;
+ return ret;
+ }
+ if (iter->off == 0) return -1;
+ for (;;) {
+ if (iter->curr_off == 0 || iter->curr_off >= iter->off[iter->i].v) { // then jump to the next chunk
+ if (iter->i == iter->n_off - 1) { ret = -1; break; } // no more chunks
+ if (iter->i >= 0) assert(iter->curr_off == iter->off[iter->i].v); // otherwise bug
+ if (iter->i < 0 || iter->off[iter->i].v != iter->off[iter->i+1].u) { // not adjacent chunks; then seek
+ bam_seek(fp, iter->off[iter->i+1].u, SEEK_SET);
+ iter->curr_off = bam_tell(fp);
+ }
+ ++iter->i;
+ }
+ if ((ret = bam_read1(fp, b)) >= 0) {
+ iter->curr_off = bam_tell(fp);
+ if (b->core.tid != iter->tid || b->core.pos >= iter->end) { // no need to proceed
+ ret = bam_validate1(NULL, b)? -1 : -5; // determine whether end of region or error
+ break;
+ }
+ else if (is_overlap(iter->beg, iter->end, b)) return ret;
+ } else break; // end of file or error
+ }
+ iter->finished = 1;
+ return ret;
+}
+
+int bam_fetch(bamFile fp, const bam_index_t *idx, int tid, int beg, int end, void *data, bam_fetch_f func)
+{
+ int ret;
+ bam_iter_t iter;
+ bam1_t *b;
+ b = bam_init1();
+ iter = bam_iter_query(idx, tid, beg, end);
+ while ((ret = bam_iter_read(fp, iter, b)) >= 0) func(b, data);
+ bam_iter_destroy(iter);
+ bam_destroy1(b);
+ return (ret == -1)? 0 : ret;
+}
+++ /dev/null
-#include <stdlib.h>
-#include <stdio.h>
-#include <assert.h>
-#include "bam.h"
-#include "ksort.h"
-
-#define TV_GAP 2
-
-typedef struct __freenode_t {
- uint32_t level:28, cnt:4;
- struct __freenode_t *next;
-} freenode_t, *freenode_p;
-
-#define freenode_lt(a,b) ((a)->cnt < (b)->cnt || ((a)->cnt == (b)->cnt && (a)->level < (b)->level))
-KSORT_INIT(node, freenode_p, freenode_lt)
-
-/* Memory pool, similar to the one in bam_pileup.c */
-typedef struct {
- int cnt, n, max;
- freenode_t **buf;
-} mempool_t;
-
-static mempool_t *mp_init()
-{
- return (mempool_t*)calloc(1, sizeof(mempool_t));
-}
-static void mp_destroy(mempool_t *mp)
-{
- int k;
- for (k = 0; k < mp->n; ++k) free(mp->buf[k]);
- free(mp->buf); free(mp);
-}
-static inline freenode_t *mp_alloc(mempool_t *mp)
-{
- ++mp->cnt;
- if (mp->n == 0) return (freenode_t*)calloc(1, sizeof(freenode_t));
- else return mp->buf[--mp->n];
-}
-static inline void mp_free(mempool_t *mp, freenode_t *p)
-{
- --mp->cnt; p->next = 0; p->cnt = TV_GAP;
- if (mp->n == mp->max) {
- mp->max = mp->max? mp->max<<1 : 256;
- mp->buf = (freenode_t**)realloc(mp->buf, sizeof(freenode_t*) * mp->max);
- }
- mp->buf[mp->n++] = p;
-}
-
-/* core part */
-struct __bam_lplbuf_t {
- int max, n_cur, n_pre;
- int max_level, *cur_level, *pre_level;
- mempool_t *mp;
- freenode_t **aux, *head, *tail;
- int n_nodes, m_aux;
- bam_pileup_f func;
- void *user_data;
- bam_plbuf_t *plbuf;
-};
-
-void bam_lplbuf_reset(bam_lplbuf_t *buf)
-{
- freenode_t *p, *q;
- bam_plbuf_reset(buf->plbuf);
- for (p = buf->head; p->next;) {
- q = p->next;
- mp_free(buf->mp, p);
- p = q;
- }
- buf->head = buf->tail;
- buf->max_level = 0;
- buf->n_cur = buf->n_pre = 0;
- buf->n_nodes = 0;
-}
-
-static int tview_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pl, void *data)
-{
- bam_lplbuf_t *tv = (bam_lplbuf_t*)data;
- freenode_t *p;
- int i, l, max_level;
- // allocate memory if necessary
- if (tv->max < n) { // enlarge
- tv->max = n;
- kroundup32(tv->max);
- tv->cur_level = (int*)realloc(tv->cur_level, sizeof(int) * tv->max);
- tv->pre_level = (int*)realloc(tv->pre_level, sizeof(int) * tv->max);
- }
- tv->n_cur = n;
- // update cnt
- for (p = tv->head; p->next; p = p->next)
- if (p->cnt > 0) --p->cnt;
- // calculate cur_level[]
- max_level = 0;
- for (i = l = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (p->is_head) {
- if (tv->head->next && tv->head->cnt == 0) { // then take a free slot
- freenode_t *p = tv->head->next;
- tv->cur_level[i] = tv->head->level;
- mp_free(tv->mp, tv->head);
- tv->head = p;
- --tv->n_nodes;
- } else tv->cur_level[i] = ++tv->max_level;
- } else {
- tv->cur_level[i] = tv->pre_level[l++];
- if (p->is_tail) { // then return a free slot
- tv->tail->level = tv->cur_level[i];
- tv->tail->next = mp_alloc(tv->mp);
- tv->tail = tv->tail->next;
- ++tv->n_nodes;
- }
- }
- if (tv->cur_level[i] > max_level) max_level = tv->cur_level[i];
- ((bam_pileup1_t*)p)->level = tv->cur_level[i];
- }
- assert(l == tv->n_pre);
- tv->func(tid, pos, n, pl, tv->user_data);
- // sort the linked list
- if (tv->n_nodes) {
- freenode_t *q;
- if (tv->n_nodes + 1 > tv->m_aux) { // enlarge
- tv->m_aux = tv->n_nodes + 1;
- kroundup32(tv->m_aux);
- tv->aux = (freenode_t**)realloc(tv->aux, sizeof(void*) * tv->m_aux);
- }
- for (p = tv->head, i = l = 0; p->next;) {
- if (p->level > max_level) { // then discard this entry
- q = p->next;
- mp_free(tv->mp, p);
- p = q;
- } else {
- tv->aux[i++] = p;
- p = p->next;
- }
- }
- tv->aux[i] = tv->tail; // add a proper tail for the loop below
- tv->n_nodes = i;
- if (tv->n_nodes) {
- ks_introsort(node, tv->n_nodes, tv->aux);
- for (i = 0; i < tv->n_nodes; ++i) tv->aux[i]->next = tv->aux[i+1];
- tv->head = tv->aux[0];
- } else tv->head = tv->tail;
- }
- // clean up
- tv->max_level = max_level;
- memcpy(tv->pre_level, tv->cur_level, tv->n_cur * 4);
- // squeeze out terminated levels
- for (i = l = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (!p->is_tail)
- tv->pre_level[l++] = tv->pre_level[i];
- }
- tv->n_pre = l;
-/*
- fprintf(stderr, "%d\t", pos+1);
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (p->is_head) fprintf(stderr, "^");
- if (p->is_tail) fprintf(stderr, "$");
- fprintf(stderr, "%d,", p->level);
- }
- fprintf(stderr, "\n");
-*/
- return 0;
-}
-
-bam_lplbuf_t *bam_lplbuf_init(bam_pileup_f func, void *data)
-{
- bam_lplbuf_t *tv;
- tv = (bam_lplbuf_t*)calloc(1, sizeof(bam_lplbuf_t));
- tv->mp = mp_init();
- tv->head = tv->tail = mp_alloc(tv->mp);
- tv->func = func;
- tv->user_data = data;
- tv->plbuf = bam_plbuf_init(tview_func, tv);
- return (bam_lplbuf_t*)tv;
-}
-
-void bam_lplbuf_destroy(bam_lplbuf_t *tv)
-{
- freenode_t *p, *q;
- free(tv->cur_level); free(tv->pre_level);
- bam_plbuf_destroy(tv->plbuf);
- free(tv->aux);
- for (p = tv->head; p->next;) {
- q = p->next;
- mp_free(tv->mp, p); p = q;
- }
- mp_free(tv->mp, p);
- assert(tv->mp->cnt == 0);
- mp_destroy(tv->mp);
- free(tv);
-}
-
-int bam_lplbuf_push(const bam1_t *b, bam_lplbuf_t *tv)
-{
- return bam_plbuf_push(b, tv->plbuf);
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <stdio.h>
+#include <assert.h>
+#include "bam.h"
+#include "ksort.h"
+
+#define TV_GAP 2
+
+typedef struct __freenode_t {
+ uint32_t level:28, cnt:4;
+ struct __freenode_t *next;
+} freenode_t, *freenode_p;
+
+#define freenode_lt(a,b) ((a)->cnt < (b)->cnt || ((a)->cnt == (b)->cnt && (a)->level < (b)->level))
+KSORT_INIT(node, freenode_p, freenode_lt)
+
+/* Memory pool, similar to the one in bam_pileup.c */
+typedef struct {
+ int cnt, n, max;
+ freenode_t **buf;
+} mempool_t;
+
+static mempool_t *mp_init()
+{
+ return (mempool_t*)calloc(1, sizeof(mempool_t));
+}
+static void mp_destroy(mempool_t *mp)
+{
+ int k;
+ for (k = 0; k < mp->n; ++k) free(mp->buf[k]);
+ free(mp->buf); free(mp);
+}
+static inline freenode_t *mp_alloc(mempool_t *mp)
+{
+ ++mp->cnt;
+ if (mp->n == 0) return (freenode_t*)calloc(1, sizeof(freenode_t));
+ else return mp->buf[--mp->n];
+}
+static inline void mp_free(mempool_t *mp, freenode_t *p)
+{
+ --mp->cnt; p->next = 0; p->cnt = TV_GAP;
+ if (mp->n == mp->max) {
+ mp->max = mp->max? mp->max<<1 : 256;
+ mp->buf = (freenode_t**)realloc(mp->buf, sizeof(freenode_t*) * mp->max);
+ }
+ mp->buf[mp->n++] = p;
+}
+
+/* core part */
+struct __bam_lplbuf_t {
+ int max, n_cur, n_pre;
+ int max_level, *cur_level, *pre_level;
+ mempool_t *mp;
+ freenode_t **aux, *head, *tail;
+ int n_nodes, m_aux;
+ bam_pileup_f func;
+ void *user_data;
+ bam_plbuf_t *plbuf;
+};
+
+void bam_lplbuf_reset(bam_lplbuf_t *buf)
+{
+ freenode_t *p, *q;
+ bam_plbuf_reset(buf->plbuf);
+ for (p = buf->head; p->next;) {
+ q = p->next;
+ mp_free(buf->mp, p);
+ p = q;
+ }
+ buf->head = buf->tail;
+ buf->max_level = 0;
+ buf->n_cur = buf->n_pre = 0;
+ buf->n_nodes = 0;
+}
+
+static int tview_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pl, void *data)
+{
+ bam_lplbuf_t *tv = (bam_lplbuf_t*)data;
+ freenode_t *p;
+ int i, l, max_level;
+ // allocate memory if necessary
+ if (tv->max < n) { // enlarge
+ tv->max = n;
+ kroundup32(tv->max);
+ tv->cur_level = (int*)realloc(tv->cur_level, sizeof(int) * tv->max);
+ tv->pre_level = (int*)realloc(tv->pre_level, sizeof(int) * tv->max);
+ }
+ tv->n_cur = n;
+ // update cnt
+ for (p = tv->head; p->next; p = p->next)
+ if (p->cnt > 0) --p->cnt;
+ // calculate cur_level[]
+ max_level = 0;
+ for (i = l = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (p->is_head) {
+ if (tv->head->next && tv->head->cnt == 0) { // then take a free slot
+ freenode_t *p = tv->head->next;
+ tv->cur_level[i] = tv->head->level;
+ mp_free(tv->mp, tv->head);
+ tv->head = p;
+ --tv->n_nodes;
+ } else tv->cur_level[i] = ++tv->max_level;
+ } else {
+ tv->cur_level[i] = tv->pre_level[l++];
+ if (p->is_tail) { // then return a free slot
+ tv->tail->level = tv->cur_level[i];
+ tv->tail->next = mp_alloc(tv->mp);
+ tv->tail = tv->tail->next;
+ ++tv->n_nodes;
+ }
+ }
+ if (tv->cur_level[i] > max_level) max_level = tv->cur_level[i];
+ ((bam_pileup1_t*)p)->level = tv->cur_level[i];
+ }
+ assert(l == tv->n_pre);
+ tv->func(tid, pos, n, pl, tv->user_data);
+ // sort the linked list
+ if (tv->n_nodes) {
+ freenode_t *q;
+ if (tv->n_nodes + 1 > tv->m_aux) { // enlarge
+ tv->m_aux = tv->n_nodes + 1;
+ kroundup32(tv->m_aux);
+ tv->aux = (freenode_t**)realloc(tv->aux, sizeof(void*) * tv->m_aux);
+ }
+ for (p = tv->head, i = l = 0; p->next;) {
+ if (p->level > max_level) { // then discard this entry
+ q = p->next;
+ mp_free(tv->mp, p);
+ p = q;
+ } else {
+ tv->aux[i++] = p;
+ p = p->next;
+ }
+ }
+ tv->aux[i] = tv->tail; // add a proper tail for the loop below
+ tv->n_nodes = i;
+ if (tv->n_nodes) {
+ ks_introsort(node, tv->n_nodes, tv->aux);
+ for (i = 0; i < tv->n_nodes; ++i) tv->aux[i]->next = tv->aux[i+1];
+ tv->head = tv->aux[0];
+ } else tv->head = tv->tail;
+ }
+ // clean up
+ tv->max_level = max_level;
+ memcpy(tv->pre_level, tv->cur_level, tv->n_cur * 4);
+ // squeeze out terminated levels
+ for (i = l = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (!p->is_tail)
+ tv->pre_level[l++] = tv->pre_level[i];
+ }
+ tv->n_pre = l;
+/*
+ fprintf(pysamerr, "%d\t", pos+1);
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (p->is_head) fprintf(pysamerr, "^");
+ if (p->is_tail) fprintf(pysamerr, "$");
+ fprintf(pysamerr, "%d,", p->level);
+ }
+ fprintf(pysamerr, "\n");
+*/
+ return 0;
+}
+
+bam_lplbuf_t *bam_lplbuf_init(bam_pileup_f func, void *data)
+{
+ bam_lplbuf_t *tv;
+ tv = (bam_lplbuf_t*)calloc(1, sizeof(bam_lplbuf_t));
+ tv->mp = mp_init();
+ tv->head = tv->tail = mp_alloc(tv->mp);
+ tv->func = func;
+ tv->user_data = data;
+ tv->plbuf = bam_plbuf_init(tview_func, tv);
+ return (bam_lplbuf_t*)tv;
+}
+
+void bam_lplbuf_destroy(bam_lplbuf_t *tv)
+{
+ freenode_t *p, *q;
+ free(tv->cur_level); free(tv->pre_level);
+ bam_plbuf_destroy(tv->plbuf);
+ free(tv->aux);
+ for (p = tv->head; p->next;) {
+ q = p->next;
+ mp_free(tv->mp, p); p = q;
+ }
+ mp_free(tv->mp, p);
+ assert(tv->mp->cnt == 0);
+ mp_destroy(tv->mp);
+ free(tv);
+}
+
+int bam_lplbuf_push(const bam1_t *b, bam_lplbuf_t *tv)
+{
+ return bam_plbuf_push(b, tv->plbuf);
+}
+++ /dev/null
-#include <math.h>
-#include <assert.h>
-#include "bam.h"
-#include "bam_maqcns.h"
-#include "ksort.h"
-#include "kaln.h"
-KSORT_INIT_GENERIC(uint32_t)
-
-#define INDEL_WINDOW_SIZE 50
-#define INDEL_EXT_DEP 0.9
-
-typedef struct __bmc_aux_t {
- int max;
- uint32_t *info;
-} bmc_aux_t;
-
-typedef struct {
- float esum[4], fsum[4];
- uint32_t c[4];
- uint32_t rms_mapQ;
-} glf_call_aux_t;
-
-char bam_nt16_nt4_table[] = { 4, 0, 1, 4, 2, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4 };
-
-/*
- P(<b1,b2>) = \theta \sum_{i=1}^{N-1} 1/i
- P(D|<b1,b2>) = \sum_{k=1}^{N-1} p_k 1/2 [(k/N)^n_2(1-k/N)^n_1 + (k/N)^n1(1-k/N)^n_2]
- p_k = 1/k / \sum_{i=1}^{N-1} 1/i
- */
-static void cal_het(bam_maqcns_t *aa)
-{
- int k, n1, n2;
- double sum_harmo; // harmonic sum
- double poly_rate;
-
- free(aa->lhet);
- aa->lhet = (double*)calloc(256 * 256, sizeof(double));
- sum_harmo = 0.0;
- for (k = 1; k <= aa->n_hap - 1; ++k)
- sum_harmo += 1.0 / k;
- for (n1 = 0; n1 < 256; ++n1) {
- for (n2 = 0; n2 < 256; ++n2) {
- long double sum = 0.0;
- double lC = aa->is_soap? 0 : lgamma(n1+n2+1) - lgamma(n1+1) - lgamma(n2+1); // \binom{n1+n2}{n1}
- for (k = 1; k <= aa->n_hap - 1; ++k) {
- double pk = 1.0 / k / sum_harmo;
- double log1 = log((double)k/aa->n_hap);
- double log2 = log(1.0 - (double)k/aa->n_hap);
- sum += pk * 0.5 * (expl(log1*n2) * expl(log2*n1) + expl(log1*n1) * expl(log2*n2));
- }
- aa->lhet[n1<<8|n2] = lC + logl(sum);
- }
- }
- poly_rate = aa->het_rate * sum_harmo;
- aa->q_r = -4.343 * log(2.0 * poly_rate / (1.0 - poly_rate));
-}
-
-/** initialize the helper structure */
-static void cal_coef(bam_maqcns_t *aa)
-{
- int k, n, q;
- long double sum_a[257], b[256], q_c[256], tmp[256], fk2[256];
- double *lC;
-
- // aa->lhet will be allocated and initialized
- free(aa->fk); free(aa->coef);
- aa->coef = 0;
- aa->fk = (double*)calloc(256, sizeof(double));
- aa->fk[0] = fk2[0] = 1.0;
- for (n = 1; n != 256; ++n) {
- aa->fk[n] = pow(aa->theta, n) * (1.0 - aa->eta) + aa->eta;
- fk2[n] = aa->fk[n>>1]; // this is an approximation, assuming reads equally likely come from both strands
- }
- if (aa->is_soap) return;
- aa->coef = (double*)calloc(256*256*64, sizeof(double));
- lC = (double*)calloc(256 * 256, sizeof(double));
- for (n = 1; n != 256; ++n)
- for (k = 1; k <= n; ++k)
- lC[n<<8|k] = lgamma(n+1) - lgamma(k+1) - lgamma(n-k+1);
- for (q = 1; q != 64; ++q) {
- double e = pow(10.0, -q/10.0);
- double le = log(e);
- double le1 = log(1.0-e);
- for (n = 1; n != 256; ++n) {
- double *coef = aa->coef + (q<<16|n<<8);
- sum_a[n+1] = 0.0;
- for (k = n; k >= 0; --k) { // a_k = \sum_{i=k}^n C^n_k \epsilon^k (1-\epsilon)^{n-k}
- sum_a[k] = sum_a[k+1] + expl(lC[n<<8|k] + k*le + (n-k)*le1);
- b[k] = sum_a[k+1] / sum_a[k];
- if (b[k] > 0.99) b[k] = 0.99;
- }
- for (k = 0; k != n; ++k) // log(\bar\beta_{nk}(\bar\epsilon)^{f_k})
- q_c[k] = -4.343 * fk2[k] * logl(b[k] / e);
- for (k = 1; k != n; ++k) q_c[k] += q_c[k-1]; // \prod_{i=0}^k c_i
- for (k = 0; k <= n; ++k) { // powl() in 64-bit mode seems broken on my Mac OS X 10.4.9
- tmp[k] = -4.343 * logl(1.0 - expl(fk2[k] * logl(b[k])));
- coef[k] = (k? q_c[k-1] : 0) + tmp[k]; // this is the final c_{nk}
- }
- }
- }
- free(lC);
-}
-
-bam_maqcns_t *bam_maqcns_init()
-{
- bam_maqcns_t *bm;
- bm = (bam_maqcns_t*)calloc(1, sizeof(bam_maqcns_t));
- bm->aux = (bmc_aux_t*)calloc(1, sizeof(bmc_aux_t));
- bm->het_rate = 0.001;
- bm->theta = 0.85;
- bm->n_hap = 2;
- bm->eta = 0.03;
- bm->cap_mapQ = 60;
- return bm;
-}
-
-void bam_maqcns_prepare(bam_maqcns_t *bm)
-{
- cal_coef(bm); cal_het(bm);
-}
-
-void bam_maqcns_destroy(bam_maqcns_t *bm)
-{
- if (bm == 0) return;
- free(bm->lhet); free(bm->fk); free(bm->coef); free(bm->aux->info);
- free(bm->aux); free(bm);
-}
-
-glf1_t *bam_maqcns_glfgen(int _n, const bam_pileup1_t *pl, uint8_t ref_base, bam_maqcns_t *bm)
-{
- glf_call_aux_t *b;
- int i, j, k, w[8], c, n;
- glf1_t *g = (glf1_t*)calloc(1, sizeof(glf1_t));
- float p[16], min_p = 1e30;
- uint64_t rms;
-
- g->ref_base = ref_base;
- if (_n == 0) return g;
-
- // construct aux array
- if (bm->aux->max < _n) {
- bm->aux->max = _n;
- kroundup32(bm->aux->max);
- bm->aux->info = (uint32_t*)realloc(bm->aux->info, 4 * bm->aux->max);
- }
- for (i = n = 0; i < _n; ++i) {
- const bam_pileup1_t *p = pl + i;
- uint32_t q, x = 0, qq;
- if (p->is_del || (p->b->core.flag&BAM_FUNMAP)) continue;
- q = (uint32_t)bam1_qual(p->b)[p->qpos];
- x |= (uint32_t)bam1_strand(p->b) << 18 | q << 8 | p->b->core.qual;
- if (p->b->core.qual < q) q = p->b->core.qual;
- x |= q << 24;
- qq = bam1_seqi(bam1_seq(p->b), p->qpos);
- q = bam_nt16_nt4_table[qq? qq : ref_base];
- if (!p->is_del && q < 4) x |= 1 << 21 | q << 16;
- bm->aux->info[n++] = x;
- }
- ks_introsort(uint32_t, n, bm->aux->info);
- // generate esum and fsum
- b = (glf_call_aux_t*)calloc(1, sizeof(glf_call_aux_t));
- for (k = 0; k != 8; ++k) w[k] = 0;
- rms = 0;
- for (j = n - 1; j >= 0; --j) { // calculate esum and fsum
- uint32_t info = bm->aux->info[j];
- int tmp;
- if (info>>24 < 4 && (info>>8&0x3f) != 0) info = 4<<24 | (info&0xffffff);
- k = info>>16&7;
- if (info>>24 > 0) {
- b->esum[k&3] += bm->fk[w[k]] * (info>>24);
- b->fsum[k&3] += bm->fk[w[k]];
- if (w[k] < 0xff) ++w[k];
- ++b->c[k&3];
- }
- tmp = (int)(info&0xff) < bm->cap_mapQ? (int)(info&0xff) : bm->cap_mapQ;
- rms += tmp * tmp;
- }
- b->rms_mapQ = (uint8_t)(sqrt((double)rms / n) + .499);
- // rescale ->c[]
- for (j = c = 0; j != 4; ++j) c += b->c[j];
- if (c > 255) {
- for (j = 0; j != 4; ++j) b->c[j] = (int)(254.0 * b->c[j] / c + 0.5);
- for (j = c = 0; j != 4; ++j) c += b->c[j];
- }
- if (!bm->is_soap) {
- // generate likelihood
- for (j = 0; j != 4; ++j) {
- // homozygous
- float tmp1, tmp3;
- int tmp2, bar_e;
- for (k = 0, tmp1 = tmp3 = 0.0, tmp2 = 0; k != 4; ++k) {
- if (j == k) continue;
- tmp1 += b->esum[k]; tmp2 += b->c[k]; tmp3 += b->fsum[k];
- }
- if (tmp2) {
- bar_e = (int)(tmp1 / tmp3 + 0.5);
- if (bar_e < 4) bar_e = 4; // should not happen
- if (bar_e > 63) bar_e = 63;
- p[j<<2|j] = tmp1 + bm->coef[bar_e<<16|c<<8|tmp2];
- } else p[j<<2|j] = 0.0; // all the bases are j
- // heterozygous
- for (k = j + 1; k < 4; ++k) {
- for (i = 0, tmp2 = 0, tmp1 = tmp3 = 0.0; i != 4; ++i) {
- if (i == j || i == k) continue;
- tmp1 += b->esum[i]; tmp2 += b->c[i]; tmp3 += b->fsum[i];
- }
- if (tmp2) {
- bar_e = (int)(tmp1 / tmp3 + 0.5);
- if (bar_e < 4) bar_e = 4;
- if (bar_e > 63) bar_e = 63;
- p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]] + tmp1 + bm->coef[bar_e<<16|c<<8|tmp2];
- } else p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]]; // all the bases are either j or k
- }
- //
- for (k = 0; k != 4; ++k)
- if (p[j<<2|k] < 0.0) p[j<<2|k] = 0.0;
- }
-
- { // fix p[k<<2|k]
- float max1, max2, min1, min2;
- int max_k, min_k;
- max_k = min_k = -1;
- max1 = max2 = -1.0; min1 = min2 = 1e30;
- for (k = 0; k < 4; ++k) {
- if (b->esum[k] > max1) {
- max2 = max1; max1 = b->esum[k]; max_k = k;
- } else if (b->esum[k] > max2) max2 = b->esum[k];
- }
- for (k = 0; k < 4; ++k) {
- if (p[k<<2|k] < min1) {
- min2 = min1; min1 = p[k<<2|k]; min_k = k;
- } else if (p[k<<2|k] < min2) min2 = p[k<<2|k];
- }
- if (max1 > max2 && (min_k != max_k || min1 + 1.0 > min2))
- p[max_k<<2|max_k] = min1 > 1.0? min1 - 1.0 : 0.0;
- }
- } else { // apply the SOAP model
- // generate likelihood
- for (j = 0; j != 4; ++j) {
- float tmp;
- // homozygous
- for (k = 0, tmp = 0.0; k != 4; ++k)
- if (j != k) tmp += b->esum[k];
- p[j<<2|j] = tmp;
- // heterozygous
- for (k = j + 1; k < 4; ++k) {
- for (i = 0, tmp = 0.0; i != 4; ++i)
- if (i != j && i != k) tmp += b->esum[i];
- p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]] + tmp;
- }
- }
- }
-
- // convert necessary information to glf1_t
- g->ref_base = ref_base; g->max_mapQ = b->rms_mapQ;
- g->depth = n > 16777215? 16777215 : n;
- for (j = 0; j != 4; ++j)
- for (k = j; k < 4; ++k)
- if (p[j<<2|k] < min_p) min_p = p[j<<2|k];
- g->min_lk = min_p > 255.0? 255 : (int)(min_p + 0.5);
- for (j = c = 0; j != 4; ++j)
- for (k = j; k < 4; ++k)
- g->lk[c++] = p[j<<2|k]-min_p > 255.0? 255 : (int)(p[j<<2|k]-min_p + 0.5);
-
- free(b);
- return g;
-}
-
-uint32_t glf2cns(const glf1_t *g, int q_r)
-{
- int i, j, k, tmp[16], min = 10000, min2 = 10000, min3 = 10000, min_g = -1, min_g2 = -1;
- uint32_t x = 0;
- for (i = k = 0; i < 4; ++i)
- for (j = i; j < 4; ++j) {
- tmp[j<<2|i] = -1;
- tmp[i<<2|j] = g->lk[k++] + (i == j? 0 : q_r);
- }
- for (i = 0; i < 16; ++i) {
- if (tmp[i] < 0) continue;
- if (tmp[i] < min) {
- min3 = min2; min2 = min; min = tmp[i]; min_g2 = min_g; min_g = i;
- } else if (tmp[i] < min2) {
- min3 = min2; min2 = tmp[i]; min_g2 = i;
- } else if (tmp[i] < min3) min3 = tmp[i];
- }
- x = min_g >= 0? (1U<<(min_g>>2&3) | 1U<<(min_g&3)) << 28 : 0xf << 28;
- x |= min_g2 >= 0? (1U<<(min_g2>>2&3) | 1U<<(min_g2&3)) << 24 : 0xf << 24;
- x |= (uint32_t)g->max_mapQ << 16;
- x |= min2 < 10000? (min2 - min < 256? min2 - min : 255) << 8 : 0xff << 8;
- x |= min2 < 10000 && min3 < 10000? (min3 - min2 < 256? min3 - min2 : 255) : 0xff;
- return x;
-}
-
-uint32_t bam_maqcns_call(int n, const bam_pileup1_t *pl, bam_maqcns_t *bm)
-{
- glf1_t *g;
- uint32_t x;
- if (n) {
- g = bam_maqcns_glfgen(n, pl, 0xf, bm);
- x = glf2cns(g, (int)(bm->q_r + 0.5));
- free(g);
- } else x = 0xfU<<28 | 0xfU<<24;
- return x;
-}
-
-/************** *****************/
-
-bam_maqindel_opt_t *bam_maqindel_opt_init()
-{
- bam_maqindel_opt_t *mi = (bam_maqindel_opt_t*)calloc(1, sizeof(bam_maqindel_opt_t));
- mi->q_indel = 40;
- mi->r_indel = 0.00015;
- mi->r_snp = 0.001;
- //
- mi->mm_penalty = 3;
- mi->indel_err = 4;
- mi->ambi_thres = 10;
- return mi;
-}
-
-void bam_maqindel_ret_destroy(bam_maqindel_ret_t *mir)
-{
- if (mir == 0) return;
- free(mir->s[0]); free(mir->s[1]); free(mir);
-}
-
-int bam_tpos2qpos(const bam1_core_t *c, const uint32_t *cigar, int32_t tpos, int is_left, int32_t *_tpos)
-{
- int k, x = c->pos, y = 0, last_y = 0;
- *_tpos = c->pos;
- for (k = 0; k < c->n_cigar; ++k) {
- int op = cigar[k] & BAM_CIGAR_MASK;
- int l = cigar[k] >> BAM_CIGAR_SHIFT;
- if (op == BAM_CMATCH) {
- if (c->pos > tpos) return y;
- if (x + l > tpos) {
- *_tpos = tpos;
- return y + (tpos - x);
- }
- x += l; y += l;
- last_y = y;
- } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
- else if (op == BAM_CDEL || op == BAM_CREF_SKIP) {
- if (x + l > tpos) {
- *_tpos = is_left? x : x + l;
- return y;
- }
- x += l;
- }
- }
- *_tpos = x;
- return last_y;
-}
-
-#define MINUS_CONST 0x10000000
-
-bam_maqindel_ret_t *bam_maqindel(int n, int pos, const bam_maqindel_opt_t *mi, const bam_pileup1_t *pl, const char *ref,
- int _n_types, int *_types)
-{
- int i, j, n_types, *types, left, right, max_rd_len = 0;
- bam_maqindel_ret_t *ret = 0;
- // if there is no proposed indel, check if there is an indel from the alignment
- if (_n_types == 0) {
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (!(p->b->core.flag&BAM_FUNMAP) && p->indel != 0) break;
- }
- if (i == n) return 0; // no indel
- }
- { // calculate how many types of indels are available (set n_types and types)
- int m;
- uint32_t *aux;
- aux = (uint32_t*)calloc(n + _n_types + 1, 4);
- m = 0;
- aux[m++] = MINUS_CONST; // zero indel is always a type
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (!(p->b->core.flag&BAM_FUNMAP) && p->indel != 0)
- aux[m++] = MINUS_CONST + p->indel;
- j = bam_cigar2qlen(&p->b->core, bam1_cigar(p->b));
- if (j > max_rd_len) max_rd_len = j;
- }
- if (_n_types) // then also add this to aux[]
- for (i = 0; i < _n_types; ++i)
- if (_types[i]) aux[m++] = MINUS_CONST + _types[i];
- ks_introsort(uint32_t, m, aux);
- // squeeze out identical types
- for (i = 1, n_types = 1; i < m; ++i)
- if (aux[i] != aux[i-1]) ++n_types;
- types = (int*)calloc(n_types, sizeof(int));
- j = 0;
- types[j++] = aux[0] - MINUS_CONST;
- for (i = 1; i < m; ++i) {
- if (aux[i] != aux[i-1])
- types[j++] = aux[i] - MINUS_CONST;
- }
- free(aux);
- }
- { // calculate left and right boundary
- left = pos > INDEL_WINDOW_SIZE? pos - INDEL_WINDOW_SIZE : 0;
- right = pos + INDEL_WINDOW_SIZE;
- if (types[0] < 0) right -= types[0];
- // in case the alignments stand out the reference
- for (i = pos; i < right; ++i)
- if (ref[i] == 0) break;
- right = i;
- }
- { // the core part
- char *ref2, *rs, *inscns = 0;
- int qr_snp, k, l, *score, *pscore, max_ins = types[n_types-1];
- qr_snp = (int)(-4.343 * log(mi->r_snp) + .499);
- if (max_ins > 0) { // get the consensus of inserted sequences
- int *inscns_aux = (int*)calloc(4 * n_types * max_ins, sizeof(int));
- // count occurrences
- for (i = 0; i < n_types; ++i) {
- if (types[i] <= 0) continue; // not insertion
- for (j = 0; j < n; ++j) {
- const bam_pileup1_t *p = pl + j;
- if (!(p->b->core.flag&BAM_FUNMAP) && p->indel == types[i]) {
- for (k = 1; k <= p->indel; ++k) {
- int c = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos + k)];
- if (c < 4) ++inscns_aux[i*max_ins*4 + (k-1)*4 + c];
- }
- }
- }
- }
- // construct the consensus of inserted sequence
- inscns = (char*)calloc(n_types * max_ins, sizeof(char));
- for (i = 0; i < n_types; ++i) {
- for (j = 0; j < types[i]; ++j) {
- int max = 0, max_k = -1, *ia = inscns_aux + i*max_ins*4 + j*4;
- for (k = 0; k < 4; ++k) {
- if (ia[k] > max) {
- max = ia[k];
- max_k = k;
- }
- }
- inscns[i*max_ins + j] = max? 1<<max_k : 15;
- }
- }
- free(inscns_aux);
- }
- // calculate score
- ref2 = (char*)calloc(right - left + types[n_types-1] + 2, 1);
- rs = (char*)calloc(right - left + max_rd_len + types[n_types-1] + 2, 1);
- score = (int*)calloc(n_types * n, sizeof(int));
- pscore = (int*)calloc(n_types * n, sizeof(int));
- for (i = 0; i < n_types; ++i) {
- ka_param_t ap = ka_param_blast;
- ap.band_width = 2 * types[n_types - 1] + 2;
- ap.gap_end = 0;
- // write ref2
- for (k = 0, j = left; j <= pos; ++j)
- ref2[k++] = bam_nt16_nt4_table[bam_nt16_table[(int)ref[j]]];
- if (types[i] <= 0) j += -types[i];
- else for (l = 0; l < types[i]; ++l)
- ref2[k++] = bam_nt16_nt4_table[(int)inscns[i*max_ins + l]];
- if (types[0] < 0) { // mask deleted sequences
- int jj, tmp = types[i] >= 0? -types[0] : -types[0] + types[i];
- for (jj = 0; jj < tmp && j < right && ref[j]; ++jj, ++j)
- ref2[k++] = 4;
- }
- for (; j < right && ref[j]; ++j)
- ref2[k++] = bam_nt16_nt4_table[bam_nt16_table[(int)ref[j]]];
- if (j < right) right = j;
- // calculate score for each read
- for (j = 0; j < n; ++j) {
- const bam_pileup1_t *p = pl + j;
- int qbeg, qend, tbeg, tend;
- if (p->b->core.flag & BAM_FUNMAP) continue;
- qbeg = bam_tpos2qpos(&p->b->core, bam1_cigar(p->b), left, 0, &tbeg);
- qend = bam_tpos2qpos(&p->b->core, bam1_cigar(p->b), right, 1, &tend);
- assert(tbeg >= left);
- for (l = qbeg; l < qend; ++l)
- rs[l - qbeg] = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), l)];
- {
- int x, y, n_acigar, ps;
- uint32_t *acigar;
- ps = 0;
- if (tend - tbeg + types[i] <= 0) {
- score[i*n+j] = -(1<<20);
- pscore[i*n+j] = 1<<20;
- continue;
- }
- acigar = ka_global_core((uint8_t*)ref2 + tbeg - left, tend - tbeg + types[i], (uint8_t*)rs, qend - qbeg, &ap, &score[i*n+j], &n_acigar);
- x = tbeg - left; y = 0;
- for (l = 0; l < n_acigar; ++l) {
- int op = acigar[l]&0xf;
- int len = acigar[l]>>4;
- if (op == BAM_CMATCH) {
- int k;
- for (k = 0; k < len; ++k)
- if (ref2[x+k] != rs[y+k] && ref2[x+k] < 4)
- ps += bam1_qual(p->b)[y+k] < qr_snp? bam1_qual(p->b)[y+k] : qr_snp;
- x += len; y += len;
- } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) {
- if (op == BAM_CINS && l > 0 && l < n_acigar - 1) ps += mi->q_indel * len;
- y += len;
- } else if (op == BAM_CDEL) {
- if (l > 0 && l < n_acigar - 1) ps += mi->q_indel * len;
- x += len;
- }
- }
- pscore[i*n+j] = ps;
- /*if (1) { // for debugging only
- fprintf(stderr, "id=%d, pos=%d, type=%d, j=%d, score=%d, psore=%d, %d, %d, %d, %d, %d, ",
- j, pos+1, types[i], j, score[i*n+j], pscore[i*n+j], tbeg, tend, qbeg, qend, mi->q_indel);
- for (l = 0; l < n_acigar; ++l) fprintf(stderr, "%d%c", acigar[l]>>4, "MIDS"[acigar[l]&0xf]);
- fprintf(stderr, "\n");
- for (l = 0; l < tend - tbeg + types[i]; ++l) fputc("ACGTN"[ref2[l+tbeg-left]], stderr);
- fputc('\n', stderr);
- for (l = 0; l < qend - qbeg; ++l) fputc("ACGTN"[rs[l]], stderr);
- fputc('\n', stderr);
- }*/
- free(acigar);
- }
- }
- }
- { // get final result
- int *sum, max1, max2, max1_i, max2_i;
- // pick up the best two score
- sum = (int*)calloc(n_types, sizeof(int));
- for (i = 0; i < n_types; ++i)
- for (j = 0; j < n; ++j)
- sum[i] += -pscore[i*n+j];
- max1 = max2 = -0x7fffffff; max1_i = max2_i = -1;
- for (i = 0; i < n_types; ++i) {
- if (sum[i] > max1) {
- max2 = max1; max2_i = max1_i; max1 = sum[i]; max1_i = i;
- } else if (sum[i] > max2) {
- max2 = sum[i]; max2_i = i;
- }
- }
- free(sum);
- // write ret
- ret = (bam_maqindel_ret_t*)calloc(1, sizeof(bam_maqindel_ret_t));
- ret->indel1 = types[max1_i]; ret->indel2 = types[max2_i];
- ret->s[0] = (char*)calloc(abs(ret->indel1) + 2, 1);
- ret->s[1] = (char*)calloc(abs(ret->indel2) + 2, 1);
- // write indel sequence
- if (ret->indel1 > 0) {
- ret->s[0][0] = '+';
- for (k = 0; k < ret->indel1; ++k)
- ret->s[0][k+1] = bam_nt16_rev_table[(int)inscns[max1_i*max_ins + k]];
- } else if (ret->indel1 < 0) {
- ret->s[0][0] = '-';
- for (k = 0; k < -ret->indel1 && ref[pos + k + 1]; ++k)
- ret->s[0][k+1] = ref[pos + k + 1];
- } else ret->s[0][0] = '*';
- if (ret->indel2 > 0) {
- ret->s[1][0] = '+';
- for (k = 0; k < ret->indel2; ++k)
- ret->s[1][k+1] = bam_nt16_rev_table[(int)inscns[max2_i*max_ins + k]];
- } else if (ret->indel2 < 0) {
- ret->s[1][0] = '-';
- for (k = 0; k < -ret->indel2 && ref[pos + k + 1]; ++k)
- ret->s[1][k+1] = ref[pos + k + 1];
- } else ret->s[1][0] = '*';
- // write count
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (p->indel == ret->indel1) ++ret->cnt1;
- else if (p->indel == ret->indel2) ++ret->cnt2;
- else ++ret->cnt_anti;
- }
- { // write gl[]
- int tmp, seq_err = 0;
- double x = 1.0;
- tmp = max1_i - max2_i;
- if (tmp < 0) tmp = -tmp;
- for (j = 0; j < tmp + 1; ++j) x *= INDEL_EXT_DEP;
- seq_err = mi->q_indel * (1.0 - x) / (1.0 - INDEL_EXT_DEP);
- ret->gl[0] = ret->gl[1] = 0;
- for (j = 0; j < n; ++j) {
- int s1 = pscore[max1_i*n + j], s2 = pscore[max2_i*n + j];
- //fprintf(stderr, "id=%d, %d, %d, %d, %d, %d\n", j, pl[j].b->core.pos+1, types[max1_i], types[max2_i], s1, s2);
- if (s1 > s2) ret->gl[0] += s1 - s2 < seq_err? s1 - s2 : seq_err;
- else ret->gl[1] += s2 - s1 < seq_err? s2 - s1 : seq_err;
- }
- }
- // write cnt_ref and cnt_ambi
- if (max1_i != 0 && max2_i != 0) {
- for (j = 0; j < n; ++j) {
- int diff1 = score[j] - score[max1_i * n + j];
- int diff2 = score[j] - score[max2_i * n + j];
- if (diff1 > 0 && diff2 > 0) ++ret->cnt_ref;
- else if (diff1 == 0 || diff2 == 0) ++ret->cnt_ambi;
- }
- }
- }
- free(score); free(pscore); free(ref2); free(rs); free(inscns);
- }
- { // call genotype
- int q[3], qr_indel = (int)(-4.343 * log(mi->r_indel) + 0.5);
- int min1, min2, min1_i;
- q[0] = ret->gl[0] + (ret->s[0][0] != '*'? 0 : 0) * qr_indel;
- q[1] = ret->gl[1] + (ret->s[1][0] != '*'? 0 : 0) * qr_indel;
- q[2] = n * 3 + (ret->s[0][0] == '*' || ret->s[1][0] == '*'? 1 : 1) * qr_indel;
- min1 = min2 = 0x7fffffff; min1_i = -1;
- for (i = 0; i < 3; ++i) {
- if (q[i] < min1) {
- min2 = min1; min1 = q[i]; min1_i = i;
- } else if (q[i] < min2) min2 = q[i];
- }
- ret->gt = min1_i;
- ret->q_cns = min2 - min1;
- // set q_ref
- if (ret->gt < 2) ret->q_ref = (ret->s[ret->gt][0] == '*')? 0 : q[1-ret->gt] - q[ret->gt] - qr_indel - 3;
- else ret->q_ref = (ret->s[0][0] == '*')? q[0] - q[2] : q[1] - q[2];
- if (ret->q_ref < 0) ret->q_ref = 0;
- }
- free(types);
- return ret;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include <assert.h>
+#include "bam.h"
+#include "bam_maqcns.h"
+#include "ksort.h"
+#include "errmod.h"
+#include "kaln.h"
+KSORT_INIT_GENERIC(uint32_t)
+
+#define INDEL_WINDOW_SIZE 50
+#define INDEL_EXT_DEP 0.9
+
+typedef struct __bmc_aux_t {
+ int max;
+ uint32_t *info;
+ uint16_t *info16;
+ errmod_t *em;
+} bmc_aux_t;
+
+typedef struct {
+ float esum[4], fsum[4];
+ uint32_t c[4];
+} glf_call_aux_t;
+
+/*
+ P(<b1,b2>) = \theta \sum_{i=1}^{N-1} 1/i
+ P(D|<b1,b2>) = \sum_{k=1}^{N-1} p_k 1/2 [(k/N)^n_2(1-k/N)^n_1 + (k/N)^n1(1-k/N)^n_2]
+ p_k = 1/k / \sum_{i=1}^{N-1} 1/i
+ */
+static void cal_het(bam_maqcns_t *aa)
+{
+ int k, n1, n2;
+ double sum_harmo; // harmonic sum
+ double poly_rate;
+
+ free(aa->lhet);
+ aa->lhet = (double*)calloc(256 * 256, sizeof(double));
+ sum_harmo = 0.0;
+ for (k = 1; k <= aa->n_hap - 1; ++k)
+ sum_harmo += 1.0 / k;
+ for (n1 = 0; n1 < 256; ++n1) {
+ for (n2 = 0; n2 < 256; ++n2) {
+ long double sum = 0.0;
+ double lC = aa->errmod == BAM_ERRMOD_SOAP? 0 : lgamma(n1+n2+1) - lgamma(n1+1) - lgamma(n2+1);
+ for (k = 1; k <= aa->n_hap - 1; ++k) {
+ double pk = 1.0 / k / sum_harmo;
+ double log1 = log((double)k/aa->n_hap);
+ double log2 = log(1.0 - (double)k/aa->n_hap);
+ sum += pk * 0.5 * (expl(log1*n2) * expl(log2*n1) + expl(log1*n1) * expl(log2*n2));
+ }
+ aa->lhet[n1<<8|n2] = lC + logl(sum);
+ }
+ }
+ poly_rate = aa->het_rate * sum_harmo;
+ aa->q_r = -4.343 * log(2.0 * poly_rate / (1.0 - poly_rate));
+}
+
+/** initialize the helper structure */
+static void cal_coef(bam_maqcns_t *aa)
+{
+ int k, n, q;
+ long double sum_a[257], b[256], q_c[256], tmp[256], fk2[256];
+ double *lC;
+
+ if (aa->errmod == BAM_ERRMOD_MAQ2) return; // no need to do the following
+ // aa->lhet will be allocated and initialized
+ free(aa->fk); free(aa->coef);
+ aa->coef = 0;
+ aa->fk = (double*)calloc(256, sizeof(double));
+ aa->fk[0] = fk2[0] = 1.0;
+ for (n = 1; n != 256; ++n) {
+ aa->fk[n] = pow(aa->theta, n) * (1.0 - aa->eta) + aa->eta;
+ fk2[n] = aa->fk[n>>1]; // this is an approximation, assuming reads equally likely come from both strands
+ }
+ if (aa->errmod == BAM_ERRMOD_SOAP) return;
+ aa->coef = (double*)calloc(256*256*64, sizeof(double));
+ lC = (double*)calloc(256 * 256, sizeof(double));
+ for (n = 1; n != 256; ++n)
+ for (k = 1; k <= n; ++k)
+ lC[n<<8|k] = lgamma(n+1) - lgamma(k+1) - lgamma(n-k+1);
+ for (q = 1; q != 64; ++q) {
+ double e = pow(10.0, -q/10.0);
+ double le = log(e);
+ double le1 = log(1.0-e);
+ for (n = 1; n != 256; ++n) {
+ double *coef = aa->coef + (q<<16|n<<8);
+ sum_a[n+1] = 0.0;
+ for (k = n; k >= 0; --k) { // a_k = \sum_{i=k}^n C^n_k \epsilon^k (1-\epsilon)^{n-k}
+ sum_a[k] = sum_a[k+1] + expl(lC[n<<8|k] + k*le + (n-k)*le1);
+ b[k] = sum_a[k+1] / sum_a[k];
+ if (b[k] > 0.99) b[k] = 0.99;
+ }
+ for (k = 0; k != n; ++k) // log(\bar\beta_{nk}(\bar\epsilon)^{f_k})
+ q_c[k] = -4.343 * fk2[k] * logl(b[k] / e);
+ for (k = 1; k != n; ++k) q_c[k] += q_c[k-1]; // \prod_{i=0}^k c_i
+ for (k = 0; k <= n; ++k) { // powl() in 64-bit mode seems broken on my Mac OS X 10.4.9
+ tmp[k] = -4.343 * logl(1.0 - expl(fk2[k] * logl(b[k])));
+ coef[k] = (k? q_c[k-1] : 0) + tmp[k]; // this is the final c_{nk}
+ }
+ }
+ }
+ free(lC);
+}
+
+bam_maqcns_t *bam_maqcns_init()
+{
+ bam_maqcns_t *bm;
+ bm = (bam_maqcns_t*)calloc(1, sizeof(bam_maqcns_t));
+ bm->aux = (bmc_aux_t*)calloc(1, sizeof(bmc_aux_t));
+ bm->het_rate = 0.001;
+ bm->theta = 0.83f;
+ bm->n_hap = 2;
+ bm->eta = 0.03;
+ bm->cap_mapQ = 60;
+ bm->min_baseQ = 13;
+ return bm;
+}
+
+void bam_maqcns_prepare(bam_maqcns_t *bm)
+{
+ if (bm->errmod == BAM_ERRMOD_MAQ2) bm->aux->em = errmod_init(1. - bm->theta);
+ cal_coef(bm); cal_het(bm);
+}
+
+void bam_maqcns_destroy(bam_maqcns_t *bm)
+{
+ if (bm == 0) return;
+ free(bm->lhet); free(bm->fk); free(bm->coef); free(bm->aux->info); free(bm->aux->info16);
+ if (bm->aux->em) errmod_destroy(bm->aux->em);
+ free(bm->aux); free(bm);
+}
+
+glf1_t *bam_maqcns_glfgen(int _n, const bam_pileup1_t *pl, uint8_t ref_base, bam_maqcns_t *bm)
+{
+ glf_call_aux_t *b = 0;
+ int i, j, k, w[8], c, n;
+ glf1_t *g = (glf1_t*)calloc(1, sizeof(glf1_t));
+ float p[16], min_p = 1e30;
+ uint64_t rms;
+
+ g->ref_base = ref_base;
+ if (_n == 0) return g;
+
+ // construct aux array
+ if (bm->aux->max < _n) {
+ bm->aux->max = _n;
+ kroundup32(bm->aux->max);
+ bm->aux->info = (uint32_t*)realloc(bm->aux->info, 4 * bm->aux->max);
+ bm->aux->info16 = (uint16_t*)realloc(bm->aux->info16, 2 * bm->aux->max);
+ }
+ for (i = n = 0, rms = 0; i < _n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ uint32_t q, x = 0, qq;
+ uint16_t y = 0;
+ if (p->is_del || p->is_refskip || (p->b->core.flag&BAM_FUNMAP)) continue;
+ q = (uint32_t)bam1_qual(p->b)[p->qpos];
+ if (q < bm->min_baseQ) continue;
+ x |= (uint32_t)bam1_strand(p->b) << 18 | q << 8 | p->b->core.qual;
+ y |= bam1_strand(p->b)<<4;
+ if (p->b->core.qual < q) q = p->b->core.qual;
+ c = p->b->core.qual < bm->cap_mapQ? p->b->core.qual : bm->cap_mapQ;
+ rms += c * c;
+ x |= q << 24;
+ y |= q << 5;
+ qq = bam1_seqi(bam1_seq(p->b), p->qpos);
+ q = bam_nt16_nt4_table[qq? qq : ref_base];
+ if (!p->is_del && !p->is_refskip && q < 4) x |= 1 << 21 | q << 16, y |= q;
+ bm->aux->info16[n] = y;
+ bm->aux->info[n++] = x;
+ }
+ rms = (uint8_t)(sqrt((double)rms / n) + .499);
+ if (bm->errmod == BAM_ERRMOD_MAQ2) {
+ errmod_cal(bm->aux->em, n, 4, bm->aux->info16, p);
+ goto goto_glf;
+ }
+ ks_introsort(uint32_t, n, bm->aux->info);
+ // generate esum and fsum
+ b = (glf_call_aux_t*)calloc(1, sizeof(glf_call_aux_t));
+ for (k = 0; k != 8; ++k) w[k] = 0;
+ for (j = n - 1; j >= 0; --j) { // calculate esum and fsum
+ uint32_t info = bm->aux->info[j];
+ if (info>>24 < 4 && (info>>8&0x3f) != 0) info = 4<<24 | (info&0xffffff);
+ k = info>>16&7;
+ if (info>>24 > 0) {
+ b->esum[k&3] += bm->fk[w[k]] * (info>>24);
+ b->fsum[k&3] += bm->fk[w[k]];
+ if (w[k] < 0xff) ++w[k];
+ ++b->c[k&3];
+ }
+ }
+ // rescale ->c[]
+ for (j = c = 0; j != 4; ++j) c += b->c[j];
+ if (c > 255) {
+ for (j = 0; j != 4; ++j) b->c[j] = (int)(254.0 * b->c[j] / c + 0.5);
+ for (j = c = 0; j != 4; ++j) c += b->c[j];
+ }
+ if (bm->errmod == BAM_ERRMOD_MAQ) {
+ // generate likelihood
+ for (j = 0; j != 4; ++j) {
+ // homozygous
+ float tmp1, tmp3;
+ int tmp2, bar_e;
+ for (k = 0, tmp1 = tmp3 = 0.0, tmp2 = 0; k != 4; ++k) {
+ if (j == k) continue;
+ tmp1 += b->esum[k]; tmp2 += b->c[k]; tmp3 += b->fsum[k];
+ }
+ if (tmp2) {
+ bar_e = (int)(tmp1 / tmp3 + 0.5);
+ if (bar_e < 4) bar_e = 4; // should not happen
+ if (bar_e > 63) bar_e = 63;
+ p[j<<2|j] = tmp1 + bm->coef[bar_e<<16|c<<8|tmp2];
+ } else p[j<<2|j] = 0.0; // all the bases are j
+ // heterozygous
+ for (k = j + 1; k < 4; ++k) {
+ for (i = 0, tmp2 = 0, tmp1 = tmp3 = 0.0; i != 4; ++i) {
+ if (i == j || i == k) continue;
+ tmp1 += b->esum[i]; tmp2 += b->c[i]; tmp3 += b->fsum[i];
+ }
+ if (tmp2) {
+ bar_e = (int)(tmp1 / tmp3 + 0.5);
+ if (bar_e < 4) bar_e = 4;
+ if (bar_e > 63) bar_e = 63;
+ p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]] + tmp1 + bm->coef[bar_e<<16|c<<8|tmp2];
+ } else p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]]; // all the bases are either j or k
+ }
+ //
+ for (k = 0; k != 4; ++k)
+ if (p[j<<2|k] < 0.0) p[j<<2|k] = 0.0;
+ }
+
+ { // fix p[k<<2|k]
+ float max1, max2, min1, min2;
+ int max_k, min_k;
+ max_k = min_k = -1;
+ max1 = max2 = -1.0; min1 = min2 = 1e30;
+ for (k = 0; k < 4; ++k) {
+ if (b->esum[k] > max1) {
+ max2 = max1; max1 = b->esum[k]; max_k = k;
+ } else if (b->esum[k] > max2) max2 = b->esum[k];
+ }
+ for (k = 0; k < 4; ++k) {
+ if (p[k<<2|k] < min1) {
+ min2 = min1; min1 = p[k<<2|k]; min_k = k;
+ } else if (p[k<<2|k] < min2) min2 = p[k<<2|k];
+ }
+ if (max1 > max2 && (min_k != max_k || min1 + 1.0 > min2))
+ p[max_k<<2|max_k] = min1 > 1.0? min1 - 1.0 : 0.0;
+ }
+ } else if (bm->errmod == BAM_ERRMOD_SOAP) { // apply the SOAP model
+ // generate likelihood
+ for (j = 0; j != 4; ++j) {
+ float tmp;
+ // homozygous
+ for (k = 0, tmp = 0.0; k != 4; ++k)
+ if (j != k) tmp += b->esum[k];
+ p[j<<2|j] = tmp;
+ // heterozygous
+ for (k = j + 1; k < 4; ++k) {
+ for (i = 0, tmp = 0.0; i != 4; ++i)
+ if (i != j && i != k) tmp += b->esum[i];
+ p[j<<2|k] = p[k<<2|j] = -4.343 * bm->lhet[b->c[j]<<8|b->c[k]] + tmp;
+ }
+ }
+ }
+
+goto_glf:
+ // convert necessary information to glf1_t
+ g->ref_base = ref_base; g->max_mapQ = rms;
+ g->depth = n > 16777215? 16777215 : n;
+ for (j = 0; j != 4; ++j)
+ for (k = j; k < 4; ++k)
+ if (p[j<<2|k] < min_p) min_p = p[j<<2|k];
+ g->min_lk = min_p > 255.0? 255 : (int)(min_p + 0.5);
+ for (j = c = 0; j != 4; ++j)
+ for (k = j; k < 4; ++k)
+ g->lk[c++] = p[j<<2|k]-min_p > 255.0? 255 : (int)(p[j<<2|k]-min_p + 0.5);
+
+ free(b);
+ return g;
+}
+
+uint32_t glf2cns(const glf1_t *g, int q_r)
+{
+ int i, j, k, p[10], ref4;
+ uint32_t x = 0;
+ ref4 = bam_nt16_nt4_table[g->ref_base];
+ for (i = k = 0; i < 4; ++i)
+ for (j = i; j < 4; ++j) {
+ int prior = (i == ref4 && j == ref4? 0 : i == ref4 || j == ref4? q_r : q_r + 3);
+ p[k] = (g->lk[k] + prior)<<4 | i<<2 | j;
+ ++k;
+ }
+ for (i = 1; i < 10; ++i) // insertion sort
+ for (j = i; j > 0 && p[j] < p[j-1]; --j)
+ k = p[j], p[j] = p[j-1], p[j-1] = k;
+ x = (1u<<(p[0]&3) | 1u<<(p[0]>>2&3)) << 28; // the best genotype
+ x |= (uint32_t)g->max_mapQ << 16; // rms mapQ
+ x |= ((p[1]>>4) - (p[0]>>4) < 256? (p[1]>>4) - (p[0]>>4) : 255) << 8; // consensus Q
+ for (k = 0; k < 10; ++k)
+ if ((p[k]&0xf) == (ref4<<2|ref4)) break;
+ if (k == 10) k = 9;
+ x |= (p[k]>>4) - (p[0]>>4) < 256? (p[k]>>4) - (p[0]>>4) : 255; // snp Q
+ return x;
+}
+
+uint32_t bam_maqcns_call(int n, const bam_pileup1_t *pl, bam_maqcns_t *bm)
+{
+ glf1_t *g;
+ uint32_t x;
+ if (n) {
+ g = bam_maqcns_glfgen(n, pl, 0xf, bm);
+ x = g->depth == 0? (0xfU<<28 | 0xfU<<24) : glf2cns(g, (int)(bm->q_r + 0.5));
+ free(g);
+ } else x = 0xfU<<28 | 0xfU<<24;
+ return x;
+}
+
+/************** *****************/
+
+bam_maqindel_opt_t *bam_maqindel_opt_init()
+{
+ bam_maqindel_opt_t *mi = (bam_maqindel_opt_t*)calloc(1, sizeof(bam_maqindel_opt_t));
+ mi->q_indel = 40;
+ mi->r_indel = 0.00015;
+ mi->r_snp = 0.001;
+ //
+ mi->mm_penalty = 3;
+ mi->indel_err = 4;
+ mi->ambi_thres = 10;
+ return mi;
+}
+
+void bam_maqindel_ret_destroy(bam_maqindel_ret_t *mir)
+{
+ if (mir == 0) return;
+ free(mir->s[0]); free(mir->s[1]); free(mir);
+}
+
+int bam_tpos2qpos(const bam1_core_t *c, const uint32_t *cigar, int32_t tpos, int is_left, int32_t *_tpos)
+{
+ int k, x = c->pos, y = 0, last_y = 0;
+ *_tpos = c->pos;
+ for (k = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k] & BAM_CIGAR_MASK;
+ int l = cigar[k] >> BAM_CIGAR_SHIFT;
+ if (op == BAM_CMATCH) {
+ if (c->pos > tpos) return y;
+ if (x + l > tpos) {
+ *_tpos = tpos;
+ return y + (tpos - x);
+ }
+ x += l; y += l;
+ last_y = y;
+ } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
+ else if (op == BAM_CDEL || op == BAM_CREF_SKIP) {
+ if (x + l > tpos) {
+ *_tpos = is_left? x : x + l;
+ return y;
+ }
+ x += l;
+ }
+ }
+ *_tpos = x;
+ return last_y;
+}
+
+#define MINUS_CONST 0x10000000
+
+bam_maqindel_ret_t *bam_maqindel(int n, int pos, const bam_maqindel_opt_t *mi, const bam_pileup1_t *pl, const char *ref,
+ int _n_types, int *_types)
+{
+ int i, j, n_types, *types, left, right, max_rd_len = 0;
+ bam_maqindel_ret_t *ret = 0;
+ // if there is no proposed indel, check if there is an indel from the alignment
+ if (_n_types == 0) {
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (!(p->b->core.flag&BAM_FUNMAP) && p->indel != 0) break;
+ }
+ if (i == n) return 0; // no indel
+ }
+ { // calculate how many types of indels are available (set n_types and types)
+ int m;
+ uint32_t *aux;
+ aux = (uint32_t*)calloc(n + _n_types + 1, 4);
+ m = 0;
+ aux[m++] = MINUS_CONST; // zero indel is always a type
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (!(p->b->core.flag&BAM_FUNMAP) && p->indel != 0)
+ aux[m++] = MINUS_CONST + p->indel;
+ j = bam_cigar2qlen(&p->b->core, bam1_cigar(p->b));
+ if (j > max_rd_len) max_rd_len = j;
+ }
+ if (_n_types) // then also add this to aux[]
+ for (i = 0; i < _n_types; ++i)
+ if (_types[i]) aux[m++] = MINUS_CONST + _types[i];
+ ks_introsort(uint32_t, m, aux);
+ // squeeze out identical types
+ for (i = 1, n_types = 1; i < m; ++i)
+ if (aux[i] != aux[i-1]) ++n_types;
+ types = (int*)calloc(n_types, sizeof(int));
+ j = 0;
+ types[j++] = aux[0] - MINUS_CONST;
+ for (i = 1; i < m; ++i) {
+ if (aux[i] != aux[i-1])
+ types[j++] = aux[i] - MINUS_CONST;
+ }
+ free(aux);
+ }
+ { // calculate left and right boundary
+ left = pos > INDEL_WINDOW_SIZE? pos - INDEL_WINDOW_SIZE : 0;
+ right = pos + INDEL_WINDOW_SIZE;
+ if (types[0] < 0) right -= types[0];
+ // in case the alignments stand out the reference
+ for (i = pos; i < right; ++i)
+ if (ref[i] == 0) break;
+ right = i;
+ }
+ { // the core part
+ char *ref2, *rs, *inscns = 0;
+ int qr_snp, k, l, *score, *pscore, max_ins = types[n_types-1];
+ qr_snp = (int)(-4.343 * log(mi->r_snp) + .499);
+ if (max_ins > 0) { // get the consensus of inserted sequences
+ int *inscns_aux = (int*)calloc(4 * n_types * max_ins, sizeof(int));
+ // count occurrences
+ for (i = 0; i < n_types; ++i) {
+ if (types[i] <= 0) continue; // not insertion
+ for (j = 0; j < n; ++j) {
+ const bam_pileup1_t *p = pl + j;
+ if (!(p->b->core.flag&BAM_FUNMAP) && p->indel == types[i]) {
+ for (k = 1; k <= p->indel; ++k) {
+ int c = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos + k)];
+ if (c < 4) ++inscns_aux[i*max_ins*4 + (k-1)*4 + c];
+ }
+ }
+ }
+ }
+ // construct the consensus of inserted sequence
+ inscns = (char*)calloc(n_types * max_ins, sizeof(char));
+ for (i = 0; i < n_types; ++i) {
+ for (j = 0; j < types[i]; ++j) {
+ int max = 0, max_k = -1, *ia = inscns_aux + i*max_ins*4 + j*4;
+ for (k = 0; k < 4; ++k) {
+ if (ia[k] > max) {
+ max = ia[k];
+ max_k = k;
+ }
+ }
+ inscns[i*max_ins + j] = max? 1<<max_k : 15;
+ }
+ }
+ free(inscns_aux);
+ }
+ // calculate score
+ ref2 = (char*)calloc(right - left + types[n_types-1] + 2, 1);
+ rs = (char*)calloc(right - left + max_rd_len + types[n_types-1] + 2, 1);
+ score = (int*)calloc(n_types * n, sizeof(int));
+ pscore = (int*)calloc(n_types * n, sizeof(int));
+ for (i = 0; i < n_types; ++i) {
+ ka_param_t ap = ka_param_blast;
+ ap.band_width = 2 * types[n_types - 1] + 2;
+ ap.gap_end_ext = 0;
+ // write ref2
+ for (k = 0, j = left; j <= pos; ++j)
+ ref2[k++] = bam_nt16_nt4_table[bam_nt16_table[(int)ref[j]]];
+ if (types[i] <= 0) j += -types[i];
+ else for (l = 0; l < types[i]; ++l)
+ ref2[k++] = bam_nt16_nt4_table[(int)inscns[i*max_ins + l]];
+ if (types[0] < 0) { // mask deleted sequences
+ int jj, tmp = types[i] >= 0? -types[0] : -types[0] + types[i];
+ for (jj = 0; jj < tmp && j < right && ref[j]; ++jj, ++j)
+ ref2[k++] = 4;
+ }
+ for (; j < right && ref[j]; ++j)
+ ref2[k++] = bam_nt16_nt4_table[bam_nt16_table[(int)ref[j]]];
+ if (j < right) right = j;
+ // calculate score for each read
+ for (j = 0; j < n; ++j) {
+ const bam_pileup1_t *p = pl + j;
+ int qbeg, qend, tbeg, tend;
+ if (p->b->core.flag & BAM_FUNMAP) continue;
+ qbeg = bam_tpos2qpos(&p->b->core, bam1_cigar(p->b), left, 0, &tbeg);
+ qend = bam_tpos2qpos(&p->b->core, bam1_cigar(p->b), right, 1, &tend);
+ assert(tbeg >= left);
+ for (l = qbeg; l < qend; ++l)
+ rs[l - qbeg] = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), l)];
+ {
+ int x, y, n_acigar, ps;
+ uint32_t *acigar;
+ ps = 0;
+ if (tend - tbeg + types[i] <= 0) {
+ score[i*n+j] = -(1<<20);
+ pscore[i*n+j] = 1<<20;
+ continue;
+ }
+ acigar = ka_global_core((uint8_t*)ref2 + tbeg - left, tend - tbeg + types[i], (uint8_t*)rs, qend - qbeg, &ap, &score[i*n+j], &n_acigar);
+ x = tbeg - left; y = 0;
+ for (l = 0; l < n_acigar; ++l) {
+ int op = acigar[l]&0xf;
+ int len = acigar[l]>>4;
+ if (op == BAM_CMATCH) {
+ int k;
+ for (k = 0; k < len; ++k)
+ if (ref2[x+k] != rs[y+k] && ref2[x+k] < 4)
+ ps += bam1_qual(p->b)[y+k] < qr_snp? bam1_qual(p->b)[y+k] : qr_snp;
+ x += len; y += len;
+ } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) {
+ if (op == BAM_CINS && l > 0 && l < n_acigar - 1) ps += mi->q_indel * len;
+ y += len;
+ } else if (op == BAM_CDEL) {
+ if (l > 0 && l < n_acigar - 1) ps += mi->q_indel * len;
+ x += len;
+ }
+ }
+ pscore[i*n+j] = ps;
+ /*if (1) { // for debugging only
+ fprintf(pysamerr, "id=%d, pos=%d, type=%d, j=%d, score=%d, psore=%d, %d, %d, %d, %d, %d, ",
+ j, pos+1, types[i], j, score[i*n+j], pscore[i*n+j], tbeg, tend, qbeg, qend, mi->q_indel);
+ for (l = 0; l < n_acigar; ++l) fprintf(pysamerr, "%d%c", acigar[l]>>4, "MIDS"[acigar[l]&0xf]);
+ fprintf(pysamerr, "\n");
+ for (l = 0; l < tend - tbeg + types[i]; ++l) fputc("ACGTN"[ref2[l+tbeg-left]], pysamerr);
+ fputc('\n', pysamerr);
+ for (l = 0; l < qend - qbeg; ++l) fputc("ACGTN"[rs[l]], pysamerr);
+ fputc('\n', pysamerr);
+ }*/
+ free(acigar);
+ }
+ }
+ }
+ { // get final result
+ int *sum, max1, max2, max1_i, max2_i;
+ // pick up the best two score
+ sum = (int*)calloc(n_types, sizeof(int));
+ for (i = 0; i < n_types; ++i)
+ for (j = 0; j < n; ++j)
+ sum[i] += -pscore[i*n+j];
+ max1 = max2 = -0x7fffffff; max1_i = max2_i = -1;
+ for (i = 0; i < n_types; ++i) {
+ if (sum[i] > max1) {
+ max2 = max1; max2_i = max1_i; max1 = sum[i]; max1_i = i;
+ } else if (sum[i] > max2) {
+ max2 = sum[i]; max2_i = i;
+ }
+ }
+ free(sum);
+ // write ret
+ ret = (bam_maqindel_ret_t*)calloc(1, sizeof(bam_maqindel_ret_t));
+ ret->indel1 = types[max1_i]; ret->indel2 = types[max2_i];
+ ret->s[0] = (char*)calloc(abs(ret->indel1) + 2, 1);
+ ret->s[1] = (char*)calloc(abs(ret->indel2) + 2, 1);
+ // write indel sequence
+ if (ret->indel1 > 0) {
+ ret->s[0][0] = '+';
+ for (k = 0; k < ret->indel1; ++k)
+ ret->s[0][k+1] = bam_nt16_rev_table[(int)inscns[max1_i*max_ins + k]];
+ } else if (ret->indel1 < 0) {
+ ret->s[0][0] = '-';
+ for (k = 0; k < -ret->indel1 && ref[pos + k + 1]; ++k)
+ ret->s[0][k+1] = ref[pos + k + 1];
+ } else ret->s[0][0] = '*';
+ if (ret->indel2 > 0) {
+ ret->s[1][0] = '+';
+ for (k = 0; k < ret->indel2; ++k)
+ ret->s[1][k+1] = bam_nt16_rev_table[(int)inscns[max2_i*max_ins + k]];
+ } else if (ret->indel2 < 0) {
+ ret->s[1][0] = '-';
+ for (k = 0; k < -ret->indel2 && ref[pos + k + 1]; ++k)
+ ret->s[1][k+1] = ref[pos + k + 1];
+ } else ret->s[1][0] = '*';
+ // write count
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (p->indel == ret->indel1) ++ret->cnt1;
+ else if (p->indel == ret->indel2) ++ret->cnt2;
+ else ++ret->cnt_anti;
+ }
+ { // write gl[]
+ int tmp, seq_err = 0;
+ double x = 1.0;
+ tmp = max1_i - max2_i;
+ if (tmp < 0) tmp = -tmp;
+ for (j = 0; j < tmp + 1; ++j) x *= INDEL_EXT_DEP;
+ seq_err = mi->q_indel * (1.0 - x) / (1.0 - INDEL_EXT_DEP);
+ ret->gl[0] = ret->gl[1] = 0;
+ for (j = 0; j < n; ++j) {
+ int s1 = pscore[max1_i*n + j], s2 = pscore[max2_i*n + j];
+ //fprintf(pysamerr, "id=%d, %d, %d, %d, %d, %d\n", j, pl[j].b->core.pos+1, types[max1_i], types[max2_i], s1, s2);
+ if (s1 > s2) ret->gl[0] += s1 - s2 < seq_err? s1 - s2 : seq_err;
+ else ret->gl[1] += s2 - s1 < seq_err? s2 - s1 : seq_err;
+ }
+ }
+ // write cnt_ref and cnt_ambi
+ if (max1_i != 0 && max2_i != 0) {
+ for (j = 0; j < n; ++j) {
+ int diff1 = score[j] - score[max1_i * n + j];
+ int diff2 = score[j] - score[max2_i * n + j];
+ if (diff1 > 0 && diff2 > 0) ++ret->cnt_ref;
+ else if (diff1 == 0 || diff2 == 0) ++ret->cnt_ambi;
+ }
+ }
+ }
+ free(score); free(pscore); free(ref2); free(rs); free(inscns);
+ }
+ { // call genotype
+ int q[3], qr_indel = (int)(-4.343 * log(mi->r_indel) + 0.5);
+ int min1, min2, min1_i;
+ q[0] = ret->gl[0] + (ret->s[0][0] != '*'? 0 : 0) * qr_indel;
+ q[1] = ret->gl[1] + (ret->s[1][0] != '*'? 0 : 0) * qr_indel;
+ q[2] = n * 3 + (ret->s[0][0] == '*' || ret->s[1][0] == '*'? 1 : 1) * qr_indel;
+ min1 = min2 = 0x7fffffff; min1_i = -1;
+ for (i = 0; i < 3; ++i) {
+ if (q[i] < min1) {
+ min2 = min1; min1 = q[i]; min1_i = i;
+ } else if (q[i] < min2) min2 = q[i];
+ }
+ ret->gt = min1_i;
+ ret->q_cns = min2 - min1;
+ // set q_ref
+ if (ret->gt < 2) ret->q_ref = (ret->s[ret->gt][0] == '*')? 0 : q[1-ret->gt] - q[ret->gt] - qr_indel - 3;
+ else ret->q_ref = (ret->s[0][0] == '*')? q[0] - q[2] : q[1] - q[2];
+ if (ret->q_ref < 0) ret->q_ref = 0;
+ }
+ free(types);
+ return ret;
+}
#include "glf.h"
+#define BAM_ERRMOD_MAQ2 0
+#define BAM_ERRMOD_MAQ 1
+#define BAM_ERRMOD_SOAP 2
+
struct __bmc_aux_t;
typedef struct {
float het_rate, theta;
- int n_hap, cap_mapQ, is_soap;
+ int n_hap, cap_mapQ, errmod, min_baseQ;
float eta, q_r;
double *fk, *coef;
+++ /dev/null
-#include <stdlib.h>
-#include <string.h>
-#include "bam.h"
-
-// currently, this function ONLY works if each read has one hit
-void bam_mating_core(bamFile in, bamFile out)
-{
- bam_header_t *header;
- bam1_t *b[2];
- int curr, has_prev;
-
- header = bam_header_read(in);
- bam_header_write(out, header);
-
- b[0] = bam_init1();
- b[1] = bam_init1();
- curr = 0; has_prev = 0;
- while (bam_read1(in, b[curr]) >= 0) {
- bam1_t *cur = b[curr], *pre = b[1-curr];
- if (has_prev) {
- if (strcmp(bam1_qname(cur), bam1_qname(pre)) == 0) { // identical pair name
- cur->core.mtid = pre->core.tid; cur->core.mpos = pre->core.pos;
- pre->core.mtid = cur->core.tid; pre->core.mpos = cur->core.pos;
- if (pre->core.tid == cur->core.tid && !(cur->core.flag&(BAM_FUNMAP|BAM_FMUNMAP))
- && !(pre->core.flag&(BAM_FUNMAP|BAM_FMUNMAP)))
- {
- uint32_t cur5, pre5;
- cur5 = (cur->core.flag&BAM_FREVERSE)? bam_calend(&cur->core, bam1_cigar(cur)) : cur->core.pos;
- pre5 = (pre->core.flag&BAM_FREVERSE)? bam_calend(&pre->core, bam1_cigar(pre)) : pre->core.pos;
- cur->core.isize = pre5 - cur5; pre->core.isize = cur5 - pre5;
- } else cur->core.isize = pre->core.isize = 0;
- if (pre->core.flag&BAM_FREVERSE) cur->core.flag |= BAM_FMREVERSE;
- else cur->core.flag &= ~BAM_FMREVERSE;
- if (cur->core.flag&BAM_FREVERSE) pre->core.flag |= BAM_FMREVERSE;
- else pre->core.flag &= ~BAM_FMREVERSE;
- if (cur->core.flag & BAM_FUNMAP) { pre->core.flag |= BAM_FMUNMAP; pre->core.flag &= ~BAM_FPROPER_PAIR; }
- if (pre->core.flag & BAM_FUNMAP) { cur->core.flag |= BAM_FMUNMAP; cur->core.flag &= ~BAM_FPROPER_PAIR; }
- bam_write1(out, pre);
- bam_write1(out, cur);
- has_prev = 0;
- } else { // unpaired or singleton
- pre->core.mtid = -1; pre->core.mpos = -1; pre->core.isize = 0;
- if (pre->core.flag & BAM_FPAIRED) {
- pre->core.flag |= BAM_FMUNMAP;
- pre->core.flag &= ~BAM_FMREVERSE & ~BAM_FPROPER_PAIR;
- }
- bam_write1(out, pre);
- }
- } else has_prev = 1;
- curr = 1 - curr;
- }
- if (has_prev) bam_write1(out, b[1-curr]);
- bam_header_destroy(header);
- bam_destroy1(b[0]);
- bam_destroy1(b[1]);
-}
-
-int bam_mating(int argc, char *argv[])
-{
- bamFile in, out;
- if (argc < 3) {
- fprintf(stderr, "samtools fixmate <in.nameSrt.bam> <out.nameSrt.bam>\n");
- return 1;
- }
- in = (strcmp(argv[1], "-") == 0)? bam_dopen(fileno(stdin), "r") : bam_open(argv[1], "r");
- out = (strcmp(argv[2], "-") == 0)? bam_dopen(fileno(stdout), "w") : bam_open(argv[2], "w");
- bam_mating_core(in, out);
- bam_close(in); bam_close(out);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <string.h>
+#include "bam.h"
+
+// currently, this function ONLY works if each read has one hit
+void bam_mating_core(bamFile in, bamFile out)
+{
+ bam_header_t *header;
+ bam1_t *b[2];
+ int curr, has_prev;
+
+ header = bam_header_read(in);
+ bam_header_write(out, header);
+
+ b[0] = bam_init1();
+ b[1] = bam_init1();
+ curr = 0; has_prev = 0;
+ while (bam_read1(in, b[curr]) >= 0) {
+ bam1_t *cur = b[curr], *pre = b[1-curr];
+ if (has_prev) {
+ if (strcmp(bam1_qname(cur), bam1_qname(pre)) == 0) { // identical pair name
+ cur->core.mtid = pre->core.tid; cur->core.mpos = pre->core.pos;
+ pre->core.mtid = cur->core.tid; pre->core.mpos = cur->core.pos;
+ if (pre->core.tid == cur->core.tid && !(cur->core.flag&(BAM_FUNMAP|BAM_FMUNMAP))
+ && !(pre->core.flag&(BAM_FUNMAP|BAM_FMUNMAP)))
+ {
+ uint32_t cur5, pre5;
+ cur5 = (cur->core.flag&BAM_FREVERSE)? bam_calend(&cur->core, bam1_cigar(cur)) : cur->core.pos;
+ pre5 = (pre->core.flag&BAM_FREVERSE)? bam_calend(&pre->core, bam1_cigar(pre)) : pre->core.pos;
+ cur->core.isize = pre5 - cur5; pre->core.isize = cur5 - pre5;
+ } else cur->core.isize = pre->core.isize = 0;
+ if (pre->core.flag&BAM_FREVERSE) cur->core.flag |= BAM_FMREVERSE;
+ else cur->core.flag &= ~BAM_FMREVERSE;
+ if (cur->core.flag&BAM_FREVERSE) pre->core.flag |= BAM_FMREVERSE;
+ else pre->core.flag &= ~BAM_FMREVERSE;
+ if (cur->core.flag & BAM_FUNMAP) { pre->core.flag |= BAM_FMUNMAP; pre->core.flag &= ~BAM_FPROPER_PAIR; }
+ if (pre->core.flag & BAM_FUNMAP) { cur->core.flag |= BAM_FMUNMAP; cur->core.flag &= ~BAM_FPROPER_PAIR; }
+ bam_write1(out, pre);
+ bam_write1(out, cur);
+ has_prev = 0;
+ } else { // unpaired or singleton
+ pre->core.mtid = -1; pre->core.mpos = -1; pre->core.isize = 0;
+ if (pre->core.flag & BAM_FPAIRED) {
+ pre->core.flag |= BAM_FMUNMAP;
+ pre->core.flag &= ~BAM_FMREVERSE & ~BAM_FPROPER_PAIR;
+ }
+ bam_write1(out, pre);
+ }
+ } else has_prev = 1;
+ curr = 1 - curr;
+ }
+ if (has_prev) bam_write1(out, b[1-curr]);
+ bam_header_destroy(header);
+ bam_destroy1(b[0]);
+ bam_destroy1(b[1]);
+}
+
+int bam_mating(int argc, char *argv[])
+{
+ bamFile in, out;
+ if (argc < 3) {
+ fprintf(pysamerr, "samtools fixmate <in.nameSrt.bam> <out.nameSrt.bam>\n");
+ return 1;
+ }
+ in = (strcmp(argv[1], "-") == 0)? bam_dopen(fileno(stdin), "r") : bam_open(argv[1], "r");
+ out = (strcmp(argv[2], "-") == 0)? bam_dopen(fileno(stdout), "w") : bam_open(argv[2], "w");
+ bam_mating_core(in, out);
+ bam_close(in); bam_close(out);
+ return 0;
+}
+++ /dev/null
-#include <unistd.h>
-#include <assert.h>
-#include <string.h>
-#include <ctype.h>
-#include "faidx.h"
-#include "sam.h"
-#include "kstring.h"
-
-void bam_fillmd1_core(bam1_t *b, char *ref, int is_equal, int max_nm)
-{
- uint8_t *seq = bam1_seq(b);
- uint32_t *cigar = bam1_cigar(b);
- bam1_core_t *c = &b->core;
- int i, x, y, u = 0;
- kstring_t *str;
- uint8_t *old_md, *old_nm;
- int32_t old_nm_i = -1, nm = 0;
-
- str = (kstring_t*)calloc(1, sizeof(kstring_t));
- for (i = y = 0, x = c->pos; i < c->n_cigar; ++i) {
- int j, l = cigar[i]>>4, op = cigar[i]&0xf;
- if (op == BAM_CMATCH) {
- for (j = 0; j < l; ++j) {
- int z = y + j;
- int c1 = bam1_seqi(seq, z), c2 = bam_nt16_table[(int)ref[x+j]];
- if (ref[x+j] == 0) break; // out of boundary
- if ((c1 == c2 && c1 != 15 && c2 != 15) || c1 == 0) { // a match
- if (is_equal) seq[z/2] &= (z&1)? 0xf0 : 0x0f;
- ++u;
- } else {
- ksprintf(str, "%d", u);
- kputc(ref[x+j], str);
- u = 0; ++nm;
- }
- }
- if (j < l) break;
- x += l; y += l;
- } else if (op == BAM_CDEL) {
- ksprintf(str, "%d", u);
- kputc('^', str);
- for (j = 0; j < l; ++j) {
- if (ref[x+j] == 0) break;
- kputc(ref[x+j], str);
- }
- u = 0;
- if (j < l) break;
- x += l; nm += l;
- } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) {
- y += l;
- if (op == BAM_CINS) nm += l;
- } else if (op == BAM_CREF_SKIP) {
- x += l;
- }
- }
- ksprintf(str, "%d", u);
- // apply max_nm
- if (max_nm > 0 && nm >= max_nm) {
- for (i = y = 0, x = c->pos; i < c->n_cigar; ++i) {
- int j, l = cigar[i]>>4, op = cigar[i]&0xf;
- if (op == BAM_CMATCH) {
- for (j = 0; j < l; ++j) {
- int z = y + j;
- int c1 = bam1_seqi(seq, z), c2 = bam_nt16_table[(int)ref[x+j]];
- if (ref[x+j] == 0) break; // out of boundary
- if ((c1 == c2 && c1 != 15 && c2 != 15) || c1 == 0) { // a match
- seq[z/2] |= (z&1)? 0x0f : 0xf0;
- bam1_qual(b)[z] = 0;
- }
- }
- if (j < l) break;
- x += l; y += l;
- } else if (op == BAM_CDEL || op == BAM_CREF_SKIP) x += l;
- else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
- }
- }
- // update NM
- old_nm = bam_aux_get(b, "NM");
- if (c->flag & BAM_FUNMAP) return;
- if (old_nm) old_nm_i = bam_aux2i(old_nm);
- if (!old_nm) bam_aux_append(b, "NM", 'i', 4, (uint8_t*)&nm);
- else if (nm != old_nm_i) {
- fprintf(stderr, "[bam_fillmd1] different NM for read '%s': %d -> %d\n", bam1_qname(b), old_nm_i, nm);
- bam_aux_del(b, old_nm);
- bam_aux_append(b, "NM", 'i', 4, (uint8_t*)&nm);
- }
- // update MD
- old_md = bam_aux_get(b, "MD");
- if (!old_md) bam_aux_append(b, "MD", 'Z', str->l + 1, (uint8_t*)str->s);
- else {
- int is_diff = 0;
- if (strlen((char*)old_md+1) == str->l) {
- for (i = 0; i < str->l; ++i)
- if (toupper(old_md[i+1]) != toupper(str->s[i]))
- break;
- if (i < str->l) is_diff = 1;
- } else is_diff = 1;
- if (is_diff) {
- fprintf(stderr, "[bam_fillmd1] different MD for read '%s': '%s' -> '%s'\n", bam1_qname(b), old_md+1, str->s);
- bam_aux_del(b, old_md);
- bam_aux_append(b, "MD", 'Z', str->l + 1, (uint8_t*)str->s);
- }
- }
- free(str->s); free(str);
-}
-
-void bam_fillmd1(bam1_t *b, char *ref, int is_equal)
-{
- bam_fillmd1_core(b, ref, is_equal, 0);
-}
-
-int bam_fillmd(int argc, char *argv[])
-{
- int c, is_equal = 0, tid = -2, ret, len, is_bam_out, is_sam_in, is_uncompressed, max_nm = 0;
- samfile_t *fp, *fpout = 0;
- faidx_t *fai;
- char *ref = 0, mode_w[8], mode_r[8];
- bam1_t *b;
-
- is_bam_out = is_sam_in = is_uncompressed = 0;
- mode_w[0] = mode_r[0] = 0;
- strcpy(mode_r, "r"); strcpy(mode_w, "w");
- while ((c = getopt(argc, argv, "eubSn:")) >= 0) {
- switch (c) {
- case 'e': is_equal = 1; break;
- case 'b': is_bam_out = 1; break;
- case 'u': is_uncompressed = is_bam_out = 1; break;
- case 'S': is_sam_in = 1; break;
- case 'n': max_nm = atoi(optarg); break;
- default: fprintf(stderr, "[bam_fillmd] unrecognized option '-%c'\n", c); return 1;
- }
- }
- if (!is_sam_in) strcat(mode_r, "b");
- if (is_bam_out) strcat(mode_w, "b");
- else strcat(mode_w, "h");
- if (is_uncompressed) strcat(mode_w, "u");
- if (optind + 1 >= argc) {
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: samtools fillmd [-eubS] <aln.bam> <ref.fasta>\n\n");
- fprintf(stderr, "Options: -e change identical bases to '='\n");
- fprintf(stderr, " -u uncompressed BAM output (for piping)\n");
- fprintf(stderr, " -b compressed BAM output\n");
- fprintf(stderr, " -S the input is SAM with header\n\n");
- return 1;
- }
- fp = samopen(argv[optind], mode_r, 0);
- if (fp == 0) return 1;
- if (is_sam_in && (fp->header == 0 || fp->header->n_targets == 0)) {
- fprintf(stderr, "[bam_fillmd] input SAM does not have header. Abort!\n");
- return 1;
- }
- fpout = samopen("-", mode_w, fp->header);
- fai = fai_load(argv[optind+1]);
-
- b = bam_init1();
- while ((ret = samread(fp, b)) >= 0) {
- if (b->core.tid >= 0) {
- if (tid != b->core.tid) {
- free(ref);
- ref = fai_fetch(fai, fp->header->target_name[b->core.tid], &len);
- tid = b->core.tid;
- if (ref == 0)
- fprintf(stderr, "[bam_fillmd] fail to find sequence '%s' in the reference.\n",
- fp->header->target_name[tid]);
- }
- if (ref) bam_fillmd1_core(b, ref, is_equal, max_nm);
- }
- samwrite(fpout, b);
- }
- bam_destroy1(b);
-
- free(ref);
- fai_destroy(fai);
- samclose(fp); samclose(fpout);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <unistd.h>
+#include <assert.h>
+#include <string.h>
+#include <ctype.h>
+#include <math.h>
+#include "faidx.h"
+#include "sam.h"
+#include "kstring.h"
+#include "kaln.h"
+#include "kprobaln.h"
+
+char bam_nt16_nt4_table[] = { 4, 0, 1, 4, 2, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4 };
+
+void bam_fillmd1_core(bam1_t *b, char *ref, int is_equal, int max_nm)
+{
+ uint8_t *seq = bam1_seq(b);
+ uint32_t *cigar = bam1_cigar(b);
+ bam1_core_t *c = &b->core;
+ int i, x, y, u = 0;
+ kstring_t *str;
+ uint8_t *old_md, *old_nm;
+ int32_t old_nm_i = -1, nm = 0;
+
+ str = (kstring_t*)calloc(1, sizeof(kstring_t));
+ for (i = y = 0, x = c->pos; i < c->n_cigar; ++i) {
+ int j, l = cigar[i]>>4, op = cigar[i]&0xf;
+ if (op == BAM_CMATCH) {
+ for (j = 0; j < l; ++j) {
+ int z = y + j;
+ int c1 = bam1_seqi(seq, z), c2 = bam_nt16_table[(int)ref[x+j]];
+ if (ref[x+j] == 0) break; // out of boundary
+ if ((c1 == c2 && c1 != 15 && c2 != 15) || c1 == 0) { // a match
+ if (is_equal) seq[z/2] &= (z&1)? 0xf0 : 0x0f;
+ ++u;
+ } else {
+ ksprintf(str, "%d", u);
+ kputc(ref[x+j], str);
+ u = 0; ++nm;
+ }
+ }
+ if (j < l) break;
+ x += l; y += l;
+ } else if (op == BAM_CDEL) {
+ ksprintf(str, "%d", u);
+ kputc('^', str);
+ for (j = 0; j < l; ++j) {
+ if (ref[x+j] == 0) break;
+ kputc(ref[x+j], str);
+ }
+ u = 0;
+ if (j < l) break;
+ x += l; nm += l;
+ } else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) {
+ y += l;
+ if (op == BAM_CINS) nm += l;
+ } else if (op == BAM_CREF_SKIP) {
+ x += l;
+ }
+ }
+ ksprintf(str, "%d", u);
+ // apply max_nm
+ if (max_nm > 0 && nm >= max_nm) {
+ for (i = y = 0, x = c->pos; i < c->n_cigar; ++i) {
+ int j, l = cigar[i]>>4, op = cigar[i]&0xf;
+ if (op == BAM_CMATCH) {
+ for (j = 0; j < l; ++j) {
+ int z = y + j;
+ int c1 = bam1_seqi(seq, z), c2 = bam_nt16_table[(int)ref[x+j]];
+ if (ref[x+j] == 0) break; // out of boundary
+ if ((c1 == c2 && c1 != 15 && c2 != 15) || c1 == 0) { // a match
+ seq[z/2] |= (z&1)? 0x0f : 0xf0;
+ bam1_qual(b)[z] = 0;
+ }
+ }
+ if (j < l) break;
+ x += l; y += l;
+ } else if (op == BAM_CDEL || op == BAM_CREF_SKIP) x += l;
+ else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
+ }
+ }
+ // update NM
+ old_nm = bam_aux_get(b, "NM");
+ if (c->flag & BAM_FUNMAP) return;
+ if (old_nm) old_nm_i = bam_aux2i(old_nm);
+ if (!old_nm) bam_aux_append(b, "NM", 'i', 4, (uint8_t*)&nm);
+ else if (nm != old_nm_i) {
+ fprintf(pysamerr, "[bam_fillmd1] different NM for read '%s': %d -> %d\n", bam1_qname(b), old_nm_i, nm);
+ bam_aux_del(b, old_nm);
+ bam_aux_append(b, "NM", 'i', 4, (uint8_t*)&nm);
+ }
+ // update MD
+ old_md = bam_aux_get(b, "MD");
+ if (!old_md) bam_aux_append(b, "MD", 'Z', str->l + 1, (uint8_t*)str->s);
+ else {
+ int is_diff = 0;
+ if (strlen((char*)old_md+1) == str->l) {
+ for (i = 0; i < str->l; ++i)
+ if (toupper(old_md[i+1]) != toupper(str->s[i]))
+ break;
+ if (i < str->l) is_diff = 1;
+ } else is_diff = 1;
+ if (is_diff) {
+ fprintf(pysamerr, "[bam_fillmd1] different MD for read '%s': '%s' -> '%s'\n", bam1_qname(b), old_md+1, str->s);
+ bam_aux_del(b, old_md);
+ bam_aux_append(b, "MD", 'Z', str->l + 1, (uint8_t*)str->s);
+ }
+ }
+ free(str->s); free(str);
+}
+
+void bam_fillmd1(bam1_t *b, char *ref, int is_equal)
+{
+ bam_fillmd1_core(b, ref, is_equal, 0);
+}
+
+int bam_cap_mapQ(bam1_t *b, char *ref, int thres)
+{
+ uint8_t *seq = bam1_seq(b), *qual = bam1_qual(b);
+ uint32_t *cigar = bam1_cigar(b);
+ bam1_core_t *c = &b->core;
+ int i, x, y, mm, q, len, clip_l, clip_q;
+ double t;
+ if (thres < 0) thres = 40; // set the default
+ mm = q = len = clip_l = clip_q = 0;
+ for (i = y = 0, x = c->pos; i < c->n_cigar; ++i) {
+ int j, l = cigar[i]>>4, op = cigar[i]&0xf;
+ if (op == BAM_CMATCH) {
+ for (j = 0; j < l; ++j) {
+ int z = y + j;
+ int c1 = bam1_seqi(seq, z), c2 = bam_nt16_table[(int)ref[x+j]];
+ if (ref[x+j] == 0) break; // out of boundary
+ if (c2 != 15 && c1 != 15 && qual[z] >= 13) { // not ambiguous
+ ++len;
+ if (c1 && c1 != c2 && qual[z] >= 13) { // mismatch
+ ++mm;
+ q += qual[z] > 33? 33 : qual[z];
+ }
+ }
+ }
+ if (j < l) break;
+ x += l; y += l; len += l;
+ } else if (op == BAM_CDEL) {
+ for (j = 0; j < l; ++j)
+ if (ref[x+j] == 0) break;
+ if (j < l) break;
+ x += l;
+ } else if (op == BAM_CSOFT_CLIP) {
+ for (j = 0; j < l; ++j) clip_q += qual[y+j];
+ clip_l += l;
+ y += l;
+ } else if (op == BAM_CHARD_CLIP) {
+ clip_q += 13 * l;
+ clip_l += l;
+ } else if (op == BAM_CINS) y += l;
+ else if (op == BAM_CREF_SKIP) x += l;
+ }
+ for (i = 0, t = 1; i < mm; ++i)
+ t *= (double)len / (i+1);
+ t = q - 4.343 * log(t) + clip_q / 5.;
+ if (t > thres) return -1;
+ if (t < 0) t = 0;
+ t = sqrt((thres - t) / thres) * thres;
+// fprintf(pysamerr, "%s %lf %d\n", bam1_qname(b), t, q);
+ return (int)(t + .499);
+}
+
+int bam_prob_realn_core(bam1_t *b, const char *ref, int flag)
+{
+ int k, i, bw, x, y, yb, ye, xb, xe, apply_baq = flag&1, extend_baq = flag>>1&1;
+ uint32_t *cigar = bam1_cigar(b);
+ bam1_core_t *c = &b->core;
+ kpa_par_t conf = kpa_par_def;
+ uint8_t *bq = 0, *zq = 0, *qual = bam1_qual(b);
+ if ((c->flag & BAM_FUNMAP) || b->core.l_qseq == 0) return -1; // do nothing
+ // test if BQ or ZQ is present
+ if ((bq = bam_aux_get(b, "BQ")) != 0) ++bq;
+ if ((zq = bam_aux_get(b, "ZQ")) != 0 && *zq == 'Z') ++zq;
+ if (bq && zq) { // remove the ZQ tag
+ bam_aux_del(b, zq-1);
+ zq = 0;
+ }
+ if (bq || zq) {
+ if ((apply_baq && zq) || (!apply_baq && bq)) return -3; // in both cases, do nothing
+ if (bq && apply_baq) { // then convert BQ to ZQ
+ for (i = 0; i < c->l_qseq; ++i)
+ qual[i] = qual[i] + 64 < bq[i]? 0 : qual[i] - ((int)bq[i] - 64);
+ *(bq - 3) = 'Z';
+ } else if (zq && !apply_baq) { // then convert ZQ to BQ
+ for (i = 0; i < c->l_qseq; ++i)
+ qual[i] += (int)zq[i] - 64;
+ *(zq - 3) = 'B';
+ }
+ return 0;
+ }
+ // find the start and end of the alignment
+ x = c->pos, y = 0, yb = ye = xb = xe = -1;
+ for (k = 0; k < c->n_cigar; ++k) {
+ int op, l;
+ op = cigar[k]&0xf; l = cigar[k]>>4;
+ if (op == BAM_CMATCH) {
+ if (yb < 0) yb = y;
+ if (xb < 0) xb = x;
+ ye = y + l; xe = x + l;
+ x += l; y += l;
+ } else if (op == BAM_CSOFT_CLIP || op == BAM_CINS) y += l;
+ else if (op == BAM_CDEL) x += l;
+ else if (op == BAM_CREF_SKIP) return -1; // do nothing if there is a reference skip
+ }
+ // set bandwidth and the start and the end
+ bw = 7;
+ if (abs((xe - xb) - (ye - yb)) > bw)
+ bw = abs((xe - xb) - (ye - yb)) + 3;
+ conf.bw = bw;
+ xb -= yb + bw/2; if (xb < 0) xb = 0;
+ xe += c->l_qseq - ye + bw/2;
+ if (xe - xb - c->l_qseq > bw)
+ xb += (xe - xb - c->l_qseq - bw) / 2, xe -= (xe - xb - c->l_qseq - bw) / 2;
+ { // glocal
+ uint8_t *s, *r, *q, *seq = bam1_seq(b), *bq;
+ int *state;
+ bq = calloc(c->l_qseq + 1, 1);
+ memcpy(bq, qual, c->l_qseq);
+ s = calloc(c->l_qseq, 1);
+ for (i = 0; i < c->l_qseq; ++i) s[i] = bam_nt16_nt4_table[bam1_seqi(seq, i)];
+ r = calloc(xe - xb, 1);
+ for (i = xb; i < xe; ++i) {
+ if (ref[i] == 0) { xe = i; break; }
+ r[i-xb] = bam_nt16_nt4_table[bam_nt16_table[(int)ref[i]]];
+ }
+ state = calloc(c->l_qseq, sizeof(int));
+ q = calloc(c->l_qseq, 1);
+ kpa_glocal(r, xe-xb, s, c->l_qseq, qual, &conf, state, q);
+ if (!extend_baq) { // in this block, bq[] is capped by base quality qual[]
+ for (k = 0, x = c->pos, y = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k]&0xf, l = cigar[k]>>4;
+ if (op == BAM_CMATCH) {
+ for (i = y; i < y + l; ++i) {
+ if ((state[i]&3) != 0 || state[i]>>2 != x - xb + (i - y)) bq[i] = 0;
+ else bq[i] = bq[i] < q[i]? bq[i] : q[i];
+ }
+ x += l; y += l;
+ } else if (op == BAM_CSOFT_CLIP || op == BAM_CINS) y += l;
+ else if (op == BAM_CDEL) x += l;
+ }
+ for (i = 0; i < c->l_qseq; ++i) bq[i] = qual[i] - bq[i] + 64; // finalize BQ
+ } else { // in this block, bq[] is BAQ that can be larger than qual[] (different from the above!)
+ uint8_t *left, *rght;
+ left = calloc(c->l_qseq, 1); rght = calloc(c->l_qseq, 1);
+ for (k = 0, x = c->pos, y = 0; k < c->n_cigar; ++k) {
+ int op = cigar[k]&0xf, l = cigar[k]>>4;
+ if (op == BAM_CMATCH) {
+ for (i = y; i < y + l; ++i)
+ bq[i] = ((state[i]&3) != 0 || state[i]>>2 != x - xb + (i - y))? 0 : q[i];
+ for (left[y] = bq[y], i = y + 1; i < y + l; ++i)
+ left[i] = bq[i] > left[i-1]? bq[i] : left[i-1];
+ for (rght[y+l-1] = bq[y+l-1], i = y + l - 2; i >= y; --i)
+ rght[i] = bq[i] > rght[i+1]? bq[i] : rght[i+1];
+ for (i = y; i < y + l; ++i)
+ bq[i] = left[i] < rght[i]? left[i] : rght[i];
+ x += l; y += l;
+ } else if (op == BAM_CSOFT_CLIP || op == BAM_CINS) y += l;
+ else if (op == BAM_CDEL) x += l;
+ }
+ for (i = 0; i < c->l_qseq; ++i) bq[i] = 64 + (qual[i] <= bq[i]? 0 : qual[i] - bq[i]); // finalize BQ
+ free(left); free(rght);
+ }
+ if (apply_baq) {
+ for (i = 0; i < c->l_qseq; ++i) qual[i] -= bq[i] - 64; // modify qual
+ bam_aux_append(b, "ZQ", 'Z', c->l_qseq + 1, bq);
+ } else bam_aux_append(b, "BQ", 'Z', c->l_qseq + 1, bq);
+ free(bq); free(s); free(r); free(q); free(state);
+ }
+ return 0;
+}
+
+int bam_prob_realn(bam1_t *b, const char *ref)
+{
+ return bam_prob_realn_core(b, ref, 1);
+}
+
+int bam_fillmd(int argc, char *argv[])
+{
+ int c, is_equal, tid = -2, ret, len, is_bam_out, is_sam_in, is_uncompressed, max_nm, is_realn, capQ, baq_flag;
+ samfile_t *fp, *fpout = 0;
+ faidx_t *fai;
+ char *ref = 0, mode_w[8], mode_r[8];
+ bam1_t *b;
+
+ is_equal = is_bam_out = is_sam_in = is_uncompressed = is_realn = max_nm = capQ = baq_flag = 0;
+ mode_w[0] = mode_r[0] = 0;
+ strcpy(mode_r, "r"); strcpy(mode_w, "w");
+ while ((c = getopt(argc, argv, "EreubSC:n:A")) >= 0) {
+ switch (c) {
+ case 'r': is_realn = 1; break;
+ case 'e': is_equal = 1; break;
+ case 'b': is_bam_out = 1; break;
+ case 'u': is_uncompressed = is_bam_out = 1; break;
+ case 'S': is_sam_in = 1; break;
+ case 'n': max_nm = atoi(optarg); break;
+ case 'C': capQ = atoi(optarg); break;
+ case 'A': baq_flag |= 1; break;
+ case 'E': baq_flag |= 2; break;
+ default: fprintf(pysamerr, "[bam_fillmd] unrecognized option '-%c'\n", c); return 1;
+ }
+ }
+ if (!is_sam_in) strcat(mode_r, "b");
+ if (is_bam_out) strcat(mode_w, "b");
+ else strcat(mode_w, "h");
+ if (is_uncompressed) strcat(mode_w, "u");
+ if (optind + 1 >= argc) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools fillmd [-eubrS] <aln.bam> <ref.fasta>\n\n");
+ fprintf(pysamerr, "Options: -e change identical bases to '='\n");
+ fprintf(pysamerr, " -u uncompressed BAM output (for piping)\n");
+ fprintf(pysamerr, " -b compressed BAM output\n");
+ fprintf(pysamerr, " -S the input is SAM with header\n");
+ fprintf(pysamerr, " -A modify the quality string\n");
+ fprintf(pysamerr, " -r compute the BQ tag (without -A) or cap baseQ by BAQ (with -A)\n");
+ fprintf(pysamerr, " -E extended BAQ for better sensitivity but lower specificity\n\n");
+ return 1;
+ }
+ fp = samopen(argv[optind], mode_r, 0);
+ if (fp == 0) return 1;
+ if (is_sam_in && (fp->header == 0 || fp->header->n_targets == 0)) {
+ fprintf(pysamerr, "[bam_fillmd] input SAM does not have header. Abort!\n");
+ return 1;
+ }
+ fpout = samopen("-", mode_w, fp->header);
+ fai = fai_load(argv[optind+1]);
+
+ b = bam_init1();
+ while ((ret = samread(fp, b)) >= 0) {
+ if (b->core.tid >= 0) {
+ if (tid != b->core.tid) {
+ free(ref);
+ ref = fai_fetch(fai, fp->header->target_name[b->core.tid], &len);
+ tid = b->core.tid;
+ if (ref == 0)
+ fprintf(pysamerr, "[bam_fillmd] fail to find sequence '%s' in the reference.\n",
+ fp->header->target_name[tid]);
+ }
+ if (is_realn) bam_prob_realn_core(b, ref, baq_flag);
+ if (capQ > 10) {
+ int q = bam_cap_mapQ(b, ref, capQ);
+ if (b->core.qual > q) b->core.qual = q;
+ }
+ if (ref) bam_fillmd1_core(b, ref, is_equal, max_nm);
+ }
+ samwrite(fpout, b);
+ }
+ bam_destroy1(b);
+
+ free(ref);
+ fai_destroy(fai);
+ samclose(fp); samclose(fpout);
+ return 0;
+}
+++ /dev/null
-#include <stdio.h>
-#include <stdlib.h>
-#include <ctype.h>
-#include <assert.h>
-#include "sam.h"
-
-typedef struct __linkbuf_t {
- bam1_t b;
- uint32_t beg, end;
- struct __linkbuf_t *next;
-} lbnode_t;
-
-/* --- BEGIN: Memory pool */
-
-typedef struct {
- int cnt, n, max;
- lbnode_t **buf;
-} mempool_t;
-
-static mempool_t *mp_init()
-{
- mempool_t *mp;
- mp = (mempool_t*)calloc(1, sizeof(mempool_t));
- return mp;
-}
-static void mp_destroy(mempool_t *mp)
-{
- int k;
- for (k = 0; k < mp->n; ++k) {
- free(mp->buf[k]->b.data);
- free(mp->buf[k]);
- }
- free(mp->buf);
- free(mp);
-}
-static inline lbnode_t *mp_alloc(mempool_t *mp)
-{
- ++mp->cnt;
- if (mp->n == 0) return (lbnode_t*)calloc(1, sizeof(lbnode_t));
- else return mp->buf[--mp->n];
-}
-static inline void mp_free(mempool_t *mp, lbnode_t *p)
-{
- --mp->cnt; p->next = 0; // clear lbnode_t::next here
- if (mp->n == mp->max) {
- mp->max = mp->max? mp->max<<1 : 256;
- mp->buf = (lbnode_t**)realloc(mp->buf, sizeof(lbnode_t*) * mp->max);
- }
- mp->buf[mp->n++] = p;
-}
-
-/* --- END: Memory pool */
-
-/* --- BEGIN: Auxiliary functions */
-
-static inline int resolve_cigar(bam_pileup1_t *p, uint32_t pos)
-{
- unsigned k;
- bam1_t *b = p->b;
- bam1_core_t *c = &b->core;
- uint32_t x = c->pos, y = 0;
- int ret = 1, is_restart = 1;
-
- if (c->flag&BAM_FUNMAP) return 0; // unmapped read
- assert(x <= pos); // otherwise a bug
- p->qpos = -1; p->indel = 0; p->is_del = p->is_head = p->is_tail = 0;
- for (k = 0; k < c->n_cigar; ++k) {
- int op = bam1_cigar(b)[k] & BAM_CIGAR_MASK; // operation
- int l = bam1_cigar(b)[k] >> BAM_CIGAR_SHIFT; // length
- if (op == BAM_CMATCH) { // NOTE: this assumes the first and the last operation MUST BE a match or a clip
- if (x + l > pos) { // overlap with pos
- p->indel = p->is_del = 0;
- p->qpos = y + (pos - x);
- if (x == pos && is_restart) p->is_head = 1;
- if (x + l - 1 == pos) { // come to the end of a match
- int has_next_match = 0;
- unsigned i;
- for (i = k + 1; i < c->n_cigar; ++i) {
- uint32_t cigar = bam1_cigar(b)[i];
- int opi = cigar&BAM_CIGAR_MASK;
- if (opi == BAM_CMATCH) {
- has_next_match = 1;
- break;
- } else if (opi == BAM_CSOFT_CLIP || opi == BAM_CREF_SKIP || opi == BAM_CHARD_CLIP) break;
- }
- if (!has_next_match) p->is_tail = 1;
- if (k < c->n_cigar - 1 && has_next_match) { // there are additional operation(s)
- uint32_t cigar = bam1_cigar(b)[k+1]; // next CIGAR
- int op_next = cigar&BAM_CIGAR_MASK; // next CIGAR operation
- if (op_next == BAM_CDEL) p->indel = -(int32_t)(cigar>>BAM_CIGAR_SHIFT); // del
- else if (op_next == BAM_CINS) p->indel = cigar>>BAM_CIGAR_SHIFT; // ins
- else if (op_next == BAM_CPAD && k + 2 < c->n_cigar) { // no working for adjacent padding
- cigar = bam1_cigar(b)[k+2]; op_next = cigar&BAM_CIGAR_MASK;
- if (op_next == BAM_CDEL) p->indel = -(int32_t)(cigar>>BAM_CIGAR_SHIFT); // del
- else if (op_next == BAM_CINS) p->indel = cigar>>BAM_CIGAR_SHIFT; // ins
- }
- }
- }
- }
- x += l; y += l;
- } else if (op == BAM_CDEL) { // then set ->is_del
- if (x + l > pos) {
- p->indel = 0; p->is_del = 1;
- p->qpos = y + (pos - x);
- }
- x += l;
- } else if (op == BAM_CREF_SKIP) x += l;
- else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) y += l;
- if (is_restart) is_restart ^= (op == BAM_CMATCH);
- else is_restart ^= (op == BAM_CREF_SKIP || op == BAM_CSOFT_CLIP || op == BAM_CHARD_CLIP);
- if (x > pos) {
- if (op == BAM_CREF_SKIP) ret = 0; // then do not put it into pileup at all
- break;
- }
- }
- assert(x > pos); // otherwise a bug
- return ret;
-}
-
-/* --- END: Auxiliary functions */
-
-/*******************
- * pileup iterator *
- *******************/
-
-struct __bam_plp_t {
- mempool_t *mp;
- lbnode_t *head, *tail, *dummy;
- int32_t tid, pos, max_tid, max_pos;
- int is_eof, flag_mask, max_plp, error;
- bam_pileup1_t *plp;
- // for the "auto" interface only
- bam1_t *b;
- bam_plp_auto_f func;
- void *data;
-};
-
-bam_plp_t bam_plp_init(bam_plp_auto_f func, void *data)
-{
- bam_plp_t iter;
- iter = calloc(1, sizeof(struct __bam_plp_t));
- iter->mp = mp_init();
- iter->head = iter->tail = mp_alloc(iter->mp);
- iter->dummy = mp_alloc(iter->mp);
- iter->max_tid = iter->max_pos = -1;
- iter->flag_mask = BAM_DEF_MASK;
- if (func) {
- iter->func = func;
- iter->data = data;
- iter->b = bam_init1();
- }
- return iter;
-}
-
-void bam_plp_destroy(bam_plp_t iter)
-{
- mp_free(iter->mp, iter->dummy);
- mp_free(iter->mp, iter->head);
- if (iter->mp->cnt != 0)
- fprintf(stderr, "[bam_plp_destroy] memory leak: %d. Continue anyway.\n", iter->mp->cnt);
- mp_destroy(iter->mp);
- if (iter->b) bam_destroy1(iter->b);
- free(iter->plp);
- free(iter);
-}
-
-const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
-{
- if (iter->error) { *_n_plp = -1; return 0; }
- *_n_plp = 0;
- if (iter->is_eof && iter->head->next == 0) return 0;
- while (iter->is_eof || iter->max_tid > iter->tid || (iter->max_tid == iter->tid && iter->max_pos > iter->pos)) {
- int n_plp = 0;
- lbnode_t *p, *q;
- // write iter->plp at iter->pos
- iter->dummy->next = iter->head;
- for (p = iter->head, q = iter->dummy; p->next; q = p, p = p->next) {
- if (p->b.core.tid < iter->tid || (p->b.core.tid == iter->tid && p->end <= iter->pos)) { // then remove
- q->next = p->next; mp_free(iter->mp, p); p = q;
- } else if (p->b.core.tid == iter->tid && p->beg <= iter->pos) { // here: p->end > pos; then add to pileup
- if (n_plp == iter->max_plp) { // then double the capacity
- iter->max_plp = iter->max_plp? iter->max_plp<<1 : 256;
- iter->plp = (bam_pileup1_t*)realloc(iter->plp, sizeof(bam_pileup1_t) * iter->max_plp);
- }
- iter->plp[n_plp].b = &p->b;
- if (resolve_cigar(iter->plp + n_plp, iter->pos)) ++n_plp; // skip the read if we are looking at ref-skip
- }
- }
- iter->head = iter->dummy->next; // dummy->next may be changed
- *_n_plp = n_plp; *_tid = iter->tid; *_pos = iter->pos;
- // update iter->tid and iter->pos
- if (iter->head->next) {
- if (iter->tid > iter->head->b.core.tid) {
- fprintf(stderr, "[%s] unsorted input. Pileup aborts.\n", __func__);
- iter->error = 1;
- *_n_plp = -1;
- return 0;
- }
- }
- if (iter->tid < iter->head->b.core.tid) { // come to a new reference sequence
- iter->tid = iter->head->b.core.tid; iter->pos = iter->head->beg; // jump to the next reference
- } else if (iter->pos < iter->head->beg) { // here: tid == head->b.core.tid
- iter->pos = iter->head->beg; // jump to the next position
- } else ++iter->pos; // scan contiguously
- // return
- if (n_plp) return iter->plp;
- if (iter->is_eof && iter->head->next == 0) break;
- }
- return 0;
-}
-
-int bam_plp_push(bam_plp_t iter, const bam1_t *b)
-{
- if (iter->error) return -1;
- if (b) {
- if (b->core.tid < 0) return 0;
- if (b->core.flag & iter->flag_mask) return 0;
- bam_copy1(&iter->tail->b, b);
- iter->tail->beg = b->core.pos; iter->tail->end = bam_calend(&b->core, bam1_cigar(b));
- if (b->core.tid < iter->max_tid) {
- fprintf(stderr, "[bam_pileup_core] the input is not sorted (chromosomes out of order)\n");
- iter->error = 1;
- return -1;
- }
- if ((b->core.tid == iter->max_tid) && (iter->tail->beg < iter->max_pos)) {
- fprintf(stderr, "[bam_pileup_core] the input is not sorted (reads out of order)\n");
- iter->error = 1;
- return -1;
- }
- iter->max_tid = b->core.tid; iter->max_pos = iter->tail->beg;
- if (iter->tail->end > iter->pos || iter->tail->b.core.tid > iter->tid) {
- iter->tail->next = mp_alloc(iter->mp);
- iter->tail = iter->tail->next;
- }
- } else iter->is_eof = 1;
- return 0;
-}
-
-const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
-{
- const bam_pileup1_t *plp;
- if (iter->func == 0 || iter->error) { *_n_plp = -1; return 0; }
- if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
- else {
- *_n_plp = 0;
- if (iter->is_eof) return 0;
- while (iter->func(iter->data, iter->b) >= 0) {
- if (bam_plp_push(iter, iter->b) < 0) {
- *_n_plp = -1;
- return 0;
- }
- if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
- }
- bam_plp_push(iter, 0);
- if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
- return 0;
- }
-}
-
-void bam_plp_reset(bam_plp_t iter)
-{
- lbnode_t *p, *q;
- iter->max_tid = iter->max_pos = -1;
- iter->tid = iter->pos = 0;
- iter->is_eof = 0;
- for (p = iter->head; p->next;) {
- q = p->next;
- mp_free(iter->mp, p);
- p = q;
- }
- iter->head = iter->tail;
-}
-
-void bam_plp_set_mask(bam_plp_t iter, int mask)
-{
- iter->flag_mask = mask < 0? BAM_DEF_MASK : (BAM_FUNMAP | mask);
-}
-
-/*****************
- * callback APIs *
- *****************/
-
-int bam_pileup_file(bamFile fp, int mask, bam_pileup_f func, void *func_data)
-{
- bam_plbuf_t *buf;
- int ret;
- bam1_t *b;
- b = bam_init1();
- buf = bam_plbuf_init(func, func_data);
- bam_plbuf_set_mask(buf, mask);
- while ((ret = bam_read1(fp, b)) >= 0)
- bam_plbuf_push(b, buf);
- bam_plbuf_push(0, buf);
- bam_plbuf_destroy(buf);
- bam_destroy1(b);
- return 0;
-}
-
-void bam_plbuf_set_mask(bam_plbuf_t *buf, int mask)
-{
- bam_plp_set_mask(buf->iter, mask);
-}
-
-void bam_plbuf_reset(bam_plbuf_t *buf)
-{
- bam_plp_reset(buf->iter);
-}
-
-bam_plbuf_t *bam_plbuf_init(bam_pileup_f func, void *data)
-{
- bam_plbuf_t *buf;
- buf = calloc(1, sizeof(bam_plbuf_t));
- buf->iter = bam_plp_init(0, 0);
- buf->func = func;
- buf->data = data;
- return buf;
-}
-
-void bam_plbuf_destroy(bam_plbuf_t *buf)
-{
- bam_plp_destroy(buf->iter);
- free(buf);
-}
-
-int bam_plbuf_push(const bam1_t *b, bam_plbuf_t *buf)
-{
- int ret, n_plp, tid, pos;
- const bam_pileup1_t *plp;
- ret = bam_plp_push(buf->iter, b);
- if (ret < 0) return ret;
- while ((plp = bam_plp_next(buf->iter, &tid, &pos, &n_plp)) != 0)
- buf->func(tid, pos, n_plp, plp, buf->data);
- return 0;
-}
-
-/***********
- * mpileup *
- ***********/
-
-struct __bam_mplp_t {
- int n;
- uint64_t min, *pos;
- bam_plp_t *iter;
- int *n_plp;
- const bam_pileup1_t **plp;
-};
-
-bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data)
-{
- int i;
- bam_mplp_t iter;
- iter = calloc(1, sizeof(struct __bam_mplp_t));
- iter->pos = calloc(n, 8);
- iter->n_plp = calloc(n, sizeof(int));
- iter->plp = calloc(n, sizeof(void*));
- iter->iter = calloc(n, sizeof(void*));
- iter->n = n;
- iter->min = (uint64_t)-1;
- for (i = 0; i < n; ++i) {
- iter->iter[i] = bam_plp_init(func, data[i]);
- iter->pos[i] = iter->min;
- }
- return iter;
-}
-
-void bam_mplp_destroy(bam_mplp_t iter)
-{
- int i;
- for (i = 0; i < iter->n; ++i) bam_plp_destroy(iter->iter[i]);
- free(iter->iter); free(iter->pos); free(iter->n_plp); free(iter->plp);
- free(iter);
-}
-
-int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp)
-{
- int i, ret = 0;
- uint64_t new_min = (uint64_t)-1;
- for (i = 0; i < iter->n; ++i) {
- if (iter->pos[i] == iter->min) {
- int tid, pos;
- iter->plp[i] = bam_plp_auto(iter->iter[i], &tid, &pos, &iter->n_plp[i]);
- iter->pos[i] = (uint64_t)tid<<32 | pos;
- }
- if (iter->plp[i] && iter->pos[i] < new_min) new_min = iter->pos[i];
- }
- iter->min = new_min;
- if (new_min == (uint64_t)-1) return 0;
- *_tid = new_min>>32; *_pos = (uint32_t)new_min;
- for (i = 0; i < iter->n; ++i) {
- if (iter->pos[i] == iter->min) {
- n_plp[i] = iter->n_plp[i], plp[i] = iter->plp[i];
- ++ret;
- } else n_plp[i] = 0, plp[i] = 0;
- }
- return ret;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <ctype.h>
+#include <assert.h>
+#include "sam.h"
+
+typedef struct {
+ int k, x, y, end;
+} cstate_t;
+
+static cstate_t g_cstate_null = { -1, 0, 0, 0 };
+
+typedef struct __linkbuf_t {
+ bam1_t b;
+ uint32_t beg, end;
+ cstate_t s;
+ struct __linkbuf_t *next;
+} lbnode_t;
+
+/* --- BEGIN: Memory pool */
+
+typedef struct {
+ int cnt, n, max;
+ lbnode_t **buf;
+} mempool_t;
+
+static mempool_t *mp_init()
+{
+ mempool_t *mp;
+ mp = (mempool_t*)calloc(1, sizeof(mempool_t));
+ return mp;
+}
+static void mp_destroy(mempool_t *mp)
+{
+ int k;
+ for (k = 0; k < mp->n; ++k) {
+ free(mp->buf[k]->b.data);
+ free(mp->buf[k]);
+ }
+ free(mp->buf);
+ free(mp);
+}
+static inline lbnode_t *mp_alloc(mempool_t *mp)
+{
+ ++mp->cnt;
+ if (mp->n == 0) return (lbnode_t*)calloc(1, sizeof(lbnode_t));
+ else return mp->buf[--mp->n];
+}
+static inline void mp_free(mempool_t *mp, lbnode_t *p)
+{
+ --mp->cnt; p->next = 0; // clear lbnode_t::next here
+ if (mp->n == mp->max) {
+ mp->max = mp->max? mp->max<<1 : 256;
+ mp->buf = (lbnode_t**)realloc(mp->buf, sizeof(lbnode_t*) * mp->max);
+ }
+ mp->buf[mp->n++] = p;
+}
+
+/* --- END: Memory pool */
+
+/* --- BEGIN: Auxiliary functions */
+
+/* s->k: the index of the CIGAR operator that has just been processed.
+ s->x: the reference coordinate of the start of s->k
+ s->y: the query coordiante of the start of s->k
+ */
+static inline int resolve_cigar2(bam_pileup1_t *p, uint32_t pos, cstate_t *s)
+{
+#define _cop(c) ((c)&BAM_CIGAR_MASK)
+#define _cln(c) ((c)>>BAM_CIGAR_SHIFT)
+
+ bam1_t *b = p->b;
+ bam1_core_t *c = &b->core;
+ uint32_t *cigar = bam1_cigar(b);
+ int k, is_head = 0;
+ // determine the current CIGAR operation
+// fprintf(pysamerr, "%s\tpos=%d\tend=%d\t(%d,%d,%d)\n", bam1_qname(b), pos, s->end, s->k, s->x, s->y);
+ if (s->k == -1) { // never processed
+ is_head = 1;
+ if (c->n_cigar == 1) { // just one operation, save a loop
+ if (_cop(cigar[0]) == BAM_CMATCH) s->k = 0, s->x = c->pos, s->y = 0;
+ } else { // find the first match or deletion
+ for (k = 0, s->x = c->pos, s->y = 0; k < c->n_cigar; ++k) {
+ int op = _cop(cigar[k]);
+ int l = _cln(cigar[k]);
+ if (op == BAM_CMATCH || op == BAM_CDEL) break;
+ else if (op == BAM_CREF_SKIP) s->x += l;
+ else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) s->y += l;
+ }
+ assert(k < c->n_cigar);
+ s->k = k;
+ }
+ } else { // the read has been processed before
+ int op, l = _cln(cigar[s->k]);
+ if (pos - s->x >= l) { // jump to the next operation
+ assert(s->k < c->n_cigar); // otherwise a bug: this function should not be called in this case
+ op = _cop(cigar[s->k+1]);
+ if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP) { // jump to the next without a loop
+ if (_cop(cigar[s->k]) == BAM_CMATCH) s->y += l;
+ s->x += l;
+ ++s->k;
+ } else { // find the next M/D/N
+ if (_cop(cigar[s->k]) == BAM_CMATCH) s->y += l;
+ s->x += l;
+ for (k = s->k + 1; k < c->n_cigar; ++k) {
+ op = _cop(cigar[k]), l = _cln(cigar[k]);
+ if (op == BAM_CMATCH || op == BAM_CDEL || op == BAM_CREF_SKIP) break;
+ else if (op == BAM_CINS || op == BAM_CSOFT_CLIP) s->y += l;
+ }
+ s->k = k;
+ }
+ assert(s->k < c->n_cigar); // otherwise a bug
+ } // else, do nothing
+ }
+ { // collect pileup information
+ int op, l;
+ op = _cop(cigar[s->k]); l = _cln(cigar[s->k]);
+ p->is_del = p->indel = p->is_refskip = 0;
+ if (s->x + l - 1 == pos && s->k + 1 < c->n_cigar) { // peek the next operation
+ int op2 = _cop(cigar[s->k+1]);
+ int l2 = _cln(cigar[s->k+1]);
+ if (op2 == BAM_CDEL) p->indel = -(int)l2;
+ else if (op2 == BAM_CINS) p->indel = l2;
+ else if (op2 == BAM_CPAD && s->k + 2 < c->n_cigar) { // no working for adjacent padding
+ int l3 = 0;
+ for (k = s->k + 2; k < c->n_cigar; ++k) {
+ op2 = _cop(cigar[k]); l2 = _cln(cigar[k]);
+ if (op2 == BAM_CINS) l3 += l2;
+ else if (op2 == BAM_CDEL || op2 == BAM_CMATCH || op2 == BAM_CREF_SKIP) break;
+ }
+ if (l3 > 0) p->indel = l3;
+ }
+ }
+ if (op == BAM_CMATCH) {
+ p->qpos = s->y + (pos - s->x);
+ } else if (op == BAM_CDEL || op == BAM_CREF_SKIP) {
+ p->is_del = 1; p->qpos = s->y; // FIXME: distinguish D and N!!!!!
+ p->is_refskip = (op == BAM_CREF_SKIP);
+ } // cannot be other operations; otherwise a bug
+ p->is_head = (pos == c->pos); p->is_tail = (pos == s->end);
+ }
+ return 1;
+}
+
+/* --- END: Auxiliary functions */
+
+/*******************
+ * pileup iterator *
+ *******************/
+
+struct __bam_plp_t {
+ mempool_t *mp;
+ lbnode_t *head, *tail, *dummy;
+ int32_t tid, pos, max_tid, max_pos;
+ int is_eof, flag_mask, max_plp, error, maxcnt;
+ bam_pileup1_t *plp;
+ // for the "auto" interface only
+ bam1_t *b;
+ bam_plp_auto_f func;
+ void *data;
+};
+
+bam_plp_t bam_plp_init(bam_plp_auto_f func, void *data)
+{
+ bam_plp_t iter;
+ iter = calloc(1, sizeof(struct __bam_plp_t));
+ iter->mp = mp_init();
+ iter->head = iter->tail = mp_alloc(iter->mp);
+ iter->dummy = mp_alloc(iter->mp);
+ iter->max_tid = iter->max_pos = -1;
+ iter->flag_mask = BAM_DEF_MASK;
+ iter->maxcnt = 8000;
+ if (func) {
+ iter->func = func;
+ iter->data = data;
+ iter->b = bam_init1();
+ }
+ return iter;
+}
+
+void bam_plp_destroy(bam_plp_t iter)
+{
+ mp_free(iter->mp, iter->dummy);
+ mp_free(iter->mp, iter->head);
+ if (iter->mp->cnt != 0)
+ fprintf(pysamerr, "[bam_plp_destroy] memory leak: %d. Continue anyway.\n", iter->mp->cnt);
+ mp_destroy(iter->mp);
+ if (iter->b) bam_destroy1(iter->b);
+ free(iter->plp);
+ free(iter);
+}
+
+const bam_pileup1_t *bam_plp_next(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
+{
+ if (iter->error) { *_n_plp = -1; return 0; }
+ *_n_plp = 0;
+ if (iter->is_eof && iter->head->next == 0) return 0;
+ while (iter->is_eof || iter->max_tid > iter->tid || (iter->max_tid == iter->tid && iter->max_pos > iter->pos)) {
+ int n_plp = 0;
+ lbnode_t *p, *q;
+ // write iter->plp at iter->pos
+ iter->dummy->next = iter->head;
+ for (p = iter->head, q = iter->dummy; p->next; q = p, p = p->next) {
+ if (p->b.core.tid < iter->tid || (p->b.core.tid == iter->tid && p->end <= iter->pos)) { // then remove
+ q->next = p->next; mp_free(iter->mp, p); p = q;
+ } else if (p->b.core.tid == iter->tid && p->beg <= iter->pos) { // here: p->end > pos; then add to pileup
+ if (n_plp == iter->max_plp) { // then double the capacity
+ iter->max_plp = iter->max_plp? iter->max_plp<<1 : 256;
+ iter->plp = (bam_pileup1_t*)realloc(iter->plp, sizeof(bam_pileup1_t) * iter->max_plp);
+ }
+ iter->plp[n_plp].b = &p->b;
+ if (resolve_cigar2(iter->plp + n_plp, iter->pos, &p->s)) ++n_plp; // actually always true...
+ }
+ }
+ iter->head = iter->dummy->next; // dummy->next may be changed
+ *_n_plp = n_plp; *_tid = iter->tid; *_pos = iter->pos;
+ // update iter->tid and iter->pos
+ if (iter->head->next) {
+ if (iter->tid > iter->head->b.core.tid) {
+ fprintf(pysamerr, "[%s] unsorted input. Pileup aborts.\n", __func__);
+ iter->error = 1;
+ *_n_plp = -1;
+ return 0;
+ }
+ }
+ if (iter->tid < iter->head->b.core.tid) { // come to a new reference sequence
+ iter->tid = iter->head->b.core.tid; iter->pos = iter->head->beg; // jump to the next reference
+ } else if (iter->pos < iter->head->beg) { // here: tid == head->b.core.tid
+ iter->pos = iter->head->beg; // jump to the next position
+ } else ++iter->pos; // scan contiguously
+ // return
+ if (n_plp) return iter->plp;
+ if (iter->is_eof && iter->head->next == 0) break;
+ }
+ return 0;
+}
+
+int bam_plp_push(bam_plp_t iter, const bam1_t *b)
+{
+ if (iter->error) return -1;
+ if (b) {
+ if (b->core.tid < 0) return 0;
+ if (b->core.flag & iter->flag_mask) return 0;
+ if (iter->tid == b->core.tid && iter->pos == b->core.pos && iter->mp->cnt > iter->maxcnt) return 0;
+ bam_copy1(&iter->tail->b, b);
+ iter->tail->beg = b->core.pos; iter->tail->end = bam_calend(&b->core, bam1_cigar(b));
+ iter->tail->s = g_cstate_null; iter->tail->s.end = iter->tail->end - 1; // initialize cstate_t
+ if (b->core.tid < iter->max_tid) {
+ fprintf(pysamerr, "[bam_pileup_core] the input is not sorted (chromosomes out of order)\n");
+ iter->error = 1;
+ return -1;
+ }
+ if ((b->core.tid == iter->max_tid) && (iter->tail->beg < iter->max_pos)) {
+ fprintf(pysamerr, "[bam_pileup_core] the input is not sorted (reads out of order)\n");
+ iter->error = 1;
+ return -1;
+ }
+ iter->max_tid = b->core.tid; iter->max_pos = iter->tail->beg;
+ if (iter->tail->end > iter->pos || iter->tail->b.core.tid > iter->tid) {
+ iter->tail->next = mp_alloc(iter->mp);
+ iter->tail = iter->tail->next;
+ }
+ } else iter->is_eof = 1;
+ return 0;
+}
+
+const bam_pileup1_t *bam_plp_auto(bam_plp_t iter, int *_tid, int *_pos, int *_n_plp)
+{
+ const bam_pileup1_t *plp;
+ if (iter->func == 0 || iter->error) { *_n_plp = -1; return 0; }
+ if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
+ else { // no pileup line can be obtained; read alignments
+ *_n_plp = 0;
+ if (iter->is_eof) return 0;
+ while (iter->func(iter->data, iter->b) >= 0) {
+ if (bam_plp_push(iter, iter->b) < 0) {
+ *_n_plp = -1;
+ return 0;
+ }
+ if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
+ // otherwise no pileup line can be returned; read the next alignment.
+ }
+ bam_plp_push(iter, 0);
+ if ((plp = bam_plp_next(iter, _tid, _pos, _n_plp)) != 0) return plp;
+ return 0;
+ }
+}
+
+void bam_plp_reset(bam_plp_t iter)
+{
+ lbnode_t *p, *q;
+ iter->max_tid = iter->max_pos = -1;
+ iter->tid = iter->pos = 0;
+ iter->is_eof = 0;
+ for (p = iter->head; p->next;) {
+ q = p->next;
+ mp_free(iter->mp, p);
+ p = q;
+ }
+ iter->head = iter->tail;
+}
+
+void bam_plp_set_mask(bam_plp_t iter, int mask)
+{
+ iter->flag_mask = mask < 0? BAM_DEF_MASK : (BAM_FUNMAP | mask);
+}
+
+void bam_plp_set_maxcnt(bam_plp_t iter, int maxcnt)
+{
+ iter->maxcnt = maxcnt;
+}
+
+/*****************
+ * callback APIs *
+ *****************/
+
+int bam_pileup_file(bamFile fp, int mask, bam_pileup_f func, void *func_data)
+{
+ bam_plbuf_t *buf;
+ int ret;
+ bam1_t *b;
+ b = bam_init1();
+ buf = bam_plbuf_init(func, func_data);
+ bam_plbuf_set_mask(buf, mask);
+ while ((ret = bam_read1(fp, b)) >= 0)
+ bam_plbuf_push(b, buf);
+ bam_plbuf_push(0, buf);
+ bam_plbuf_destroy(buf);
+ bam_destroy1(b);
+ return 0;
+}
+
+void bam_plbuf_set_mask(bam_plbuf_t *buf, int mask)
+{
+ bam_plp_set_mask(buf->iter, mask);
+}
+
+void bam_plbuf_reset(bam_plbuf_t *buf)
+{
+ bam_plp_reset(buf->iter);
+}
+
+bam_plbuf_t *bam_plbuf_init(bam_pileup_f func, void *data)
+{
+ bam_plbuf_t *buf;
+ buf = calloc(1, sizeof(bam_plbuf_t));
+ buf->iter = bam_plp_init(0, 0);
+ buf->func = func;
+ buf->data = data;
+ return buf;
+}
+
+void bam_plbuf_destroy(bam_plbuf_t *buf)
+{
+ bam_plp_destroy(buf->iter);
+ free(buf);
+}
+
+int bam_plbuf_push(const bam1_t *b, bam_plbuf_t *buf)
+{
+ int ret, n_plp, tid, pos;
+ const bam_pileup1_t *plp;
+ ret = bam_plp_push(buf->iter, b);
+ if (ret < 0) return ret;
+ while ((plp = bam_plp_next(buf->iter, &tid, &pos, &n_plp)) != 0)
+ buf->func(tid, pos, n_plp, plp, buf->data);
+ return 0;
+}
+
+/***********
+ * mpileup *
+ ***********/
+
+struct __bam_mplp_t {
+ int n;
+ uint64_t min, *pos;
+ bam_plp_t *iter;
+ int *n_plp;
+ const bam_pileup1_t **plp;
+};
+
+bam_mplp_t bam_mplp_init(int n, bam_plp_auto_f func, void **data)
+{
+ int i;
+ bam_mplp_t iter;
+ iter = calloc(1, sizeof(struct __bam_mplp_t));
+ iter->pos = calloc(n, 8);
+ iter->n_plp = calloc(n, sizeof(int));
+ iter->plp = calloc(n, sizeof(void*));
+ iter->iter = calloc(n, sizeof(void*));
+ iter->n = n;
+ iter->min = (uint64_t)-1;
+ for (i = 0; i < n; ++i) {
+ iter->iter[i] = bam_plp_init(func, data[i]);
+ iter->pos[i] = iter->min;
+ }
+ return iter;
+}
+
+void bam_mplp_set_maxcnt(bam_mplp_t iter, int maxcnt)
+{
+ int i;
+ for (i = 0; i < iter->n; ++i)
+ iter->iter[i]->maxcnt = maxcnt;
+}
+
+void bam_mplp_destroy(bam_mplp_t iter)
+{
+ int i;
+ for (i = 0; i < iter->n; ++i) bam_plp_destroy(iter->iter[i]);
+ free(iter->iter); free(iter->pos); free(iter->n_plp); free(iter->plp);
+ free(iter);
+}
+
+int bam_mplp_auto(bam_mplp_t iter, int *_tid, int *_pos, int *n_plp, const bam_pileup1_t **plp)
+{
+ int i, ret = 0;
+ uint64_t new_min = (uint64_t)-1;
+ for (i = 0; i < iter->n; ++i) {
+ if (iter->pos[i] == iter->min) {
+ int tid, pos;
+ iter->plp[i] = bam_plp_auto(iter->iter[i], &tid, &pos, &iter->n_plp[i]);
+ iter->pos[i] = (uint64_t)tid<<32 | pos;
+ }
+ if (iter->plp[i] && iter->pos[i] < new_min) new_min = iter->pos[i];
+ }
+ iter->min = new_min;
+ if (new_min == (uint64_t)-1) return 0;
+ *_tid = new_min>>32; *_pos = (uint32_t)new_min;
+ for (i = 0; i < iter->n; ++i) {
+ if (iter->pos[i] == iter->min) { // FIXME: valgrind reports "uninitialised value(s) at this line"
+ n_plp[i] = iter->n_plp[i], plp[i] = iter->plp[i];
+ ++ret;
+ } else n_plp[i] = 0, plp[i] = 0;
+ }
+ return ret;
+}
+++ /dev/null
-#include <math.h>
-#include <stdio.h>
-#include <unistd.h>
-#include <ctype.h>
-#include "sam.h"
-#include "faidx.h"
-#include "bam_maqcns.h"
-#include "khash.h"
-#include "glf.h"
-#include "kstring.h"
-
-typedef int *indel_list_t;
-KHASH_MAP_INIT_INT64(64, indel_list_t)
-
-#define BAM_PLF_SIMPLE 0x01
-#define BAM_PLF_CNS 0x02
-#define BAM_PLF_INDEL_ONLY 0x04
-#define BAM_PLF_GLF 0x08
-#define BAM_PLF_VAR_ONLY 0x10
-#define BAM_PLF_2ND 0x20
-#define BAM_PLF_RANBASE 0x40
-#define BAM_PLF_1STBASE 0x80
-#define BAM_PLF_ALLBASE 0x100
-#define BAM_PLF_READPOS 0x200
-
-typedef struct {
- bam_header_t *h;
- bam_maqcns_t *c;
- bam_maqindel_opt_t *ido;
- faidx_t *fai;
- khash_t(64) *hash;
- uint32_t format;
- int tid, len, last_pos;
- int mask;
- int max_depth; // for indel calling, ignore reads with the depth too high. 0 for unlimited
- char *ref;
- glfFile fp_glf; // for glf output only
-} pu_data_t;
-
-char **__bam_get_lines(const char *fn, int *_n);
-void bam_init_header_hash(bam_header_t *header);
-int32_t bam_get_tid(const bam_header_t *header, const char *seq_name);
-
-static khash_t(64) *load_pos(const char *fn, bam_header_t *h)
-{
- char **list;
- int i, j, n, *fields, max_fields;
- khash_t(64) *hash;
- bam_init_header_hash(h);
- list = __bam_get_lines(fn, &n);
- hash = kh_init(64);
- max_fields = 0; fields = 0;
- for (i = 0; i < n; ++i) {
- char *str = list[i];
- int chr, n_fields, ret;
- khint_t k;
- uint64_t x;
- n_fields = ksplit_core(str, 0, &max_fields, &fields);
- if (n_fields < 2) continue;
- chr = bam_get_tid(h, str + fields[0]);
- if (chr < 0) {
- fprintf(stderr, "[load_pos] unknown reference sequence name: %s\n", str + fields[0]);
- continue;
- }
- x = (uint64_t)chr << 32 | (atoi(str + fields[1]) - 1);
- k = kh_put(64, hash, x, &ret);
- if (ret == 0) {
- fprintf(stderr, "[load_pos] position %s:%s has been loaded.\n", str+fields[0], str+fields[1]);
- continue;
- }
- kh_val(hash, k) = 0;
- if (n_fields > 2) {
- // count
- for (j = 2; j < n_fields; ++j) {
- char *s = str + fields[j];
- if ((*s != '+' && *s != '-') || !isdigit(s[1])) break;
- }
- if (j > 2) { // update kh_val()
- int *q, y, z;
- q = kh_val(hash, k) = (int*)calloc(j - 1, sizeof(int));
- q[0] = j - 2; z = j; y = 1;
- for (j = 2; j < z; ++j)
- q[y++] = atoi(str + fields[j]);
- }
- }
- free(str);
- }
- free(list); free(fields);
- return hash;
-}
-
-// an analogy to pileup_func() below
-static int glt3_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pu, void *data)
-{
- pu_data_t *d = (pu_data_t*)data;
- bam_maqindel_ret_t *r = 0;
- int rb, *proposed_indels = 0;
- glf1_t *g;
- glf3_t *g3;
-
- if (d->fai == 0) {
- fprintf(stderr, "[glt3_func] reference sequence is required for generating GLT. Abort!\n");
- exit(1);
- }
- if (d->hash) { // only output a list of sites
- khint_t k = kh_get(64, d->hash, (uint64_t)tid<<32|pos);
- if (k == kh_end(d->hash)) return 0;
- proposed_indels = kh_val(d->hash, k);
- }
- g3 = glf3_init1();
- if (d->fai && (int)tid != d->tid) {
- if (d->ref) { // then write the end mark
- g3->rtype = GLF3_RTYPE_END;
- glf3_write1(d->fp_glf, g3);
- }
- glf3_ref_write(d->fp_glf, d->h->target_name[tid], d->h->target_len[tid]); // write reference
- free(d->ref);
- d->ref = fai_fetch(d->fai, d->h->target_name[tid], &d->len);
- d->tid = tid;
- d->last_pos = 0;
- }
- rb = (d->ref && (int)pos < d->len)? d->ref[pos] : 'N';
- g = bam_maqcns_glfgen(n, pu, bam_nt16_table[rb], d->c);
- memcpy(g3, g, sizeof(glf1_t));
- g3->rtype = GLF3_RTYPE_SUB;
- g3->offset = pos - d->last_pos;
- d->last_pos = pos;
- glf3_write1(d->fp_glf, g3);
- if (pos < d->len) {
- int m = (!d->max_depth || d->max_depth>n) ? n : d->max_depth;
- if (proposed_indels)
- r = bam_maqindel(m, pos, d->ido, pu, d->ref, proposed_indels[0], proposed_indels+1);
- else r = bam_maqindel(m, pos, d->ido, pu, d->ref, 0, 0);
- }
- if (r) { // then write indel line
- int het = 3 * n, min;
- min = het;
- if (min > r->gl[0]) min = r->gl[0];
- if (min > r->gl[1]) min = r->gl[1];
- g3->ref_base = 0;
- g3->rtype = GLF3_RTYPE_INDEL;
- memset(g3->lk, 0, 10);
- g3->lk[0] = r->gl[0] - min < 255? r->gl[0] - min : 255;
- g3->lk[1] = r->gl[1] - min < 255? r->gl[1] - min : 255;
- g3->lk[2] = het - min < 255? het - min : 255;
- g3->offset = 0;
- g3->indel_len[0] = r->indel1;
- g3->indel_len[1] = r->indel2;
- g3->min_lk = min < 255? min : 255;
- g3->max_len = (abs(r->indel1) > abs(r->indel2)? abs(r->indel1) : abs(r->indel2)) + 1;
- g3->indel_seq[0] = strdup(r->s[0]+1);
- g3->indel_seq[1] = strdup(r->s[1]+1);
- glf3_write1(d->fp_glf, g3);
- bam_maqindel_ret_destroy(r);
- }
- free(g);
- glf3_destroy1(g3);
- return 0;
-}
-
-static void pileup_seq(const bam_pileup1_t *p, int pos, int ref_len, const char *ref)
-{
- if (p->is_head) printf("^%c", p->b->core.qual > 93? 126 : p->b->core.qual + 33);
- if (!p->is_del) {
- int j, rb, c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos)];
- rb = (ref && pos < ref_len)? ref[pos] : 'N';
- if (c == '=' || toupper(c) == toupper(rb)) c = bam1_strand(p->b)? ',' : '.';
- else c = bam1_strand(p->b)? tolower(c) : toupper(c);
- putchar(c);
- if (p->indel > 0) {
- printf("+%d", p->indel);
- for (j = 1; j <= p->indel; ++j) {
- c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos + j)];
- putchar(bam1_strand(p->b)? tolower(c) : toupper(c));
- }
- } else if (p->indel < 0) {
- printf("%d", p->indel);
- for (j = 1; j <= -p->indel; ++j) {
- c = (ref && (int)pos+j < ref_len)? ref[pos+j] : 'N';
- putchar(bam1_strand(p->b)? tolower(c) : toupper(c));
- }
- }
- } else putchar('*');
- if (p->is_tail) putchar('$');
-}
-
-static int pileup_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pu, void *data)
-{
- pu_data_t *d = (pu_data_t*)data;
- bam_maqindel_ret_t *r = 0;
- int i, rb, rms_mapq = -1, *proposed_indels = 0;
- uint64_t rms_aux;
- uint32_t cns = 0;
-
- // if GLF is required, suppress -c completely
- if (d->format & BAM_PLF_GLF) return glt3_func(tid, pos, n, pu, data);
- // if d->hash is initialized, only output the sites in the hash table
- if (d->hash) {
- khint_t k = kh_get(64, d->hash, (uint64_t)tid<<32|pos);
- if (k == kh_end(d->hash)) return 0;
- proposed_indels = kh_val(d->hash, k);
- }
- // update d->ref if necessary
- if (d->fai && (int)tid != d->tid) {
- free(d->ref);
- d->ref = faidx_fetch_seq(d->fai, d->h->target_name[tid], 0, 0x7fffffff, &d->len);
- d->tid = tid;
- }
- rb = (d->ref && (int)pos < d->len)? d->ref[pos] : 'N';
- // when the indel-only mode is asked for, return if no reads mapped with indels
- if (d->format & BAM_PLF_INDEL_ONLY) {
- for (i = 0; i < n; ++i)
- if (pu[i].indel != 0) break;
- if (i == n) return 0;
- }
- // call the consensus and indel
- if (d->format & BAM_PLF_CNS) { // call consensus
- if (d->format & (BAM_PLF_RANBASE|BAM_PLF_1STBASE)) { // use a random base or the 1st base as the consensus call
- const bam_pileup1_t *p = (d->format & BAM_PLF_1STBASE)? pu : pu + (int)(drand48() * n);
- int q = bam1_qual(p->b)[p->qpos];
- int mapQ = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
- uint32_t b = bam1_seqi(bam1_seq(p->b), p->qpos);
- cns = b<<28 | 0xf<<24 | mapQ<<16 | q<<8;
- } else if (d->format & BAM_PLF_ALLBASE) { // collapse all bases
- uint64_t rmsQ = 0;
- uint32_t b = 0;
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pu + i;
- int q = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
- b |= bam1_seqi(bam1_seq(p->b), p->qpos);
- rmsQ += q * q;
- }
- rmsQ = (uint64_t)(sqrt((double)rmsQ / n) + .499);
- cns = b<<28 | 0xf<<24 | rmsQ<<16 | 60<<8;
- } else cns = bam_maqcns_call(n, pu, d->c);
- }
- if ((d->format & (BAM_PLF_CNS|BAM_PLF_INDEL_ONLY)) && d->ref && pos < d->len) { // call indels
- int m = (!d->max_depth || d->max_depth>n) ? n : d->max_depth;
- if (proposed_indels) // the first element gives the size of the array
- r = bam_maqindel(m, pos, d->ido, pu, d->ref, proposed_indels[0], proposed_indels+1);
- else r = bam_maqindel(m, pos, d->ido, pu, d->ref, 0, 0);
- }
- // when only variant sites are asked for, test if the site is a variant
- if ((d->format & BAM_PLF_CNS) && (d->format & BAM_PLF_VAR_ONLY)) {
- if (!(bam_nt16_table[rb] != 15 && cns>>28 != bam_nt16_table[rb])) { // not a SNP
- if (!(r && (r->gt == 2 || strcmp(r->s[r->gt], "*")))) { // not an indel
- if (r) bam_maqindel_ret_destroy(r);
- return 0;
- }
- }
- }
- // print the first 3 columns
- printf("%s\t%d\t%c\t", d->h->target_name[tid], pos + 1, rb);
- // print consensus information if required
- if (d->format & BAM_PLF_CNS) {
- int ref_q, rb4 = bam_nt16_table[rb];
- ref_q = 0;
- if (rb4 != 15 && cns>>28 != 15 && cns>>28 != rb4) { // a SNP
- ref_q = ((cns>>24&0xf) == rb4)? cns>>8&0xff : (cns>>8&0xff) + (cns&0xff);
- if (ref_q > 255) ref_q = 255;
- }
- rms_mapq = cns>>16&0xff;
- printf("%c\t%d\t%d\t%d\t", bam_nt16_rev_table[cns>>28], cns>>8&0xff, ref_q, rms_mapq);
- }
- // print pileup sequences
- printf("%d\t", n);
- rms_aux = 0; // we need to recalculate rms_mapq when -c is not flagged on the command line
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pu + i;
- int tmp = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
- rms_aux += tmp * tmp;
- pileup_seq(p, pos, d->len, d->ref);
- }
- // finalize rms_mapq
- rms_aux = (uint64_t)(sqrt((double)rms_aux / n) + .499);
- if (rms_mapq < 0) rms_mapq = rms_aux;
- putchar('\t');
- // print quality
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pu + i;
- int c = bam1_qual(p->b)[p->qpos] + 33;
- if (c > 126) c = 126;
- putchar(c);
- }
- if (d->format & BAM_PLF_2ND) { // print 2nd calls and qualities
- const unsigned char *q;
- putchar('\t');
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pu + i;
- q = bam_aux_get(p->b, "E2");
- putchar(q? q[p->qpos + 1] : 'N');
- }
- putchar('\t');
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pu + i;
- q = bam_aux_get(p->b, "U2");
- putchar(q? q[p->qpos + 1] : '!');
- }
- }
- // print mapping quality if -s is flagged on the command line
- if (d->format & BAM_PLF_SIMPLE) {
- putchar('\t');
- for (i = 0; i < n; ++i) {
- int c = pu[i].b->core.qual + 33;
- if (c > 126) c = 126;
- putchar(c);
- }
- }
- // print read position
- if (d->format & BAM_PLF_READPOS) {
- putchar('\t');
- for (i = 0; i < n; ++i) {
- int x = pu[i].qpos;
- int l = pu[i].b->core.l_qseq;
- printf("%d,", x < l/2? x+1 : -((l-1)-x+1));
- }
- }
- putchar('\n');
- // print the indel line if r has been calculated. This only happens if:
- // a) -c or -i are flagged, AND b) the reference sequence is available
- if (r) {
- printf("%s\t%d\t*\t", d->h->target_name[tid], pos + 1);
- if (r->gt < 2) printf("%s/%s\t", r->s[r->gt], r->s[r->gt]);
- else printf("%s/%s\t", r->s[0], r->s[1]);
- printf("%d\t%d\t", r->q_cns, r->q_ref);
- printf("%d\t%d\t", rms_mapq, n);
- printf("%s\t%s\t", r->s[0], r->s[1]);
- //printf("%d\t%d\t", r->gl[0], r->gl[1]);
- printf("%d\t%d\t%d\t", r->cnt1, r->cnt2, r->cnt_anti);
- printf("%d\t%d\n", r->cnt_ref, r->cnt_ambi);
- bam_maqindel_ret_destroy(r);
- }
- return 0;
-}
-
-int bam_pileup(int argc, char *argv[])
-{
- int c, is_SAM = 0;
- char *fn_list = 0, *fn_fa = 0, *fn_pos = 0;
- pu_data_t *d = (pu_data_t*)calloc(1, sizeof(pu_data_t));
- d->max_depth = 0;
- d->tid = -1; d->mask = BAM_DEF_MASK;
- d->c = bam_maqcns_init();
- d->c->is_soap = 1; // change the default model
- d->ido = bam_maqindel_opt_init();
- while ((c = getopt(argc, argv, "st:f:cT:N:r:l:d:im:gI:G:vM:S2aR:PA")) >= 0) {
- switch (c) {
- case 'a': d->c->is_soap = 1; break;
- case 'A': d->c->is_soap = 0; break;
- case 's': d->format |= BAM_PLF_SIMPLE; break;
- case 't': fn_list = strdup(optarg); break;
- case 'l': fn_pos = strdup(optarg); break;
- case 'f': fn_fa = strdup(optarg); break;
- case 'T': d->c->theta = atof(optarg); break;
- case 'N': d->c->n_hap = atoi(optarg); break;
- case 'r': d->c->het_rate = atof(optarg); d->ido->r_snp = d->c->het_rate; break;
- case 'M': d->c->cap_mapQ = atoi(optarg); break;
- case 'd': d->max_depth = atoi(optarg); break;
- case 'c': d->format |= BAM_PLF_CNS; break;
- case 'i': d->format |= BAM_PLF_INDEL_ONLY; break;
- case 'v': d->format |= BAM_PLF_VAR_ONLY; break;
- case 'm': d->mask = strtol(optarg, 0, 0); break;
- case 'g': d->format |= BAM_PLF_GLF; break;
- case '2': d->format |= BAM_PLF_2ND; break;
- case 'P': d->format |= BAM_PLF_READPOS; break;
- case 'I': d->ido->q_indel = atoi(optarg); break;
- case 'G': d->ido->r_indel = atof(optarg); break;
- case 'S': is_SAM = 1; break;
- case 'R':
- if (strcmp(optarg, "random") == 0) d->format |= BAM_PLF_RANBASE;
- else if (strcmp(optarg, "first") == 0) d->format |= BAM_PLF_1STBASE;
- else if (strcmp(optarg, "all") == 0) d->format |= BAM_PLF_ALLBASE;
- else fprintf(stderr, "[bam_pileup] unrecognized -R\n");
- break;
- default: fprintf(stderr, "Unrecognizd option '-%c'.\n", c); return 1;
- }
- }
- if (fn_list) is_SAM = 1;
- if (optind == argc) {
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: samtools pileup [options] <in.bam>|<in.sam>\n\n");
- fprintf(stderr, "Option: -s simple (yet incomplete) pileup format\n");
- fprintf(stderr, " -S the input is in SAM\n");
- fprintf(stderr, " -A use the MAQ model for SNP calling\n");
- fprintf(stderr, " -2 output the 2nd best call and quality\n");
- fprintf(stderr, " -i only show lines/consensus with indels\n");
- fprintf(stderr, " -m INT filtering reads with bits in INT [%d]\n", d->mask);
- fprintf(stderr, " -M INT cap mapping quality at INT [%d]\n", d->c->cap_mapQ);
- fprintf(stderr, " -d INT limit maximum depth for indels [unlimited]\n");
- fprintf(stderr, " -t FILE list of reference sequences (force -S)\n");
- fprintf(stderr, " -l FILE list of sites at which pileup is output\n");
- fprintf(stderr, " -f FILE reference sequence in the FASTA format\n\n");
- fprintf(stderr, " -c output the SOAPsnp consensus sequence\n");
- fprintf(stderr, " -v print variants only (for -c)\n");
- fprintf(stderr, " -g output in the GLFv3 format (suppressing -c/-i/-s)\n");
- fprintf(stderr, " -T FLOAT theta in maq consensus calling model (for -c/-g) [%f]\n", d->c->theta);
- fprintf(stderr, " -N INT number of haplotypes in the sample (for -c/-g) [%d]\n", d->c->n_hap);
- fprintf(stderr, " -r FLOAT prior of a difference between two haplotypes (for -c/-g) [%f]\n", d->c->het_rate);
- fprintf(stderr, " -G FLOAT prior of an indel between two haplotypes (for -c/-g) [%f]\n", d->ido->r_indel);
- fprintf(stderr, " -I INT phred prob. of an indel in sequencing/prep. (for -c/-g) [%d]\n", d->ido->q_indel);
- fprintf(stderr, "\n");
- free(fn_list); free(fn_fa); free(d);
- return 1;
- }
- if (d->format & (BAM_PLF_RANBASE|BAM_PLF_1STBASE|BAM_PLF_ALLBASE)) d->format |= BAM_PLF_CNS;
- if (fn_fa) d->fai = fai_load(fn_fa);
- if (d->format & (BAM_PLF_CNS|BAM_PLF_GLF)) bam_maqcns_prepare(d->c); // consensus calling
- if (d->format & BAM_PLF_GLF) { // for glf output
- glf3_header_t *h;
- h = glf3_header_init();
- d->fp_glf = bgzf_fdopen(fileno(stdout), "w");
- glf3_header_write(d->fp_glf, h);
- glf3_header_destroy(h);
- }
- if (d->fai == 0 && (d->format & (BAM_PLF_CNS|BAM_PLF_INDEL_ONLY)))
- fprintf(stderr, "[bam_pileup] indels will not be called when -f is absent.\n");
- if (fn_fa && is_SAM && fn_list == 0) fn_list = samfaipath(fn_fa);
-
- {
- samfile_t *fp;
- fp = is_SAM? samopen(argv[optind], "r", fn_list) : samopen(argv[optind], "rb", 0);
- if (fp == 0 || fp->header == 0) {
- fprintf(stderr, "[bam_pileup] fail to read the header: non-exisiting file or wrong format.\n");
- return 1;
- }
- d->h = fp->header;
- if (fn_pos) d->hash = load_pos(fn_pos, d->h);
- sampileup(fp, d->mask, pileup_func, d);
- samclose(fp); // d->h will be destroyed here
- }
-
- // free
- if (d->format & BAM_PLF_GLF) bgzf_close(d->fp_glf);
- if (fn_pos) { // free the hash table
- khint_t k;
- for (k = kh_begin(d->hash); k < kh_end(d->hash); ++k)
- if (kh_exist(d->hash, k)) free(kh_val(d->hash, k));
- kh_destroy(64, d->hash);
- }
- free(fn_pos); free(fn_list); free(fn_fa);
- if (d->fai) fai_destroy(d->fai);
- bam_maqcns_destroy(d->c);
- free(d->ido); free(d->ref); free(d);
- return 0;
-}
-
-/***********
- * mpileup *
- ***********/
-
-typedef struct {
- char *reg;
- faidx_t *fai;
-} mplp_conf_t;
-
-typedef struct {
- bamFile fp;
- bam_iter_t iter;
-} mplp_aux_t;
-
-static int mplp_func(void *data, bam1_t *b)
-{
- mplp_aux_t *ma = (mplp_aux_t*)data;
- if (ma->iter) return bam_iter_read(ma->fp, ma->iter, b);
- return bam_read1(ma->fp, b);
-}
-
-static int mpileup(mplp_conf_t *conf, int n, char **fn)
-{
- mplp_aux_t **data;
- int i, tid, pos, *n_plp, beg0 = 0, end0 = 1u<<29, ref_len, ref_tid;
- const bam_pileup1_t **plp;
- bam_mplp_t iter;
- bam_header_t *h = 0;
- char *ref;
- // allocate
- data = calloc(n, sizeof(void*));
- plp = calloc(n, sizeof(void*));
- n_plp = calloc(n, sizeof(int*));
- // read the header and initialize data
- for (i = 0; i < n; ++i) {
- bam_header_t *h_tmp;
- data[i] = calloc(1, sizeof(mplp_aux_t));
- data[i]->fp = bam_open(fn[i], "r");
- h_tmp = bam_header_read(data[i]->fp);
- if (conf->reg) {
- int beg, end;
- bam_index_t *idx;
- idx = bam_index_load(fn[i]);
- if (idx == 0) {
- fprintf(stderr, "[%s] fail to load index for %d-th input.\n", __func__, i+1);
- exit(1);
- }
- if (bam_parse_region(h_tmp, conf->reg, &tid, &beg, &end) < 0) {
- fprintf(stderr, "[%s] malformatted region or wrong seqname for %d-th input.\n", __func__, i+1);
- exit(1);
- }
- if (i == 0) beg0 = beg, end0 = end;
- data[i]->iter = bam_iter_query(idx, tid, beg, end);
- bam_index_destroy(idx);
- }
- if (i == 0) h = h_tmp;
- else {
- // FIXME: to check consistency
- bam_header_destroy(h_tmp);
- }
- }
- // mpileup
- ref_tid = -1; ref = 0;
- iter = bam_mplp_init(n, mplp_func, (void**)data);
- while (bam_mplp_auto(iter, &tid, &pos, n_plp, plp) > 0) {
- if (conf->reg && (pos < beg0 || pos >= end0)) continue; // out of the region requested
- if (tid != ref_tid) {
- free(ref);
- if (conf->fai) ref = fai_fetch(conf->fai, h->target_name[tid], &ref_len);
- ref_tid = tid;
- }
- printf("%s\t%d\t%c", h->target_name[tid], pos + 1, (ref && pos < ref_len)? ref[pos] : 'N');
- for (i = 0; i < n; ++i) {
- int j;
- printf("\t%d\t", n_plp[i]);
- if (n_plp[i] == 0) printf("*\t*");
- else {
- for (j = 0; j < n_plp[i]; ++j)
- pileup_seq(plp[i] + j, pos, ref_len, ref);
- putchar('\t');
- for (j = 0; j < n_plp[i]; ++j) {
- const bam_pileup1_t *p = plp[i] + j;
- int c = bam1_qual(p->b)[p->qpos] + 33;
- if (c > 126) c = 126;
- putchar(c);
- }
- }
- }
- putchar('\n');
- }
- bam_mplp_destroy(iter);
- bam_header_destroy(h);
- for (i = 0; i < n; ++i) {
- bam_close(data[i]->fp);
- if (data[i]->iter) bam_iter_destroy(data[i]->iter);
- free(data[i]);
- }
- free(data); free(plp); free(ref); free(n_plp);
- return 0;
-}
-
-int bam_mpileup(int argc, char *argv[])
-{
- int c;
- mplp_conf_t mplp;
- memset(&mplp, 0, sizeof(mplp_conf_t));
- while ((c = getopt(argc, argv, "f:r:")) >= 0) {
- switch (c) {
- case 'f':
- mplp.fai = fai_load(optarg);
- if (mplp.fai == 0) return 1;
- break;
- case 'r': mplp.reg = strdup(optarg);
- }
- }
- if (argc == 1) {
- fprintf(stderr, "Usage: samtools mpileup [-r reg] [-f in.fa] in1.bam [in2.bam [...]]\n");
- return 1;
- }
- mpileup(&mplp, argc - optind, argv + optind);
- free(mplp.reg);
- if (mplp.fai) fai_destroy(mplp.fai);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include <stdio.h>
+#include <unistd.h>
+#include <ctype.h>
+#include <string.h>
+#include <errno.h>
+#include "sam.h"
+#include "faidx.h"
+#include "bam_maqcns.h"
+#include "khash.h"
+#include "glf.h"
+#include "kstring.h"
+
+typedef int *indel_list_t;
+KHASH_MAP_INIT_INT64(64, indel_list_t)
+
+#define BAM_PLF_SIMPLE 0x01
+#define BAM_PLF_CNS 0x02
+#define BAM_PLF_INDEL_ONLY 0x04
+#define BAM_PLF_GLF 0x08
+#define BAM_PLF_VAR_ONLY 0x10
+#define BAM_PLF_2ND 0x20
+#define BAM_PLF_RANBASE 0x40
+#define BAM_PLF_1STBASE 0x80
+#define BAM_PLF_ALLBASE 0x100
+#define BAM_PLF_READPOS 0x200
+#define BAM_PLF_NOBAQ 0x400
+
+typedef struct {
+ bam_header_t *h;
+ bam_maqcns_t *c;
+ bam_maqindel_opt_t *ido;
+ faidx_t *fai;
+ khash_t(64) *hash;
+ uint32_t format;
+ int tid, len, last_pos;
+ int mask;
+ int capQ_thres, min_baseQ;
+ int max_depth; // for indel calling, ignore reads with the depth too high. 0 for unlimited
+ char *ref;
+ glfFile fp_glf; // for glf output only
+} pu_data_t;
+
+char **__bam_get_lines(const char *fn, int *_n);
+void bam_init_header_hash(bam_header_t *header);
+int32_t bam_get_tid(const bam_header_t *header, const char *seq_name);
+
+static khash_t(64) *load_pos(const char *fn, bam_header_t *h)
+{
+ char **list;
+ int i, j, n, *fields, max_fields;
+ khash_t(64) *hash;
+ bam_init_header_hash(h);
+ list = __bam_get_lines(fn, &n);
+ hash = kh_init(64);
+ max_fields = 0; fields = 0;
+ for (i = 0; i < n; ++i) {
+ char *str = list[i];
+ int chr, n_fields, ret;
+ khint_t k;
+ uint64_t x;
+ n_fields = ksplit_core(str, 0, &max_fields, &fields);
+ if (n_fields < 2) continue;
+ chr = bam_get_tid(h, str + fields[0]);
+ if (chr < 0) {
+ fprintf(pysamerr, "[load_pos] unknown reference sequence name: %s\n", str + fields[0]);
+ continue;
+ }
+ x = (uint64_t)chr << 32 | (atoi(str + fields[1]) - 1);
+ k = kh_put(64, hash, x, &ret);
+ if (ret == 0) {
+ fprintf(pysamerr, "[load_pos] position %s:%s has been loaded.\n", str+fields[0], str+fields[1]);
+ continue;
+ }
+ kh_val(hash, k) = 0;
+ if (n_fields > 2) {
+ // count
+ for (j = 2; j < n_fields; ++j) {
+ char *s = str + fields[j];
+ if ((*s != '+' && *s != '-') || !isdigit(s[1])) break;
+ }
+ if (j > 2) { // update kh_val()
+ int *q, y, z;
+ q = kh_val(hash, k) = (int*)calloc(j - 1, sizeof(int));
+ q[0] = j - 2; z = j; y = 1;
+ for (j = 2; j < z; ++j)
+ q[y++] = atoi(str + fields[j]);
+ }
+ }
+ free(str);
+ }
+ free(list); free(fields);
+ return hash;
+}
+
+static inline int printw(int c, FILE *fp)
+{
+ char buf[16];
+ int l, x;
+ if (c == 0) return fputc('0', fp);
+ for (l = 0, x = c < 0? -c : c; x > 0; x /= 10) buf[l++] = x%10 + '0';
+ if (c < 0) buf[l++] = '-';
+ buf[l] = 0;
+ for (x = 0; x < l/2; ++x) {
+ int y = buf[x]; buf[x] = buf[l-1-x]; buf[l-1-x] = y;
+ }
+ fputs(buf, fp);
+ return 0;
+}
+
+// an analogy to pileup_func() below
+static int glt3_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pu, void *data)
+{
+ pu_data_t *d = (pu_data_t*)data;
+ bam_maqindel_ret_t *r = 0;
+ int rb, *proposed_indels = 0;
+ glf1_t *g;
+ glf3_t *g3;
+
+ if (d->fai == 0) {
+ fprintf(pysamerr, "[glt3_func] reference sequence is required for generating GLT. Abort!\n");
+ exit(1);
+ }
+ if (d->hash) { // only output a list of sites
+ khint_t k = kh_get(64, d->hash, (uint64_t)tid<<32|pos);
+ if (k == kh_end(d->hash)) return 0;
+ proposed_indels = kh_val(d->hash, k);
+ }
+ g3 = glf3_init1();
+ if (d->fai && (int)tid != d->tid) {
+ if (d->ref) { // then write the end mark
+ g3->rtype = GLF3_RTYPE_END;
+ glf3_write1(d->fp_glf, g3);
+ }
+ glf3_ref_write(d->fp_glf, d->h->target_name[tid], d->h->target_len[tid]); // write reference
+ free(d->ref);
+ d->ref = fai_fetch(d->fai, d->h->target_name[tid], &d->len);
+ d->tid = tid;
+ d->last_pos = 0;
+ }
+ rb = (d->ref && (int)pos < d->len)? d->ref[pos] : 'N';
+ g = bam_maqcns_glfgen(n, pu, bam_nt16_table[rb], d->c);
+ memcpy(g3, g, sizeof(glf1_t));
+ g3->rtype = GLF3_RTYPE_SUB;
+ g3->offset = pos - d->last_pos;
+ d->last_pos = pos;
+ glf3_write1(d->fp_glf, g3);
+ if (pos < d->len) {
+ int m = (!d->max_depth || d->max_depth>n) ? n : d->max_depth;
+ if (proposed_indels)
+ r = bam_maqindel(m, pos, d->ido, pu, d->ref, proposed_indels[0], proposed_indels+1);
+ else r = bam_maqindel(m, pos, d->ido, pu, d->ref, 0, 0);
+ }
+ if (r) { // then write indel line
+ int het = 3 * n, min;
+ min = het;
+ if (min > r->gl[0]) min = r->gl[0];
+ if (min > r->gl[1]) min = r->gl[1];
+ g3->ref_base = 0;
+ g3->rtype = GLF3_RTYPE_INDEL;
+ memset(g3->lk, 0, 10);
+ g3->lk[0] = r->gl[0] - min < 255? r->gl[0] - min : 255;
+ g3->lk[1] = r->gl[1] - min < 255? r->gl[1] - min : 255;
+ g3->lk[2] = het - min < 255? het - min : 255;
+ g3->offset = 0;
+ g3->indel_len[0] = r->indel1;
+ g3->indel_len[1] = r->indel2;
+ g3->min_lk = min < 255? min : 255;
+ g3->max_len = (abs(r->indel1) > abs(r->indel2)? abs(r->indel1) : abs(r->indel2)) + 1;
+ g3->indel_seq[0] = strdup(r->s[0]+1);
+ g3->indel_seq[1] = strdup(r->s[1]+1);
+ glf3_write1(d->fp_glf, g3);
+ bam_maqindel_ret_destroy(r);
+ }
+ free(g);
+ glf3_destroy1(g3);
+ return 0;
+}
+
+static inline void pileup_seq(const bam_pileup1_t *p, int pos, int ref_len, const char *ref)
+{
+ int j;
+ if (p->is_head) {
+ putchar('^');
+ putchar(p->b->core.qual > 93? 126 : p->b->core.qual + 33);
+ }
+ if (!p->is_del) {
+ int c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos)];
+ if (ref) {
+ int rb = pos < ref_len? ref[pos] : 'N';
+ if (c == '=' || bam_nt16_table[c] == bam_nt16_table[rb]) c = bam1_strand(p->b)? ',' : '.';
+ else c = bam1_strand(p->b)? tolower(c) : toupper(c);
+ } else {
+ if (c == '=') c = bam1_strand(p->b)? ',' : '.';
+ else c = bam1_strand(p->b)? tolower(c) : toupper(c);
+ }
+ putchar(c);
+ } else putchar(p->is_refskip? (bam1_strand(p->b)? '<' : '>') : '*');
+ if (p->indel > 0) {
+ putchar('+'); printw(p->indel, stdout);
+ for (j = 1; j <= p->indel; ++j) {
+ int c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos + j)];
+ putchar(bam1_strand(p->b)? tolower(c) : toupper(c));
+ }
+ } else if (p->indel < 0) {
+ printw(p->indel, stdout);
+ for (j = 1; j <= -p->indel; ++j) {
+ int c = (ref && (int)pos+j < ref_len)? ref[pos+j] : 'N';
+ putchar(bam1_strand(p->b)? tolower(c) : toupper(c));
+ }
+ }
+ if (p->is_tail) putchar('$');
+}
+
+static int pileup_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pu, void *data)
+{
+ pu_data_t *d = (pu_data_t*)data;
+ bam_maqindel_ret_t *r = 0;
+ int i, rb, rms_mapq = -1, *proposed_indels = 0;
+ uint64_t rms_aux;
+ uint32_t cns = 0;
+
+ // if GLF is required, suppress -c completely
+ if (d->format & BAM_PLF_GLF) return glt3_func(tid, pos, n, pu, data);
+ // if d->hash is initialized, only output the sites in the hash table
+ if (d->hash) {
+ khint_t k = kh_get(64, d->hash, (uint64_t)tid<<32|pos);
+ if (k == kh_end(d->hash)) return 0;
+ proposed_indels = kh_val(d->hash, k);
+ }
+ // update d->ref if necessary
+ if (d->fai && (int)tid != d->tid) {
+ free(d->ref);
+ d->ref = faidx_fetch_seq(d->fai, d->h->target_name[tid], 0, 0x7fffffff, &d->len);
+ d->tid = tid;
+ }
+ rb = (d->ref && (int)pos < d->len)? d->ref[pos] : 'N';
+ // when the indel-only mode is asked for, return if no reads mapped with indels
+ if (d->format & BAM_PLF_INDEL_ONLY) {
+ for (i = 0; i < n; ++i)
+ if (pu[i].indel != 0) break;
+ if (i == n) return 0;
+ }
+ // call the consensus and indel
+ if (d->format & BAM_PLF_CNS) { // call consensus
+ if (d->format & (BAM_PLF_RANBASE|BAM_PLF_1STBASE)) { // use a random base or the 1st base as the consensus call
+ const bam_pileup1_t *p = (d->format & BAM_PLF_1STBASE)? pu : pu + (int)(drand48() * n);
+ int q = bam1_qual(p->b)[p->qpos];
+ int mapQ = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
+ uint32_t b = bam1_seqi(bam1_seq(p->b), p->qpos);
+ cns = b<<28 | 0xf<<24 | mapQ<<16 | q<<8;
+ } else if (d->format & BAM_PLF_ALLBASE) { // collapse all bases
+ uint64_t rmsQ = 0;
+ uint32_t b = 0;
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pu + i;
+ int q = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
+ b |= bam1_seqi(bam1_seq(p->b), p->qpos);
+ rmsQ += q * q;
+ }
+ rmsQ = (uint64_t)(sqrt((double)rmsQ / n) + .499);
+ cns = b<<28 | 0xf<<24 | rmsQ<<16 | 60<<8;
+ } else {
+ glf1_t *g = bam_maqcns_glfgen(n, pu, bam_nt16_table[rb], d->c);
+ cns = g->depth == 0? (0xfu<<28 | 0xf<<24) : glf2cns(g, (int)(d->c->q_r + .499));
+ free(g);
+ }
+ }
+ if ((d->format & (BAM_PLF_CNS|BAM_PLF_INDEL_ONLY)) && d->ref && pos < d->len) { // call indels
+ int m = (!d->max_depth || d->max_depth>n) ? n : d->max_depth;
+ if (proposed_indels) // the first element gives the size of the array
+ r = bam_maqindel(m, pos, d->ido, pu, d->ref, proposed_indels[0], proposed_indels+1);
+ else r = bam_maqindel(m, pos, d->ido, pu, d->ref, 0, 0);
+ }
+ // when only variant sites are asked for, test if the site is a variant
+ if ((d->format & BAM_PLF_CNS) && (d->format & BAM_PLF_VAR_ONLY)) {
+ if (!(bam_nt16_table[rb] != 15 && cns>>28 != 15 && cns>>28 != bam_nt16_table[rb])) { // not a SNP
+ if (!(r && (r->gt == 2 || strcmp(r->s[r->gt], "*")))) { // not an indel
+ if (r) bam_maqindel_ret_destroy(r);
+ return 0;
+ }
+ }
+ }
+ // print the first 3 columns
+ fputs(d->h->target_name[tid], stdout); putchar('\t');
+ printw(pos+1, stdout); putchar('\t'); putchar(rb); putchar('\t');
+ // print consensus information if required
+ if (d->format & BAM_PLF_CNS) {
+ putchar(bam_nt16_rev_table[cns>>28]); putchar('\t');
+ printw(cns>>8&0xff, stdout); putchar('\t');
+ printw(cns&0xff, stdout); putchar('\t');
+ printw(cns>>16&0xff, stdout); putchar('\t');
+ }
+ // print pileup sequences
+ printw(n, stdout); putchar('\t');
+ for (i = 0; i < n; ++i)
+ pileup_seq(pu + i, pos, d->len, d->ref);
+ // finalize rms_mapq
+ if (d->format & BAM_PLF_CNS) {
+ for (i = rms_aux = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pu + i;
+ int tmp = p->b->core.qual < d->c->cap_mapQ? p->b->core.qual : d->c->cap_mapQ;
+ rms_aux += tmp * tmp;
+ }
+ rms_aux = (uint64_t)(sqrt((double)rms_aux / n) + .499);
+ if (rms_mapq < 0) rms_mapq = rms_aux;
+ }
+ putchar('\t');
+ // print quality
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pu + i;
+ int c = bam1_qual(p->b)[p->qpos] + 33;
+ if (c > 126) c = 126;
+ putchar(c);
+ }
+ if (d->format & BAM_PLF_2ND) { // print 2nd calls and qualities
+ const unsigned char *q;
+ putchar('\t');
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pu + i;
+ q = bam_aux_get(p->b, "E2");
+ putchar(q? q[p->qpos + 1] : 'N');
+ }
+ putchar('\t');
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pu + i;
+ q = bam_aux_get(p->b, "U2");
+ putchar(q? q[p->qpos + 1] : '!');
+ }
+ }
+ // print mapping quality if -s is flagged on the command line
+ if (d->format & BAM_PLF_SIMPLE) {
+ putchar('\t');
+ for (i = 0; i < n; ++i) {
+ int c = pu[i].b->core.qual + 33;
+ if (c > 126) c = 126;
+ putchar(c);
+ }
+ }
+ // print read position
+ if (d->format & BAM_PLF_READPOS) {
+ putchar('\t');
+ for (i = 0; i < n; ++i) {
+ int x = pu[i].qpos;
+ int l = pu[i].b->core.l_qseq;
+ printw(x < l/2? x+1 : -((l-1)-x+1), stdout); putchar(',');
+ }
+ }
+ putchar('\n');
+ // print the indel line if r has been calculated. This only happens if:
+ // a) -c or -i are flagged, AND b) the reference sequence is available
+ if (r) {
+ printf("%s\t%d\t*\t", d->h->target_name[tid], pos + 1);
+ if (r->gt < 2) printf("%s/%s\t", r->s[r->gt], r->s[r->gt]);
+ else printf("%s/%s\t", r->s[0], r->s[1]);
+ printf("%d\t%d\t", r->q_cns, r->q_ref);
+ printf("%d\t%d\t", rms_mapq, n);
+ printf("%s\t%s\t", r->s[0], r->s[1]);
+ //printf("%d\t%d\t", r->gl[0], r->gl[1]);
+ printf("%d\t%d\t%d\t", r->cnt1, r->cnt2, r->cnt_anti);
+ printf("%d\t%d\n", r->cnt_ref, r->cnt_ambi);
+ bam_maqindel_ret_destroy(r);
+ }
+ return 0;
+}
+
+int bam_pileup(int argc, char *argv[])
+{
+ int c, is_SAM = 0;
+ char *fn_list = 0, *fn_fa = 0, *fn_pos = 0;
+ pu_data_t *d = (pu_data_t*)calloc(1, sizeof(pu_data_t));
+ d->max_depth = 1024; d->tid = -1; d->mask = BAM_DEF_MASK; d->min_baseQ = 13;
+ d->c = bam_maqcns_init();
+ d->c->errmod = BAM_ERRMOD_MAQ2; // change the default model
+ d->ido = bam_maqindel_opt_init();
+ while ((c = getopt(argc, argv, "st:f:cT:N:r:l:d:im:gI:G:vM:S2aR:PAQ:C:B")) >= 0) {
+ switch (c) {
+ case 'Q': d->c->min_baseQ = atoi(optarg); break;
+ case 'C': d->capQ_thres = atoi(optarg); break;
+ case 'B': d->format |= BAM_PLF_NOBAQ; break;
+ case 'a': d->c->errmod = BAM_ERRMOD_SOAP; break;
+ case 'A': d->c->errmod = BAM_ERRMOD_MAQ; break;
+ case 's': d->format |= BAM_PLF_SIMPLE; break;
+ case 't': fn_list = strdup(optarg); break;
+ case 'l': fn_pos = strdup(optarg); break;
+ case 'f': fn_fa = strdup(optarg); break;
+ case 'T': d->c->theta = atof(optarg); break;
+ case 'N': d->c->n_hap = atoi(optarg); break;
+ case 'r': d->c->het_rate = atof(optarg); d->ido->r_snp = d->c->het_rate; break;
+ case 'M': d->c->cap_mapQ = atoi(optarg); break;
+ case 'd': d->max_depth = atoi(optarg); break;
+ case 'c': d->format |= BAM_PLF_CNS; break;
+ case 'i': d->format |= BAM_PLF_INDEL_ONLY; break;
+ case 'v': d->format |= BAM_PLF_VAR_ONLY; break;
+ case 'm': d->mask = strtol(optarg, 0, 0); break;
+ case 'g': d->format |= BAM_PLF_GLF; break;
+ case '2': d->format |= BAM_PLF_2ND; break;
+ case 'P': d->format |= BAM_PLF_READPOS; break;
+ case 'I': d->ido->q_indel = atoi(optarg); break;
+ case 'G': d->ido->r_indel = atof(optarg); break;
+ case 'S': is_SAM = 1; break;
+ case 'R':
+ if (strcmp(optarg, "random") == 0) d->format |= BAM_PLF_RANBASE;
+ else if (strcmp(optarg, "first") == 0) d->format |= BAM_PLF_1STBASE;
+ else if (strcmp(optarg, "all") == 0) d->format |= BAM_PLF_ALLBASE;
+ else fprintf(pysamerr, "[bam_pileup] unrecognized -R\n");
+ break;
+ default: fprintf(pysamerr, "Unrecognizd option '-%c'.\n", c); return 1;
+ }
+ }
+ if (d->c->errmod != BAM_ERRMOD_MAQ2) d->c->theta += 0.02;
+ if (d->c->theta > 1.0) d->c->theta = 1.0;
+ if (fn_list) is_SAM = 1;
+ if (optind == argc) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools pileup [options] <in.bam>|<in.sam>\n\n");
+ fprintf(pysamerr, "Option: -s simple (yet incomplete) pileup format\n");
+ fprintf(pysamerr, " -S the input is in SAM\n");
+ fprintf(pysamerr, " -B disable BAQ computation\n");
+ fprintf(pysamerr, " -A use the original MAQ model for SNP calling (DEPRECATED)\n");
+ fprintf(pysamerr, " -2 output the 2nd best call and quality\n");
+ fprintf(pysamerr, " -i only show lines/consensus with indels\n");
+ fprintf(pysamerr, " -Q INT min base quality (possibly capped by BAQ) [%d]\n", d->c->min_baseQ);
+ fprintf(pysamerr, " -C INT coefficient for adjusting mapQ of poor mappings [%d]\n", d->capQ_thres);
+ fprintf(pysamerr, " -m INT filtering reads with bits in INT [0x%x]\n", d->mask);
+ fprintf(pysamerr, " -M INT cap mapping quality at INT [%d]\n", d->c->cap_mapQ);
+ fprintf(pysamerr, " -d INT limit maximum depth for indels [%d]\n", d->max_depth);
+ fprintf(pysamerr, " -t FILE list of reference sequences (force -S)\n");
+ fprintf(pysamerr, " -l FILE list of sites at which pileup is output\n");
+ fprintf(pysamerr, " -f FILE reference sequence in the FASTA format\n\n");
+ fprintf(pysamerr, " -c compute the consensus sequence\n");
+ fprintf(pysamerr, " -v print variants only (for -c)\n");
+ fprintf(pysamerr, " -g output in the GLFv3 format (DEPRECATED)\n");
+ fprintf(pysamerr, " -T FLOAT theta in maq consensus calling model (for -c) [%.4g]\n", d->c->theta);
+ fprintf(pysamerr, " -N INT number of haplotypes in the sample (for -c) [%d]\n", d->c->n_hap);
+ fprintf(pysamerr, " -r FLOAT prior of a difference between two haplotypes (for -c) [%.4g]\n", d->c->het_rate);
+ fprintf(pysamerr, " -G FLOAT prior of an indel between two haplotypes (for -c) [%.4g]\n", d->ido->r_indel);
+ fprintf(pysamerr, " -I INT phred prob. of an indel in sequencing/prep. (for -c) [%d]\n", d->ido->q_indel);
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Warning: Please use the `mpileup' command instead `pileup'. `Pileup' is deprecated!\n\n");
+ free(fn_list); free(fn_fa); free(d);
+ return 1;
+ }
+ if (d->format & (BAM_PLF_RANBASE|BAM_PLF_1STBASE|BAM_PLF_ALLBASE)) d->format |= BAM_PLF_CNS;
+ if (fn_fa) d->fai = fai_load(fn_fa);
+ if (d->format & (BAM_PLF_CNS|BAM_PLF_GLF)) bam_maqcns_prepare(d->c); // consensus calling
+ if (d->format & BAM_PLF_GLF) { // for glf output
+ glf3_header_t *h;
+ h = glf3_header_init();
+ d->fp_glf = bgzf_fdopen(fileno(stdout), "w");
+ glf3_header_write(d->fp_glf, h);
+ glf3_header_destroy(h);
+ }
+ if (d->fai == 0 && (d->format & (BAM_PLF_CNS|BAM_PLF_INDEL_ONLY)))
+ fprintf(pysamerr, "[bam_pileup] indels will not be called when -f is absent.\n");
+ if (fn_fa && is_SAM && fn_list == 0) fn_list = samfaipath(fn_fa);
+
+ {
+ samfile_t *fp;
+ fp = is_SAM? samopen(argv[optind], "r", fn_list) : samopen(argv[optind], "rb", 0);
+ if (fp == 0 || fp->header == 0) {
+ fprintf(pysamerr, "[bam_pileup] fail to read the header: non-exisiting file or wrong format.\n");
+ return 1;
+ }
+ d->h = fp->header;
+ if (fn_pos) d->hash = load_pos(fn_pos, d->h);
+ { // run pileup
+ extern int bam_prob_realn(bam1_t *b, const char *ref);
+ extern int bam_cap_mapQ(bam1_t *b, char *ref, int thres);
+ bam1_t *b;
+ int ret, tid, pos, n_plp;
+ bam_plp_t iter;
+ const bam_pileup1_t *plp;
+ b = bam_init1();
+ iter = bam_plp_init(0, 0);
+ bam_plp_set_mask(iter, d->mask);
+ while ((ret = samread(fp, b)) >= 0) {
+ int skip = 0;
+ if ((int)b->core.tid < 0) break;
+ // update d->ref if necessary
+ if (d->fai && (int)b->core.tid != d->tid) {
+ free(d->ref);
+ d->ref = faidx_fetch_seq(d->fai, d->h->target_name[b->core.tid], 0, 0x7fffffff, &d->len);
+ d->tid = b->core.tid;
+ }
+ if (d->ref && (d->format&BAM_PLF_CNS) && !(d->format&BAM_PLF_NOBAQ)) bam_prob_realn(b, d->ref);
+ if (d->ref && (d->format&BAM_PLF_CNS) && d->capQ_thres > 10) {
+ int q = bam_cap_mapQ(b, d->ref, d->capQ_thres);
+ if (q < 0) skip = 1;
+ else if (b->core.qual > q) b->core.qual = q;
+ } else if (b->core.flag&BAM_FUNMAP) skip = 1;
+ else if ((d->format&BAM_PLF_CNS) && (b->core.flag&1) && !(b->core.flag&2)) skip = 1;
+ if (skip) continue;
+ bam_plp_push(iter, b);
+ while ((plp = bam_plp_next(iter, &tid, &pos, &n_plp)) != 0)
+ pileup_func(tid, pos, n_plp, plp, d);
+ }
+ bam_plp_push(iter, 0);
+ while ((plp = bam_plp_next(iter, &tid, &pos, &n_plp)) != 0)
+ pileup_func(tid, pos, n_plp, plp, d);
+ bam_plp_destroy(iter);
+ bam_destroy1(b);
+ }
+ samclose(fp); // d->h will be destroyed here
+ }
+
+ // free
+ if (d->format & BAM_PLF_GLF) bgzf_close(d->fp_glf);
+ if (fn_pos) { // free the hash table
+ khint_t k;
+ for (k = kh_begin(d->hash); k < kh_end(d->hash); ++k)
+ if (kh_exist(d->hash, k)) free(kh_val(d->hash, k));
+ kh_destroy(64, d->hash);
+ }
+ free(fn_pos); free(fn_list); free(fn_fa);
+ if (d->fai) fai_destroy(d->fai);
+ bam_maqcns_destroy(d->c);
+ free(d->ido); free(d->ref); free(d);
+ return 0;
+}
+
+/***********
+ * mpileup *
+ ***********/
+
+#include <assert.h>
+#include "bam2bcf.h"
+#include "sample.h"
+
+#define MPLP_GLF 0x10
+#define MPLP_NO_COMP 0x20
+#define MPLP_NO_ORPHAN 0x40
+#define MPLP_REALN 0x80
+#define MPLP_FMT_DP 0x100
+#define MPLP_FMT_SP 0x200
+#define MPLP_NO_INDEL 0x400
+#define MPLP_EXT_BAQ 0x800
+#define MPLP_ILLUMINA13 0x1000
+
+void *bed_read(const char *fn);
+void bed_destroy(void *_h);
+int bed_overlap(const void *_h, const char *chr, int beg, int end);
+
+typedef struct {
+ int max_mq, min_mq, flag, min_baseQ, capQ_thres, max_depth, max_indel_depth;
+ int openQ, extQ, tandemQ, min_support; // for indels
+ double min_frac; // for indels
+ char *reg, *pl_list;
+ faidx_t *fai;
+ void *bed, *rghash;
+} mplp_conf_t;
+
+typedef struct {
+ bamFile fp;
+ bam_iter_t iter;
+ bam_header_t *h;
+ int ref_id;
+ char *ref;
+ const mplp_conf_t *conf;
+} mplp_aux_t;
+
+typedef struct {
+ int n;
+ int *n_plp, *m_plp;
+ bam_pileup1_t **plp;
+} mplp_pileup_t;
+
+static int mplp_func(void *data, bam1_t *b)
+{
+ extern int bam_realn(bam1_t *b, const char *ref);
+ extern int bam_prob_realn_core(bam1_t *b, const char *ref, int);
+ extern int bam_cap_mapQ(bam1_t *b, char *ref, int thres);
+ mplp_aux_t *ma = (mplp_aux_t*)data;
+ int ret, skip = 0;
+ do {
+ int has_ref;
+ ret = ma->iter? bam_iter_read(ma->fp, ma->iter, b) : bam_read1(ma->fp, b);
+ if (ret < 0) break;
+ if (b->core.tid < 0 || (b->core.flag&BAM_FUNMAP)) { // exclude unmapped reads
+ skip = 1;
+ continue;
+ }
+ if (ma->conf->bed) { // test overlap
+ skip = !bed_overlap(ma->conf->bed, ma->h->target_name[b->core.tid], b->core.pos, bam_calend(&b->core, bam1_cigar(b)));
+ if (skip) continue;
+ }
+ if (ma->conf->rghash) { // exclude read groups
+ uint8_t *rg = bam_aux_get(b, "RG");
+ skip = (rg && bcf_str2id(ma->conf->rghash, (const char*)(rg+1)) >= 0);
+ if (skip) continue;
+ }
+ if (ma->conf->flag & MPLP_ILLUMINA13) {
+ int i;
+ uint8_t *qual = bam1_qual(b);
+ for (i = 0; i < b->core.l_qseq; ++i)
+ qual[i] = qual[i] > 31? qual[i] - 31 : 0;
+ }
+ has_ref = (ma->ref && ma->ref_id == b->core.tid)? 1 : 0;
+ skip = 0;
+ if (has_ref && (ma->conf->flag&MPLP_REALN)) bam_prob_realn_core(b, ma->ref, (ma->conf->flag & MPLP_EXT_BAQ)? 3 : 1);
+ if (has_ref && ma->conf->capQ_thres > 10) {
+ int q = bam_cap_mapQ(b, ma->ref, ma->conf->capQ_thres);
+ if (q < 0) skip = 1;
+ else if (b->core.qual > q) b->core.qual = q;
+ }
+ else if (b->core.qual < ma->conf->min_mq) skip = 1;
+ else if ((ma->conf->flag&MPLP_NO_ORPHAN) && (b->core.flag&1) && !(b->core.flag&2)) skip = 1;
+ } while (skip);
+ return ret;
+}
+
+static void group_smpl(mplp_pileup_t *m, bam_sample_t *sm, kstring_t *buf,
+ int n, char *const*fn, int *n_plp, const bam_pileup1_t **plp)
+{
+ int i, j;
+ memset(m->n_plp, 0, m->n * sizeof(int));
+ for (i = 0; i < n; ++i) {
+ for (j = 0; j < n_plp[i]; ++j) {
+ const bam_pileup1_t *p = plp[i] + j;
+ uint8_t *q;
+ int id = -1;
+ q = bam_aux_get(p->b, "RG");
+ if (q) id = bam_smpl_rg2smid(sm, fn[i], (char*)q+1, buf);
+ if (id < 0) id = bam_smpl_rg2smid(sm, fn[i], 0, buf);
+ if (id < 0 || id >= m->n) {
+ assert(q); // otherwise a bug
+ fprintf(pysamerr, "[%s] Read group %s used in file %s but absent from the header or an alignment missing read group.\n", __func__, (char*)q+1, fn[i]);
+ exit(1);
+ }
+ if (m->n_plp[id] == m->m_plp[id]) {
+ m->m_plp[id] = m->m_plp[id]? m->m_plp[id]<<1 : 8;
+ m->plp[id] = realloc(m->plp[id], sizeof(bam_pileup1_t) * m->m_plp[id]);
+ }
+ m->plp[id][m->n_plp[id]++] = *p;
+ }
+ }
+}
+
+static int mpileup(mplp_conf_t *conf, int n, char **fn)
+{
+ extern void *bcf_call_add_rg(void *rghash, const char *hdtext, const char *list);
+ extern void bcf_call_del_rghash(void *rghash);
+ mplp_aux_t **data;
+ int i, tid, pos, *n_plp, beg0 = 0, end0 = 1u<<29, ref_len, ref_tid, max_depth, max_indel_depth;
+ const bam_pileup1_t **plp;
+ bam_mplp_t iter;
+ bam_header_t *h = 0;
+ char *ref;
+ void *rghash = 0;
+
+ bcf_callaux_t *bca = 0;
+ bcf_callret1_t *bcr = 0;
+ bcf_call_t bc;
+ bcf_t *bp = 0;
+ bcf_hdr_t *bh = 0;
+
+ bam_sample_t *sm = 0;
+ kstring_t buf;
+ mplp_pileup_t gplp;
+
+ memset(&gplp, 0, sizeof(mplp_pileup_t));
+ memset(&buf, 0, sizeof(kstring_t));
+ memset(&bc, 0, sizeof(bcf_call_t));
+ data = calloc(n, sizeof(void*));
+ plp = calloc(n, sizeof(void*));
+ n_plp = calloc(n, sizeof(int*));
+ sm = bam_smpl_init();
+
+ // read the header and initialize data
+ for (i = 0; i < n; ++i) {
+ bam_header_t *h_tmp;
+ data[i] = calloc(1, sizeof(mplp_aux_t));
+ data[i]->fp = strcmp(fn[i], "-") == 0? bam_dopen(fileno(stdin), "r") : bam_open(fn[i], "r");
+ data[i]->conf = conf;
+ h_tmp = bam_header_read(data[i]->fp);
+ data[i]->h = i? h : h_tmp; // for i==0, "h" has not been set yet
+ bam_smpl_add(sm, fn[i], h_tmp->text);
+ rghash = bcf_call_add_rg(rghash, h_tmp->text, conf->pl_list);
+ if (conf->reg) {
+ int beg, end;
+ bam_index_t *idx;
+ idx = bam_index_load(fn[i]);
+ if (idx == 0) {
+ fprintf(pysamerr, "[%s] fail to load index for %d-th input.\n", __func__, i+1);
+ exit(1);
+ }
+ if (bam_parse_region(h_tmp, conf->reg, &tid, &beg, &end) < 0) {
+ fprintf(pysamerr, "[%s] malformatted region or wrong seqname for %d-th input.\n", __func__, i+1);
+ exit(1);
+ }
+ if (i == 0) beg0 = beg, end0 = end;
+ data[i]->iter = bam_iter_query(idx, tid, beg, end);
+ bam_index_destroy(idx);
+ }
+ if (i == 0) h = h_tmp;
+ else {
+ // FIXME: to check consistency
+ bam_header_destroy(h_tmp);
+ }
+ }
+ gplp.n = sm->n;
+ gplp.n_plp = calloc(sm->n, sizeof(int));
+ gplp.m_plp = calloc(sm->n, sizeof(int));
+ gplp.plp = calloc(sm->n, sizeof(void*));
+
+ fprintf(pysamerr, "[%s] %d samples in %d input files\n", __func__, sm->n, n);
+ // write the VCF header
+ if (conf->flag & MPLP_GLF) {
+ kstring_t s;
+ bh = calloc(1, sizeof(bcf_hdr_t));
+ s.l = s.m = 0; s.s = 0;
+ bp = bcf_open("-", (conf->flag&MPLP_NO_COMP)? "wu" : "w");
+ for (i = 0; i < h->n_targets; ++i) {
+ kputs(h->target_name[i], &s);
+ kputc('\0', &s);
+ }
+ bh->l_nm = s.l;
+ bh->name = malloc(s.l);
+ memcpy(bh->name, s.s, s.l);
+ s.l = 0;
+ for (i = 0; i < sm->n; ++i) {
+ kputs(sm->smpl[i], &s); kputc('\0', &s);
+ }
+ bh->l_smpl = s.l;
+ bh->sname = malloc(s.l);
+ memcpy(bh->sname, s.s, s.l);
+ bh->txt = malloc(strlen(BAM_VERSION) + 64);
+ bh->l_txt = 1 + sprintf(bh->txt, "##samtoolsVersion=%s\n", BAM_VERSION);
+ free(s.s);
+ bcf_hdr_sync(bh);
+ bcf_hdr_write(bp, bh);
+ bca = bcf_call_init(-1., conf->min_baseQ);
+ bcr = calloc(sm->n, sizeof(bcf_callret1_t));
+ bca->rghash = rghash;
+ bca->openQ = conf->openQ, bca->extQ = conf->extQ, bca->tandemQ = conf->tandemQ;
+ bca->min_frac = conf->min_frac;
+ bca->min_support = conf->min_support;
+ }
+ ref_tid = -1; ref = 0;
+ iter = bam_mplp_init(n, mplp_func, (void**)data);
+ max_depth = conf->max_depth;
+ if (max_depth * sm->n > 1<<20)
+ fprintf(pysamerr, "(%s) Max depth is above 1M. Potential memory hog!\n", __func__);
+ if (max_depth * sm->n < 8000) {
+ max_depth = 8000 / sm->n;
+ fprintf(pysamerr, "<%s> Set max per-file depth to %d\n", __func__, max_depth);
+ }
+ max_indel_depth = conf->max_indel_depth * sm->n;
+ bam_mplp_set_maxcnt(iter, max_depth);
+ while (bam_mplp_auto(iter, &tid, &pos, n_plp, plp) > 0) {
+ if (conf->reg && (pos < beg0 || pos >= end0)) continue; // out of the region requested
+ if (conf->bed && tid >= 0 && !bed_overlap(conf->bed, h->target_name[tid], pos, pos+1)) continue;
+ if (tid != ref_tid) {
+ free(ref); ref = 0;
+ if (conf->fai) ref = fai_fetch(conf->fai, h->target_name[tid], &ref_len);
+ for (i = 0; i < n; ++i) data[i]->ref = ref, data[i]->ref_id = tid;
+ ref_tid = tid;
+ }
+ if (conf->flag & MPLP_GLF) {
+ int total_depth, _ref0, ref16;
+ bcf1_t *b = calloc(1, sizeof(bcf1_t));
+ for (i = total_depth = 0; i < n; ++i) total_depth += n_plp[i];
+ group_smpl(&gplp, sm, &buf, n, fn, n_plp, plp);
+ _ref0 = (ref && pos < ref_len)? ref[pos] : 'N';
+ ref16 = bam_nt16_table[_ref0];
+ for (i = 0; i < gplp.n; ++i)
+ bcf_call_glfgen(gplp.n_plp[i], gplp.plp[i], ref16, bca, bcr + i);
+ bcf_call_combine(gplp.n, bcr, ref16, &bc);
+ bcf_call2bcf(tid, pos, &bc, b, (conf->flag&(MPLP_FMT_DP|MPLP_FMT_SP))? bcr : 0,
+ (conf->flag&MPLP_FMT_SP), 0, 0);
+ bcf_write(bp, bh, b);
+ bcf_destroy(b);
+ // call indels
+ if (!(conf->flag&MPLP_NO_INDEL) && total_depth < max_indel_depth && bcf_call_gap_prep(gplp.n, gplp.n_plp, gplp.plp, pos, bca, ref, rghash) >= 0) {
+ for (i = 0; i < gplp.n; ++i)
+ bcf_call_glfgen(gplp.n_plp[i], gplp.plp[i], -1, bca, bcr + i);
+ if (bcf_call_combine(gplp.n, bcr, -1, &bc) >= 0) {
+ b = calloc(1, sizeof(bcf1_t));
+ bcf_call2bcf(tid, pos, &bc, b, (conf->flag&(MPLP_FMT_DP|MPLP_FMT_SP))? bcr : 0,
+ (conf->flag&MPLP_FMT_SP), bca, ref);
+ bcf_write(bp, bh, b);
+ bcf_destroy(b);
+ }
+ }
+ } else {
+ printf("%s\t%d\t%c", h->target_name[tid], pos + 1, (ref && pos < ref_len)? ref[pos] : 'N');
+ for (i = 0; i < n; ++i) {
+ int j;
+ printf("\t%d\t", n_plp[i]);
+ if (n_plp[i] == 0) printf("*\t*");
+ else {
+ for (j = 0; j < n_plp[i]; ++j)
+ pileup_seq(plp[i] + j, pos, ref_len, ref);
+ putchar('\t');
+ for (j = 0; j < n_plp[i]; ++j) {
+ const bam_pileup1_t *p = plp[i] + j;
+ int c = bam1_qual(p->b)[p->qpos] + 33;
+ if (c > 126) c = 126;
+ putchar(c);
+ }
+ }
+ }
+ putchar('\n');
+ }
+ }
+
+ bcf_close(bp);
+ bam_smpl_destroy(sm); free(buf.s);
+ for (i = 0; i < gplp.n; ++i) free(gplp.plp[i]);
+ free(gplp.plp); free(gplp.n_plp); free(gplp.m_plp);
+ bcf_call_del_rghash(rghash);
+ bcf_hdr_destroy(bh); bcf_call_destroy(bca); free(bc.PL); free(bcr);
+ bam_mplp_destroy(iter);
+ bam_header_destroy(h);
+ for (i = 0; i < n; ++i) {
+ bam_close(data[i]->fp);
+ if (data[i]->iter) bam_iter_destroy(data[i]->iter);
+ free(data[i]);
+ }
+ free(data); free(plp); free(ref); free(n_plp);
+ return 0;
+}
+
+#define MAX_PATH_LEN 1024
+static int read_file_list(const char *file_list,int *n,char **argv[])
+{
+ char buf[MAX_PATH_LEN];
+ int len, nfiles;
+ char **files;
+
+ FILE *fh = fopen(file_list,"r");
+ if ( !fh )
+ {
+ fprintf(pysamerr,"%s: %s\n", file_list,strerror(errno));
+ return 1;
+ }
+
+ // Speed is not an issue here, determine the number of files by reading the file twice
+ nfiles = 0;
+ while ( fgets(buf,MAX_PATH_LEN,fh) ) nfiles++;
+
+ if ( fseek(fh, 0L, SEEK_SET) )
+ {
+ fprintf(pysamerr,"%s: %s\n", file_list,strerror(errno));
+ return 1;
+ }
+
+ files = calloc(nfiles,sizeof(char*));
+ nfiles = 0;
+ while ( fgets(buf,MAX_PATH_LEN,fh) )
+ {
+ len = strlen(buf);
+ while ( len>0 && isspace(buf[len-1]) ) len--;
+ if ( !len ) continue;
+
+ files[nfiles] = malloc(sizeof(char)*(len+1));
+ strncpy(files[nfiles],buf,len);
+ files[nfiles][len] = 0;
+ nfiles++;
+ }
+ fclose(fh);
+ if ( !nfiles )
+ {
+ fprintf(pysamerr,"No files read from %s\n", file_list);
+ return 1;
+ }
+ *argv = files;
+ *n = nfiles;
+ return 0;
+}
+#undef MAX_PATH_LEN
+
+int bam_mpileup(int argc, char *argv[])
+{
+ int c;
+ const char *file_list = NULL;
+ char **fn = NULL;
+ int nfiles = 0, use_orphan = 0;
+ mplp_conf_t mplp;
+ memset(&mplp, 0, sizeof(mplp_conf_t));
+ mplp.max_mq = 60;
+ mplp.min_baseQ = 13;
+ mplp.capQ_thres = 0;
+ mplp.max_depth = 250; mplp.max_indel_depth = 250;
+ mplp.openQ = 40; mplp.extQ = 20; mplp.tandemQ = 100;
+ mplp.min_frac = 0.002; mplp.min_support = 1;
+ mplp.flag = MPLP_NO_ORPHAN | MPLP_REALN;
+ while ((c = getopt(argc, argv, "Agf:r:l:M:q:Q:uaRC:BDSd:L:b:P:o:e:h:Im:F:EG:6")) >= 0) {
+ switch (c) {
+ case 'f':
+ mplp.fai = fai_load(optarg);
+ if (mplp.fai == 0) return 1;
+ break;
+ case 'd': mplp.max_depth = atoi(optarg); break;
+ case 'r': mplp.reg = strdup(optarg); break;
+ case 'l': mplp.bed = bed_read(optarg); break;
+ case 'P': mplp.pl_list = strdup(optarg); break;
+ case 'g': mplp.flag |= MPLP_GLF; break;
+ case 'u': mplp.flag |= MPLP_NO_COMP | MPLP_GLF; break;
+ case 'a': mplp.flag |= MPLP_NO_ORPHAN | MPLP_REALN; break;
+ case 'B': mplp.flag &= ~MPLP_REALN; break;
+ case 'R': mplp.flag |= MPLP_REALN; break;
+ case 'D': mplp.flag |= MPLP_FMT_DP; break;
+ case 'S': mplp.flag |= MPLP_FMT_SP; break;
+ case 'I': mplp.flag |= MPLP_NO_INDEL; break;
+ case 'E': mplp.flag |= MPLP_EXT_BAQ; break;
+ case '6': mplp.flag |= MPLP_ILLUMINA13; break;
+ case 'C': mplp.capQ_thres = atoi(optarg); break;
+ case 'M': mplp.max_mq = atoi(optarg); break;
+ case 'q': mplp.min_mq = atoi(optarg); break;
+ case 'Q': mplp.min_baseQ = atoi(optarg); break;
+ case 'b': file_list = optarg; break;
+ case 'o': mplp.openQ = atoi(optarg); break;
+ case 'e': mplp.extQ = atoi(optarg); break;
+ case 'h': mplp.tandemQ = atoi(optarg); break;
+ case 'A': use_orphan = 1; break;
+ case 'F': mplp.min_frac = atof(optarg); break;
+ case 'm': mplp.min_support = atoi(optarg); break;
+ case 'L': mplp.max_indel_depth = atoi(optarg); break;
+ case 'G': {
+ FILE *fp_rg;
+ char buf[1024];
+ mplp.rghash = bcf_str2id_init();
+ if ((fp_rg = fopen(optarg, "r")) == 0)
+ fprintf(pysamerr, "(%s) Fail to open file %s. Continue anyway.\n", __func__, optarg);
+ while (!feof(fp_rg) && fscanf(fp_rg, "%s", buf) > 0) // this is not a good style, but forgive me...
+ bcf_str2id_add(mplp.rghash, strdup(buf));
+ fclose(fp_rg);
+ }
+ break;
+ }
+ }
+ if (use_orphan) mplp.flag &= ~MPLP_NO_ORPHAN;
+ if (argc == 1) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools mpileup [options] in1.bam [in2.bam [...]]\n\n");
+ fprintf(pysamerr, "Input options:\n\n");
+ fprintf(pysamerr, " -6 assume the quality is in the Illumina-1.3+ encoding\n");
+ fprintf(pysamerr, " -A count anomalous read pairs\n");
+ fprintf(pysamerr, " -B disable BAQ computation\n");
+ fprintf(pysamerr, " -b FILE list of input BAM files [null]\n");
+ fprintf(pysamerr, " -d INT max per-BAM depth to avoid excessive memory usage [%d]\n", mplp.max_depth);
+ fprintf(pysamerr, " -E extended BAQ for higher sensitivity but lower specificity\n");
+ fprintf(pysamerr, " -f FILE faidx indexed reference sequence file [null]\n");
+ fprintf(pysamerr, " -G FILE exclude read groups listed in FILE [null]\n");
+ fprintf(pysamerr, " -l FILE list of positions (chr pos) or regions (BED) [null]\n");
+ fprintf(pysamerr, " -M INT cap mapping quality at INT [%d]\n", mplp.max_mq);
+ fprintf(pysamerr, " -r STR region in which pileup is generated [null]\n");
+ fprintf(pysamerr, " -q INT skip alignments with mapQ smaller than INT [%d]\n", mplp.min_mq);
+ fprintf(pysamerr, " -Q INT skip bases with baseQ/BAQ smaller than INT [%d]\n", mplp.min_baseQ);
+ fprintf(pysamerr, "\nOutput options:\n\n");
+ fprintf(pysamerr, " -D output per-sample DP in BCF (require -g/-u)\n");
+ fprintf(pysamerr, " -g generate BCF output (genotype likelihoods)\n");
+ fprintf(pysamerr, " -S output per-sample strand bias P-value in BCF (require -g/-u)\n");
+ fprintf(pysamerr, " -u generate uncompress BCF output\n");
+ fprintf(pysamerr, "\nSNP/INDEL genotype likelihoods options (effective with `-g' or `-u'):\n\n");
+ fprintf(pysamerr, " -e INT Phred-scaled gap extension seq error probability [%d]\n", mplp.extQ);
+ fprintf(pysamerr, " -F FLOAT minimum fraction of gapped reads for candidates [%g]\n", mplp.min_frac);
+ fprintf(pysamerr, " -h INT coefficient for homopolymer errors [%d]\n", mplp.tandemQ);
+ fprintf(pysamerr, " -I do not perform indel calling\n");
+ fprintf(pysamerr, " -L INT max per-sample depth for INDEL calling [%d]\n", mplp.max_indel_depth);
+ fprintf(pysamerr, " -m INT minimum gapped reads for indel candidates [%d]\n", mplp.min_support);
+ fprintf(pysamerr, " -o INT Phred-scaled gap open sequencing error probability [%d]\n", mplp.openQ);
+ fprintf(pysamerr, " -P STR comma separated list of platforms for indels [all]\n");
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Notes: Assuming diploid individuals.\n\n");
+ return 1;
+ }
+ if (file_list) {
+ if ( read_file_list(file_list,&nfiles,&fn) ) return 1;
+ mpileup(&mplp,nfiles,fn);
+ for (c=0; c<nfiles; c++) free(fn[c]);
+ free(fn);
+ } else mpileup(&mplp, argc - optind, argv + optind);
+ if (mplp.rghash) bcf_str2id_thorough_destroy(mplp.rghash);
+ free(mplp.reg); free(mplp.pl_list);
+ if (mplp.fai) fai_destroy(mplp.fai);
+ if (mplp.bed) bed_destroy(mplp.bed);
+ return 0;
+}
+++ /dev/null
-#include <stdio.h>
-#include <stdlib.h>
-#include "bgzf.h"
-#include "bam.h"
-
-#define BUF_SIZE 0x10000
-
-int bam_reheader(BGZF *in, const bam_header_t *h, int fd)
-{
- BGZF *fp;
- bam_header_t *old;
- int len;
- uint8_t *buf;
- if (in->open_mode != 'r') return -1;
- buf = malloc(BUF_SIZE);
- old = bam_header_read(in);
- fp = bgzf_fdopen(fd, "w");
- bam_header_write(fp, h);
- if (in->block_offset < in->block_length) {
- bgzf_write(fp, in->uncompressed_block + in->block_offset, in->block_length - in->block_offset);
- bgzf_flush(fp);
- }
-#ifdef _USE_KNETFILE
- while ((len = knet_read(in->x.fpr, buf, BUF_SIZE)) > 0)
-#else
- while (!feof(in->file) && (len = fread(buf, 1, BUF_SIZE, in->file)) > 0)
-#endif
- fwrite(buf, 1, len, fp->x.fpw);
- free(buf);
- fp->block_offset = in->block_offset = 0;
- bgzf_close(fp);
- return 0;
-}
-
-int main_reheader(int argc, char *argv[])
-{
- bam_header_t *h;
- BGZF *in;
- if (argc != 3) {
- fprintf(stderr, "Usage: samtools reheader <in.header.sam> <in.bam>\n");
- return 1;
- }
- { // read the header
- tamFile fph = sam_open(argv[1]);
- if (fph == 0) {
- fprintf(stderr, "[%s] fail to read the header from %s.\n", __func__, argv[1]);
- return 1;
- }
- h = sam_header_read(fph);
- sam_close(fph);
- }
- in = strcmp(argv[2], "-")? bam_open(argv[2], "r") : bam_dopen(fileno(stdin), "r");
- if (in == 0) {
- fprintf(stderr, "[%s] fail to open file %s.\n", __func__, argv[2]);
- return 1;
- }
- bam_reheader(in, h, fileno(stdout));
- bgzf_close(in);
- return 0;
-}
+++ /dev/null
-#include <stdlib.h>
-#include <string.h>
-#include <stdio.h>
-#include <zlib.h>
-#include <unistd.h>
-#include "sam.h"
-
-typedef bam1_t *bam1_p;
-
-#include "khash.h"
-KHASH_SET_INIT_STR(name)
-KHASH_MAP_INIT_INT64(pos, bam1_p)
-
-#define BUFFER_SIZE 0x40000
-
-typedef struct {
- uint64_t n_checked, n_removed;
- khash_t(pos) *best_hash;
-} lib_aux_t;
-KHASH_MAP_INIT_STR(lib, lib_aux_t)
-
-typedef struct {
- int n, max;
- bam1_t **a;
-} tmp_stack_t;
-
-static inline void stack_insert(tmp_stack_t *stack, bam1_t *b)
-{
- if (stack->n == stack->max) {
- stack->max = stack->max? stack->max<<1 : 0x10000;
- stack->a = (bam1_t**)realloc(stack->a, sizeof(bam1_t*) * stack->max);
- }
- stack->a[stack->n++] = b;
-}
-
-static inline void dump_best(tmp_stack_t *stack, samfile_t *out)
-{
- int i;
- for (i = 0; i != stack->n; ++i) {
- samwrite(out, stack->a[i]);
- bam_destroy1(stack->a[i]);
- }
- stack->n = 0;
-}
-
-static void clear_del_set(khash_t(name) *del_set)
-{
- khint_t k;
- for (k = kh_begin(del_set); k < kh_end(del_set); ++k)
- if (kh_exist(del_set, k))
- free((char*)kh_key(del_set, k));
- kh_clear(name, del_set);
-}
-
-static lib_aux_t *get_aux(khash_t(lib) *aux, const char *lib)
-{
- khint_t k = kh_get(lib, aux, lib);
- if (k == kh_end(aux)) {
- int ret;
- char *p = strdup(lib);
- lib_aux_t *q;
- k = kh_put(lib, aux, p, &ret);
- q = &kh_val(aux, k);
- q->n_checked = q->n_removed = 0;
- q->best_hash = kh_init(pos);
- return q;
- } else return &kh_val(aux, k);
-}
-
-static void clear_best(khash_t(lib) *aux, int max)
-{
- khint_t k;
- for (k = kh_begin(aux); k != kh_end(aux); ++k) {
- if (kh_exist(aux, k)) {
- lib_aux_t *q = &kh_val(aux, k);
- if (kh_size(q->best_hash) >= max)
- kh_clear(pos, q->best_hash);
- }
- }
-}
-
-static inline int sum_qual(const bam1_t *b)
-{
- int i, q;
- uint8_t *qual = bam1_qual(b);
- for (i = q = 0; i < b->core.l_qseq; ++i) q += qual[i];
- return q;
-}
-
-void bam_rmdup_core(samfile_t *in, samfile_t *out)
-{
- bam1_t *b;
- int last_tid = -1, last_pos = -1;
- tmp_stack_t stack;
- khint_t k;
- khash_t(lib) *aux;
- khash_t(name) *del_set;
-
- aux = kh_init(lib);
- del_set = kh_init(name);
- b = bam_init1();
- memset(&stack, 0, sizeof(tmp_stack_t));
-
- kh_resize(name, del_set, 4 * BUFFER_SIZE);
- while (samread(in, b) >= 0) {
- bam1_core_t *c = &b->core;
- if (c->tid != last_tid || last_pos != c->pos) {
- dump_best(&stack, out); // write the result
- clear_best(aux, BUFFER_SIZE);
- if (c->tid != last_tid) {
- clear_best(aux, 0);
- if (kh_size(del_set)) { // check
- fprintf(stderr, "[bam_rmdup_core] %llu unmatched pairs\n", (long long)kh_size(del_set));
- clear_del_set(del_set);
- }
- if ((int)c->tid == -1) { // append unmapped reads
- samwrite(out, b);
- while (samread(in, b) >= 0) samwrite(out, b);
- break;
- }
- last_tid = c->tid;
- fprintf(stderr, "[bam_rmdup_core] processing reference %s...\n", in->header->target_name[c->tid]);
- }
- }
- if (!(c->flag&BAM_FPAIRED) || (c->flag&(BAM_FUNMAP|BAM_FMUNMAP)) || (c->mtid >= 0 && c->tid != c->mtid)) {
- samwrite(out, b);
- } else if (c->isize > 0) { // paired, head
- uint64_t key = (uint64_t)c->pos<<32 | c->isize;
- const char *lib;
- lib_aux_t *q;
- int ret;
- lib = bam_get_library(in->header, b);
- q = lib? get_aux(aux, lib) : get_aux(aux, "\t");
- ++q->n_checked;
- k = kh_put(pos, q->best_hash, key, &ret);
- if (ret == 0) { // found in best_hash
- bam1_t *p = kh_val(q->best_hash, k);
- ++q->n_removed;
- if (sum_qual(p) < sum_qual(b)) { // the current alignment is better; this can be accelerated in principle
- kh_put(name, del_set, strdup(bam1_qname(p)), &ret); // p will be removed
- bam_copy1(p, b); // replaced as b
- } else kh_put(name, del_set, strdup(bam1_qname(b)), &ret); // b will be removed
- if (ret == 0)
- fprintf(stderr, "[bam_rmdup_core] inconsistent BAM file for pair '%s'. Continue anyway.\n", bam1_qname(b));
- } else { // not found in best_hash
- kh_val(q->best_hash, k) = bam_dup1(b);
- stack_insert(&stack, kh_val(q->best_hash, k));
- }
- } else { // paired, tail
- k = kh_get(name, del_set, bam1_qname(b));
- if (k != kh_end(del_set)) {
- free((char*)kh_key(del_set, k));
- kh_del(name, del_set, k);
- } else samwrite(out, b);
- }
- last_pos = c->pos;
- }
-
- for (k = kh_begin(aux); k != kh_end(aux); ++k) {
- if (kh_exist(aux, k)) {
- lib_aux_t *q = &kh_val(aux, k);
- dump_best(&stack, out);
- fprintf(stderr, "[bam_rmdup_core] %lld / %lld = %.4lf in library '%s'\n", (long long)q->n_removed,
- (long long)q->n_checked, (double)q->n_removed/q->n_checked, kh_key(aux, k));
- kh_destroy(pos, q->best_hash);
- free((char*)kh_key(aux, k));
- }
- }
- kh_destroy(lib, aux);
-
- clear_del_set(del_set);
- kh_destroy(name, del_set);
- free(stack.a);
- bam_destroy1(b);
-}
-
-void bam_rmdupse_core(samfile_t *in, samfile_t *out, int force_se);
-
-int bam_rmdup(int argc, char *argv[])
-{
- int c, is_se = 0, force_se = 0;
- samfile_t *in, *out;
- while ((c = getopt(argc, argv, "sS")) >= 0) {
- switch (c) {
- case 's': is_se = 1; break;
- case 'S': force_se = is_se = 1; break;
- }
- }
- if (optind + 2 > argc) {
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: samtools rmdup [-sS] <input.srt.bam> <output.bam>\n\n");
- fprintf(stderr, "Option: -s rmdup for SE reads\n");
- fprintf(stderr, " -S treat PE reads as SE in rmdup (force -s)\n\n");
- return 1;
- }
- in = samopen(argv[optind], "rb", 0);
- out = samopen(argv[optind+1], "wb", in->header);
- if (in == 0 || out == 0) {
- fprintf(stderr, "[bam_rmdup] fail to read/write input files\n");
- return 1;
- }
- if (is_se) bam_rmdupse_core(in, out, force_se);
- else bam_rmdup_core(in, out);
- samclose(in); samclose(out);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <string.h>
+#include <stdio.h>
+#include <zlib.h>
+#include <unistd.h>
+#include "sam.h"
+
+typedef bam1_t *bam1_p;
+
+#include "khash.h"
+KHASH_SET_INIT_STR(name)
+KHASH_MAP_INIT_INT64(pos, bam1_p)
+
+#define BUFFER_SIZE 0x40000
+
+typedef struct {
+ uint64_t n_checked, n_removed;
+ khash_t(pos) *best_hash;
+} lib_aux_t;
+KHASH_MAP_INIT_STR(lib, lib_aux_t)
+
+typedef struct {
+ int n, max;
+ bam1_t **a;
+} tmp_stack_t;
+
+static inline void stack_insert(tmp_stack_t *stack, bam1_t *b)
+{
+ if (stack->n == stack->max) {
+ stack->max = stack->max? stack->max<<1 : 0x10000;
+ stack->a = (bam1_t**)realloc(stack->a, sizeof(bam1_t*) * stack->max);
+ }
+ stack->a[stack->n++] = b;
+}
+
+static inline void dump_best(tmp_stack_t *stack, samfile_t *out)
+{
+ int i;
+ for (i = 0; i != stack->n; ++i) {
+ samwrite(out, stack->a[i]);
+ bam_destroy1(stack->a[i]);
+ }
+ stack->n = 0;
+}
+
+static void clear_del_set(khash_t(name) *del_set)
+{
+ khint_t k;
+ for (k = kh_begin(del_set); k < kh_end(del_set); ++k)
+ if (kh_exist(del_set, k))
+ free((char*)kh_key(del_set, k));
+ kh_clear(name, del_set);
+}
+
+static lib_aux_t *get_aux(khash_t(lib) *aux, const char *lib)
+{
+ khint_t k = kh_get(lib, aux, lib);
+ if (k == kh_end(aux)) {
+ int ret;
+ char *p = strdup(lib);
+ lib_aux_t *q;
+ k = kh_put(lib, aux, p, &ret);
+ q = &kh_val(aux, k);
+ q->n_checked = q->n_removed = 0;
+ q->best_hash = kh_init(pos);
+ return q;
+ } else return &kh_val(aux, k);
+}
+
+static void clear_best(khash_t(lib) *aux, int max)
+{
+ khint_t k;
+ for (k = kh_begin(aux); k != kh_end(aux); ++k) {
+ if (kh_exist(aux, k)) {
+ lib_aux_t *q = &kh_val(aux, k);
+ if (kh_size(q->best_hash) >= max)
+ kh_clear(pos, q->best_hash);
+ }
+ }
+}
+
+static inline int sum_qual(const bam1_t *b)
+{
+ int i, q;
+ uint8_t *qual = bam1_qual(b);
+ for (i = q = 0; i < b->core.l_qseq; ++i) q += qual[i];
+ return q;
+}
+
+void bam_rmdup_core(samfile_t *in, samfile_t *out)
+{
+ bam1_t *b;
+ int last_tid = -1, last_pos = -1;
+ tmp_stack_t stack;
+ khint_t k;
+ khash_t(lib) *aux;
+ khash_t(name) *del_set;
+
+ aux = kh_init(lib);
+ del_set = kh_init(name);
+ b = bam_init1();
+ memset(&stack, 0, sizeof(tmp_stack_t));
+
+ kh_resize(name, del_set, 4 * BUFFER_SIZE);
+ while (samread(in, b) >= 0) {
+ bam1_core_t *c = &b->core;
+ if (c->tid != last_tid || last_pos != c->pos) {
+ dump_best(&stack, out); // write the result
+ clear_best(aux, BUFFER_SIZE);
+ if (c->tid != last_tid) {
+ clear_best(aux, 0);
+ if (kh_size(del_set)) { // check
+ fprintf(pysamerr, "[bam_rmdup_core] %llu unmatched pairs\n", (long long)kh_size(del_set));
+ clear_del_set(del_set);
+ }
+ if ((int)c->tid == -1) { // append unmapped reads
+ samwrite(out, b);
+ while (samread(in, b) >= 0) samwrite(out, b);
+ break;
+ }
+ last_tid = c->tid;
+ fprintf(pysamerr, "[bam_rmdup_core] processing reference %s...\n", in->header->target_name[c->tid]);
+ }
+ }
+ if (!(c->flag&BAM_FPAIRED) || (c->flag&(BAM_FUNMAP|BAM_FMUNMAP)) || (c->mtid >= 0 && c->tid != c->mtid)) {
+ samwrite(out, b);
+ } else if (c->isize > 0) { // paired, head
+ uint64_t key = (uint64_t)c->pos<<32 | c->isize;
+ const char *lib;
+ lib_aux_t *q;
+ int ret;
+ lib = bam_get_library(in->header, b);
+ q = lib? get_aux(aux, lib) : get_aux(aux, "\t");
+ ++q->n_checked;
+ k = kh_put(pos, q->best_hash, key, &ret);
+ if (ret == 0) { // found in best_hash
+ bam1_t *p = kh_val(q->best_hash, k);
+ ++q->n_removed;
+ if (sum_qual(p) < sum_qual(b)) { // the current alignment is better; this can be accelerated in principle
+ kh_put(name, del_set, strdup(bam1_qname(p)), &ret); // p will be removed
+ bam_copy1(p, b); // replaced as b
+ } else kh_put(name, del_set, strdup(bam1_qname(b)), &ret); // b will be removed
+ if (ret == 0)
+ fprintf(pysamerr, "[bam_rmdup_core] inconsistent BAM file for pair '%s'. Continue anyway.\n", bam1_qname(b));
+ } else { // not found in best_hash
+ kh_val(q->best_hash, k) = bam_dup1(b);
+ stack_insert(&stack, kh_val(q->best_hash, k));
+ }
+ } else { // paired, tail
+ k = kh_get(name, del_set, bam1_qname(b));
+ if (k != kh_end(del_set)) {
+ free((char*)kh_key(del_set, k));
+ kh_del(name, del_set, k);
+ } else samwrite(out, b);
+ }
+ last_pos = c->pos;
+ }
+
+ for (k = kh_begin(aux); k != kh_end(aux); ++k) {
+ if (kh_exist(aux, k)) {
+ lib_aux_t *q = &kh_val(aux, k);
+ dump_best(&stack, out);
+ fprintf(pysamerr, "[bam_rmdup_core] %lld / %lld = %.4lf in library '%s'\n", (long long)q->n_removed,
+ (long long)q->n_checked, (double)q->n_removed/q->n_checked, kh_key(aux, k));
+ kh_destroy(pos, q->best_hash);
+ free((char*)kh_key(aux, k));
+ }
+ }
+ kh_destroy(lib, aux);
+
+ clear_del_set(del_set);
+ kh_destroy(name, del_set);
+ free(stack.a);
+ bam_destroy1(b);
+}
+
+void bam_rmdupse_core(samfile_t *in, samfile_t *out, int force_se);
+
+int bam_rmdup(int argc, char *argv[])
+{
+ int c, is_se = 0, force_se = 0;
+ samfile_t *in, *out;
+ while ((c = getopt(argc, argv, "sS")) >= 0) {
+ switch (c) {
+ case 's': is_se = 1; break;
+ case 'S': force_se = is_se = 1; break;
+ }
+ }
+ if (optind + 2 > argc) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools rmdup [-sS] <input.srt.bam> <output.bam>\n\n");
+ fprintf(pysamerr, "Option: -s rmdup for SE reads\n");
+ fprintf(pysamerr, " -S treat PE reads as SE in rmdup (force -s)\n\n");
+ return 1;
+ }
+ in = samopen(argv[optind], "rb", 0);
+ out = samopen(argv[optind+1], "wb", in->header);
+ if (in == 0 || out == 0) {
+ fprintf(pysamerr, "[bam_rmdup] fail to read/write input files\n");
+ return 1;
+ }
+ if (is_se) bam_rmdupse_core(in, out, force_se);
+ else bam_rmdup_core(in, out);
+ samclose(in); samclose(out);
+ return 0;
+}
+++ /dev/null
-#include <math.h>
-#include "sam.h"
-#include "khash.h"
-#include "klist.h"
-
-#define QUEUE_CLEAR_SIZE 0x100000
-#define MAX_POS 0x7fffffff
-
-typedef struct {
- int endpos;
- uint32_t score:31, discarded:1;
- bam1_t *b;
-} elem_t, *elem_p;
-#define __free_elem(p) bam_destroy1((p)->data.b)
-KLIST_INIT(q, elem_t, __free_elem)
-typedef klist_t(q) queue_t;
-
-KHASH_MAP_INIT_INT(best, elem_p)
-typedef khash_t(best) besthash_t;
-
-typedef struct {
- uint64_t n_checked, n_removed;
- besthash_t *left, *rght;
-} lib_aux_t;
-KHASH_MAP_INIT_STR(lib, lib_aux_t)
-
-static lib_aux_t *get_aux(khash_t(lib) *aux, const char *lib)
-{
- khint_t k = kh_get(lib, aux, lib);
- if (k == kh_end(aux)) {
- int ret;
- char *p = strdup(lib);
- lib_aux_t *q;
- k = kh_put(lib, aux, p, &ret);
- q = &kh_val(aux, k);
- q->left = kh_init(best);
- q->rght = kh_init(best);
- q->n_checked = q->n_removed = 0;
- return q;
- } else return &kh_val(aux, k);
-}
-
-static inline int sum_qual(const bam1_t *b)
-{
- int i, q;
- uint8_t *qual = bam1_qual(b);
- for (i = q = 0; i < b->core.l_qseq; ++i) q += qual[i];
- return q;
-}
-
-static inline elem_t *push_queue(queue_t *queue, const bam1_t *b, int endpos, int score)
-{
- elem_t *p = kl_pushp(q, queue);
- p->discarded = 0;
- p->endpos = endpos; p->score = score;
- if (p->b == 0) p->b = bam_init1();
- bam_copy1(p->b, b);
- return p;
-}
-
-static void clear_besthash(besthash_t *h, int32_t pos)
-{
- khint_t k;
- for (k = kh_begin(h); k != kh_end(h); ++k)
- if (kh_exist(h, k) && kh_val(h, k)->endpos <= pos)
- kh_del(best, h, k);
-}
-
-static void dump_alignment(samfile_t *out, queue_t *queue, int32_t pos, khash_t(lib) *h)
-{
- if (queue->size > QUEUE_CLEAR_SIZE || pos == MAX_POS) {
- khint_t k;
- while (1) {
- elem_t *q;
- if (queue->head == queue->tail) break;
- q = &kl_val(queue->head);
- if (q->discarded) {
- q->b->data_len = 0;
- kl_shift(q, queue, 0);
- continue;
- }
- if ((q->b->core.flag&BAM_FREVERSE) && q->endpos > pos) break;
- samwrite(out, q->b);
- q->b->data_len = 0;
- kl_shift(q, queue, 0);
- }
- for (k = kh_begin(h); k != kh_end(h); ++k) {
- if (kh_exist(h, k)) {
- clear_besthash(kh_val(h, k).left, pos);
- clear_besthash(kh_val(h, k).rght, pos);
- }
- }
- }
-}
-
-void bam_rmdupse_core(samfile_t *in, samfile_t *out, int force_se)
-{
- bam1_t *b;
- queue_t *queue;
- khint_t k;
- int last_tid = -2;
- khash_t(lib) *aux;
-
- aux = kh_init(lib);
- b = bam_init1();
- queue = kl_init(q);
- while (samread(in, b) >= 0) {
- bam1_core_t *c = &b->core;
- int endpos = bam_calend(c, bam1_cigar(b));
- int score = sum_qual(b);
-
- if (last_tid != c->tid) {
- if (last_tid >= 0) dump_alignment(out, queue, MAX_POS, aux);
- last_tid = c->tid;
- } else dump_alignment(out, queue, c->pos, aux);
- if ((c->flag&BAM_FUNMAP) || ((c->flag&BAM_FPAIRED) && !force_se)) {
- push_queue(queue, b, endpos, score);
- } else {
- const char *lib;
- lib_aux_t *q;
- besthash_t *h;
- uint32_t key;
- int ret;
- lib = bam_get_library(in->header, b);
- q = lib? get_aux(aux, lib) : get_aux(aux, "\t");
- ++q->n_checked;
- h = (c->flag&BAM_FREVERSE)? q->rght : q->left;
- key = (c->flag&BAM_FREVERSE)? endpos : c->pos;
- k = kh_put(best, h, key, &ret);
- if (ret == 0) { // in the hash table
- elem_t *p = kh_val(h, k);
- ++q->n_removed;
- if (p->score < score) {
- if (c->flag&BAM_FREVERSE) { // mark "discarded" and push the queue
- p->discarded = 1;
- kh_val(h, k) = push_queue(queue, b, endpos, score);
- } else { // replace
- p->score = score; p->endpos = endpos;
- bam_copy1(p->b, b);
- }
- } // otherwise, discard the alignment
- } else kh_val(h, k) = push_queue(queue, b, endpos, score);
- }
- }
- dump_alignment(out, queue, MAX_POS, aux);
-
- for (k = kh_begin(aux); k != kh_end(aux); ++k) {
- if (kh_exist(aux, k)) {
- lib_aux_t *q = &kh_val(aux, k);
- fprintf(stderr, "[bam_rmdupse_core] %lld / %lld = %.4lf in library '%s'\n", (long long)q->n_removed,
- (long long)q->n_checked, (double)q->n_removed/q->n_checked, kh_key(aux, k));
- kh_destroy(best, q->left); kh_destroy(best, q->rght);
- free((char*)kh_key(aux, k));
- }
- }
- kh_destroy(lib, aux);
- bam_destroy1(b);
- kl_destroy(q, queue);
-}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include "sam.h"
+#include "khash.h"
+#include "klist.h"
+
+#define QUEUE_CLEAR_SIZE 0x100000
+#define MAX_POS 0x7fffffff
+
+typedef struct {
+ int endpos;
+ uint32_t score:31, discarded:1;
+ bam1_t *b;
+} elem_t, *elem_p;
+#define __free_elem(p) bam_destroy1((p)->data.b)
+KLIST_INIT(q, elem_t, __free_elem)
+typedef klist_t(q) queue_t;
+
+KHASH_MAP_INIT_INT(best, elem_p)
+typedef khash_t(best) besthash_t;
+
+typedef struct {
+ uint64_t n_checked, n_removed;
+ besthash_t *left, *rght;
+} lib_aux_t;
+KHASH_MAP_INIT_STR(lib, lib_aux_t)
+
+static lib_aux_t *get_aux(khash_t(lib) *aux, const char *lib)
+{
+ khint_t k = kh_get(lib, aux, lib);
+ if (k == kh_end(aux)) {
+ int ret;
+ char *p = strdup(lib);
+ lib_aux_t *q;
+ k = kh_put(lib, aux, p, &ret);
+ q = &kh_val(aux, k);
+ q->left = kh_init(best);
+ q->rght = kh_init(best);
+ q->n_checked = q->n_removed = 0;
+ return q;
+ } else return &kh_val(aux, k);
+}
+
+static inline int sum_qual(const bam1_t *b)
+{
+ int i, q;
+ uint8_t *qual = bam1_qual(b);
+ for (i = q = 0; i < b->core.l_qseq; ++i) q += qual[i];
+ return q;
+}
+
+static inline elem_t *push_queue(queue_t *queue, const bam1_t *b, int endpos, int score)
+{
+ elem_t *p = kl_pushp(q, queue);
+ p->discarded = 0;
+ p->endpos = endpos; p->score = score;
+ if (p->b == 0) p->b = bam_init1();
+ bam_copy1(p->b, b);
+ return p;
+}
+
+static void clear_besthash(besthash_t *h, int32_t pos)
+{
+ khint_t k;
+ for (k = kh_begin(h); k != kh_end(h); ++k)
+ if (kh_exist(h, k) && kh_val(h, k)->endpos <= pos)
+ kh_del(best, h, k);
+}
+
+static void dump_alignment(samfile_t *out, queue_t *queue, int32_t pos, khash_t(lib) *h)
+{
+ if (queue->size > QUEUE_CLEAR_SIZE || pos == MAX_POS) {
+ khint_t k;
+ while (1) {
+ elem_t *q;
+ if (queue->head == queue->tail) break;
+ q = &kl_val(queue->head);
+ if (q->discarded) {
+ q->b->data_len = 0;
+ kl_shift(q, queue, 0);
+ continue;
+ }
+ if ((q->b->core.flag&BAM_FREVERSE) && q->endpos > pos) break;
+ samwrite(out, q->b);
+ q->b->data_len = 0;
+ kl_shift(q, queue, 0);
+ }
+ for (k = kh_begin(h); k != kh_end(h); ++k) {
+ if (kh_exist(h, k)) {
+ clear_besthash(kh_val(h, k).left, pos);
+ clear_besthash(kh_val(h, k).rght, pos);
+ }
+ }
+ }
+}
+
+void bam_rmdupse_core(samfile_t *in, samfile_t *out, int force_se)
+{
+ bam1_t *b;
+ queue_t *queue;
+ khint_t k;
+ int last_tid = -2;
+ khash_t(lib) *aux;
+
+ aux = kh_init(lib);
+ b = bam_init1();
+ queue = kl_init(q);
+ while (samread(in, b) >= 0) {
+ bam1_core_t *c = &b->core;
+ int endpos = bam_calend(c, bam1_cigar(b));
+ int score = sum_qual(b);
+
+ if (last_tid != c->tid) {
+ if (last_tid >= 0) dump_alignment(out, queue, MAX_POS, aux);
+ last_tid = c->tid;
+ } else dump_alignment(out, queue, c->pos, aux);
+ if ((c->flag&BAM_FUNMAP) || ((c->flag&BAM_FPAIRED) && !force_se)) {
+ push_queue(queue, b, endpos, score);
+ } else {
+ const char *lib;
+ lib_aux_t *q;
+ besthash_t *h;
+ uint32_t key;
+ int ret;
+ lib = bam_get_library(in->header, b);
+ q = lib? get_aux(aux, lib) : get_aux(aux, "\t");
+ ++q->n_checked;
+ h = (c->flag&BAM_FREVERSE)? q->rght : q->left;
+ key = (c->flag&BAM_FREVERSE)? endpos : c->pos;
+ k = kh_put(best, h, key, &ret);
+ if (ret == 0) { // in the hash table
+ elem_t *p = kh_val(h, k);
+ ++q->n_removed;
+ if (p->score < score) {
+ if (c->flag&BAM_FREVERSE) { // mark "discarded" and push the queue
+ p->discarded = 1;
+ kh_val(h, k) = push_queue(queue, b, endpos, score);
+ } else { // replace
+ p->score = score; p->endpos = endpos;
+ bam_copy1(p->b, b);
+ }
+ } // otherwise, discard the alignment
+ } else kh_val(h, k) = push_queue(queue, b, endpos, score);
+ }
+ }
+ dump_alignment(out, queue, MAX_POS, aux);
+
+ for (k = kh_begin(aux); k != kh_end(aux); ++k) {
+ if (kh_exist(aux, k)) {
+ lib_aux_t *q = &kh_val(aux, k);
+ fprintf(pysamerr, "[bam_rmdupse_core] %lld / %lld = %.4lf in library '%s'\n", (long long)q->n_removed,
+ (long long)q->n_checked, (double)q->n_removed/q->n_checked, kh_key(aux, k));
+ kh_destroy(best, q->left); kh_destroy(best, q->rght);
+ free((char*)kh_key(aux, k));
+ }
+ }
+ kh_destroy(lib, aux);
+ bam_destroy1(b);
+ kl_destroy(q, queue);
+}
+++ /dev/null
-#include <stdlib.h>
-#include <ctype.h>
-#include <assert.h>
-#include <stdio.h>
-#include <string.h>
-#include <unistd.h>
-#include "bam.h"
-#include "ksort.h"
-
-static int g_is_by_qname = 0;
-
-static inline int strnum_cmp(const char *a, const char *b)
-{
- char *pa, *pb;
- pa = (char*)a; pb = (char*)b;
- while (*pa && *pb) {
- if (isdigit(*pa) && isdigit(*pb)) {
- long ai, bi;
- ai = strtol(pa, &pa, 10);
- bi = strtol(pb, &pb, 10);
- if (ai != bi) return ai<bi? -1 : ai>bi? 1 : 0;
- } else {
- if (*pa != *pb) break;
- ++pa; ++pb;
- }
- }
- if (*pa == *pb)
- return (pa-a) < (pb-b)? -1 : (pa-a) > (pb-b)? 1 : 0;
- return *pa<*pb? -1 : *pa>*pb? 1 : 0;
-}
-
-#define HEAP_EMPTY 0xffffffffffffffffull
-
-typedef struct {
- int i;
- uint64_t pos, idx;
- bam1_t *b;
-} heap1_t;
-
-#define __pos_cmp(a, b) ((a).pos > (b).pos || ((a).pos == (b).pos && ((a).i > (b).i || ((a).i == (b).i && (a).idx > (b).idx))))
-
-static inline int heap_lt(const heap1_t a, const heap1_t b)
-{
- if (g_is_by_qname) {
- int t;
- if (a.b == 0 || b.b == 0) return a.b == 0? 1 : 0;
- t = strnum_cmp(bam1_qname(a.b), bam1_qname(b.b));
- return (t > 0 || (t == 0 && __pos_cmp(a, b)));
- } else return __pos_cmp(a, b);
-}
-
-KSORT_INIT(heap, heap1_t, heap_lt)
-
-static void swap_header_text(bam_header_t *h1, bam_header_t *h2)
-{
- int tempi;
- char *temps;
- tempi = h1->l_text, h1->l_text = h2->l_text, h2->l_text = tempi;
- temps = h1->text, h1->text = h2->text, h2->text = temps;
-}
-
-/*!
- @abstract Merge multiple sorted BAM.
- @param is_by_qname whether to sort by query name
- @param out output BAM file name
- @param headers name of SAM file from which to copy '@' header lines,
- or NULL to copy them from the first file to be merged
- @param n number of files to be merged
- @param fn names of files to be merged
-
- @discussion Padding information may NOT correctly maintained. This
- function is NOT thread safe.
- */
-void bam_merge_core(int by_qname, const char *out, const char *headers, int n, char * const *fn, int add_RG)
-{
- bamFile fpout, *fp;
- heap1_t *heap;
- bam_header_t *hout = 0;
- bam_header_t *hheaders = NULL;
- int i, j, *RG_len = 0;
- uint64_t idx = 0;
- char **RG = 0;
-
- if (headers) {
- tamFile fpheaders = sam_open(headers);
- if (fpheaders == 0) {
- fprintf(stderr, "[bam_merge_core] Cannot open file `%s'. Continue anyway.\n", headers);
- } else {
- hheaders = sam_header_read(fpheaders);
- sam_close(fpheaders);
- }
- }
-
- g_is_by_qname = by_qname;
- fp = (bamFile*)calloc(n, sizeof(bamFile));
- heap = (heap1_t*)calloc(n, sizeof(heap1_t));
- // prepare RG tag
- if (add_RG) {
- RG = (char**)calloc(n, sizeof(void*));
- RG_len = (int*)calloc(n, sizeof(int));
- for (i = 0; i != n; ++i) {
- int l = strlen(fn[i]);
- const char *s = fn[i];
- if (l > 4 && strcmp(s + l - 4, ".bam") == 0) l -= 4;
- for (j = l - 1; j >= 0; --j) if (s[j] == '/') break;
- ++j; l -= j;
- RG[i] = calloc(l + 1, 1);
- RG_len[i] = l;
- strncpy(RG[i], s + j, l);
- }
- }
- // read the first
- for (i = 0; i != n; ++i) {
- heap1_t *h;
- bam_header_t *hin;
- fp[i] = bam_open(fn[i], "r");
- if (fp[i] == 0) {
- int j;
- fprintf(stderr, "[bam_merge_core] fail to open file %s\n", fn[i]);
- for (j = 0; j < i; ++j) bam_close(fp[j]);
- free(fp); free(heap);
- // FIXME: possible memory leak
- return;
- }
- hin = bam_header_read(fp[i]);
- if (i == 0) { // the first SAM
- hout = hin;
- if (hheaders) {
- // If the text headers to be swapped in include any @SQ headers,
- // check that they are consistent with the existing binary list
- // of reference information.
- if (hheaders->n_targets > 0) {
- if (hout->n_targets != hheaders->n_targets)
- fprintf(stderr, "[bam_merge_core] number of @SQ headers in `%s' differs from number of target sequences", headers);
- for (j = 0; j < hout->n_targets; ++j)
- if (strcmp(hout->target_name[j], hheaders->target_name[j]) != 0)
- fprintf(stderr, "[bam_merge_core] @SQ header '%s' in '%s' differs from target sequence", hheaders->target_name[j], headers);
- }
- swap_header_text(hout, hheaders);
- bam_header_destroy(hheaders);
- hheaders = NULL;
- }
- } else { // validate multiple baf
- if (hout->n_targets != hin->n_targets) {
- fprintf(stderr, "[bam_merge_core] file '%s' has different number of target sequences. Abort!\n", fn[i]);
- exit(1);
- }
- for (j = 0; j < hout->n_targets; ++j) {
- if (strcmp(hout->target_name[j], hin->target_name[j])) {
- fprintf(stderr, "[bam_merge_core] different target sequence name: '%s' != '%s' in file '%s'. Abort!\n",
- hout->target_name[j], hin->target_name[j], fn[i]);
- exit(1);
- }
- }
- bam_header_destroy(hin);
- }
- h = heap + i;
- h->i = i;
- h->b = (bam1_t*)calloc(1, sizeof(bam1_t));
- if (bam_read1(fp[i], h->b) >= 0) {
- h->pos = ((uint64_t)h->b->core.tid<<32) | (uint32_t)h->b->core.pos<<1 | bam1_strand(h->b);
- h->idx = idx++;
- }
- else h->pos = HEAP_EMPTY;
- }
- fpout = strcmp(out, "-")? bam_open(out, "w") : bam_dopen(fileno(stdout), "w");
- assert(fpout);
- bam_header_write(fpout, hout);
- bam_header_destroy(hout);
-
- ks_heapmake(heap, n, heap);
- while (heap->pos != HEAP_EMPTY) {
- bam1_t *b = heap->b;
- if (add_RG && bam_aux_get(b, "RG") == 0)
- bam_aux_append(b, "RG", 'Z', RG_len[heap->i] + 1, (uint8_t*)RG[heap->i]);
- bam_write1_core(fpout, &b->core, b->data_len, b->data);
- if ((j = bam_read1(fp[heap->i], b)) >= 0) {
- heap->pos = ((uint64_t)b->core.tid<<32) | (uint32_t)b->core.pos<<1 | bam1_strand(b);
- heap->idx = idx++;
- } else if (j == -1) {
- heap->pos = HEAP_EMPTY;
- free(heap->b->data); free(heap->b);
- heap->b = 0;
- } else fprintf(stderr, "[bam_merge_core] '%s' is truncated. Continue anyway.\n", fn[heap->i]);
- ks_heapadjust(heap, 0, n, heap);
- }
-
- if (add_RG) {
- for (i = 0; i != n; ++i) free(RG[i]);
- free(RG); free(RG_len);
- }
- for (i = 0; i != n; ++i) bam_close(fp[i]);
- bam_close(fpout);
- free(fp); free(heap);
-}
-int bam_merge(int argc, char *argv[])
-{
- int c, is_by_qname = 0, add_RG = 0;
- char *fn_headers = NULL;
-
- while ((c = getopt(argc, argv, "h:nr")) >= 0) {
- switch (c) {
- case 'r': add_RG = 1; break;
- case 'h': fn_headers = strdup(optarg); break;
- case 'n': is_by_qname = 1; break;
- }
- }
- if (optind + 2 >= argc) {
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: samtools merge [-nr] [-h inh.sam] <out.bam> <in1.bam> <in2.bam> [...]\n\n");
- fprintf(stderr, "Options: -n sort by read names\n");
- fprintf(stderr, " -r attach RG tag (inferred from file names)\n");
- fprintf(stderr, " -h FILE copy the header in FILE to <out.bam> [in1.bam]\n\n");
- fprintf(stderr, "Note: Samtools' merge does not reconstruct the @RG dictionary in the header. Users\n");
- fprintf(stderr, " must provide the correct header with -h, or uses Picard which properly maintains\n");
- fprintf(stderr, " the header dictionary in merging.\n\n");
- return 1;
- }
- bam_merge_core(is_by_qname, argv[optind], fn_headers, argc - optind - 1, argv + optind + 1, add_RG);
- free(fn_headers);
- return 0;
-}
-
-typedef bam1_t *bam1_p;
-
-static inline int bam1_lt(const bam1_p a, const bam1_p b)
-{
- if (g_is_by_qname) {
- int t = strnum_cmp(bam1_qname(a), bam1_qname(b));
- return (t < 0 || (t == 0 && (((uint64_t)a->core.tid<<32|a->core.pos) < ((uint64_t)b->core.tid<<32|b->core.pos))));
- } else return (((uint64_t)a->core.tid<<32|a->core.pos) < ((uint64_t)b->core.tid<<32|b->core.pos));
-}
-KSORT_INIT(sort, bam1_p, bam1_lt)
-
-static void sort_blocks(int n, int k, bam1_p *buf, const char *prefix, const bam_header_t *h, int is_stdout)
-{
- char *name;
- int i;
- bamFile fp;
- ks_mergesort(sort, k, buf, 0);
- name = (char*)calloc(strlen(prefix) + 20, 1);
- if (n >= 0) sprintf(name, "%s.%.4d.bam", prefix, n);
- else sprintf(name, "%s.bam", prefix);
- fp = is_stdout? bam_dopen(fileno(stdout), "w") : bam_open(name, "w");
- if (fp == 0) {
- fprintf(stderr, "[sort_blocks] fail to create file %s.\n", name);
- free(name);
- // FIXME: possible memory leak
- return;
- }
- free(name);
- bam_header_write(fp, h);
- for (i = 0; i < k; ++i)
- bam_write1_core(fp, &buf[i]->core, buf[i]->data_len, buf[i]->data);
- bam_close(fp);
-}
-
-/*!
- @abstract Sort an unsorted BAM file based on the chromosome order
- and the leftmost position of an alignment
-
- @param is_by_qname whether to sort by query name
- @param fn name of the file to be sorted
- @param prefix prefix of the output and the temporary files; upon
- sucessess, prefix.bam will be written.
- @param max_mem approxiate maximum memory (very inaccurate)
-
- @discussion It may create multiple temporary subalignment files
- and then merge them by calling bam_merge_core(). This function is
- NOT thread safe.
- */
-void bam_sort_core_ext(int is_by_qname, const char *fn, const char *prefix, size_t max_mem, int is_stdout)
-{
- int n, ret, k, i;
- size_t mem;
- bam_header_t *header;
- bamFile fp;
- bam1_t *b, **buf;
-
- g_is_by_qname = is_by_qname;
- n = k = 0; mem = 0;
- fp = strcmp(fn, "-")? bam_open(fn, "r") : bam_dopen(fileno(stdin), "r");
- if (fp == 0) {
- fprintf(stderr, "[bam_sort_core] fail to open file %s\n", fn);
- return;
- }
- header = bam_header_read(fp);
- buf = (bam1_t**)calloc(max_mem / BAM_CORE_SIZE, sizeof(bam1_t*));
- // write sub files
- for (;;) {
- if (buf[k] == 0) buf[k] = (bam1_t*)calloc(1, sizeof(bam1_t));
- b = buf[k];
- if ((ret = bam_read1(fp, b)) < 0) break;
- mem += ret;
- ++k;
- if (mem >= max_mem) {
- sort_blocks(n++, k, buf, prefix, header, 0);
- mem = 0; k = 0;
- }
- }
- if (ret != -1)
- fprintf(stderr, "[bam_sort_core] truncated file. Continue anyway.\n");
- if (n == 0) sort_blocks(-1, k, buf, prefix, header, is_stdout);
- else { // then merge
- char **fns, *fnout;
- fprintf(stderr, "[bam_sort_core] merging from %d files...\n", n+1);
- sort_blocks(n++, k, buf, prefix, header, 0);
- fnout = (char*)calloc(strlen(prefix) + 20, 1);
- if (is_stdout) sprintf(fnout, "-");
- else sprintf(fnout, "%s.bam", prefix);
- fns = (char**)calloc(n, sizeof(char*));
- for (i = 0; i < n; ++i) {
- fns[i] = (char*)calloc(strlen(prefix) + 20, 1);
- sprintf(fns[i], "%s.%.4d.bam", prefix, i);
- }
- bam_merge_core(is_by_qname, fnout, 0, n, fns, 0);
- free(fnout);
- for (i = 0; i < n; ++i) {
- unlink(fns[i]);
- free(fns[i]);
- }
- free(fns);
- }
- for (k = 0; k < max_mem / BAM_CORE_SIZE; ++k) {
- if (buf[k]) {
- free(buf[k]->data);
- free(buf[k]);
- }
- }
- free(buf);
- bam_header_destroy(header);
- bam_close(fp);
-}
-
-void bam_sort_core(int is_by_qname, const char *fn, const char *prefix, size_t max_mem)
-{
- bam_sort_core_ext(is_by_qname, fn, prefix, max_mem, 0);
-}
-
-int bam_sort(int argc, char *argv[])
-{
- size_t max_mem = 500000000;
- int c, is_by_qname = 0, is_stdout = 0;
- while ((c = getopt(argc, argv, "nom:")) >= 0) {
- switch (c) {
- case 'o': is_stdout = 1; break;
- case 'n': is_by_qname = 1; break;
- case 'm': max_mem = atol(optarg); break;
- }
- }
- if (optind + 2 > argc) {
- fprintf(stderr, "Usage: samtools sort [-on] [-m <maxMem>] <in.bam> <out.prefix>\n");
- return 1;
- }
- bam_sort_core_ext(is_by_qname, argv[optind], argv[optind+1], max_mem, is_stdout);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <ctype.h>
+#include <assert.h>
+#include <errno.h>
+#include <stdio.h>
+#include <string.h>
+#include <unistd.h>
+#include "bam.h"
+#include "ksort.h"
+
+static int g_is_by_qname = 0;
+
+static inline int strnum_cmp(const char *a, const char *b)
+{
+ char *pa, *pb;
+ pa = (char*)a; pb = (char*)b;
+ while (*pa && *pb) {
+ if (isdigit(*pa) && isdigit(*pb)) {
+ long ai, bi;
+ ai = strtol(pa, &pa, 10);
+ bi = strtol(pb, &pb, 10);
+ if (ai != bi) return ai<bi? -1 : ai>bi? 1 : 0;
+ } else {
+ if (*pa != *pb) break;
+ ++pa; ++pb;
+ }
+ }
+ if (*pa == *pb)
+ return (pa-a) < (pb-b)? -1 : (pa-a) > (pb-b)? 1 : 0;
+ return *pa<*pb? -1 : *pa>*pb? 1 : 0;
+}
+
+#define HEAP_EMPTY 0xffffffffffffffffull
+
+typedef struct {
+ int i;
+ uint64_t pos, idx;
+ bam1_t *b;
+} heap1_t;
+
+#define __pos_cmp(a, b) ((a).pos > (b).pos || ((a).pos == (b).pos && ((a).i > (b).i || ((a).i == (b).i && (a).idx > (b).idx))))
+
+static inline int heap_lt(const heap1_t a, const heap1_t b)
+{
+ if (g_is_by_qname) {
+ int t;
+ if (a.b == 0 || b.b == 0) return a.b == 0? 1 : 0;
+ t = strnum_cmp(bam1_qname(a.b), bam1_qname(b.b));
+ return (t > 0 || (t == 0 && __pos_cmp(a, b)));
+ } else return __pos_cmp(a, b);
+}
+
+KSORT_INIT(heap, heap1_t, heap_lt)
+
+static void swap_header_targets(bam_header_t *h1, bam_header_t *h2)
+{
+ bam_header_t t;
+ t.n_targets = h1->n_targets, h1->n_targets = h2->n_targets, h2->n_targets = t.n_targets;
+ t.target_name = h1->target_name, h1->target_name = h2->target_name, h2->target_name = t.target_name;
+ t.target_len = h1->target_len, h1->target_len = h2->target_len, h2->target_len = t.target_len;
+}
+
+static void swap_header_text(bam_header_t *h1, bam_header_t *h2)
+{
+ int tempi;
+ char *temps;
+ tempi = h1->l_text, h1->l_text = h2->l_text, h2->l_text = tempi;
+ temps = h1->text, h1->text = h2->text, h2->text = temps;
+}
+
+#define MERGE_RG 1
+#define MERGE_UNCOMP 2
+#define MERGE_LEVEL1 4
+#define MERGE_FORCE 8
+
+/*!
+ @abstract Merge multiple sorted BAM.
+ @param is_by_qname whether to sort by query name
+ @param out output BAM file name
+ @param headers name of SAM file from which to copy '@' header lines,
+ or NULL to copy them from the first file to be merged
+ @param n number of files to be merged
+ @param fn names of files to be merged
+
+ @discussion Padding information may NOT correctly maintained. This
+ function is NOT thread safe.
+ */
+int bam_merge_core(int by_qname, const char *out, const char *headers, int n, char * const *fn,
+ int flag, const char *reg)
+{
+ bamFile fpout, *fp;
+ heap1_t *heap;
+ bam_header_t *hout = 0;
+ bam_header_t *hheaders = NULL;
+ int i, j, *RG_len = 0;
+ uint64_t idx = 0;
+ char **RG = 0;
+ bam_iter_t *iter = 0;
+
+ if (headers) {
+ tamFile fpheaders = sam_open(headers);
+ if (fpheaders == 0) {
+ const char *message = strerror(errno);
+ fprintf(pysamerr, "[bam_merge_core] cannot open '%s': %s\n", headers, message);
+ return -1;
+ }
+ hheaders = sam_header_read(fpheaders);
+ sam_close(fpheaders);
+ }
+
+ g_is_by_qname = by_qname;
+ fp = (bamFile*)calloc(n, sizeof(bamFile));
+ heap = (heap1_t*)calloc(n, sizeof(heap1_t));
+ iter = (bam_iter_t*)calloc(n, sizeof(bam_iter_t));
+ // prepare RG tag
+ if (flag & MERGE_RG) {
+ RG = (char**)calloc(n, sizeof(void*));
+ RG_len = (int*)calloc(n, sizeof(int));
+ for (i = 0; i != n; ++i) {
+ int l = strlen(fn[i]);
+ const char *s = fn[i];
+ if (l > 4 && strcmp(s + l - 4, ".bam") == 0) l -= 4;
+ for (j = l - 1; j >= 0; --j) if (s[j] == '/') break;
+ ++j; l -= j;
+ RG[i] = calloc(l + 1, 1);
+ RG_len[i] = l;
+ strncpy(RG[i], s + j, l);
+ }
+ }
+ // read the first
+ for (i = 0; i != n; ++i) {
+ bam_header_t *hin;
+ fp[i] = bam_open(fn[i], "r");
+ if (fp[i] == 0) {
+ int j;
+ fprintf(pysamerr, "[bam_merge_core] fail to open file %s\n", fn[i]);
+ for (j = 0; j < i; ++j) bam_close(fp[j]);
+ free(fp); free(heap);
+ // FIXME: possible memory leak
+ return -1;
+ }
+ hin = bam_header_read(fp[i]);
+ if (i == 0) { // the first BAM
+ hout = hin;
+ } else { // validate multiple baf
+ int min_n_targets = hout->n_targets;
+ if (hin->n_targets < min_n_targets) min_n_targets = hin->n_targets;
+
+ for (j = 0; j < min_n_targets; ++j)
+ if (strcmp(hout->target_name[j], hin->target_name[j]) != 0) {
+ fprintf(pysamerr, "[bam_merge_core] different target sequence name: '%s' != '%s' in file '%s'\n",
+ hout->target_name[j], hin->target_name[j], fn[i]);
+ return -1;
+ }
+
+ // If this input file has additional target reference sequences,
+ // add them to the headers to be output
+ if (hin->n_targets > hout->n_targets) {
+ swap_header_targets(hout, hin);
+ // FIXME Possibly we should also create @SQ text headers
+ // for the newly added reference sequences
+ }
+
+ bam_header_destroy(hin);
+ }
+ }
+
+ if (hheaders) {
+ // If the text headers to be swapped in include any @SQ headers,
+ // check that they are consistent with the existing binary list
+ // of reference information.
+ if (hheaders->n_targets > 0) {
+ if (hout->n_targets != hheaders->n_targets) {
+ fprintf(pysamerr, "[bam_merge_core] number of @SQ headers in '%s' differs from number of target sequences\n", headers);
+ if (!reg) return -1;
+ }
+ for (j = 0; j < hout->n_targets; ++j)
+ if (strcmp(hout->target_name[j], hheaders->target_name[j]) != 0) {
+ fprintf(pysamerr, "[bam_merge_core] @SQ header '%s' in '%s' differs from target sequence\n", hheaders->target_name[j], headers);
+ if (!reg) return -1;
+ }
+ }
+
+ swap_header_text(hout, hheaders);
+ bam_header_destroy(hheaders);
+ }
+
+ if (reg) {
+ int tid, beg, end;
+ if (bam_parse_region(hout, reg, &tid, &beg, &end) < 0) {
+ fprintf(pysamerr, "[%s] Malformated region string or undefined reference name\n", __func__);
+ return -1;
+ }
+ for (i = 0; i < n; ++i) {
+ bam_index_t *idx;
+ idx = bam_index_load(fn[i]);
+ iter[i] = bam_iter_query(idx, tid, beg, end);
+ bam_index_destroy(idx);
+ }
+ }
+
+ for (i = 0; i < n; ++i) {
+ heap1_t *h = heap + i;
+ h->i = i;
+ h->b = (bam1_t*)calloc(1, sizeof(bam1_t));
+ if (bam_iter_read(fp[i], iter[i], h->b) >= 0) {
+ h->pos = ((uint64_t)h->b->core.tid<<32) | (uint32_t)((int32_t)h->b->core.pos+1)<<1 | bam1_strand(h->b);
+ h->idx = idx++;
+ }
+ else h->pos = HEAP_EMPTY;
+ }
+ if (flag & MERGE_UNCOMP) fpout = strcmp(out, "-")? bam_open(out, "wu") : bam_dopen(fileno(stdout), "wu");
+ else if (flag & MERGE_LEVEL1) fpout = strcmp(out, "-")? bam_open(out, "w1") : bam_dopen(fileno(stdout), "w1");
+ else fpout = strcmp(out, "-")? bam_open(out, "w") : bam_dopen(fileno(stdout), "w");
+ if (fpout == 0) {
+ fprintf(pysamerr, "[%s] fail to create the output file.\n", __func__);
+ return -1;
+ }
+ bam_header_write(fpout, hout);
+ bam_header_destroy(hout);
+
+ ks_heapmake(heap, n, heap);
+ while (heap->pos != HEAP_EMPTY) {
+ bam1_t *b = heap->b;
+ if (flag & MERGE_RG) {
+ uint8_t *rg = bam_aux_get(b, "RG");
+ if (rg) bam_aux_del(b, rg);
+ bam_aux_append(b, "RG", 'Z', RG_len[heap->i] + 1, (uint8_t*)RG[heap->i]);
+ }
+ bam_write1_core(fpout, &b->core, b->data_len, b->data);
+ if ((j = bam_iter_read(fp[heap->i], iter[heap->i], b)) >= 0) {
+ heap->pos = ((uint64_t)b->core.tid<<32) | (uint32_t)((int)b->core.pos+1)<<1 | bam1_strand(b);
+ heap->idx = idx++;
+ } else if (j == -1) {
+ heap->pos = HEAP_EMPTY;
+ free(heap->b->data); free(heap->b);
+ heap->b = 0;
+ } else fprintf(pysamerr, "[bam_merge_core] '%s' is truncated. Continue anyway.\n", fn[heap->i]);
+ ks_heapadjust(heap, 0, n, heap);
+ }
+
+ if (flag & MERGE_RG) {
+ for (i = 0; i != n; ++i) free(RG[i]);
+ free(RG); free(RG_len);
+ }
+ for (i = 0; i != n; ++i) {
+ bam_iter_destroy(iter[i]);
+ bam_close(fp[i]);
+ }
+ bam_close(fpout);
+ free(fp); free(heap); free(iter);
+ return 0;
+}
+
+int bam_merge(int argc, char *argv[])
+{
+ int c, is_by_qname = 0, flag = 0, ret = 0;
+ char *fn_headers = NULL, *reg = 0;
+
+ while ((c = getopt(argc, argv, "h:nru1R:f")) >= 0) {
+ switch (c) {
+ case 'r': flag |= MERGE_RG; break;
+ case 'f': flag |= MERGE_FORCE; break;
+ case 'h': fn_headers = strdup(optarg); break;
+ case 'n': is_by_qname = 1; break;
+ case '1': flag |= MERGE_LEVEL1; break;
+ case 'u': flag |= MERGE_UNCOMP; break;
+ case 'R': reg = strdup(optarg); break;
+ }
+ }
+ if (optind + 2 >= argc) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools merge [-nr] [-h inh.sam] <out.bam> <in1.bam> <in2.bam> [...]\n\n");
+ fprintf(pysamerr, "Options: -n sort by read names\n");
+ fprintf(pysamerr, " -r attach RG tag (inferred from file names)\n");
+ fprintf(pysamerr, " -u uncompressed BAM output\n");
+ fprintf(pysamerr, " -f overwrite the output BAM if exist\n");
+ fprintf(pysamerr, " -1 compress level 1\n");
+ fprintf(pysamerr, " -R STR merge file in the specified region STR [all]\n");
+ fprintf(pysamerr, " -h FILE copy the header in FILE to <out.bam> [in1.bam]\n\n");
+ fprintf(pysamerr, "Note: Samtools' merge does not reconstruct the @RG dictionary in the header. Users\n");
+ fprintf(pysamerr, " must provide the correct header with -h, or uses Picard which properly maintains\n");
+ fprintf(pysamerr, " the header dictionary in merging.\n\n");
+ return 1;
+ }
+ if (!(flag & MERGE_FORCE) && strcmp(argv[optind], "-")) {
+ FILE *fp = fopen(argv[optind], "rb");
+ if (fp != NULL) {
+ fclose(fp);
+ fprintf(pysamerr, "[%s] File '%s' exists. Please apply '-f' to overwrite. Abort.\n", __func__, argv[optind]);
+ return 1;
+ }
+ }
+ if (bam_merge_core(is_by_qname, argv[optind], fn_headers, argc - optind - 1, argv + optind + 1, flag, reg) < 0) ret = 1;
+ free(reg);
+ free(fn_headers);
+ return ret;
+}
+
+typedef bam1_t *bam1_p;
+
+static inline int bam1_lt(const bam1_p a, const bam1_p b)
+{
+ if (g_is_by_qname) {
+ int t = strnum_cmp(bam1_qname(a), bam1_qname(b));
+ return (t < 0 || (t == 0 && (((uint64_t)a->core.tid<<32|(a->core.pos+1)) < ((uint64_t)b->core.tid<<32|(b->core.pos+1)))));
+ } else return (((uint64_t)a->core.tid<<32|(a->core.pos+1)) < ((uint64_t)b->core.tid<<32|(b->core.pos+1)));
+}
+KSORT_INIT(sort, bam1_p, bam1_lt)
+
+static void sort_blocks(int n, int k, bam1_p *buf, const char *prefix, const bam_header_t *h, int is_stdout)
+{
+ char *name, mode[3];
+ int i;
+ bamFile fp;
+ ks_mergesort(sort, k, buf, 0);
+ name = (char*)calloc(strlen(prefix) + 20, 1);
+ if (n >= 0) {
+ sprintf(name, "%s.%.4d.bam", prefix, n);
+ strcpy(mode, "w1");
+ } else {
+ sprintf(name, "%s.bam", prefix);
+ strcpy(mode, "w");
+ }
+ fp = is_stdout? bam_dopen(fileno(stdout), mode) : bam_open(name, mode);
+ if (fp == 0) {
+ fprintf(pysamerr, "[sort_blocks] fail to create file %s.\n", name);
+ free(name);
+ // FIXME: possible memory leak
+ return;
+ }
+ free(name);
+ bam_header_write(fp, h);
+ for (i = 0; i < k; ++i)
+ bam_write1_core(fp, &buf[i]->core, buf[i]->data_len, buf[i]->data);
+ bam_close(fp);
+}
+
+/*!
+ @abstract Sort an unsorted BAM file based on the chromosome order
+ and the leftmost position of an alignment
+
+ @param is_by_qname whether to sort by query name
+ @param fn name of the file to be sorted
+ @param prefix prefix of the output and the temporary files; upon
+ sucessess, prefix.bam will be written.
+ @param max_mem approxiate maximum memory (very inaccurate)
+
+ @discussion It may create multiple temporary subalignment files
+ and then merge them by calling bam_merge_core(). This function is
+ NOT thread safe.
+ */
+void bam_sort_core_ext(int is_by_qname, const char *fn, const char *prefix, size_t max_mem, int is_stdout)
+{
+ int n, ret, k, i;
+ size_t mem;
+ bam_header_t *header;
+ bamFile fp;
+ bam1_t *b, **buf;
+
+ g_is_by_qname = is_by_qname;
+ n = k = 0; mem = 0;
+ fp = strcmp(fn, "-")? bam_open(fn, "r") : bam_dopen(fileno(stdin), "r");
+ if (fp == 0) {
+ fprintf(pysamerr, "[bam_sort_core] fail to open file %s\n", fn);
+ return;
+ }
+ header = bam_header_read(fp);
+ buf = (bam1_t**)calloc(max_mem / BAM_CORE_SIZE, sizeof(bam1_t*));
+ // write sub files
+ for (;;) {
+ if (buf[k] == 0) buf[k] = (bam1_t*)calloc(1, sizeof(bam1_t));
+ b = buf[k];
+ if ((ret = bam_read1(fp, b)) < 0) break;
+ mem += ret;
+ ++k;
+ if (mem >= max_mem) {
+ sort_blocks(n++, k, buf, prefix, header, 0);
+ mem = 0; k = 0;
+ }
+ }
+ if (ret != -1)
+ fprintf(pysamerr, "[bam_sort_core] truncated file. Continue anyway.\n");
+ if (n == 0) sort_blocks(-1, k, buf, prefix, header, is_stdout);
+ else { // then merge
+ char **fns, *fnout;
+ fprintf(pysamerr, "[bam_sort_core] merging from %d files...\n", n+1);
+ sort_blocks(n++, k, buf, prefix, header, 0);
+ fnout = (char*)calloc(strlen(prefix) + 20, 1);
+ if (is_stdout) sprintf(fnout, "-");
+ else sprintf(fnout, "%s.bam", prefix);
+ fns = (char**)calloc(n, sizeof(char*));
+ for (i = 0; i < n; ++i) {
+ fns[i] = (char*)calloc(strlen(prefix) + 20, 1);
+ sprintf(fns[i], "%s.%.4d.bam", prefix, i);
+ }
+ bam_merge_core(is_by_qname, fnout, 0, n, fns, 0, 0);
+ free(fnout);
+ for (i = 0; i < n; ++i) {
+ unlink(fns[i]);
+ free(fns[i]);
+ }
+ free(fns);
+ }
+ for (k = 0; k < max_mem / BAM_CORE_SIZE; ++k) {
+ if (buf[k]) {
+ free(buf[k]->data);
+ free(buf[k]);
+ }
+ }
+ free(buf);
+ bam_header_destroy(header);
+ bam_close(fp);
+}
+
+void bam_sort_core(int is_by_qname, const char *fn, const char *prefix, size_t max_mem)
+{
+ bam_sort_core_ext(is_by_qname, fn, prefix, max_mem, 0);
+}
+
+int bam_sort(int argc, char *argv[])
+{
+ size_t max_mem = 500000000;
+ int c, is_by_qname = 0, is_stdout = 0;
+ while ((c = getopt(argc, argv, "nom:")) >= 0) {
+ switch (c) {
+ case 'o': is_stdout = 1; break;
+ case 'n': is_by_qname = 1; break;
+ case 'm': max_mem = atol(optarg); break;
+ }
+ }
+ if (optind + 2 > argc) {
+ fprintf(pysamerr, "Usage: samtools sort [-on] [-m <maxMem>] <in.bam> <out.prefix>\n");
+ return 1;
+ }
+ bam_sort_core_ext(is_by_qname, argv[optind], argv[optind+1], max_mem, is_stdout);
+ return 0;
+}
+++ /dev/null
-#include <unistd.h>
-#include <assert.h>
-#include "bam.h"
-
-typedef struct {
- long long n_reads, n_mapped, n_pair_all, n_pair_map, n_pair_good;
- long long n_sgltn, n_read1, n_read2;
- long long n_qcfail, n_dup;
- long long n_diffchr, n_diffhigh;
-} bam_flagstat_t;
-
-#define flagstat_loop(s, c) do { \
- ++(s)->n_reads; \
- if ((c)->flag & BAM_FPAIRED) { \
- ++(s)->n_pair_all; \
- if ((c)->flag & BAM_FPROPER_PAIR) ++(s)->n_pair_good; \
- if ((c)->flag & BAM_FREAD1) ++(s)->n_read1; \
- if ((c)->flag & BAM_FREAD2) ++(s)->n_read2; \
- if (((c)->flag & BAM_FMUNMAP) && !((c)->flag & BAM_FUNMAP)) ++(s)->n_sgltn; \
- if (!((c)->flag & BAM_FUNMAP) && !((c)->flag & BAM_FMUNMAP)) { \
- ++(s)->n_pair_map; \
- if ((c)->mtid != (c)->tid) { \
- ++(s)->n_diffchr; \
- if ((c)->qual >= 5) ++(s)->n_diffhigh; \
- } \
- } \
- } \
- if (!((c)->flag & BAM_FUNMAP)) ++(s)->n_mapped; \
- if ((c)->flag & BAM_FQCFAIL) ++(s)->n_qcfail; \
- if ((c)->flag & BAM_FDUP) ++(s)->n_dup; \
- } while (0)
-
-bam_flagstat_t *bam_flagstat_core(bamFile fp)
-{
- bam_flagstat_t *s;
- bam1_t *b;
- bam1_core_t *c;
- int ret;
- s = (bam_flagstat_t*)calloc(1, sizeof(bam_flagstat_t));
- b = bam_init1();
- c = &b->core;
- while ((ret = bam_read1(fp, b)) >= 0)
- flagstat_loop(s, c);
- bam_destroy1(b);
- if (ret != -1)
- fprintf(stderr, "[bam_flagstat_core] Truncated file? Continue anyway.\n");
- return s;
-}
-int bam_flagstat(int argc, char *argv[])
-{
- bamFile fp;
- bam_header_t *header;
- bam_flagstat_t *s;
- if (argc == optind) {
- fprintf(stderr, "Usage: samtools flagstat <in.bam>\n");
- return 1;
- }
- fp = strcmp(argv[optind], "-")? bam_open(argv[optind], "r") : bam_dopen(fileno(stdin), "r");
- assert(fp);
- header = bam_header_read(fp);
- s = bam_flagstat_core(fp);
- printf("%lld in total\n", s->n_reads);
- printf("%lld QC failure\n", s->n_qcfail);
- printf("%lld duplicates\n", s->n_dup);
- printf("%lld mapped (%.2f%%)\n", s->n_mapped, (float)s->n_mapped / s->n_reads * 100.0);
- printf("%lld paired in sequencing\n", s->n_pair_all);
- printf("%lld read1\n", s->n_read1);
- printf("%lld read2\n", s->n_read2);
- printf("%lld properly paired (%.2f%%)\n", s->n_pair_good, (float)s->n_pair_good / s->n_pair_all * 100.0);
- printf("%lld with itself and mate mapped\n", s->n_pair_map);
- printf("%lld singletons (%.2f%%)\n", s->n_sgltn, (float)s->n_sgltn / s->n_pair_all * 100.0);
- printf("%lld with mate mapped to a different chr\n", s->n_diffchr);
- printf("%lld with mate mapped to a different chr (mapQ>=5)\n", s->n_diffhigh);
- free(s);
- bam_header_destroy(header);
- bam_close(fp);
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <unistd.h>
+#include <assert.h>
+#include "bam.h"
+
+typedef struct {
+ long long n_reads[2], n_mapped[2], n_pair_all[2], n_pair_map[2], n_pair_good[2];
+ long long n_sgltn[2], n_read1[2], n_read2[2];
+ long long n_dup[2];
+ long long n_diffchr[2], n_diffhigh[2];
+} bam_flagstat_t;
+
+#define flagstat_loop(s, c) do { \
+ int w = ((c)->flag & BAM_FQCFAIL)? 1 : 0; \
+ ++(s)->n_reads[w]; \
+ if ((c)->flag & BAM_FPAIRED) { \
+ ++(s)->n_pair_all[w]; \
+ if ((c)->flag & BAM_FPROPER_PAIR) ++(s)->n_pair_good[w]; \
+ if ((c)->flag & BAM_FREAD1) ++(s)->n_read1[w]; \
+ if ((c)->flag & BAM_FREAD2) ++(s)->n_read2[w]; \
+ if (((c)->flag & BAM_FMUNMAP) && !((c)->flag & BAM_FUNMAP)) ++(s)->n_sgltn[w]; \
+ if (!((c)->flag & BAM_FUNMAP) && !((c)->flag & BAM_FMUNMAP)) { \
+ ++(s)->n_pair_map[w]; \
+ if ((c)->mtid != (c)->tid) { \
+ ++(s)->n_diffchr[w]; \
+ if ((c)->qual >= 5) ++(s)->n_diffhigh[w]; \
+ } \
+ } \
+ } \
+ if (!((c)->flag & BAM_FUNMAP)) ++(s)->n_mapped[w]; \
+ if ((c)->flag & BAM_FDUP) ++(s)->n_dup[w]; \
+ } while (0)
+
+bam_flagstat_t *bam_flagstat_core(bamFile fp)
+{
+ bam_flagstat_t *s;
+ bam1_t *b;
+ bam1_core_t *c;
+ int ret;
+ s = (bam_flagstat_t*)calloc(1, sizeof(bam_flagstat_t));
+ b = bam_init1();
+ c = &b->core;
+ while ((ret = bam_read1(fp, b)) >= 0)
+ flagstat_loop(s, c);
+ bam_destroy1(b);
+ if (ret != -1)
+ fprintf(pysamerr, "[bam_flagstat_core] Truncated file? Continue anyway.\n");
+ return s;
+}
+int bam_flagstat(int argc, char *argv[])
+{
+ bamFile fp;
+ bam_header_t *header;
+ bam_flagstat_t *s;
+ if (argc == optind) {
+ fprintf(pysamerr, "Usage: samtools flagstat <in.bam>\n");
+ return 1;
+ }
+ fp = strcmp(argv[optind], "-")? bam_open(argv[optind], "r") : bam_dopen(fileno(stdin), "r");
+ assert(fp);
+ header = bam_header_read(fp);
+ s = bam_flagstat_core(fp);
+ printf("%lld + %lld in total (QC-passed reads + QC-failed reads)\n", s->n_reads[0], s->n_reads[1]);
+ printf("%lld + %lld duplicates\n", s->n_dup[0], s->n_dup[1]);
+ printf("%lld + %lld mapped (%.2f%%:%.2f%%)\n", s->n_mapped[0], s->n_mapped[1], (float)s->n_mapped[0] / s->n_reads[0] * 100.0, (float)s->n_mapped[1] / s->n_reads[1] * 100.0);
+ printf("%lld + %lld paired in sequencing\n", s->n_pair_all[0], s->n_pair_all[1]);
+ printf("%lld + %lld read1\n", s->n_read1[0], s->n_read1[1]);
+ printf("%lld + %lld read2\n", s->n_read2[0], s->n_read2[1]);
+ printf("%lld + %lld properly paired (%.2f%%:%.2f%%)\n", s->n_pair_good[0], s->n_pair_good[1], (float)s->n_pair_good[0] / s->n_pair_all[0] * 100.0, (float)s->n_pair_good[1] / s->n_pair_all[1] * 100.0);
+ printf("%lld + %lld with itself and mate mapped\n", s->n_pair_map[0], s->n_pair_map[1]);
+ printf("%lld + %lld singletons (%.2f%%:%.2f%%)\n", s->n_sgltn[0], s->n_sgltn[1], (float)s->n_sgltn[0] / s->n_pair_all[0] * 100.0, (float)s->n_sgltn[1] / s->n_pair_all[1] * 100.0);
+ printf("%lld + %lld with mate mapped to a different chr\n", s->n_diffchr[0], s->n_diffchr[1]);
+ printf("%lld + %lld with mate mapped to a different chr (mapQ>=5)\n", s->n_diffhigh[0], s->n_diffhigh[1]);
+ free(s);
+ bam_header_destroy(header);
+ bam_close(fp);
+ return 0;
+}
+++ /dev/null
-#undef _HAVE_CURSES
-
-#if _CURSES_LIB == 0
-#elif _CURSES_LIB == 1
-#include <curses.h>
-#ifndef NCURSES_VERSION
-#warning "_CURSES_LIB=1 but NCURSES_VERSION not defined; tview is NOT compiled"
-#else
-#define _HAVE_CURSES
-#endif
-#elif _CURSES_LIB == 2
-#include <xcurses.h>
-#define _HAVE_CURSES
-#else
-#warning "_CURSES_LIB is not 0, 1 or 2; tview is NOT compiled"
-#endif
-
-#ifdef _HAVE_CURSES
-#include <ctype.h>
-#include <assert.h>
-#include <string.h>
-#include "bam.h"
-#include "faidx.h"
-#include "bam_maqcns.h"
-
-char bam_aux_getCEi(bam1_t *b, int i);
-char bam_aux_getCSi(bam1_t *b, int i);
-char bam_aux_getCQi(bam1_t *b, int i);
-
-#define TV_MIN_ALNROW 2
-#define TV_MAX_GOTO 40
-#define TV_LOW_MAPQ 10
-
-#define TV_COLOR_MAPQ 0
-#define TV_COLOR_BASEQ 1
-#define TV_COLOR_NUCL 2
-#define TV_COLOR_COL 3
-#define TV_COLOR_COLQ 4
-
-#define TV_BASE_NUCL 0
-#define TV_BASE_COLOR_SPACE 1
-
-typedef struct {
- int mrow, mcol;
- WINDOW *wgoto, *whelp;
-
- bam_index_t *idx;
- bam_lplbuf_t *lplbuf;
- bam_header_t *header;
- bamFile fp;
- int curr_tid, left_pos;
- faidx_t *fai;
- bam_maqcns_t *bmc;
-
- int ccol, last_pos, row_shift, base_for, color_for, is_dot, l_ref, ins, no_skip, show_name;
- char *ref;
-} tview_t;
-
-int tv_pl_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pl, void *data)
-{
- tview_t *tv = (tview_t*)data;
- int i, j, c, rb, attr, max_ins = 0;
- uint32_t call = 0;
- if (pos < tv->left_pos || tv->ccol > tv->mcol) return 0; // out of screen
- // print referece
- rb = (tv->ref && pos - tv->left_pos < tv->l_ref)? tv->ref[pos - tv->left_pos] : 'N';
- for (i = tv->last_pos + 1; i < pos; ++i) {
- if (i%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", i+1);
- c = tv->ref? tv->ref[i - tv->left_pos] : 'N';
- mvaddch(1, tv->ccol++, c);
- }
- if (pos%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", pos+1);
- // print consensus
- call = bam_maqcns_call(n, pl, tv->bmc);
- attr = A_UNDERLINE;
- c = ",ACMGRSVTWYHKDBN"[call>>28&0xf];
- i = (call>>8&0xff)/10+1;
- if (i > 4) i = 4;
- attr |= COLOR_PAIR(i);
- if (c == toupper(rb)) c = '.';
- attron(attr);
- mvaddch(2, tv->ccol, c);
- attroff(attr);
- if(tv->ins) {
- // calculate maximum insert
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- if (p->indel > 0 && max_ins < p->indel) max_ins = p->indel;
- }
- }
- // core loop
- for (j = 0; j <= max_ins; ++j) {
- for (i = 0; i < n; ++i) {
- const bam_pileup1_t *p = pl + i;
- int row = TV_MIN_ALNROW + p->level - tv->row_shift;
- if (j == 0) {
- if (!p->is_del) {
- if (tv->base_for == TV_BASE_COLOR_SPACE &&
- (c = bam_aux_getCSi(p->b, p->qpos))) {
- c = bam_aux_getCSi(p->b, p->qpos);
- // assume that if we found one color, we will be able to get the color error
- if (tv->is_dot && '-' == bam_aux_getCEi(p->b, p->qpos)) c = bam1_strand(p->b)? ',' : '.';
- } else {
- if (tv->show_name) {
- char *name = bam1_qname(p->b);
- c = (p->qpos + 1 >= p->b->core.l_qname)? ' ' : name[p->qpos];
- } else {
- c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos)];
- if (tv->is_dot && toupper(c) == toupper(rb)) c = bam1_strand(p->b)? ',' : '.';
- }
- }
- } else c = '*';
- } else { // padding
- if (j > p->indel) c = '*';
- else { // insertion
- if (tv->base_for == TV_BASE_NUCL) {
- if (tv->show_name) {
- char *name = bam1_qname(p->b);
- c = (p->qpos + j + 1 >= p->b->core.l_qname)? ' ' : name[p->qpos + j];
- } else {
- c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos + j)];
- if (j == 0 && tv->is_dot && toupper(c) == toupper(rb)) c = bam1_strand(p->b)? ',' : '.';
- }
- } else {
- c = bam_aux_getCSi(p->b, p->qpos + j);
- if (tv->is_dot && '-' == bam_aux_getCEi(p->b, p->qpos + j)) c = bam1_strand(p->b)? ',' : '.';
- }
- }
- }
- if (row > TV_MIN_ALNROW && row < tv->mrow) {
- int x;
- attr = 0;
- if (((p->b->core.flag&BAM_FPAIRED) && !(p->b->core.flag&BAM_FPROPER_PAIR))
- || (p->b->core.flag & BAM_FSECONDARY)) attr |= A_UNDERLINE;
- if (tv->color_for == TV_COLOR_BASEQ) {
- x = bam1_qual(p->b)[p->qpos]/10 + 1;
- if (x > 4) x = 4;
- attr |= COLOR_PAIR(x);
- } else if (tv->color_for == TV_COLOR_MAPQ) {
- x = p->b->core.qual/10 + 1;
- if (x > 4) x = 4;
- attr |= COLOR_PAIR(x);
- } else if (tv->color_for == TV_COLOR_NUCL) {
- x = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos)] + 5;
- attr |= COLOR_PAIR(x);
- } else if(tv->color_for == TV_COLOR_COL) {
- x = 0;
- switch(bam_aux_getCSi(p->b, p->qpos)) {
- case '0': x = 0; break;
- case '1': x = 1; break;
- case '2': x = 2; break;
- case '3': x = 3; break;
- case '4': x = 4; break;
- default: x = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos)]; break;
- }
- x+=5;
- attr |= COLOR_PAIR(x);
- } else if(tv->color_for == TV_COLOR_COLQ) {
- x = bam_aux_getCQi(p->b, p->qpos);
- if(0 == x) x = bam1_qual(p->b)[p->qpos];
- x = x/10 + 1;
- if (x > 4) x = 4;
- attr |= COLOR_PAIR(x);
- }
- attron(attr);
- mvaddch(row, tv->ccol, bam1_strand(p->b)? tolower(c) : toupper(c));
- attroff(attr);
- }
- }
- c = j? '*' : rb;
- if (c == '*') {
- attr = COLOR_PAIR(8);
- attron(attr);
- mvaddch(1, tv->ccol++, c);
- attroff(attr);
- } else mvaddch(1, tv->ccol++, c);
- }
- tv->last_pos = pos;
- return 0;
-}
-
-tview_t *tv_init(const char *fn, const char *fn_fa)
-{
- tview_t *tv = (tview_t*)calloc(1, sizeof(tview_t));
- tv->is_dot = 1;
- tv->idx = bam_index_load(fn);
- if (tv->idx == 0) exit(1);
- tv->fp = bam_open(fn, "r");
- bgzf_set_cache_size(tv->fp, 8 * 1024 *1024);
- assert(tv->fp);
- tv->header = bam_header_read(tv->fp);
- tv->lplbuf = bam_lplbuf_init(tv_pl_func, tv);
- if (fn_fa) tv->fai = fai_load(fn_fa);
- tv->bmc = bam_maqcns_init();
- tv->ins = 1;
- bam_maqcns_prepare(tv->bmc);
-
- initscr();
- keypad(stdscr, TRUE);
- clear();
- noecho();
- cbreak();
- tv->mrow = 24; tv->mcol = 80;
- getmaxyx(stdscr, tv->mrow, tv->mcol);
- tv->wgoto = newwin(3, TV_MAX_GOTO + 10, 10, 5);
- tv->whelp = newwin(29, 40, 5, 5);
- tv->color_for = TV_COLOR_MAPQ;
- start_color();
- init_pair(1, COLOR_BLUE, COLOR_BLACK);
- init_pair(2, COLOR_GREEN, COLOR_BLACK);
- init_pair(3, COLOR_YELLOW, COLOR_BLACK);
- init_pair(4, COLOR_WHITE, COLOR_BLACK);
- init_pair(5, COLOR_GREEN, COLOR_BLACK);
- init_pair(6, COLOR_CYAN, COLOR_BLACK);
- init_pair(7, COLOR_YELLOW, COLOR_BLACK);
- init_pair(8, COLOR_RED, COLOR_BLACK);
- init_pair(9, COLOR_BLUE, COLOR_BLACK);
- return tv;
-}
-
-void tv_destroy(tview_t *tv)
-{
- delwin(tv->wgoto); delwin(tv->whelp);
- endwin();
-
- bam_lplbuf_destroy(tv->lplbuf);
- bam_maqcns_destroy(tv->bmc);
- bam_index_destroy(tv->idx);
- if (tv->fai) fai_destroy(tv->fai);
- free(tv->ref);
- bam_header_destroy(tv->header);
- bam_close(tv->fp);
- free(tv);
-}
-
-int tv_fetch_func(const bam1_t *b, void *data)
-{
- tview_t *tv = (tview_t*)data;
- if (tv->no_skip) {
- uint32_t *cigar = bam1_cigar(b); // this is cheating...
- int i;
- for (i = 0; i <b->core.n_cigar; ++i) {
- if ((cigar[i]&0xf) == BAM_CREF_SKIP)
- cigar[i] = cigar[i]>>4<<4 | BAM_CDEL;
- }
- }
- bam_lplbuf_push(b, tv->lplbuf);
- return 0;
-}
-
-int tv_draw_aln(tview_t *tv, int tid, int pos)
-{
- // reset
- clear();
- tv->curr_tid = tid; tv->left_pos = pos;
- tv->last_pos = tv->left_pos - 1;
- tv->ccol = 0;
- // print ref and consensus
- if (tv->fai) {
- char *str;
- if (tv->ref) free(tv->ref);
- str = (char*)calloc(strlen(tv->header->target_name[tv->curr_tid]) + 30, 1);
- sprintf(str, "%s:%d-%d", tv->header->target_name[tv->curr_tid], tv->left_pos + 1, tv->left_pos + tv->mcol);
- tv->ref = fai_fetch(tv->fai, str, &tv->l_ref);
- free(str);
- }
- // draw aln
- bam_lplbuf_reset(tv->lplbuf);
- bam_fetch(tv->fp, tv->idx, tv->curr_tid, tv->left_pos, tv->left_pos + tv->mcol, tv, tv_fetch_func);
- bam_lplbuf_push(0, tv->lplbuf);
-
- while (tv->ccol < tv->mcol) {
- int pos = tv->last_pos + 1;
- if (pos%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", pos+1);
- mvaddch(1, tv->ccol++, (tv->ref && pos < tv->l_ref)? tv->ref[pos - tv->left_pos] : 'N');
- ++tv->last_pos;
- }
- return 0;
-}
-
-static void tv_win_goto(tview_t *tv, int *tid, int *pos)
-{
- char str[256], *p;
- int i, l = 0;
- wborder(tv->wgoto, '|', '|', '-', '-', '+', '+', '+', '+');
- mvwprintw(tv->wgoto, 1, 2, "Goto: ");
- for (;;) {
- int c = wgetch(tv->wgoto);
- wrefresh(tv->wgoto);
- if (c == KEY_BACKSPACE || c == '\010' || c == '\177') {
- --l;
- } else if (c == KEY_ENTER || c == '\012' || c == '\015') {
- int _tid = -1, _beg, _end;
- if (str[0] == '=') {
- _beg = strtol(str+1, &p, 10);
- if (_beg > 0) {
- *pos = _beg;
- return;
- }
- } else {
- bam_parse_region(tv->header, str, &_tid, &_beg, &_end);
- if (_tid >= 0) {
- *tid = _tid; *pos = _beg;
- return;
- }
- }
- } else if (isgraph(c)) {
- if (l < TV_MAX_GOTO) str[l++] = c;
- } else if (c == '\027') l = 0;
- else if (c == '\033') return;
- str[l] = '\0';
- for (i = 0; i < TV_MAX_GOTO; ++i) mvwaddch(tv->wgoto, 1, 8 + i, ' ');
- mvwprintw(tv->wgoto, 1, 8, "%s", str);
- }
-}
-
-static void tv_win_help(tview_t *tv) {
- int r = 1;
- WINDOW *win = tv->whelp;
- wborder(win, '|', '|', '-', '-', '+', '+', '+', '+');
- mvwprintw(win, r++, 2, " -=- Help -=- ");
- r++;
- mvwprintw(win, r++, 2, "? This window");
- mvwprintw(win, r++, 2, "Arrows Small scroll movement");
- mvwprintw(win, r++, 2, "h,j,k,l Small scroll movement");
- mvwprintw(win, r++, 2, "H,J,K,L Large scroll movement");
- mvwprintw(win, r++, 2, "ctrl-H Scroll 1k left");
- mvwprintw(win, r++, 2, "ctrl-L Scroll 1k right");
- mvwprintw(win, r++, 2, "space Scroll one screen");
- mvwprintw(win, r++, 2, "backspace Scroll back one screen");
- mvwprintw(win, r++, 2, "g Go to specific location");
- mvwprintw(win, r++, 2, "m Color for mapping qual");
- mvwprintw(win, r++, 2, "n Color for nucleotide");
- mvwprintw(win, r++, 2, "b Color for base quality");
- mvwprintw(win, r++, 2, "c Color for cs color");
- mvwprintw(win, r++, 2, "z Color for cs qual");
- mvwprintw(win, r++, 2, ". Toggle on/off dot view");
- mvwprintw(win, r++, 2, "s Toggle on/off ref skip");
- mvwprintw(win, r++, 2, "r Toggle on/off rd name");
- mvwprintw(win, r++, 2, "N Turn on nt view");
- mvwprintw(win, r++, 2, "C Turn on cs view");
- mvwprintw(win, r++, 2, "i Toggle on/off ins");
- mvwprintw(win, r++, 2, "q Exit");
- r++;
- mvwprintw(win, r++, 2, "Underline: Secondary or orphan");
- mvwprintw(win, r++, 2, "Blue: 0-9 Green: 10-19");
- mvwprintw(win, r++, 2, "Yellow: 20-29 White: >=30");
- wrefresh(win);
- wgetch(win);
-}
-
-void tv_loop(tview_t *tv)
-{
- int tid, pos;
- tid = tv->curr_tid; pos = tv->left_pos;
- while (1) {
- int c = getch();
- switch (c) {
- case '?': tv_win_help(tv); break;
- case '\033':
- case 'q': goto end_loop;
- case '/':
- case 'g': tv_win_goto(tv, &tid, &pos); break;
- case 'm': tv->color_for = TV_COLOR_MAPQ; break;
- case 'b': tv->color_for = TV_COLOR_BASEQ; break;
- case 'n': tv->color_for = TV_COLOR_NUCL; break;
- case 'c': tv->color_for = TV_COLOR_COL; break;
- case 'z': tv->color_for = TV_COLOR_COLQ; break;
- case 's': tv->no_skip = !tv->no_skip; break;
- case 'r': tv->show_name = !tv->show_name; break;
- case KEY_LEFT:
- case 'h': --pos; break;
- case KEY_RIGHT:
- case 'l': ++pos; break;
- case KEY_SLEFT:
- case 'H': pos -= 20; break;
- case KEY_SRIGHT:
- case 'L': pos += 20; break;
- case '.': tv->is_dot = !tv->is_dot; break;
- case 'N': tv->base_for = TV_BASE_NUCL; break;
- case 'C': tv->base_for = TV_BASE_COLOR_SPACE; break;
- case 'i': tv->ins = !tv->ins; break;
- case '\010': pos -= 1000; break;
- case '\014': pos += 1000; break;
- case ' ': pos += tv->mcol; break;
- case KEY_UP:
- case 'j': --tv->row_shift; break;
- case KEY_DOWN:
- case 'k': ++tv->row_shift; break;
- case KEY_BACKSPACE:
- case '\177': pos -= tv->mcol; break;
- case KEY_RESIZE: getmaxyx(stdscr, tv->mrow, tv->mcol); break;
- default: continue;
- }
- if (pos < 0) pos = 0;
- if (tv->row_shift < 0) tv->row_shift = 0;
- tv_draw_aln(tv, tid, pos);
- }
-end_loop:
- return;
-}
-
-int bam_tview_main(int argc, char *argv[])
-{
- tview_t *tv;
- if (argc == 1) {
- fprintf(stderr, "Usage: bamtk tview <aln.bam> [ref.fasta]\n");
- return 1;
- }
- tv = tv_init(argv[1], (argc == 2)? 0 : argv[2]);
- tv_draw_aln(tv, 0, 0);
- tv_loop(tv);
- tv_destroy(tv);
- return 0;
-}
-#else // #ifdef _HAVE_CURSES
-#include <stdio.h>
-#warning "No curses library is available; tview is disabled."
-int bam_tview_main(int argc, char *argv[])
-{
- fprintf(stderr, "[bam_tview_main] The ncurses library is unavailable; tview is not compiled.\n");
- return 1;
-}
-#endif // #ifdef _HAVE_CURSES
--- /dev/null
+#include "pysam.h"
+
+#undef _HAVE_CURSES
+
+#if _CURSES_LIB == 0
+#elif _CURSES_LIB == 1
+#include <curses.h>
+#ifndef NCURSES_VERSION
+#warning "_CURSES_LIB=1 but NCURSES_VERSION not defined; tview is NOT compiled"
+#else
+#define _HAVE_CURSES
+#endif
+#elif _CURSES_LIB == 2
+#include <xcurses.h>
+#define _HAVE_CURSES
+#else
+#warning "_CURSES_LIB is not 0, 1 or 2; tview is NOT compiled"
+#endif
+
+#ifdef _HAVE_CURSES
+#include <ctype.h>
+#include <assert.h>
+#include <string.h>
+#include "bam.h"
+#include "faidx.h"
+#include "bam_maqcns.h"
+
+char bam_aux_getCEi(bam1_t *b, int i);
+char bam_aux_getCSi(bam1_t *b, int i);
+char bam_aux_getCQi(bam1_t *b, int i);
+
+#define TV_MIN_ALNROW 2
+#define TV_MAX_GOTO 40
+#define TV_LOW_MAPQ 10
+
+#define TV_COLOR_MAPQ 0
+#define TV_COLOR_BASEQ 1
+#define TV_COLOR_NUCL 2
+#define TV_COLOR_COL 3
+#define TV_COLOR_COLQ 4
+
+#define TV_BASE_NUCL 0
+#define TV_BASE_COLOR_SPACE 1
+
+typedef struct {
+ int mrow, mcol;
+ WINDOW *wgoto, *whelp;
+
+ bam_index_t *idx;
+ bam_lplbuf_t *lplbuf;
+ bam_header_t *header;
+ bamFile fp;
+ int curr_tid, left_pos;
+ faidx_t *fai;
+ bam_maqcns_t *bmc;
+
+ int ccol, last_pos, row_shift, base_for, color_for, is_dot, l_ref, ins, no_skip, show_name;
+ char *ref;
+} tview_t;
+
+int tv_pl_func(uint32_t tid, uint32_t pos, int n, const bam_pileup1_t *pl, void *data)
+{
+ tview_t *tv = (tview_t*)data;
+ int i, j, c, rb, attr, max_ins = 0;
+ uint32_t call = 0;
+ if (pos < tv->left_pos || tv->ccol > tv->mcol) return 0; // out of screen
+ // print referece
+ rb = (tv->ref && pos - tv->left_pos < tv->l_ref)? tv->ref[pos - tv->left_pos] : 'N';
+ for (i = tv->last_pos + 1; i < pos; ++i) {
+ if (i%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", i+1);
+ c = tv->ref? tv->ref[i - tv->left_pos] : 'N';
+ mvaddch(1, tv->ccol++, c);
+ }
+ if (pos%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", pos+1);
+ // print consensus
+ call = bam_maqcns_call(n, pl, tv->bmc);
+ attr = A_UNDERLINE;
+ c = ",ACMGRSVTWYHKDBN"[call>>28&0xf];
+ i = (call>>8&0xff)/10+1;
+ if (i > 4) i = 4;
+ attr |= COLOR_PAIR(i);
+ if (c == toupper(rb)) c = '.';
+ attron(attr);
+ mvaddch(2, tv->ccol, c);
+ attroff(attr);
+ if(tv->ins) {
+ // calculate maximum insert
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ if (p->indel > 0 && max_ins < p->indel) max_ins = p->indel;
+ }
+ }
+ // core loop
+ for (j = 0; j <= max_ins; ++j) {
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = pl + i;
+ int row = TV_MIN_ALNROW + p->level - tv->row_shift;
+ if (j == 0) {
+ if (!p->is_del) {
+ if (tv->base_for == TV_BASE_COLOR_SPACE &&
+ (c = bam_aux_getCSi(p->b, p->qpos))) {
+ c = bam_aux_getCSi(p->b, p->qpos);
+ // assume that if we found one color, we will be able to get the color error
+ if (tv->is_dot && '-' == bam_aux_getCEi(p->b, p->qpos)) c = bam1_strand(p->b)? ',' : '.';
+ } else {
+ if (tv->show_name) {
+ char *name = bam1_qname(p->b);
+ c = (p->qpos + 1 >= p->b->core.l_qname)? ' ' : name[p->qpos];
+ } else {
+ c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos)];
+ if (tv->is_dot && toupper(c) == toupper(rb)) c = bam1_strand(p->b)? ',' : '.';
+ }
+ }
+ } else c = p->is_refskip? (bam1_strand(p->b)? '<' : '>') : '*';
+ } else { // padding
+ if (j > p->indel) c = '*';
+ else { // insertion
+ if (tv->base_for == TV_BASE_NUCL) {
+ if (tv->show_name) {
+ char *name = bam1_qname(p->b);
+ c = (p->qpos + j + 1 >= p->b->core.l_qname)? ' ' : name[p->qpos + j];
+ } else {
+ c = bam_nt16_rev_table[bam1_seqi(bam1_seq(p->b), p->qpos + j)];
+ if (j == 0 && tv->is_dot && toupper(c) == toupper(rb)) c = bam1_strand(p->b)? ',' : '.';
+ }
+ } else {
+ c = bam_aux_getCSi(p->b, p->qpos + j);
+ if (tv->is_dot && '-' == bam_aux_getCEi(p->b, p->qpos + j)) c = bam1_strand(p->b)? ',' : '.';
+ }
+ }
+ }
+ if (row > TV_MIN_ALNROW && row < tv->mrow) {
+ int x;
+ attr = 0;
+ if (((p->b->core.flag&BAM_FPAIRED) && !(p->b->core.flag&BAM_FPROPER_PAIR))
+ || (p->b->core.flag & BAM_FSECONDARY)) attr |= A_UNDERLINE;
+ if (tv->color_for == TV_COLOR_BASEQ) {
+ x = bam1_qual(p->b)[p->qpos]/10 + 1;
+ if (x > 4) x = 4;
+ attr |= COLOR_PAIR(x);
+ } else if (tv->color_for == TV_COLOR_MAPQ) {
+ x = p->b->core.qual/10 + 1;
+ if (x > 4) x = 4;
+ attr |= COLOR_PAIR(x);
+ } else if (tv->color_for == TV_COLOR_NUCL) {
+ x = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos)] + 5;
+ attr |= COLOR_PAIR(x);
+ } else if(tv->color_for == TV_COLOR_COL) {
+ x = 0;
+ switch(bam_aux_getCSi(p->b, p->qpos)) {
+ case '0': x = 0; break;
+ case '1': x = 1; break;
+ case '2': x = 2; break;
+ case '3': x = 3; break;
+ case '4': x = 4; break;
+ default: x = bam_nt16_nt4_table[bam1_seqi(bam1_seq(p->b), p->qpos)]; break;
+ }
+ x+=5;
+ attr |= COLOR_PAIR(x);
+ } else if(tv->color_for == TV_COLOR_COLQ) {
+ x = bam_aux_getCQi(p->b, p->qpos);
+ if(0 == x) x = bam1_qual(p->b)[p->qpos];
+ x = x/10 + 1;
+ if (x > 4) x = 4;
+ attr |= COLOR_PAIR(x);
+ }
+ attron(attr);
+ mvaddch(row, tv->ccol, bam1_strand(p->b)? tolower(c) : toupper(c));
+ attroff(attr);
+ }
+ }
+ c = j? '*' : rb;
+ if (c == '*') {
+ attr = COLOR_PAIR(8);
+ attron(attr);
+ mvaddch(1, tv->ccol++, c);
+ attroff(attr);
+ } else mvaddch(1, tv->ccol++, c);
+ }
+ tv->last_pos = pos;
+ return 0;
+}
+
+tview_t *tv_init(const char *fn, const char *fn_fa)
+{
+ tview_t *tv = (tview_t*)calloc(1, sizeof(tview_t));
+ tv->is_dot = 1;
+ tv->fp = bam_open(fn, "r");
+ bgzf_set_cache_size(tv->fp, 8 * 1024 *1024);
+ assert(tv->fp);
+ tv->header = bam_header_read(tv->fp);
+ tv->idx = bam_index_load(fn);
+ if (tv->idx == 0) exit(1);
+ tv->lplbuf = bam_lplbuf_init(tv_pl_func, tv);
+ if (fn_fa) tv->fai = fai_load(fn_fa);
+ tv->bmc = bam_maqcns_init();
+ tv->ins = 1;
+ bam_maqcns_prepare(tv->bmc);
+
+ initscr();
+ keypad(stdscr, TRUE);
+ clear();
+ noecho();
+ cbreak();
+ tv->mrow = 24; tv->mcol = 80;
+ getmaxyx(stdscr, tv->mrow, tv->mcol);
+ tv->wgoto = newwin(3, TV_MAX_GOTO + 10, 10, 5);
+ tv->whelp = newwin(29, 40, 5, 5);
+ tv->color_for = TV_COLOR_MAPQ;
+ start_color();
+ init_pair(1, COLOR_BLUE, COLOR_BLACK);
+ init_pair(2, COLOR_GREEN, COLOR_BLACK);
+ init_pair(3, COLOR_YELLOW, COLOR_BLACK);
+ init_pair(4, COLOR_WHITE, COLOR_BLACK);
+ init_pair(5, COLOR_GREEN, COLOR_BLACK);
+ init_pair(6, COLOR_CYAN, COLOR_BLACK);
+ init_pair(7, COLOR_YELLOW, COLOR_BLACK);
+ init_pair(8, COLOR_RED, COLOR_BLACK);
+ init_pair(9, COLOR_BLUE, COLOR_BLACK);
+ return tv;
+}
+
+void tv_destroy(tview_t *tv)
+{
+ delwin(tv->wgoto); delwin(tv->whelp);
+ endwin();
+
+ bam_lplbuf_destroy(tv->lplbuf);
+ bam_maqcns_destroy(tv->bmc);
+ bam_index_destroy(tv->idx);
+ if (tv->fai) fai_destroy(tv->fai);
+ free(tv->ref);
+ bam_header_destroy(tv->header);
+ bam_close(tv->fp);
+ free(tv);
+}
+
+int tv_fetch_func(const bam1_t *b, void *data)
+{
+ tview_t *tv = (tview_t*)data;
+ if (tv->no_skip) {
+ uint32_t *cigar = bam1_cigar(b); // this is cheating...
+ int i;
+ for (i = 0; i <b->core.n_cigar; ++i) {
+ if ((cigar[i]&0xf) == BAM_CREF_SKIP)
+ cigar[i] = cigar[i]>>4<<4 | BAM_CDEL;
+ }
+ }
+ bam_lplbuf_push(b, tv->lplbuf);
+ return 0;
+}
+
+int tv_draw_aln(tview_t *tv, int tid, int pos)
+{
+ // reset
+ clear();
+ tv->curr_tid = tid; tv->left_pos = pos;
+ tv->last_pos = tv->left_pos - 1;
+ tv->ccol = 0;
+ // print ref and consensus
+ if (tv->fai) {
+ char *str;
+ if (tv->ref) free(tv->ref);
+ str = (char*)calloc(strlen(tv->header->target_name[tv->curr_tid]) + 30, 1);
+ sprintf(str, "%s:%d-%d", tv->header->target_name[tv->curr_tid], tv->left_pos + 1, tv->left_pos + tv->mcol);
+ tv->ref = fai_fetch(tv->fai, str, &tv->l_ref);
+ free(str);
+ }
+ // draw aln
+ bam_lplbuf_reset(tv->lplbuf);
+ bam_fetch(tv->fp, tv->idx, tv->curr_tid, tv->left_pos, tv->left_pos + tv->mcol, tv, tv_fetch_func);
+ bam_lplbuf_push(0, tv->lplbuf);
+
+ while (tv->ccol < tv->mcol) {
+ int pos = tv->last_pos + 1;
+ if (pos%10 == 0 && tv->mcol - tv->ccol >= 10) mvprintw(0, tv->ccol, "%-d", pos+1);
+ mvaddch(1, tv->ccol++, (tv->ref && pos < tv->l_ref)? tv->ref[pos - tv->left_pos] : 'N');
+ ++tv->last_pos;
+ }
+ return 0;
+}
+
+static void tv_win_goto(tview_t *tv, int *tid, int *pos)
+{
+ char str[256], *p;
+ int i, l = 0;
+ wborder(tv->wgoto, '|', '|', '-', '-', '+', '+', '+', '+');
+ mvwprintw(tv->wgoto, 1, 2, "Goto: ");
+ for (;;) {
+ int c = wgetch(tv->wgoto);
+ wrefresh(tv->wgoto);
+ if (c == KEY_BACKSPACE || c == '\010' || c == '\177') {
+ --l;
+ } else if (c == KEY_ENTER || c == '\012' || c == '\015') {
+ int _tid = -1, _beg, _end;
+ if (str[0] == '=') {
+ _beg = strtol(str+1, &p, 10) - 1;
+ if (_beg > 0) {
+ *pos = _beg;
+ return;
+ }
+ } else {
+ bam_parse_region(tv->header, str, &_tid, &_beg, &_end);
+ if (_tid >= 0) {
+ *tid = _tid; *pos = _beg;
+ return;
+ }
+ }
+ } else if (isgraph(c)) {
+ if (l < TV_MAX_GOTO) str[l++] = c;
+ } else if (c == '\027') l = 0;
+ else if (c == '\033') return;
+ str[l] = '\0';
+ for (i = 0; i < TV_MAX_GOTO; ++i) mvwaddch(tv->wgoto, 1, 8 + i, ' ');
+ mvwprintw(tv->wgoto, 1, 8, "%s", str);
+ }
+}
+
+static void tv_win_help(tview_t *tv) {
+ int r = 1;
+ WINDOW *win = tv->whelp;
+ wborder(win, '|', '|', '-', '-', '+', '+', '+', '+');
+ mvwprintw(win, r++, 2, " -=- Help -=- ");
+ r++;
+ mvwprintw(win, r++, 2, "? This window");
+ mvwprintw(win, r++, 2, "Arrows Small scroll movement");
+ mvwprintw(win, r++, 2, "h,j,k,l Small scroll movement");
+ mvwprintw(win, r++, 2, "H,J,K,L Large scroll movement");
+ mvwprintw(win, r++, 2, "ctrl-H Scroll 1k left");
+ mvwprintw(win, r++, 2, "ctrl-L Scroll 1k right");
+ mvwprintw(win, r++, 2, "space Scroll one screen");
+ mvwprintw(win, r++, 2, "backspace Scroll back one screen");
+ mvwprintw(win, r++, 2, "g Go to specific location");
+ mvwprintw(win, r++, 2, "m Color for mapping qual");
+ mvwprintw(win, r++, 2, "n Color for nucleotide");
+ mvwprintw(win, r++, 2, "b Color for base quality");
+ mvwprintw(win, r++, 2, "c Color for cs color");
+ mvwprintw(win, r++, 2, "z Color for cs qual");
+ mvwprintw(win, r++, 2, ". Toggle on/off dot view");
+ mvwprintw(win, r++, 2, "s Toggle on/off ref skip");
+ mvwprintw(win, r++, 2, "r Toggle on/off rd name");
+ mvwprintw(win, r++, 2, "N Turn on nt view");
+ mvwprintw(win, r++, 2, "C Turn on cs view");
+ mvwprintw(win, r++, 2, "i Toggle on/off ins");
+ mvwprintw(win, r++, 2, "q Exit");
+ r++;
+ mvwprintw(win, r++, 2, "Underline: Secondary or orphan");
+ mvwprintw(win, r++, 2, "Blue: 0-9 Green: 10-19");
+ mvwprintw(win, r++, 2, "Yellow: 20-29 White: >=30");
+ wrefresh(win);
+ wgetch(win);
+}
+
+void tv_loop(tview_t *tv)
+{
+ int tid, pos;
+ tid = tv->curr_tid; pos = tv->left_pos;
+ while (1) {
+ int c = getch();
+ switch (c) {
+ case '?': tv_win_help(tv); break;
+ case '\033':
+ case 'q': goto end_loop;
+ case '/':
+ case 'g': tv_win_goto(tv, &tid, &pos); break;
+ case 'm': tv->color_for = TV_COLOR_MAPQ; break;
+ case 'b': tv->color_for = TV_COLOR_BASEQ; break;
+ case 'n': tv->color_for = TV_COLOR_NUCL; break;
+ case 'c': tv->color_for = TV_COLOR_COL; break;
+ case 'z': tv->color_for = TV_COLOR_COLQ; break;
+ case 's': tv->no_skip = !tv->no_skip; break;
+ case 'r': tv->show_name = !tv->show_name; break;
+ case KEY_LEFT:
+ case 'h': --pos; break;
+ case KEY_RIGHT:
+ case 'l': ++pos; break;
+ case KEY_SLEFT:
+ case 'H': pos -= 20; break;
+ case KEY_SRIGHT:
+ case 'L': pos += 20; break;
+ case '.': tv->is_dot = !tv->is_dot; break;
+ case 'N': tv->base_for = TV_BASE_NUCL; break;
+ case 'C': tv->base_for = TV_BASE_COLOR_SPACE; break;
+ case 'i': tv->ins = !tv->ins; break;
+ case '\010': pos -= 1000; break;
+ case '\014': pos += 1000; break;
+ case ' ': pos += tv->mcol; break;
+ case KEY_UP:
+ case 'j': --tv->row_shift; break;
+ case KEY_DOWN:
+ case 'k': ++tv->row_shift; break;
+ case KEY_BACKSPACE:
+ case '\177': pos -= tv->mcol; break;
+ case KEY_RESIZE: getmaxyx(stdscr, tv->mrow, tv->mcol); break;
+ default: continue;
+ }
+ if (pos < 0) pos = 0;
+ if (tv->row_shift < 0) tv->row_shift = 0;
+ tv_draw_aln(tv, tid, pos);
+ }
+end_loop:
+ return;
+}
+
+int bam_tview_main(int argc, char *argv[])
+{
+ tview_t *tv;
+ if (argc == 1) {
+ fprintf(pysamerr, "Usage: bamtk tview <aln.bam> [ref.fasta]\n");
+ return 1;
+ }
+ tv = tv_init(argv[1], (argc == 2)? 0 : argv[2]);
+ tv_draw_aln(tv, 0, 0);
+ tv_loop(tv);
+ tv_destroy(tv);
+ return 0;
+}
+#else // #ifdef _HAVE_CURSES
+#include <stdio.h>
+#warning "No curses library is available; tview is disabled."
+int bam_tview_main(int argc, char *argv[])
+{
+ fprintf(pysamerr, "[bam_tview_main] The ncurses library is unavailable; tview is not compiled.\n");
+ return 1;
+}
+#endif // #ifdef _HAVE_CURSES
--- /dev/null
+#include "pysam.h"
+
+#include <string.h>
+#include <ctype.h>
+#include <stdio.h>
+#include "kstring.h"
+#include "bcf.h"
+
+bcf_t *bcf_open(const char *fn, const char *mode)
+{
+ bcf_t *b;
+ b = calloc(1, sizeof(bcf_t));
+ if (strchr(mode, 'w')) {
+ b->fp = strcmp(fn, "-")? bgzf_open(fn, mode) : bgzf_fdopen(fileno(stdout), mode);
+ } else {
+ b->fp = strcmp(fn, "-")? bgzf_open(fn, mode) : bgzf_fdopen(fileno(stdin), mode);
+ }
+#ifndef BCF_LITE
+ b->fp->owned_file = 1;
+#endif
+ return b;
+}
+
+int bcf_close(bcf_t *b)
+{
+ int ret;
+ if (b == 0) return 0;
+ ret = bgzf_close(b->fp);
+ free(b);
+ return ret;
+}
+
+int bcf_hdr_write(bcf_t *b, const bcf_hdr_t *h)
+{
+ if (b == 0 || h == 0) return -1;
+ bgzf_write(b->fp, "BCF\4", 4);
+ bgzf_write(b->fp, &h->l_nm, 4);
+ bgzf_write(b->fp, h->name, h->l_nm);
+ bgzf_write(b->fp, &h->l_smpl, 4);
+ bgzf_write(b->fp, h->sname, h->l_smpl);
+ bgzf_write(b->fp, &h->l_txt, 4);
+ bgzf_write(b->fp, h->txt, h->l_txt);
+ bgzf_flush(b->fp);
+ return 16 + h->l_nm + h->l_smpl + h->l_txt;
+}
+
+bcf_hdr_t *bcf_hdr_read(bcf_t *b)
+{
+ uint8_t magic[4];
+ bcf_hdr_t *h;
+ if (b == 0) return 0;
+ h = calloc(1, sizeof(bcf_hdr_t));
+ bgzf_read(b->fp, magic, 4);
+ bgzf_read(b->fp, &h->l_nm, 4);
+ h->name = malloc(h->l_nm);
+ bgzf_read(b->fp, h->name, h->l_nm);
+ bgzf_read(b->fp, &h->l_smpl, 4);
+ h->sname = malloc(h->l_smpl);
+ bgzf_read(b->fp, h->sname, h->l_smpl);
+ bgzf_read(b->fp, &h->l_txt, 4);
+ h->txt = malloc(h->l_txt);
+ bgzf_read(b->fp, h->txt, h->l_txt);
+ bcf_hdr_sync(h);
+ return h;
+}
+
+void bcf_hdr_destroy(bcf_hdr_t *h)
+{
+ if (h == 0) return;
+ free(h->name); free(h->sname); free(h->txt); free(h->ns); free(h->sns);
+ free(h);
+}
+
+static inline char **cnt_null(int l, char *str, int *_n)
+{
+ int n = 0;
+ char *p, **list;
+ *_n = 0;
+ if (l == 0 || str == 0) return 0;
+ for (p = str; p != str + l; ++p)
+ if (*p == 0) ++n;
+ *_n = n;
+ list = calloc(n, sizeof(void*));
+ list[0] = str;
+ for (p = str, n = 1; p < str + l - 1; ++p)
+ if (*p == 0) list[n++] = p + 1;
+ return list;
+}
+
+int bcf_hdr_sync(bcf_hdr_t *b)
+{
+ if (b == 0) return -1;
+ if (b->ns) free(b->ns);
+ if (b->sns) free(b->sns);
+ if (b->l_nm) b->ns = cnt_null(b->l_nm, b->name, &b->n_ref);
+ else b->ns = 0, b->n_ref = 0;
+ b->sns = cnt_null(b->l_smpl, b->sname, &b->n_smpl);
+ return 0;
+}
+
+int bcf_sync(bcf1_t *b)
+{
+ char *p, *tmp[5];
+ int i, n, n_smpl = b->n_smpl;
+ ks_tokaux_t aux;
+ // set ref, alt, flt, info, fmt
+ b->ref = b->alt = b->flt = b->info = b->fmt = 0;
+ for (p = b->str, n = 0; p < b->str + b->l_str; ++p) {
+ if (*p == 0 && p+1 != b->str + b->l_str) {
+ if (n == 5) {
+ ++n;
+ break;
+ } else tmp[n++] = p + 1;
+ }
+ }
+ if (n != 5) {
+ fprintf(pysamerr, "[%s] incorrect number of fields (%d != 5) at %d:%d\n", __func__, n, b->tid, b->pos);
+ return -1;
+ }
+ b->ref = tmp[0]; b->alt = tmp[1]; b->flt = tmp[2]; b->info = tmp[3]; b->fmt = tmp[4];
+ // set n_alleles
+ if (*b->alt == 0) b->n_alleles = 1;
+ else {
+ for (p = b->alt, n = 1; *p; ++p)
+ if (*p == ',') ++n;
+ b->n_alleles = n + 1;
+ }
+ // set n_gi and gi[i].fmt
+ for (p = b->fmt, n = 1; *p; ++p)
+ if (*p == ':') ++n;
+ if (n > b->m_gi) {
+ int old_m = b->m_gi;
+ b->m_gi = n;
+ kroundup32(b->m_gi);
+ b->gi = realloc(b->gi, b->m_gi * sizeof(bcf_ginfo_t));
+ memset(b->gi + old_m, 0, (b->m_gi - old_m) * sizeof(bcf_ginfo_t));
+ }
+ b->n_gi = n;
+ for (p = kstrtok(b->fmt, ":", &aux), n = 0; p; p = kstrtok(0, 0, &aux))
+ b->gi[n++].fmt = bcf_str2int(p, aux.p - p);
+ // set gi[i].len
+ for (i = 0; i < b->n_gi; ++i) {
+ if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ b->gi[i].len = b->n_alleles * (b->n_alleles + 1) / 2;
+ } else if (b->gi[i].fmt == bcf_str2int("DP", 2) || b->gi[i].fmt == bcf_str2int("HQ", 2)) {
+ b->gi[i].len = 2;
+ } else if (b->gi[i].fmt == bcf_str2int("GQ", 2) || b->gi[i].fmt == bcf_str2int("GT", 2)) {
+ b->gi[i].len = 1;
+ } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
+ b->gi[i].len = 4;
+ } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
+ b->gi[i].len = b->n_alleles * (b->n_alleles + 1) / 2 * 4;
+ }
+ b->gi[i].data = realloc(b->gi[i].data, n_smpl * b->gi[i].len);
+ }
+ return 0;
+}
+
+int bcf_write(bcf_t *bp, const bcf_hdr_t *h, const bcf1_t *b)
+{
+ int i, l = 0;
+ if (b == 0) return -1;
+ bgzf_write(bp->fp, &b->tid, 4);
+ bgzf_write(bp->fp, &b->pos, 4);
+ bgzf_write(bp->fp, &b->qual, 4);
+ bgzf_write(bp->fp, &b->l_str, 4);
+ bgzf_write(bp->fp, b->str, b->l_str);
+ l = 12 + b->l_str;
+ for (i = 0; i < b->n_gi; ++i) {
+ bgzf_write(bp->fp, b->gi[i].data, b->gi[i].len * h->n_smpl);
+ l += b->gi[i].len * h->n_smpl;
+ }
+ return l;
+}
+
+int bcf_read(bcf_t *bp, const bcf_hdr_t *h, bcf1_t *b)
+{
+ int i, l = 0;
+ if (b == 0) return -1;
+ if (bgzf_read(bp->fp, &b->tid, 4) == 0) return -1;
+ b->n_smpl = h->n_smpl;
+ bgzf_read(bp->fp, &b->pos, 4);
+ bgzf_read(bp->fp, &b->qual, 4);
+ bgzf_read(bp->fp, &b->l_str, 4);
+ if (b->l_str > b->m_str) {
+ b->m_str = b->l_str;
+ kroundup32(b->m_str);
+ b->str = realloc(b->str, b->m_str);
+ }
+ bgzf_read(bp->fp, b->str, b->l_str);
+ l = 12 + b->l_str;
+ if (bcf_sync(b) < 0) return -2;
+ for (i = 0; i < b->n_gi; ++i) {
+ bgzf_read(bp->fp, b->gi[i].data, b->gi[i].len * h->n_smpl);
+ l += b->gi[i].len * h->n_smpl;
+ }
+ return l;
+}
+
+int bcf_destroy(bcf1_t *b)
+{
+ int i;
+ if (b == 0) return -1;
+ free(b->str);
+ for (i = 0; i < b->m_gi; ++i)
+ free(b->gi[i].data);
+ free(b->gi);
+ free(b);
+ return 0;
+}
+
+static inline void fmt_str(const char *p, kstring_t *s)
+{
+ if (*p == 0) kputc('.', s);
+ else kputs(p, s);
+}
+
+void bcf_fmt_core(const bcf_hdr_t *h, bcf1_t *b, kstring_t *s)
+{
+ int i, j, x;
+ s->l = 0;
+ if (h->n_ref) kputs(h->ns[b->tid], s);
+ else kputw(b->tid, s);
+ kputc('\t', s);
+ kputw(b->pos + 1, s); kputc('\t', s);
+ fmt_str(b->str, s); kputc('\t', s);
+ fmt_str(b->ref, s); kputc('\t', s);
+ fmt_str(b->alt, s); kputc('\t', s);
+ ksprintf(s, "%.3g", b->qual); kputc('\t', s);
+ fmt_str(b->flt, s); kputc('\t', s);
+ fmt_str(b->info, s);
+ if (b->fmt[0]) {
+ kputc('\t', s);
+ fmt_str(b->fmt, s);
+ }
+ x = b->n_alleles * (b->n_alleles + 1) / 2;
+ if (b->n_gi == 0) return;
+ for (j = 0; j < h->n_smpl; ++j) {
+ kputc('\t', s);
+ for (i = 0; i < b->n_gi; ++i) {
+ if (i) kputc(':', s);
+ if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ uint8_t *d = (uint8_t*)b->gi[i].data + j * x;
+ int k;
+ for (k = 0; k < x; ++k) {
+ if (k > 0) kputc(',', s);
+ kputw(d[k], s);
+ }
+ } else if (b->gi[i].fmt == bcf_str2int("DP", 2)) {
+ kputw(((uint16_t*)b->gi[i].data)[j], s);
+ } else if (b->gi[i].fmt == bcf_str2int("GQ", 2)) {
+ kputw(((uint8_t*)b->gi[i].data)[j], s);
+ } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
+ kputw(((int32_t*)b->gi[i].data)[j], s);
+ } else if (b->gi[i].fmt == bcf_str2int("GT", 2)) {
+ int y = ((uint8_t*)b->gi[i].data)[j];
+ if (y>>7&1) {
+ kputsn("./.", 3, s);
+ } else {
+ kputc('0' + (y>>3&7), s);
+ kputc("/|"[y>>6&1], s);
+ kputc('0' + (y&7), s);
+ }
+ } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
+ float *d = (float*)b->gi[i].data + j * x;
+ int k;
+ //printf("- %lx\n", d);
+ for (k = 0; k < x; ++k) {
+ if (k > 0) kputc(',', s);
+ ksprintf(s, "%.2f", d[k]);
+ }
+ } else kputc('.', s); // custom fields
+ }
+ }
+}
+
+char *bcf_fmt(const bcf_hdr_t *h, bcf1_t *b)
+{
+ kstring_t s;
+ s.l = s.m = 0; s.s = 0;
+ bcf_fmt_core(h, b, &s);
+ return s.s;
+}
+
+int bcf_append_info(bcf1_t *b, const char *info, int l)
+{
+ int shift = b->fmt - b->str;
+ int l_fmt = b->l_str - shift;
+ char *ori = b->str;
+ if (b->l_str + l > b->m_str) { // enlarge if necessary
+ b->m_str = b->l_str + l;
+ kroundup32(b->m_str);
+ b->str = realloc(b->str, b->m_str);
+ }
+ memmove(b->str + shift + l, b->str + shift, l_fmt); // move the FORMAT field
+ memcpy(b->str + shift - 1, info, l); // append to the INFO field
+ b->str[shift + l - 1] = '\0';
+ b->fmt = b->str + shift + l;
+ b->l_str += l;
+ if (ori != b->str) bcf_sync(b); // synchronize when realloc changes the pointer
+ return 0;
+}
+
+int bcf_cpy(bcf1_t *r, const bcf1_t *b)
+{
+ char *t1 = r->str;
+ bcf_ginfo_t *t2 = r->gi;
+ int i, t3 = r->m_str, t4 = r->m_gi;
+ *r = *b;
+ r->str = t1; r->gi = t2; r->m_str = t3; r->m_gi = t4;
+ if (r->m_str < b->m_str) {
+ r->m_str = b->m_str;
+ r->str = realloc(r->str, r->m_str);
+ }
+ memcpy(r->str, b->str, r->m_str);
+ bcf_sync(r); // calling bcf_sync() is simple but inefficient
+ for (i = 0; i < r->n_gi; ++i)
+ memcpy(r->gi[i].data, b->gi[i].data, r->n_smpl * r->gi[i].len);
+ return 0;
+}
+
+int bcf_is_indel(const bcf1_t *b)
+{
+ char *p;
+ if (strlen(b->ref) > 1) return 1;
+ for (p = b->alt; *p; ++p)
+ if (*p != ',' && p[1] != ',' && p[1] != '\0')
+ return 1;
+ return 0;
+}
--- /dev/null
+/* The MIT License
+
+ Copyright (c) 2010 Broad Institute
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+/* Contact: Heng Li <lh3@live.co.uk> */
+
+#ifndef BCF_H
+#define BCF_H
+
+#include <stdint.h>
+#include <zlib.h>
+
+#ifndef BCF_LITE
+#include "bgzf.h"
+typedef BGZF *bcfFile;
+#else
+typedef gzFile bcfFile;
+#define bgzf_open(fn, mode) gzopen(fn, mode)
+#define bgzf_fdopen(fd, mode) gzdopen(fd, mode)
+#define bgzf_close(fp) gzclose(fp)
+#define bgzf_read(fp, buf, len) gzread(fp, buf, len)
+#define bgzf_write(fp, buf, len)
+#define bgzf_flush(fp)
+#endif
+
+/*
+ A member in the structs below is said to "primary" if its content
+ cannot be inferred from other members in any of structs below; a
+ member is said to be "derived" if its content can be derived from
+ other members. For example, bcf1_t::str is primary as this comes from
+ the input data, while bcf1_t::info is derived as it can always be
+ correctly set if we know bcf1_t::str. Derived members are for quick
+ access to the content and must be synchronized with the primary data.
+ */
+
+typedef struct {
+ uint32_t fmt; // format of the block, set by bcf_str2int().
+ int len; // length of data for each individual
+ void *data; // concatenated data
+ // derived info: fmt, len (<-bcf1_t::fmt)
+} bcf_ginfo_t;
+
+typedef struct {
+ int32_t tid, pos; // refID and 0-based position
+ int32_t l_str, m_str; // length and the allocated size of ->str
+ float qual; // SNP quality
+ char *str; // concatenated string of variable length strings in VCF (from col.2 to col.7)
+ char *ref, *alt, *flt, *info, *fmt; // they all point to ->str; no memory allocation
+ int n_gi, m_gi; // number and the allocated size of geno fields
+ bcf_ginfo_t *gi; // array of geno fields
+ int n_alleles, n_smpl; // number of alleles and samples
+ // derived info: ref, alt, flt, info, fmt (<-str), n_gi (<-fmt), n_alleles (<-alt), n_smpl (<-bcf_hdr_t::n_smpl)
+} bcf1_t;
+
+typedef struct {
+ int32_t n_ref, n_smpl; // number of reference sequences and samples
+ int32_t l_nm; // length of concatenated sequence names; 0 padded
+ int32_t l_smpl; // length of concatenated sample names; 0 padded
+ int32_t l_txt; // length of header text (lines started with ##)
+ char *name, *sname, *txt; // concatenated sequence names, sample names and header text
+ char **ns, **sns; // array of sequence and sample names; point to name and sname, respectively
+ // derived info: n_ref (<-name), n_smpl (<-sname), ns (<-name), sns (<-sname)
+} bcf_hdr_t;
+
+typedef struct {
+ int is_vcf; // if the file in operation is a VCF
+ void *v; // auxillary data structure for VCF
+ bcfFile fp; // file handler for BCF
+} bcf_t;
+
+struct __bcf_idx_t;
+typedef struct __bcf_idx_t bcf_idx_t;
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ // open a BCF file; for BCF file only
+ bcf_t *bcf_open(const char *fn, const char *mode);
+ // close file
+ int bcf_close(bcf_t *b);
+ // read one record from BCF; return -1 on end-of-file, and <-1 for errors
+ int bcf_read(bcf_t *bp, const bcf_hdr_t *h, bcf1_t *b);
+ // call this function if b->str is changed
+ int bcf_sync(bcf1_t *b);
+ // write a BCF record
+ int bcf_write(bcf_t *bp, const bcf_hdr_t *h, const bcf1_t *b);
+ // read the BCF header; BCF only
+ bcf_hdr_t *bcf_hdr_read(bcf_t *b);
+ // write the BCF header
+ int bcf_hdr_write(bcf_t *b, const bcf_hdr_t *h);
+ // set bcf_hdr_t::ns and bcf_hdr_t::sns
+ int bcf_hdr_sync(bcf_hdr_t *b);
+ // destroy the header
+ void bcf_hdr_destroy(bcf_hdr_t *h);
+ // destroy a record
+ int bcf_destroy(bcf1_t *b);
+ // BCF->VCF conversion
+ char *bcf_fmt(const bcf_hdr_t *h, bcf1_t *b);
+ // append more info
+ int bcf_append_info(bcf1_t *b, const char *info, int l);
+ // copy
+ int bcf_cpy(bcf1_t *r, const bcf1_t *b);
+
+ // open a VCF or BCF file if "b" is set in "mode"
+ bcf_t *vcf_open(const char *fn, const char *mode);
+ // close a VCF/BCF file
+ int vcf_close(bcf_t *bp);
+ // read the VCF/BCF header
+ bcf_hdr_t *vcf_hdr_read(bcf_t *bp);
+ // read the sequence dictionary from a separate file; required for VCF->BCF conversion
+ int vcf_dictread(bcf_t *bp, bcf_hdr_t *h, const char *fn);
+ // read a VCF/BCF record; return -1 on end-of-file and <-1 for errors
+ int vcf_read(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b);
+ // write the VCF header
+ int vcf_hdr_write(bcf_t *bp, const bcf_hdr_t *h);
+ // write a VCF record
+ int vcf_write(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b);
+
+ // keep the first n alleles and discard the rest
+ int bcf_shrink_alt(bcf1_t *b, int n);
+ // convert GL to PL
+ int bcf_gl2pl(bcf1_t *b);
+ // if the site is an indel
+ int bcf_is_indel(const bcf1_t *b);
+ bcf_hdr_t *bcf_hdr_subsam(const bcf_hdr_t *h0, int n, char *const* samples, int *list);
+ int bcf_subsam(int n_smpl, int *list, bcf1_t *b);
+ // move GT to the first FORMAT field
+ int bcf_fix_gt(bcf1_t *b);
+ // update PL generated by old samtools
+ int bcf_fix_pl(bcf1_t *b);
+
+ // string hash table
+ void *bcf_build_refhash(bcf_hdr_t *h);
+ void bcf_str2id_destroy(void *_hash);
+ void bcf_str2id_thorough_destroy(void *_hash);
+ int bcf_str2id_add(void *_hash, const char *str);
+ int bcf_str2id(void *_hash, const char *str);
+ void *bcf_str2id_init();
+
+ // indexing related functions
+ int bcf_idx_build(const char *fn);
+ uint64_t bcf_idx_query(const bcf_idx_t *idx, int tid, int beg);
+ int bcf_parse_region(void *str2id, const char *str, int *tid, int *begin, int *end);
+ bcf_idx_t *bcf_idx_load(const char *fn);
+ void bcf_idx_destroy(bcf_idx_t *idx);
+
+#ifdef __cplusplus
+}
+#endif
+
+static inline uint32_t bcf_str2int(const char *str, int l)
+{
+ int i;
+ uint32_t x = 0;
+ for (i = 0; i < l && i < 4; ++i) {
+ if (str[i] == 0) return x;
+ x = x<<8 | str[i];
+ }
+ return x;
+}
+
+#endif
--- /dev/null
+#include "pysam.h"
+
+#include <errno.h>
+#include <math.h>
+#include <string.h>
+#include <stdlib.h>
+#include "bcf.h"
+
+static int8_t nt4_table[256] = {
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4 /*'-'*/, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 0, 4, 1, 4, 4, 4, 2, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 3, 4, 4, 4, -1, 4, 4, 4, 4, 4, 4, 4,
+ 4, 0, 4, 1, 4, 4, 4, 2, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 3, 4, 4, 4, -1, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4
+};
+
+static int read_I16(bcf1_t *b, int anno[16])
+{
+ char *p;
+ int i;
+ if ((p = strstr(b->info, "I16=")) == 0) return -1;
+ p += 4;
+ for (i = 0; i < 16; ++i) {
+ anno[i] = strtol(p, &p, 10);
+ if (anno[i] == 0 && (errno == EINVAL || errno == ERANGE)) return -2;
+ ++p;
+ }
+ return 0;
+}
+
+int bcf_2qcall(bcf_hdr_t *h, bcf1_t *b)
+{
+ int a[4], k, g[10], l, map[4], k1, j, i, i0, anno[16], dp, mq, d_rest;
+ char *s;
+ if (b->ref[1] != 0 || b->n_alleles > 4) return -1; // ref is not a single base
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == bcf_str2int("PL", 2)) break;
+ if (i == b->n_gi) return -1; // no PL
+ if (read_I16(b, anno) != 0) return -1; // no I16; FIXME: can be improved
+ d_rest = dp = anno[0] + anno[1] + anno[2] + anno[3];
+ if (dp == 0) return -1; // depth is zero
+ mq = (int)(sqrt((double)(anno[9] + anno[11]) / dp) + .499);
+ i0 = i;
+ a[0] = nt4_table[(int)b->ref[0]];
+ if (a[0] > 3) return -1; // ref is not A/C/G/T
+ a[1] = a[2] = a[3] = -2; // -1 has a special meaning
+ if (b->alt[0] == 0) return -1; // no alternate allele
+ map[0] = map[1] = map[2] = map[3] = -2;
+ map[a[0]] = 0;
+ for (k = 0, s = b->alt, k1 = -1; k < 3 && *s; ++k, s += 2) {
+ if (s[1] != ',' && s[1] != 0) return -1; // ALT is not single base
+ a[k+1] = nt4_table[(int)*s];
+ if (a[k+1] >= 0) map[a[k+1]] = k+1;
+ else k1 = k+1;
+ if (s[1] == 0) break;
+ }
+ for (k = 0; k < 4; ++k)
+ if (map[k] < 0) map[k] = k1;
+ for (i = 0; i < h->n_smpl; ++i) {
+ int d;
+ uint8_t *p = b->gi[i0].data + i * b->gi[i0].len;
+ for (j = 0; j < b->gi[i0].len; ++j)
+ if (p[j]) break;
+ d = (int)((double)d_rest / (h->n_smpl - i) + .499);
+ if (d == 0) d = 1;
+ if (j == b->gi[i0].len) d = 0;
+ d_rest -= d;
+ for (k = j = 0; k < 4; ++k) {
+ for (l = k; l < 4; ++l) {
+ int t, x = map[k], y = map[l];
+ if (x > y) t = x, x = y, y = t; // swap
+ g[j++] = p[y * (y+1) / 2 + x];
+ }
+ }
+ printf("%s\t%d\t%c", h->ns[b->tid], b->pos+1, *b->ref);
+ printf("\t%d\t%d\t0", d, mq);
+ for (j = 0; j < 10; ++j)
+ printf("\t%d", g[j]);
+ printf("\t%s\n", h->sns[i]);
+ }
+ return 0;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <string.h>
+#include <math.h>
+#include "bcf.h"
+#include "kstring.h"
+#include "khash.h"
+KHASH_MAP_INIT_STR(str2id, int)
+
+void *bcf_build_refhash(bcf_hdr_t *h)
+{
+ khash_t(str2id) *hash;
+ int i, ret;
+ hash = kh_init(str2id);
+ for (i = 0; i < h->n_ref; ++i) {
+ khint_t k;
+ k = kh_put(str2id, hash, h->ns[i], &ret); // FIXME: check ret
+ kh_val(hash, k) = i;
+ }
+ return hash;
+}
+
+void *bcf_str2id_init()
+{
+ return kh_init(str2id);
+}
+
+void bcf_str2id_destroy(void *_hash)
+{
+ khash_t(str2id) *hash = (khash_t(str2id)*)_hash;
+ if (hash) kh_destroy(str2id, hash); // Note that strings are not freed.
+}
+
+void bcf_str2id_thorough_destroy(void *_hash)
+{
+ khash_t(str2id) *hash = (khash_t(str2id)*)_hash;
+ khint_t k;
+ if (hash == 0) return;
+ for (k = 0; k < kh_end(hash); ++k)
+ if (kh_exist(hash, k)) free((char*)kh_key(hash, k));
+ kh_destroy(str2id, hash);
+}
+
+int bcf_str2id(void *_hash, const char *str)
+{
+ khash_t(str2id) *hash = (khash_t(str2id)*)_hash;
+ khint_t k;
+ if (!hash) return -1;
+ k = kh_get(str2id, hash, str);
+ return k == kh_end(hash)? -1 : kh_val(hash, k);
+}
+
+int bcf_str2id_add(void *_hash, const char *str)
+{
+ khint_t k;
+ int ret;
+ khash_t(str2id) *hash = (khash_t(str2id)*)_hash;
+ if (!hash) return -1;
+ k = kh_put(str2id, hash, str, &ret);
+ if (ret == 0) return kh_val(hash, k);
+ kh_val(hash, k) = kh_size(hash) - 1;
+ return kh_val(hash, k);
+}
+
+int bcf_shrink_alt(bcf1_t *b, int n)
+{
+ char *p;
+ int i, j, k, n_smpl = b->n_smpl;
+ if (b->n_alleles <= n) return -1;
+ // update ALT
+ if (n > 1) {
+ for (p = b->alt, k = 1; *p; ++p)
+ if (*p == ',' && ++k == n) break;
+ *p = '\0';
+ } else p = b->alt, *p = '\0';
+ ++p;
+ memmove(p, b->flt, b->str + b->l_str - b->flt);
+ b->l_str -= b->flt - p;
+ // update PL
+ for (i = 0; i < b->n_gi; ++i) {
+ bcf_ginfo_t *g = b->gi + i;
+ if (g->fmt == bcf_str2int("PL", 2)) {
+ int l, x = b->n_alleles * (b->n_alleles + 1) / 2;
+ uint8_t *d = (uint8_t*)g->data;
+ g->len = n * (n + 1) / 2;
+ for (l = k = 0; l < n_smpl; ++l) {
+ uint8_t *dl = d + l * x;
+ for (j = 0; j < g->len; ++j) d[k++] = dl[j];
+ }
+ } // FIXME: to add GL
+ }
+ b->n_alleles = n;
+ bcf_sync(b);
+ return 0;
+}
+
+int bcf_gl2pl(bcf1_t *b)
+{
+ char *p;
+ int i, n_smpl = b->n_smpl;
+ bcf_ginfo_t *g;
+ float *d0;
+ uint8_t *d1;
+ if (strstr(b->fmt, "PL")) return -1;
+ if ((p = strstr(b->fmt, "GL")) == 0) return -1;
+ *p = 'P';
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == bcf_str2int("GL", 2))
+ break;
+ g = b->gi + i;
+ g->fmt = bcf_str2int("PL", 2);
+ g->len /= 4; // 4 == sizeof(float)
+ d0 = (float*)g->data; d1 = (uint8_t*)g->data;
+ for (i = 0; i < n_smpl * g->len; ++i) {
+ int x = (int)(-10. * d0[i] + .499);
+ if (x > 255) x = 255;
+ if (x < 0) x = 0;
+ d1[i] = x;
+ }
+ return 0;
+}
+/* FIXME: this function will fail given AB:GTX:GT. BCFtools never
+ * produces such FMT, but others may do. */
+int bcf_fix_gt(bcf1_t *b)
+{
+ char *s;
+ int i;
+ uint32_t tmp;
+ bcf_ginfo_t gt;
+ // check the presence of the GT FMT
+ if ((s = strstr(b->fmt, ":GT")) == 0) return 0; // no GT or GT is already the first
+ if (s[3] != '\0' && s[3] != ':') return 0; // :GTX in fact
+ tmp = bcf_str2int("GT", 2);
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == tmp) break;
+ if (i == b->n_gi) return 0; // no GT in b->gi; probably a bug...
+ gt = b->gi[i];
+ // move GT to the first
+ for (; i > 0; --i) b->gi[i] = b->gi[i-1];
+ b->gi[0] = gt;
+ memmove(b->fmt + 3, b->fmt, s + 1 - b->fmt);
+ b->fmt[0] = 'G'; b->fmt[1] = 'T'; b->fmt[2] = ':';
+ return 0;
+}
+
+int bcf_fix_pl(bcf1_t *b)
+{
+ int i;
+ uint32_t tmp;
+ uint8_t *PL, *swap;
+ bcf_ginfo_t *gi;
+ // pinpoint PL
+ tmp = bcf_str2int("PL", 2);
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == tmp) break;
+ if (i == b->n_gi) return 0;
+ // prepare
+ gi = b->gi + i;
+ PL = (uint8_t*)gi->data;
+ swap = alloca(gi->len);
+ // loop through individuals
+ for (i = 0; i < b->n_smpl; ++i) {
+ int k, l, x;
+ uint8_t *PLi = PL + i * gi->len;
+ memcpy(swap, PLi, gi->len);
+ for (k = x = 0; k < b->n_alleles; ++k)
+ for (l = k; l < b->n_alleles; ++l)
+ PLi[l*(l+1)/2 + k] = swap[x++];
+ }
+ return 0;
+}
+
+int bcf_smpl_covered(const bcf1_t *b)
+{
+ int i, j, n = 0;
+ uint32_t tmp;
+ bcf_ginfo_t *gi;
+ // pinpoint PL
+ tmp = bcf_str2int("PL", 2);
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == tmp) break;
+ if (i == b->n_gi) return 0;
+ // count how many samples having PL!=[0..0]
+ gi = b->gi + i;
+ for (i = 0; i < b->n_smpl; ++i) {
+ uint8_t *PLi = ((uint8_t*)gi->data) + i * gi->len;
+ for (j = 0; j < gi->len; ++j)
+ if (PLi[j]) break;
+ if (j < gi->len) ++n;
+ }
+ return n;
+}
+
+static void *locate_field(const bcf1_t *b, const char *fmt, int l)
+{
+ int i;
+ uint32_t tmp;
+ tmp = bcf_str2int(fmt, l);
+ for (i = 0; i < b->n_gi; ++i)
+ if (b->gi[i].fmt == tmp) break;
+ return i == b->n_gi? 0 : b->gi[i].data;
+}
+
+int bcf_anno_max(bcf1_t *b)
+{
+ int k, max_gq, max_sp, n_het;
+ kstring_t str;
+ uint8_t *gt, *gq;
+ int32_t *sp;
+ max_gq = max_sp = n_het = 0;
+ gt = locate_field(b, "GT", 2);
+ if (gt == 0) return -1;
+ gq = locate_field(b, "GQ", 2);
+ sp = locate_field(b, "SP", 2);
+ if (sp)
+ for (k = 0; k < b->n_smpl; ++k)
+ if (gt[k]&0x3f)
+ max_sp = max_sp > (int)sp[k]? max_sp : sp[k];
+ if (gq)
+ for (k = 0; k < b->n_smpl; ++k)
+ if (gt[k]&0x3f)
+ max_gq = max_gq > (int)gq[k]? max_gq : gq[k];
+ for (k = 0; k < b->n_smpl; ++k) {
+ int a1, a2;
+ a1 = gt[k]&7; a2 = gt[k]>>3&7;
+ if ((!a1 && a2) || (!a2 && a1)) { // a het
+ if (gq == 0) ++n_het;
+ else if (gq[k] >= 20) ++n_het;
+ }
+ }
+ if (n_het) max_sp -= (int)(4.343 * log(n_het) + .499);
+ if (max_sp < 0) max_sp = 0;
+ memset(&str, 0, sizeof(kstring_t));
+ if (*b->info) kputc(';', &str);
+ ksprintf(&str, "MXSP=%d;MXGQ=%d", max_sp, max_gq);
+ bcf_append_info(b, str.s, str.l);
+ free(str.s);
+ return 0;
+}
+
+// FIXME: only data are shuffled; the header is NOT
+int bcf_shuffle(bcf1_t *b, int seed)
+{
+ int i, j, *a;
+ if (seed > 0) srand48(seed);
+ a = malloc(b->n_smpl * sizeof(int));
+ for (i = 0; i < b->n_smpl; ++i) a[i] = i;
+ for (i = b->n_smpl; i > 1; --i) {
+ int tmp;
+ j = (int)(drand48() * i);
+ tmp = a[j]; a[j] = a[i-1]; a[i-1] = tmp;
+ }
+ for (j = 0; j < b->n_gi; ++j) {
+ bcf_ginfo_t *gi = b->gi + j;
+ uint8_t *swap, *data = (uint8_t*)gi->data;
+ swap = malloc(gi->len * b->n_smpl);
+ for (i = 0; i < b->n_smpl; ++i)
+ memcpy(swap + gi->len * a[i], data + gi->len * i, gi->len);
+ free(gi->data);
+ gi->data = swap;
+ }
+ free(a);
+ return 0;
+}
+
+bcf_hdr_t *bcf_hdr_subsam(const bcf_hdr_t *h0, int n, char *const* samples, int *list)
+{
+ int i, ret, j;
+ khint_t k;
+ bcf_hdr_t *h;
+ khash_t(str2id) *hash;
+ kstring_t s;
+ s.l = s.m = 0; s.s = 0;
+ hash = kh_init(str2id);
+ for (i = 0; i < h0->n_smpl; ++i) {
+ k = kh_put(str2id, hash, h0->sns[i], &ret);
+ kh_val(hash, k) = i;
+ }
+ for (i = j = 0; i < n; ++i) {
+ k = kh_get(str2id, hash, samples[i]);
+ if (k != kh_end(hash)) {
+ list[j++] = kh_val(hash, k);
+ kputs(samples[i], &s); kputc('\0', &s);
+ }
+ }
+ if (j < n) fprintf(pysamerr, "<%s> %d samples in the list but not in BCF.", __func__, n - j);
+ kh_destroy(str2id, hash);
+ h = calloc(1, sizeof(bcf_hdr_t));
+ *h = *h0;
+ h->ns = 0; h->sns = 0;
+ h->name = malloc(h->l_nm); memcpy(h->name, h0->name, h->l_nm);
+ h->txt = calloc(1, h->l_txt + 1); memcpy(h->txt, h0->txt, h->l_txt);
+ h->l_smpl = s.l; h->sname = s.s;
+ bcf_hdr_sync(h);
+ return h;
+}
+
+int bcf_subsam(int n_smpl, int *list, bcf1_t *b)
+{
+ int i, j;
+ for (j = 0; j < b->n_gi; ++j) {
+ bcf_ginfo_t *gi = b->gi + j;
+ uint8_t *swap;
+ swap = malloc(gi->len * b->n_smpl);
+ for (i = 0; i < n_smpl; ++i)
+ memcpy(swap + i * gi->len, (uint8_t*)gi->data + list[i] * gi->len, gi->len);
+ free(gi->data);
+ gi->data = swap;
+ }
+ b->n_smpl = n_smpl;
+ return 0;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <unistd.h>
+#include <stdlib.h>
+#include <math.h>
+#include <zlib.h>
+#include <errno.h>
+#include "bcf.h"
+#include "prob1.h"
+#include "kstring.h"
+#include "time.h"
+
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 16384)
+
+#define VC_NO_GENO 2
+#define VC_BCFOUT 4
+#define VC_CALL 8
+#define VC_VARONLY 16
+#define VC_VCFIN 32
+#define VC_UNCOMP 64
+#define VC_KEEPALT 256
+#define VC_ACGT_ONLY 512
+#define VC_QCALL 1024
+#define VC_CALL_GT 2048
+#define VC_ADJLD 4096
+#define VC_NO_INDEL 8192
+#define VC_ANNO_MAX 16384
+#define VC_FIX_PL 32768
+#define VC_EM 0x10000
+
+typedef struct {
+ int flag, prior_type, n1, n_sub, *sublist, n_perm;
+ char *prior_file, **subsam, *fn_dict;
+ uint8_t *ploidy;
+ double theta, pref, indel_frac, min_perm_p, min_smpl_frac, min_lrt;
+ void *bed;
+} viewconf_t;
+
+void *bed_read(const char *fn);
+void bed_destroy(void *_h);
+int bed_overlap(const void *_h, const char *chr, int beg, int end);
+
+typedef struct {
+ double p[4];
+ int mq, depth, is_tested, d[4];
+} anno16_t;
+
+static double ttest(int n1, int n2, int a[4])
+{
+ extern double kf_betai(double a, double b, double x);
+ double t, v, u1, u2;
+ if (n1 == 0 || n2 == 0 || n1 + n2 < 3) return 1.0;
+ u1 = (double)a[0] / n1; u2 = (double)a[2] / n2;
+ if (u1 <= u2) return 1.;
+ t = (u1 - u2) / sqrt(((a[1] - n1 * u1 * u1) + (a[3] - n2 * u2 * u2)) / (n1 + n2 - 2) * (1./n1 + 1./n2));
+ v = n1 + n2 - 2;
+// printf("%d,%d,%d,%d,%lf,%lf,%lf\n", a[0], a[1], a[2], a[3], t, u1, u2);
+ return t < 0.? 1. : .5 * kf_betai(.5*v, .5, v/(v+t*t));
+}
+
+static int test16_core(int anno[16], anno16_t *a)
+{
+ extern double kt_fisher_exact(int n11, int n12, int n21, int n22, double *_left, double *_right, double *two);
+ double left, right;
+ int i;
+ a->p[0] = a->p[1] = a->p[2] = a->p[3] = 1.;
+ memcpy(a->d, anno, 4 * sizeof(int));
+ a->depth = anno[0] + anno[1] + anno[2] + anno[3];
+ a->is_tested = (anno[0] + anno[1] > 0 && anno[2] + anno[3] > 0);
+ if (a->depth == 0) return -1;
+ a->mq = (int)(sqrt((anno[9] + anno[11]) / a->depth) + .499);
+ kt_fisher_exact(anno[0], anno[1], anno[2], anno[3], &left, &right, &a->p[0]);
+ for (i = 1; i < 4; ++i)
+ a->p[i] = ttest(anno[0] + anno[1], anno[2] + anno[3], anno+4*i);
+ return 0;
+}
+
+static int test16(bcf1_t *b, anno16_t *a)
+{
+ char *p;
+ int i, anno[16];
+ a->p[0] = a->p[1] = a->p[2] = a->p[3] = 1.;
+ a->d[0] = a->d[1] = a->d[2] = a->d[3] = 0.;
+ a->mq = a->depth = a->is_tested = 0;
+ if ((p = strstr(b->info, "I16=")) == 0) return -1;
+ p += 4;
+ for (i = 0; i < 16; ++i) {
+ errno = 0; anno[i] = strtol(p, &p, 10);
+ if (anno[i] == 0 && (errno == EINVAL || errno == ERANGE)) return -2;
+ ++p;
+ }
+ return test16_core(anno, a);
+}
+
+static void rm_info(bcf1_t *b, const char *key)
+{
+ char *p, *q;
+ if ((p = strstr(b->info, key)) == 0) return;
+ for (q = p; *q && *q != ';'; ++q);
+ if (p > b->info && *(p-1) == ';') --p;
+ memmove(p, q, b->l_str - (q - b->str));
+ b->l_str -= q - p;
+ bcf_sync(b);
+}
+
+static int update_bcf1(bcf1_t *b, const bcf_p1aux_t *pa, const bcf_p1rst_t *pr, double pref, int flag, double em[9])
+{
+ kstring_t s;
+ int has_I16, is_var;
+ double fq, r;
+ anno16_t a;
+
+ has_I16 = test16(b, &a) >= 0? 1 : 0;
+ rm_info(b, "I16="); // FIXME: probably this function has a bug. If I move it below, I16 will not be removed!
+
+ memset(&s, 0, sizeof(kstring_t));
+ kputc('\0', &s); kputs(b->ref, &s); kputc('\0', &s);
+ kputs(b->alt, &s); kputc('\0', &s); kputc('\0', &s);
+ kputs(b->info, &s);
+ if (b->info[0]) kputc(';', &s);
+ { // print EM
+ if (em[0] >= 0) ksprintf(&s, "AF1=%.4g", 1 - em[0]);
+ if (em[4] >= 0 && em[4] <= 0.05) ksprintf(&s, ";G3=%.4g,%.4g,%.4g;HWE=%.3g", em[3], em[2], em[1], em[4]);
+ if (em[5] >= 0 && em[6] >= 0) ksprintf(&s, ";AF2=%.4g,%.4g", 1 - em[5], 1 - em[6]);
+ if (em[7] >= 0) ksprintf(&s, ";LRT=%.3g", em[7]);
+ }
+ if (pr == 0) { // if pr is unset, return
+ kputc('\0', &s); kputs(b->fmt, &s); kputc('\0', &s);
+ free(b->str);
+ b->m_str = s.m; b->l_str = s.l; b->str = s.s;
+ bcf_sync(b);
+ return 1;
+ }
+
+ is_var = (pr->p_ref < pref);
+ r = is_var? pr->p_ref : pr->p_var;
+
+ ksprintf(&s, ";CI95=%.4g,%.4g", pr->cil, pr->cih); // FIXME: when EM is not used, ";" should be omitted!
+ if (has_I16) ksprintf(&s, ";DP4=%d,%d,%d,%d;MQ=%d", a.d[0], a.d[1], a.d[2], a.d[3], a.mq);
+ fq = pr->p_ref_folded < 0.5? -4.343 * log(pr->p_ref_folded) : 4.343 * log(pr->p_var_folded);
+ if (fq < -999) fq = -999;
+ if (fq > 999) fq = 999;
+ ksprintf(&s, ";FQ=%.3g", fq);
+ if (pr->cmp[0] >= 0.) { // two sample groups
+ int i, q[3];
+ for (i = 1; i < 3; ++i) {
+ double x = pr->cmp[i] + pr->cmp[0]/2.;
+ q[i] = x == 0? 255 : (int)(-4.343 * log(x) + .499);
+ if (q[i] > 255) q[i] = 255;
+ }
+ if (pr->perm_rank >= 0) ksprintf(&s, ";PR=%d", pr->perm_rank);
+ ksprintf(&s, ";PCHI2=%.3g;PC2=%d,%d", q[1], q[2], pr->p_chi2);
+ }
+ if (has_I16 && a.is_tested) ksprintf(&s, ";PV4=%.2g,%.2g,%.2g,%.2g", a.p[0], a.p[1], a.p[2], a.p[3]);
+ kputc('\0', &s);
+ kputs(b->fmt, &s); kputc('\0', &s);
+ free(b->str);
+ b->m_str = s.m; b->l_str = s.l; b->str = s.s;
+ b->qual = r < 1e-100? 999 : -4.343 * log(r);
+ if (b->qual > 999) b->qual = 999;
+ bcf_sync(b);
+ if (!is_var) bcf_shrink_alt(b, 1);
+ else if (!(flag&VC_KEEPALT))
+ bcf_shrink_alt(b, pr->rank0 < 2? 2 : pr->rank0+1);
+ if (is_var && (flag&VC_CALL_GT)) { // call individual genotype
+ int i, x, old_n_gi = b->n_gi;
+ s.m = b->m_str; s.l = b->l_str - 1; s.s = b->str;
+ kputs(":GT:GQ", &s); kputc('\0', &s);
+ b->m_str = s.m; b->l_str = s.l; b->str = s.s;
+ bcf_sync(b);
+ for (i = 0; i < b->n_smpl; ++i) {
+ x = bcf_p1_call_gt(pa, pr->f_exp, i);
+ ((uint8_t*)b->gi[old_n_gi].data)[i] = (x&3) == 0? 1<<3|1 : (x&3) == 1? 1 : 0;
+ ((uint8_t*)b->gi[old_n_gi+1].data)[i] = x>>2;
+ }
+ }
+ return is_var;
+}
+
+static char **read_samples(const char *fn, int *_n)
+{
+ gzFile fp;
+ kstream_t *ks;
+ kstring_t s;
+ int dret, n = 0, max = 0;
+ char **sam = 0;
+ *_n = 0;
+ s.l = s.m = 0; s.s = 0;
+ fp = gzopen(fn, "r");
+ if (fp == 0) return 0; // fail to open file
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, 0, &s, &dret) >= 0) {
+ int l;
+ if (max == n) {
+ max = max? max<<1 : 4;
+ sam = realloc(sam, sizeof(void*)*max);
+ }
+ l = s.l;
+ sam[n] = malloc(s.l + 2);
+ strcpy(sam[n], s.s);
+ sam[n][l+1] = 2; // by default, diploid
+ if (dret != '\n') {
+ if (ks_getuntil(ks, 0, &s, &dret) >= 0) { // read ploidy, 1 or 2
+ int x = (int)s.s[0] - '0';
+ if (x == 1 || x == 2) sam[n][l+1] = x;
+ else fprintf(pysamerr, "(%s) ploidy can only be 1 or 2; assume diploid\n", __func__);
+ }
+ if (dret != '\n') ks_getuntil(ks, '\n', &s, &dret);
+ }
+ ++n;
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(s.s);
+ *_n = n;
+ return sam;
+}
+
+static void write_header(bcf_hdr_t *h)
+{
+ kstring_t str;
+ str.l = h->l_txt? h->l_txt - 1 : 0;
+ str.m = str.l + 1; str.s = h->txt;
+ if (!strstr(str.s, "##INFO=<ID=DP,"))
+ kputs("##INFO=<ID=DP,Number=1,Type=Integer,Description=\"Raw read depth\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=DP4,"))
+ kputs("##INFO=<ID=DP4,Number=4,Type=Integer,Description=\"# high-quality ref-forward bases, ref-reverse, alt-forward and alt-reverse bases\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=MQ,"))
+ kputs("##INFO=<ID=MQ,Number=1,Type=Integer,Description=\"Root-mean-square mapping quality of covering reads\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=FQ,"))
+ kputs("##INFO=<ID=FQ,Number=1,Type=Float,Description=\"Phred probability of all samples being the same\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=AF1,"))
+ kputs("##INFO=<ID=AF1,Number=1,Type=Float,Description=\"Max-likelihood estimate of the site allele frequency of the first ALT allele\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=G3,"))
+ kputs("##INFO=<ID=G3,Number=3,Type=Float,Description=\"ML estimate of genotype frequencies\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=HWE,"))
+ kputs("##INFO=<ID=HWE,Number=1,Type=Float,Description=\"Chi^2 based HWE test P-value based on G3\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=CI95,"))
+ kputs("##INFO=<ID=CI95,Number=2,Type=Float,Description=\"Equal-tail Bayesian credible interval of the site allele frequency at the 95% level\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=PV4,"))
+ kputs("##INFO=<ID=PV4,Number=4,Type=Float,Description=\"P-values for strand bias, baseQ bias, mapQ bias and tail distance bias\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=INDEL,"))
+ kputs("##INFO=<ID=INDEL,Number=0,Type=Flag,Description=\"Indicates that the variant is an INDEL.\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=PC2,"))
+ kputs("##INFO=<ID=PC2,Number=2,Type=Integer,Description=\"Phred probability of the nonRef allele frequency in group1 samples being larger (,smaller) than in group2.\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=PCHI2,"))
+ kputs("##INFO=<ID=PCHI2,Number=1,Type=Float,Description=\"Posterior weighted chi^2 P-value for testing the association between group1 and group2 samples.\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=QCHI2,"))
+ kputs("##INFO=<ID=QCHI2,Number=1,Type=Integer,Description=\"Phred scaled PCHI2.\">\n", &str);
+ if (!strstr(str.s, "##INFO=<ID=RP,"))
+ kputs("##INFO=<ID=PR,Number=1,Type=Integer,Description=\"# permutations yielding a smaller PCHI2.\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=GT,"))
+ kputs("##FORMAT=<ID=GT,Number=1,Type=String,Description=\"Genotype\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=GQ,"))
+ kputs("##FORMAT=<ID=GQ,Number=1,Type=Integer,Description=\"Genotype Quality\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=GL,"))
+ kputs("##FORMAT=<ID=GL,Number=3,Type=Float,Description=\"Likelihoods for RR,RA,AA genotypes (R=ref,A=alt)\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=DP,"))
+ kputs("##FORMAT=<ID=DP,Number=1,Type=Integer,Description=\"# high-quality bases\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=SP,"))
+ kputs("##FORMAT=<ID=SP,Number=1,Type=Integer,Description=\"Phred-scaled strand bias P-value\">\n", &str);
+ if (!strstr(str.s, "##FORMAT=<ID=PL,"))
+ kputs("##FORMAT=<ID=PL,Number=-1,Type=Integer,Description=\"List of Phred-scaled genotype likelihoods, number of values is (#ALT+1)*(#ALT+2)/2\">\n", &str);
+ h->l_txt = str.l + 1; h->txt = str.s;
+}
+
+double bcf_pair_freq(const bcf1_t *b0, const bcf1_t *b1, double f[4]);
+
+int bcfview(int argc, char *argv[])
+{
+ extern int bcf_2qcall(bcf_hdr_t *h, bcf1_t *b);
+ extern void bcf_p1_indel_prior(bcf_p1aux_t *ma, double x);
+ extern int bcf_fix_gt(bcf1_t *b);
+ extern int bcf_anno_max(bcf1_t *b);
+ extern int bcf_shuffle(bcf1_t *b, int seed);
+ bcf_t *bp, *bout = 0;
+ bcf1_t *b, *blast;
+ int c, *seeds = 0;
+ uint64_t n_processed = 0;
+ viewconf_t vc;
+ bcf_p1aux_t *p1 = 0;
+ bcf_hdr_t *hin, *hout;
+ int tid, begin, end;
+ char moder[4], modew[4];
+
+ tid = begin = end = -1;
+ memset(&vc, 0, sizeof(viewconf_t));
+ vc.prior_type = vc.n1 = -1; vc.theta = 1e-3; vc.pref = 0.5; vc.indel_frac = -1.; vc.n_perm = 0; vc.min_perm_p = 0.01; vc.min_smpl_frac = 0; vc.min_lrt = 1;
+ while ((c = getopt(argc, argv, "FN1:l:cC:eHAGvbSuP:t:p:QgLi:IMs:D:U:X:d:")) >= 0) {
+ switch (c) {
+ case '1': vc.n1 = atoi(optarg); break;
+ case 'l': vc.bed = bed_read(optarg); break;
+ case 'D': vc.fn_dict = strdup(optarg); break;
+ case 'F': vc.flag |= VC_FIX_PL; break;
+ case 'N': vc.flag |= VC_ACGT_ONLY; break;
+ case 'G': vc.flag |= VC_NO_GENO; break;
+ case 'A': vc.flag |= VC_KEEPALT; break;
+ case 'b': vc.flag |= VC_BCFOUT; break;
+ case 'S': vc.flag |= VC_VCFIN; break;
+ case 'c': vc.flag |= VC_CALL; break;
+ case 'e': vc.flag |= VC_EM; break;
+ case 'v': vc.flag |= VC_VARONLY | VC_CALL; break;
+ case 'u': vc.flag |= VC_UNCOMP | VC_BCFOUT; break;
+ case 'g': vc.flag |= VC_CALL_GT | VC_CALL; break;
+ case 'I': vc.flag |= VC_NO_INDEL; break;
+ case 'M': vc.flag |= VC_ANNO_MAX; break;
+ case 't': vc.theta = atof(optarg); break;
+ case 'p': vc.pref = atof(optarg); break;
+ case 'i': vc.indel_frac = atof(optarg); break;
+ case 'Q': vc.flag |= VC_QCALL; break;
+ case 'L': vc.flag |= VC_ADJLD; break;
+ case 'U': vc.n_perm = atoi(optarg); break;
+ case 'C': vc.min_lrt = atof(optarg); break;
+ case 'X': vc.min_perm_p = atof(optarg); break;
+ case 'd': vc.min_smpl_frac = atof(optarg); break;
+ case 's': vc.subsam = read_samples(optarg, &vc.n_sub);
+ vc.ploidy = calloc(vc.n_sub + 1, 1);
+ for (tid = 0; tid < vc.n_sub; ++tid) vc.ploidy[tid] = vc.subsam[tid][strlen(vc.subsam[tid]) + 1];
+ tid = -1;
+ break;
+ case 'P':
+ if (strcmp(optarg, "full") == 0) vc.prior_type = MC_PTYPE_FULL;
+ else if (strcmp(optarg, "cond2") == 0) vc.prior_type = MC_PTYPE_COND2;
+ else if (strcmp(optarg, "flat") == 0) vc.prior_type = MC_PTYPE_FLAT;
+ else vc.prior_file = strdup(optarg);
+ break;
+ }
+ }
+ if (argc == optind) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: bcftools view [options] <in.bcf> [reg]\n\n");
+ fprintf(pysamerr, "Input/output options:\n\n");
+ fprintf(pysamerr, " -A keep all possible alternate alleles at variant sites\n");
+ fprintf(pysamerr, " -b output BCF instead of VCF\n");
+ fprintf(pysamerr, " -D FILE sequence dictionary for VCF->BCF conversion [null]\n");
+ fprintf(pysamerr, " -F PL generated by r921 or before (which generate old ordering)\n");
+ fprintf(pysamerr, " -G suppress all individual genotype information\n");
+ fprintf(pysamerr, " -l FILE list of sites (chr pos) or regions (BED) to output [all sites]\n");
+ fprintf(pysamerr, " -L calculate LD for adjacent sites\n");
+ fprintf(pysamerr, " -N skip sites where REF is not A/C/G/T\n");
+ fprintf(pysamerr, " -Q output the QCALL likelihood format\n");
+ fprintf(pysamerr, " -s FILE list of samples to use [all samples]\n");
+ fprintf(pysamerr, " -S input is VCF\n");
+ fprintf(pysamerr, " -u uncompressed BCF output (force -b)\n");
+ fprintf(pysamerr, "\nConsensus/variant calling options:\n\n");
+ fprintf(pysamerr, " -c SNP calling (force -e)\n");
+ fprintf(pysamerr, " -d FLOAT skip loci where less than FLOAT fraction of samples covered [0]\n");
+ fprintf(pysamerr, " -e likelihood based analyses\n");
+ fprintf(pysamerr, " -g call genotypes at variant sites (force -c)\n");
+ fprintf(pysamerr, " -i FLOAT indel-to-substitution ratio [%.4g]\n", vc.indel_frac);
+ fprintf(pysamerr, " -I skip indels\n");
+ fprintf(pysamerr, " -p FLOAT variant if P(ref|D)<FLOAT [%.3g]\n", vc.pref);
+ fprintf(pysamerr, " -P STR type of prior: full, cond2, flat [full]\n");
+ fprintf(pysamerr, " -t FLOAT scaled substitution mutation rate [%.4g]\n", vc.theta);
+ fprintf(pysamerr, " -v output potential variant sites only (force -c)\n");
+ fprintf(pysamerr, "\nContrast calling and association test options:\n\n");
+ fprintf(pysamerr, " -1 INT number of group-1 samples [0]\n");
+ fprintf(pysamerr, " -C FLOAT posterior constrast for LRT<FLOAT and P(ref|D)<0.5 [%g]\n", vc.min_lrt);
+ fprintf(pysamerr, " -U INT number of permutations for association testing (effective with -1) [0]\n");
+ fprintf(pysamerr, " -X FLOAT only perform permutations for P(chi^2)<FLOAT [%g]\n", vc.min_perm_p);
+ fprintf(pysamerr, "\n");
+ return 1;
+ }
+
+ if (vc.flag & VC_CALL) vc.flag |= VC_EM;
+ if ((vc.flag & VC_VCFIN) && (vc.flag & VC_BCFOUT) && vc.fn_dict == 0) {
+ fprintf(pysamerr, "[%s] For VCF->BCF conversion please specify the sequence dictionary with -D\n", __func__);
+ return 1;
+ }
+ if (vc.n1 <= 0) vc.n_perm = 0; // TODO: give a warning here!
+ if (vc.n_perm > 0) {
+ seeds = malloc(vc.n_perm * sizeof(int));
+ srand48(time(0));
+ for (c = 0; c < vc.n_perm; ++c) seeds[c] = lrand48();
+ }
+ b = calloc(1, sizeof(bcf1_t));
+ blast = calloc(1, sizeof(bcf1_t));
+ strcpy(moder, "r");
+ if (!(vc.flag & VC_VCFIN)) strcat(moder, "b");
+ strcpy(modew, "w");
+ if (vc.flag & VC_BCFOUT) strcat(modew, "b");
+ if (vc.flag & VC_UNCOMP) strcat(modew, "u");
+ bp = vcf_open(argv[optind], moder);
+ hin = hout = vcf_hdr_read(bp);
+ if (vc.fn_dict && (vc.flag & VC_VCFIN))
+ vcf_dictread(bp, hin, vc.fn_dict);
+ bout = vcf_open("-", modew);
+ if (!(vc.flag & VC_QCALL)) {
+ if (vc.n_sub) {
+ vc.sublist = calloc(vc.n_sub, sizeof(int));
+ hout = bcf_hdr_subsam(hin, vc.n_sub, vc.subsam, vc.sublist);
+ }
+ if (vc.flag & VC_CALL) write_header(hout);
+ vcf_hdr_write(bout, hout);
+ }
+ if (vc.flag & VC_CALL) {
+ p1 = bcf_p1_init(hout->n_smpl, vc.ploidy);
+ if (vc.prior_file) {
+ if (bcf_p1_read_prior(p1, vc.prior_file) < 0) {
+ fprintf(pysamerr, "[%s] fail to read the prior AFS.\n", __func__);
+ return 1;
+ }
+ } else bcf_p1_init_prior(p1, vc.prior_type, vc.theta);
+ if (vc.n1 > 0 && vc.min_lrt > 0.) { // set n1
+ bcf_p1_set_n1(p1, vc.n1);
+ bcf_p1_init_subprior(p1, vc.prior_type, vc.theta);
+ }
+ if (vc.indel_frac > 0.) bcf_p1_indel_prior(p1, vc.indel_frac); // otherwise use the default indel_frac
+ }
+ if (optind + 1 < argc && !(vc.flag&VC_VCFIN)) {
+ void *str2id = bcf_build_refhash(hout);
+ if (bcf_parse_region(str2id, argv[optind+1], &tid, &begin, &end) >= 0) {
+ bcf_idx_t *idx;
+ idx = bcf_idx_load(argv[optind]);
+ if (idx) {
+ uint64_t off;
+ off = bcf_idx_query(idx, tid, begin);
+ if (off == 0) {
+ fprintf(pysamerr, "[%s] no records in the query region.\n", __func__);
+ return 1; // FIXME: a lot of memory leaks...
+ }
+ bgzf_seek(bp->fp, off, SEEK_SET);
+ bcf_idx_destroy(idx);
+ }
+ }
+ }
+ while (vcf_read(bp, hin, b) > 0) {
+ int is_indel;
+ double em[9];
+ if ((vc.flag & VC_VARONLY) && strcmp(b->alt, "X") == 0) continue;
+ if ((vc.flag & VC_VARONLY) && vc.min_smpl_frac > 0.) {
+ extern int bcf_smpl_covered(const bcf1_t *b);
+ int n = bcf_smpl_covered(b);
+ if ((double)n / b->n_smpl < vc.min_smpl_frac) continue;
+ }
+ if (vc.n_sub) bcf_subsam(vc.n_sub, vc.sublist, b);
+ if (vc.flag & VC_FIX_PL) bcf_fix_pl(b);
+ is_indel = bcf_is_indel(b);
+ if ((vc.flag & VC_NO_INDEL) && is_indel) continue;
+ if ((vc.flag & VC_ACGT_ONLY) && !is_indel) {
+ int x;
+ if (b->ref[0] == 0 || b->ref[1] != 0) continue;
+ x = toupper(b->ref[0]);
+ if (x != 'A' && x != 'C' && x != 'G' && x != 'T') continue;
+ }
+ if (vc.bed && !bed_overlap(vc.bed, hin->ns[b->tid], b->pos, b->pos + strlen(b->ref))) continue;
+ if (tid >= 0) {
+ int l = strlen(b->ref);
+ l = b->pos + (l > 0? l : 1);
+ if (b->tid != tid || b->pos >= end) break;
+ if (!(l > begin && end > b->pos)) continue;
+ }
+ ++n_processed;
+ if (vc.flag & VC_QCALL) { // output QCALL format; STOP here
+ bcf_2qcall(hout, b);
+ continue;
+ }
+ if (vc.flag & VC_EM) bcf_em1(b, vc.n1, 0xff, em);
+ else {
+ int i;
+ for (i = 0; i < 9; ++i) em[i] = -1.;
+ }
+ if (vc.flag & (VC_CALL|VC_ADJLD)) bcf_gl2pl(b);
+ if (vc.flag & VC_CALL) { // call variants
+ bcf_p1rst_t pr;
+ int calret = bcf_p1_cal(b, (em[7] >= 0 && em[7] < vc.min_lrt), p1, &pr);
+ if (n_processed % 100000 == 0) {
+ fprintf(pysamerr, "[%s] %ld sites processed.\n", __func__, (long)n_processed);
+ bcf_p1_dump_afs(p1);
+ }
+ if (pr.p_ref >= vc.pref && (vc.flag & VC_VARONLY)) continue;
+ if (vc.n_perm && vc.n1 > 0 && pr.p_chi2 < vc.min_perm_p) { // permutation test
+ bcf_p1rst_t r;
+ int i, n = 0;
+ for (i = 0; i < vc.n_perm; ++i) {
+#ifdef BCF_PERM_LRT // LRT based permutation is much faster but less robust to artifacts
+ double x[9];
+ bcf_shuffle(b, seeds[i]);
+ bcf_em1(b, vc.n1, 1<<7, x);
+ if (x[7] < em[7]) ++n;
+#else
+ bcf_shuffle(b, seeds[i]);
+ bcf_p1_cal(b, 1, p1, &r);
+ if (pr.p_chi2 >= r.p_chi2) ++n;
+#endif
+ }
+ pr.perm_rank = n;
+ }
+ if (calret >= 0) update_bcf1(b, p1, &pr, vc.pref, vc.flag, em);
+ } else if (vc.flag & VC_EM) update_bcf1(b, 0, 0, 0, vc.flag, em);
+ if (vc.flag & VC_ADJLD) { // compute LD
+ double f[4], r2;
+ if ((r2 = bcf_pair_freq(blast, b, f)) >= 0) {
+ kstring_t s;
+ s.m = s.l = 0; s.s = 0;
+ if (*b->info) kputc(';', &s);
+ ksprintf(&s, "NEIR=%.3f;NEIF4=%.3f,%.3f,%.3f,%.3f", r2, f[0], f[1], f[2], f[3]);
+ bcf_append_info(b, s.s, s.l);
+ free(s.s);
+ }
+ bcf_cpy(blast, b);
+ }
+ if (vc.flag & VC_ANNO_MAX) bcf_anno_max(b);
+ if (vc.flag & VC_NO_GENO) { // do not output GENO fields
+ b->n_gi = 0;
+ b->fmt[0] = '\0';
+ b->l_str = b->fmt - b->str + 1;
+ } else bcf_fix_gt(b);
+ vcf_write(bout, hout, b);
+ }
+ if (vc.prior_file) free(vc.prior_file);
+ if (vc.flag & VC_CALL) bcf_p1_dump_afs(p1);
+ if (hin != hout) bcf_hdr_destroy(hout);
+ bcf_hdr_destroy(hin);
+ bcf_destroy(b); bcf_destroy(blast);
+ vcf_close(bp); vcf_close(bout);
+ if (vc.fn_dict) free(vc.fn_dict);
+ if (vc.ploidy) free(vc.ploidy);
+ if (vc.n_sub) {
+ int i;
+ for (i = 0; i < vc.n_sub; ++i) free(vc.subsam[i]);
+ free(vc.subsam); free(vc.sublist);
+ }
+ if (vc.bed) bed_destroy(vc.bed);
+ if (seeds) free(seeds);
+ if (p1) bcf_p1_destroy(p1);
+ return 0;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <string.h>
+#include <math.h>
+#include "bcf.h"
+#include "kmin.h"
+
+static double g_q2p[256];
+
+#define ITER_MAX 50
+#define ITER_TRY 10
+#define EPS 1e-5
+
+extern double kf_gammaq(double, double);
+
+/*
+ Generic routines
+ */
+// get the 3 genotype likelihoods
+static double *get_pdg3(const bcf1_t *b)
+{
+ double *pdg;
+ const uint8_t *PL = 0;
+ int i, PL_len = 0;
+ // initialize g_q2p if necessary
+ if (g_q2p[0] == 0.)
+ for (i = 0; i < 256; ++i)
+ g_q2p[i] = pow(10., -i / 10.);
+ // set PL and PL_len
+ for (i = 0; i < b->n_gi; ++i) {
+ if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ PL = (const uint8_t*)b->gi[i].data;
+ PL_len = b->gi[i].len;
+ break;
+ }
+ }
+ if (i == b->n_gi) return 0; // no PL
+ // fill pdg
+ pdg = malloc(3 * b->n_smpl * sizeof(double));
+ for (i = 0; i < b->n_smpl; ++i) {
+ const uint8_t *pi = PL + i * PL_len;
+ double *p = pdg + i * 3;
+ p[0] = g_q2p[pi[2]]; p[1] = g_q2p[pi[1]]; p[2] = g_q2p[pi[0]];
+ }
+ return pdg;
+}
+
+// estimate site allele frequency in a very naive and inaccurate way
+static double est_freq(int n, const double *pdg)
+{
+ int i, gcnt[3], tmp1;
+ // get a rough estimate of the genotype frequency
+ gcnt[0] = gcnt[1] = gcnt[2] = 0;
+ for (i = 0; i < n; ++i) {
+ const double *p = pdg + i * 3;
+ if (p[0] != 1. || p[1] != 1. || p[2] != 1.) {
+ int which = p[0] > p[1]? 0 : 1;
+ which = p[which] > p[2]? which : 2;
+ ++gcnt[which];
+ }
+ }
+ tmp1 = gcnt[0] + gcnt[1] + gcnt[2];
+ return (tmp1 == 0)? -1.0 : (.5 * gcnt[1] + gcnt[2]) / tmp1;
+}
+
+/*
+ Single-locus EM
+ */
+
+typedef struct {
+ int beg, end;
+ const double *pdg;
+} minaux1_t;
+
+static double prob1(double f, void *data)
+{
+ minaux1_t *a = (minaux1_t*)data;
+ double p = 1., l = 0., f3[3];
+ int i;
+// printf("brent %lg\n", f);
+ if (f < 0 || f > 1) return 1e300;
+ f3[0] = (1.-f)*(1.-f); f3[1] = 2.*f*(1.-f); f3[2] = f*f;
+ for (i = a->beg; i < a->end; ++i) {
+ const double *pdg = a->pdg + i * 3;
+ p *= pdg[0] * f3[0] + pdg[1] * f3[1] + pdg[2] * f3[2];
+ if (p < 1e-200) l -= log(p), p = 1.;
+ }
+ return l - log(p);
+}
+
+// one EM iteration for allele frequency estimate
+static double freq_iter(double *f, const double *_pdg, int beg, int end)
+{
+ double f0 = *f, f3[3], err;
+ int i;
+// printf("em %lg\n", *f);
+ f3[0] = (1.-f0)*(1.-f0); f3[1] = 2.*f0*(1.-f0); f3[2] = f0*f0;
+ for (i = beg, f0 = 0.; i < end; ++i) {
+ const double *pdg = _pdg + i * 3;
+ f0 += (pdg[1] * f3[1] + 2. * pdg[2] * f3[2])
+ / (pdg[0] * f3[0] + pdg[1] * f3[1] + pdg[2] * f3[2]);
+ }
+ f0 /= (end - beg) * 2;
+ err = fabs(f0 - *f);
+ *f = f0;
+ return err;
+}
+
+/* The following function combines EM and Brent's method. When the signal from
+ * the data is strong, EM is faster but sometimes, EM may converge very slowly.
+ * When this happens, we switch to Brent's method. The idea is learned from
+ * Rasmus Nielsen.
+ */
+static double freqml(double f0, int beg, int end, const double *pdg)
+{
+ int i;
+ double f;
+ for (i = 0, f = f0; i < ITER_TRY; ++i)
+ if (freq_iter(&f, pdg, beg, end) < EPS) break;
+ if (i == ITER_TRY) { // haven't converged yet; try Brent's method
+ minaux1_t a;
+ a.beg = beg; a.end = end; a.pdg = pdg;
+ kmin_brent(prob1, f0 == f? .5*f0 : f0, f, (void*)&a, EPS, &f);
+ }
+ return f;
+}
+
+// one EM iteration for genotype frequency estimate
+static double g3_iter(double g[3], const double *_pdg, int beg, int end)
+{
+ double err, gg[3];
+ int i;
+ gg[0] = gg[1] = gg[2] = 0.;
+// printf("%lg,%lg,%lg\n", g[0], g[1], g[2]);
+ for (i = beg; i < end; ++i) {
+ double sum, tmp[3];
+ const double *pdg = _pdg + i * 3;
+ tmp[0] = pdg[0] * g[0]; tmp[1] = pdg[1] * g[1]; tmp[2] = pdg[2] * g[2];
+ sum = (tmp[0] + tmp[1] + tmp[2]) * (end - beg);
+ gg[0] += tmp[0] / sum; gg[1] += tmp[1] / sum; gg[2] += tmp[2] / sum;
+ }
+ err = fabs(gg[0] - g[0]) > fabs(gg[1] - g[1])? fabs(gg[0] - g[0]) : fabs(gg[1] - g[1]);
+ err = err > fabs(gg[2] - g[2])? err : fabs(gg[2] - g[2]);
+ g[0] = gg[0]; g[1] = gg[1]; g[2] = gg[2];
+ return err;
+}
+
+// perform likelihood ratio test
+static double lk_ratio_test(int n, int n1, const double *pdg, double f3[3][3])
+{
+ double r;
+ int i;
+ for (i = 0, r = 1.; i < n1; ++i) {
+ const double *p = pdg + i * 3;
+ r *= (p[0] * f3[1][0] + p[1] * f3[1][1] + p[2] * f3[1][2])
+ / (p[0] * f3[0][0] + p[1] * f3[0][1] + p[2] * f3[0][2]);
+ }
+ for (; i < n; ++i) {
+ const double *p = pdg + i * 3;
+ r *= (p[0] * f3[2][0] + p[1] * f3[2][1] + p[2] * f3[2][2])
+ / (p[0] * f3[0][0] + p[1] * f3[0][1] + p[2] * f3[0][2]);
+ }
+ return r;
+}
+
+// x[0]: ref frequency
+// x[1..3]: alt-alt, alt-ref, ref-ref frequenc
+// x[4]: HWE P-value
+// x[5..6]: group1 freq, group2 freq
+// x[7]: 1-degree P-value
+// x[8]: 2-degree P-value
+int bcf_em1(const bcf1_t *b, int n1, int flag, double x[9])
+{
+ double *pdg;
+ int i, n, n2;
+ if (b->n_alleles < 2) return -1; // one allele only
+ // initialization
+ if (n1 < 0 || n1 > b->n_smpl) n1 = 0;
+ if (flag & 1<<7) flag |= 7<<5; // compute group freq if LRT is required
+ if (flag & 0xf<<1) flag |= 0xf<<1;
+ n = b->n_smpl; n2 = n - n1;
+ pdg = get_pdg3(b);
+ if (pdg == 0) return -1;
+ for (i = 0; i < 9; ++i) x[i] = -1.;
+ {
+ if ((x[0] = est_freq(n, pdg)) < 0.) {
+ free(pdg);
+ return -1; // no data
+ }
+ x[0] = freqml(x[0], 0, n, pdg);
+ }
+ if (flag & (0xf<<1|1<<8)) { // estimate the genotype frequency and test HWE
+ double *g = x + 1, f3[3], r;
+ f3[0] = g[0] = (1 - x[0]) * (1 - x[0]);
+ f3[1] = g[1] = 2 * x[0] * (1 - x[0]);
+ f3[2] = g[2] = x[0] * x[0];
+ for (i = 0; i < ITER_MAX; ++i)
+ if (g3_iter(g, pdg, 0, n) < EPS) break;
+ // Hardy-Weinberg equilibrium (HWE)
+ for (i = 0, r = 1.; i < n; ++i) {
+ double *p = pdg + i * 3;
+ r *= (p[0] * g[0] + p[1] * g[1] + p[2] * g[2]) / (p[0] * f3[0] + p[1] * f3[1] + p[2] * f3[2]);
+ }
+ x[4] = kf_gammaq(.5, log(r));
+ }
+ if ((flag & 7<<5) && n1 > 0 && n1 < n) { // group frequency
+ x[5] = freqml(x[0], 0, n1, pdg);
+ x[6] = freqml(x[0], n1, n, pdg);
+ }
+ if ((flag & 1<<7) && n1 > 0 && n1 < n) { // 1-degree P-value
+ double f[3], f3[3][3];
+ f[0] = x[0]; f[1] = x[5]; f[2] = x[6];
+ for (i = 0; i < 3; ++i)
+ f3[i][0] = (1-f[i])*(1-f[i]), f3[i][1] = 2*f[i]*(1-f[i]), f3[i][2] = f[i]*f[i];
+ x[7] = kf_gammaq(.5, log(lk_ratio_test(n, n1, pdg, f3)));
+ }
+ if ((flag & 1<<8) && n1 > 0 && n1 < n) { // 2-degree P-value
+ double g[3][3];
+ for (i = 0; i < 3; ++i) memcpy(g[i], x + 1, 3 * sizeof(double));
+ for (i = 0; i < ITER_MAX; ++i)
+ if (g3_iter(g[1], pdg, 0, n1) < EPS) break;
+ for (i = 0; i < ITER_MAX; ++i)
+ if (g3_iter(g[2], pdg, n1, n) < EPS) break;
+ x[8] = kf_gammaq(1., log(lk_ratio_test(n, n1, pdg, g)));
+ }
+ // free
+ free(pdg);
+ return 0;
+}
+
+/*
+ Two-locus EM (LD)
+ */
+
+#define _G1(h, k) ((h>>1&1) + (k>>1&1))
+#define _G2(h, k) ((h&1) + (k&1))
+
+// 0: the previous site; 1: the current site
+static int pair_freq_iter(int n, double *pdg[2], double f[4])
+{
+ double ff[4];
+ int i, k, h;
+// printf("%lf,%lf,%lf,%lf\n", f[0], f[1], f[2], f[3]);
+ memset(ff, 0, 4 * sizeof(double));
+ for (i = 0; i < n; ++i) {
+ double *p[2], sum, tmp;
+ p[0] = pdg[0] + i * 3; p[1] = pdg[1] + i * 3;
+ for (k = 0, sum = 0.; k < 4; ++k)
+ for (h = 0; h < 4; ++h)
+ sum += f[k] * f[h] * p[0][_G1(k,h)] * p[1][_G2(k,h)];
+ for (k = 0; k < 4; ++k) {
+ tmp = f[0] * (p[0][_G1(0,k)] * p[1][_G2(0,k)] + p[0][_G1(k,0)] * p[1][_G2(k,0)])
+ + f[1] * (p[0][_G1(1,k)] * p[1][_G2(1,k)] + p[0][_G1(k,1)] * p[1][_G2(k,1)])
+ + f[2] * (p[0][_G1(2,k)] * p[1][_G2(2,k)] + p[0][_G1(k,2)] * p[1][_G2(k,2)])
+ + f[3] * (p[0][_G1(3,k)] * p[1][_G2(3,k)] + p[0][_G1(k,3)] * p[1][_G2(k,3)]);
+ ff[k] += f[k] * tmp / sum;
+ }
+ }
+ for (k = 0; k < 4; ++k) f[k] = ff[k] / (2 * n);
+ return 0;
+}
+
+double bcf_pair_freq(const bcf1_t *b0, const bcf1_t *b1, double f[4])
+{
+ const bcf1_t *b[2];
+ int i, j, n_smpl;
+ double *pdg[2], flast[4], r, f0[2];
+ // initialize others
+ if (b0->n_smpl != b1->n_smpl) return -1; // different number of samples
+ n_smpl = b0->n_smpl;
+ b[0] = b0; b[1] = b1;
+ f[0] = f[1] = f[2] = f[3] = -1.;
+ if (b[0]->n_alleles < 2 || b[1]->n_alleles < 2) return -1; // one allele only
+ pdg[0] = get_pdg3(b0); pdg[1] = get_pdg3(b1);
+ if (pdg[0] == 0 || pdg[1] == 0) {
+ free(pdg[0]); free(pdg[1]);
+ return -1;
+ }
+ // set the initial value
+ f0[0] = est_freq(n_smpl, pdg[0]);
+ f0[1] = est_freq(n_smpl, pdg[1]);
+ f[0] = (1 - f0[0]) * (1 - f0[1]); f[3] = f0[0] * f0[1];
+ f[1] = (1 - f0[0]) * f0[1]; f[2] = f0[0] * (1 - f0[1]);
+ // iteration
+ for (j = 0; j < ITER_MAX; ++j) {
+ double eps = 0;
+ memcpy(flast, f, 4 * sizeof(double));
+ pair_freq_iter(n_smpl, pdg, f);
+ for (i = 0; i < 4; ++i) {
+ double x = fabs(f[i] - flast[i]);
+ if (x > eps) eps = x;
+ }
+ if (eps < EPS) break;
+ }
+ // free
+ free(pdg[0]); free(pdg[1]);
+ { // calculate r^2
+ double p[2], q[2], D;
+ p[0] = f[0] + f[1]; q[0] = 1 - p[0];
+ p[1] = f[0] + f[2]; q[1] = 1 - p[1];
+ D = f[0] * f[3] - f[1] * f[2];
+ r = sqrt(D * D / (p[0] * p[1] * q[0] * q[1]));
+// printf("R(%lf,%lf,%lf,%lf)=%lf\n", f[0], f[1], f[2], f[3], r);
+ if (isnan(r)) r = -1.;
+ }
+ return r;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include <stdlib.h>
+
+/* This program is implemented with ideas from this web page:
+ *
+ * http://www.langsrud.com/fisher.htm
+ */
+
+// log\binom{n}{k}
+static double lbinom(int n, int k)
+{
+ if (k == 0 || n == k) return 0;
+ return lgamma(n+1) - lgamma(k+1) - lgamma(n-k+1);
+}
+
+// n11 n12 | n1_
+// n21 n22 | n2_
+//-----------+----
+// n_1 n_2 | n
+
+// hypergeometric distribution
+static double hypergeo(int n11, int n1_, int n_1, int n)
+{
+ return exp(lbinom(n1_, n11) + lbinom(n-n1_, n_1-n11) - lbinom(n, n_1));
+}
+
+typedef struct {
+ int n11, n1_, n_1, n;
+ double p;
+} hgacc_t;
+
+// incremental version of hypergenometric distribution
+static double hypergeo_acc(int n11, int n1_, int n_1, int n, hgacc_t *aux)
+{
+ if (n1_ || n_1 || n) {
+ aux->n11 = n11; aux->n1_ = n1_; aux->n_1 = n_1; aux->n = n;
+ } else { // then only n11 changed; the rest fixed
+ if (n11%11 && n11 + aux->n - aux->n1_ - aux->n_1) {
+ if (n11 == aux->n11 + 1) { // incremental
+ aux->p *= (double)(aux->n1_ - aux->n11) / n11
+ * (aux->n_1 - aux->n11) / (n11 + aux->n - aux->n1_ - aux->n_1);
+ aux->n11 = n11;
+ return aux->p;
+ }
+ if (n11 == aux->n11 - 1) { // incremental
+ aux->p *= (double)aux->n11 / (aux->n1_ - n11)
+ * (aux->n11 + aux->n - aux->n1_ - aux->n_1) / (aux->n_1 - n11);
+ aux->n11 = n11;
+ return aux->p;
+ }
+ }
+ aux->n11 = n11;
+ }
+ aux->p = hypergeo(aux->n11, aux->n1_, aux->n_1, aux->n);
+ return aux->p;
+}
+
+double kt_fisher_exact(int n11, int n12, int n21, int n22, double *_left, double *_right, double *two)
+{
+ int i, j, max, min;
+ double p, q, left, right;
+ hgacc_t aux;
+ int n1_, n_1, n;
+
+ n1_ = n11 + n12; n_1 = n11 + n21; n = n11 + n12 + n21 + n22; // calculate n1_, n_1 and n
+ max = (n_1 < n1_) ? n_1 : n1_; // max n11, for right tail
+ min = n1_ + n_1 - n;
+ if (min < 0) min = 0; // min n11, for left tail
+ *two = *_left = *_right = 1.;
+ if (min == max) return 1.; // no need to do test
+ q = hypergeo_acc(n11, n1_, n_1, n, &aux); // the probability of the current table
+ // left tail
+ p = hypergeo_acc(min, 0, 0, 0, &aux);
+ for (left = 0., i = min + 1; p < 0.99999999 * q; ++i) // loop until underflow
+ left += p, p = hypergeo_acc(i, 0, 0, 0, &aux);
+ --i;
+ if (p < 1.00000001 * q) left += p;
+ else --i;
+ // right tail
+ p = hypergeo_acc(max, 0, 0, 0, &aux);
+ for (right = 0., j = max - 1; p < 0.99999999 * q; --j) // loop until underflow
+ right += p, p = hypergeo_acc(j, 0, 0, 0, &aux);
+ ++j;
+ if (p < 1.00000001 * q) right += p;
+ else ++j;
+ // two-tail
+ *two = left + right;
+ if (*two > 1.) *two = 1.;
+ // adjust left and right
+ if (abs(i - n11) < abs(j - n11)) right = 1. - left + q;
+ else left = 1.0 - right + q;
+ *_left = left; *_right = right;
+ return q;
+}
+
+#ifdef FET_MAIN
+#include <stdio.h>
+
+int main(int argc, char *argv[])
+{
+ char id[1024];
+ int n11, n12, n21, n22;
+ double left, right, twotail, prob;
+
+ while (scanf("%s%d%d%d%d", id, &n11, &n12, &n21, &n22) == 5) {
+ prob = kt_fisher_exact(n11, n12, n21, n22, &left, &right, &twotail);
+ printf("%s\t%d\t%d\t%d\t%d\t%.6g\t%.6g\t%.6g\t%.6g\n", id, n11, n12, n21, n22,
+ prob, left, right, twotail);
+ }
+ return 0;
+}
+#endif
--- /dev/null
+#include "pysam.h"
+
+#include <assert.h>
+#include <ctype.h>
+#include <sys/stat.h>
+#include "bam_endian.h"
+#include "kstring.h"
+#include "bcf.h"
+#ifdef _USE_KNETFILE
+#include "knetfile.h"
+#endif
+
+#define TAD_LIDX_SHIFT 13
+
+typedef struct {
+ int32_t n, m;
+ uint64_t *offset;
+} bcf_lidx_t;
+
+struct __bcf_idx_t {
+ int32_t n;
+ bcf_lidx_t *index2;
+};
+
+/************
+ * indexing *
+ ************/
+
+static inline void insert_offset2(bcf_lidx_t *index2, int _beg, int _end, uint64_t offset)
+{
+ int i, beg, end;
+ beg = _beg >> TAD_LIDX_SHIFT;
+ end = (_end - 1) >> TAD_LIDX_SHIFT;
+ if (index2->m < end + 1) {
+ int old_m = index2->m;
+ index2->m = end + 1;
+ kroundup32(index2->m);
+ index2->offset = (uint64_t*)realloc(index2->offset, index2->m * 8);
+ memset(index2->offset + old_m, 0, 8 * (index2->m - old_m));
+ }
+ if (beg == end) {
+ if (index2->offset[beg] == 0) index2->offset[beg] = offset;
+ } else {
+ for (i = beg; i <= end; ++i)
+ if (index2->offset[i] == 0) index2->offset[i] = offset;
+ }
+ if (index2->n < end + 1) index2->n = end + 1;
+}
+
+bcf_idx_t *bcf_idx_core(bcf_t *bp, bcf_hdr_t *h)
+{
+ bcf_idx_t *idx;
+ int32_t last_coor, last_tid;
+ uint64_t last_off;
+ kstring_t *str;
+ BGZF *fp = bp->fp;
+ bcf1_t *b;
+ int ret;
+
+ b = calloc(1, sizeof(bcf1_t));
+ str = calloc(1, sizeof(kstring_t));
+ idx = (bcf_idx_t*)calloc(1, sizeof(bcf_idx_t));
+ idx->n = h->n_ref;
+ idx->index2 = calloc(h->n_ref, sizeof(bcf_lidx_t));
+
+ last_tid = 0xffffffffu;
+ last_off = bgzf_tell(fp); last_coor = 0xffffffffu;
+ while ((ret = bcf_read(bp, h, b)) > 0) {
+ int end, tmp;
+ if (last_tid != b->tid) { // change of chromosomes
+ last_tid = b->tid;
+ } else if (last_coor > b->pos) {
+ fprintf(pysamerr, "[bcf_idx_core] the input is out of order\n");
+ free(str->s); free(str); free(idx); bcf_destroy(b);
+ return 0;
+ }
+ tmp = strlen(b->ref);
+ end = b->pos + (tmp > 0? tmp : 1);
+ insert_offset2(&idx->index2[b->tid], b->pos, end, last_off);
+ last_off = bgzf_tell(fp);
+ last_coor = b->pos;
+ }
+ free(str->s); free(str); bcf_destroy(b);
+ return idx;
+}
+
+void bcf_idx_destroy(bcf_idx_t *idx)
+{
+ int i;
+ if (idx == 0) return;
+ for (i = 0; i < idx->n; ++i) free(idx->index2[i].offset);
+ free(idx->index2);
+ free(idx);
+}
+
+/******************
+ * index file I/O *
+ ******************/
+
+void bcf_idx_save(const bcf_idx_t *idx, BGZF *fp)
+{
+ int32_t i, ti_is_be;
+ ti_is_be = bam_is_big_endian();
+ bgzf_write(fp, "BCI\4", 4);
+ if (ti_is_be) {
+ uint32_t x = idx->n;
+ bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ } else bgzf_write(fp, &idx->n, 4);
+ for (i = 0; i < idx->n; ++i) {
+ bcf_lidx_t *index2 = idx->index2 + i;
+ // write linear index (index2)
+ if (ti_is_be) {
+ int x = index2->n;
+ bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ } else bgzf_write(fp, &index2->n, 4);
+ if (ti_is_be) { // big endian
+ int x;
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ bgzf_write(fp, index2->offset, 8 * index2->n);
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ } else bgzf_write(fp, index2->offset, 8 * index2->n);
+ }
+}
+
+static bcf_idx_t *bcf_idx_load_core(BGZF *fp)
+{
+ int i, ti_is_be;
+ char magic[4];
+ bcf_idx_t *idx;
+ ti_is_be = bam_is_big_endian();
+ if (fp == 0) {
+ fprintf(pysamerr, "[%s] fail to load index.\n", __func__);
+ return 0;
+ }
+ bgzf_read(fp, magic, 4);
+ if (strncmp(magic, "BCI\4", 4)) {
+ fprintf(pysamerr, "[%s] wrong magic number.\n", __func__);
+ return 0;
+ }
+ idx = (bcf_idx_t*)calloc(1, sizeof(bcf_idx_t));
+ bgzf_read(fp, &idx->n, 4);
+ if (ti_is_be) bam_swap_endian_4p(&idx->n);
+ idx->index2 = (bcf_lidx_t*)calloc(idx->n, sizeof(bcf_lidx_t));
+ for (i = 0; i < idx->n; ++i) {
+ bcf_lidx_t *index2 = idx->index2 + i;
+ int j;
+ bgzf_read(fp, &index2->n, 4);
+ if (ti_is_be) bam_swap_endian_4p(&index2->n);
+ index2->m = index2->n;
+ index2->offset = (uint64_t*)calloc(index2->m, 8);
+ bgzf_read(fp, index2->offset, index2->n * 8);
+ if (ti_is_be)
+ for (j = 0; j < index2->n; ++j) bam_swap_endian_8p(&index2->offset[j]);
+ }
+ return idx;
+}
+
+bcf_idx_t *bcf_idx_load_local(const char *fnidx)
+{
+ BGZF *fp;
+ fp = bgzf_open(fnidx, "r");
+ if (fp) {
+ bcf_idx_t *idx = bcf_idx_load_core(fp);
+ bgzf_close(fp);
+ return idx;
+ } else return 0;
+}
+
+#ifdef _USE_KNETFILE
+static void download_from_remote(const char *url)
+{
+ const int buf_size = 1 * 1024 * 1024;
+ char *fn;
+ FILE *fp;
+ uint8_t *buf;
+ knetFile *fp_remote;
+ int l;
+ if (strstr(url, "ftp://") != url && strstr(url, "http://") != url) return;
+ l = strlen(url);
+ for (fn = (char*)url + l - 1; fn >= url; --fn)
+ if (*fn == '/') break;
+ ++fn; // fn now points to the file name
+ fp_remote = knet_open(url, "r");
+ if (fp_remote == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to open remote file.\n");
+ return;
+ }
+ if ((fp = fopen(fn, "w")) == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to create file in the working directory.\n");
+ knet_close(fp_remote);
+ return;
+ }
+ buf = (uint8_t*)calloc(buf_size, 1);
+ while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
+ fwrite(buf, 1, l, fp);
+ free(buf);
+ fclose(fp);
+ knet_close(fp_remote);
+}
+#else
+static void download_from_remote(const char *url)
+{
+ return;
+}
+#endif
+
+static char *get_local_version(const char *fn)
+{
+ struct stat sbuf;
+ char *fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcat(strcpy(fnidx, fn), ".bci");
+ if ((strstr(fnidx, "ftp://") == fnidx || strstr(fnidx, "http://") == fnidx)) {
+ char *p, *url;
+ int l = strlen(fnidx);
+ for (p = fnidx + l - 1; p >= fnidx; --p)
+ if (*p == '/') break;
+ url = fnidx; fnidx = strdup(p + 1);
+ if (stat(fnidx, &sbuf) == 0) {
+ free(url);
+ return fnidx;
+ }
+ fprintf(pysamerr, "[%s] downloading the index file...\n", __func__);
+ download_from_remote(url);
+ free(url);
+ }
+ if (stat(fnidx, &sbuf) == 0) return fnidx;
+ free(fnidx); return 0;
+}
+
+bcf_idx_t *bcf_idx_load(const char *fn)
+{
+ bcf_idx_t *idx;
+ char *fname = get_local_version(fn);
+ if (fname == 0) return 0;
+ idx = bcf_idx_load_local(fname);
+ free(fname);
+ return idx;
+}
+
+int bcf_idx_build2(const char *fn, const char *_fnidx)
+{
+ char *fnidx;
+ BGZF *fpidx;
+ bcf_t *bp;
+ bcf_idx_t *idx;
+ bcf_hdr_t *h;
+ if ((bp = bcf_open(fn, "r")) == 0) {
+ fprintf(pysamerr, "[bcf_idx_build2] fail to open the BAM file.\n");
+ return -1;
+ }
+ h = bcf_hdr_read(bp);
+ idx = bcf_idx_core(bp, h);
+ bcf_close(bp);
+ if (_fnidx == 0) {
+ fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcpy(fnidx, fn); strcat(fnidx, ".bci");
+ } else fnidx = strdup(_fnidx);
+ fpidx = bgzf_open(fnidx, "w");
+ if (fpidx == 0) {
+ fprintf(pysamerr, "[bcf_idx_build2] fail to create the index file.\n");
+ free(fnidx);
+ return -1;
+ }
+ bcf_idx_save(idx, fpidx);
+ bcf_idx_destroy(idx);
+ bgzf_close(fpidx);
+ free(fnidx);
+ return 0;
+}
+
+int bcf_idx_build(const char *fn)
+{
+ return bcf_idx_build2(fn, 0);
+}
+
+/********************************************
+ * parse a region in the format chr:beg-end *
+ ********************************************/
+
+int bcf_parse_region(void *str2id, const char *str, int *tid, int *begin, int *end)
+{
+ char *s, *p;
+ int i, l, k;
+ l = strlen(str);
+ p = s = (char*)malloc(l+1);
+ /* squeeze out "," */
+ for (i = k = 0; i != l; ++i)
+ if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
+ s[k] = 0;
+ for (i = 0; i != k; ++i) if (s[i] == ':') break;
+ s[i] = 0;
+ if ((*tid = bcf_str2id(str2id, s)) < 0) {
+ free(s);
+ return -1;
+ }
+ if (i == k) { /* dump the whole sequence */
+ *begin = 0; *end = 1<<29; free(s);
+ return 0;
+ }
+ for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
+ *begin = atoi(p);
+ if (i < k) {
+ p = s + i + 1;
+ *end = atoi(p);
+ } else *end = 1<<29;
+ if (*begin > 0) --*begin;
+ free(s);
+ if (*begin > *end) return -1;
+ return 0;
+}
+
+/*******************************
+ * retrieve a specified region *
+ *******************************/
+
+uint64_t bcf_idx_query(const bcf_idx_t *idx, int tid, int beg)
+{
+ uint64_t min_off, *offset;
+ int i;
+ if (beg < 0) beg = 0;
+ offset = idx->index2[tid].offset;
+ for (i = beg>>TAD_LIDX_SHIFT; i < idx->index2[tid].n && offset[i] == 0; ++i);
+ min_off = (i == idx->index2[tid].n)? offset[idx->index2[tid].n-1] : offset[i];
+ return min_off;
+}
+
+int bcf_main_index(int argc, char *argv[])
+{
+ if (argc == 1) {
+ fprintf(pysamerr, "Usage: bcftools index <in.bcf>\n");
+ return 1;
+ }
+ bcf_idx_build(argv[1]);
+ return 0;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+
+
+/* Log gamma function
+ * \log{\Gamma(z)}
+ * AS245, 2nd algorithm, http://lib.stat.cmu.edu/apstat/245
+ */
+double kf_lgamma(double z)
+{
+ double x = 0;
+ x += 0.1659470187408462e-06 / (z+7);
+ x += 0.9934937113930748e-05 / (z+6);
+ x -= 0.1385710331296526 / (z+5);
+ x += 12.50734324009056 / (z+4);
+ x -= 176.6150291498386 / (z+3);
+ x += 771.3234287757674 / (z+2);
+ x -= 1259.139216722289 / (z+1);
+ x += 676.5203681218835 / z;
+ x += 0.9999999999995183;
+ return log(x) - 5.58106146679532777 - z + (z-0.5) * log(z+6.5);
+}
+
+/* complementary error function
+ * \frac{2}{\sqrt{\pi}} \int_x^{\infty} e^{-t^2} dt
+ * AS66, 2nd algorithm, http://lib.stat.cmu.edu/apstat/66
+ */
+double kf_erfc(double x)
+{
+ const double p0 = 220.2068679123761;
+ const double p1 = 221.2135961699311;
+ const double p2 = 112.0792914978709;
+ const double p3 = 33.912866078383;
+ const double p4 = 6.37396220353165;
+ const double p5 = .7003830644436881;
+ const double p6 = .03526249659989109;
+ const double q0 = 440.4137358247522;
+ const double q1 = 793.8265125199484;
+ const double q2 = 637.3336333788311;
+ const double q3 = 296.5642487796737;
+ const double q4 = 86.78073220294608;
+ const double q5 = 16.06417757920695;
+ const double q6 = 1.755667163182642;
+ const double q7 = .08838834764831844;
+ double expntl, z, p;
+ z = fabs(x) * M_SQRT2;
+ if (z > 37.) return x > 0.? 0. : 2.;
+ expntl = exp(z * z * - .5);
+ if (z < 10. / M_SQRT2) // for small z
+ p = expntl * ((((((p6 * z + p5) * z + p4) * z + p3) * z + p2) * z + p1) * z + p0)
+ / (((((((q7 * z + q6) * z + q5) * z + q4) * z + q3) * z + q2) * z + q1) * z + q0);
+ else p = expntl / 2.506628274631001 / (z + 1. / (z + 2. / (z + 3. / (z + 4. / (z + .65)))));
+ return x > 0.? 2. * p : 2. * (1. - p);
+}
+
+/* The following computes regularized incomplete gamma functions.
+ * Formulas are taken from Wiki, with additional input from Numerical
+ * Recipes in C (for modified Lentz's algorithm) and AS245
+ * (http://lib.stat.cmu.edu/apstat/245).
+ *
+ * A good online calculator is available at:
+ *
+ * http://www.danielsoper.com/statcalc/calc23.aspx
+ *
+ * It calculates upper incomplete gamma function, which equals
+ * kf_gammaq(s,z)*tgamma(s).
+ */
+
+#define KF_GAMMA_EPS 1e-14
+#define KF_TINY 1e-290
+
+// regularized lower incomplete gamma function, by series expansion
+static double _kf_gammap(double s, double z)
+{
+ double sum, x;
+ int k;
+ for (k = 1, sum = x = 1.; k < 100; ++k) {
+ sum += (x *= z / (s + k));
+ if (x / sum < KF_GAMMA_EPS) break;
+ }
+ return exp(s * log(z) - z - kf_lgamma(s + 1.) + log(sum));
+}
+// regularized upper incomplete gamma function, by continued fraction
+static double _kf_gammaq(double s, double z)
+{
+ int j;
+ double C, D, f;
+ f = 1. + z - s; C = f; D = 0.;
+ // Modified Lentz's algorithm for computing continued fraction
+ // See Numerical Recipes in C, 2nd edition, section 5.2
+ for (j = 1; j < 100; ++j) {
+ double a = j * (s - j), b = (j<<1) + 1 + z - s, d;
+ D = b + a * D;
+ if (D < KF_TINY) D = KF_TINY;
+ C = b + a / C;
+ if (C < KF_TINY) C = KF_TINY;
+ D = 1. / D;
+ d = C * D;
+ f *= d;
+ if (fabs(d - 1.) < KF_GAMMA_EPS) break;
+ }
+ return exp(s * log(z) - z - kf_lgamma(s) - log(f));
+}
+
+double kf_gammap(double s, double z)
+{
+ return z <= 1. || z < s? _kf_gammap(s, z) : 1. - _kf_gammaq(s, z);
+}
+
+double kf_gammaq(double s, double z)
+{
+ return z <= 1. || z < s? 1. - _kf_gammap(s, z) : _kf_gammaq(s, z);
+}
+
+/* Regularized incomplete beta function. The method is taken from
+ * Numerical Recipe in C, 2nd edition, section 6.4. The following web
+ * page calculates the incomplete beta function, which equals
+ * kf_betai(a,b,x) * gamma(a) * gamma(b) / gamma(a+b):
+ *
+ * http://www.danielsoper.com/statcalc/calc36.aspx
+ */
+static double kf_betai_aux(double a, double b, double x)
+{
+ double C, D, f;
+ int j;
+ if (x == 0.) return 0.;
+ if (x == 1.) return 1.;
+ f = 1.; C = f; D = 0.;
+ // Modified Lentz's algorithm for computing continued fraction
+ for (j = 1; j < 200; ++j) {
+ double aa, d;
+ int m = j>>1;
+ aa = (j&1)? -(a + m) * (a + b + m) * x / ((a + 2*m) * (a + 2*m + 1))
+ : m * (b - m) * x / ((a + 2*m - 1) * (a + 2*m));
+ D = 1. + aa * D;
+ if (D < KF_TINY) D = KF_TINY;
+ C = 1. + aa / C;
+ if (C < KF_TINY) C = KF_TINY;
+ D = 1. / D;
+ d = C * D;
+ f *= d;
+ if (fabs(d - 1.) < KF_GAMMA_EPS) break;
+ }
+ return exp(kf_lgamma(a+b) - kf_lgamma(a) - kf_lgamma(b) + a * log(x) + b * log(1.-x)) / a / f;
+}
+double kf_betai(double a, double b, double x)
+{
+ return x < (a + 1.) / (a + b + 2.)? kf_betai_aux(a, b, x) : 1. - kf_betai_aux(b, a, 1. - x);
+}
+
+#ifdef KF_MAIN
+#include <stdio.h>
+int main(int argc, char *argv[])
+{
+ double x = 5.5, y = 3;
+ double a, b;
+ printf("erfc(%lg): %lg, %lg\n", x, erfc(x), kf_erfc(x));
+ printf("upper-gamma(%lg,%lg): %lg\n", x, y, kf_gammaq(y, x)*tgamma(y));
+ a = 2; b = 2; x = 0.5;
+ printf("incomplete-beta(%lg,%lg,%lg): %lg\n", a, b, x, kf_betai(a, b, x) / exp(kf_lgamma(a+b) - kf_lgamma(a) - kf_lgamma(b)));
+ return 0;
+}
+#endif
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008, 2010 by Attractive Chaos <attractor@live.co.uk>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+/* Hooke-Jeeves algorithm for nonlinear minimization
+
+ Based on the pseudocodes by Bell and Pike (CACM 9(9):684-685), and
+ the revision by Tomlin and Smith (CACM 12(11):637-638). Both of the
+ papers are comments on Kaupe's Algorithm 178 "Direct Search" (ACM
+ 6(6):313-314). The original algorithm was designed by Hooke and
+ Jeeves (ACM 8:212-229). This program is further revised according to
+ Johnson's implementation at Netlib (opt/hooke.c).
+
+ Hooke-Jeeves algorithm is very simple and it works quite well on a
+ few examples. However, it might fail to converge due to its heuristic
+ nature. A possible improvement, as is suggested by Johnson, may be to
+ choose a small r at the beginning to quickly approach to the minimum
+ and a large r at later step to hit the minimum.
+ */
+
+#include <stdlib.h>
+#include <string.h>
+#include <math.h>
+#include "kmin.h"
+
+static double __kmin_hj_aux(kmin_f func, int n, double *x1, void *data, double fx1, double *dx, int *n_calls)
+{
+ int k, j = *n_calls;
+ double ftmp;
+ for (k = 0; k != n; ++k) {
+ x1[k] += dx[k];
+ ftmp = func(n, x1, data); ++j;
+ if (ftmp < fx1) fx1 = ftmp;
+ else { /* search the opposite direction */
+ dx[k] = 0.0 - dx[k];
+ x1[k] += dx[k] + dx[k];
+ ftmp = func(n, x1, data); ++j;
+ if (ftmp < fx1) fx1 = ftmp;
+ else x1[k] -= dx[k]; /* back to the original x[k] */
+ }
+ }
+ *n_calls = j;
+ return fx1; /* here: fx1=f(n,x1) */
+}
+
+double kmin_hj(kmin_f func, int n, double *x, void *data, double r, double eps, int max_calls)
+{
+ double fx, fx1, *x1, *dx, radius;
+ int k, n_calls = 0;
+ x1 = (double*)calloc(n, sizeof(double));
+ dx = (double*)calloc(n, sizeof(double));
+ for (k = 0; k != n; ++k) { /* initial directions, based on MGJ */
+ dx[k] = fabs(x[k]) * r;
+ if (dx[k] == 0) dx[k] = r;
+ }
+ radius = r;
+ fx1 = fx = func(n, x, data); ++n_calls;
+ for (;;) {
+ memcpy(x1, x, n * sizeof(double)); /* x1 = x */
+ fx1 = __kmin_hj_aux(func, n, x1, data, fx, dx, &n_calls);
+ while (fx1 < fx) {
+ for (k = 0; k != n; ++k) {
+ double t = x[k];
+ dx[k] = x1[k] > x[k]? fabs(dx[k]) : 0.0 - fabs(dx[k]);
+ x[k] = x1[k];
+ x1[k] = x1[k] + x1[k] - t;
+ }
+ fx = fx1;
+ if (n_calls >= max_calls) break;
+ fx1 = func(n, x1, data); ++n_calls;
+ fx1 = __kmin_hj_aux(func, n, x1, data, fx1, dx, &n_calls);
+ if (fx1 >= fx) break;
+ for (k = 0; k != n; ++k)
+ if (fabs(x1[k] - x[k]) > .5 * fabs(dx[k])) break;
+ if (k == n) break;
+ }
+ if (radius >= eps) {
+ if (n_calls >= max_calls) break;
+ radius *= r;
+ for (k = 0; k != n; ++k) dx[k] *= r;
+ } else break; /* converge */
+ }
+ free(x1); free(dx);
+ return fx1;
+}
+
+// I copied this function somewhere several years ago with some of my modifications, but I forgot the source.
+double kmin_brent(kmin1_f func, double a, double b, void *data, double tol, double *xmin)
+{
+ double bound, u, r, q, fu, tmp, fa, fb, fc, c;
+ const double gold1 = 1.6180339887;
+ const double gold2 = 0.3819660113;
+ const double tiny = 1e-20;
+ const int max_iter = 100;
+
+ double e, d, w, v, mid, tol1, tol2, p, eold, fv, fw;
+ int iter;
+
+ fa = func(a, data); fb = func(b, data);
+ if (fb > fa) { // swap, such that f(a) > f(b)
+ tmp = a; a = b; b = tmp;
+ tmp = fa; fa = fb; fb = tmp;
+ }
+ c = b + gold1 * (b - a), fc = func(c, data); // golden section extrapolation
+ while (fb > fc) {
+ bound = b + 100.0 * (c - b); // the farthest point where we want to go
+ r = (b - a) * (fb - fc);
+ q = (b - c) * (fb - fa);
+ if (fabs(q - r) < tiny) { // avoid 0 denominator
+ tmp = q > r? tiny : 0.0 - tiny;
+ } else tmp = q - r;
+ u = b - ((b - c) * q - (b - a) * r) / (2.0 * tmp); // u is the parabolic extrapolation point
+ if ((b > u && u > c) || (b < u && u < c)) { // u lies between b and c
+ fu = func(u, data);
+ if (fu < fc) { // (b,u,c) bracket the minimum
+ a = b; b = u; fa = fb; fb = fu;
+ break;
+ } else if (fu > fb) { // (a,b,u) bracket the minimum
+ c = u; fc = fu;
+ break;
+ }
+ u = c + gold1 * (c - b); fu = func(u, data); // golden section extrapolation
+ } else if ((c > u && u > bound) || (c < u && u < bound)) { // u lies between c and bound
+ fu = func(u, data);
+ if (fu < fc) { // fb > fc > fu
+ b = c; c = u; u = c + gold1 * (c - b);
+ fb = fc; fc = fu; fu = func(u, data);
+ } else { // (b,c,u) bracket the minimum
+ a = b; b = c; c = u;
+ fa = fb; fb = fc; fc = fu;
+ break;
+ }
+ } else if ((u > bound && bound > c) || (u < bound && bound < c)) { // u goes beyond the bound
+ u = bound; fu = func(u, data);
+ } else { // u goes the other way around, use golden section extrapolation
+ u = c + gold1 * (c - b); fu = func(u, data);
+ }
+ a = b; b = c; c = u;
+ fa = fb; fb = fc; fc = fu;
+ }
+ if (a > c) u = a, a = c, c = u; // swap
+
+ // now, a<b<c, fa>fb and fb<fc, move on to Brent's algorithm
+ e = d = 0.0;
+ w = v = b; fv = fw = fb;
+ for (iter = 0; iter != max_iter; ++iter) {
+ mid = 0.5 * (a + c);
+ tol2 = 2.0 * (tol1 = tol * fabs(b) + tiny);
+ if (fabs(b - mid) <= (tol2 - 0.5 * (c - a))) {
+ *xmin = b; return fb; // found
+ }
+ if (fabs(e) > tol1) {
+ // related to parabolic interpolation
+ r = (b - w) * (fb - fv);
+ q = (b - v) * (fb - fw);
+ p = (b - v) * q - (b - w) * r;
+ q = 2.0 * (q - r);
+ if (q > 0.0) p = 0.0 - p;
+ else q = 0.0 - q;
+ eold = e; e = d;
+ if (fabs(p) >= fabs(0.5 * q * eold) || p <= q * (a - b) || p >= q * (c - b)) {
+ d = gold2 * (e = (b >= mid ? a - b : c - b));
+ } else {
+ d = p / q; u = b + d; // actual parabolic interpolation happens here
+ if (u - a < tol2 || c - u < tol2)
+ d = (mid > b)? tol1 : 0.0 - tol1;
+ }
+ } else d = gold2 * (e = (b >= mid ? a - b : c - b)); // golden section interpolation
+ u = fabs(d) >= tol1 ? b + d : b + (d > 0.0? tol1 : -tol1);
+ fu = func(u, data);
+ if (fu <= fb) { // u is the minimum point so far
+ if (u >= b) a = b;
+ else c = b;
+ v = w; w = b; b = u; fv = fw; fw = fb; fb = fu;
+ } else { // adjust (a,c) and (u,v,w)
+ if (u < b) a = u;
+ else c = u;
+ if (fu <= fw || w == b) {
+ v = w; w = u;
+ fv = fw; fw = fu;
+ } else if (fu <= fv || v == b || v == w) {
+ v = u; fv = fu;
+ }
+ }
+ }
+ *xmin = b;
+ return fb;
+}
--- /dev/null
+/*
+ Copyright (c) 2008, 2010 by Attractive Chaos <attractor@live.co.uk>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+#ifndef KMIN_H
+#define KMIN_H
+
+#define KMIN_RADIUS 0.5
+#define KMIN_EPS 1e-7
+#define KMIN_MAXCALL 50000
+
+typedef double (*kmin_f)(int, double*, void*);
+typedef double (*kmin1_f)(double, void*);
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ double kmin_hj(kmin_f func, int n, double *x, void *data, double r, double eps, int max_calls);
+ double kmin_brent(kmin1_f func, double a, double b, void *data, double tol, double *xmin);
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include <stdlib.h>
+#include <string.h>
+#include <stdio.h>
+#include <errno.h>
+#include <assert.h>
+#include "prob1.h"
+
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 16384)
+
+#define MC_MAX_EM_ITER 16
+#define MC_EM_EPS 1e-5
+#define MC_DEF_INDEL 0.15
+
+unsigned char seq_nt4_table[256] = {
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4 /*'-'*/, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 0, 4, 1, 4, 4, 4, 2, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 0, 4, 1, 4, 4, 4, 2, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4,
+ 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4, 4
+};
+
+struct __bcf_p1aux_t {
+ int n, M, n1, is_indel;
+ uint8_t *ploidy; // haploid or diploid ONLY
+ double *q2p, *pdg; // pdg -> P(D|g)
+ double *phi, *phi_indel;
+ double *z, *zswap; // aux for afs
+ double *z1, *z2, *phi1, *phi2; // only calculated when n1 is set
+ double **hg; // hypergeometric distribution
+ double *lf; // log factorial
+ double t, t1, t2;
+ double *afs, *afs1; // afs: accumulative AFS; afs1: site posterior distribution
+ const uint8_t *PL; // point to PL
+ int PL_len;
+};
+
+void bcf_p1_indel_prior(bcf_p1aux_t *ma, double x)
+{
+ int i;
+ for (i = 0; i < ma->M; ++i)
+ ma->phi_indel[i] = ma->phi[i] * x;
+ ma->phi_indel[ma->M] = 1. - ma->phi[ma->M] * x;
+}
+
+static void init_prior(int type, double theta, int M, double *phi)
+{
+ int i;
+ if (type == MC_PTYPE_COND2) {
+ for (i = 0; i <= M; ++i)
+ phi[i] = 2. * (i + 1) / (M + 1) / (M + 2);
+ } else if (type == MC_PTYPE_FLAT) {
+ for (i = 0; i <= M; ++i)
+ phi[i] = 1. / (M + 1);
+ } else {
+ double sum;
+ for (i = 0, sum = 0.; i < M; ++i)
+ sum += (phi[i] = theta / (M - i));
+ phi[M] = 1. - sum;
+ }
+}
+
+void bcf_p1_init_prior(bcf_p1aux_t *ma, int type, double theta)
+{
+ init_prior(type, theta, ma->M, ma->phi);
+ bcf_p1_indel_prior(ma, MC_DEF_INDEL);
+}
+
+void bcf_p1_init_subprior(bcf_p1aux_t *ma, int type, double theta)
+{
+ if (ma->n1 <= 0 || ma->n1 >= ma->M) return;
+ init_prior(type, theta, 2*ma->n1, ma->phi1);
+ init_prior(type, theta, 2*(ma->n - ma->n1), ma->phi2);
+}
+
+int bcf_p1_read_prior(bcf_p1aux_t *ma, const char *fn)
+{
+ gzFile fp;
+ kstring_t s;
+ kstream_t *ks;
+ long double sum;
+ int dret, k;
+ memset(&s, 0, sizeof(kstring_t));
+ fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
+ ks = ks_init(fp);
+ memset(ma->phi, 0, sizeof(double) * (ma->M + 1));
+ while (ks_getuntil(ks, '\n', &s, &dret) >= 0) {
+ if (strstr(s.s, "[afs] ") == s.s) {
+ char *p = s.s + 6;
+ for (k = 0; k <= ma->M; ++k) {
+ int x;
+ double y;
+ x = strtol(p, &p, 10);
+ if (x != k && (errno == EINVAL || errno == ERANGE)) return -1;
+ ++p;
+ y = strtod(p, &p);
+ if (y == 0. && (errno == EINVAL || errno == ERANGE)) return -1;
+ ma->phi[ma->M - k] += y;
+ }
+ }
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(s.s);
+ for (sum = 0., k = 0; k <= ma->M; ++k) sum += ma->phi[k];
+ fprintf(pysamerr, "[prior]");
+ for (k = 0; k <= ma->M; ++k) ma->phi[k] /= sum;
+ for (k = 0; k <= ma->M; ++k) fprintf(pysamerr, " %d:%.3lg", k, ma->phi[ma->M - k]);
+ fputc('\n', pysamerr);
+ for (sum = 0., k = 1; k < ma->M; ++k) sum += ma->phi[ma->M - k] * (2.* k * (ma->M - k) / ma->M / (ma->M - 1));
+ fprintf(pysamerr, "[%s] heterozygosity=%lf, ", __func__, (double)sum);
+ for (sum = 0., k = 1; k <= ma->M; ++k) sum += k * ma->phi[ma->M - k] / ma->M;
+ fprintf(pysamerr, "theta=%lf\n", (double)sum);
+ bcf_p1_indel_prior(ma, MC_DEF_INDEL);
+ return 0;
+}
+
+bcf_p1aux_t *bcf_p1_init(int n, uint8_t *ploidy)
+{
+ bcf_p1aux_t *ma;
+ int i;
+ ma = calloc(1, sizeof(bcf_p1aux_t));
+ ma->n1 = -1;
+ ma->n = n; ma->M = 2 * n;
+ if (ploidy) {
+ ma->ploidy = malloc(n);
+ memcpy(ma->ploidy, ploidy, n);
+ for (i = 0, ma->M = 0; i < n; ++i) ma->M += ploidy[i];
+ if (ma->M == 2 * n) {
+ free(ma->ploidy);
+ ma->ploidy = 0;
+ }
+ }
+ ma->q2p = calloc(256, sizeof(double));
+ ma->pdg = calloc(3 * ma->n, sizeof(double));
+ ma->phi = calloc(ma->M + 1, sizeof(double));
+ ma->phi_indel = calloc(ma->M + 1, sizeof(double));
+ ma->phi1 = calloc(ma->M + 1, sizeof(double));
+ ma->phi2 = calloc(ma->M + 1, sizeof(double));
+ ma->z = calloc(ma->M + 1, sizeof(double));
+ ma->zswap = calloc(ma->M + 1, sizeof(double));
+ ma->z1 = calloc(ma->M + 1, sizeof(double)); // actually we do not need this large
+ ma->z2 = calloc(ma->M + 1, sizeof(double));
+ ma->afs = calloc(ma->M + 1, sizeof(double));
+ ma->afs1 = calloc(ma->M + 1, sizeof(double));
+ ma->lf = calloc(ma->M + 1, sizeof(double));
+ for (i = 0; i < 256; ++i)
+ ma->q2p[i] = pow(10., -i / 10.);
+ for (i = 0; i <= ma->M; ++i) ma->lf[i] = lgamma(i + 1);
+ bcf_p1_init_prior(ma, MC_PTYPE_FULL, 1e-3); // the simplest prior
+ return ma;
+}
+
+int bcf_p1_set_n1(bcf_p1aux_t *b, int n1)
+{
+ if (n1 == 0 || n1 >= b->n) return -1;
+ if (b->M != b->n * 2) {
+ fprintf(pysamerr, "[%s] unable to set `n1' when there are haploid samples.\n", __func__);
+ return -1;
+ }
+ b->n1 = n1;
+ return 0;
+}
+
+void bcf_p1_destroy(bcf_p1aux_t *ma)
+{
+ if (ma) {
+ int k;
+ free(ma->lf);
+ if (ma->hg && ma->n1 > 0) {
+ for (k = 0; k <= 2*ma->n1; ++k) free(ma->hg[k]);
+ free(ma->hg);
+ }
+ free(ma->ploidy); free(ma->q2p); free(ma->pdg);
+ free(ma->phi); free(ma->phi_indel); free(ma->phi1); free(ma->phi2);
+ free(ma->z); free(ma->zswap); free(ma->z1); free(ma->z2);
+ free(ma->afs); free(ma->afs1);
+ free(ma);
+ }
+}
+
+static int cal_pdg(const bcf1_t *b, bcf_p1aux_t *ma)
+{
+ int i, j;
+ long *p, tmp;
+ p = alloca(b->n_alleles * sizeof(long));
+ memset(p, 0, sizeof(long) * b->n_alleles);
+ for (j = 0; j < ma->n; ++j) {
+ const uint8_t *pi = ma->PL + j * ma->PL_len;
+ double *pdg = ma->pdg + j * 3;
+ pdg[0] = ma->q2p[pi[2]]; pdg[1] = ma->q2p[pi[1]]; pdg[2] = ma->q2p[pi[0]];
+ for (i = 0; i < b->n_alleles; ++i)
+ p[i] += (int)pi[(i+1)*(i+2)/2-1];
+ }
+ for (i = 0; i < b->n_alleles; ++i) p[i] = p[i]<<4 | i;
+ for (i = 1; i < b->n_alleles; ++i) // insertion sort
+ for (j = i; j > 0 && p[j] < p[j-1]; --j)
+ tmp = p[j], p[j] = p[j-1], p[j-1] = tmp;
+ for (i = b->n_alleles - 1; i >= 0; --i)
+ if ((p[i]&0xf) == 0) break;
+ return i;
+}
+
+int bcf_p1_call_gt(const bcf_p1aux_t *ma, double f0, int k)
+{
+ double sum, g[3];
+ double max, f3[3], *pdg = ma->pdg + k * 3;
+ int q, i, max_i, ploidy;
+ ploidy = ma->ploidy? ma->ploidy[k] : 2;
+ if (ploidy == 2) {
+ f3[0] = (1.-f0)*(1.-f0); f3[1] = 2.*f0*(1.-f0); f3[2] = f0*f0;
+ } else {
+ f3[0] = 1. - f0; f3[1] = 0; f3[2] = f0;
+ }
+ for (i = 0, sum = 0.; i < 3; ++i)
+ sum += (g[i] = pdg[i] * f3[i]);
+ for (i = 0, max = -1., max_i = 0; i < 3; ++i) {
+ g[i] /= sum;
+ if (g[i] > max) max = g[i], max_i = i;
+ }
+ max = 1. - max;
+ if (max < 1e-308) max = 1e-308;
+ q = (int)(-4.343 * log(max) + .499);
+ if (q > 99) q = 99;
+ return q<<2|max_i;
+}
+
+#define TINY 1e-20
+
+static void mc_cal_y_core(bcf_p1aux_t *ma, int beg)
+{
+ double *z[2], *tmp, *pdg;
+ int _j, last_min, last_max;
+ assert(beg == 0 || ma->M == ma->n*2);
+ z[0] = ma->z;
+ z[1] = ma->zswap;
+ pdg = ma->pdg;
+ memset(z[0], 0, sizeof(double) * (ma->M + 1));
+ memset(z[1], 0, sizeof(double) * (ma->M + 1));
+ z[0][0] = 1.;
+ last_min = last_max = 0;
+ ma->t = 0.;
+ if (ma->M == ma->n * 2) {
+ int M = 0;
+ for (_j = beg; _j < ma->n; ++_j) {
+ int k, j = _j - beg, _min = last_min, _max = last_max, M0;
+ double p[3], sum;
+ M0 = M; M += 2;
+ pdg = ma->pdg + _j * 3;
+ p[0] = pdg[0]; p[1] = 2. * pdg[1]; p[2] = pdg[2];
+ for (; _min < _max && z[0][_min] < TINY; ++_min) z[0][_min] = z[1][_min] = 0.;
+ for (; _max > _min && z[0][_max] < TINY; --_max) z[0][_max] = z[1][_max] = 0.;
+ _max += 2;
+ if (_min == 0) k = 0, z[1][k] = (M0-k+1) * (M0-k+2) * p[0] * z[0][k];
+ if (_min <= 1) k = 1, z[1][k] = (M0-k+1) * (M0-k+2) * p[0] * z[0][k] + k*(M0-k+2) * p[1] * z[0][k-1];
+ for (k = _min < 2? 2 : _min; k <= _max; ++k)
+ z[1][k] = (M0-k+1)*(M0-k+2) * p[0] * z[0][k] + k*(M0-k+2) * p[1] * z[0][k-1] + k*(k-1)* p[2] * z[0][k-2];
+ for (k = _min, sum = 0.; k <= _max; ++k) sum += z[1][k];
+ ma->t += log(sum / (M * (M - 1.)));
+ for (k = _min; k <= _max; ++k) z[1][k] /= sum;
+ if (_min >= 1) z[1][_min-1] = 0.;
+ if (_min >= 2) z[1][_min-2] = 0.;
+ if (j < ma->n - 1) z[1][_max+1] = z[1][_max+2] = 0.;
+ if (_j == ma->n1 - 1) { // set pop1; ma->n1==-1 when unset
+ ma->t1 = ma->t;
+ memcpy(ma->z1, z[1], sizeof(double) * (ma->n1 * 2 + 1));
+ }
+ tmp = z[0]; z[0] = z[1]; z[1] = tmp;
+ last_min = _min; last_max = _max;
+ }
+ //for (_j = 0; _j < last_min; ++_j) z[0][_j] = 0.; // TODO: are these necessary?
+ //for (_j = last_max + 1; _j < ma->M; ++_j) z[0][_j] = 0.;
+ } else { // this block is very similar to the block above; these two might be merged in future
+ int j, M = 0;
+ for (j = 0; j < ma->n; ++j) {
+ int k, M0, _min = last_min, _max = last_max;
+ double p[3], sum;
+ pdg = ma->pdg + j * 3;
+ for (; _min < _max && z[0][_min] < TINY; ++_min) z[0][_min] = z[1][_min] = 0.;
+ for (; _max > _min && z[0][_max] < TINY; --_max) z[0][_max] = z[1][_max] = 0.;
+ M0 = M;
+ M += ma->ploidy[j];
+ if (ma->ploidy[j] == 1) {
+ p[0] = pdg[0]; p[1] = pdg[2];
+ _max++;
+ if (_min == 0) k = 0, z[1][k] = (M0+1-k) * p[0] * z[0][k];
+ for (k = _min < 1? 1 : _min; k <= _max; ++k)
+ z[1][k] = (M0+1-k) * p[0] * z[0][k] + k * p[1] * z[0][k-1];
+ for (k = _min, sum = 0.; k <= _max; ++k) sum += z[1][k];
+ ma->t += log(sum / M);
+ for (k = _min; k <= _max; ++k) z[1][k] /= sum;
+ if (_min >= 1) z[1][_min-1] = 0.;
+ if (j < ma->n - 1) z[1][_max+1] = 0.;
+ } else if (ma->ploidy[j] == 2) {
+ p[0] = pdg[0]; p[1] = 2 * pdg[1]; p[2] = pdg[2];
+ _max += 2;
+ if (_min == 0) k = 0, z[1][k] = (M0-k+1) * (M0-k+2) * p[0] * z[0][k];
+ if (_min <= 1) k = 1, z[1][k] = (M0-k+1) * (M0-k+2) * p[0] * z[0][k] + k*(M0-k+2) * p[1] * z[0][k-1];
+ for (k = _min < 2? 2 : _min; k <= _max; ++k)
+ z[1][k] = (M0-k+1)*(M0-k+2) * p[0] * z[0][k] + k*(M0-k+2) * p[1] * z[0][k-1] + k*(k-1)* p[2] * z[0][k-2];
+ for (k = _min, sum = 0.; k <= _max; ++k) sum += z[1][k];
+ ma->t += log(sum / (M * (M - 1.)));
+ for (k = _min; k <= _max; ++k) z[1][k] /= sum;
+ if (_min >= 1) z[1][_min-1] = 0.;
+ if (_min >= 2) z[1][_min-2] = 0.;
+ if (j < ma->n - 1) z[1][_max+1] = z[1][_max+2] = 0.;
+ }
+ tmp = z[0]; z[0] = z[1]; z[1] = tmp;
+ last_min = _min; last_max = _max;
+ }
+ }
+ if (z[0] != ma->z) memcpy(ma->z, z[0], sizeof(double) * (ma->M + 1));
+}
+
+static void mc_cal_y(bcf_p1aux_t *ma)
+{
+ if (ma->n1 > 0 && ma->n1 < ma->n && ma->M == ma->n * 2) { // NB: ma->n1 is ineffective when there are haploid samples
+ int k;
+ long double x;
+ memset(ma->z1, 0, sizeof(double) * (2 * ma->n1 + 1));
+ memset(ma->z2, 0, sizeof(double) * (2 * (ma->n - ma->n1) + 1));
+ ma->t1 = ma->t2 = 0.;
+ mc_cal_y_core(ma, ma->n1);
+ ma->t2 = ma->t;
+ memcpy(ma->z2, ma->z, sizeof(double) * (2 * (ma->n - ma->n1) + 1));
+ mc_cal_y_core(ma, 0);
+ // rescale z
+ x = expl(ma->t - (ma->t1 + ma->t2));
+ for (k = 0; k <= ma->M; ++k) ma->z[k] *= x;
+ } else mc_cal_y_core(ma, 0);
+}
+
+#define CONTRAST_TINY 1e-30
+
+extern double kf_gammaq(double s, double z); // incomplete gamma function for chi^2 test
+
+static inline double chi2_test(int a, int b, int c, int d)
+{
+ double x, z;
+ x = (double)(a+b) * (c+d) * (b+d) * (a+c);
+ if (x == 0.) return 1;
+ z = a * d - b * c;
+ return kf_gammaq(.5, .5 * z * z * (a+b+c+d) / x);
+}
+
+// chi2=(a+b+c+d)(ad-bc)^2/[(a+b)(c+d)(a+c)(b+d)]
+static inline double contrast2_aux(const bcf_p1aux_t *p1, double sum, int k1, int k2, double x[3])
+{
+ double p = p1->phi[k1+k2] * p1->z1[k1] * p1->z2[k2] / sum * p1->hg[k1][k2];
+ int n1 = p1->n1, n2 = p1->n - p1->n1;
+ if (p < CONTRAST_TINY) return -1;
+ if (.5*k1/n1 < .5*k2/n2) x[1] += p;
+ else if (.5*k1/n1 > .5*k2/n2) x[2] += p;
+ else x[0] += p;
+ return p * chi2_test(k1, k2, (n1<<1) - k1, (n2<<1) - k2);
+}
+
+static double contrast2(bcf_p1aux_t *p1, double ret[3])
+{
+ int k, k1, k2, k10, k20, n1, n2;
+ double sum;
+ // get n1 and n2
+ n1 = p1->n1; n2 = p1->n - p1->n1;
+ if (n1 <= 0 || n2 <= 0) return 0.;
+ if (p1->hg == 0) { // initialize the hypergeometric distribution
+ /* NB: the hg matrix may take a lot of memory when there are many samples. There is a way
+ to avoid precomputing this matrix, but it is slower and quite intricate. The following
+ computation in this block can be accelerated with a similar strategy, but perhaps this
+ is not a serious concern for now. */
+ double tmp = lgamma(2*(n1+n2)+1) - (lgamma(2*n1+1) + lgamma(2*n2+1));
+ p1->hg = calloc(2*n1+1, sizeof(void*));
+ for (k1 = 0; k1 <= 2*n1; ++k1) {
+ p1->hg[k1] = calloc(2*n2+1, sizeof(double));
+ for (k2 = 0; k2 <= 2*n2; ++k2)
+ p1->hg[k1][k2] = exp(lgamma(k1+k2+1) + lgamma(p1->M-k1-k2+1) - (lgamma(k1+1) + lgamma(k2+1) + lgamma(2*n1-k1+1) + lgamma(2*n2-k2+1) + tmp));
+ }
+ }
+ { // compute
+ long double suml = 0;
+ for (k = 0; k <= p1->M; ++k) suml += p1->phi[k] * p1->z[k];
+ sum = suml;
+ }
+ { // get the max k1 and k2
+ double max;
+ int max_k;
+ for (k = 0, max = 0, max_k = -1; k <= 2*n1; ++k) {
+ double x = p1->phi1[k] * p1->z1[k];
+ if (x > max) max = x, max_k = k;
+ }
+ k10 = max_k;
+ for (k = 0, max = 0, max_k = -1; k <= 2*n2; ++k) {
+ double x = p1->phi2[k] * p1->z2[k];
+ if (x > max) max = x, max_k = k;
+ }
+ k20 = max_k;
+ }
+ { // We can do the following with one nested loop, but that is an O(N^2) thing. The following code block is much faster for large N.
+ double x[3], y;
+ long double z = 0., L[2];
+ x[0] = x[1] = x[2] = 0; L[0] = L[1] = 0;
+ for (k1 = k10; k1 >= 0; --k1) {
+ for (k2 = k20; k2 >= 0; --k2) {
+ if ((y = contrast2_aux(p1, sum, k1, k2, x)) < 0) break;
+ else z += y;
+ }
+ for (k2 = k20 + 1; k2 <= 2*n2; ++k2) {
+ if ((y = contrast2_aux(p1, sum, k1, k2, x)) < 0) break;
+ else z += y;
+ }
+ }
+ ret[0] = x[0]; ret[1] = x[1]; ret[2] = x[2];
+ x[0] = x[1] = x[2] = 0;
+ for (k1 = k10 + 1; k1 <= 2*n1; ++k1) {
+ for (k2 = k20; k2 >= 0; --k2) {
+ if ((y = contrast2_aux(p1, sum, k1, k2, x)) < 0) break;
+ else z += y;
+ }
+ for (k2 = k20 + 1; k2 <= 2*n2; ++k2) {
+ if ((y = contrast2_aux(p1, sum, k1, k2, x)) < 0) break;
+ else z += y;
+ }
+ }
+ ret[0] += x[0]; ret[1] += x[1]; ret[2] += x[2];
+ if (ret[0] + ret[1] + ret[2] < 0.95) { // in case of bad things happened
+ ret[0] = ret[1] = ret[2] = 0; L[0] = L[1] = 0;
+ for (k1 = 0, z = 0.; k1 <= 2*n1; ++k1)
+ for (k2 = 0; k2 <= 2*n2; ++k2)
+ if ((y = contrast2_aux(p1, sum, k1, k2, ret)) >= 0) z += y;
+ if (ret[0] + ret[1] + ret[2] < 0.95) // It seems that this may be caused by floating point errors. I do not really understand why...
+ z = 1.0, ret[0] = ret[1] = ret[2] = 1./3;
+ }
+ return (double)z;
+ }
+}
+
+static double mc_cal_afs(bcf_p1aux_t *ma, double *p_ref_folded, double *p_var_folded)
+{
+ int k;
+ long double sum = 0., sum2;
+ double *phi = ma->is_indel? ma->phi_indel : ma->phi;
+ memset(ma->afs1, 0, sizeof(double) * (ma->M + 1));
+ mc_cal_y(ma);
+ // compute AFS
+ for (k = 0, sum = 0.; k <= ma->M; ++k)
+ sum += (long double)phi[k] * ma->z[k];
+ for (k = 0; k <= ma->M; ++k) {
+ ma->afs1[k] = phi[k] * ma->z[k] / sum;
+ if (isnan(ma->afs1[k]) || isinf(ma->afs1[k])) return -1.;
+ }
+ // compute folded variant probability
+ for (k = 0, sum = 0.; k <= ma->M; ++k)
+ sum += (long double)(phi[k] + phi[ma->M - k]) / 2. * ma->z[k];
+ for (k = 1, sum2 = 0.; k < ma->M; ++k)
+ sum2 += (long double)(phi[k] + phi[ma->M - k]) / 2. * ma->z[k];
+ *p_var_folded = sum2 / sum;
+ *p_ref_folded = (phi[k] + phi[ma->M - k]) / 2. * (ma->z[ma->M] + ma->z[0]) / sum;
+ // the expected frequency
+ for (k = 0, sum = 0.; k <= ma->M; ++k) {
+ ma->afs[k] += ma->afs1[k];
+ sum += k * ma->afs1[k];
+ }
+ return sum / ma->M;
+}
+
+int bcf_p1_cal(const bcf1_t *b, int do_contrast, bcf_p1aux_t *ma, bcf_p1rst_t *rst)
+{
+ int i, k;
+ long double sum = 0.;
+ ma->is_indel = bcf_is_indel(b);
+ rst->perm_rank = -1;
+ // set PL and PL_len
+ for (i = 0; i < b->n_gi; ++i) {
+ if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ ma->PL = (uint8_t*)b->gi[i].data;
+ ma->PL_len = b->gi[i].len;
+ break;
+ }
+ }
+ if (i == b->n_gi) return -1; // no PL
+ if (b->n_alleles < 2) return -1; // FIXME: find a better solution
+ //
+ rst->rank0 = cal_pdg(b, ma);
+ rst->f_exp = mc_cal_afs(ma, &rst->p_ref_folded, &rst->p_var_folded);
+ rst->p_ref = ma->afs1[ma->M];
+ for (k = 0, sum = 0.; k < ma->M; ++k)
+ sum += ma->afs1[k];
+ rst->p_var = (double)sum;
+ // calculate f_flat and f_em
+ for (k = 0, sum = 0.; k <= ma->M; ++k)
+ sum += (long double)ma->z[k];
+ rst->f_flat = 0.;
+ for (k = 0; k <= ma->M; ++k) {
+ double p = ma->z[k] / sum;
+ rst->f_flat += k * p;
+ }
+ rst->f_flat /= ma->M;
+ { // estimate equal-tail credible interval (95% level)
+ int l, h;
+ double p;
+ for (i = 0, p = 0.; i < ma->M; ++i)
+ if (p + ma->afs1[i] > 0.025) break;
+ else p += ma->afs1[i];
+ l = i;
+ for (i = ma->M-1, p = 0.; i >= 0; --i)
+ if (p + ma->afs1[i] > 0.025) break;
+ else p += ma->afs1[i];
+ h = i;
+ rst->cil = (double)(ma->M - h) / ma->M; rst->cih = (double)(ma->M - l) / ma->M;
+ }
+ rst->cmp[0] = rst->cmp[1] = rst->cmp[2] = rst->p_chi2 = -1.0;
+ if (do_contrast && rst->p_var > 0.5) // skip contrast2() if the locus is a strong non-variant
+ rst->p_chi2 = contrast2(ma, rst->cmp);
+ return 0;
+}
+
+void bcf_p1_dump_afs(bcf_p1aux_t *ma)
+{
+ int k;
+ fprintf(pysamerr, "[afs]");
+ for (k = 0; k <= ma->M; ++k)
+ fprintf(pysamerr, " %d:%.3lf", k, ma->afs[ma->M - k]);
+ fprintf(pysamerr, "\n");
+ memset(ma->afs, 0, sizeof(double) * (ma->M + 1));
+}
--- /dev/null
+#ifndef BCF_PROB1_H
+#define BCF_PROB1_H
+
+#include "bcf.h"
+
+struct __bcf_p1aux_t;
+typedef struct __bcf_p1aux_t bcf_p1aux_t;
+
+typedef struct {
+ int rank0, perm_rank; // NB: perm_rank is always set to -1 by bcf_p1_cal()
+ double f_exp, f_flat, p_ref_folded, p_ref, p_var_folded, p_var;
+ double cil, cih;
+ double cmp[3], p_chi2; // used by contrast2()
+} bcf_p1rst_t;
+
+#define MC_PTYPE_FULL 1
+#define MC_PTYPE_COND2 2
+#define MC_PTYPE_FLAT 3
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ bcf_p1aux_t *bcf_p1_init(int n, uint8_t *ploidy);
+ void bcf_p1_init_prior(bcf_p1aux_t *ma, int type, double theta);
+ void bcf_p1_init_subprior(bcf_p1aux_t *ma, int type, double theta);
+ void bcf_p1_destroy(bcf_p1aux_t *ma);
+ int bcf_p1_cal(const bcf1_t *b, int do_contrast, bcf_p1aux_t *ma, bcf_p1rst_t *rst);
+ int bcf_p1_call_gt(const bcf_p1aux_t *ma, double f0, int k);
+ void bcf_p1_dump_afs(bcf_p1aux_t *ma);
+ int bcf_p1_read_prior(bcf_p1aux_t *ma, const char *fn);
+ int bcf_p1_set_n1(bcf_p1aux_t *b, int n1);
+ void bcf_p1_set_folded(bcf_p1aux_t *p1a); // only effective when set_n1() is not called
+
+ int bcf_em1(const bcf1_t *b, int n1, int flag, double x[9]);
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif
--- /dev/null
+#include "pysam.h"
+
+#include <zlib.h>
+#include <stdlib.h>
+#include <stdio.h>
+#include <string.h>
+#include "bcf.h"
+#include "kstring.h"
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 4096)
+
+typedef struct {
+ gzFile fp;
+ FILE *fpout;
+ kstream_t *ks;
+ void *refhash;
+ kstring_t line;
+ int max_ref;
+} vcf_t;
+
+bcf_hdr_t *vcf_hdr_read(bcf_t *bp)
+{
+ kstring_t meta, smpl;
+ int dret;
+ vcf_t *v;
+ bcf_hdr_t *h;
+ if (!bp->is_vcf) return bcf_hdr_read(bp);
+ h = calloc(1, sizeof(bcf_hdr_t));
+ v = (vcf_t*)bp->v;
+ v->line.l = 0;
+ memset(&meta, 0, sizeof(kstring_t));
+ memset(&smpl, 0, sizeof(kstring_t));
+ while (ks_getuntil(v->ks, '\n', &v->line, &dret) >= 0) {
+ if (v->line.l < 2) continue;
+ if (v->line.s[0] != '#') return 0; // no sample line
+ if (v->line.s[0] == '#' && v->line.s[1] == '#') {
+ kputsn(v->line.s, v->line.l, &meta); kputc('\n', &meta);
+ } else if (v->line.s[0] == '#') {
+ int k;
+ ks_tokaux_t aux;
+ char *p;
+ for (p = kstrtok(v->line.s, "\t\n", &aux), k = 0; p; p = kstrtok(0, 0, &aux), ++k) {
+ if (k >= 9) {
+ kputsn(p, aux.p - p, &smpl);
+ kputc('\0', &smpl);
+ }
+ }
+ break;
+ }
+ }
+ kputc('\0', &meta);
+ h->name = 0;
+ h->sname = smpl.s; h->l_smpl = smpl.l;
+ h->txt = meta.s; h->l_txt = meta.l;
+ bcf_hdr_sync(h);
+ return h;
+}
+
+bcf_t *vcf_open(const char *fn, const char *mode)
+{
+ bcf_t *bp;
+ vcf_t *v;
+ if (strchr(mode, 'b')) return bcf_open(fn, mode);
+ bp = calloc(1, sizeof(bcf_t));
+ v = calloc(1, sizeof(vcf_t));
+ bp->is_vcf = 1;
+ bp->v = v;
+ v->refhash = bcf_str2id_init();
+ if (strchr(mode, 'r')) {
+ v->fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
+ v->ks = ks_init(v->fp);
+ } else if (strchr(mode, 'w'))
+ v->fpout = strcmp(fn, "-")? fopen(fn, "w") : stdout;
+ return bp;
+}
+
+int vcf_dictread(bcf_t *bp, bcf_hdr_t *h, const char *fn)
+{
+ vcf_t *v;
+ gzFile fp;
+ kstream_t *ks;
+ kstring_t s, rn;
+ int dret;
+ if (bp == 0) return -1;
+ if (!bp->is_vcf) return 0;
+ s.l = s.m = 0; s.s = 0;
+ rn.m = rn.l = h->l_nm; rn.s = h->name;
+ v = (vcf_t*)bp->v;
+ fp = gzopen(fn, "r");
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, 0, &s, &dret) >= 0) {
+ bcf_str2id_add(v->refhash, strdup(s.s));
+ kputs(s.s, &rn); kputc('\0', &rn);
+ if (dret != '\n') ks_getuntil(ks, '\n', &s, &dret);
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ h->l_nm = rn.l; h->name = rn.s;
+ bcf_hdr_sync(h);
+ free(s.s);
+ return 0;
+}
+
+int vcf_close(bcf_t *bp)
+{
+ vcf_t *v;
+ if (bp == 0) return -1;
+ if (!bp->is_vcf) return bcf_close(bp);
+ v = (vcf_t*)bp->v;
+ if (v->fp) {
+ ks_destroy(v->ks);
+ gzclose(v->fp);
+ }
+ if (v->fpout) fclose(v->fpout);
+ free(v->line.s);
+ bcf_str2id_thorough_destroy(v->refhash);
+ free(v);
+ free(bp);
+ return 0;
+}
+
+int vcf_hdr_write(bcf_t *bp, const bcf_hdr_t *h)
+{
+ vcf_t *v = (vcf_t*)bp->v;
+ int i, has_ver = 0;
+ if (!bp->is_vcf) return bcf_hdr_write(bp, h);
+ if (h->l_txt > 0) {
+ if (strstr(h->txt, "##fileformat=")) has_ver = 1;
+ if (has_ver == 0) fprintf(v->fpout, "##fileformat=VCFv4.1\n");
+ fwrite(h->txt, 1, h->l_txt - 1, v->fpout);
+ }
+ if (h->l_txt == 0) fprintf(v->fpout, "##fileformat=VCFv4.1\n");
+ fprintf(v->fpout, "#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT");
+ for (i = 0; i < h->n_smpl; ++i)
+ fprintf(v->fpout, "\t%s", h->sns[i]);
+ fputc('\n', v->fpout);
+ return 0;
+}
+
+int vcf_write(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b)
+{
+ vcf_t *v = (vcf_t*)bp->v;
+ extern void bcf_fmt_core(const bcf_hdr_t *h, bcf1_t *b, kstring_t *s);
+ if (!bp->is_vcf) return bcf_write(bp, h, b);
+ bcf_fmt_core(h, b, &v->line);
+ fwrite(v->line.s, 1, v->line.l, v->fpout);
+ fputc('\n', v->fpout);
+ return v->line.l + 1;
+}
+
+int vcf_read(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b)
+{
+ int dret, k, i, sync = 0;
+ vcf_t *v = (vcf_t*)bp->v;
+ char *p, *q;
+ kstring_t str, rn;
+ ks_tokaux_t aux, a2;
+ if (!bp->is_vcf) return bcf_read(bp, h, b);
+ v->line.l = 0;
+ str.l = 0; str.m = b->m_str; str.s = b->str;
+ rn.l = rn.m = h->l_nm; rn.s = h->name;
+ if (ks_getuntil(v->ks, '\n', &v->line, &dret) < 0) return -1;
+ b->n_smpl = h->n_smpl;
+ for (p = kstrtok(v->line.s, "\t", &aux), k = 0; p; p = kstrtok(0, 0, &aux), ++k) {
+ *(char*)aux.p = 0;
+ if (k == 0) { // ref
+ int tid = bcf_str2id(v->refhash, p);
+ if (tid < 0) {
+ tid = bcf_str2id_add(v->refhash, strdup(p));
+ kputs(p, &rn); kputc('\0', &rn);
+ sync = 1;
+ }
+ b->tid = tid;
+ } else if (k == 1) { // pos
+ b->pos = atoi(p) - 1;
+ } else if (k == 5) { // qual
+ b->qual = (p[0] >= '0' && p[0] <= '9')? atof(p) : 0;
+ } else if (k <= 8) { // variable length strings
+ kputs(p, &str); kputc('\0', &str);
+ b->l_str = str.l; b->m_str = str.m; b->str = str.s;
+ if (k == 8) bcf_sync(b);
+ } else { // k > 9
+ if (strncmp(p, "./.", 3) == 0) {
+ for (i = 0; i < b->n_gi; ++i) {
+ if (b->gi[i].fmt == bcf_str2int("GT", 2)) {
+ ((uint8_t*)b->gi[i].data)[k-9] = 1<<7;
+ } else if (b->gi[i].fmt == bcf_str2int("GQ", 2)) {
+ ((uint8_t*)b->gi[i].data)[k-9] = 0;
+ } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
+ ((int32_t*)b->gi[i].data)[k-9] = 0;
+ } else if (b->gi[i].fmt == bcf_str2int("DP", 2)) {
+ ((uint16_t*)b->gi[i].data)[k-9] = 0;
+ } else if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ int y = b->n_alleles * (b->n_alleles + 1) / 2;
+ memset((uint8_t*)b->gi[i].data + (k - 9) * y, 0, y);
+ } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
+ int y = b->n_alleles * (b->n_alleles + 1) / 2;
+ memset((float*)b->gi[i].data + (k - 9) * y, 0, y * 4);
+ }
+ }
+ goto endblock;
+ }
+ for (q = kstrtok(p, ":", &a2), i = 0; q && i < b->n_gi; q = kstrtok(0, 0, &a2), ++i) {
+ if (b->gi[i].fmt == bcf_str2int("GT", 2)) {
+ ((uint8_t*)b->gi[i].data)[k-9] = (q[0] - '0')<<3 | (q[2] - '0') | (q[1] == '/'? 0 : 1) << 6;
+ } else if (b->gi[i].fmt == bcf_str2int("GQ", 2)) {
+ double _x = strtod(q, &q);
+ int x = (int)(_x + .499);
+ if (x > 255) x = 255;
+ ((uint8_t*)b->gi[i].data)[k-9] = x;
+ } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
+ int x = strtol(q, &q, 10);
+ if (x > 0xffff) x = 0xffff;
+ ((uint32_t*)b->gi[i].data)[k-9] = x;
+ } else if (b->gi[i].fmt == bcf_str2int("DP", 2)) {
+ int x = strtol(q, &q, 10);
+ if (x > 0xffff) x = 0xffff;
+ ((uint16_t*)b->gi[i].data)[k-9] = x;
+ } else if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
+ int x, y, j;
+ uint8_t *data = (uint8_t*)b->gi[i].data;
+ y = b->n_alleles * (b->n_alleles + 1) / 2;
+ for (j = 0; j < y; ++j) {
+ x = strtol(q, &q, 10);
+ if (x > 255) x = 255;
+ data[(k-9) * y + j] = x;
+ ++q;
+ }
+ } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
+ int j, y;
+ float x, *data = (float*)b->gi[i].data;
+ y = b->n_alleles * (b->n_alleles + 1) / 2;
+ for (j = 0; j < y; ++j) {
+ x = strtod(q, &q);
+ data[(k-9) * y + j] = x > 0? -x/10. : x;
+ ++q;
+ }
+ }
+ }
+ endblock: i = i;
+ }
+ }
+ h->l_nm = rn.l; h->name = rn.s;
+ if (sync) bcf_hdr_sync(h);
+ return v->line.l + 1;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <stdint.h>
+#include <string.h>
+#include <stdio.h>
+#include <zlib.h>
+
+#include "ksort.h"
+KSORT_INIT_GENERIC(uint64_t)
+
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 8192)
+
+typedef struct {
+ int n, m;
+ uint64_t *a;
+ int *idx;
+} bed_reglist_t;
+
+#include "khash.h"
+KHASH_MAP_INIT_STR(reg, bed_reglist_t)
+
+#define LIDX_SHIFT 13
+
+typedef kh_reg_t reghash_t;
+
+int *bed_index_core(int n, uint64_t *a, int *n_idx)
+{
+ int i, j, m, *idx;
+ m = *n_idx = 0; idx = 0;
+ for (i = 0; i < n; ++i) {
+ int beg, end;
+ beg = a[i]>>32 >> LIDX_SHIFT; end = ((uint32_t)a[i]) >> LIDX_SHIFT;
+ if (m < end + 1) {
+ int oldm = m;
+ m = end + 1;
+ kroundup32(m);
+ idx = realloc(idx, m * sizeof(int));
+ for (j = oldm; j < m; ++j) idx[j] = -1;
+ }
+ if (beg == end) {
+ if (idx[beg] < 0) idx[beg] = i;
+ } else {
+ for (j = beg; j <= end; ++j)
+ if (idx[j] < 0) idx[j] = i;
+ }
+ *n_idx = end + 1;
+ }
+ return idx;
+}
+
+void bed_index(void *_h)
+{
+ reghash_t *h = (reghash_t*)_h;
+ khint_t k;
+ for (k = 0; k < kh_end(h); ++k) {
+ if (kh_exist(h, k)) {
+ bed_reglist_t *p = &kh_val(h, k);
+ if (p->idx) free(p->idx);
+ ks_introsort(uint64_t, p->n, p->a);
+ p->idx = bed_index_core(p->n, p->a, &p->m);
+ }
+ }
+}
+
+int bed_overlap_core(const bed_reglist_t *p, int beg, int end)
+{
+ int i, min_off;
+ if (p->n == 0) return 0;
+ min_off = (beg>>LIDX_SHIFT >= p->n)? p->idx[p->n-1] : p->idx[beg>>LIDX_SHIFT];
+ if (min_off < 0) { // TODO: this block can be improved, but speed should not matter too much here
+ int n = beg>>LIDX_SHIFT;
+ if (n > p->n) n = p->n;
+ for (i = n - 1; i >= 0; --i)
+ if (p->idx[i] >= 0) break;
+ min_off = i >= 0? p->idx[i] : 0;
+ }
+ for (i = min_off; i < p->n; ++i) {
+ if ((int)(p->a[i]>>32) >= end) break; // out of range; no need to proceed
+ if ((int32_t)p->a[i] > beg && (int32_t)(p->a[i]>>32) < end)
+ return 1; // find the overlap; return
+ }
+ return 0;
+}
+
+int bed_overlap(const void *_h, const char *chr, int beg, int end)
+{
+ const reghash_t *h = (const reghash_t*)_h;
+ khint_t k;
+ if (!h) return 0;
+ k = kh_get(reg, h, chr);
+ if (k == kh_end(h)) return 0;
+ return bed_overlap_core(&kh_val(h, k), beg, end);
+}
+
+void *bed_read(const char *fn)
+{
+ reghash_t *h = kh_init(reg);
+ gzFile fp;
+ kstream_t *ks;
+ int dret;
+ kstring_t *str;
+ // read the list
+ fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
+ if (fp == 0) return 0;
+ str = calloc(1, sizeof(kstring_t));
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, 0, str, &dret) >= 0) { // read the chr name
+ int beg = -1, end = -1;
+ bed_reglist_t *p;
+ khint_t k = kh_get(reg, h, str->s);
+ if (k == kh_end(h)) { // absent from the hash table
+ int ret;
+ char *s = strdup(str->s);
+ k = kh_put(reg, h, s, &ret);
+ memset(&kh_val(h, k), 0, sizeof(bed_reglist_t));
+ }
+ p = &kh_val(h, k);
+ if (dret != '\n') { // if the lines has other characters
+ if (ks_getuntil(ks, 0, str, &dret) > 0 && isdigit(str->s[0])) {
+ beg = atoi(str->s); // begin
+ if (dret != '\n') {
+ if (ks_getuntil(ks, 0, str, &dret) > 0 && isdigit(str->s[0]))
+ end = atoi(str->s); // end
+ }
+ }
+ }
+ if (dret != '\n') while ((dret = ks_getc(ks)) > 0 && dret != '\n'); // skip the rest of the line
+ if (end < 0 && beg > 0) end = beg, beg = beg - 1; // if there is only one column
+ if (beg >= 0 && end > beg) {
+ if (p->n == p->m) {
+ p->m = p->m? p->m<<1 : 4;
+ p->a = realloc(p->a, p->m * 8);
+ }
+ p->a[p->n++] = (uint64_t)beg<<32 | end;
+ }
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(str->s); free(str);
+ bed_index(h);
+ return h;
+}
+
+void bed_destroy(void *_h)
+{
+ reghash_t *h = (reghash_t*)_h;
+ khint_t k;
+ for (k = 0; k < kh_end(h); ++k) {
+ if (kh_exist(h, k)) {
+ free(kh_val(h, k).a);
+ free(kh_val(h, k).idx);
+ free((char*)kh_key(h, k));
+ }
+ }
+ kh_destroy(reg, h);
+}
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
-
- Permission is hereby granted, free of charge, to any person obtaining a copy
- of this software and associated documentation files (the "Software"), to deal
- in the Software without restriction, including without limitation the rights
- to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
- copies of the Software, and to permit persons to whom the Software is
- furnished to do so, subject to the following conditions:
-
- The above copyright notice and this permission notice shall be included in
- all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
- IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
- FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
- AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
- LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
- OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
- THE SOFTWARE.
-*/
-
-/*
- 2009-06-29 by lh3: cache recent uncompressed blocks.
- 2009-06-25 by lh3: optionally use my knetfile library to access file on a FTP.
- 2009-06-12 by lh3: support a mode string like "wu" where 'u' for uncompressed output */
-
-#include <stdio.h>
-#include <stdlib.h>
-#include <string.h>
-#include <unistd.h>
-#include <fcntl.h>
-#include <sys/types.h>
-#include <sys/stat.h>
-#include "bgzf.h"
-
-#include "khash.h"
-typedef struct {
- int size;
- uint8_t *block;
- int64_t end_offset;
-} cache_t;
-KHASH_MAP_INIT_INT64(cache, cache_t)
-
-#if defined(_WIN32) || defined(_MSC_VER)
-#define ftello(fp) ftell(fp)
-#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
-#else
-extern off_t ftello(FILE *stream);
-extern int fseeko(FILE *stream, off_t offset, int whence);
-#endif
-
-typedef int8_t bgzf_byte_t;
-
-static const int DEFAULT_BLOCK_SIZE = 64 * 1024;
-static const int MAX_BLOCK_SIZE = 64 * 1024;
-
-static const int BLOCK_HEADER_LENGTH = 18;
-static const int BLOCK_FOOTER_LENGTH = 8;
-
-static const int GZIP_ID1 = 31;
-static const int GZIP_ID2 = 139;
-static const int CM_DEFLATE = 8;
-static const int FLG_FEXTRA = 4;
-static const int OS_UNKNOWN = 255;
-static const int BGZF_ID1 = 66; // 'B'
-static const int BGZF_ID2 = 67; // 'C'
-static const int BGZF_LEN = 2;
-static const int BGZF_XLEN = 6; // BGZF_LEN+4
-
-static const int GZIP_WINDOW_BITS = -15; // no zlib header
-static const int Z_DEFAULT_MEM_LEVEL = 8;
-
-
-inline
-void
-packInt16(uint8_t* buffer, uint16_t value)
-{
- buffer[0] = value;
- buffer[1] = value >> 8;
-}
-
-inline
-int
-unpackInt16(const uint8_t* buffer)
-{
- return (buffer[0] | (buffer[1] << 8));
-}
-
-inline
-void
-packInt32(uint8_t* buffer, uint32_t value)
-{
- buffer[0] = value;
- buffer[1] = value >> 8;
- buffer[2] = value >> 16;
- buffer[3] = value >> 24;
-}
-
-static inline
-int
-bgzf_min(int x, int y)
-{
- return (x < y) ? x : y;
-}
-
-static
-void
-report_error(BGZF* fp, const char* message) {
- fp->error = message;
-}
-
-static BGZF *bgzf_read_init()
-{
- BGZF *fp;
- fp = calloc(1, sizeof(BGZF));
- fp->uncompressed_block_size = MAX_BLOCK_SIZE;
- fp->uncompressed_block = malloc(MAX_BLOCK_SIZE);
- fp->compressed_block_size = MAX_BLOCK_SIZE;
- fp->compressed_block = malloc(MAX_BLOCK_SIZE);
- fp->cache_size = 0;
- fp->cache = kh_init(cache);
- return fp;
-}
-
-static
-BGZF*
-open_read(int fd)
-{
-#ifdef _USE_KNETFILE
- knetFile *file = knet_dopen(fd, "r");
-#else
- FILE* file = fdopen(fd, "r");
-#endif
- BGZF* fp;
- if (file == 0) return 0;
- fp = bgzf_read_init();
- fp->file_descriptor = fd;
- fp->open_mode = 'r';
-#ifdef _USE_KNETFILE
- fp->x.fpr = file;
-#else
- fp->file = file;
-#endif
- return fp;
-}
-
-static
-BGZF*
-open_write(int fd, bool is_uncompressed)
-{
- FILE* file = fdopen(fd, "w");
- BGZF* fp;
- if (file == 0) return 0;
- fp = malloc(sizeof(BGZF));
- fp->file_descriptor = fd;
- fp->open_mode = 'w';
- fp->owned_file = 0; fp->is_uncompressed = is_uncompressed;
-#ifdef _USE_KNETFILE
- fp->x.fpw = file;
-#else
- fp->file = file;
-#endif
- fp->uncompressed_block_size = DEFAULT_BLOCK_SIZE;
- fp->uncompressed_block = NULL;
- fp->compressed_block_size = MAX_BLOCK_SIZE;
- fp->compressed_block = malloc(MAX_BLOCK_SIZE);
- fp->block_address = 0;
- fp->block_offset = 0;
- fp->block_length = 0;
- fp->error = NULL;
- return fp;
-}
-
-BGZF*
-bgzf_open(const char* __restrict path, const char* __restrict mode)
-{
- BGZF* fp = NULL;
- if (mode[0] == 'r' || mode[0] == 'R') { /* The reading mode is preferred. */
-#ifdef _USE_KNETFILE
- knetFile *file = knet_open(path, mode);
- if (file == 0) return 0;
- fp = bgzf_read_init();
- fp->file_descriptor = -1;
- fp->open_mode = 'r';
- fp->x.fpr = file;
-#else
- int fd, oflag = O_RDONLY;
-#ifdef _WIN32
- oflag |= O_BINARY;
-#endif
- fd = open(path, oflag);
- if (fd == -1) return 0;
- fp = open_read(fd);
-#endif
- } else if (mode[0] == 'w' || mode[0] == 'W') {
- int fd, oflag = O_WRONLY | O_CREAT | O_TRUNC;
-#ifdef _WIN32
- oflag |= O_BINARY;
-#endif
- fd = open(path, oflag, 0666);
- if (fd == -1) return 0;
- fp = open_write(fd, strstr(mode, "u")? 1 : 0);
- }
- if (fp != NULL) fp->owned_file = 1;
- return fp;
-}
-
-BGZF*
-bgzf_fdopen(int fd, const char * __restrict mode)
-{
- if (fd == -1) return 0;
- if (mode[0] == 'r' || mode[0] == 'R') {
- return open_read(fd);
- } else if (mode[0] == 'w' || mode[0] == 'W') {
- return open_write(fd, strstr(mode, "u")? 1 : 0);
- } else {
- return NULL;
- }
-}
-
-static
-int
-deflate_block(BGZF* fp, int block_length)
-{
- // Deflate the block in fp->uncompressed_block into fp->compressed_block.
- // Also adds an extra field that stores the compressed block length.
-
- bgzf_byte_t* buffer = fp->compressed_block;
- int buffer_size = fp->compressed_block_size;
-
- // Init gzip header
- buffer[0] = GZIP_ID1;
- buffer[1] = GZIP_ID2;
- buffer[2] = CM_DEFLATE;
- buffer[3] = FLG_FEXTRA;
- buffer[4] = 0; // mtime
- buffer[5] = 0;
- buffer[6] = 0;
- buffer[7] = 0;
- buffer[8] = 0;
- buffer[9] = OS_UNKNOWN;
- buffer[10] = BGZF_XLEN;
- buffer[11] = 0;
- buffer[12] = BGZF_ID1;
- buffer[13] = BGZF_ID2;
- buffer[14] = BGZF_LEN;
- buffer[15] = 0;
- buffer[16] = 0; // placeholder for block length
- buffer[17] = 0;
-
- // loop to retry for blocks that do not compress enough
- int input_length = block_length;
- int compressed_length = 0;
- while (1) {
- int compress_level = fp->is_uncompressed? 0 : Z_DEFAULT_COMPRESSION;
- z_stream zs;
- zs.zalloc = NULL;
- zs.zfree = NULL;
- zs.next_in = fp->uncompressed_block;
- zs.avail_in = input_length;
- zs.next_out = (void*)&buffer[BLOCK_HEADER_LENGTH];
- zs.avail_out = buffer_size - BLOCK_HEADER_LENGTH - BLOCK_FOOTER_LENGTH;
-
- int status = deflateInit2(&zs, compress_level, Z_DEFLATED,
- GZIP_WINDOW_BITS, Z_DEFAULT_MEM_LEVEL, Z_DEFAULT_STRATEGY);
- if (status != Z_OK) {
- report_error(fp, "deflate init failed");
- return -1;
- }
- status = deflate(&zs, Z_FINISH);
- if (status != Z_STREAM_END) {
- deflateEnd(&zs);
- if (status == Z_OK) {
- // Not enough space in buffer.
- // Can happen in the rare case the input doesn't compress enough.
- // Reduce the amount of input until it fits.
- input_length -= 1024;
- if (input_length <= 0) {
- // should never happen
- report_error(fp, "input reduction failed");
- return -1;
- }
- continue;
- }
- report_error(fp, "deflate failed");
- return -1;
- }
- status = deflateEnd(&zs);
- if (status != Z_OK) {
- report_error(fp, "deflate end failed");
- return -1;
- }
- compressed_length = zs.total_out;
- compressed_length += BLOCK_HEADER_LENGTH + BLOCK_FOOTER_LENGTH;
- if (compressed_length > MAX_BLOCK_SIZE) {
- // should never happen
- report_error(fp, "deflate overflow");
- return -1;
- }
- break;
- }
-
- packInt16((uint8_t*)&buffer[16], compressed_length-1);
- uint32_t crc = crc32(0L, NULL, 0L);
- crc = crc32(crc, fp->uncompressed_block, input_length);
- packInt32((uint8_t*)&buffer[compressed_length-8], crc);
- packInt32((uint8_t*)&buffer[compressed_length-4], input_length);
-
- int remaining = block_length - input_length;
- if (remaining > 0) {
- if (remaining > input_length) {
- // should never happen (check so we can use memcpy)
- report_error(fp, "remainder too large");
- return -1;
- }
- memcpy(fp->uncompressed_block,
- fp->uncompressed_block + input_length,
- remaining);
- }
- fp->block_offset = remaining;
- return compressed_length;
-}
-
-static
-int
-inflate_block(BGZF* fp, int block_length)
-{
- // Inflate the block in fp->compressed_block into fp->uncompressed_block
-
- z_stream zs;
- zs.zalloc = NULL;
- zs.zfree = NULL;
- zs.next_in = fp->compressed_block + 18;
- zs.avail_in = block_length - 16;
- zs.next_out = fp->uncompressed_block;
- zs.avail_out = fp->uncompressed_block_size;
-
- int status = inflateInit2(&zs, GZIP_WINDOW_BITS);
- if (status != Z_OK) {
- report_error(fp, "inflate init failed");
- return -1;
- }
- status = inflate(&zs, Z_FINISH);
- if (status != Z_STREAM_END) {
- inflateEnd(&zs);
- report_error(fp, "inflate failed");
- return -1;
- }
- status = inflateEnd(&zs);
- if (status != Z_OK) {
- report_error(fp, "inflate failed");
- return -1;
- }
- return zs.total_out;
-}
-
-static
-int
-check_header(const bgzf_byte_t* header)
-{
- return (header[0] == GZIP_ID1 &&
- header[1] == (bgzf_byte_t) GZIP_ID2 &&
- header[2] == Z_DEFLATED &&
- (header[3] & FLG_FEXTRA) != 0 &&
- unpackInt16((uint8_t*)&header[10]) == BGZF_XLEN &&
- header[12] == BGZF_ID1 &&
- header[13] == BGZF_ID2 &&
- unpackInt16((uint8_t*)&header[14]) == BGZF_LEN);
-}
-
-static void free_cache(BGZF *fp)
-{
- khint_t k;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- if (fp->open_mode != 'r') return;
- for (k = kh_begin(h); k < kh_end(h); ++k)
- if (kh_exist(h, k)) free(kh_val(h, k).block);
- kh_destroy(cache, h);
-}
-
-static int load_block_from_cache(BGZF *fp, int64_t block_address)
-{
- khint_t k;
- cache_t *p;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- k = kh_get(cache, h, block_address);
- if (k == kh_end(h)) return 0;
- p = &kh_val(h, k);
- if (fp->block_length != 0) fp->block_offset = 0;
- fp->block_address = block_address;
- fp->block_length = p->size;
- memcpy(fp->uncompressed_block, p->block, MAX_BLOCK_SIZE);
-#ifdef _USE_KNETFILE
- knet_seek(fp->x.fpr, p->end_offset, SEEK_SET);
-#else
- fseeko(fp->file, p->end_offset, SEEK_SET);
-#endif
- return p->size;
-}
-
-static void cache_block(BGZF *fp, int size)
-{
- int ret;
- khint_t k;
- cache_t *p;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- if (MAX_BLOCK_SIZE >= fp->cache_size) return;
- if ((kh_size(h) + 1) * MAX_BLOCK_SIZE > fp->cache_size) {
- /* A better way would be to remove the oldest block in the
- * cache, but here we remove a random one for simplicity. This
- * should not have a big impact on performance. */
- for (k = kh_begin(h); k < kh_end(h); ++k)
- if (kh_exist(h, k)) break;
- if (k < kh_end(h)) {
- free(kh_val(h, k).block);
- kh_del(cache, h, k);
- }
- }
- k = kh_put(cache, h, fp->block_address, &ret);
- if (ret == 0) return; // if this happens, a bug!
- p = &kh_val(h, k);
- p->size = fp->block_length;
- p->end_offset = fp->block_address + size;
- p->block = malloc(MAX_BLOCK_SIZE);
- memcpy(kh_val(h, k).block, fp->uncompressed_block, MAX_BLOCK_SIZE);
-}
-
-int
-bgzf_read_block(BGZF* fp)
-{
- bgzf_byte_t header[BLOCK_HEADER_LENGTH];
- int count, size = 0;
-#ifdef _USE_KNETFILE
- int64_t block_address = knet_tell(fp->x.fpr);
- if (load_block_from_cache(fp, block_address)) return 0;
- count = knet_read(fp->x.fpr, header, sizeof(header));
-#else
- int64_t block_address = ftello(fp->file);
- if (load_block_from_cache(fp, block_address)) return 0;
- count = fread(header, 1, sizeof(header), fp->file);
-#endif
- if (count == 0) {
- fp->block_length = 0;
- return 0;
- }
- size = count;
- if (count != sizeof(header)) {
- report_error(fp, "read failed");
- return -1;
- }
- if (!check_header(header)) {
- report_error(fp, "invalid block header");
- return -1;
- }
- int block_length = unpackInt16((uint8_t*)&header[16]) + 1;
- bgzf_byte_t* compressed_block = (bgzf_byte_t*) fp->compressed_block;
- memcpy(compressed_block, header, BLOCK_HEADER_LENGTH);
- int remaining = block_length - BLOCK_HEADER_LENGTH;
-#ifdef _USE_KNETFILE
- count = knet_read(fp->x.fpr, &compressed_block[BLOCK_HEADER_LENGTH], remaining);
-#else
- count = fread(&compressed_block[BLOCK_HEADER_LENGTH], 1, remaining, fp->file);
-#endif
- if (count != remaining) {
- report_error(fp, "read failed");
- return -1;
- }
- size += count;
- count = inflate_block(fp, block_length);
- if (count < 0) return -1;
- if (fp->block_length != 0) {
- // Do not reset offset if this read follows a seek.
- fp->block_offset = 0;
- }
- fp->block_address = block_address;
- fp->block_length = count;
- cache_block(fp, size);
- return 0;
-}
-
-int
-bgzf_read(BGZF* fp, void* data, int length)
-{
- if (length <= 0) {
- return 0;
- }
- if (fp->open_mode != 'r') {
- report_error(fp, "file not open for reading");
- return -1;
- }
-
- int bytes_read = 0;
- bgzf_byte_t* output = data;
- while (bytes_read < length) {
- int available = fp->block_length - fp->block_offset;
- if (available <= 0) {
- if (bgzf_read_block(fp) != 0) {
- return -1;
- }
- available = fp->block_length - fp->block_offset;
- if (available <= 0) {
- break;
- }
- }
- int copy_length = bgzf_min(length-bytes_read, available);
- bgzf_byte_t* buffer = fp->uncompressed_block;
- memcpy(output, buffer + fp->block_offset, copy_length);
- fp->block_offset += copy_length;
- output += copy_length;
- bytes_read += copy_length;
- }
- if (fp->block_offset == fp->block_length) {
-#ifdef _USE_KNETFILE
- fp->block_address = knet_tell(fp->x.fpr);
-#else
- fp->block_address = ftello(fp->file);
-#endif
- fp->block_offset = 0;
- fp->block_length = 0;
- }
- return bytes_read;
-}
-
-int bgzf_flush(BGZF* fp)
-{
- while (fp->block_offset > 0) {
- int count, block_length;
- block_length = deflate_block(fp, fp->block_offset);
- if (block_length < 0) return -1;
-#ifdef _USE_KNETFILE
- count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
-#else
- count = fwrite(fp->compressed_block, 1, block_length, fp->file);
-#endif
- if (count != block_length) {
- report_error(fp, "write failed");
- return -1;
- }
- fp->block_address += block_length;
- }
- return 0;
-}
-
-int bgzf_flush_try(BGZF *fp, int size)
-{
- if (fp->block_offset + size > fp->uncompressed_block_size)
- return bgzf_flush(fp);
- return -1;
-}
-
-int bgzf_write(BGZF* fp, const void* data, int length)
-{
- if (fp->open_mode != 'w') {
- report_error(fp, "file not open for writing");
- return -1;
- }
-
- if (fp->uncompressed_block == NULL)
- fp->uncompressed_block = malloc(fp->uncompressed_block_size);
-
- const bgzf_byte_t* input = data;
- int block_length = fp->uncompressed_block_size;
- int bytes_written = 0;
- while (bytes_written < length) {
- int copy_length = bgzf_min(block_length - fp->block_offset, length - bytes_written);
- bgzf_byte_t* buffer = fp->uncompressed_block;
- memcpy(buffer + fp->block_offset, input, copy_length);
- fp->block_offset += copy_length;
- input += copy_length;
- bytes_written += copy_length;
- if (fp->block_offset == block_length) {
- if (bgzf_flush(fp) != 0) {
- break;
- }
- }
- }
- return bytes_written;
-}
-
-int bgzf_close(BGZF* fp)
-{
- if (fp->open_mode == 'w') {
- if (bgzf_flush(fp) != 0) return -1;
- { // add an empty block
- int count, block_length = deflate_block(fp, 0);
-#ifdef _USE_KNETFILE
- count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
-#else
- count = fwrite(fp->compressed_block, 1, block_length, fp->file);
-#endif
- }
-#ifdef _USE_KNETFILE
- if (fflush(fp->x.fpw) != 0) {
-#else
- if (fflush(fp->file) != 0) {
-#endif
- report_error(fp, "flush failed");
- return -1;
- }
- }
- if (fp->owned_file) {
-#ifdef _USE_KNETFILE
- int ret;
- if (fp->open_mode == 'w') ret = fclose(fp->x.fpw);
- else ret = knet_close(fp->x.fpr);
- if (ret != 0) return -1;
-#else
- if (fclose(fp->file) != 0) return -1;
-#endif
- }
- free(fp->uncompressed_block);
- free(fp->compressed_block);
- free_cache(fp);
- free(fp);
- return 0;
-}
-
-void bgzf_set_cache_size(BGZF *fp, int cache_size)
-{
- if (fp) fp->cache_size = cache_size;
-}
-
-int bgzf_check_EOF(BGZF *fp)
-{
- static uint8_t magic[28] = "\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\033\0\3\0\0\0\0\0\0\0\0\0";
- uint8_t buf[28];
- off_t offset;
-#ifdef _USE_KNETFILE
- offset = knet_tell(fp->x.fpr);
- if (knet_seek(fp->x.fpr, -28, SEEK_END) != 0) return -1;
- knet_read(fp->x.fpr, buf, 28);
- knet_seek(fp->x.fpr, offset, SEEK_SET);
-#else
- offset = ftello(fp->file);
- if (fseeko(fp->file, -28, SEEK_END) != 0) return -1;
- fread(buf, 1, 28, fp->file);
- fseeko(fp->file, offset, SEEK_SET);
-#endif
- return (memcmp(magic, buf, 28) == 0)? 1 : 0;
-}
-
-int64_t bgzf_seek(BGZF* fp, int64_t pos, int where)
-{
- int block_offset;
- int64_t block_address;
-
- if (fp->open_mode != 'r') {
- report_error(fp, "file not open for read");
- return -1;
- }
- if (where != SEEK_SET) {
- report_error(fp, "unimplemented seek option");
- return -1;
- }
- block_offset = pos & 0xFFFF;
- block_address = (pos >> 16) & 0xFFFFFFFFFFFFLL;
-#ifdef _USE_KNETFILE
- if (knet_seek(fp->x.fpr, block_address, SEEK_SET) != 0) {
-#else
- if (fseeko(fp->file, block_address, SEEK_SET) != 0) {
-#endif
- report_error(fp, "seek failed");
- return -1;
- }
- fp->block_length = 0; // indicates current block is not loaded
- fp->block_address = block_address;
- fp->block_offset = block_offset;
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
+
+ Permission is hereby granted, free of charge, to any person obtaining a copy
+ of this software and associated documentation files (the "Software"), to deal
+ in the Software without restriction, including without limitation the rights
+ to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+ copies of the Software, and to permit persons to whom the Software is
+ furnished to do so, subject to the following conditions:
+
+ The above copyright notice and this permission notice shall be included in
+ all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+ IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+ FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+ LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+ OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
+ THE SOFTWARE.
+*/
+
+/*
+ 2009-06-29 by lh3: cache recent uncompressed blocks.
+ 2009-06-25 by lh3: optionally use my knetfile library to access file on a FTP.
+ 2009-06-12 by lh3: support a mode string like "wu" where 'u' for uncompressed output */
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+#include <unistd.h>
+#include <fcntl.h>
+#include <sys/types.h>
+#include <sys/stat.h>
+#include "bgzf.h"
+
+#include "khash.h"
+typedef struct {
+ int size;
+ uint8_t *block;
+ int64_t end_offset;
+} cache_t;
+KHASH_MAP_INIT_INT64(cache, cache_t)
+
+#if defined(_WIN32) || defined(_MSC_VER)
+#define ftello(fp) ftell(fp)
+#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
+#else
+extern off_t ftello(FILE *stream);
+extern int fseeko(FILE *stream, off_t offset, int whence);
+#endif
+
+typedef int8_t bgzf_byte_t;
+
+static const int DEFAULT_BLOCK_SIZE = 64 * 1024;
+static const int MAX_BLOCK_SIZE = 64 * 1024;
+
+static const int BLOCK_HEADER_LENGTH = 18;
+static const int BLOCK_FOOTER_LENGTH = 8;
+
+static const int GZIP_ID1 = 31;
+static const int GZIP_ID2 = 139;
+static const int CM_DEFLATE = 8;
+static const int FLG_FEXTRA = 4;
+static const int OS_UNKNOWN = 255;
+static const int BGZF_ID1 = 66; // 'B'
+static const int BGZF_ID2 = 67; // 'C'
+static const int BGZF_LEN = 2;
+static const int BGZF_XLEN = 6; // BGZF_LEN+4
+
+static const int GZIP_WINDOW_BITS = -15; // no zlib header
+static const int Z_DEFAULT_MEM_LEVEL = 8;
+
+
+inline
+void
+packInt16(uint8_t* buffer, uint16_t value)
+{
+ buffer[0] = value;
+ buffer[1] = value >> 8;
+}
+
+inline
+int
+unpackInt16(const uint8_t* buffer)
+{
+ return (buffer[0] | (buffer[1] << 8));
+}
+
+inline
+void
+packInt32(uint8_t* buffer, uint32_t value)
+{
+ buffer[0] = value;
+ buffer[1] = value >> 8;
+ buffer[2] = value >> 16;
+ buffer[3] = value >> 24;
+}
+
+static inline
+int
+bgzf_min(int x, int y)
+{
+ return (x < y) ? x : y;
+}
+
+static
+void
+report_error(BGZF* fp, const char* message) {
+ fp->error = message;
+}
+
+int bgzf_check_bgzf(const char *fn)
+{
+ BGZF *fp;
+ uint8_t buf[10],magic[10]="\037\213\010\4\0\0\0\0\0\377";
+ int n;
+
+ if ((fp = bgzf_open(fn, "r")) == 0)
+ {
+ fprintf(pysamerr, "[bgzf_check_bgzf] failed to open the file: %s\n",fn);
+ return -1;
+ }
+
+#ifdef _USE_KNETFILE
+ n = knet_read(fp->x.fpr, buf, 10);
+#else
+ n = fread(buf, 1, 10, fp->file);
+#endif
+ bgzf_close(fp);
+
+ if ( n!=10 )
+ return -1;
+
+ if ( !memcmp(magic, buf, 10) ) return 1;
+ return 0;
+}
+
+static BGZF *bgzf_read_init()
+{
+ BGZF *fp;
+ fp = calloc(1, sizeof(BGZF));
+ fp->uncompressed_block_size = MAX_BLOCK_SIZE;
+ fp->uncompressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->compressed_block_size = MAX_BLOCK_SIZE;
+ fp->compressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->cache_size = 0;
+ fp->cache = kh_init(cache);
+ return fp;
+}
+
+static
+BGZF*
+open_read(int fd)
+{
+#ifdef _USE_KNETFILE
+ knetFile *file = knet_dopen(fd, "r");
+#else
+ FILE* file = fdopen(fd, "r");
+#endif
+ BGZF* fp;
+ if (file == 0) return 0;
+ fp = bgzf_read_init();
+ fp->file_descriptor = fd;
+ fp->open_mode = 'r';
+#ifdef _USE_KNETFILE
+ fp->x.fpr = file;
+#else
+ fp->file = file;
+#endif
+ return fp;
+}
+
+static
+BGZF*
+open_write(int fd, int compress_level) // compress_level==-1 for the default level
+{
+ FILE* file = fdopen(fd, "w");
+ BGZF* fp;
+ if (file == 0) return 0;
+ fp = malloc(sizeof(BGZF));
+ fp->file_descriptor = fd;
+ fp->open_mode = 'w';
+ fp->owned_file = 0;
+ fp->compress_level = compress_level < 0? Z_DEFAULT_COMPRESSION : compress_level; // Z_DEFAULT_COMPRESSION==-1
+ if (fp->compress_level > 9) fp->compress_level = Z_DEFAULT_COMPRESSION;
+#ifdef _USE_KNETFILE
+ fp->x.fpw = file;
+#else
+ fp->file = file;
+#endif
+ fp->uncompressed_block_size = DEFAULT_BLOCK_SIZE;
+ fp->uncompressed_block = NULL;
+ fp->compressed_block_size = MAX_BLOCK_SIZE;
+ fp->compressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->block_address = 0;
+ fp->block_offset = 0;
+ fp->block_length = 0;
+ fp->error = NULL;
+ return fp;
+}
+
+BGZF*
+bgzf_open(const char* __restrict path, const char* __restrict mode)
+{
+ BGZF* fp = NULL;
+ if (strchr(mode, 'r') || strchr(mode, 'R')) { /* The reading mode is preferred. */
+#ifdef _USE_KNETFILE
+ knetFile *file = knet_open(path, mode);
+ if (file == 0) return 0;
+ fp = bgzf_read_init();
+ fp->file_descriptor = -1;
+ fp->open_mode = 'r';
+ fp->x.fpr = file;
+#else
+ int fd, oflag = O_RDONLY;
+#ifdef _WIN32
+ oflag |= O_BINARY;
+#endif
+ fd = open(path, oflag);
+ if (fd == -1) return 0;
+ fp = open_read(fd);
+#endif
+ } else if (strchr(mode, 'w') || strchr(mode, 'W')) {
+ int fd, compress_level = -1, oflag = O_WRONLY | O_CREAT | O_TRUNC;
+#ifdef _WIN32
+ oflag |= O_BINARY;
+#endif
+ fd = open(path, oflag, 0666);
+ if (fd == -1) return 0;
+ { // set compress_level
+ int i;
+ for (i = 0; mode[i]; ++i)
+ if (mode[i] >= '0' && mode[i] <= '9') break;
+ if (mode[i]) compress_level = (int)mode[i] - '0';
+ if (strchr(mode, 'u')) compress_level = 0;
+ }
+ fp = open_write(fd, compress_level);
+ }
+ if (fp != NULL) fp->owned_file = 1;
+ return fp;
+}
+
+BGZF*
+bgzf_fdopen(int fd, const char * __restrict mode)
+{
+ if (fd == -1) return 0;
+ if (mode[0] == 'r' || mode[0] == 'R') {
+ return open_read(fd);
+ } else if (mode[0] == 'w' || mode[0] == 'W') {
+ int i, compress_level = -1;
+ for (i = 0; mode[i]; ++i)
+ if (mode[i] >= '0' && mode[i] <= '9') break;
+ if (mode[i]) compress_level = (int)mode[i] - '0';
+ if (strchr(mode, 'u')) compress_level = 0;
+ return open_write(fd, compress_level);
+ } else {
+ return NULL;
+ }
+}
+
+static
+int
+deflate_block(BGZF* fp, int block_length)
+{
+ // Deflate the block in fp->uncompressed_block into fp->compressed_block.
+ // Also adds an extra field that stores the compressed block length.
+
+ bgzf_byte_t* buffer = fp->compressed_block;
+ int buffer_size = fp->compressed_block_size;
+
+ // Init gzip header
+ buffer[0] = GZIP_ID1;
+ buffer[1] = GZIP_ID2;
+ buffer[2] = CM_DEFLATE;
+ buffer[3] = FLG_FEXTRA;
+ buffer[4] = 0; // mtime
+ buffer[5] = 0;
+ buffer[6] = 0;
+ buffer[7] = 0;
+ buffer[8] = 0;
+ buffer[9] = OS_UNKNOWN;
+ buffer[10] = BGZF_XLEN;
+ buffer[11] = 0;
+ buffer[12] = BGZF_ID1;
+ buffer[13] = BGZF_ID2;
+ buffer[14] = BGZF_LEN;
+ buffer[15] = 0;
+ buffer[16] = 0; // placeholder for block length
+ buffer[17] = 0;
+
+ // loop to retry for blocks that do not compress enough
+ int input_length = block_length;
+ int compressed_length = 0;
+ while (1) {
+ z_stream zs;
+ zs.zalloc = NULL;
+ zs.zfree = NULL;
+ zs.next_in = fp->uncompressed_block;
+ zs.avail_in = input_length;
+ zs.next_out = (void*)&buffer[BLOCK_HEADER_LENGTH];
+ zs.avail_out = buffer_size - BLOCK_HEADER_LENGTH - BLOCK_FOOTER_LENGTH;
+
+ int status = deflateInit2(&zs, fp->compress_level, Z_DEFLATED,
+ GZIP_WINDOW_BITS, Z_DEFAULT_MEM_LEVEL, Z_DEFAULT_STRATEGY);
+ if (status != Z_OK) {
+ report_error(fp, "deflate init failed");
+ return -1;
+ }
+ status = deflate(&zs, Z_FINISH);
+ if (status != Z_STREAM_END) {
+ deflateEnd(&zs);
+ if (status == Z_OK) {
+ // Not enough space in buffer.
+ // Can happen in the rare case the input doesn't compress enough.
+ // Reduce the amount of input until it fits.
+ input_length -= 1024;
+ if (input_length <= 0) {
+ // should never happen
+ report_error(fp, "input reduction failed");
+ return -1;
+ }
+ continue;
+ }
+ report_error(fp, "deflate failed");
+ return -1;
+ }
+ status = deflateEnd(&zs);
+ if (status != Z_OK) {
+ report_error(fp, "deflate end failed");
+ return -1;
+ }
+ compressed_length = zs.total_out;
+ compressed_length += BLOCK_HEADER_LENGTH + BLOCK_FOOTER_LENGTH;
+ if (compressed_length > MAX_BLOCK_SIZE) {
+ // should never happen
+ report_error(fp, "deflate overflow");
+ return -1;
+ }
+ break;
+ }
+
+ packInt16((uint8_t*)&buffer[16], compressed_length-1);
+ uint32_t crc = crc32(0L, NULL, 0L);
+ crc = crc32(crc, fp->uncompressed_block, input_length);
+ packInt32((uint8_t*)&buffer[compressed_length-8], crc);
+ packInt32((uint8_t*)&buffer[compressed_length-4], input_length);
+
+ int remaining = block_length - input_length;
+ if (remaining > 0) {
+ if (remaining > input_length) {
+ // should never happen (check so we can use memcpy)
+ report_error(fp, "remainder too large");
+ return -1;
+ }
+ memcpy(fp->uncompressed_block,
+ fp->uncompressed_block + input_length,
+ remaining);
+ }
+ fp->block_offset = remaining;
+ return compressed_length;
+}
+
+static
+int
+inflate_block(BGZF* fp, int block_length)
+{
+ // Inflate the block in fp->compressed_block into fp->uncompressed_block
+
+ z_stream zs;
+ int status;
+ zs.zalloc = NULL;
+ zs.zfree = NULL;
+ zs.next_in = fp->compressed_block + 18;
+ zs.avail_in = block_length - 16;
+ zs.next_out = fp->uncompressed_block;
+ zs.avail_out = fp->uncompressed_block_size;
+
+ status = inflateInit2(&zs, GZIP_WINDOW_BITS);
+ if (status != Z_OK) {
+ report_error(fp, "inflate init failed");
+ return -1;
+ }
+ status = inflate(&zs, Z_FINISH);
+ if (status != Z_STREAM_END) {
+ inflateEnd(&zs);
+ report_error(fp, "inflate failed");
+ return -1;
+ }
+ status = inflateEnd(&zs);
+ if (status != Z_OK) {
+ report_error(fp, "inflate failed");
+ return -1;
+ }
+ return zs.total_out;
+}
+
+static
+int
+check_header(const bgzf_byte_t* header)
+{
+ return (header[0] == GZIP_ID1 &&
+ header[1] == (bgzf_byte_t) GZIP_ID2 &&
+ header[2] == Z_DEFLATED &&
+ (header[3] & FLG_FEXTRA) != 0 &&
+ unpackInt16((uint8_t*)&header[10]) == BGZF_XLEN &&
+ header[12] == BGZF_ID1 &&
+ header[13] == BGZF_ID2 &&
+ unpackInt16((uint8_t*)&header[14]) == BGZF_LEN);
+}
+
+static void free_cache(BGZF *fp)
+{
+ khint_t k;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ if (fp->open_mode != 'r') return;
+ for (k = kh_begin(h); k < kh_end(h); ++k)
+ if (kh_exist(h, k)) free(kh_val(h, k).block);
+ kh_destroy(cache, h);
+}
+
+static int load_block_from_cache(BGZF *fp, int64_t block_address)
+{
+ khint_t k;
+ cache_t *p;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ k = kh_get(cache, h, block_address);
+ if (k == kh_end(h)) return 0;
+ p = &kh_val(h, k);
+ if (fp->block_length != 0) fp->block_offset = 0;
+ fp->block_address = block_address;
+ fp->block_length = p->size;
+ memcpy(fp->uncompressed_block, p->block, MAX_BLOCK_SIZE);
+#ifdef _USE_KNETFILE
+ knet_seek(fp->x.fpr, p->end_offset, SEEK_SET);
+#else
+ fseeko(fp->file, p->end_offset, SEEK_SET);
+#endif
+ return p->size;
+}
+
+static void cache_block(BGZF *fp, int size)
+{
+ int ret;
+ khint_t k;
+ cache_t *p;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ if (MAX_BLOCK_SIZE >= fp->cache_size) return;
+ if ((kh_size(h) + 1) * MAX_BLOCK_SIZE > fp->cache_size) {
+ /* A better way would be to remove the oldest block in the
+ * cache, but here we remove a random one for simplicity. This
+ * should not have a big impact on performance. */
+ for (k = kh_begin(h); k < kh_end(h); ++k)
+ if (kh_exist(h, k)) break;
+ if (k < kh_end(h)) {
+ free(kh_val(h, k).block);
+ kh_del(cache, h, k);
+ }
+ }
+ k = kh_put(cache, h, fp->block_address, &ret);
+ if (ret == 0) return; // if this happens, a bug!
+ p = &kh_val(h, k);
+ p->size = fp->block_length;
+ p->end_offset = fp->block_address + size;
+ p->block = malloc(MAX_BLOCK_SIZE);
+ memcpy(kh_val(h, k).block, fp->uncompressed_block, MAX_BLOCK_SIZE);
+}
+
+int
+bgzf_read_block(BGZF* fp)
+{
+ bgzf_byte_t header[BLOCK_HEADER_LENGTH];
+ int count, size = 0, block_length, remaining;
+#ifdef _USE_KNETFILE
+ int64_t block_address = knet_tell(fp->x.fpr);
+ if (load_block_from_cache(fp, block_address)) return 0;
+ count = knet_read(fp->x.fpr, header, sizeof(header));
+#else
+ int64_t block_address = ftello(fp->file);
+ if (load_block_from_cache(fp, block_address)) return 0;
+ count = fread(header, 1, sizeof(header), fp->file);
+#endif
+ if (count == 0) {
+ fp->block_length = 0;
+ return 0;
+ }
+ size = count;
+ if (count != sizeof(header)) {
+ report_error(fp, "read failed");
+ return -1;
+ }
+ if (!check_header(header)) {
+ report_error(fp, "invalid block header");
+ return -1;
+ }
+ block_length = unpackInt16((uint8_t*)&header[16]) + 1;
+ bgzf_byte_t* compressed_block = (bgzf_byte_t*) fp->compressed_block;
+ memcpy(compressed_block, header, BLOCK_HEADER_LENGTH);
+ remaining = block_length - BLOCK_HEADER_LENGTH;
+#ifdef _USE_KNETFILE
+ count = knet_read(fp->x.fpr, &compressed_block[BLOCK_HEADER_LENGTH], remaining);
+#else
+ count = fread(&compressed_block[BLOCK_HEADER_LENGTH], 1, remaining, fp->file);
+#endif
+ if (count != remaining) {
+ report_error(fp, "read failed");
+ return -1;
+ }
+ size += count;
+ count = inflate_block(fp, block_length);
+ if (count < 0) return -1;
+ if (fp->block_length != 0) {
+ // Do not reset offset if this read follows a seek.
+ fp->block_offset = 0;
+ }
+ fp->block_address = block_address;
+ fp->block_length = count;
+ cache_block(fp, size);
+ return 0;
+}
+
+int
+bgzf_read(BGZF* fp, void* data, int length)
+{
+ if (length <= 0) {
+ return 0;
+ }
+ if (fp->open_mode != 'r') {
+ report_error(fp, "file not open for reading");
+ return -1;
+ }
+
+ int bytes_read = 0;
+ bgzf_byte_t* output = data;
+ while (bytes_read < length) {
+ int copy_length, available = fp->block_length - fp->block_offset;
+ bgzf_byte_t *buffer;
+ if (available <= 0) {
+ if (bgzf_read_block(fp) != 0) {
+ return -1;
+ }
+ available = fp->block_length - fp->block_offset;
+ if (available <= 0) {
+ break;
+ }
+ }
+ copy_length = bgzf_min(length-bytes_read, available);
+ buffer = fp->uncompressed_block;
+ memcpy(output, buffer + fp->block_offset, copy_length);
+ fp->block_offset += copy_length;
+ output += copy_length;
+ bytes_read += copy_length;
+ }
+ if (fp->block_offset == fp->block_length) {
+#ifdef _USE_KNETFILE
+ fp->block_address = knet_tell(fp->x.fpr);
+#else
+ fp->block_address = ftello(fp->file);
+#endif
+ fp->block_offset = 0;
+ fp->block_length = 0;
+ }
+ return bytes_read;
+}
+
+int bgzf_flush(BGZF* fp)
+{
+ while (fp->block_offset > 0) {
+ int count, block_length;
+ block_length = deflate_block(fp, fp->block_offset);
+ if (block_length < 0) return -1;
+#ifdef _USE_KNETFILE
+ count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
+#else
+ count = fwrite(fp->compressed_block, 1, block_length, fp->file);
+#endif
+ if (count != block_length) {
+ report_error(fp, "write failed");
+ return -1;
+ }
+ fp->block_address += block_length;
+ }
+ return 0;
+}
+
+int bgzf_flush_try(BGZF *fp, int size)
+{
+ if (fp->block_offset + size > fp->uncompressed_block_size)
+ return bgzf_flush(fp);
+ return -1;
+}
+
+int bgzf_write(BGZF* fp, const void* data, int length)
+{
+ const bgzf_byte_t *input = data;
+ int block_length, bytes_written;
+ if (fp->open_mode != 'w') {
+ report_error(fp, "file not open for writing");
+ return -1;
+ }
+
+ if (fp->uncompressed_block == NULL)
+ fp->uncompressed_block = malloc(fp->uncompressed_block_size);
+
+ input = data;
+ block_length = fp->uncompressed_block_size;
+ bytes_written = 0;
+ while (bytes_written < length) {
+ int copy_length = bgzf_min(block_length - fp->block_offset, length - bytes_written);
+ bgzf_byte_t* buffer = fp->uncompressed_block;
+ memcpy(buffer + fp->block_offset, input, copy_length);
+ fp->block_offset += copy_length;
+ input += copy_length;
+ bytes_written += copy_length;
+ if (fp->block_offset == block_length) {
+ if (bgzf_flush(fp) != 0) {
+ break;
+ }
+ }
+ }
+ return bytes_written;
+}
+
+int bgzf_close(BGZF* fp)
+{
+ if (fp->open_mode == 'w') {
+ if (bgzf_flush(fp) != 0) return -1;
+ { // add an empty block
+ int count, block_length = deflate_block(fp, 0);
+#ifdef _USE_KNETFILE
+ count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
+#else
+ count = fwrite(fp->compressed_block, 1, block_length, fp->file);
+#endif
+ }
+#ifdef _USE_KNETFILE
+ if (fflush(fp->x.fpw) != 0) {
+#else
+ if (fflush(fp->file) != 0) {
+#endif
+ report_error(fp, "flush failed");
+ return -1;
+ }
+ }
+ if (fp->owned_file) {
+#ifdef _USE_KNETFILE
+ int ret;
+ if (fp->open_mode == 'w') ret = fclose(fp->x.fpw);
+ else ret = knet_close(fp->x.fpr);
+ if (ret != 0) return -1;
+#else
+ if (fclose(fp->file) != 0) return -1;
+#endif
+ }
+ free(fp->uncompressed_block);
+ free(fp->compressed_block);
+ free_cache(fp);
+ free(fp);
+ return 0;
+}
+
+void bgzf_set_cache_size(BGZF *fp, int cache_size)
+{
+ if (fp) fp->cache_size = cache_size;
+}
+
+int bgzf_check_EOF(BGZF *fp)
+{
+ static uint8_t magic[28] = "\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\033\0\3\0\0\0\0\0\0\0\0\0";
+ uint8_t buf[28];
+ off_t offset;
+#ifdef _USE_KNETFILE
+ offset = knet_tell(fp->x.fpr);
+ if (knet_seek(fp->x.fpr, -28, SEEK_END) != 0) return -1;
+ knet_read(fp->x.fpr, buf, 28);
+ knet_seek(fp->x.fpr, offset, SEEK_SET);
+#else
+ offset = ftello(fp->file);
+ if (fseeko(fp->file, -28, SEEK_END) != 0) return -1;
+ fread(buf, 1, 28, fp->file);
+ fseeko(fp->file, offset, SEEK_SET);
+#endif
+ return (memcmp(magic, buf, 28) == 0)? 1 : 0;
+}
+
+int64_t bgzf_seek(BGZF* fp, int64_t pos, int where)
+{
+ int block_offset;
+ int64_t block_address;
+
+ if (fp->open_mode != 'r') {
+ report_error(fp, "file not open for read");
+ return -1;
+ }
+ if (where != SEEK_SET) {
+ report_error(fp, "unimplemented seek option");
+ return -1;
+ }
+ block_offset = pos & 0xFFFF;
+ block_address = (pos >> 16) & 0xFFFFFFFFFFFFLL;
+#ifdef _USE_KNETFILE
+ if (knet_seek(fp->x.fpr, block_address, SEEK_SET) != 0) {
+#else
+ if (fseeko(fp->file, block_address, SEEK_SET) != 0) {
+#endif
+ report_error(fp, "seek failed");
+ return -1;
+ }
+ fp->block_length = 0; // indicates current block is not loaded
+ fp->block_address = block_address;
+ fp->block_offset = block_offset;
+ return 0;
+}
#include <stdint.h>
#include <stdio.h>
-#include <stdbool.h>
#include <zlib.h>
#ifdef _USE_KNETFILE
#include "knetfile.h"
typedef struct {
int file_descriptor;
char open_mode; // 'r' or 'w'
- bool owned_file, is_uncompressed;
+ int16_t owned_file, compress_level;
#ifdef _USE_KNETFILE
union {
knetFile *fpr;
int bgzf_read_block(BGZF* fp);
int bgzf_flush(BGZF* fp);
int bgzf_flush_try(BGZF *fp, int size);
+int bgzf_check_bgzf(const char *fn);
#ifdef __cplusplus
}
--- /dev/null
+#include "pysam.h"
+
+#include <unistd.h>
+#include <stdlib.h>
+#include <string.h>
+#include "bam.h"
+#include "errmod.h"
+#include "faidx.h"
+
+#define ERR_DEP 0.83f
+
+typedef struct {
+ int e[2][3], p[2][2];
+} score_param_t;
+
+/* Note that although the two matrics have 10 parameters in total, only 4
+ * (probably 3) are free. Changing the scoring matrices in a sort of symmetric
+ * way will not change the result. */
+static score_param_t g_param = { {{0,0,0},{-4,1,6}}, {{0,-14000}, {0,0}} };
+
+typedef struct {
+ int min_baseQ, tid, max_bases;
+ uint16_t *bases;
+ bamFile fp;
+ bam_header_t *h;
+ char *ref;
+ faidx_t *fai;
+ errmod_t *em;
+} ct_t;
+
+static uint16_t gencns(ct_t *g, int n, const bam_pileup1_t *plp)
+{
+ int i, j, ret, tmp, k, sum[4], qual;
+ float q[16];
+ if (n > g->max_bases) { // enlarge g->bases
+ g->max_bases = n;
+ kroundup32(g->max_bases);
+ g->bases = realloc(g->bases, g->max_bases * 2);
+ }
+ for (i = k = 0; i < n; ++i) {
+ const bam_pileup1_t *p = plp + i;
+ uint8_t *seq;
+ int q, baseQ, b;
+ if (p->is_refskip || p->is_del) continue;
+ baseQ = bam1_qual(p->b)[p->qpos];
+ if (baseQ < g->min_baseQ) continue;
+ seq = bam1_seq(p->b);
+ b = bam_nt16_nt4_table[bam1_seqi(seq, p->qpos)];
+ if (b > 3) continue;
+ q = baseQ < p->b->core.qual? baseQ : p->b->core.qual;
+ if (q < 4) q = 4;
+ if (q > 63) q = 63;
+ g->bases[k++] = q<<5 | bam1_strand(p->b)<<4 | b;
+ }
+ if (k == 0) return 0;
+ errmod_cal(g->em, k, 4, g->bases, q);
+ for (i = 0; i < 4; ++i) sum[i] = (int)(q[i<<2|i] + .499) << 2 | i;
+ for (i = 1; i < 4; ++i) // insertion sort
+ for (j = i; j > 0 && sum[j] < sum[j-1]; --j)
+ tmp = sum[j], sum[j] = sum[j-1], sum[j-1] = tmp;
+ qual = (sum[1]>>2) - (sum[0]>>2);
+ k = k < 256? k : 255;
+ ret = (qual < 63? qual : 63) << 2 | (sum[0]&3);
+ return ret<<8|k;
+}
+
+static void process_cns(bam_header_t *h, int tid, int l, uint16_t *cns)
+{
+ int i, f[2][2], *prev, *curr, *swap_tmp, s;
+ uint8_t *b; // backtrack array
+ b = calloc(l, 1);
+ f[0][0] = f[0][1] = 0;
+ prev = f[0]; curr = f[1];
+ // fill the backtrack matrix
+ for (i = 0; i < l; ++i) {
+ int c = (cns[i] == 0)? 0 : (cns[i]>>8 == 0)? 1 : 2;
+ int tmp0, tmp1;
+ // compute f[0]
+ tmp0 = prev[0] + g_param.e[0][c] + g_param.p[0][0]; // (s[i+1],s[i])=(0,0)
+ tmp1 = prev[1] + g_param.e[0][c] + g_param.p[1][0]; // (0,1)
+ if (tmp0 > tmp1) curr[0] = tmp0, b[i] = 0;
+ else curr[0] = tmp1, b[i] = 1;
+ // compute f[1]
+ tmp0 = prev[0] + g_param.e[1][c] + g_param.p[0][1]; // (s[i+1],s[i])=(1,0)
+ tmp1 = prev[1] + g_param.e[1][c] + g_param.p[1][1]; // (1,1)
+ if (tmp0 > tmp1) curr[1] = tmp0, b[i] |= 0<<1;
+ else curr[1] = tmp1, b[i] |= 1<<1;
+ // swap
+ swap_tmp = prev; prev = curr; curr = swap_tmp;
+ }
+ // backtrack
+ s = prev[0] > prev[1]? 0 : 1;
+ for (i = l - 1; i > 0; --i) {
+ b[i] |= s<<2;
+ s = b[i]>>s&1;
+ }
+ // print
+ for (i = 0, s = -1; i <= l; ++i) {
+ if (i == l || ((b[i]>>2&3) == 0 && s >= 0)) {
+ if (s >= 0) {
+ int j;
+ printf("%s:%d-%d\t0\t%s\t%d\t60\t%dM\t*\t0\t0\t", h->target_name[tid], s+1, i, h->target_name[tid], s+1, i-s);
+ for (j = s; j < i; ++j) {
+ int c = cns[j]>>8;
+ if (c == 0) putchar('N');
+ else putchar("ACGT"[c&3]);
+ }
+ putchar('\t');
+ for (j = s; j < i; ++j)
+ putchar(33 + (cns[j]>>8>>2));
+ putchar('\n');
+ }
+ //if (s >= 0) printf("%s\t%d\t%d\t%d\n", h->target_name[tid], s, i, i - s);
+ s = -1;
+ } else if ((b[i]>>2&3) && s < 0) s = i;
+ }
+ free(b);
+}
+
+static int read_aln(void *data, bam1_t *b)
+{
+ extern int bam_prob_realn_core(bam1_t *b, const char *ref, int flag);
+ ct_t *g = (ct_t*)data;
+ int ret, len;
+ ret = bam_read1(g->fp, b);
+ if (ret >= 0 && g->fai && b->core.tid >= 0 && (b->core.flag&4) == 0) {
+ if (b->core.tid != g->tid) { // then load the sequence
+ free(g->ref);
+ g->ref = fai_fetch(g->fai, g->h->target_name[b->core.tid], &len);
+ g->tid = b->core.tid;
+ }
+ bam_prob_realn_core(b, g->ref, 1<<1|1);
+ }
+ return ret;
+}
+
+int main_cut_target(int argc, char *argv[])
+{
+ int c, tid, pos, n, lasttid = -1, lastpos = -1, l, max_l;
+ const bam_pileup1_t *p;
+ bam_plp_t plp;
+ uint16_t *cns;
+ ct_t g;
+
+ memset(&g, 0, sizeof(ct_t));
+ g.min_baseQ = 13; g.tid = -1;
+ while ((c = getopt(argc, argv, "f:Q:i:o:0:1:2:")) >= 0) {
+ switch (c) {
+ case 'Q': g.min_baseQ = atoi(optarg); break; // quality cutoff
+ case 'i': g_param.p[0][1] = -atoi(optarg); break; // 0->1 transition (in) PENALTY
+ case '0': g_param.e[1][0] = atoi(optarg); break; // emission SCORE
+ case '1': g_param.e[1][1] = atoi(optarg); break;
+ case '2': g_param.e[1][2] = atoi(optarg); break;
+ case 'f': g.fai = fai_load(optarg);
+ if (g.fai == 0) fprintf(pysamerr, "[%s] fail to load the fasta index.\n", __func__);
+ break;
+ }
+ }
+ if (argc == optind) {
+ fprintf(pysamerr, "Usage: samtools targetcut [-Q minQ] [-i inPen] [-0 em0] [-1 em1] [-2 em2] [-f ref] <in.bam>\n");
+ return 1;
+ }
+ l = max_l = 0; cns = 0;
+ g.fp = strcmp(argv[optind], "-")? bam_open(argv[optind], "r") : bam_dopen(fileno(stdin), "r");
+ g.h = bam_header_read(g.fp);
+ g.em = errmod_init(1 - ERR_DEP);
+ plp = bam_plp_init(read_aln, &g);
+ while ((p = bam_plp_auto(plp, &tid, &pos, &n)) != 0) {
+ if (tid < 0) break;
+ if (tid != lasttid) { // change of chromosome
+ if (cns) process_cns(g.h, lasttid, l, cns);
+ if (max_l < g.h->target_len[tid]) {
+ max_l = g.h->target_len[tid];
+ kroundup32(max_l);
+ cns = realloc(cns, max_l * 2);
+ }
+ l = g.h->target_len[tid];
+ memset(cns, 0, max_l * 2);
+ lasttid = tid;
+ }
+ cns[pos] = gencns(&g, n, p);
+ lastpos = pos;
+ }
+ process_cns(g.h, lasttid, l, cns);
+ free(cns);
+ bam_header_destroy(g.h);
+ bam_plp_destroy(plp);
+ bam_close(g.fp);
+ if (g.fai) {
+ fai_destroy(g.fai); free(g.ref);
+ }
+ errmod_destroy(g.em);
+ free(g.bases);
+ return 0;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <math.h>
+#include "errmod.h"
+#include "ksort.h"
+KSORT_INIT_GENERIC(uint16_t)
+
+typedef struct __errmod_coef_t {
+ double *fk, *beta, *lhet;
+} errmod_coef_t;
+
+typedef struct {
+ double fsum[16], bsum[16];
+ uint32_t c[16];
+} call_aux_t;
+
+static errmod_coef_t *cal_coef(double depcorr, double eta)
+{
+ int k, n, q;
+ long double sum, sum1;
+ double *lC;
+ errmod_coef_t *ec;
+
+ ec = calloc(1, sizeof(errmod_coef_t));
+ // initialize ->fk
+ ec->fk = (double*)calloc(256, sizeof(double));
+ ec->fk[0] = 1.0;
+ for (n = 1; n != 256; ++n)
+ ec->fk[n] = pow(1. - depcorr, n) * (1.0 - eta) + eta;
+ // initialize ->coef
+ ec->beta = (double*)calloc(256 * 256 * 64, sizeof(double));
+ lC = (double*)calloc(256 * 256, sizeof(double));
+ for (n = 1; n != 256; ++n) {
+ double lgn = lgamma(n+1);
+ for (k = 1; k <= n; ++k)
+ lC[n<<8|k] = lgn - lgamma(k+1) - lgamma(n-k+1);
+ }
+ for (q = 1; q != 64; ++q) {
+ double e = pow(10.0, -q/10.0);
+ double le = log(e);
+ double le1 = log(1.0 - e);
+ for (n = 1; n <= 255; ++n) {
+ double *beta = ec->beta + (q<<16|n<<8);
+ sum1 = sum = 0.0;
+ for (k = n; k >= 0; --k, sum1 = sum) {
+ sum = sum1 + expl(lC[n<<8|k] + k*le + (n-k)*le1);
+ beta[k] = -10. / M_LN10 * logl(sum1 / sum);
+ }
+ }
+ }
+ // initialize ->lhet
+ ec->lhet = (double*)calloc(256 * 256, sizeof(double));
+ for (n = 0; n < 256; ++n)
+ for (k = 0; k < 256; ++k)
+ ec->lhet[n<<8|k] = lC[n<<8|k] - M_LN2 * n;
+ free(lC);
+ return ec;
+}
+
+errmod_t *errmod_init(float depcorr)
+{
+ errmod_t *em;
+ em = (errmod_t*)calloc(1, sizeof(errmod_t));
+ em->depcorr = depcorr;
+ em->coef = cal_coef(depcorr, 0.03);
+ return em;
+}
+
+void errmod_destroy(errmod_t *em)
+{
+ if (em == 0) return;
+ free(em->coef->lhet); free(em->coef->fk); free(em->coef->beta);
+ free(em->coef); free(em);
+}
+// qual:6, strand:1, base:4
+int errmod_cal(const errmod_t *em, int n, int m, uint16_t *bases, float *q)
+{
+ call_aux_t aux;
+ int i, j, k, w[32];
+
+ if (m > m) return -1;
+ memset(q, 0, m * m * sizeof(float));
+ if (n == 0) return 0;
+ // calculate aux.esum and aux.fsum
+ if (n > 255) { // then sample 255 bases
+ ks_shuffle(uint16_t, n, bases);
+ n = 255;
+ }
+ ks_introsort(uint16_t, n, bases);
+ memset(w, 0, 32 * sizeof(int));
+ memset(&aux, 0, sizeof(call_aux_t));
+ for (j = n - 1; j >= 0; --j) { // calculate esum and fsum
+ uint16_t b = bases[j];
+ int q = b>>5 < 4? 4 : b>>5;
+ if (q > 63) q = 63;
+ k = b&0x1f;
+ aux.fsum[k&0xf] += em->coef->fk[w[k]];
+ aux.bsum[k&0xf] += em->coef->fk[w[k]] * em->coef->beta[q<<16|n<<8|aux.c[k&0xf]];
+ ++aux.c[k&0xf];
+ ++w[k];
+ }
+ // generate likelihood
+ for (j = 0; j != m; ++j) {
+ float tmp1, tmp3;
+ int tmp2, bar_e;
+ // homozygous
+ for (k = 0, tmp1 = tmp3 = 0.0, tmp2 = 0; k != m; ++k) {
+ if (k == j) continue;
+ tmp1 += aux.bsum[k]; tmp2 += aux.c[k]; tmp3 += aux.fsum[k];
+ }
+ if (tmp2) {
+ bar_e = (int)(tmp1 / tmp3 + 0.499);
+ if (bar_e > 63) bar_e = 63;
+ q[j*m+j] = tmp1;
+ }
+ // heterozygous
+ for (k = j + 1; k < m; ++k) {
+ int cjk = aux.c[j] + aux.c[k];
+ for (i = 0, tmp2 = 0, tmp1 = tmp3 = 0.0; i < m; ++i) {
+ if (i == j || i == k) continue;
+ tmp1 += aux.bsum[i]; tmp2 += aux.c[i]; tmp3 += aux.fsum[i];
+ }
+ if (tmp2) {
+ bar_e = (int)(tmp1 / tmp3 + 0.499);
+ if (bar_e > 63) bar_e = 63;
+ q[j*m+k] = q[k*m+j] = -4.343 * em->coef->lhet[cjk<<8|aux.c[k]] + tmp1;
+ } else q[j*m+k] = q[k*m+j] = -4.343 * em->coef->lhet[cjk<<8|aux.c[k]]; // all the bases are either j or k
+ }
+ for (k = 0; k != m; ++k) if (q[j*m+k] < 0.0) q[j*m+k] = 0.0;
+ }
+ return 0;
+}
--- /dev/null
+#ifndef ERRMOD_H
+#define ERRMOD_H
+
+#include <stdint.h>
+
+struct __errmod_coef_t;
+
+typedef struct {
+ double depcorr;
+ struct __errmod_coef_t *coef;
+} errmod_t;
+
+errmod_t *errmod_init(float depcorr);
+void errmod_destroy(errmod_t *em);
+
+/*
+ n: number of bases
+ m: maximum base
+ bases[i]: qual:6, strand:1, base:4
+ q[i*m+j]: phred-scaled likelihood of (i,j)
+ */
+int errmod_cal(const errmod_t *em, int n, int m, uint16_t *bases, float *q);
+
+#endif
+++ /dev/null
-#include <ctype.h>
-#include <string.h>
-#include <stdlib.h>
-#include <stdio.h>
-#include "faidx.h"
-#include "khash.h"
-
-typedef struct {
- uint64_t len:32, line_len:16, line_blen:16;
- uint64_t offset;
-} faidx1_t;
-KHASH_MAP_INIT_STR(s, faidx1_t)
-
-#ifndef _NO_RAZF
-#include "razf.h"
-#else
-#ifdef _WIN32
-#define ftello(fp) ftell(fp)
-#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
-#else
-extern off_t ftello(FILE *stream);
-extern int fseeko(FILE *stream, off_t offset, int whence);
-#endif
-#define RAZF FILE
-#define razf_read(fp, buf, size) fread(buf, 1, size, fp)
-#define razf_open(fn, mode) fopen(fn, mode)
-#define razf_close(fp) fclose(fp)
-#define razf_seek(fp, offset, whence) fseeko(fp, offset, whence)
-#define razf_tell(fp) ftello(fp)
-#endif
-#ifdef _USE_KNETFILE
-#include "knetfile.h"
-#endif
-
-struct __faidx_t {
- RAZF *rz;
- int n, m;
- char **name;
- khash_t(s) *hash;
-};
-
-#ifndef kroundup32
-#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x))
-#endif
-
-static inline void fai_insert_index(faidx_t *idx, const char *name, int len, int line_len, int line_blen, uint64_t offset)
-{
- khint_t k;
- int ret;
- faidx1_t t;
- if (idx->n == idx->m) {
- idx->m = idx->m? idx->m<<1 : 16;
- idx->name = (char**)realloc(idx->name, sizeof(void*) * idx->m);
- }
- idx->name[idx->n] = strdup(name);
- k = kh_put(s, idx->hash, idx->name[idx->n], &ret);
- t.len = len; t.line_len = line_len; t.line_blen = line_blen; t.offset = offset;
- kh_value(idx->hash, k) = t;
- ++idx->n;
-}
-
-faidx_t *fai_build_core(RAZF *rz)
-{
- char c, *name;
- int l_name, m_name, ret;
- int len, line_len, line_blen, state;
- int l1, l2;
- faidx_t *idx;
- uint64_t offset;
-
- idx = (faidx_t*)calloc(1, sizeof(faidx_t));
- idx->hash = kh_init(s);
- name = 0; l_name = m_name = 0;
- len = line_len = line_blen = -1; state = 0; l1 = l2 = -1; offset = 0;
- while (razf_read(rz, &c, 1)) {
- if (c == '\n') { // an empty line
- if (state == 1) {
- offset = razf_tell(rz);
- continue;
- } else if ((state == 0 && len < 0) || state == 2) continue;
- }
- if (c == '>') { // fasta header
- if (len >= 0)
- fai_insert_index(idx, name, len, line_len, line_blen, offset);
- l_name = 0;
- while ((ret = razf_read(rz, &c, 1)) != 0 && !isspace(c)) {
- if (m_name < l_name + 2) {
- m_name = l_name + 2;
- kroundup32(m_name);
- name = (char*)realloc(name, m_name);
- }
- name[l_name++] = c;
- }
- name[l_name] = '\0';
- if (ret == 0) {
- fprintf(stderr, "[fai_build_core] the last entry has no sequence\n");
- free(name); fai_destroy(idx);
- return 0;
- }
- if (c != '\n') while (razf_read(rz, &c, 1) && c != '\n');
- state = 1; len = 0;
- offset = razf_tell(rz);
- } else {
- if (state == 3) {
- fprintf(stderr, "[fai_build_core] inlined empty line is not allowed in sequence '%s'.\n", name);
- free(name); fai_destroy(idx);
- return 0;
- }
- if (state == 2) state = 3;
- l1 = l2 = 0;
- do {
- ++l1;
- if (isgraph(c)) ++l2;
- } while ((ret = razf_read(rz, &c, 1)) && c != '\n');
- if (state == 3 && l2) {
- fprintf(stderr, "[fai_build_core] different line length in sequence '%s'.\n", name);
- free(name); fai_destroy(idx);
- return 0;
- }
- ++l1; len += l2;
- if (l2 >= 0x10000) {
- fprintf(stderr, "[fai_build_core] line length exceeds 65535 in sequence '%s'.\n", name);
- free(name); fai_destroy(idx);
- return 0;
- }
- if (state == 1) line_len = l1, line_blen = l2, state = 0;
- else if (state == 0) {
- if (l1 != line_len || l2 != line_blen) state = 2;
- }
- }
- }
- fai_insert_index(idx, name, len, line_len, line_blen, offset);
- free(name);
- return idx;
-}
-
-void fai_save(const faidx_t *fai, FILE *fp)
-{
- khint_t k;
- int i;
- for (i = 0; i < fai->n; ++i) {
- faidx1_t x;
- k = kh_get(s, fai->hash, fai->name[i]);
- x = kh_value(fai->hash, k);
-#ifdef _WIN32
- fprintf(fp, "%s\t%d\t%ld\t%d\t%d\n", fai->name[i], (int)x.len, (long)x.offset, (int)x.line_blen, (int)x.line_len);
-#else
- fprintf(fp, "%s\t%d\t%lld\t%d\t%d\n", fai->name[i], (int)x.len, (long long)x.offset, (int)x.line_blen, (int)x.line_len);
-#endif
- }
-}
-
-faidx_t *fai_read(FILE *fp)
-{
- faidx_t *fai;
- char *buf, *p;
- int len, line_len, line_blen;
-#ifdef _WIN32
- long offset;
-#else
- long long offset;
-#endif
- fai = (faidx_t*)calloc(1, sizeof(faidx_t));
- fai->hash = kh_init(s);
- buf = (char*)calloc(0x10000, 1);
- while (!feof(fp) && fgets(buf, 0x10000, fp)) {
- for (p = buf; *p && isgraph(*p); ++p);
- *p = 0; ++p;
-#ifdef _WIN32
- sscanf(p, "%d%ld%d%d", &len, &offset, &line_blen, &line_len);
-#else
- sscanf(p, "%d%lld%d%d", &len, &offset, &line_blen, &line_len);
-#endif
- fai_insert_index(fai, buf, len, line_len, line_blen, offset);
- }
- free(buf);
- return fai;
-}
-
-void fai_destroy(faidx_t *fai)
-{
- int i;
- for (i = 0; i < fai->n; ++i) free(fai->name[i]);
- free(fai->name);
- kh_destroy(s, fai->hash);
- if (fai->rz) razf_close(fai->rz);
- free(fai);
-}
-
-int fai_build(const char *fn)
-{
- char *str;
- RAZF *rz;
- FILE *fp;
- faidx_t *fai;
- str = (char*)calloc(strlen(fn) + 5, 1);
- sprintf(str, "%s.fai", fn);
- rz = razf_open(fn, "r");
- if (rz == 0) {
- fprintf(stderr, "[fai_build] fail to open the FASTA file %s\n",fn);
- free(str);
- return -1;
- }
- fai = fai_build_core(rz);
- razf_close(rz);
- fp = fopen(str, "wb");
- if (fp == 0) {
- fprintf(stderr, "[fai_build] fail to write FASTA index %s\n",str);
- fai_destroy(fai); free(str);
- return -1;
- }
- fai_save(fai, fp);
- fclose(fp);
- free(str);
- fai_destroy(fai);
- return 0;
-}
-
-#ifdef _USE_KNETFILE
-FILE *download_and_open(const char *fn)
-{
- const int buf_size = 1 * 1024 * 1024;
- uint8_t *buf;
- FILE *fp;
- knetFile *fp_remote;
- const char *url = fn;
- const char *p;
- int l = strlen(fn);
- for (p = fn + l - 1; p >= fn; --p)
- if (*p == '/') break;
- fn = p + 1;
-
- // First try to open a local copy
- fp = fopen(fn, "r");
- if (fp)
- return fp;
-
- // If failed, download from remote and open
- fp_remote = knet_open(url, "rb");
- if (fp_remote == 0) {
- fprintf(stderr, "[download_from_remote] fail to open remote file %s\n",url);
- return NULL;
- }
- if ((fp = fopen(fn, "wb")) == 0) {
- fprintf(stderr, "[download_from_remote] fail to create file in the working directory %s\n",fn);
- knet_close(fp_remote);
- return NULL;
- }
- buf = (uint8_t*)calloc(buf_size, 1);
- while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
- fwrite(buf, 1, l, fp);
- free(buf);
- fclose(fp);
- knet_close(fp_remote);
-
- return fopen(fn, "r");
-}
-#endif
-
-faidx_t *fai_load(const char *fn)
-{
- char *str;
- FILE *fp;
- faidx_t *fai;
- str = (char*)calloc(strlen(fn) + 5, 1);
- sprintf(str, "%s.fai", fn);
-
-#ifdef _USE_KNETFILE
- if (strstr(fn, "ftp://") == fn || strstr(fn, "http://") == fn)
- {
- fp = download_and_open(str);
- if ( !fp )
- {
- fprintf(stderr, "[fai_load] failed to open remote FASTA index %s\n", str);
- free(str);
- return 0;
- }
- }
- else
-#endif
- fp = fopen(str, "rb");
- if (fp == 0) {
- fprintf(stderr, "[fai_load] build FASTA index.\n");
- fai_build(fn);
- fp = fopen(str, "rb");
- if (fp == 0) {
- fprintf(stderr, "[fai_load] fail to open FASTA index.\n");
- free(str);
- return 0;
- }
- }
-
- fai = fai_read(fp);
- fclose(fp);
-
- fai->rz = razf_open(fn, "rb");
- free(str);
- if (fai->rz == 0) {
- fprintf(stderr, "[fai_load] fail to open FASTA file.\n");
- return 0;
- }
- return fai;
-}
-
-char *fai_fetch(const faidx_t *fai, const char *str, int *len)
-{
- char *s, *p, c;
- int i, l, k;
- khiter_t iter;
- faidx1_t val;
- khash_t(s) *h;
- int beg, end;
-
- beg = end = -1;
- h = fai->hash;
- l = strlen(str);
- p = s = (char*)malloc(l+1);
- /* squeeze out "," */
- for (i = k = 0; i != l; ++i)
- if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
- s[k] = 0;
- for (i = 0; i != k; ++i) if (s[i] == ':') break;
- s[i] = 0;
- iter = kh_get(s, h, s); /* get the ref_id */
- if (iter == kh_end(h)) {
- *len = 0;
- free(s); return 0;
- }
- val = kh_value(h, iter);
- if (i == k) { /* dump the whole sequence */
- beg = 0; end = val.len;
- } else {
- for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
- beg = atoi(p);
- if (i < k) {
- p = s + i + 1;
- end = atoi(p);
- } else end = val.len;
- }
- if (beg > 0) --beg;
- if (beg >= val.len) beg = val.len;
- if (end >= val.len) end = val.len;
- if (beg > end) beg = end;
- free(s);
-
- // now retrieve the sequence
- l = 0;
- s = (char*)malloc(end - beg + 2);
- razf_seek(fai->rz, val.offset + beg / val.line_blen * val.line_len + beg % val.line_blen, SEEK_SET);
- while (razf_read(fai->rz, &c, 1) == 1 && l < end - beg && !fai->rz->z_err)
- if (isgraph(c)) s[l++] = c;
- s[l] = '\0';
- *len = l;
- return s;
-}
-
-int faidx_main(int argc, char *argv[])
-{
- if (argc == 1) {
- fprintf(stderr, "Usage: faidx <in.fasta> [<reg> [...]]\n");
- return 1;
- } else {
- if (argc == 2) fai_build(argv[1]);
- else {
- int i, j, k, l;
- char *s;
- faidx_t *fai;
- fai = fai_load(argv[1]);
- if (fai == 0) return 1;
- for (i = 2; i != argc; ++i) {
- printf(">%s\n", argv[i]);
- s = fai_fetch(fai, argv[i], &l);
- for (j = 0; j < l; j += 60) {
- for (k = 0; k < 60 && k < l - j; ++k)
- putchar(s[j + k]);
- putchar('\n');
- }
- free(s);
- }
- fai_destroy(fai);
- }
- }
- return 0;
-}
-
-int faidx_fetch_nseq(const faidx_t *fai)
-{
- return fai->n;
-}
-
-char *faidx_fetch_seq(const faidx_t *fai, char *c_name, int p_beg_i, int p_end_i, int *len)
-{
- int l;
- char c;
- khiter_t iter;
- faidx1_t val;
- char *seq=NULL;
-
- // Adjust position
- iter = kh_get(s, fai->hash, c_name);
- if(iter == kh_end(fai->hash)) return 0;
- val = kh_value(fai->hash, iter);
- if(p_end_i < p_beg_i) p_beg_i = p_end_i;
- if(p_beg_i < 0) p_beg_i = 0;
- else if(val.len <= p_beg_i) p_beg_i = val.len - 1;
- if(p_end_i < 0) p_end_i = 0;
- else if(val.len <= p_end_i) p_end_i = val.len - 1;
-
- // Now retrieve the sequence
- l = 0;
- seq = (char*)malloc(p_end_i - p_beg_i + 2);
- razf_seek(fai->rz, val.offset + p_beg_i / val.line_blen * val.line_len + p_beg_i % val.line_blen, SEEK_SET);
- while (razf_read(fai->rz, &c, 1) == 1 && l < p_end_i - p_beg_i + 1)
- if (isgraph(c)) seq[l++] = c;
- seq[l] = '\0';
- *len = l;
- return seq;
-}
-
-#ifdef FAIDX_MAIN
-int main(int argc, char *argv[]) { return faidx_main(argc, argv); }
-#endif
--- /dev/null
+#include "pysam.h"
+
+#include <ctype.h>
+#include <string.h>
+#include <stdlib.h>
+#include <stdio.h>
+#include <stdint.h>
+#include "faidx.h"
+#include "khash.h"
+
+typedef struct {
+ uint64_t len:32, line_len:16, line_blen:16;
+ uint64_t offset;
+} faidx1_t;
+KHASH_MAP_INIT_STR(s, faidx1_t)
+
+#ifndef _NO_RAZF
+#include "razf.h"
+#else
+#ifdef _WIN32
+#define ftello(fp) ftell(fp)
+#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
+#else
+extern off_t ftello(FILE *stream);
+extern int fseeko(FILE *stream, off_t offset, int whence);
+#endif
+#define RAZF FILE
+#define razf_read(fp, buf, size) fread(buf, 1, size, fp)
+#define razf_open(fn, mode) fopen(fn, mode)
+#define razf_close(fp) fclose(fp)
+#define razf_seek(fp, offset, whence) fseeko(fp, offset, whence)
+#define razf_tell(fp) ftello(fp)
+#endif
+#ifdef _USE_KNETFILE
+#include "knetfile.h"
+#endif
+
+struct __faidx_t {
+ RAZF *rz;
+ int n, m;
+ char **name;
+ khash_t(s) *hash;
+};
+
+#ifndef kroundup32
+#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x))
+#endif
+
+static inline void fai_insert_index(faidx_t *idx, const char *name, int len, int line_len, int line_blen, uint64_t offset)
+{
+ khint_t k;
+ int ret;
+ faidx1_t t;
+ if (idx->n == idx->m) {
+ idx->m = idx->m? idx->m<<1 : 16;
+ idx->name = (char**)realloc(idx->name, sizeof(void*) * idx->m);
+ }
+ idx->name[idx->n] = strdup(name);
+ k = kh_put(s, idx->hash, idx->name[idx->n], &ret);
+ t.len = len; t.line_len = line_len; t.line_blen = line_blen; t.offset = offset;
+ kh_value(idx->hash, k) = t;
+ ++idx->n;
+}
+
+faidx_t *fai_build_core(RAZF *rz)
+{
+ char c, *name;
+ int l_name, m_name, ret;
+ int len, line_len, line_blen, state;
+ int l1, l2;
+ faidx_t *idx;
+ uint64_t offset;
+
+ idx = (faidx_t*)calloc(1, sizeof(faidx_t));
+ idx->hash = kh_init(s);
+ name = 0; l_name = m_name = 0;
+ len = line_len = line_blen = -1; state = 0; l1 = l2 = -1; offset = 0;
+ while (razf_read(rz, &c, 1)) {
+ if (c == '\n') { // an empty line
+ if (state == 1) {
+ offset = razf_tell(rz);
+ continue;
+ } else if ((state == 0 && len < 0) || state == 2) continue;
+ }
+ if (c == '>') { // fasta header
+ if (len >= 0)
+ fai_insert_index(idx, name, len, line_len, line_blen, offset);
+ l_name = 0;
+ while ((ret = razf_read(rz, &c, 1)) != 0 && !isspace(c)) {
+ if (m_name < l_name + 2) {
+ m_name = l_name + 2;
+ kroundup32(m_name);
+ name = (char*)realloc(name, m_name);
+ }
+ name[l_name++] = c;
+ }
+ name[l_name] = '\0';
+ if (ret == 0) {
+ fprintf(pysamerr, "[fai_build_core] the last entry has no sequence\n");
+ free(name); fai_destroy(idx);
+ return 0;
+ }
+ if (c != '\n') while (razf_read(rz, &c, 1) && c != '\n');
+ state = 1; len = 0;
+ offset = razf_tell(rz);
+ } else {
+ if (state == 3) {
+ fprintf(pysamerr, "[fai_build_core] inlined empty line is not allowed in sequence '%s'.\n", name);
+ free(name); fai_destroy(idx);
+ return 0;
+ }
+ if (state == 2) state = 3;
+ l1 = l2 = 0;
+ do {
+ ++l1;
+ if (isgraph(c)) ++l2;
+ } while ((ret = razf_read(rz, &c, 1)) && c != '\n');
+ if (state == 3 && l2) {
+ fprintf(pysamerr, "[fai_build_core] different line length in sequence '%s'.\n", name);
+ free(name); fai_destroy(idx);
+ return 0;
+ }
+ ++l1; len += l2;
+ if (l2 >= 0x10000) {
+ fprintf(pysamerr, "[fai_build_core] line length exceeds 65535 in sequence '%s'.\n", name);
+ free(name); fai_destroy(idx);
+ return 0;
+ }
+ if (state == 1) line_len = l1, line_blen = l2, state = 0;
+ else if (state == 0) {
+ if (l1 != line_len || l2 != line_blen) state = 2;
+ }
+ }
+ }
+ fai_insert_index(idx, name, len, line_len, line_blen, offset);
+ free(name);
+ return idx;
+}
+
+void fai_save(const faidx_t *fai, FILE *fp)
+{
+ khint_t k;
+ int i;
+ for (i = 0; i < fai->n; ++i) {
+ faidx1_t x;
+ k = kh_get(s, fai->hash, fai->name[i]);
+ x = kh_value(fai->hash, k);
+#ifdef _WIN32
+ fprintf(fp, "%s\t%d\t%ld\t%d\t%d\n", fai->name[i], (int)x.len, (long)x.offset, (int)x.line_blen, (int)x.line_len);
+#else
+ fprintf(fp, "%s\t%d\t%lld\t%d\t%d\n", fai->name[i], (int)x.len, (long long)x.offset, (int)x.line_blen, (int)x.line_len);
+#endif
+ }
+}
+
+faidx_t *fai_read(FILE *fp)
+{
+ faidx_t *fai;
+ char *buf, *p;
+ int len, line_len, line_blen;
+#ifdef _WIN32
+ long offset;
+#else
+ long long offset;
+#endif
+ fai = (faidx_t*)calloc(1, sizeof(faidx_t));
+ fai->hash = kh_init(s);
+ buf = (char*)calloc(0x10000, 1);
+ while (!feof(fp) && fgets(buf, 0x10000, fp)) {
+ for (p = buf; *p && isgraph(*p); ++p);
+ *p = 0; ++p;
+#ifdef _WIN32
+ sscanf(p, "%d%ld%d%d", &len, &offset, &line_blen, &line_len);
+#else
+ sscanf(p, "%d%lld%d%d", &len, &offset, &line_blen, &line_len);
+#endif
+ fai_insert_index(fai, buf, len, line_len, line_blen, offset);
+ }
+ free(buf);
+ return fai;
+}
+
+void fai_destroy(faidx_t *fai)
+{
+ int i;
+ for (i = 0; i < fai->n; ++i) free(fai->name[i]);
+ free(fai->name);
+ kh_destroy(s, fai->hash);
+ if (fai->rz) razf_close(fai->rz);
+ free(fai);
+}
+
+int fai_build(const char *fn)
+{
+ char *str;
+ RAZF *rz;
+ FILE *fp;
+ faidx_t *fai;
+ str = (char*)calloc(strlen(fn) + 5, 1);
+ sprintf(str, "%s.fai", fn);
+ rz = razf_open(fn, "r");
+ if (rz == 0) {
+ fprintf(pysamerr, "[fai_build] fail to open the FASTA file %s\n",fn);
+ free(str);
+ return -1;
+ }
+ fai = fai_build_core(rz);
+ razf_close(rz);
+ fp = fopen(str, "wb");
+ if (fp == 0) {
+ fprintf(pysamerr, "[fai_build] fail to write FASTA index %s\n",str);
+ fai_destroy(fai); free(str);
+ return -1;
+ }
+ fai_save(fai, fp);
+ fclose(fp);
+ free(str);
+ fai_destroy(fai);
+ return 0;
+}
+
+#ifdef _USE_KNETFILE
+FILE *download_and_open(const char *fn)
+{
+ const int buf_size = 1 * 1024 * 1024;
+ uint8_t *buf;
+ FILE *fp;
+ knetFile *fp_remote;
+ const char *url = fn;
+ const char *p;
+ int l = strlen(fn);
+ for (p = fn + l - 1; p >= fn; --p)
+ if (*p == '/') break;
+ fn = p + 1;
+
+ // First try to open a local copy
+ fp = fopen(fn, "r");
+ if (fp)
+ return fp;
+
+ // If failed, download from remote and open
+ fp_remote = knet_open(url, "rb");
+ if (fp_remote == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to open remote file %s\n",url);
+ return NULL;
+ }
+ if ((fp = fopen(fn, "wb")) == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to create file in the working directory %s\n",fn);
+ knet_close(fp_remote);
+ return NULL;
+ }
+ buf = (uint8_t*)calloc(buf_size, 1);
+ while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
+ fwrite(buf, 1, l, fp);
+ free(buf);
+ fclose(fp);
+ knet_close(fp_remote);
+
+ return fopen(fn, "r");
+}
+#endif
+
+faidx_t *fai_load(const char *fn)
+{
+ char *str;
+ FILE *fp;
+ faidx_t *fai;
+ str = (char*)calloc(strlen(fn) + 5, 1);
+ sprintf(str, "%s.fai", fn);
+
+#ifdef _USE_KNETFILE
+ if (strstr(fn, "ftp://") == fn || strstr(fn, "http://") == fn)
+ {
+ fp = download_and_open(str);
+ if ( !fp )
+ {
+ fprintf(pysamerr, "[fai_load] failed to open remote FASTA index %s\n", str);
+ free(str);
+ return 0;
+ }
+ }
+ else
+#endif
+ fp = fopen(str, "rb");
+ if (fp == 0) {
+ fprintf(pysamerr, "[fai_load] build FASTA index.\n");
+ fai_build(fn);
+ fp = fopen(str, "rb");
+ if (fp == 0) {
+ fprintf(pysamerr, "[fai_load] fail to open FASTA index.\n");
+ free(str);
+ return 0;
+ }
+ }
+
+ fai = fai_read(fp);
+ fclose(fp);
+
+ fai->rz = razf_open(fn, "rb");
+ free(str);
+ if (fai->rz == 0) {
+ fprintf(pysamerr, "[fai_load] fail to open FASTA file.\n");
+ return 0;
+ }
+ return fai;
+}
+
+char *fai_fetch(const faidx_t *fai, const char *str, int *len)
+{
+ char *s, *p, c;
+ int i, l, k;
+ khiter_t iter;
+ faidx1_t val;
+ khash_t(s) *h;
+ int beg, end;
+
+ beg = end = -1;
+ h = fai->hash;
+ l = strlen(str);
+ p = s = (char*)malloc(l+1);
+ /* squeeze out "," */
+ for (i = k = 0; i != l; ++i)
+ if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
+ s[k] = 0;
+ for (i = 0; i != k; ++i) if (s[i] == ':') break;
+ s[i] = 0;
+ iter = kh_get(s, h, s); /* get the ref_id */
+ if (iter == kh_end(h)) {
+ *len = 0;
+ free(s); return 0;
+ }
+ val = kh_value(h, iter);
+ if (i == k) { /* dump the whole sequence */
+ beg = 0; end = val.len;
+ } else {
+ for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
+ beg = atoi(p);
+ if (i < k) {
+ p = s + i + 1;
+ end = atoi(p);
+ } else end = val.len;
+ }
+ if (beg > 0) --beg;
+ if (beg >= val.len) beg = val.len;
+ if (end >= val.len) end = val.len;
+ if (beg > end) beg = end;
+ free(s);
+
+ // now retrieve the sequence
+ l = 0;
+ s = (char*)malloc(end - beg + 2);
+ razf_seek(fai->rz, val.offset + beg / val.line_blen * val.line_len + beg % val.line_blen, SEEK_SET);
+ while (razf_read(fai->rz, &c, 1) == 1 && l < end - beg && !fai->rz->z_err)
+ if (isgraph(c)) s[l++] = c;
+ s[l] = '\0';
+ *len = l;
+ return s;
+}
+
+int faidx_main(int argc, char *argv[])
+{
+ if (argc == 1) {
+ fprintf(pysamerr, "Usage: faidx <in.fasta> [<reg> [...]]\n");
+ return 1;
+ } else {
+ if (argc == 2) fai_build(argv[1]);
+ else {
+ int i, j, k, l;
+ char *s;
+ faidx_t *fai;
+ fai = fai_load(argv[1]);
+ if (fai == 0) return 1;
+ for (i = 2; i != argc; ++i) {
+ printf(">%s\n", argv[i]);
+ s = fai_fetch(fai, argv[i], &l);
+ for (j = 0; j < l; j += 60) {
+ for (k = 0; k < 60 && k < l - j; ++k)
+ putchar(s[j + k]);
+ putchar('\n');
+ }
+ free(s);
+ }
+ fai_destroy(fai);
+ }
+ }
+ return 0;
+}
+
+int faidx_fetch_nseq(const faidx_t *fai)
+{
+ return fai->n;
+}
+
+char *faidx_fetch_seq(const faidx_t *fai, char *c_name, int p_beg_i, int p_end_i, int *len)
+{
+ int l;
+ char c;
+ khiter_t iter;
+ faidx1_t val;
+ char *seq=NULL;
+
+ // Adjust position
+ iter = kh_get(s, fai->hash, c_name);
+ if(iter == kh_end(fai->hash)) return 0;
+ val = kh_value(fai->hash, iter);
+ if(p_end_i < p_beg_i) p_beg_i = p_end_i;
+ if(p_beg_i < 0) p_beg_i = 0;
+ else if(val.len <= p_beg_i) p_beg_i = val.len - 1;
+ if(p_end_i < 0) p_end_i = 0;
+ else if(val.len <= p_end_i) p_end_i = val.len - 1;
+
+ // Now retrieve the sequence
+ l = 0;
+ seq = (char*)malloc(p_end_i - p_beg_i + 2);
+ razf_seek(fai->rz, val.offset + p_beg_i / val.line_blen * val.line_len + p_beg_i % val.line_blen, SEEK_SET);
+ while (razf_read(fai->rz, &c, 1) == 1 && l < p_end_i - p_beg_i + 1)
+ if (isgraph(c)) seq[l++] = c;
+ seq[l] = '\0';
+ *len = l;
+ return seq;
+}
+
+#ifdef FAIDX_MAIN
+int main(int argc, char *argv[]) { return faidx_main(argc, argv); }
+#endif
+++ /dev/null
-#include <string.h>
-#include <stdlib.h>
-#include "glf.h"
-
-#ifdef _NO_BGZF
-// then alias bgzf_*() functions
-#endif
-
-static int glf3_is_BE = 0;
-
-static inline uint32_t bam_swap_endian_4(uint32_t v)
-{
- v = ((v & 0x0000FFFFU) << 16) | (v >> 16);
- return ((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8);
-}
-
-static inline uint16_t bam_swap_endian_2(uint16_t v)
-{
- return (uint16_t)(((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8));
-}
-
-static inline int bam_is_big_endian()
-{
- long one= 1;
- return !(*((char *)(&one)));
-}
-
-glf3_header_t *glf3_header_init()
-{
- glf3_is_BE = bam_is_big_endian();
- return (glf3_header_t*)calloc(1, sizeof(glf3_header_t));
-}
-
-glf3_header_t *glf3_header_read(glfFile fp)
-{
- glf3_header_t *h;
- char magic[4];
- h = glf3_header_init();
- bgzf_read(fp, magic, 4);
- if (strncmp(magic, "GLF\3", 4)) {
- fprintf(stderr, "[glf3_header_read] invalid magic.\n");
- glf3_header_destroy(h);
- return 0;
- }
- bgzf_read(fp, &h->l_text, 4);
- if (glf3_is_BE) h->l_text = bam_swap_endian_4(h->l_text);
- if (h->l_text) {
- h->text = (uint8_t*)calloc(h->l_text + 1, 1);
- bgzf_read(fp, h->text, h->l_text);
- }
- return h;
-}
-
-void glf3_header_write(glfFile fp, const glf3_header_t *h)
-{
- int32_t x;
- bgzf_write(fp, "GLF\3", 4);
- x = glf3_is_BE? bam_swap_endian_4(h->l_text) : h->l_text;
- bgzf_write(fp, &x, 4);
- if (h->l_text) bgzf_write(fp, h->text, h->l_text);
-}
-
-void glf3_header_destroy(glf3_header_t *h)
-{
- free(h->text);
- free(h);
-}
-
-char *glf3_ref_read(glfFile fp, int *len)
-{
- int32_t n, x;
- char *str;
- *len = 0;
- if (bgzf_read(fp, &n, 4) != 4) return 0;
- if (glf3_is_BE) n = bam_swap_endian_4(n);
- if (n < 0) {
- fprintf(stderr, "[glf3_ref_read] invalid reference name length: %d.\n", n);
- return 0;
- }
- str = (char*)calloc(n + 1, 1); // not necesarily n+1 in fact
- x = bgzf_read(fp, str, n);
- x += bgzf_read(fp, len, 4);
- if (x != n + 4) {
- free(str); *len = -1; return 0; // truncated
- }
- if (glf3_is_BE) *len = bam_swap_endian_4(*len);
- return str;
-}
-
-void glf3_ref_write(glfFile fp, const char *str, int len)
-{
- int32_t m, n = strlen(str) + 1;
- m = glf3_is_BE? bam_swap_endian_4(n) : n;
- bgzf_write(fp, &m, 4);
- bgzf_write(fp, str, n);
- if (glf3_is_BE) len = bam_swap_endian_4(len);
- bgzf_write(fp, &len, 4);
-}
-
-void glf3_view1(const char *ref_name, const glf3_t *g3, int pos)
-{
- int j;
- if (g3->rtype == GLF3_RTYPE_END) return;
- printf("%s\t%d\t%c\t%d\t%d\t%d", ref_name, pos + 1,
- g3->rtype == GLF3_RTYPE_INDEL? '*' : "XACMGRSVTWYHKDBN"[g3->ref_base],
- g3->depth, g3->rms_mapQ, g3->min_lk);
- if (g3->rtype == GLF3_RTYPE_SUB)
- for (j = 0; j != 10; ++j) printf("\t%d", g3->lk[j]);
- else {
- printf("\t%d\t%d\t%d\t%d\t%d\t%s\t%s\t", g3->lk[0], g3->lk[1], g3->lk[2], g3->indel_len[0], g3->indel_len[1],
- g3->indel_len[0]? g3->indel_seq[0] : "*", g3->indel_len[1]? g3->indel_seq[1] : "*");
- }
- printf("\n");
-}
-
-int glf3_write1(glfFile fp, const glf3_t *g3)
-{
- int r;
- uint8_t c;
- uint32_t y[2];
- c = g3->rtype<<4 | g3->ref_base;
- r = bgzf_write(fp, &c, 1);
- if (g3->rtype == GLF3_RTYPE_END) return r;
- y[0] = g3->offset;
- y[1] = g3->min_lk<<24 | g3->depth;
- if (glf3_is_BE) {
- y[0] = bam_swap_endian_4(y[0]);
- y[1] = bam_swap_endian_4(y[1]);
- }
- r += bgzf_write(fp, y, 8);
- r += bgzf_write(fp, &g3->rms_mapQ, 1);
- if (g3->rtype == GLF3_RTYPE_SUB) r += bgzf_write(fp, g3->lk, 10);
- else {
- int16_t x[2];
- r += bgzf_write(fp, g3->lk, 3);
- x[0] = glf3_is_BE? bam_swap_endian_2(g3->indel_len[0]) : g3->indel_len[0];
- x[1] = glf3_is_BE? bam_swap_endian_2(g3->indel_len[1]) : g3->indel_len[1];
- r += bgzf_write(fp, x, 4);
- if (g3->indel_len[0]) r += bgzf_write(fp, g3->indel_seq[0], abs(g3->indel_len[0]));
- if (g3->indel_len[1]) r += bgzf_write(fp, g3->indel_seq[1], abs(g3->indel_len[1]));
- }
- return r;
-}
-
-#ifndef kv_roundup32
-#define kv_roundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x))
-#endif
-
-int glf3_read1(glfFile fp, glf3_t *g3)
-{
- int r;
- uint8_t c;
- uint32_t y[2];
- r = bgzf_read(fp, &c, 1);
- if (r == 0) return 0;
- g3->ref_base = c & 0xf;
- g3->rtype = c>>4;
- if (g3->rtype == GLF3_RTYPE_END) return r;
- r += bgzf_read(fp, y, 8);
- if (glf3_is_BE) {
- y[0] = bam_swap_endian_4(y[0]);
- y[1] = bam_swap_endian_4(y[1]);
- }
- g3->offset = y[0];
- g3->min_lk = y[1]>>24;
- g3->depth = y[1]<<8>>8;
- r += bgzf_read(fp, &g3->rms_mapQ, 1);
- if (g3->rtype == GLF3_RTYPE_SUB) r += bgzf_read(fp, g3->lk, 10);
- else {
- int16_t x[2], max;
- r += bgzf_read(fp, g3->lk, 3);
- r += bgzf_read(fp, x, 4);
- if (glf3_is_BE) {
- x[0] = bam_swap_endian_2(x[0]);
- x[1] = bam_swap_endian_2(x[1]);
- }
- g3->indel_len[0] = x[0];
- g3->indel_len[1] = x[1];
- x[0] = abs(x[0]); x[1] = abs(x[1]);
- max = (x[0] > x[1]? x[0] : x[1]) + 1;
- if (g3->max_len < max) {
- g3->max_len = max;
- kv_roundup32(g3->max_len);
- g3->indel_seq[0] = (char*)realloc(g3->indel_seq[0], g3->max_len);
- g3->indel_seq[1] = (char*)realloc(g3->indel_seq[1], g3->max_len);
- }
- r += bgzf_read(fp, g3->indel_seq[0], x[0]);
- r += bgzf_read(fp, g3->indel_seq[1], x[1]);
- g3->indel_seq[0][x[0]] = g3->indel_seq[1][x[1]] = 0;
- }
- return r;
-}
-
-void glf3_view(glfFile fp)
-{
- glf3_header_t *h;
- char *name;
- glf3_t *g3;
- int len;
- h = glf3_header_read(fp);
- g3 = glf3_init1();
- while ((name = glf3_ref_read(fp, &len)) != 0) {
- int pos = 0;
- while (glf3_read1(fp, g3) && g3->rtype != GLF3_RTYPE_END) {
- pos += g3->offset;
- glf3_view1(name, g3, pos);
- }
- free(name);
- }
- glf3_header_destroy(h);
- glf3_destroy1(g3);
-}
-
-int glf3_view_main(int argc, char *argv[])
-{
- glfFile fp;
- if (argc == 1) {
- fprintf(stderr, "Usage: glfview <in.glf>\n");
- return 1;
- }
- fp = (strcmp(argv[1], "-") == 0)? bgzf_fdopen(fileno(stdin), "r") : bgzf_open(argv[1], "r");
- if (fp == 0) {
- fprintf(stderr, "Fail to open file '%s'\n", argv[1]);
- return 1;
- }
- glf3_view(fp);
- bgzf_close(fp);
- return 0;
-}
-
-#ifdef GLFVIEW_MAIN
-int main(int argc, char *argv[])
-{
- return glf3_view_main(argc, argv);
-}
-#endif
--- /dev/null
+#include "pysam.h"
+
+#include <string.h>
+#include <stdlib.h>
+#include "glf.h"
+
+#ifdef _NO_BGZF
+// then alias bgzf_*() functions
+#endif
+
+static int glf3_is_BE = 0;
+
+static inline uint32_t bam_swap_endian_4(uint32_t v)
+{
+ v = ((v & 0x0000FFFFU) << 16) | (v >> 16);
+ return ((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8);
+}
+
+static inline uint16_t bam_swap_endian_2(uint16_t v)
+{
+ return (uint16_t)(((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8));
+}
+
+static inline int bam_is_big_endian()
+{
+ long one= 1;
+ return !(*((char *)(&one)));
+}
+
+glf3_header_t *glf3_header_init()
+{
+ glf3_is_BE = bam_is_big_endian();
+ return (glf3_header_t*)calloc(1, sizeof(glf3_header_t));
+}
+
+glf3_header_t *glf3_header_read(glfFile fp)
+{
+ glf3_header_t *h;
+ char magic[4];
+ h = glf3_header_init();
+ bgzf_read(fp, magic, 4);
+ if (strncmp(magic, "GLF\3", 4)) {
+ fprintf(pysamerr, "[glf3_header_read] invalid magic.\n");
+ glf3_header_destroy(h);
+ return 0;
+ }
+ bgzf_read(fp, &h->l_text, 4);
+ if (glf3_is_BE) h->l_text = bam_swap_endian_4(h->l_text);
+ if (h->l_text) {
+ h->text = (uint8_t*)calloc(h->l_text + 1, 1);
+ bgzf_read(fp, h->text, h->l_text);
+ }
+ return h;
+}
+
+void glf3_header_write(glfFile fp, const glf3_header_t *h)
+{
+ int32_t x;
+ bgzf_write(fp, "GLF\3", 4);
+ x = glf3_is_BE? bam_swap_endian_4(h->l_text) : h->l_text;
+ bgzf_write(fp, &x, 4);
+ if (h->l_text) bgzf_write(fp, h->text, h->l_text);
+}
+
+void glf3_header_destroy(glf3_header_t *h)
+{
+ free(h->text);
+ free(h);
+}
+
+char *glf3_ref_read(glfFile fp, int *len)
+{
+ int32_t n, x;
+ char *str;
+ *len = 0;
+ if (bgzf_read(fp, &n, 4) != 4) return 0;
+ if (glf3_is_BE) n = bam_swap_endian_4(n);
+ if (n < 0) {
+ fprintf(pysamerr, "[glf3_ref_read] invalid reference name length: %d.\n", n);
+ return 0;
+ }
+ str = (char*)calloc(n + 1, 1); // not necesarily n+1 in fact
+ x = bgzf_read(fp, str, n);
+ x += bgzf_read(fp, len, 4);
+ if (x != n + 4) {
+ free(str); *len = -1; return 0; // truncated
+ }
+ if (glf3_is_BE) *len = bam_swap_endian_4(*len);
+ return str;
+}
+
+void glf3_ref_write(glfFile fp, const char *str, int len)
+{
+ int32_t m, n = strlen(str) + 1;
+ m = glf3_is_BE? bam_swap_endian_4(n) : n;
+ bgzf_write(fp, &m, 4);
+ bgzf_write(fp, str, n);
+ if (glf3_is_BE) len = bam_swap_endian_4(len);
+ bgzf_write(fp, &len, 4);
+}
+
+void glf3_view1(const char *ref_name, const glf3_t *g3, int pos)
+{
+ int j;
+ if (g3->rtype == GLF3_RTYPE_END) return;
+ printf("%s\t%d\t%c\t%d\t%d\t%d", ref_name, pos + 1,
+ g3->rtype == GLF3_RTYPE_INDEL? '*' : "XACMGRSVTWYHKDBN"[g3->ref_base],
+ g3->depth, g3->rms_mapQ, g3->min_lk);
+ if (g3->rtype == GLF3_RTYPE_SUB)
+ for (j = 0; j != 10; ++j) printf("\t%d", g3->lk[j]);
+ else {
+ printf("\t%d\t%d\t%d\t%d\t%d\t%s\t%s\t", g3->lk[0], g3->lk[1], g3->lk[2], g3->indel_len[0], g3->indel_len[1],
+ g3->indel_len[0]? g3->indel_seq[0] : "*", g3->indel_len[1]? g3->indel_seq[1] : "*");
+ }
+ printf("\n");
+}
+
+int glf3_write1(glfFile fp, const glf3_t *g3)
+{
+ int r;
+ uint8_t c;
+ uint32_t y[2];
+ c = g3->rtype<<4 | g3->ref_base;
+ r = bgzf_write(fp, &c, 1);
+ if (g3->rtype == GLF3_RTYPE_END) return r;
+ y[0] = g3->offset;
+ y[1] = g3->min_lk<<24 | g3->depth;
+ if (glf3_is_BE) {
+ y[0] = bam_swap_endian_4(y[0]);
+ y[1] = bam_swap_endian_4(y[1]);
+ }
+ r += bgzf_write(fp, y, 8);
+ r += bgzf_write(fp, &g3->rms_mapQ, 1);
+ if (g3->rtype == GLF3_RTYPE_SUB) r += bgzf_write(fp, g3->lk, 10);
+ else {
+ int16_t x[2];
+ r += bgzf_write(fp, g3->lk, 3);
+ x[0] = glf3_is_BE? bam_swap_endian_2(g3->indel_len[0]) : g3->indel_len[0];
+ x[1] = glf3_is_BE? bam_swap_endian_2(g3->indel_len[1]) : g3->indel_len[1];
+ r += bgzf_write(fp, x, 4);
+ if (g3->indel_len[0]) r += bgzf_write(fp, g3->indel_seq[0], abs(g3->indel_len[0]));
+ if (g3->indel_len[1]) r += bgzf_write(fp, g3->indel_seq[1], abs(g3->indel_len[1]));
+ }
+ return r;
+}
+
+#ifndef kv_roundup32
+#define kv_roundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x))
+#endif
+
+int glf3_read1(glfFile fp, glf3_t *g3)
+{
+ int r;
+ uint8_t c;
+ uint32_t y[2];
+ r = bgzf_read(fp, &c, 1);
+ if (r == 0) return 0;
+ g3->ref_base = c & 0xf;
+ g3->rtype = c>>4;
+ if (g3->rtype == GLF3_RTYPE_END) return r;
+ r += bgzf_read(fp, y, 8);
+ if (glf3_is_BE) {
+ y[0] = bam_swap_endian_4(y[0]);
+ y[1] = bam_swap_endian_4(y[1]);
+ }
+ g3->offset = y[0];
+ g3->min_lk = y[1]>>24;
+ g3->depth = y[1]<<8>>8;
+ r += bgzf_read(fp, &g3->rms_mapQ, 1);
+ if (g3->rtype == GLF3_RTYPE_SUB) r += bgzf_read(fp, g3->lk, 10);
+ else {
+ int16_t x[2], max;
+ r += bgzf_read(fp, g3->lk, 3);
+ r += bgzf_read(fp, x, 4);
+ if (glf3_is_BE) {
+ x[0] = bam_swap_endian_2(x[0]);
+ x[1] = bam_swap_endian_2(x[1]);
+ }
+ g3->indel_len[0] = x[0];
+ g3->indel_len[1] = x[1];
+ x[0] = abs(x[0]); x[1] = abs(x[1]);
+ max = (x[0] > x[1]? x[0] : x[1]) + 1;
+ if (g3->max_len < max) {
+ g3->max_len = max;
+ kv_roundup32(g3->max_len);
+ g3->indel_seq[0] = (char*)realloc(g3->indel_seq[0], g3->max_len);
+ g3->indel_seq[1] = (char*)realloc(g3->indel_seq[1], g3->max_len);
+ }
+ r += bgzf_read(fp, g3->indel_seq[0], x[0]);
+ r += bgzf_read(fp, g3->indel_seq[1], x[1]);
+ g3->indel_seq[0][x[0]] = g3->indel_seq[1][x[1]] = 0;
+ }
+ return r;
+}
+
+void glf3_view(glfFile fp)
+{
+ glf3_header_t *h;
+ char *name;
+ glf3_t *g3;
+ int len;
+ h = glf3_header_read(fp);
+ g3 = glf3_init1();
+ while ((name = glf3_ref_read(fp, &len)) != 0) {
+ int pos = 0;
+ while (glf3_read1(fp, g3) && g3->rtype != GLF3_RTYPE_END) {
+ pos += g3->offset;
+ glf3_view1(name, g3, pos);
+ }
+ free(name);
+ }
+ glf3_header_destroy(h);
+ glf3_destroy1(g3);
+}
+
+int glf3_view_main(int argc, char *argv[])
+{
+ glfFile fp;
+ if (argc == 1) {
+ fprintf(pysamerr, "Usage: glfview <in.glf>\n");
+ return 1;
+ }
+ fp = (strcmp(argv[1], "-") == 0)? bgzf_fdopen(fileno(stdin), "r") : bgzf_open(argv[1], "r");
+ if (fp == 0) {
+ fprintf(pysamerr, "Fail to open file '%s'\n", argv[1]);
+ return 1;
+ }
+ glf3_view(fp);
+ bgzf_close(fp);
+ return 0;
+}
+
+#ifdef GLFVIEW_MAIN
+int main(int argc, char *argv[])
+{
+ return glf3_view_main(argc, argv);
+}
+#endif
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2003-2006, 2008, 2009, by Heng Li <lh3lh3@gmail.com>
-
- Permission is hereby granted, free of charge, to any person obtaining
- a copy of this software and associated documentation files (the
- "Software"), to deal in the Software without restriction, including
- without limitation the rights to use, copy, modify, merge, publish,
- distribute, sublicense, and/or sell copies of the Software, and to
- permit persons to whom the Software is furnished to do so, subject to
- the following conditions:
-
- The above copyright notice and this permission notice shall be
- included in all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
- EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
- MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
- NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
- BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
- ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
- CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
- SOFTWARE.
-*/
-
-#include <stdlib.h>
-#include <stdio.h>
-#include <string.h>
-#include <stdint.h>
-#include "kaln.h"
-
-#define FROM_M 0
-#define FROM_I 1
-#define FROM_D 2
-
-typedef struct {
- int i, j;
- unsigned char ctype;
-} path_t;
-
-int aln_sm_blosum62[] = {
-/* A R N D C Q E G H I L K M F P S T W Y V * X */
- 4,-1,-2,-2, 0,-1,-1, 0,-2,-1,-1,-1,-1,-2,-1, 1, 0,-3,-2, 0,-4, 0,
- -1, 5, 0,-2,-3, 1, 0,-2, 0,-3,-2, 2,-1,-3,-2,-1,-1,-3,-2,-3,-4,-1,
- -2, 0, 6, 1,-3, 0, 0, 0, 1,-3,-3, 0,-2,-3,-2, 1, 0,-4,-2,-3,-4,-1,
- -2,-2, 1, 6,-3, 0, 2,-1,-1,-3,-4,-1,-3,-3,-1, 0,-1,-4,-3,-3,-4,-1,
- 0,-3,-3,-3, 9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-4,-2,
- -1, 1, 0, 0,-3, 5, 2,-2, 0,-3,-2, 1, 0,-3,-1, 0,-1,-2,-1,-2,-4,-1,
- -1, 0, 0, 2,-4, 2, 5,-2, 0,-3,-3, 1,-2,-3,-1, 0,-1,-3,-2,-2,-4,-1,
- 0,-2, 0,-1,-3,-2,-2, 6,-2,-4,-4,-2,-3,-3,-2, 0,-2,-2,-3,-3,-4,-1,
- -2, 0, 1,-1,-3, 0, 0,-2, 8,-3,-3,-1,-2,-1,-2,-1,-2,-2, 2,-3,-4,-1,
- -1,-3,-3,-3,-1,-3,-3,-4,-3, 4, 2,-3, 1, 0,-3,-2,-1,-3,-1, 3,-4,-1,
- -1,-2,-3,-4,-1,-2,-3,-4,-3, 2, 4,-2, 2, 0,-3,-2,-1,-2,-1, 1,-4,-1,
- -1, 2, 0,-1,-3, 1, 1,-2,-1,-3,-2, 5,-1,-3,-1, 0,-1,-3,-2,-2,-4,-1,
- -1,-1,-2,-3,-1, 0,-2,-3,-2, 1, 2,-1, 5, 0,-2,-1,-1,-1,-1, 1,-4,-1,
- -2,-3,-3,-3,-2,-3,-3,-3,-1, 0, 0,-3, 0, 6,-4,-2,-2, 1, 3,-1,-4,-1,
- -1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4, 7,-1,-1,-4,-3,-2,-4,-2,
- 1,-1, 1, 0,-1, 0, 0, 0,-1,-2,-2, 0,-1,-2,-1, 4, 1,-3,-2,-2,-4, 0,
- 0,-1, 0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1, 1, 5,-2,-2, 0,-4, 0,
- -3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1, 1,-4,-3,-2,11, 2,-3,-4,-2,
- -2,-2,-2,-3,-2,-1,-2,-3, 2,-1,-1,-2,-1, 3,-3,-2,-2, 2, 7,-1,-4,-1,
- 0,-3,-3,-3,-1,-2,-2,-3,-3, 3, 1,-2, 1,-1,-2,-2, 0,-3,-1, 4,-4,-1,
- -4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4, 1,-4,
- 0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2, 0, 0,-2,-1,-1,-4,-1
-};
-
-int aln_sm_blast[] = {
- 1, -3, -3, -3, -2,
- -3, 1, -3, -3, -2,
- -3, -3, 1, -3, -2,
- -3, -3, -3, 1, -2,
- -2, -2, -2, -2, -2
-};
-
-ka_param_t ka_param_blast = { 5, 2, 2, aln_sm_blast, 5, 50 };
-ka_param_t ka_param_aa2aa = { 10, 2, 2, aln_sm_blosum62, 22, 50 };
-
-static uint32_t *ka_path2cigar32(const path_t *path, int path_len, int *n_cigar)
-{
- int i, n;
- uint32_t *cigar;
- unsigned char last_type;
-
- if (path_len == 0 || path == 0) {
- *n_cigar = 0;
- return 0;
- }
-
- last_type = path->ctype;
- for (i = n = 1; i < path_len; ++i) {
- if (last_type != path[i].ctype) ++n;
- last_type = path[i].ctype;
- }
- *n_cigar = n;
- cigar = (uint32_t*)calloc(*n_cigar, 4);
-
- cigar[0] = 1u << 4 | path[path_len-1].ctype;
- last_type = path[path_len-1].ctype;
- for (i = path_len - 2, n = 0; i >= 0; --i) {
- if (path[i].ctype == last_type) cigar[n] += 1u << 4;
- else {
- cigar[++n] = 1u << 4 | path[i].ctype;
- last_type = path[i].ctype;
- }
- }
-
- return cigar;
-}
-
-/***************************/
-/* START OF common_align.c */
-/***************************/
-
-#define SET_INF(s) (s).M = (s).I = (s).D = MINOR_INF;
-
-#define set_M(MM, cur, p, sc) \
-{ \
- if ((p)->M >= (p)->I) { \
- if ((p)->M >= (p)->D) { \
- (MM) = (p)->M + (sc); (cur)->Mt = FROM_M; \
- } else { \
- (MM) = (p)->D + (sc); (cur)->Mt = FROM_D; \
- } \
- } else { \
- if ((p)->I > (p)->D) { \
- (MM) = (p)->I + (sc); (cur)->Mt = FROM_I; \
- } else { \
- (MM) = (p)->D + (sc); (cur)->Mt = FROM_D; \
- } \
- } \
-}
-#define set_I(II, cur, p) \
-{ \
- if ((p)->M - gap_open > (p)->I) { \
- (cur)->It = FROM_M; \
- (II) = (p)->M - gap_open - gap_ext; \
- } else { \
- (cur)->It = FROM_I; \
- (II) = (p)->I - gap_ext; \
- } \
-}
-#define set_end_I(II, cur, p) \
-{ \
- if (gap_end >= 0) { \
- if ((p)->M - gap_open > (p)->I) { \
- (cur)->It = FROM_M; \
- (II) = (p)->M - gap_open - gap_end; \
- } else { \
- (cur)->It = FROM_I; \
- (II) = (p)->I - gap_end; \
- } \
- } else set_I(II, cur, p); \
-}
-#define set_D(DD, cur, p) \
-{ \
- if ((p)->M - gap_open > (p)->D) { \
- (cur)->Dt = FROM_M; \
- (DD) = (p)->M - gap_open - gap_ext; \
- } else { \
- (cur)->Dt = FROM_D; \
- (DD) = (p)->D - gap_ext; \
- } \
-}
-#define set_end_D(DD, cur, p) \
-{ \
- if (gap_end >= 0) { \
- if ((p)->M - gap_open > (p)->D) { \
- (cur)->Dt = FROM_M; \
- (DD) = (p)->M - gap_open - gap_end; \
- } else { \
- (cur)->Dt = FROM_D; \
- (DD) = (p)->D - gap_end; \
- } \
- } else set_D(DD, cur, p); \
-}
-
-typedef struct {
- uint8_t Mt:3, It:2, Dt:2;
-} dpcell_t;
-
-typedef struct {
- int M, I, D;
-} dpscore_t;
-
-/***************************
- * banded global alignment *
- ***************************/
-uint32_t *ka_global_core(uint8_t *seq1, int len1, uint8_t *seq2, int len2, const ka_param_t *ap, int *_score, int *n_cigar)
-{
- int i, j;
- dpcell_t **dpcell, *q;
- dpscore_t *curr, *last, *s;
- int b1, b2, tmp_end;
- int *mat, end, max = 0;
- uint8_t type, ctype;
- uint32_t *cigar = 0;
-
- int gap_open, gap_ext, gap_end, b;
- int *score_matrix, N_MATRIX_ROW;
-
- /* initialize some align-related parameters. just for compatibility */
- gap_open = ap->gap_open;
- gap_ext = ap->gap_ext;
- gap_end = ap->gap_end;
- b = ap->band_width;
- score_matrix = ap->matrix;
- N_MATRIX_ROW = ap->row;
-
- *n_cigar = 0;
- if (len1 == 0 || len2 == 0) return 0;
-
- /* calculate b1 and b2 */
- if (len1 > len2) {
- b1 = len1 - len2 + b;
- b2 = b;
- } else {
- b1 = b;
- b2 = len2 - len1 + b;
- }
- if (b1 > len1) b1 = len1;
- if (b2 > len2) b2 = len2;
- --seq1; --seq2;
-
- /* allocate memory */
- end = (b1 + b2 <= len1)? (b1 + b2 + 1) : (len1 + 1);
- dpcell = (dpcell_t**)malloc(sizeof(dpcell_t*) * (len2 + 1));
- for (j = 0; j <= len2; ++j)
- dpcell[j] = (dpcell_t*)malloc(sizeof(dpcell_t) * end);
- for (j = b2 + 1; j <= len2; ++j)
- dpcell[j] -= j - b2;
- curr = (dpscore_t*)malloc(sizeof(dpscore_t) * (len1 + 1));
- last = (dpscore_t*)malloc(sizeof(dpscore_t) * (len1 + 1));
-
- /* set first row */
- SET_INF(*curr); curr->M = 0;
- for (i = 1, s = curr + 1; i < b1; ++i, ++s) {
- SET_INF(*s);
- set_end_D(s->D, dpcell[0] + i, s - 1);
- }
- s = curr; curr = last; last = s;
-
- /* core dynamic programming, part 1 */
- tmp_end = (b2 < len2)? b2 : len2 - 1;
- for (j = 1; j <= tmp_end; ++j) {
- q = dpcell[j]; s = curr; SET_INF(*s);
- set_end_I(s->I, q, last);
- end = (j + b1 <= len1 + 1)? (j + b1 - 1) : len1;
- mat = score_matrix + seq2[j] * N_MATRIX_ROW;
- ++s; ++q;
- for (i = 1; i != end; ++i, ++s, ++q) {
- set_M(s->M, q, last + i - 1, mat[seq1[i]]); /* this will change s->M ! */
- set_I(s->I, q, last + i);
- set_D(s->D, q, s - 1);
- }
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_D(s->D, q, s - 1);
- if (j + b1 - 1 > len1) { /* bug fixed, 040227 */
- set_end_I(s->I, q, last + i);
- } else s->I = MINOR_INF;
- s = curr; curr = last; last = s;
- }
- /* last row for part 1, use set_end_D() instead of set_D() */
- if (j == len2 && b2 != len2 - 1) {
- q = dpcell[j]; s = curr; SET_INF(*s);
- set_end_I(s->I, q, last);
- end = (j + b1 <= len1 + 1)? (j + b1 - 1) : len1;
- mat = score_matrix + seq2[j] * N_MATRIX_ROW;
- ++s; ++q;
- for (i = 1; i != end; ++i, ++s, ++q) {
- set_M(s->M, q, last + i - 1, mat[seq1[i]]); /* this will change s->M ! */
- set_I(s->I, q, last + i);
- set_end_D(s->D, q, s - 1);
- }
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_end_D(s->D, q, s - 1);
- if (j + b1 - 1 > len1) { /* bug fixed, 040227 */
- set_end_I(s->I, q, last + i);
- } else s->I = MINOR_INF;
- s = curr; curr = last; last = s;
- ++j;
- }
-
- /* core dynamic programming, part 2 */
- for (; j <= len2 - b2 + 1; ++j) {
- SET_INF(curr[j - b2]);
- mat = score_matrix + seq2[j] * N_MATRIX_ROW;
- end = j + b1 - 1;
- for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i != end; ++i, ++s, ++q) {
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_I(s->I, q, last + i);
- set_D(s->D, q, s - 1);
- }
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_D(s->D, q, s - 1);
- s->I = MINOR_INF;
- s = curr; curr = last; last = s;
- }
-
- /* core dynamic programming, part 3 */
- for (; j < len2; ++j) {
- SET_INF(curr[j - b2]);
- mat = score_matrix + seq2[j] * N_MATRIX_ROW;
- for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i < len1; ++i, ++s, ++q) {
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_I(s->I, q, last + i);
- set_D(s->D, q, s - 1);
- }
- set_M(s->M, q, last + len1 - 1, mat[seq1[i]]);
- set_end_I(s->I, q, last + i);
- set_D(s->D, q, s - 1);
- s = curr; curr = last; last = s;
- }
- /* last row */
- if (j == len2) {
- SET_INF(curr[j - b2]);
- mat = score_matrix + seq2[j] * N_MATRIX_ROW;
- for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i < len1; ++i, ++s, ++q) {
- set_M(s->M, q, last + i - 1, mat[seq1[i]]);
- set_I(s->I, q, last + i);
- set_end_D(s->D, q, s - 1);
- }
- set_M(s->M, q, last + len1 - 1, mat[seq1[i]]);
- set_end_I(s->I, q, last + i);
- set_end_D(s->D, q, s - 1);
- s = curr; curr = last; last = s;
- }
-
- *_score = last[len1].M;
- if (n_cigar) { /* backtrace */
- path_t *p, *path = (path_t*)malloc(sizeof(path_t) * (len1 + len2 + 2));
- i = len1; j = len2;
- q = dpcell[j] + i;
- s = last + len1;
- max = s->M; type = q->Mt; ctype = FROM_M;
- if (s->I > max) { max = s->I; type = q->It; ctype = FROM_I; }
- if (s->D > max) { max = s->D; type = q->Dt; ctype = FROM_D; }
-
- p = path;
- p->ctype = ctype; p->i = i; p->j = j; /* bug fixed 040408 */
- ++p;
- do {
- switch (ctype) {
- case FROM_M: --i; --j; break;
- case FROM_I: --j; break;
- case FROM_D: --i; break;
- }
- q = dpcell[j] + i;
- ctype = type;
- switch (type) {
- case FROM_M: type = q->Mt; break;
- case FROM_I: type = q->It; break;
- case FROM_D: type = q->Dt; break;
- }
- p->ctype = ctype; p->i = i; p->j = j;
- ++p;
- } while (i || j);
- cigar = ka_path2cigar32(path, p - path - 1, n_cigar);
- free(path);
- }
-
- /* free memory */
- for (j = b2 + 1; j <= len2; ++j)
- dpcell[j] += j - b2;
- for (j = 0; j <= len2; ++j)
- free(dpcell[j]);
- free(dpcell);
- free(curr); free(last);
-
- return cigar;
-}
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2003-2006, 2008, 2009, by Heng Li <lh3lh3@gmail.com>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+#include <stdlib.h>
+#include <stdio.h>
+#include <string.h>
+#include <stdint.h>
+#include <math.h>
+#include "kaln.h"
+
+#define FROM_M 0
+#define FROM_I 1
+#define FROM_D 2
+
+typedef struct {
+ int i, j;
+ unsigned char ctype;
+} path_t;
+
+int aln_sm_blosum62[] = {
+/* A R N D C Q E G H I L K M F P S T W Y V * X */
+ 4,-1,-2,-2, 0,-1,-1, 0,-2,-1,-1,-1,-1,-2,-1, 1, 0,-3,-2, 0,-4, 0,
+ -1, 5, 0,-2,-3, 1, 0,-2, 0,-3,-2, 2,-1,-3,-2,-1,-1,-3,-2,-3,-4,-1,
+ -2, 0, 6, 1,-3, 0, 0, 0, 1,-3,-3, 0,-2,-3,-2, 1, 0,-4,-2,-3,-4,-1,
+ -2,-2, 1, 6,-3, 0, 2,-1,-1,-3,-4,-1,-3,-3,-1, 0,-1,-4,-3,-3,-4,-1,
+ 0,-3,-3,-3, 9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-4,-2,
+ -1, 1, 0, 0,-3, 5, 2,-2, 0,-3,-2, 1, 0,-3,-1, 0,-1,-2,-1,-2,-4,-1,
+ -1, 0, 0, 2,-4, 2, 5,-2, 0,-3,-3, 1,-2,-3,-1, 0,-1,-3,-2,-2,-4,-1,
+ 0,-2, 0,-1,-3,-2,-2, 6,-2,-4,-4,-2,-3,-3,-2, 0,-2,-2,-3,-3,-4,-1,
+ -2, 0, 1,-1,-3, 0, 0,-2, 8,-3,-3,-1,-2,-1,-2,-1,-2,-2, 2,-3,-4,-1,
+ -1,-3,-3,-3,-1,-3,-3,-4,-3, 4, 2,-3, 1, 0,-3,-2,-1,-3,-1, 3,-4,-1,
+ -1,-2,-3,-4,-1,-2,-3,-4,-3, 2, 4,-2, 2, 0,-3,-2,-1,-2,-1, 1,-4,-1,
+ -1, 2, 0,-1,-3, 1, 1,-2,-1,-3,-2, 5,-1,-3,-1, 0,-1,-3,-2,-2,-4,-1,
+ -1,-1,-2,-3,-1, 0,-2,-3,-2, 1, 2,-1, 5, 0,-2,-1,-1,-1,-1, 1,-4,-1,
+ -2,-3,-3,-3,-2,-3,-3,-3,-1, 0, 0,-3, 0, 6,-4,-2,-2, 1, 3,-1,-4,-1,
+ -1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4, 7,-1,-1,-4,-3,-2,-4,-2,
+ 1,-1, 1, 0,-1, 0, 0, 0,-1,-2,-2, 0,-1,-2,-1, 4, 1,-3,-2,-2,-4, 0,
+ 0,-1, 0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1, 1, 5,-2,-2, 0,-4, 0,
+ -3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1, 1,-4,-3,-2,11, 2,-3,-4,-2,
+ -2,-2,-2,-3,-2,-1,-2,-3, 2,-1,-1,-2,-1, 3,-3,-2,-2, 2, 7,-1,-4,-1,
+ 0,-3,-3,-3,-1,-2,-2,-3,-3, 3, 1,-2, 1,-1,-2,-2, 0,-3,-1, 4,-4,-1,
+ -4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4, 1,-4,
+ 0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2, 0, 0,-2,-1,-1,-4,-1
+};
+
+int aln_sm_blast[] = {
+ 1, -3, -3, -3, -2,
+ -3, 1, -3, -3, -2,
+ -3, -3, 1, -3, -2,
+ -3, -3, -3, 1, -2,
+ -2, -2, -2, -2, -2
+};
+
+int aln_sm_qual[] = {
+ 0, -23, -23, -23, 0,
+ -23, 0, -23, -23, 0,
+ -23, -23, 0, -23, 0,
+ -23, -23, -23, 0, 0,
+ 0, 0, 0, 0, 0
+};
+
+ka_param_t ka_param_blast = { 5, 2, 5, 2, aln_sm_blast, 5, 50 };
+ka_param_t ka_param_aa2aa = { 10, 2, 10, 2, aln_sm_blosum62, 22, 50 };
+
+ka_param2_t ka_param2_qual = { 37, 11, 37, 11, 37, 11, 0, 0, aln_sm_qual, 5, 50 };
+
+static uint32_t *ka_path2cigar32(const path_t *path, int path_len, int *n_cigar)
+{
+ int i, n;
+ uint32_t *cigar;
+ unsigned char last_type;
+
+ if (path_len == 0 || path == 0) {
+ *n_cigar = 0;
+ return 0;
+ }
+
+ last_type = path->ctype;
+ for (i = n = 1; i < path_len; ++i) {
+ if (last_type != path[i].ctype) ++n;
+ last_type = path[i].ctype;
+ }
+ *n_cigar = n;
+ cigar = (uint32_t*)calloc(*n_cigar, 4);
+
+ cigar[0] = 1u << 4 | path[path_len-1].ctype;
+ last_type = path[path_len-1].ctype;
+ for (i = path_len - 2, n = 0; i >= 0; --i) {
+ if (path[i].ctype == last_type) cigar[n] += 1u << 4;
+ else {
+ cigar[++n] = 1u << 4 | path[i].ctype;
+ last_type = path[i].ctype;
+ }
+ }
+
+ return cigar;
+}
+
+/***************************/
+/* START OF common_align.c */
+/***************************/
+
+#define SET_INF(s) (s).M = (s).I = (s).D = MINOR_INF;
+
+#define set_M(MM, cur, p, sc) \
+{ \
+ if ((p)->M >= (p)->I) { \
+ if ((p)->M >= (p)->D) { \
+ (MM) = (p)->M + (sc); (cur)->Mt = FROM_M; \
+ } else { \
+ (MM) = (p)->D + (sc); (cur)->Mt = FROM_D; \
+ } \
+ } else { \
+ if ((p)->I > (p)->D) { \
+ (MM) = (p)->I + (sc); (cur)->Mt = FROM_I; \
+ } else { \
+ (MM) = (p)->D + (sc); (cur)->Mt = FROM_D; \
+ } \
+ } \
+}
+#define set_I(II, cur, p) \
+{ \
+ if ((p)->M - gap_open > (p)->I) { \
+ (cur)->It = FROM_M; \
+ (II) = (p)->M - gap_open - gap_ext; \
+ } else { \
+ (cur)->It = FROM_I; \
+ (II) = (p)->I - gap_ext; \
+ } \
+}
+#define set_end_I(II, cur, p) \
+{ \
+ if (gap_end_ext >= 0) { \
+ if ((p)->M - gap_end_open > (p)->I) { \
+ (cur)->It = FROM_M; \
+ (II) = (p)->M - gap_end_open - gap_end_ext; \
+ } else { \
+ (cur)->It = FROM_I; \
+ (II) = (p)->I - gap_end_ext; \
+ } \
+ } else set_I(II, cur, p); \
+}
+#define set_D(DD, cur, p) \
+{ \
+ if ((p)->M - gap_open > (p)->D) { \
+ (cur)->Dt = FROM_M; \
+ (DD) = (p)->M - gap_open - gap_ext; \
+ } else { \
+ (cur)->Dt = FROM_D; \
+ (DD) = (p)->D - gap_ext; \
+ } \
+}
+#define set_end_D(DD, cur, p) \
+{ \
+ if (gap_end_ext >= 0) { \
+ if ((p)->M - gap_end_open > (p)->D) { \
+ (cur)->Dt = FROM_M; \
+ (DD) = (p)->M - gap_end_open - gap_end_ext; \
+ } else { \
+ (cur)->Dt = FROM_D; \
+ (DD) = (p)->D - gap_end_ext; \
+ } \
+ } else set_D(DD, cur, p); \
+}
+
+typedef struct {
+ uint8_t Mt:3, It:2, Dt:3;
+} dpcell_t;
+
+typedef struct {
+ int M, I, D;
+} dpscore_t;
+
+/***************************
+ * banded global alignment *
+ ***************************/
+uint32_t *ka_global_core(uint8_t *seq1, int len1, uint8_t *seq2, int len2, const ka_param_t *ap, int *_score, int *n_cigar)
+{
+ int i, j;
+ dpcell_t **dpcell, *q;
+ dpscore_t *curr, *last, *s;
+ int b1, b2, tmp_end;
+ int *mat, end, max = 0;
+ uint8_t type, ctype;
+ uint32_t *cigar = 0;
+
+ int gap_open, gap_ext, gap_end_open, gap_end_ext, b;
+ int *score_matrix, N_MATRIX_ROW;
+
+ /* initialize some align-related parameters. just for compatibility */
+ gap_open = ap->gap_open;
+ gap_ext = ap->gap_ext;
+ gap_end_open = ap->gap_end_open;
+ gap_end_ext = ap->gap_end_ext;
+ b = ap->band_width;
+ score_matrix = ap->matrix;
+ N_MATRIX_ROW = ap->row;
+
+ if (n_cigar) *n_cigar = 0;
+ if (len1 == 0 || len2 == 0) return 0;
+
+ /* calculate b1 and b2 */
+ if (len1 > len2) {
+ b1 = len1 - len2 + b;
+ b2 = b;
+ } else {
+ b1 = b;
+ b2 = len2 - len1 + b;
+ }
+ if (b1 > len1) b1 = len1;
+ if (b2 > len2) b2 = len2;
+ --seq1; --seq2;
+
+ /* allocate memory */
+ end = (b1 + b2 <= len1)? (b1 + b2 + 1) : (len1 + 1);
+ dpcell = (dpcell_t**)malloc(sizeof(dpcell_t*) * (len2 + 1));
+ for (j = 0; j <= len2; ++j)
+ dpcell[j] = (dpcell_t*)malloc(sizeof(dpcell_t) * end);
+ for (j = b2 + 1; j <= len2; ++j)
+ dpcell[j] -= j - b2;
+ curr = (dpscore_t*)malloc(sizeof(dpscore_t) * (len1 + 1));
+ last = (dpscore_t*)malloc(sizeof(dpscore_t) * (len1 + 1));
+
+ /* set first row */
+ SET_INF(*curr); curr->M = 0;
+ for (i = 1, s = curr + 1; i < b1; ++i, ++s) {
+ SET_INF(*s);
+ set_end_D(s->D, dpcell[0] + i, s - 1);
+ }
+ s = curr; curr = last; last = s;
+
+ /* core dynamic programming, part 1 */
+ tmp_end = (b2 < len2)? b2 : len2 - 1;
+ for (j = 1; j <= tmp_end; ++j) {
+ q = dpcell[j]; s = curr; SET_INF(*s);
+ set_end_I(s->I, q, last);
+ end = (j + b1 <= len1 + 1)? (j + b1 - 1) : len1;
+ mat = score_matrix + seq2[j] * N_MATRIX_ROW;
+ ++s; ++q;
+ for (i = 1; i != end; ++i, ++s, ++q) {
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]); /* this will change s->M ! */
+ set_I(s->I, q, last + i);
+ set_D(s->D, q, s - 1);
+ }
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_D(s->D, q, s - 1);
+ if (j + b1 - 1 > len1) { /* bug fixed, 040227 */
+ set_end_I(s->I, q, last + i);
+ } else s->I = MINOR_INF;
+ s = curr; curr = last; last = s;
+ }
+ /* last row for part 1, use set_end_D() instead of set_D() */
+ if (j == len2 && b2 != len2 - 1) {
+ q = dpcell[j]; s = curr; SET_INF(*s);
+ set_end_I(s->I, q, last);
+ end = (j + b1 <= len1 + 1)? (j + b1 - 1) : len1;
+ mat = score_matrix + seq2[j] * N_MATRIX_ROW;
+ ++s; ++q;
+ for (i = 1; i != end; ++i, ++s, ++q) {
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]); /* this will change s->M ! */
+ set_I(s->I, q, last + i);
+ set_end_D(s->D, q, s - 1);
+ }
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_end_D(s->D, q, s - 1);
+ if (j + b1 - 1 > len1) { /* bug fixed, 040227 */
+ set_end_I(s->I, q, last + i);
+ } else s->I = MINOR_INF;
+ s = curr; curr = last; last = s;
+ ++j;
+ }
+
+ /* core dynamic programming, part 2 */
+ for (; j <= len2 - b2 + 1; ++j) {
+ SET_INF(curr[j - b2]);
+ mat = score_matrix + seq2[j] * N_MATRIX_ROW;
+ end = j + b1 - 1;
+ for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i != end; ++i, ++s, ++q) {
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_I(s->I, q, last + i);
+ set_D(s->D, q, s - 1);
+ }
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_D(s->D, q, s - 1);
+ s->I = MINOR_INF;
+ s = curr; curr = last; last = s;
+ }
+
+ /* core dynamic programming, part 3 */
+ for (; j < len2; ++j) {
+ SET_INF(curr[j - b2]);
+ mat = score_matrix + seq2[j] * N_MATRIX_ROW;
+ for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i < len1; ++i, ++s, ++q) {
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_I(s->I, q, last + i);
+ set_D(s->D, q, s - 1);
+ }
+ set_M(s->M, q, last + len1 - 1, mat[seq1[i]]);
+ set_end_I(s->I, q, last + i);
+ set_D(s->D, q, s - 1);
+ s = curr; curr = last; last = s;
+ }
+ /* last row */
+ if (j == len2) {
+ SET_INF(curr[j - b2]);
+ mat = score_matrix + seq2[j] * N_MATRIX_ROW;
+ for (i = j - b2 + 1, q = dpcell[j] + i, s = curr + i; i < len1; ++i, ++s, ++q) {
+ set_M(s->M, q, last + i - 1, mat[seq1[i]]);
+ set_I(s->I, q, last + i);
+ set_end_D(s->D, q, s - 1);
+ }
+ set_M(s->M, q, last + len1 - 1, mat[seq1[i]]);
+ set_end_I(s->I, q, last + i);
+ set_end_D(s->D, q, s - 1);
+ s = curr; curr = last; last = s;
+ }
+
+ *_score = last[len1].M;
+ if (n_cigar) { /* backtrace */
+ path_t *p, *path = (path_t*)malloc(sizeof(path_t) * (len1 + len2 + 2));
+ i = len1; j = len2;
+ q = dpcell[j] + i;
+ s = last + len1;
+ max = s->M; type = q->Mt; ctype = FROM_M;
+ if (s->I > max) { max = s->I; type = q->It; ctype = FROM_I; }
+ if (s->D > max) { max = s->D; type = q->Dt; ctype = FROM_D; }
+
+ p = path;
+ p->ctype = ctype; p->i = i; p->j = j; /* bug fixed 040408 */
+ ++p;
+ do {
+ switch (ctype) {
+ case FROM_M: --i; --j; break;
+ case FROM_I: --j; break;
+ case FROM_D: --i; break;
+ }
+ q = dpcell[j] + i;
+ ctype = type;
+ switch (type) {
+ case FROM_M: type = q->Mt; break;
+ case FROM_I: type = q->It; break;
+ case FROM_D: type = q->Dt; break;
+ }
+ p->ctype = ctype; p->i = i; p->j = j;
+ ++p;
+ } while (i || j);
+ cigar = ka_path2cigar32(path, p - path - 1, n_cigar);
+ free(path);
+ }
+
+ /* free memory */
+ for (j = b2 + 1; j <= len2; ++j)
+ dpcell[j] += j - b2;
+ for (j = 0; j <= len2; ++j)
+ free(dpcell[j]);
+ free(dpcell);
+ free(curr); free(last);
+
+ return cigar;
+}
+
+typedef struct {
+ int M, I, D;
+} score_aux_t;
+
+#define MINUS_INF -0x40000000
+
+// matrix: len2 rows and len1 columns
+int ka_global_score(const uint8_t *_seq1, int len1, const uint8_t *_seq2, int len2, const ka_param2_t *ap)
+{
+
+#define __score_aux(_p, _q0, _sc, _io, _ie, _do, _de) { \
+ int t1, t2; \
+ score_aux_t *_q; \
+ _q = _q0; \
+ _p->M = _q->M >= _q->I? _q->M : _q->I; \
+ _p->M = _p->M >= _q->D? _p->M : _q->D; \
+ _p->M += (_sc); \
+ ++_q; t1 = _q->M - _io - _ie; t2 = _q->I - _ie; _p->I = t1 >= t2? t1 : t2; \
+ _q = _p-1; t1 = _q->M - _do - _de; t2 = _q->D - _de; _p->D = t1 >= t2? t1 : t2; \
+ }
+
+ int i, j, bw, scmat_size = ap->row, *scmat = ap->matrix, ret;
+ const uint8_t *seq1, *seq2;
+ score_aux_t *curr, *last, *swap;
+ bw = abs(len1 - len2) + ap->band_width;
+ i = len1 > len2? len1 : len2;
+ if (bw > i + 1) bw = i + 1;
+ seq1 = _seq1 - 1; seq2 = _seq2 - 1;
+ curr = calloc(len1 + 2, sizeof(score_aux_t));
+ last = calloc(len1 + 2, sizeof(score_aux_t));
+ { // the zero-th row
+ int x, end = len1;
+ score_aux_t *p;
+ j = 0;
+ x = j + bw; end = len1 < x? len1 : x; // band end
+ p = curr;
+ p->M = 0; p->I = p->D = MINUS_INF;
+ for (i = 1, p = &curr[1]; i <= end; ++i, ++p)
+ p->M = p->I = MINUS_INF, p->D = -(ap->edo + ap->ede * i);
+ p->M = p->I = p->D = MINUS_INF;
+ swap = curr; curr = last; last = swap;
+ }
+ for (j = 1; j < len2; ++j) {
+ int x, beg = 0, end = len1, *scrow, col_end;
+ score_aux_t *p;
+ x = j - bw; beg = 0 > x? 0 : x; // band start
+ x = j + bw; end = len1 < x? len1 : x; // band end
+ if (beg == 0) { // from zero-th column
+ p = curr;
+ p->M = p->D = MINUS_INF; p->I = -(ap->eio + ap->eie * j);
+ ++beg; // then beg = 1
+ }
+ scrow = scmat + seq2[j] * scmat_size;
+ if (end == len1) col_end = 1, --end;
+ else col_end = 0;
+ for (i = beg, p = &curr[beg]; i <= end; ++i, ++p)
+ __score_aux(p, &last[i-1], scrow[(int)seq1[i]], ap->iio, ap->iie, ap->ido, ap->ide);
+ if (col_end) {
+ __score_aux(p, &last[i-1], scrow[(int)seq1[i]], ap->eio, ap->eie, ap->ido, ap->ide);
+ ++p;
+ }
+ p->M = p->I = p->D = MINUS_INF;
+// for (i = 0; i <= len1; ++i) printf("(%d,%d,%d) ", curr[i].M, curr[i].I, curr[i].D); putchar('\n');
+ swap = curr; curr = last; last = swap;
+ }
+ { // the last row
+ int x, beg = 0, *scrow;
+ score_aux_t *p;
+ j = len2;
+ x = j - bw; beg = 0 > x? 0 : x; // band start
+ if (beg == 0) { // from zero-th column
+ p = curr;
+ p->M = p->D = MINUS_INF; p->I = -(ap->eio + ap->eie * j);
+ ++beg; // then beg = 1
+ }
+ scrow = scmat + seq2[j] * scmat_size;
+ for (i = beg, p = &curr[beg]; i < len1; ++i, ++p)
+ __score_aux(p, &last[i-1], scrow[(int)seq1[i]], ap->iio, ap->iie, ap->edo, ap->ede);
+ __score_aux(p, &last[i-1], scrow[(int)seq1[i]], ap->eio, ap->eie, ap->edo, ap->ede);
+// for (i = 0; i <= len1; ++i) printf("(%d,%d,%d) ", curr[i].M, curr[i].I, curr[i].D); putchar('\n');
+ }
+ ret = curr[len1].M >= curr[len1].I? curr[len1].M : curr[len1].I;
+ ret = ret >= curr[len1].D? ret : curr[len1].D;
+ free(curr); free(last);
+ return ret;
+}
+
+#ifdef _MAIN
+int main(int argc, char *argv[])
+{
+// int len1 = 35, len2 = 35;
+// uint8_t *seq1 = (uint8_t*)"\0\0\3\3\2\0\0\0\1\0\2\1\2\1\3\2\3\3\3\0\2\3\2\1\1\3\3\3\2\3\3\1\0\0\1";
+// uint8_t *seq2 = (uint8_t*)"\0\0\3\3\2\0\0\0\1\0\2\1\2\1\3\2\3\3\3\0\2\3\2\1\1\3\3\3\2\3\3\1\0\1\0";
+ int len1 = 4, len2 = 4;
+ uint8_t *seq1 = (uint8_t*)"\1\0\0\1";
+ uint8_t *seq2 = (uint8_t*)"\1\0\1\0";
+ int sc;
+// ka_global_core(seq1, 2, seq2, 1, &ka_param_qual, &sc, 0);
+ sc = ka_global_score(seq1, len1, seq2, len2, &ka_param2_qual);
+ printf("%d\n", sc);
+ return 0;
+}
+#endif
typedef struct {
int gap_open;
int gap_ext;
- int gap_end;
+ int gap_end_open;
+ int gap_end_ext;
int *matrix;
int row;
int band_width;
} ka_param_t;
+typedef struct {
+ int iio, iie, ido, ide;
+ int eio, eie, edo, ede;
+ int *matrix;
+ int row;
+ int band_width;
+} ka_param2_t;
+
#ifdef __cplusplus
extern "C" {
#endif
- uint32_t *ka_global_core(uint8_t *seq1, int len1, uint8_t *seq2, int len2, const ka_param_t *ap, int *_score, int *n_cigar);
-
+ uint32_t *ka_global_core(uint8_t *seq1, int len1, uint8_t *seq2, int len2, const ka_param_t *ap,
+ int *_score, int *n_cigar);
+ int ka_global_score(const uint8_t *_seq1, int len1, const uint8_t *_seq2, int len2, const ka_param2_t *ap);
#ifdef __cplusplus
}
#endif
-extern ka_param_t ka_param_blast; /* = { 5, 2, 2, aln_sm_blast, 5, 50 }; */
+extern ka_param_t ka_param_blast; /* = { 5, 2, 5, 2, aln_sm_blast, 5, 50 }; */
+extern ka_param_t ka_param_qual; // only use this for global alignment!!!
+extern ka_param2_t ka_param2_qual; // only use this for global alignment!!!
#endif
/* The MIT License
- Copyright (c) 2008 Genome Research Ltd (GRL).
+ Copyright (c) 2008, 2009, 2011 by Attractive Chaos <attractor@live.co.uk>
Permission is hereby granted, free of charge, to any person obtaining
a copy of this software and associated documentation files (the
SOFTWARE.
*/
-/* Contact: Heng Li <lh3@sanger.ac.uk> */
-
/*
An example:
*/
/*
+ 2011-02-14 (0.2.5):
+
+ * Allow to declare global functions.
+
+ 2009-09-26 (0.2.4):
+
+ * Improve portability
+
2008-09-19 (0.2.3):
* Corrected the example
@copyright Heng Li
*/
-#define AC_VERSION_KHASH_H "0.2.2"
+#define AC_VERSION_KHASH_H "0.2.5"
-#include <stdint.h>
#include <stdlib.h>
#include <string.h>
+#include <limits.h>
+
+/* compipler specific configuration */
+
+#if UINT_MAX == 0xffffffffu
+typedef unsigned int khint32_t;
+#elif ULONG_MAX == 0xffffffffu
+typedef unsigned long khint32_t;
+#endif
+
+#if ULONG_MAX == ULLONG_MAX
+typedef unsigned long khint64_t;
+#else
+typedef unsigned long long khint64_t;
+#endif
+
+#ifdef _MSC_VER
+#define inline __inline
+#endif
-typedef uint32_t khint_t;
+typedef khint32_t khint_t;
typedef khint_t khiter_t;
#define __ac_HASH_PRIME_SIZE 32
-static const uint32_t __ac_prime_list[__ac_HASH_PRIME_SIZE] =
+static const khint32_t __ac_prime_list[__ac_HASH_PRIME_SIZE] =
{
0ul, 3ul, 11ul, 23ul, 53ul,
97ul, 193ul, 389ul, 769ul, 1543ul,
static const double __ac_HASH_UPPER = 0.77;
-#define KHASH_INIT(name, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \
+#define KHASH_DECLARE(name, khkey_t, khval_t) \
+ typedef struct { \
+ khint_t n_buckets, size, n_occupied, upper_bound; \
+ khint32_t *flags; \
+ khkey_t *keys; \
+ khval_t *vals; \
+ } kh_##name##_t; \
+ extern kh_##name##_t *kh_init_##name(); \
+ extern void kh_destroy_##name(kh_##name##_t *h); \
+ extern void kh_clear_##name(kh_##name##_t *h); \
+ extern khint_t kh_get_##name(const kh_##name##_t *h, khkey_t key); \
+ extern void kh_resize_##name(kh_##name##_t *h, khint_t new_n_buckets); \
+ extern khint_t kh_put_##name(kh_##name##_t *h, khkey_t key, int *ret); \
+ extern void kh_del_##name(kh_##name##_t *h, khint_t x);
+
+#define KHASH_INIT2(name, SCOPE, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \
typedef struct { \
khint_t n_buckets, size, n_occupied, upper_bound; \
- uint32_t *flags; \
+ khint32_t *flags; \
khkey_t *keys; \
khval_t *vals; \
} kh_##name##_t; \
- static inline kh_##name##_t *kh_init_##name() { \
+ SCOPE kh_##name##_t *kh_init_##name() { \
return (kh_##name##_t*)calloc(1, sizeof(kh_##name##_t)); \
} \
- static inline void kh_destroy_##name(kh_##name##_t *h) \
+ SCOPE void kh_destroy_##name(kh_##name##_t *h) \
{ \
if (h) { \
free(h->keys); free(h->flags); \
free(h); \
} \
} \
- static inline void kh_clear_##name(kh_##name##_t *h) \
+ SCOPE void kh_clear_##name(kh_##name##_t *h) \
{ \
if (h && h->flags) { \
- memset(h->flags, 0xaa, ((h->n_buckets>>4) + 1) * sizeof(uint32_t)); \
+ memset(h->flags, 0xaa, ((h->n_buckets>>4) + 1) * sizeof(khint32_t)); \
h->size = h->n_occupied = 0; \
} \
} \
- static inline khint_t kh_get_##name(const kh_##name##_t *h, khkey_t key) \
+ SCOPE khint_t kh_get_##name(const kh_##name##_t *h, khkey_t key) \
{ \
if (h->n_buckets) { \
khint_t inc, k, i, last; \
return __ac_iseither(h->flags, i)? h->n_buckets : i; \
} else return 0; \
} \
- static inline void kh_resize_##name(kh_##name##_t *h, khint_t new_n_buckets) \
+ SCOPE void kh_resize_##name(kh_##name##_t *h, khint_t new_n_buckets) \
{ \
- uint32_t *new_flags = 0; \
+ khint32_t *new_flags = 0; \
khint_t j = 1; \
{ \
khint_t t = __ac_HASH_PRIME_SIZE - 1; \
new_n_buckets = __ac_prime_list[t+1]; \
if (h->size >= (khint_t)(new_n_buckets * __ac_HASH_UPPER + 0.5)) j = 0; \
else { \
- new_flags = (uint32_t*)malloc(((new_n_buckets>>4) + 1) * sizeof(uint32_t)); \
- memset(new_flags, 0xaa, ((new_n_buckets>>4) + 1) * sizeof(uint32_t)); \
+ new_flags = (khint32_t*)malloc(((new_n_buckets>>4) + 1) * sizeof(khint32_t)); \
+ memset(new_flags, 0xaa, ((new_n_buckets>>4) + 1) * sizeof(khint32_t)); \
if (h->n_buckets < new_n_buckets) { \
h->keys = (khkey_t*)realloc(h->keys, new_n_buckets * sizeof(khkey_t)); \
if (kh_is_map) \
h->upper_bound = (khint_t)(h->n_buckets * __ac_HASH_UPPER + 0.5); \
} \
} \
- static inline khint_t kh_put_##name(kh_##name##_t *h, khkey_t key, int *ret) \
+ SCOPE khint_t kh_put_##name(kh_##name##_t *h, khkey_t key, int *ret) \
{ \
khint_t x; \
if (h->n_occupied >= h->upper_bound) { \
} else *ret = 0; \
return x; \
} \
- static inline void kh_del_##name(kh_##name##_t *h, khint_t x) \
+ SCOPE void kh_del_##name(kh_##name##_t *h, khint_t x) \
{ \
if (x != h->n_buckets && !__ac_iseither(h->flags, x)) { \
__ac_set_isdel_true(h->flags, x); \
} \
}
+#define KHASH_INIT(name, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal) \
+ KHASH_INIT2(name, static inline, khkey_t, khval_t, kh_is_map, __hash_func, __hash_equal)
+
/* --- BEGIN OF HASH FUNCTIONS --- */
/*! @function
@abstract Integer hash function
- @param key The integer [uint32_t]
+ @param key The integer [khint32_t]
@return The hash value [khint_t]
*/
-#define kh_int_hash_func(key) (uint32_t)(key)
+#define kh_int_hash_func(key) (khint32_t)(key)
/*! @function
@abstract Integer comparison function
*/
#define kh_int_hash_equal(a, b) ((a) == (b))
/*! @function
@abstract 64-bit integer hash function
- @param key The integer [uint64_t]
+ @param key The integer [khint64_t]
@return The hash value [khint_t]
*/
-#define kh_int64_hash_func(key) (uint32_t)((key)>>33^(key)^(key)<<11)
+#define kh_int64_hash_func(key) (khint32_t)((key)>>33^(key)^(key)<<11)
/*! @function
@abstract 64-bit integer comparison function
*/
@param name Name of the hash table [symbol]
*/
#define KHASH_SET_INIT_INT(name) \
- KHASH_INIT(name, uint32_t, char, 0, kh_int_hash_func, kh_int_hash_equal)
+ KHASH_INIT(name, khint32_t, char, 0, kh_int_hash_func, kh_int_hash_equal)
/*! @function
@abstract Instantiate a hash map containing integer keys
@param khval_t Type of values [type]
*/
#define KHASH_MAP_INIT_INT(name, khval_t) \
- KHASH_INIT(name, uint32_t, khval_t, 1, kh_int_hash_func, kh_int_hash_equal)
+ KHASH_INIT(name, khint32_t, khval_t, 1, kh_int_hash_func, kh_int_hash_equal)
/*! @function
@abstract Instantiate a hash map containing 64-bit integer keys
@param name Name of the hash table [symbol]
*/
#define KHASH_SET_INIT_INT64(name) \
- KHASH_INIT(name, uint64_t, char, 0, kh_int64_hash_func, kh_int64_hash_equal)
+ KHASH_INIT(name, khint64_t, char, 0, kh_int64_hash_func, kh_int64_hash_equal)
/*! @function
@abstract Instantiate a hash map containing 64-bit integer keys
@param khval_t Type of values [type]
*/
#define KHASH_MAP_INIT_INT64(name, khval_t) \
- KHASH_INIT(name, uint64_t, khval_t, 1, kh_int64_hash_func, kh_int64_hash_equal)
+ KHASH_INIT(name, khint64_t, khval_t, 1, kh_int64_hash_func, kh_int64_hash_equal)
typedef const char *kh_cstr_t;
/*! @function
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2008 Genome Research Ltd (GRL).
-
- Permission is hereby granted, free of charge, to any person obtaining
- a copy of this software and associated documentation files (the
- "Software"), to deal in the Software without restriction, including
- without limitation the rights to use, copy, modify, merge, publish,
- distribute, sublicense, and/or sell copies of the Software, and to
- permit persons to whom the Software is furnished to do so, subject to
- the following conditions:
-
- The above copyright notice and this permission notice shall be
- included in all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
- EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
- MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
- NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
- BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
- ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
- CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
- SOFTWARE.
-*/
-
-/* Contact: Heng Li <lh3@sanger.ac.uk> */
-
-/* Probably I will not do socket programming in the next few years and
- therefore I decide to heavily annotate this file, for Linux and
- Windows as well. -lh3 */
-
-#include <time.h>
-#include <stdio.h>
-#include <ctype.h>
-#include <stdlib.h>
-#include <string.h>
-#include <errno.h>
-#include <unistd.h>
-#include <sys/types.h>
-
-#ifndef _WIN32
-#include <netdb.h>
-#include <arpa/inet.h>
-#include <sys/socket.h>
-#endif
-
-#include "knetfile.h"
-
-/* In winsock.h, the type of a socket is SOCKET, which is: "typedef
- * u_int SOCKET". An invalid SOCKET is: "(SOCKET)(~0)", or signed
- * integer -1. In knetfile.c, I use "int" for socket type
- * throughout. This should be improved to avoid confusion.
- *
- * In Linux/Mac, recv() and read() do almost the same thing. You can see
- * in the header file that netread() is simply an alias of read(). In
- * Windows, however, they are different and using recv() is mandatory.
- */
-
-/* This function tests if the file handler is ready for reading (or
- * writing if is_read==0). */
-static int socket_wait(int fd, int is_read)
-{
- fd_set fds, *fdr = 0, *fdw = 0;
- struct timeval tv;
- int ret;
- tv.tv_sec = 5; tv.tv_usec = 0; // 5 seconds time out
- FD_ZERO(&fds);
- FD_SET(fd, &fds);
- if (is_read) fdr = &fds;
- else fdw = &fds;
- ret = select(fd+1, fdr, fdw, 0, &tv);
-#ifndef _WIN32
- if (ret == -1) perror("select");
-#else
- if (ret == 0)
- fprintf(stderr, "select time-out\n");
- else if (ret == SOCKET_ERROR)
- fprintf(stderr, "select: %d\n", WSAGetLastError());
-#endif
- return ret;
-}
-
-#ifndef _WIN32
-/* This function does not work with Windows due to the lack of
- * getaddrinfo() in winsock. It is addapted from an example in "Beej's
- * Guide to Network Programming" (http://beej.us/guide/bgnet/). */
-static int socket_connect(const char *host, const char *port)
-{
-#define __err_connect(func) do { perror(func); freeaddrinfo(res); return -1; } while (0)
-
- int on = 1, fd;
- struct linger lng = { 0, 0 };
- struct addrinfo hints, *res;
- memset(&hints, 0, sizeof(struct addrinfo));
- hints.ai_family = AF_UNSPEC;
- hints.ai_socktype = SOCK_STREAM;
- /* In Unix/Mac, getaddrinfo() is the most convenient way to get
- * server information. */
- if (getaddrinfo(host, port, &hints, &res) != 0) __err_connect("getaddrinfo");
- if ((fd = socket(res->ai_family, res->ai_socktype, res->ai_protocol)) == -1) __err_connect("socket");
- /* The following two setsockopt() are used by ftplib
- * (http://nbpfaus.net/~pfau/ftplib/). I am not sure if they
- * necessary. */
- if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &on, sizeof(on)) == -1) __err_connect("setsockopt");
- if (setsockopt(fd, SOL_SOCKET, SO_LINGER, &lng, sizeof(lng)) == -1) __err_connect("setsockopt");
- if (connect(fd, res->ai_addr, res->ai_addrlen) != 0) __err_connect("connect");
- freeaddrinfo(res);
- return fd;
-}
-#else
-/* MinGW's printf has problem with "%lld" */
-char *int64tostr(char *buf, int64_t x)
-{
- int cnt;
- int i = 0;
- do {
- buf[i++] = '0' + x % 10;
- x /= 10;
- } while (x);
- buf[i] = 0;
- for (cnt = i, i = 0; i < cnt/2; ++i) {
- int c = buf[i]; buf[i] = buf[cnt-i-1]; buf[cnt-i-1] = c;
- }
- return buf;
-}
-
-int64_t strtoint64(const char *buf)
-{
- int64_t x;
- for (x = 0; *buf != '\0'; ++buf)
- x = x * 10 + ((int64_t) *buf - 48);
- return x;
-}
-/* In windows, the first thing is to establish the TCP connection. */
-int knet_win32_init()
-{
- WSADATA wsaData;
- return WSAStartup(MAKEWORD(2, 2), &wsaData);
-}
-void knet_win32_destroy()
-{
- WSACleanup();
-}
-/* A slightly modfied version of the following function also works on
- * Mac (and presummably Linux). However, this function is not stable on
- * my Mac. It sometimes works fine but sometimes does not. Therefore for
- * non-Windows OS, I do not use this one. */
-static SOCKET socket_connect(const char *host, const char *port)
-{
-#define __err_connect(func) \
- do { \
- fprintf(stderr, "%s: %d\n", func, WSAGetLastError()); \
- return -1; \
- } while (0)
-
- int on = 1;
- SOCKET fd;
- struct linger lng = { 0, 0 };
- struct sockaddr_in server;
- struct hostent *hp = 0;
- // open socket
- if ((fd = socket(AF_INET, SOCK_STREAM, IPPROTO_TCP)) == INVALID_SOCKET) __err_connect("socket");
- if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, (char*)&on, sizeof(on)) == -1) __err_connect("setsockopt");
- if (setsockopt(fd, SOL_SOCKET, SO_LINGER, (char*)&lng, sizeof(lng)) == -1) __err_connect("setsockopt");
- // get host info
- if (isalpha(host[0])) hp = gethostbyname(host);
- else {
- struct in_addr addr;
- addr.s_addr = inet_addr(host);
- hp = gethostbyaddr((char*)&addr, 4, AF_INET);
- }
- if (hp == 0) __err_connect("gethost");
- // connect
- server.sin_addr.s_addr = *((unsigned long*)hp->h_addr);
- server.sin_family= AF_INET;
- server.sin_port = htons(atoi(port));
- if (connect(fd, (struct sockaddr*)&server, sizeof(server)) != 0) __err_connect("connect");
- // freehostent(hp); // strangely in MSDN, hp is NOT freed (memory leak?!)
- return fd;
-}
-#endif
-
-static off_t my_netread(int fd, void *buf, off_t len)
-{
- off_t rest = len, curr, l = 0;
- /* recv() and read() may not read the required length of data with
- * one call. They have to be called repeatedly. */
- while (rest) {
- if (socket_wait(fd, 1) <= 0) break; // socket is not ready for reading
- curr = netread(fd, buf + l, rest);
- /* According to the glibc manual, section 13.2, a zero returned
- * value indicates end-of-file (EOF), which should mean that
- * read() will not return zero if EOF has not been met but data
- * are not immediately available. */
- if (curr == 0) break;
- l += curr; rest -= curr;
- }
- return l;
-}
-
-/*************************
- * FTP specific routines *
- *************************/
-
-static int kftp_get_response(knetFile *ftp)
-{
-#ifndef _WIN32
- unsigned char c;
-#else
- char c;
-#endif
- int n = 0;
- char *p;
- if (socket_wait(ftp->ctrl_fd, 1) <= 0) return 0;
- while (netread(ftp->ctrl_fd, &c, 1)) { // FIXME: this is *VERY BAD* for unbuffered I/O
- //fputc(c, stderr);
- if (n >= ftp->max_response) {
- ftp->max_response = ftp->max_response? ftp->max_response<<1 : 256;
- ftp->response = realloc(ftp->response, ftp->max_response);
- }
- ftp->response[n++] = c;
- if (c == '\n') {
- if (n >= 4 && isdigit(ftp->response[0]) && isdigit(ftp->response[1]) && isdigit(ftp->response[2])
- && ftp->response[3] != '-') break;
- n = 0;
- continue;
- }
- }
- if (n < 2) return -1;
- ftp->response[n-2] = 0;
- return strtol(ftp->response, &p, 0);
-}
-
-static int kftp_send_cmd(knetFile *ftp, const char *cmd, int is_get)
-{
- if (socket_wait(ftp->ctrl_fd, 0) <= 0) return -1; // socket is not ready for writing
- netwrite(ftp->ctrl_fd, cmd, strlen(cmd));
- return is_get? kftp_get_response(ftp) : 0;
-}
-
-static int kftp_pasv_prep(knetFile *ftp)
-{
- char *p;
- int v[6];
- kftp_send_cmd(ftp, "PASV\r\n", 1);
- for (p = ftp->response; *p && *p != '('; ++p);
- if (*p != '(') return -1;
- ++p;
- sscanf(p, "%d,%d,%d,%d,%d,%d", &v[0], &v[1], &v[2], &v[3], &v[4], &v[5]);
- memcpy(ftp->pasv_ip, v, 4 * sizeof(int));
- ftp->pasv_port = (v[4]<<8&0xff00) + v[5];
- return 0;
-}
-
-
-static int kftp_pasv_connect(knetFile *ftp)
-{
- char host[80], port[10];
- if (ftp->pasv_port == 0) {
- fprintf(stderr, "[kftp_pasv_connect] kftp_pasv_prep() is not called before hand.\n");
- return -1;
- }
- sprintf(host, "%d.%d.%d.%d", ftp->pasv_ip[0], ftp->pasv_ip[1], ftp->pasv_ip[2], ftp->pasv_ip[3]);
- sprintf(port, "%d", ftp->pasv_port);
- ftp->fd = socket_connect(host, port);
- if (ftp->fd == -1) return -1;
- return 0;
-}
-
-int kftp_connect(knetFile *ftp)
-{
- ftp->ctrl_fd = socket_connect(ftp->host, ftp->port);
- if (ftp->ctrl_fd == -1) return -1;
- kftp_get_response(ftp);
- kftp_send_cmd(ftp, "USER anonymous\r\n", 1);
- kftp_send_cmd(ftp, "PASS kftp@\r\n", 1);
- kftp_send_cmd(ftp, "TYPE I\r\n", 1);
- return 0;
-}
-
-int kftp_reconnect(knetFile *ftp)
-{
- if (ftp->ctrl_fd != -1) {
- netclose(ftp->ctrl_fd);
- ftp->ctrl_fd = -1;
- }
- netclose(ftp->fd);
- ftp->fd = -1;
- return kftp_connect(ftp);
-}
-
-// initialize ->type, ->host, ->retr and ->size
-knetFile *kftp_parse_url(const char *fn, const char *mode)
-{
- knetFile *fp;
- char *p;
- int l;
- if (strstr(fn, "ftp://") != fn) return 0;
- for (p = (char*)fn + 6; *p && *p != '/'; ++p);
- if (*p != '/') return 0;
- l = p - fn - 6;
- fp = calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_FTP;
- fp->fd = -1;
- /* the Linux/Mac version of socket_connect() also recognizes a port
- * like "ftp", but the Windows version does not. */
- fp->port = strdup("21");
- fp->host = calloc(l + 1, 1);
- if (strchr(mode, 'c')) fp->no_reconnect = 1;
- strncpy(fp->host, fn + 6, l);
- fp->retr = calloc(strlen(p) + 8, 1);
- sprintf(fp->retr, "RETR %s\r\n", p);
- fp->size_cmd = calloc(strlen(p) + 8, 1);
- sprintf(fp->size_cmd, "SIZE %s\r\n", p);
- fp->seek_offset = 0;
- return fp;
-}
-// place ->fd at offset off
-int kftp_connect_file(knetFile *fp)
-{
- int ret;
- long long file_size;
- if (fp->fd != -1) {
- netclose(fp->fd);
- if (fp->no_reconnect) kftp_get_response(fp);
- }
- kftp_pasv_prep(fp);
- kftp_send_cmd(fp, fp->size_cmd, 1);
-#ifndef _WIN32
- if ( sscanf(fp->response,"%*d %lld", &file_size) != 1 )
- {
- fprintf(stderr,"[kftp_connect_file] %s\n", fp->response);
- return -1;
- }
-#else
- const char *p = fp->response;
- while (*p != ' ') ++p;
- while (*p < '0' || *p > '9') ++p;
- file_size = strtoint64(p);
-#endif
- fp->file_size = file_size;
- if (fp->offset>=0) {
- char tmp[32];
-#ifndef _WIN32
- sprintf(tmp, "REST %lld\r\n", (long long)fp->offset);
-#else
- strcpy(tmp, "REST ");
- int64tostr(tmp + 5, fp->offset);
- strcat(tmp, "\r\n");
-#endif
- kftp_send_cmd(fp, tmp, 1);
- }
- kftp_send_cmd(fp, fp->retr, 0);
- kftp_pasv_connect(fp);
- ret = kftp_get_response(fp);
- if (ret != 150) {
- fprintf(stderr, "[kftp_connect_file] %s\n", fp->response);
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- fp->is_ready = 1;
- return 0;
-}
-
-
-/**************************
- * HTTP specific routines *
- **************************/
-
-knetFile *khttp_parse_url(const char *fn, const char *mode)
-{
- knetFile *fp;
- char *p, *proxy, *q;
- int l;
- if (strstr(fn, "http://") != fn) return 0;
- // set ->http_host
- for (p = (char*)fn + 7; *p && *p != '/'; ++p);
- l = p - fn - 7;
- fp = calloc(1, sizeof(knetFile));
- fp->http_host = calloc(l + 1, 1);
- strncpy(fp->http_host, fn + 7, l);
- fp->http_host[l] = 0;
- for (q = fp->http_host; *q && *q != ':'; ++q);
- if (*q == ':') *q++ = 0;
- // get http_proxy
- proxy = getenv("http_proxy");
- // set ->host, ->port and ->path
- if (proxy == 0) {
- fp->host = strdup(fp->http_host); // when there is no proxy, server name is identical to http_host name.
- fp->port = strdup(*q? q : "80");
- fp->path = strdup(*p? p : "/");
- } else {
- fp->host = (strstr(proxy, "http://") == proxy)? strdup(proxy + 7) : strdup(proxy);
- for (q = fp->host; *q && *q != ':'; ++q);
- if (*q == ':') *q++ = 0;
- fp->port = strdup(*q? q : "80");
- fp->path = strdup(fn);
- }
- fp->type = KNF_TYPE_HTTP;
- fp->ctrl_fd = fp->fd = -1;
- fp->seek_offset = 0;
- return fp;
-}
-
-int khttp_connect_file(knetFile *fp)
-{
- int ret, l = 0;
- char *buf, *p;
- if (fp->fd != -1) netclose(fp->fd);
- fp->fd = socket_connect(fp->host, fp->port);
- buf = calloc(0x10000, 1); // FIXME: I am lazy... But in principle, 64KB should be large enough.
- l += sprintf(buf + l, "GET %s HTTP/1.0\r\nHost: %s\r\n", fp->path, fp->http_host);
- l += sprintf(buf + l, "Range: bytes=%lld-\r\n", (long long)fp->offset);
- l += sprintf(buf + l, "\r\n");
- netwrite(fp->fd, buf, l);
- l = 0;
- while (netread(fp->fd, buf + l, 1)) { // read HTTP header; FIXME: bad efficiency
- if (buf[l] == '\n' && l >= 3)
- if (strncmp(buf + l - 3, "\r\n\r\n", 4) == 0) break;
- ++l;
- }
- buf[l] = 0;
- if (l < 14) { // prematured header
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- ret = strtol(buf + 8, &p, 0); // HTTP return code
- if (ret == 200 && fp->offset>0) { // 200 (complete result); then skip beginning of the file
- off_t rest = fp->offset;
- while (rest) {
- off_t l = rest < 0x10000? rest : 0x10000;
- rest -= my_netread(fp->fd, buf, l);
- }
- } else if (ret != 206 && ret != 200) {
- free(buf);
- fprintf(stderr, "[khttp_connect_file] fail to open file (HTTP code: %d).\n", ret);
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- free(buf);
- fp->is_ready = 1;
- return 0;
-}
-
-/********************
- * Generic routines *
- ********************/
-
-knetFile *knet_open(const char *fn, const char *mode)
-{
- knetFile *fp = 0;
- if (mode[0] != 'r') {
- fprintf(stderr, "[kftp_open] only mode \"r\" is supported.\n");
- return 0;
- }
- if (strstr(fn, "ftp://") == fn) {
- fp = kftp_parse_url(fn, mode);
- if (fp == 0) return 0;
- if (kftp_connect(fp) == -1) {
- knet_close(fp);
- return 0;
- }
- kftp_connect_file(fp);
- } else if (strstr(fn, "http://") == fn) {
- fp = khttp_parse_url(fn, mode);
- if (fp == 0) return 0;
- khttp_connect_file(fp);
- } else { // local file
-#ifdef _WIN32
- /* In windows, O_BINARY is necessary. In Linux/Mac, O_BINARY may
- * be undefined on some systems, although it is defined on my
- * Mac and the Linux I have tested on. */
- int fd = open(fn, O_RDONLY | O_BINARY);
-#else
- int fd = open(fn, O_RDONLY);
-#endif
- if (fd == -1) {
- perror("open");
- return 0;
- }
- fp = (knetFile*)calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_LOCAL;
- fp->fd = fd;
- fp->ctrl_fd = -1;
- }
- if (fp && fp->fd == -1) {
- knet_close(fp);
- return 0;
- }
- return fp;
-}
-
-knetFile *knet_dopen(int fd, const char *mode)
-{
- knetFile *fp = (knetFile*)calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_LOCAL;
- fp->fd = fd;
- return fp;
-}
-
-off_t knet_read(knetFile *fp, void *buf, off_t len)
-{
- off_t l = 0;
- if (fp->fd == -1) return 0;
- if (fp->type == KNF_TYPE_FTP) {
- if (fp->is_ready == 0) {
- if (!fp->no_reconnect) kftp_reconnect(fp);
- kftp_connect_file(fp);
- }
- } else if (fp->type == KNF_TYPE_HTTP) {
- if (fp->is_ready == 0)
- khttp_connect_file(fp);
- }
- if (fp->type == KNF_TYPE_LOCAL) { // on Windows, the following block is necessary; not on UNIX
- off_t rest = len, curr;
- while (rest) {
- curr = read(fp->fd, buf + l, rest);
- if (curr == 0) break;
- l += curr; rest -= curr;
- }
- } else l = my_netread(fp->fd, buf, len);
- fp->offset += l;
- return l;
-}
-
-off_t knet_seek(knetFile *fp, int64_t off, int whence)
-{
- if (whence == SEEK_SET && off == fp->offset) return 0;
- if (fp->type == KNF_TYPE_LOCAL) {
- /* Be aware that lseek() returns the offset after seeking,
- * while fseek() returns zero on success. */
- off_t offset = lseek(fp->fd, off, whence);
- if (offset == -1) {
- // Be silent, it is OK for knet_seek to fail when the file is streamed
- // fprintf(stderr,"[knet_seek] %s\n", strerror(errno));
- return -1;
- }
- fp->offset = offset;
- return 0;
- }
- else if (fp->type == KNF_TYPE_FTP)
- {
- if (whence==SEEK_CUR)
- fp->offset += off;
- else if (whence==SEEK_SET)
- fp->offset = off;
- else if ( whence==SEEK_END)
- fp->offset = fp->file_size+off;
- fp->is_ready = 0;
- return 0;
- }
- else if (fp->type == KNF_TYPE_HTTP)
- {
- if (whence == SEEK_END) { // FIXME: can we allow SEEK_END in future?
- fprintf(stderr, "[knet_seek] SEEK_END is not supported for HTTP. Offset is unchanged.\n");
- errno = ESPIPE;
- return -1;
- }
- if (whence==SEEK_CUR)
- fp->offset += off;
- else if (whence==SEEK_SET)
- fp->offset = off;
- fp->is_ready = 0;
- return 0;
- }
- errno = EINVAL;
- fprintf(stderr,"[knet_seek] %s\n", strerror(errno));
- return -1;
-}
-
-int knet_close(knetFile *fp)
-{
- if (fp == 0) return 0;
- if (fp->ctrl_fd != -1) netclose(fp->ctrl_fd); // FTP specific
- if (fp->fd != -1) {
- /* On Linux/Mac, netclose() is an alias of close(), but on
- * Windows, it is an alias of closesocket(). */
- if (fp->type == KNF_TYPE_LOCAL) close(fp->fd);
- else netclose(fp->fd);
- }
- free(fp->host); free(fp->port);
- free(fp->response); free(fp->retr); // FTP specific
- free(fp->path); free(fp->http_host); // HTTP specific
- free(fp);
- return 0;
-}
-
-#ifdef KNETFILE_MAIN
-int main(void)
-{
- char *buf;
- knetFile *fp;
- int type = 4, l;
-#ifdef _WIN32
- knet_win32_init();
-#endif
- buf = calloc(0x100000, 1);
- if (type == 0) {
- fp = knet_open("knetfile.c", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 1) { // NCBI FTP, large file
- fp = knet_open("ftp://ftp.ncbi.nih.gov/1000genomes/ftp/data/NA12878/alignment/NA12878.chrom6.SLX.SRP000032.2009_06.bam", "r");
- knet_seek(fp, 2500000000ll, SEEK_SET);
- l = knet_read(fp, buf, 255);
- } else if (type == 2) {
- fp = knet_open("ftp://ftp.sanger.ac.uk/pub4/treefam/tmp/index.shtml", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 3) {
- fp = knet_open("http://www.sanger.ac.uk/Users/lh3/index.shtml", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 4) {
- fp = knet_open("http://www.sanger.ac.uk/Users/lh3/ex1.bam", "r");
- knet_read(fp, buf, 10000);
- knet_seek(fp, 20000, SEEK_SET);
- knet_seek(fp, 10000, SEEK_SET);
- l = knet_read(fp, buf+10000, 10000000) + 10000;
- }
- if (type != 4 && type != 1) {
- knet_read(fp, buf, 255);
- buf[255] = 0;
- printf("%s\n", buf);
- } else write(fileno(stdout), buf, l);
- knet_close(fp);
- free(buf);
- return 0;
-}
-#endif
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008 by Genome Research Ltd (GRL).
+ 2010 by Attractive Chaos <attractor@live.co.uk>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+/* Probably I will not do socket programming in the next few years and
+ therefore I decide to heavily annotate this file, for Linux and
+ Windows as well. -ac */
+
+#include <time.h>
+#include <stdio.h>
+#include <ctype.h>
+#include <stdlib.h>
+#include <string.h>
+#include <errno.h>
+#include <unistd.h>
+#include <sys/types.h>
+
+#ifndef _WIN32
+#include <netdb.h>
+#include <arpa/inet.h>
+#include <sys/socket.h>
+#endif
+
+#include "knetfile.h"
+
+/* In winsock.h, the type of a socket is SOCKET, which is: "typedef
+ * u_int SOCKET". An invalid SOCKET is: "(SOCKET)(~0)", or signed
+ * integer -1. In knetfile.c, I use "int" for socket type
+ * throughout. This should be improved to avoid confusion.
+ *
+ * In Linux/Mac, recv() and read() do almost the same thing. You can see
+ * in the header file that netread() is simply an alias of read(). In
+ * Windows, however, they are different and using recv() is mandatory.
+ */
+
+/* This function tests if the file handler is ready for reading (or
+ * writing if is_read==0). */
+static int socket_wait(int fd, int is_read)
+{
+ fd_set fds, *fdr = 0, *fdw = 0;
+ struct timeval tv;
+ int ret;
+ tv.tv_sec = 5; tv.tv_usec = 0; // 5 seconds time out
+ FD_ZERO(&fds);
+ FD_SET(fd, &fds);
+ if (is_read) fdr = &fds;
+ else fdw = &fds;
+ ret = select(fd+1, fdr, fdw, 0, &tv);
+#ifndef _WIN32
+ if (ret == -1) perror("select");
+#else
+ if (ret == 0)
+ fprintf(pysamerr, "select time-out\n");
+ else if (ret == SOCKET_ERROR)
+ fprintf(pysamerr, "select: %d\n", WSAGetLastError());
+#endif
+ return ret;
+}
+
+#ifndef _WIN32
+/* This function does not work with Windows due to the lack of
+ * getaddrinfo() in winsock. It is addapted from an example in "Beej's
+ * Guide to Network Programming" (http://beej.us/guide/bgnet/). */
+static int socket_connect(const char *host, const char *port)
+{
+#define __err_connect(func) do { perror(func); freeaddrinfo(res); return -1; } while (0)
+
+ int on = 1, fd;
+ struct linger lng = { 0, 0 };
+ struct addrinfo hints, *res = 0;
+ memset(&hints, 0, sizeof(struct addrinfo));
+ hints.ai_family = AF_UNSPEC;
+ hints.ai_socktype = SOCK_STREAM;
+ /* In Unix/Mac, getaddrinfo() is the most convenient way to get
+ * server information. */
+ if (getaddrinfo(host, port, &hints, &res) != 0) __err_connect("getaddrinfo");
+ if ((fd = socket(res->ai_family, res->ai_socktype, res->ai_protocol)) == -1) __err_connect("socket");
+ /* The following two setsockopt() are used by ftplib
+ * (http://nbpfaus.net/~pfau/ftplib/). I am not sure if they
+ * necessary. */
+ if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &on, sizeof(on)) == -1) __err_connect("setsockopt");
+ if (setsockopt(fd, SOL_SOCKET, SO_LINGER, &lng, sizeof(lng)) == -1) __err_connect("setsockopt");
+ if (connect(fd, res->ai_addr, res->ai_addrlen) != 0) __err_connect("connect");
+ freeaddrinfo(res);
+ return fd;
+}
+#else
+/* MinGW's printf has problem with "%lld" */
+char *int64tostr(char *buf, int64_t x)
+{
+ int cnt;
+ int i = 0;
+ do {
+ buf[i++] = '0' + x % 10;
+ x /= 10;
+ } while (x);
+ buf[i] = 0;
+ for (cnt = i, i = 0; i < cnt/2; ++i) {
+ int c = buf[i]; buf[i] = buf[cnt-i-1]; buf[cnt-i-1] = c;
+ }
+ return buf;
+}
+
+int64_t strtoint64(const char *buf)
+{
+ int64_t x;
+ for (x = 0; *buf != '\0'; ++buf)
+ x = x * 10 + ((int64_t) *buf - 48);
+ return x;
+}
+/* In windows, the first thing is to establish the TCP connection. */
+int knet_win32_init()
+{
+ WSADATA wsaData;
+ return WSAStartup(MAKEWORD(2, 2), &wsaData);
+}
+void knet_win32_destroy()
+{
+ WSACleanup();
+}
+/* A slightly modfied version of the following function also works on
+ * Mac (and presummably Linux). However, this function is not stable on
+ * my Mac. It sometimes works fine but sometimes does not. Therefore for
+ * non-Windows OS, I do not use this one. */
+static SOCKET socket_connect(const char *host, const char *port)
+{
+#define __err_connect(func) \
+ do { \
+ fprintf(pysamerr, "%s: %d\n", func, WSAGetLastError()); \
+ return -1; \
+ } while (0)
+
+ int on = 1;
+ SOCKET fd;
+ struct linger lng = { 0, 0 };
+ struct sockaddr_in server;
+ struct hostent *hp = 0;
+ // open socket
+ if ((fd = socket(AF_INET, SOCK_STREAM, IPPROTO_TCP)) == INVALID_SOCKET) __err_connect("socket");
+ if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, (char*)&on, sizeof(on)) == -1) __err_connect("setsockopt");
+ if (setsockopt(fd, SOL_SOCKET, SO_LINGER, (char*)&lng, sizeof(lng)) == -1) __err_connect("setsockopt");
+ // get host info
+ if (isalpha(host[0])) hp = gethostbyname(host);
+ else {
+ struct in_addr addr;
+ addr.s_addr = inet_addr(host);
+ hp = gethostbyaddr((char*)&addr, 4, AF_INET);
+ }
+ if (hp == 0) __err_connect("gethost");
+ // connect
+ server.sin_addr.s_addr = *((unsigned long*)hp->h_addr);
+ server.sin_family= AF_INET;
+ server.sin_port = htons(atoi(port));
+ if (connect(fd, (struct sockaddr*)&server, sizeof(server)) != 0) __err_connect("connect");
+ // freehostent(hp); // strangely in MSDN, hp is NOT freed (memory leak?!)
+ return fd;
+}
+#endif
+
+static off_t my_netread(int fd, void *buf, off_t len)
+{
+ off_t rest = len, curr, l = 0;
+ /* recv() and read() may not read the required length of data with
+ * one call. They have to be called repeatedly. */
+ while (rest) {
+ if (socket_wait(fd, 1) <= 0) break; // socket is not ready for reading
+ curr = netread(fd, buf + l, rest);
+ /* According to the glibc manual, section 13.2, a zero returned
+ * value indicates end-of-file (EOF), which should mean that
+ * read() will not return zero if EOF has not been met but data
+ * are not immediately available. */
+ if (curr == 0) break;
+ l += curr; rest -= curr;
+ }
+ return l;
+}
+
+/*************************
+ * FTP specific routines *
+ *************************/
+
+static int kftp_get_response(knetFile *ftp)
+{
+#ifndef _WIN32
+ unsigned char c;
+#else
+ char c;
+#endif
+ int n = 0;
+ char *p;
+ if (socket_wait(ftp->ctrl_fd, 1) <= 0) return 0;
+ while (netread(ftp->ctrl_fd, &c, 1)) { // FIXME: this is *VERY BAD* for unbuffered I/O
+ //fputc(c, pysamerr);
+ if (n >= ftp->max_response) {
+ ftp->max_response = ftp->max_response? ftp->max_response<<1 : 256;
+ ftp->response = realloc(ftp->response, ftp->max_response);
+ }
+ ftp->response[n++] = c;
+ if (c == '\n') {
+ if (n >= 4 && isdigit(ftp->response[0]) && isdigit(ftp->response[1]) && isdigit(ftp->response[2])
+ && ftp->response[3] != '-') break;
+ n = 0;
+ continue;
+ }
+ }
+ if (n < 2) return -1;
+ ftp->response[n-2] = 0;
+ return strtol(ftp->response, &p, 0);
+}
+
+static int kftp_send_cmd(knetFile *ftp, const char *cmd, int is_get)
+{
+ if (socket_wait(ftp->ctrl_fd, 0) <= 0) return -1; // socket is not ready for writing
+ netwrite(ftp->ctrl_fd, cmd, strlen(cmd));
+ return is_get? kftp_get_response(ftp) : 0;
+}
+
+static int kftp_pasv_prep(knetFile *ftp)
+{
+ char *p;
+ int v[6];
+ kftp_send_cmd(ftp, "PASV\r\n", 1);
+ for (p = ftp->response; *p && *p != '('; ++p);
+ if (*p != '(') return -1;
+ ++p;
+ sscanf(p, "%d,%d,%d,%d,%d,%d", &v[0], &v[1], &v[2], &v[3], &v[4], &v[5]);
+ memcpy(ftp->pasv_ip, v, 4 * sizeof(int));
+ ftp->pasv_port = (v[4]<<8&0xff00) + v[5];
+ return 0;
+}
+
+
+static int kftp_pasv_connect(knetFile *ftp)
+{
+ char host[80], port[10];
+ if (ftp->pasv_port == 0) {
+ fprintf(pysamerr, "[kftp_pasv_connect] kftp_pasv_prep() is not called before hand.\n");
+ return -1;
+ }
+ sprintf(host, "%d.%d.%d.%d", ftp->pasv_ip[0], ftp->pasv_ip[1], ftp->pasv_ip[2], ftp->pasv_ip[3]);
+ sprintf(port, "%d", ftp->pasv_port);
+ ftp->fd = socket_connect(host, port);
+ if (ftp->fd == -1) return -1;
+ return 0;
+}
+
+int kftp_connect(knetFile *ftp)
+{
+ ftp->ctrl_fd = socket_connect(ftp->host, ftp->port);
+ if (ftp->ctrl_fd == -1) return -1;
+ kftp_get_response(ftp);
+ kftp_send_cmd(ftp, "USER anonymous\r\n", 1);
+ kftp_send_cmd(ftp, "PASS kftp@\r\n", 1);
+ kftp_send_cmd(ftp, "TYPE I\r\n", 1);
+ return 0;
+}
+
+int kftp_reconnect(knetFile *ftp)
+{
+ if (ftp->ctrl_fd != -1) {
+ netclose(ftp->ctrl_fd);
+ ftp->ctrl_fd = -1;
+ }
+ netclose(ftp->fd);
+ ftp->fd = -1;
+ return kftp_connect(ftp);
+}
+
+// initialize ->type, ->host, ->retr and ->size
+knetFile *kftp_parse_url(const char *fn, const char *mode)
+{
+ knetFile *fp;
+ char *p;
+ int l;
+ if (strstr(fn, "ftp://") != fn) return 0;
+ for (p = (char*)fn + 6; *p && *p != '/'; ++p);
+ if (*p != '/') return 0;
+ l = p - fn - 6;
+ fp = calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_FTP;
+ fp->fd = -1;
+ /* the Linux/Mac version of socket_connect() also recognizes a port
+ * like "ftp", but the Windows version does not. */
+ fp->port = strdup("21");
+ fp->host = calloc(l + 1, 1);
+ if (strchr(mode, 'c')) fp->no_reconnect = 1;
+ strncpy(fp->host, fn + 6, l);
+ fp->retr = calloc(strlen(p) + 8, 1);
+ sprintf(fp->retr, "RETR %s\r\n", p);
+ fp->size_cmd = calloc(strlen(p) + 8, 1);
+ sprintf(fp->size_cmd, "SIZE %s\r\n", p);
+ fp->seek_offset = 0;
+ return fp;
+}
+// place ->fd at offset off
+int kftp_connect_file(knetFile *fp)
+{
+ int ret;
+ long long file_size;
+ if (fp->fd != -1) {
+ netclose(fp->fd);
+ if (fp->no_reconnect) kftp_get_response(fp);
+ }
+ kftp_pasv_prep(fp);
+ kftp_send_cmd(fp, fp->size_cmd, 1);
+#ifndef _WIN32
+ if ( sscanf(fp->response,"%*d %lld", &file_size) != 1 )
+ {
+ fprintf(pysamerr,"[kftp_connect_file] %s\n", fp->response);
+ return -1;
+ }
+#else
+ const char *p = fp->response;
+ while (*p != ' ') ++p;
+ while (*p < '0' || *p > '9') ++p;
+ file_size = strtoint64(p);
+#endif
+ fp->file_size = file_size;
+ if (fp->offset>=0) {
+ char tmp[32];
+#ifndef _WIN32
+ sprintf(tmp, "REST %lld\r\n", (long long)fp->offset);
+#else
+ strcpy(tmp, "REST ");
+ int64tostr(tmp + 5, fp->offset);
+ strcat(tmp, "\r\n");
+#endif
+ kftp_send_cmd(fp, tmp, 1);
+ }
+ kftp_send_cmd(fp, fp->retr, 0);
+ kftp_pasv_connect(fp);
+ ret = kftp_get_response(fp);
+ if (ret != 150) {
+ fprintf(pysamerr, "[kftp_connect_file] %s\n", fp->response);
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ fp->is_ready = 1;
+ return 0;
+}
+
+
+/**************************
+ * HTTP specific routines *
+ **************************/
+
+knetFile *khttp_parse_url(const char *fn, const char *mode)
+{
+ knetFile *fp;
+ char *p, *proxy, *q;
+ int l;
+ if (strstr(fn, "http://") != fn) return 0;
+ // set ->http_host
+ for (p = (char*)fn + 7; *p && *p != '/'; ++p);
+ l = p - fn - 7;
+ fp = calloc(1, sizeof(knetFile));
+ fp->http_host = calloc(l + 1, 1);
+ strncpy(fp->http_host, fn + 7, l);
+ fp->http_host[l] = 0;
+ for (q = fp->http_host; *q && *q != ':'; ++q);
+ if (*q == ':') *q++ = 0;
+ // get http_proxy
+ proxy = getenv("http_proxy");
+ // set ->host, ->port and ->path
+ if (proxy == 0) {
+ fp->host = strdup(fp->http_host); // when there is no proxy, server name is identical to http_host name.
+ fp->port = strdup(*q? q : "80");
+ fp->path = strdup(*p? p : "/");
+ } else {
+ fp->host = (strstr(proxy, "http://") == proxy)? strdup(proxy + 7) : strdup(proxy);
+ for (q = fp->host; *q && *q != ':'; ++q);
+ if (*q == ':') *q++ = 0;
+ fp->port = strdup(*q? q : "80");
+ fp->path = strdup(fn);
+ }
+ fp->type = KNF_TYPE_HTTP;
+ fp->ctrl_fd = fp->fd = -1;
+ fp->seek_offset = 0;
+ return fp;
+}
+
+int khttp_connect_file(knetFile *fp)
+{
+ int ret, l = 0;
+ char *buf, *p;
+ if (fp->fd != -1) netclose(fp->fd);
+ fp->fd = socket_connect(fp->host, fp->port);
+ buf = calloc(0x10000, 1); // FIXME: I am lazy... But in principle, 64KB should be large enough.
+ l += sprintf(buf + l, "GET %s HTTP/1.0\r\nHost: %s\r\n", fp->path, fp->http_host);
+ l += sprintf(buf + l, "Range: bytes=%lld-\r\n", (long long)fp->offset);
+ l += sprintf(buf + l, "\r\n");
+ netwrite(fp->fd, buf, l);
+ l = 0;
+ while (netread(fp->fd, buf + l, 1)) { // read HTTP header; FIXME: bad efficiency
+ if (buf[l] == '\n' && l >= 3)
+ if (strncmp(buf + l - 3, "\r\n\r\n", 4) == 0) break;
+ ++l;
+ }
+ buf[l] = 0;
+ if (l < 14) { // prematured header
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ ret = strtol(buf + 8, &p, 0); // HTTP return code
+ if (ret == 200 && fp->offset>0) { // 200 (complete result); then skip beginning of the file
+ off_t rest = fp->offset;
+ while (rest) {
+ off_t l = rest < 0x10000? rest : 0x10000;
+ rest -= my_netread(fp->fd, buf, l);
+ }
+ } else if (ret != 206 && ret != 200) {
+ free(buf);
+ fprintf(pysamerr, "[khttp_connect_file] fail to open file (HTTP code: %d).\n", ret);
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ free(buf);
+ fp->is_ready = 1;
+ return 0;
+}
+
+/********************
+ * Generic routines *
+ ********************/
+
+knetFile *knet_open(const char *fn, const char *mode)
+{
+ knetFile *fp = 0;
+ if (mode[0] != 'r') {
+ fprintf(pysamerr, "[kftp_open] only mode \"r\" is supported.\n");
+ return 0;
+ }
+ if (strstr(fn, "ftp://") == fn) {
+ fp = kftp_parse_url(fn, mode);
+ if (fp == 0) return 0;
+ if (kftp_connect(fp) == -1) {
+ knet_close(fp);
+ return 0;
+ }
+ kftp_connect_file(fp);
+ } else if (strstr(fn, "http://") == fn) {
+ fp = khttp_parse_url(fn, mode);
+ if (fp == 0) return 0;
+ khttp_connect_file(fp);
+ } else { // local file
+#ifdef _WIN32
+ /* In windows, O_BINARY is necessary. In Linux/Mac, O_BINARY may
+ * be undefined on some systems, although it is defined on my
+ * Mac and the Linux I have tested on. */
+ int fd = open(fn, O_RDONLY | O_BINARY);
+#else
+ int fd = open(fn, O_RDONLY);
+#endif
+ if (fd == -1) {
+ perror("open");
+ return 0;
+ }
+ fp = (knetFile*)calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_LOCAL;
+ fp->fd = fd;
+ fp->ctrl_fd = -1;
+ }
+ if (fp && fp->fd == -1) {
+ knet_close(fp);
+ return 0;
+ }
+ return fp;
+}
+
+knetFile *knet_dopen(int fd, const char *mode)
+{
+ knetFile *fp = (knetFile*)calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_LOCAL;
+ fp->fd = fd;
+ return fp;
+}
+
+off_t knet_read(knetFile *fp, void *buf, off_t len)
+{
+ off_t l = 0;
+ if (fp->fd == -1) return 0;
+ if (fp->type == KNF_TYPE_FTP) {
+ if (fp->is_ready == 0) {
+ if (!fp->no_reconnect) kftp_reconnect(fp);
+ kftp_connect_file(fp);
+ }
+ } else if (fp->type == KNF_TYPE_HTTP) {
+ if (fp->is_ready == 0)
+ khttp_connect_file(fp);
+ }
+ if (fp->type == KNF_TYPE_LOCAL) { // on Windows, the following block is necessary; not on UNIX
+ off_t rest = len, curr;
+ while (rest) {
+ do {
+ curr = read(fp->fd, buf + l, rest);
+ } while (curr < 0 && EINTR == errno);
+ if (curr < 0) return -1;
+ if (curr == 0) break;
+ l += curr; rest -= curr;
+ }
+ } else l = my_netread(fp->fd, buf, len);
+ fp->offset += l;
+ return l;
+}
+
+off_t knet_seek(knetFile *fp, int64_t off, int whence)
+{
+ if (whence == SEEK_SET && off == fp->offset) return 0;
+ if (fp->type == KNF_TYPE_LOCAL) {
+ /* Be aware that lseek() returns the offset after seeking,
+ * while fseek() returns zero on success. */
+ off_t offset = lseek(fp->fd, off, whence);
+ if (offset == -1) {
+ // Be silent, it is OK for knet_seek to fail when the file is streamed
+ // fprintf(pysamerr,"[knet_seek] %s\n", strerror(errno));
+ return -1;
+ }
+ fp->offset = offset;
+ return 0;
+ }
+ else if (fp->type == KNF_TYPE_FTP)
+ {
+ if (whence==SEEK_CUR)
+ fp->offset += off;
+ else if (whence==SEEK_SET)
+ fp->offset = off;
+ else if ( whence==SEEK_END)
+ fp->offset = fp->file_size+off;
+ fp->is_ready = 0;
+ return 0;
+ }
+ else if (fp->type == KNF_TYPE_HTTP)
+ {
+ if (whence == SEEK_END) { // FIXME: can we allow SEEK_END in future?
+ fprintf(pysamerr, "[knet_seek] SEEK_END is not supported for HTTP. Offset is unchanged.\n");
+ errno = ESPIPE;
+ return -1;
+ }
+ if (whence==SEEK_CUR)
+ fp->offset += off;
+ else if (whence==SEEK_SET)
+ fp->offset = off;
+ fp->is_ready = 0;
+ return 0;
+ }
+ errno = EINVAL;
+ fprintf(pysamerr,"[knet_seek] %s\n", strerror(errno));
+ return -1;
+}
+
+int knet_close(knetFile *fp)
+{
+ if (fp == 0) return 0;
+ if (fp->ctrl_fd != -1) netclose(fp->ctrl_fd); // FTP specific
+ if (fp->fd != -1) {
+ /* On Linux/Mac, netclose() is an alias of close(), but on
+ * Windows, it is an alias of closesocket(). */
+ if (fp->type == KNF_TYPE_LOCAL) close(fp->fd);
+ else netclose(fp->fd);
+ }
+ free(fp->host); free(fp->port);
+ free(fp->response); free(fp->retr); // FTP specific
+ free(fp->path); free(fp->http_host); // HTTP specific
+ free(fp);
+ return 0;
+}
+
+#ifdef KNETFILE_MAIN
+int main(void)
+{
+ char *buf;
+ knetFile *fp;
+ int type = 4, l;
+#ifdef _WIN32
+ knet_win32_init();
+#endif
+ buf = calloc(0x100000, 1);
+ if (type == 0) {
+ fp = knet_open("knetfile.c", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 1) { // NCBI FTP, large file
+ fp = knet_open("ftp://ftp.ncbi.nih.gov/1000genomes/ftp/data/NA12878/alignment/NA12878.chrom6.SLX.SRP000032.2009_06.bam", "r");
+ knet_seek(fp, 2500000000ll, SEEK_SET);
+ l = knet_read(fp, buf, 255);
+ } else if (type == 2) {
+ fp = knet_open("ftp://ftp.sanger.ac.uk/pub4/treefam/tmp/index.shtml", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 3) {
+ fp = knet_open("http://www.sanger.ac.uk/Users/lh3/index.shtml", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 4) {
+ fp = knet_open("http://www.sanger.ac.uk/Users/lh3/ex1.bam", "r");
+ knet_read(fp, buf, 10000);
+ knet_seek(fp, 20000, SEEK_SET);
+ knet_seek(fp, 10000, SEEK_SET);
+ l = knet_read(fp, buf+10000, 10000000) + 10000;
+ }
+ if (type != 4 && type != 1) {
+ knet_read(fp, buf, 255);
+ buf[255] = 0;
+ printf("%s\n", buf);
+ } else write(fileno(stdout), buf, l);
+ knet_close(fp);
+ free(buf);
+ return 0;
+}
+#endif
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2003-2006, 2008-2010, by Heng Li <lh3lh3@live.co.uk>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+#include <stdlib.h>
+#include <stdio.h>
+#include <string.h>
+#include <stdint.h>
+#include <math.h>
+#include "kprobaln.h"
+
+/*****************************************
+ * Probabilistic banded glocal alignment *
+ *****************************************/
+
+#define EI .25
+#define EM .33333333333
+
+static float g_qual2prob[256];
+
+#define set_u(u, b, i, k) { int x=(i)-(b); x=x>0?x:0; (u)=((k)-x+1)*3; }
+
+kpa_par_t kpa_par_def = { 0.001, 0.1, 10 };
+kpa_par_t kpa_par_alt = { 0.0001, 0.01, 10 };
+
+/*
+ The topology of the profile HMM:
+
+ /\ /\ /\ /\
+ I[1] I[k-1] I[k] I[L]
+ ^ \ \ ^ \ ^ \ \ ^
+ | \ \ | \ | \ \ |
+ M[0] M[1] -> ... -> M[k-1] -> M[k] -> ... -> M[L] M[L+1]
+ \ \/ \/ \/ /
+ \ /\ /\ /\ /
+ -> D[k-1] -> D[k] ->
+
+ M[0] points to every {M,I}[k] and every {M,I}[k] points M[L+1].
+
+ On input, _ref is the reference sequence and _query is the query
+ sequence. Both are sequences of 0/1/2/3/4 where 4 stands for an
+ ambiguous residue. iqual is the base quality. c sets the gap open
+ probability, gap extension probability and band width.
+
+ On output, state and q are arrays of length l_query. The higher 30
+ bits give the reference position the query base is matched to and the
+ lower two bits can be 0 (an alignment match) or 1 (an
+ insertion). q[i] gives the phred scaled posterior probability of
+ state[i] being wrong.
+ */
+int kpa_glocal(const uint8_t *_ref, int l_ref, const uint8_t *_query, int l_query, const uint8_t *iqual,
+ const kpa_par_t *c, int *state, uint8_t *q)
+{
+ double **f, **b = 0, *s, m[9], sI, sM, bI, bM, pb;
+ float *qual, *_qual;
+ const uint8_t *ref, *query;
+ int bw, bw2, i, k, is_diff = 0, is_backward = 1, Pr;
+
+ /*** initialization ***/
+ is_backward = state && q? 1 : 0;
+ ref = _ref - 1; query = _query - 1; // change to 1-based coordinate
+ bw = l_ref > l_query? l_ref : l_query;
+ if (bw > c->bw) bw = c->bw;
+ if (bw < abs(l_ref - l_query)) bw = abs(l_ref - l_query);
+ bw2 = bw * 2 + 1;
+ // allocate the forward and backward matrices f[][] and b[][] and the scaling array s[]
+ f = calloc(l_query+1, sizeof(void*));
+ if (is_backward) b = calloc(l_query+1, sizeof(void*));
+ for (i = 0; i <= l_query; ++i) {
+ f[i] = calloc(bw2 * 3 + 6, sizeof(double)); // FIXME: this is over-allocated for very short seqs
+ if (is_backward) b[i] = calloc(bw2 * 3 + 6, sizeof(double));
+ }
+ s = calloc(l_query+2, sizeof(double)); // s[] is the scaling factor to avoid underflow
+ // initialize qual
+ _qual = calloc(l_query, sizeof(float));
+ if (g_qual2prob[0] == 0)
+ for (i = 0; i < 256; ++i)
+ g_qual2prob[i] = pow(10, -i/10.);
+ for (i = 0; i < l_query; ++i) _qual[i] = g_qual2prob[iqual? iqual[i] : 30];
+ qual = _qual - 1;
+ // initialize transition probability
+ sM = sI = 1. / (2 * l_query + 2); // the value here seems not to affect results; FIXME: need proof
+ m[0*3+0] = (1 - c->d - c->d) * (1 - sM); m[0*3+1] = m[0*3+2] = c->d * (1 - sM);
+ m[1*3+0] = (1 - c->e) * (1 - sI); m[1*3+1] = c->e * (1 - sI); m[1*3+2] = 0.;
+ m[2*3+0] = 1 - c->e; m[2*3+1] = 0.; m[2*3+2] = c->e;
+ bM = (1 - c->d) / l_ref; bI = c->d / l_ref; // (bM+bI)*l_ref==1
+ /*** forward ***/
+ // f[0]
+ set_u(k, bw, 0, 0);
+ f[0][k] = s[0] = 1.;
+ { // f[1]
+ double *fi = f[1], sum;
+ int beg = 1, end = l_ref < bw + 1? l_ref : bw + 1, _beg, _end;
+ for (k = beg, sum = 0.; k <= end; ++k) {
+ int u;
+ double e = (ref[k] > 3 || query[1] > 3)? 1. : ref[k] == query[1]? 1. - qual[1] : qual[1] * EM;
+ set_u(u, bw, 1, k);
+ fi[u+0] = e * bM; fi[u+1] = EI * bI;
+ sum += fi[u] + fi[u+1];
+ }
+ // rescale
+ s[1] = sum;
+ set_u(_beg, bw, 1, beg); set_u(_end, bw, 1, end); _end += 2;
+ for (k = _beg; k <= _end; ++k) fi[k] /= sum;
+ }
+ // f[2..l_query]
+ for (i = 2; i <= l_query; ++i) {
+ double *fi = f[i], *fi1 = f[i-1], sum, qli = qual[i];
+ int beg = 1, end = l_ref, x, _beg, _end;
+ uint8_t qyi = query[i];
+ x = i - bw; beg = beg > x? beg : x; // band start
+ x = i + bw; end = end < x? end : x; // band end
+ for (k = beg, sum = 0.; k <= end; ++k) {
+ int u, v11, v01, v10;
+ double e;
+ e = (ref[k] > 3 || qyi > 3)? 1. : ref[k] == qyi? 1. - qli : qli * EM;
+ set_u(u, bw, i, k); set_u(v11, bw, i-1, k-1); set_u(v10, bw, i-1, k); set_u(v01, bw, i, k-1);
+ fi[u+0] = e * (m[0] * fi1[v11+0] + m[3] * fi1[v11+1] + m[6] * fi1[v11+2]);
+ fi[u+1] = EI * (m[1] * fi1[v10+0] + m[4] * fi1[v10+1]);
+ fi[u+2] = m[2] * fi[v01+0] + m[8] * fi[v01+2];
+ sum += fi[u] + fi[u+1] + fi[u+2];
+// fprintf(pysamerr, "F (%d,%d;%d): %lg,%lg,%lg\n", i, k, u, fi[u], fi[u+1], fi[u+2]); // DEBUG
+ }
+ // rescale
+ s[i] = sum;
+ set_u(_beg, bw, i, beg); set_u(_end, bw, i, end); _end += 2;
+ for (k = _beg, sum = 1./sum; k <= _end; ++k) fi[k] *= sum;
+ }
+ { // f[l_query+1]
+ double sum;
+ for (k = 1, sum = 0.; k <= l_ref; ++k) {
+ int u;
+ set_u(u, bw, l_query, k);
+ if (u < 3 || u >= bw2*3+3) continue;
+ sum += f[l_query][u+0] * sM + f[l_query][u+1] * sI;
+ }
+ s[l_query+1] = sum; // the last scaling factor
+ }
+ { // compute likelihood
+ double p = 1., Pr1 = 0.;
+ for (i = 0; i <= l_query + 1; ++i) {
+ p *= s[i];
+ if (p < 1e-100) Pr += -4.343 * log(p), p = 1.;
+ }
+ Pr1 += -4.343 * log(p * l_ref * l_query);
+ Pr = (int)(Pr1 + .499);
+ if (!is_backward) { // skip backward and MAP
+ for (i = 0; i <= l_query; ++i) free(f[i]);
+ free(f); free(s); free(_qual);
+ return Pr;
+ }
+ }
+ /*** backward ***/
+ // b[l_query] (b[l_query+1][0]=1 and thus \tilde{b}[][]=1/s[l_query+1]; this is where s[l_query+1] comes from)
+ for (k = 1; k <= l_ref; ++k) {
+ int u;
+ double *bi = b[l_query];
+ set_u(u, bw, l_query, k);
+ if (u < 3 || u >= bw2*3+3) continue;
+ bi[u+0] = sM / s[l_query] / s[l_query+1]; bi[u+1] = sI / s[l_query] / s[l_query+1];
+ }
+ // b[l_query-1..1]
+ for (i = l_query - 1; i >= 1; --i) {
+ int beg = 1, end = l_ref, x, _beg, _end;
+ double *bi = b[i], *bi1 = b[i+1], y = (i > 1), qli1 = qual[i+1];
+ uint8_t qyi1 = query[i+1];
+ x = i - bw; beg = beg > x? beg : x;
+ x = i + bw; end = end < x? end : x;
+ for (k = end; k >= beg; --k) {
+ int u, v11, v01, v10;
+ double e;
+ set_u(u, bw, i, k); set_u(v11, bw, i+1, k+1); set_u(v10, bw, i+1, k); set_u(v01, bw, i, k+1);
+ e = (k >= l_ref? 0 : (ref[k+1] > 3 || qyi1 > 3)? 1. : ref[k+1] == qyi1? 1. - qli1 : qli1 * EM) * bi1[v11];
+ bi[u+0] = e * m[0] + EI * m[1] * bi1[v10+1] + m[2] * bi[v01+2]; // bi1[v11] has been foled into e.
+ bi[u+1] = e * m[3] + EI * m[4] * bi1[v10+1];
+ bi[u+2] = (e * m[6] + m[8] * bi[v01+2]) * y;
+// fprintf(pysamerr, "B (%d,%d;%d): %lg,%lg,%lg\n", i, k, u, bi[u], bi[u+1], bi[u+2]); // DEBUG
+ }
+ // rescale
+ set_u(_beg, bw, i, beg); set_u(_end, bw, i, end); _end += 2;
+ for (k = _beg, y = 1./s[i]; k <= _end; ++k) bi[k] *= y;
+ }
+ { // b[0]
+ int beg = 1, end = l_ref < bw + 1? l_ref : bw + 1;
+ double sum = 0.;
+ for (k = end; k >= beg; --k) {
+ int u;
+ double e = (ref[k] > 3 || query[1] > 3)? 1. : ref[k] == query[1]? 1. - qual[1] : qual[1] * EM;
+ set_u(u, bw, 1, k);
+ if (u < 3 || u >= bw2*3+3) continue;
+ sum += e * b[1][u+0] * bM + EI * b[1][u+1] * bI;
+ }
+ set_u(k, bw, 0, 0);
+ pb = b[0][k] = sum / s[0]; // if everything works as is expected, pb == 1.0
+ }
+ is_diff = fabs(pb - 1.) > 1e-7? 1 : 0;
+ /*** MAP ***/
+ for (i = 1; i <= l_query; ++i) {
+ double sum = 0., *fi = f[i], *bi = b[i], max = 0.;
+ int beg = 1, end = l_ref, x, max_k = -1;
+ x = i - bw; beg = beg > x? beg : x;
+ x = i + bw; end = end < x? end : x;
+ for (k = beg; k <= end; ++k) {
+ int u;
+ double z;
+ set_u(u, bw, i, k);
+ z = fi[u+0] * bi[u+0]; if (z > max) max = z, max_k = (k-1)<<2 | 0; sum += z;
+ z = fi[u+1] * bi[u+1]; if (z > max) max = z, max_k = (k-1)<<2 | 1; sum += z;
+ }
+ max /= sum; sum *= s[i]; // if everything works as is expected, sum == 1.0
+ if (state) state[i-1] = max_k;
+ if (q) k = (int)(-4.343 * log(1. - max) + .499), q[i-1] = k > 100? 99 : k;
+#ifdef _MAIN
+ fprintf(pysamerr, "(%.10lg,%.10lg) (%d,%d:%c,%c:%d) %lg\n", pb, sum, i-1, max_k>>2,
+ "ACGT"[query[i]], "ACGT"[ref[(max_k>>2)+1]], max_k&3, max); // DEBUG
+#endif
+ }
+ /*** free ***/
+ for (i = 0; i <= l_query; ++i) {
+ free(f[i]); free(b[i]);
+ }
+ free(f); free(b); free(s); free(_qual);
+ return Pr;
+}
+
+#ifdef _MAIN
+#include <unistd.h>
+int main(int argc, char *argv[])
+{
+ uint8_t conv[256], *iqual, *ref, *query;
+ int c, l_ref, l_query, i, q = 30, b = 10, P;
+ while ((c = getopt(argc, argv, "b:q:")) >= 0) {
+ switch (c) {
+ case 'b': b = atoi(optarg); break;
+ case 'q': q = atoi(optarg); break;
+ }
+ }
+ if (optind + 2 > argc) {
+ fprintf(pysamerr, "Usage: %s [-q %d] [-b %d] <ref> <query>\n", argv[0], q, b); // example: acttc attc
+ return 1;
+ }
+ memset(conv, 4, 256);
+ conv['a'] = conv['A'] = 0; conv['c'] = conv['C'] = 1;
+ conv['g'] = conv['G'] = 2; conv['t'] = conv['T'] = 3;
+ ref = (uint8_t*)argv[optind]; query = (uint8_t*)argv[optind+1];
+ l_ref = strlen((char*)ref); l_query = strlen((char*)query);
+ for (i = 0; i < l_ref; ++i) ref[i] = conv[ref[i]];
+ for (i = 0; i < l_query; ++i) query[i] = conv[query[i]];
+ iqual = malloc(l_query);
+ memset(iqual, q, l_query);
+ kpa_par_def.bw = b;
+ P = kpa_glocal(ref, l_ref, query, l_query, iqual, &kpa_par_alt, 0, 0);
+ fprintf(pysamerr, "%d\n", P);
+ free(iqual);
+ return 0;
+}
+#endif
--- /dev/null
+/* The MIT License
+
+ Copyright (c) 2003-2006, 2008, 2009 by Heng Li <lh3@live.co.uk>
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+#ifndef LH3_KPROBALN_H_
+#define LH3_KPROBALN_H_
+
+#include <stdint.h>
+
+typedef struct {
+ float d, e;
+ int bw;
+} kpa_par_t;
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ int kpa_glocal(const uint8_t *_ref, int l_ref, const uint8_t *_query, int l_query, const uint8_t *iqual,
+ const kpa_par_t *c, int *state, uint8_t *q);
+
+#ifdef __cplusplus
+}
+#endif
+
+extern kpa_par_t kpa_par_def, kpa_par_alt;
+
+#endif
if (hh <= k) low = ll; \
if (hh >= k) high = hh - 1; \
} \
+ } \
+ void ks_shuffle_##name(size_t n, type_t a[]) \
+ { \
+ int i, j; \
+ for (i = n; i > 1; --i) { \
+ type_t tmp; \
+ j = (int)(drand48() * i); \
+ tmp = a[j]; a[j] = a[i-1]; a[i-1] = tmp; \
+ } \
}
#define ks_mergesort(name, n, a, t) ks_mergesort_##name(n, a, t)
#define ks_heapmake(name, n, a) ks_heapmake_##name(n, a)
#define ks_heapadjust(name, i, n, a) ks_heapadjust_##name(i, n, a)
#define ks_ksmall(name, n, a, k) ks_ksmall_##name(n, a, k)
+#define ks_shuffle(name, n, a) ks_shuffle_##name(n, a)
#define ks_lt_generic(a, b) ((a) < (b))
#define ks_lt_str(a, b) (strcmp((a), (b)) < 0)
+++ /dev/null
-#include <stdarg.h>
-#include <stdio.h>
-#include <ctype.h>
-#include <string.h>
-#include <stdint.h>
-#include "kstring.h"
-
-int ksprintf(kstring_t *s, const char *fmt, ...)
-{
- va_list ap;
- int l;
- va_start(ap, fmt);
- l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap); // This line does not work with glibc 2.0. See `man snprintf'.
- va_end(ap);
- if (l + 1 > s->m - s->l) {
- s->m = s->l + l + 2;
- kroundup32(s->m);
- s->s = (char*)realloc(s->s, s->m);
- va_start(ap, fmt);
- l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap);
- }
- va_end(ap);
- s->l += l;
- return l;
-}
-
-// s MUST BE a null terminated string; l = strlen(s)
-int ksplit_core(char *s, int delimiter, int *_max, int **_offsets)
-{
- int i, n, max, last_char, last_start, *offsets, l;
- n = 0; max = *_max; offsets = *_offsets;
- l = strlen(s);
-
-#define __ksplit_aux do { \
- if (_offsets) { \
- s[i] = 0; \
- if (n == max) { \
- max = max? max<<1 : 2; \
- offsets = (int*)realloc(offsets, sizeof(int) * max); \
- } \
- offsets[n++] = last_start; \
- } else ++n; \
- } while (0)
-
- for (i = 0, last_char = last_start = 0; i <= l; ++i) {
- if (delimiter == 0) {
- if (isspace(s[i]) || s[i] == 0) {
- if (isgraph(last_char)) __ksplit_aux; // the end of a field
- } else {
- if (isspace(last_char) || last_char == 0) last_start = i;
- }
- } else {
- if (s[i] == delimiter || s[i] == 0) {
- if (last_char != 0 && last_char != delimiter) __ksplit_aux; // the end of a field
- } else {
- if (last_char == delimiter || last_char == 0) last_start = i;
- }
- }
- last_char = s[i];
- }
- *_max = max; *_offsets = offsets;
- return n;
-}
-
-/**********************
- * Boyer-Moore search *
- **********************/
-
-// reference: http://www-igm.univ-mlv.fr/~lecroq/string/node14.html
-int *ksBM_prep(const uint8_t *pat, int m)
-{
- int i, *suff, *prep, *bmGs, *bmBc;
- prep = calloc(m + 256, 1);
- bmGs = prep; bmBc = prep + m;
- { // preBmBc()
- for (i = 0; i < 256; ++i) bmBc[i] = m;
- for (i = 0; i < m - 1; ++i) bmBc[pat[i]] = m - i - 1;
- }
- suff = calloc(m, sizeof(int));
- { // suffixes()
- int f = 0, g;
- suff[m - 1] = m;
- g = m - 1;
- for (i = m - 2; i >= 0; --i) {
- if (i > g && suff[i + m - 1 - f] < i - g)
- suff[i] = suff[i + m - 1 - f];
- else {
- if (i < g) g = i;
- f = i;
- while (g >= 0 && pat[g] == pat[g + m - 1 - f]) --g;
- suff[i] = f - g;
- }
- }
- }
- { // preBmGs()
- int j = 0;
- for (i = 0; i < m; ++i) bmGs[i] = m;
- for (i = m - 1; i >= 0; --i)
- if (suff[i] == i + 1)
- for (; j < m - 1 - i; ++j)
- if (bmGs[j] == m)
- bmGs[j] = m - 1 - i;
- for (i = 0; i <= m - 2; ++i)
- bmGs[m - 1 - suff[i]] = m - 1 - i;
- }
- free(suff);
- return prep;
-}
-
-int *ksBM_search(const uint8_t *str, int n, const uint8_t *pat, int m, int *_prep, int *n_matches)
-{
- int i, j, *prep, *bmGs, *bmBc;
- int *matches = 0, mm = 0, nm = 0;
- prep = _prep? _prep : ksBM_prep(pat, m);
- bmGs = prep; bmBc = prep + m;
- j = 0;
- while (j <= n - m) {
- for (i = m - 1; i >= 0 && pat[i] == str[i+j]; --i);
- if (i < 0) {
- if (nm == mm) {
- mm = mm? mm<<1 : 1;
- matches = realloc(matches, mm * sizeof(int));
- }
- matches[nm++] = j;
- j += bmGs[0];
- } else {
- int max = bmBc[str[i+j]] - m + 1 + i;
- if (max < bmGs[i]) max = bmGs[i];
- j += max;
- }
- }
- *n_matches = nm;
- if (_prep == 0) free(prep);
- return matches;
-}
-
-#ifdef KSTRING_MAIN
-#include <stdio.h>
-int main()
-{
- kstring_t *s;
- int *fields, n, i;
- s = (kstring_t*)calloc(1, sizeof(kstring_t));
- // test ksprintf()
- ksprintf(s, " abcdefg: %d ", 100);
- printf("'%s'\n", s->s);
- // test ksplit()
- fields = ksplit(s, 0, &n);
- for (i = 0; i < n; ++i)
- printf("field[%d] = '%s'\n", i, s->s + fields[i]);
- free(s);
-
- {
- static char *str = "abcdefgcdg";
- static char *pat = "cd";
- int n, *matches;
- matches = ksBM_search(str, strlen(str), pat, strlen(pat), 0, &n);
- printf("%d: \n", n);
- for (i = 0; i < n; ++i)
- printf("- %d\n", matches[i]);
- free(matches);
- }
- return 0;
-}
-#endif
--- /dev/null
+#include "pysam.h"
+
+#include <stdarg.h>
+#include <stdio.h>
+#include <ctype.h>
+#include <string.h>
+#include <stdint.h>
+#include "kstring.h"
+
+int ksprintf(kstring_t *s, const char *fmt, ...)
+{
+ va_list ap;
+ int l;
+ va_start(ap, fmt);
+ l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap); // This line does not work with glibc 2.0. See `man snprintf'.
+ va_end(ap);
+ if (l + 1 > s->m - s->l) {
+ s->m = s->l + l + 2;
+ kroundup32(s->m);
+ s->s = (char*)realloc(s->s, s->m);
+ va_start(ap, fmt);
+ l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap);
+ }
+ va_end(ap);
+ s->l += l;
+ return l;
+}
+
+char *kstrtok(const char *str, const char *sep, ks_tokaux_t *aux)
+{
+ const char *p, *start;
+ if (sep) { // set up the table
+ if (str == 0 && (aux->tab[0]&1)) return 0; // no need to set up if we have finished
+ aux->finished = 0;
+ if (sep[1]) {
+ aux->sep = -1;
+ aux->tab[0] = aux->tab[1] = aux->tab[2] = aux->tab[3] = 0;
+ for (p = sep; *p; ++p) aux->tab[*p>>6] |= 1ull<<(*p&0x3f);
+ } else aux->sep = sep[0];
+ }
+ if (aux->finished) return 0;
+ else if (str) aux->p = str - 1, aux->finished = 0;
+ if (aux->sep < 0) {
+ for (p = start = aux->p + 1; *p; ++p)
+ if (aux->tab[*p>>6]>>(*p&0x3f)&1) break;
+ } else {
+ for (p = start = aux->p + 1; *p; ++p)
+ if (*p == aux->sep) break;
+ }
+ aux->p = p; // end of token
+ if (*p == 0) aux->finished = 1; // no more tokens
+ return (char*)start;
+}
+
+// s MUST BE a null terminated string; l = strlen(s)
+int ksplit_core(char *s, int delimiter, int *_max, int **_offsets)
+{
+ int i, n, max, last_char, last_start, *offsets, l;
+ n = 0; max = *_max; offsets = *_offsets;
+ l = strlen(s);
+
+#define __ksplit_aux do { \
+ if (_offsets) { \
+ s[i] = 0; \
+ if (n == max) { \
+ max = max? max<<1 : 2; \
+ offsets = (int*)realloc(offsets, sizeof(int) * max); \
+ } \
+ offsets[n++] = last_start; \
+ } else ++n; \
+ } while (0)
+
+ for (i = 0, last_char = last_start = 0; i <= l; ++i) {
+ if (delimiter == 0) {
+ if (isspace(s[i]) || s[i] == 0) {
+ if (isgraph(last_char)) __ksplit_aux; // the end of a field
+ } else {
+ if (isspace(last_char) || last_char == 0) last_start = i;
+ }
+ } else {
+ if (s[i] == delimiter || s[i] == 0) {
+ if (last_char != 0 && last_char != delimiter) __ksplit_aux; // the end of a field
+ } else {
+ if (last_char == delimiter || last_char == 0) last_start = i;
+ }
+ }
+ last_char = s[i];
+ }
+ *_max = max; *_offsets = offsets;
+ return n;
+}
+
+/**********************
+ * Boyer-Moore search *
+ **********************/
+
+typedef unsigned char ubyte_t;
+
+// reference: http://www-igm.univ-mlv.fr/~lecroq/string/node14.html
+static int *ksBM_prep(const ubyte_t *pat, int m)
+{
+ int i, *suff, *prep, *bmGs, *bmBc;
+ prep = calloc(m + 256, sizeof(int));
+ bmGs = prep; bmBc = prep + m;
+ { // preBmBc()
+ for (i = 0; i < 256; ++i) bmBc[i] = m;
+ for (i = 0; i < m - 1; ++i) bmBc[pat[i]] = m - i - 1;
+ }
+ suff = calloc(m, sizeof(int));
+ { // suffixes()
+ int f = 0, g;
+ suff[m - 1] = m;
+ g = m - 1;
+ for (i = m - 2; i >= 0; --i) {
+ if (i > g && suff[i + m - 1 - f] < i - g)
+ suff[i] = suff[i + m - 1 - f];
+ else {
+ if (i < g) g = i;
+ f = i;
+ while (g >= 0 && pat[g] == pat[g + m - 1 - f]) --g;
+ suff[i] = f - g;
+ }
+ }
+ }
+ { // preBmGs()
+ int j = 0;
+ for (i = 0; i < m; ++i) bmGs[i] = m;
+ for (i = m - 1; i >= 0; --i)
+ if (suff[i] == i + 1)
+ for (; j < m - 1 - i; ++j)
+ if (bmGs[j] == m)
+ bmGs[j] = m - 1 - i;
+ for (i = 0; i <= m - 2; ++i)
+ bmGs[m - 1 - suff[i]] = m - 1 - i;
+ }
+ free(suff);
+ return prep;
+}
+
+void *kmemmem(const void *_str, int n, const void *_pat, int m, int **_prep)
+{
+ int i, j, *prep = 0, *bmGs, *bmBc;
+ const ubyte_t *str, *pat;
+ str = (const ubyte_t*)_str; pat = (const ubyte_t*)_pat;
+ prep = (_prep == 0 || *_prep == 0)? ksBM_prep(pat, m) : *_prep;
+ if (_prep && *_prep == 0) *_prep = prep;
+ bmGs = prep; bmBc = prep + m;
+ j = 0;
+ while (j <= n - m) {
+ for (i = m - 1; i >= 0 && pat[i] == str[i+j]; --i);
+ if (i >= 0) {
+ int max = bmBc[str[i+j]] - m + 1 + i;
+ if (max < bmGs[i]) max = bmGs[i];
+ j += max;
+ } else return (void*)(str + j);
+ }
+ if (_prep == 0) free(prep);
+ return 0;
+}
+
+char *kstrstr(const char *str, const char *pat, int **_prep)
+{
+ return (char*)kmemmem(str, strlen(str), pat, strlen(pat), _prep);
+}
+
+char *kstrnstr(const char *str, const char *pat, int n, int **_prep)
+{
+ return (char*)kmemmem(str, n, pat, strlen(pat), _prep);
+}
+
+/***********************
+ * The main() function *
+ ***********************/
+
+#ifdef KSTRING_MAIN
+#include <stdio.h>
+int main()
+{
+ kstring_t *s;
+ int *fields, n, i;
+ ks_tokaux_t aux;
+ char *p;
+ s = (kstring_t*)calloc(1, sizeof(kstring_t));
+ // test ksprintf()
+ ksprintf(s, " abcdefg: %d ", 100);
+ printf("'%s'\n", s->s);
+ // test ksplit()
+ fields = ksplit(s, 0, &n);
+ for (i = 0; i < n; ++i)
+ printf("field[%d] = '%s'\n", i, s->s + fields[i]);
+ // test kstrtok()
+ s->l = 0;
+ for (p = kstrtok("ab:cde:fg/hij::k", ":/", &aux); p; p = kstrtok(0, 0, &aux)) {
+ kputsn(p, aux.p - p, s);
+ kputc('\n', s);
+ }
+ printf("%s", s->s);
+ // free
+ free(s->s); free(s); free(fields);
+
+ {
+ static char *str = "abcdefgcdgcagtcakcdcd";
+ static char *pat = "cd";
+ char *ret, *s = str;
+ int *prep = 0;
+ while ((ret = kstrstr(s, pat, &prep)) != 0) {
+ printf("match: %s\n", ret);
+ s = ret + prep[0];
+ }
+ free(prep);
+ }
+ return 0;
+}
+#endif
} kstring_t;
#endif
-int ksprintf(kstring_t *s, const char *fmt, ...);
-int ksplit_core(char *s, int delimiter, int *_max, int **_offsets);
+typedef struct {
+ uint64_t tab[4];
+ int sep, finished;
+ const char *p; // end of the current token
+} ks_tokaux_t;
-// calculate the auxiliary array, allocated by calloc()
-int *ksBM_prep(const uint8_t *pat, int m);
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+ int ksprintf(kstring_t *s, const char *fmt, ...);
+ int ksplit_core(char *s, int delimiter, int *_max, int **_offsets);
+ char *kstrstr(const char *str, const char *pat, int **_prep);
+ char *kstrnstr(const char *str, const char *pat, int n, int **_prep);
+ void *kmemmem(const void *_str, int n, const void *_pat, int m, int **_prep);
-/* Search pat in str and returned the list of matches. The size of the
- * list is returned as n_matches. _prep is the array returned by
- * ksBM_prep(). If it is a NULL pointer, ksBM_prep() will be called. */
-int *ksBM_search(const uint8_t *str, int n, const uint8_t *pat, int m, int *_prep, int *n_matches);
+ /* kstrtok() is similar to strtok_r() except that str is not
+ * modified and both str and sep can be NULL. For efficiency, it is
+ * actually recommended to set both to NULL in the subsequent calls
+ * if sep is not changed. */
+ char *kstrtok(const char *str, const char *sep, ks_tokaux_t *aux);
+#ifdef __cplusplus
+}
+#endif
+
static inline int kputsn(const char *p, int l, kstring_t *s)
{
if (s->l + l + 1 >= s->m) {
kroundup32(s->m);
s->s = (char*)realloc(s->s, s->m);
}
- strncpy(s->s + s->l, p, l);
+ memcpy(s->s + s->l, p, l);
s->l += l;
s->s[s->l] = 0;
return l;
--- /dev/null
+#include "pysam.h"
+
+/*
+ * This code implements the MD5 message-digest algorithm.
+ * The algorithm is due to Ron Rivest. This code was
+ * written by Colin Plumb in 1993, no copyright is claimed.
+ * This code is in the public domain; do with it what you wish.
+ *
+ * Equivalent code is available from RSA Data Security, Inc.
+ * This code has been tested against that, and is equivalent,
+ * except that you don't need to include two pages of legalese
+ * with every copy.
+ *
+ * To compute the message digest of a chunk of bytes, declare an
+ * MD5Context structure, pass it to MD5Init, call MD5Update as
+ * needed on buffers full of bytes, and then call MD5Final, which
+ * will fill a supplied 16-byte array with the digest.
+ */
+
+/* Brutally hacked by John Walker back from ANSI C to K&R (no
+ prototypes) to maintain the tradition that Netfone will compile
+ with Sun's original "cc". */
+
+#include <string.h>
+#include "md5.h"
+
+#ifndef HIGHFIRST
+#define byteReverse(buf, len) /* Nothing */
+#else
+/*
+ * Note: this code is harmless on little-endian machines.
+ */
+void byteReverse(buf, longs)
+ unsigned char *buf; unsigned longs;
+{
+ uint32_t t;
+ do {
+ t = (uint32_t) ((unsigned) buf[3] << 8 | buf[2]) << 16 |
+ ((unsigned) buf[1] << 8 | buf[0]);
+ *(uint32_t *) buf = t;
+ buf += 4;
+ } while (--longs);
+}
+#endif
+
+void MD5Transform(uint32_t buf[4], uint32_t in[16]);
+
+
+/*
+ * Start MD5 accumulation. Set bit count to 0 and buffer to mysterious
+ * initialization constants.
+ */
+void MD5Init(ctx)
+ struct MD5Context *ctx;
+{
+ ctx->buf[0] = 0x67452301;
+ ctx->buf[1] = 0xefcdab89;
+ ctx->buf[2] = 0x98badcfe;
+ ctx->buf[3] = 0x10325476;
+
+ ctx->bits[0] = 0;
+ ctx->bits[1] = 0;
+}
+
+/*
+ * Update context to reflect the concatenation of another buffer full
+ * of bytes.
+ */
+void MD5Update(ctx, buf, len)
+ struct MD5Context *ctx; unsigned char *buf; unsigned len;
+{
+ uint32_t t;
+
+ /* Update bitcount */
+
+ t = ctx->bits[0];
+ if ((ctx->bits[0] = t + ((uint32_t) len << 3)) < t)
+ ctx->bits[1]++; /* Carry from low to high */
+ ctx->bits[1] += len >> 29;
+
+ t = (t >> 3) & 0x3f; /* Bytes already in shsInfo->data */
+
+ /* Handle any leading odd-sized chunks */
+
+ if (t) {
+ unsigned char *p = (unsigned char *) ctx->in + t;
+
+ t = 64 - t;
+ if (len < t) {
+ memcpy(p, buf, len);
+ return;
+ }
+ memcpy(p, buf, t);
+ byteReverse(ctx->in, 16);
+ MD5Transform(ctx->buf, (uint32_t *) ctx->in);
+ buf += t;
+ len -= t;
+ }
+ /* Process data in 64-byte chunks */
+
+ while (len >= 64) {
+ memcpy(ctx->in, buf, 64);
+ byteReverse(ctx->in, 16);
+ MD5Transform(ctx->buf, (uint32_t *) ctx->in);
+ buf += 64;
+ len -= 64;
+ }
+
+ /* Handle any remaining bytes of data. */
+
+ memcpy(ctx->in, buf, len);
+}
+
+/*
+ * Final wrapup - pad to 64-byte boundary with the bit pattern
+ * 1 0* (64-bit count of bits processed, MSB-first)
+ */
+void MD5Final(digest, ctx)
+ unsigned char digest[16]; struct MD5Context *ctx;
+{
+ unsigned count;
+ unsigned char *p;
+
+ /* Compute number of bytes mod 64 */
+ count = (ctx->bits[0] >> 3) & 0x3F;
+
+ /* Set the first char of padding to 0x80. This is safe since there is
+ always at least one byte free */
+ p = ctx->in + count;
+ *p++ = 0x80;
+
+ /* Bytes of padding needed to make 64 bytes */
+ count = 64 - 1 - count;
+
+ /* Pad out to 56 mod 64 */
+ if (count < 8) {
+ /* Two lots of padding: Pad the first block to 64 bytes */
+ memset(p, 0, count);
+ byteReverse(ctx->in, 16);
+ MD5Transform(ctx->buf, (uint32_t *) ctx->in);
+
+ /* Now fill the next block with 56 bytes */
+ memset(ctx->in, 0, 56);
+ } else {
+ /* Pad block to 56 bytes */
+ memset(p, 0, count - 8);
+ }
+ byteReverse(ctx->in, 14);
+
+ /* Append length in bits and transform */
+ ((uint32_t *) ctx->in)[14] = ctx->bits[0];
+ ((uint32_t *) ctx->in)[15] = ctx->bits[1];
+
+ MD5Transform(ctx->buf, (uint32_t *) ctx->in);
+ byteReverse((unsigned char *) ctx->buf, 4);
+ memcpy(digest, ctx->buf, 16);
+ memset(ctx, 0, sizeof(ctx)); /* In case it's sensitive */
+}
+
+
+/* The four core functions - F1 is optimized somewhat */
+
+/* #define F1(x, y, z) (x & y | ~x & z) */
+#define F1(x, y, z) (z ^ (x & (y ^ z)))
+#define F2(x, y, z) F1(z, x, y)
+#define F3(x, y, z) (x ^ y ^ z)
+#define F4(x, y, z) (y ^ (x | ~z))
+
+/* This is the central step in the MD5 algorithm. */
+#define MD5STEP(f, w, x, y, z, data, s) \
+ ( w += f(x, y, z) + data, w = w<<s | w>>(32-s), w += x )
+
+/*
+ * The core of the MD5 algorithm, this alters an existing MD5 hash to
+ * reflect the addition of 16 longwords of new data. MD5Update blocks
+ * the data and converts bytes into longwords for this routine.
+ */
+void MD5Transform(buf, in)
+ uint32_t buf[4]; uint32_t in[16];
+{
+ register uint32_t a, b, c, d;
+
+ a = buf[0];
+ b = buf[1];
+ c = buf[2];
+ d = buf[3];
+
+ MD5STEP(F1, a, b, c, d, in[0] + 0xd76aa478, 7);
+ MD5STEP(F1, d, a, b, c, in[1] + 0xe8c7b756, 12);
+ MD5STEP(F1, c, d, a, b, in[2] + 0x242070db, 17);
+ MD5STEP(F1, b, c, d, a, in[3] + 0xc1bdceee, 22);
+ MD5STEP(F1, a, b, c, d, in[4] + 0xf57c0faf, 7);
+ MD5STEP(F1, d, a, b, c, in[5] + 0x4787c62a, 12);
+ MD5STEP(F1, c, d, a, b, in[6] + 0xa8304613, 17);
+ MD5STEP(F1, b, c, d, a, in[7] + 0xfd469501, 22);
+ MD5STEP(F1, a, b, c, d, in[8] + 0x698098d8, 7);
+ MD5STEP(F1, d, a, b, c, in[9] + 0x8b44f7af, 12);
+ MD5STEP(F1, c, d, a, b, in[10] + 0xffff5bb1, 17);
+ MD5STEP(F1, b, c, d, a, in[11] + 0x895cd7be, 22);
+ MD5STEP(F1, a, b, c, d, in[12] + 0x6b901122, 7);
+ MD5STEP(F1, d, a, b, c, in[13] + 0xfd987193, 12);
+ MD5STEP(F1, c, d, a, b, in[14] + 0xa679438e, 17);
+ MD5STEP(F1, b, c, d, a, in[15] + 0x49b40821, 22);
+
+ MD5STEP(F2, a, b, c, d, in[1] + 0xf61e2562, 5);
+ MD5STEP(F2, d, a, b, c, in[6] + 0xc040b340, 9);
+ MD5STEP(F2, c, d, a, b, in[11] + 0x265e5a51, 14);
+ MD5STEP(F2, b, c, d, a, in[0] + 0xe9b6c7aa, 20);
+ MD5STEP(F2, a, b, c, d, in[5] + 0xd62f105d, 5);
+ MD5STEP(F2, d, a, b, c, in[10] + 0x02441453, 9);
+ MD5STEP(F2, c, d, a, b, in[15] + 0xd8a1e681, 14);
+ MD5STEP(F2, b, c, d, a, in[4] + 0xe7d3fbc8, 20);
+ MD5STEP(F2, a, b, c, d, in[9] + 0x21e1cde6, 5);
+ MD5STEP(F2, d, a, b, c, in[14] + 0xc33707d6, 9);
+ MD5STEP(F2, c, d, a, b, in[3] + 0xf4d50d87, 14);
+ MD5STEP(F2, b, c, d, a, in[8] + 0x455a14ed, 20);
+ MD5STEP(F2, a, b, c, d, in[13] + 0xa9e3e905, 5);
+ MD5STEP(F2, d, a, b, c, in[2] + 0xfcefa3f8, 9);
+ MD5STEP(F2, c, d, a, b, in[7] + 0x676f02d9, 14);
+ MD5STEP(F2, b, c, d, a, in[12] + 0x8d2a4c8a, 20);
+
+ MD5STEP(F3, a, b, c, d, in[5] + 0xfffa3942, 4);
+ MD5STEP(F3, d, a, b, c, in[8] + 0x8771f681, 11);
+ MD5STEP(F3, c, d, a, b, in[11] + 0x6d9d6122, 16);
+ MD5STEP(F3, b, c, d, a, in[14] + 0xfde5380c, 23);
+ MD5STEP(F3, a, b, c, d, in[1] + 0xa4beea44, 4);
+ MD5STEP(F3, d, a, b, c, in[4] + 0x4bdecfa9, 11);
+ MD5STEP(F3, c, d, a, b, in[7] + 0xf6bb4b60, 16);
+ MD5STEP(F3, b, c, d, a, in[10] + 0xbebfbc70, 23);
+ MD5STEP(F3, a, b, c, d, in[13] + 0x289b7ec6, 4);
+ MD5STEP(F3, d, a, b, c, in[0] + 0xeaa127fa, 11);
+ MD5STEP(F3, c, d, a, b, in[3] + 0xd4ef3085, 16);
+ MD5STEP(F3, b, c, d, a, in[6] + 0x04881d05, 23);
+ MD5STEP(F3, a, b, c, d, in[9] + 0xd9d4d039, 4);
+ MD5STEP(F3, d, a, b, c, in[12] + 0xe6db99e5, 11);
+ MD5STEP(F3, c, d, a, b, in[15] + 0x1fa27cf8, 16);
+ MD5STEP(F3, b, c, d, a, in[2] + 0xc4ac5665, 23);
+
+ MD5STEP(F4, a, b, c, d, in[0] + 0xf4292244, 6);
+ MD5STEP(F4, d, a, b, c, in[7] + 0x432aff97, 10);
+ MD5STEP(F4, c, d, a, b, in[14] + 0xab9423a7, 15);
+ MD5STEP(F4, b, c, d, a, in[5] + 0xfc93a039, 21);
+ MD5STEP(F4, a, b, c, d, in[12] + 0x655b59c3, 6);
+ MD5STEP(F4, d, a, b, c, in[3] + 0x8f0ccc92, 10);
+ MD5STEP(F4, c, d, a, b, in[10] + 0xffeff47d, 15);
+ MD5STEP(F4, b, c, d, a, in[1] + 0x85845dd1, 21);
+ MD5STEP(F4, a, b, c, d, in[8] + 0x6fa87e4f, 6);
+ MD5STEP(F4, d, a, b, c, in[15] + 0xfe2ce6e0, 10);
+ MD5STEP(F4, c, d, a, b, in[6] + 0xa3014314, 15);
+ MD5STEP(F4, b, c, d, a, in[13] + 0x4e0811a1, 21);
+ MD5STEP(F4, a, b, c, d, in[4] + 0xf7537e82, 6);
+ MD5STEP(F4, d, a, b, c, in[11] + 0xbd3af235, 10);
+ MD5STEP(F4, c, d, a, b, in[2] + 0x2ad7d2bb, 15);
+ MD5STEP(F4, b, c, d, a, in[9] + 0xeb86d391, 21);
+
+ buf[0] += a;
+ buf[1] += b;
+ buf[2] += c;
+ buf[3] += d;
+}
+
+/* lh3: the following code is added by me */
+
+#ifdef MD5SUM_MAIN
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+#define HEX_STR "0123456789abcdef"
+
+static void md5_one(const char *fn)
+{
+ unsigned char buf[4096], digest[16];
+ MD5_CTX md5;
+ int l;
+ FILE *fp;
+
+ fp = strcmp(fn, "-")? fopen(fn, "r") : stdin;
+ if (fp == 0) {
+ fprintf(pysamerr, "md5sum: %s: No such file or directory\n", fn);
+ exit(1);
+ }
+ MD5Init(&md5);
+ while ((l = fread(buf, 1, 4096, fp)) > 0)
+ MD5Update(&md5, buf, l);
+ MD5Final(digest, &md5);
+ if (fp != stdin) fclose(fp);
+ for (l = 0; l < 16; ++l)
+ printf("%c%c", HEX_STR[digest[l]>>4&0xf], HEX_STR[digest[l]&0xf]);
+ printf(" %s\n", fn);
+}
+int main(int argc, char *argv[])
+{
+ int i;
+ if (argc == 1) md5_one("-");
+ else for (i = 1; i < argc; ++i) md5_one(argv[i]);
+ return 0;
+}
+#endif
--- /dev/null
+/*
+ This file is adapted from a program in this page:
+
+ http://www.fourmilab.ch/md5/
+
+ The original source code does not work on 64-bit machines due to the
+ wrong typedef "uint32". I also added prototypes.
+
+ -lh3
+ */
+
+#ifndef MD5_H
+#define MD5_H
+
+/* The following tests optimise behaviour on little-endian
+ machines, where there is no need to reverse the byte order
+ of 32 bit words in the MD5 computation. By default,
+ HIGHFIRST is defined, which indicates we're running on a
+ big-endian (most significant byte first) machine, on which
+ the byteReverse function in md5.c must be invoked. However,
+ byteReverse is coded in such a way that it is an identity
+ function when run on a little-endian machine, so calling it
+ on such a platform causes no harm apart from wasting time.
+ If the platform is known to be little-endian, we speed
+ things up by undefining HIGHFIRST, which defines
+ byteReverse as a null macro. Doing things in this manner
+ insures we work on new platforms regardless of their byte
+ order. */
+
+#define HIGHFIRST
+
+#if __LITTLE_ENDIAN__ != 0
+#undef HIGHFIRST
+#endif
+
+#include <stdint.h>
+
+struct MD5Context {
+ uint32_t buf[4];
+ uint32_t bits[2];
+ unsigned char in[64];
+};
+
+void MD5Init(struct MD5Context *ctx);
+void MD5Update(struct MD5Context *ctx, unsigned char *buf, unsigned len);
+void MD5Final(unsigned char digest[16], struct MD5Context *ctx);
+
+/*
+ * This is needed to make RSAREF happy on some MS-DOS compilers.
+ */
+typedef struct MD5Context MD5_CTX;
+
+/* Define CHECK_HARDWARE_PROPERTIES to have main,c verify
+ byte order and uint32_t settings. */
+#define CHECK_HARDWARE_PROPERTIES
+
+#endif /* !MD5_H */
--- /dev/null
+// Windows-specific code, include with:\r
+// #ifdef _MSC_VER\r
+// #include <msvc_compat.h>\r
+// #endif\r
+\r
+//#define _CRT_SECURE_NO_WARNINGS\r
+#ifndef MSVC_COMPAT_H\r
+#define MSVC_COMPAT_H\r
+\r
+#define inline __inline\r
+#define __func__ __FUNCTION__\r
+\r
+#include <float.h>\r
+#define isnan _isnan\r
+static int isinf(double x) {\r
+ int y = _finite(x);\r
+ if(y == 0) {\r
+ return 0;\r
+ } else {\r
+ return 1;\r
+ }\r
+}\r
+#define alloca _alloca\r
+#define atoll _atoi64\r
+\r
+#define ftello ftell\r
+
+typedef int bool;\r
+\r
+static int R_OK = 4;
+\r
+#ifndef lgamma\r
+/* Log gamma function\r
+ * \log{\Gamma(z)}\r
+ * AS245, 2nd algorithm, http://lib.stat.cmu.edu/apstat/245\r
+ */\r
+static double lgamma(double z)\r
+{\r
+ double x = 0;\r
+ x += 0.1659470187408462e-06 / (z+7);\r
+ x += 0.9934937113930748e-05 / (z+6);\r
+ x -= 0.1385710331296526 / (z+5);\r
+ x += 12.50734324009056 / (z+4);\r
+ x -= 176.6150291498386 / (z+3);\r
+ x += 771.3234287757674 / (z+2);\r
+ x -= 1259.139216722289 / (z+1);\r
+ x += 676.5203681218835 / z;\r
+ x += 0.9999999999995183;\r
+ return log(x) - 5.58106146679532777 - z + (z-0.5) * log(z+6.5);\r
+}\r
+#endif\r
+\r
+#ifndef M_LN10\r
+#define M_LN10 2.30258509299404568402\r
+#endif\r
+#ifndef M_LN2\r
+#define M_LN2 0.69314718055994530942\r
+#endif\r
+
+#endif\r
--- /dev/null
+#include "pysam.h"
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <unistd.h>
+#include <stdint.h>
+#include <math.h>
+#include <zlib.h>
+#include "bam.h"
+#include "errmod.h"
+
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 16384)
+
+#define MAX_VARS 256
+#define FLIP_PENALTY 2
+#define FLIP_THRES 4
+#define MASK_THRES 3
+
+#define FLAG_FIX_CHIMERA 0x1
+#define FLAG_LIST_EXCL 0x4
+#define FLAG_DROP_AMBI 0x8
+
+typedef struct {
+ // configurations, initialized in the main function
+ int flag, k, min_baseQ, min_varLOD, max_depth;
+ // other global variables
+ int vpos_shift;
+ bamFile fp;
+ char *pre;
+ bamFile out[3];
+ // alignment queue
+ int n, m;
+ bam1_t **b;
+} phaseg_t;
+
+typedef struct {
+ int8_t seq[MAX_VARS]; // TODO: change to dynamic memory allocation!
+ int vpos, beg, end;
+ uint32_t vlen:16, single:1, flip:1, phase:1, phased:1, ambig:1;
+ uint32_t in:16, out:16; // in-phase and out-phase
+} frag_t, *frag_p;
+
+#define rseq_lt(a,b) ((a)->vpos < (b)->vpos)
+
+#include "khash.h"
+KHASH_SET_INIT_INT64(set64)
+KHASH_MAP_INIT_INT64(64, frag_t)
+
+typedef khash_t(64) nseq_t;
+
+#include "ksort.h"
+KSORT_INIT(rseq, frag_p, rseq_lt)
+
+static char nt16_nt4_table[] = { 4, 0, 1, 4, 2, 4, 4, 4, 3, 4, 4, 4, 4, 4, 4, 4 };
+
+static inline uint64_t X31_hash_string(const char *s)
+{
+ uint64_t h = *s;
+ if (h) for (++s ; *s; ++s) h = (h << 5) - h + *s;
+ return h;
+}
+
+static void count1(int l, const uint8_t *seq, int *cnt)
+{
+ int i, j, n_ambi;
+ uint32_t z, x;
+ if (seq[l-1] == 0) return; // do nothing is the last base is ambiguous
+ for (i = n_ambi = 0; i < l; ++i) // collect ambiguous bases
+ if (seq[i] == 0) ++n_ambi;
+ if (l - n_ambi <= 1) return; // only one SNP
+ for (x = 0; x < 1u<<n_ambi; ++x) { // count
+ for (i = j = 0, z = 0; i < l; ++i) {
+ int c;
+ if (seq[i]) c = seq[i] - 1;
+ else {
+ c = x>>j&1;
+ ++j;
+ }
+ z = z<<1 | c;
+ }
+ ++cnt[z];
+ }
+}
+
+static int **count_all(int l, int vpos, nseq_t *hash)
+{
+ khint_t k;
+ int i, j, **cnt;
+ uint8_t *seq;
+ seq = calloc(l, 1);
+ cnt = calloc(vpos, sizeof(void*));
+ for (i = 0; i < vpos; ++i) cnt[i] = calloc(1<<l, sizeof(int));
+ for (k = 0; k < kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ frag_t *f = &kh_val(hash, k);
+ if (f->vpos >= vpos || f->single) continue; // out of region; or singleton
+ if (f->vlen == 1) { // such reads should be flagged as deleted previously if everything is right
+ f->single = 1;
+ continue;
+ }
+ for (j = 1; j < f->vlen; ++j) {
+ for (i = 0; i < l; ++i)
+ seq[i] = j < l - 1 - i? 0 : f->seq[j - (l - 1 - i)];
+ count1(l, seq, cnt[f->vpos + j]);
+ }
+ }
+ }
+ free(seq);
+ return cnt;
+}
+
+// phasing
+static int8_t *dynaprog(int l, int vpos, int **w)
+{
+ int *f[2], *curr, *prev, max, i;
+ int8_t **b, *h = 0;
+ uint32_t x, z = 1u<<(l-1), mask = (1u<<l) - 1;
+ f[0] = calloc(z, sizeof(int));
+ f[1] = calloc(z, sizeof(int));
+ b = calloc(vpos, sizeof(void*));
+ prev = f[0]; curr = f[1];
+ // fill the backtrack matrix
+ for (i = 0; i < vpos; ++i) {
+ int *wi = w[i], *tmp;
+ int8_t *bi;
+ bi = b[i] = calloc(z, 1);
+ /* In the following, x is the current state, which is the
+ * lexicographically smaller local haplotype. xc is the complement of
+ * x, or the larger local haplotype; y0 and y1 are the two predecessors
+ * of x. */
+ for (x = 0; x < z; ++x) { // x0 is the smaller
+ uint32_t y0, y1, xc;
+ int c0, c1;
+ xc = ~x&mask; y0 = x>>1; y1 = xc>>1;
+ c0 = prev[y0] + wi[x] + wi[xc];
+ c1 = prev[y1] + wi[x] + wi[xc];
+ if (c0 > c1) bi[x] = 0, curr[x] = c0;
+ else bi[x] = 1, curr[x] = c1;
+ }
+ tmp = prev; prev = curr; curr = tmp; // swap
+ }
+ { // backtrack
+ uint32_t max_x = 0;
+ int which = 0;
+ h = calloc(vpos, 1);
+ for (x = 0, max = 0, max_x = 0; x < z; ++x)
+ if (prev[x] > max) max = prev[x], max_x = x;
+ for (i = vpos - 1, x = max_x; i >= 0; --i) {
+ h[i] = which? (~x&1) : (x&1);
+ which = b[i][x]? !which : which;
+ x = b[i][x]? (~x&mask)>>1 : x>>1;
+ }
+ }
+ // free
+ for (i = 0; i < vpos; ++i) free(b[i]);
+ free(f[0]); free(f[1]); free(b);
+ return h;
+}
+
+// phase each fragment
+static uint64_t *fragphase(int vpos, const int8_t *path, nseq_t *hash, int flip)
+{
+ khint_t k;
+ uint64_t *pcnt;
+ uint32_t *left, *rght, max;
+ left = rght = 0; max = 0;
+ pcnt = calloc(vpos, 8);
+ for (k = 0; k < kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ int i, c[2];
+ frag_t *f = &kh_val(hash, k);
+ if (f->vpos >= vpos) continue;
+ // get the phase
+ c[0] = c[1] = 0;
+ for (i = 0; i < f->vlen; ++i) {
+ if (f->seq[i] == 0) continue;
+ ++c[f->seq[i] == path[f->vpos + i] + 1? 0 : 1];
+ }
+ f->phase = c[0] > c[1]? 0 : 1;
+ f->in = c[f->phase]; f->out = c[1 - f->phase];
+ f->phased = f->in == f->out? 0 : 1;
+ f->ambig = (f->in && f->out && f->out < 3 && f->in <= f->out + 1)? 1 : 0;
+ // fix chimera
+ f->flip = 0;
+ if (flip && c[0] >= 3 && c[1] >= 3) {
+ int sum[2], m, mi, md;
+ if (f->vlen > max) { // enlarge the array
+ max = f->vlen;
+ kroundup32(max);
+ left = realloc(left, max * 4);
+ rght = realloc(rght, max * 4);
+ }
+ for (i = 0, sum[0] = sum[1] = 0; i < f->vlen; ++i) { // get left counts
+ if (f->seq[i]) {
+ int c = f->phase? 2 - f->seq[i] : f->seq[i] - 1;
+ ++sum[c == path[f->vpos + i]? 0 : 1];
+ }
+ left[i] = sum[1]<<16 | sum[0];
+ }
+ for (i = f->vlen - 1, sum[0] = sum[1] = 0; i >= 0; --i) { // get right counts
+ if (f->seq[i]) {
+ int c = f->phase? 2 - f->seq[i] : f->seq[i] - 1;
+ ++sum[c == path[f->vpos + i]? 0 : 1];
+ }
+ rght[i] = sum[1]<<16 | sum[0];
+ }
+ // find the best flip point
+ for (i = m = 0, mi = -1, md = -1; i < f->vlen - 1; ++i) {
+ int a[2];
+ a[0] = (left[i]&0xffff) + (rght[i+1]>>16&0xffff) - (rght[i+1]&0xffff) * FLIP_PENALTY;
+ a[1] = (left[i]>>16&0xffff) + (rght[i+1]&0xffff) - (rght[i+1]>>16&0xffff) * FLIP_PENALTY;
+ if (a[0] > a[1]) {
+ if (a[0] > m) m = a[0], md = 0, mi = i;
+ } else {
+ if (a[1] > m) m = a[1], md = 1, mi = i;
+ }
+ }
+ if (m - c[0] >= FLIP_THRES && m - c[1] >= FLIP_THRES) { // then flip
+ f->flip = 1;
+ if (md == 0) { // flip the tail
+ for (i = mi + 1; i < f->vlen; ++i)
+ if (f->seq[i] == 1) f->seq[i] = 2;
+ else if (f->seq[i] == 2) f->seq[i] = 1;
+ } else { // flip the head
+ for (i = 0; i <= mi; ++i)
+ if (f->seq[i] == 1) f->seq[i] = 2;
+ else if (f->seq[i] == 2) f->seq[i] = 1;
+ }
+ }
+ }
+ // update pcnt[]
+ if (!f->single) {
+ for (i = 0; i < f->vlen; ++i) {
+ int c;
+ if (f->seq[i] == 0) continue;
+ c = f->phase? 2 - f->seq[i] : f->seq[i] - 1;
+ if (c == path[f->vpos + i]) {
+ if (f->phase == 0) ++pcnt[f->vpos + i];
+ else pcnt[f->vpos + i] += 1ull<<32;
+ } else {
+ if (f->phase == 0) pcnt[f->vpos + i] += 1<<16;
+ else pcnt[f->vpos + i] += 1ull<<48;
+ }
+ }
+ }
+ }
+ }
+ free(left); free(rght);
+ return pcnt;
+}
+
+static uint64_t *genmask(int vpos, const uint64_t *pcnt, int *_n)
+{
+ int i, max = 0, max_i = -1, m = 0, n = 0, beg = 0, score = 0;
+ uint64_t *list = 0;
+ for (i = 0; i < vpos; ++i) {
+ uint64_t x = pcnt[i];
+ int c[4], pre = score, s;
+ c[0] = x&0xffff; c[1] = x>>16&0xffff; c[2] = x>>32&0xffff; c[3] = x>>48&0xffff;
+ s = (c[1] + c[3] == 0)? -(c[0] + c[2]) : (c[1] + c[3] - 1);
+ if (c[3] > c[2]) s += c[3] - c[2];
+ if (c[1] > c[0]) s += c[1] - c[0];
+ score += s;
+ if (score < 0) score = 0;
+ if (pre == 0 && score > 0) beg = i; // change from zero to non-zero
+ if ((i == vpos - 1 || score == 0) && max >= MASK_THRES) {
+ if (n == m) {
+ m = m? m<<1 : 4;
+ list = realloc(list, m * 8);
+ }
+ list[n++] = (uint64_t)beg<<32 | max_i;
+ i = max_i; // reset i to max_i
+ score = 0;
+ } else if (score > max) max = score, max_i = i;
+ if (score == 0) max = 0;
+ }
+ *_n = n;
+ return list;
+}
+
+// trim heading and tailing ambiguous bases; mark deleted and remove sequence
+static int clean_seqs(int vpos, nseq_t *hash)
+{
+ khint_t k;
+ int ret = 0;
+ for (k = 0; k < kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ frag_t *f = &kh_val(hash, k);
+ int beg, end, i;
+ if (f->vpos >= vpos) {
+ ret = 1;
+ continue;
+ }
+ for (i = 0; i < f->vlen; ++i)
+ if (f->seq[i] != 0) break;
+ beg = i;
+ for (i = f->vlen - 1; i >= 0; --i)
+ if (f->seq[i] != 0) break;
+ end = i + 1;
+ if (end - beg <= 0) kh_del(64, hash, k);
+ else {
+ if (beg != 0) memmove(f->seq, f->seq + beg, end - beg);
+ f->vpos += beg; f->vlen = end - beg;
+ f->single = f->vlen == 1? 1 : 0;
+ }
+ }
+ }
+ return ret;
+}
+
+static void dump_aln(phaseg_t *g, int min_pos, const nseq_t *hash)
+{
+ int i, is_flip, drop_ambi;
+ drop_ambi = g->flag & FLAG_DROP_AMBI;
+ is_flip = (drand48() < 0.5);
+ for (i = 0; i < g->n; ++i) {
+ int end, which;
+ uint64_t key;
+ khint_t k;
+ bam1_t *b = g->b[i];
+ key = X31_hash_string(bam1_qname(b));
+ end = bam_calend(&b->core, bam1_cigar(b));
+ if (end > min_pos) break;
+ k = kh_get(64, hash, key);
+ if (k == kh_end(hash)) which = 3;
+ else {
+ frag_t *f = &kh_val(hash, k);
+ if (f->ambig) which = drop_ambi? 2 : 3;
+ else if (f->phased && f->flip) which = 2;
+ else if (f->phased == 0) which = 3;
+ else { // phased and not flipped
+ char c = 'Y';
+ which = f->phase;
+ bam_aux_append(b, "ZP", 'A', 1, (uint8_t*)&c);
+ }
+ if (which < 2 && is_flip) which = 1 - which; // increase the randomness
+ }
+ if (which == 3) which = (drand48() < 0.5);
+ bam_write1(g->out[which], b);
+ bam_destroy1(b);
+ g->b[i] = 0;
+ }
+ memmove(g->b, g->b + i, (g->n - i) * sizeof(void*));
+ g->n -= i;
+}
+
+static int phase(phaseg_t *g, const char *chr, int vpos, uint64_t *cns, nseq_t *hash)
+{
+ int i, j, n_seqs = kh_size(hash), n_masked = 0, min_pos;
+ khint_t k;
+ frag_t **seqs;
+ int8_t *path, *sitemask;
+ uint64_t *pcnt, *regmask;
+
+ if (vpos == 0) return 0;
+ i = clean_seqs(vpos, hash); // i is true if hash has an element with its vpos >= vpos
+ min_pos = i? cns[vpos]>>32 : 0x7fffffff;
+ if (vpos == 1) {
+ printf("PS\t%s\t%d\t%d\n", chr, (int)(cns[0]>>32) + 1, (int)(cns[0]>>32) + 1);
+ printf("M0\t%s\t%d\t%d\t%c\t%c\t%d\t0\t0\t0\t0\n//\n", chr, (int)(cns[0]>>32) + 1, (int)(cns[0]>>32) + 1,
+ "ACGTX"[cns[0]&3], "ACGTX"[cns[0]>>16&3], g->vpos_shift + 1);
+ for (k = 0; k < kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ frag_t *f = &kh_val(hash, k);
+ if (f->vpos) continue;
+ f->flip = 0;
+ if (f->seq[0] == 0) f->phased = 0;
+ else f->phased = 1, f->phase = f->seq[0] - 1;
+ }
+ }
+ dump_aln(g, min_pos, hash);
+ ++g->vpos_shift;
+ return 1;
+ }
+ { // phase
+ int **cnt;
+ uint64_t *mask;
+ printf("PS\t%s\t%d\t%d\n", chr, (int)(cns[0]>>32) + 1, (int)(cns[vpos-1]>>32) + 1);
+ sitemask = calloc(vpos, 1);
+ cnt = count_all(g->k, vpos, hash);
+ path = dynaprog(g->k, vpos, cnt);
+ for (i = 0; i < vpos; ++i) free(cnt[i]);
+ free(cnt);
+ pcnt = fragphase(vpos, path, hash, 0); // do not fix chimeras when masking
+ mask = genmask(vpos, pcnt, &n_masked);
+ regmask = calloc(n_masked, 8);
+ for (i = 0; i < n_masked; ++i) {
+ regmask[i] = cns[mask[i]>>32]>>32<<32 | cns[(uint32_t)mask[i]]>>32;
+ for (j = mask[i]>>32; j <= (int32_t)mask[i]; ++j)
+ sitemask[j] = 1;
+ }
+ free(mask);
+ if (g->flag & FLAG_FIX_CHIMERA) {
+ free(pcnt);
+ pcnt = fragphase(vpos, path, hash, 1);
+ }
+ }
+ for (i = 0; i < n_masked; ++i)
+ printf("FL\t%s\t%d\t%d\n", chr, (int)(regmask[i]>>32) + 1, (int)regmask[i] + 1);
+ for (i = 0; i < vpos; ++i) {
+ uint64_t x = pcnt[i];
+ int8_t c[2];
+ c[0] = (cns[i]&0xffff)>>2 == 0? 4 : (cns[i]&3);
+ c[1] = (cns[i]>>16&0xffff)>>2 == 0? 4 : (cns[i]>>16&3);
+ printf("M%d\t%s\t%d\t%d\t%c\t%c\t%d\t%d\t%d\t%d\t%d\n", sitemask[i]+1, chr, (int)(cns[0]>>32) + 1, (int)(cns[i]>>32) + 1, "ACGTX"[c[path[i]]], "ACGTX"[c[1-path[i]]],
+ i + g->vpos_shift + 1, (int)(x&0xffff), (int)(x>>16&0xffff), (int)(x>>32&0xffff), (int)(x>>48&0xffff));
+ }
+ free(path); free(pcnt); free(regmask); free(sitemask);
+ seqs = calloc(n_seqs, sizeof(void*));
+ for (k = 0, i = 0; k < kh_end(hash); ++k)
+ if (kh_exist(hash, k) && kh_val(hash, k).vpos < vpos && !kh_val(hash, k).single)
+ seqs[i++] = &kh_val(hash, k);
+ n_seqs = i;
+ ks_introsort_rseq(n_seqs, seqs);
+ for (i = 0; i < n_seqs; ++i) {
+ frag_t *f = seqs[i];
+ printf("EV\t0\t%s\t%d\t40\t%dM\t*\t0\t0\t", chr, f->vpos + 1 + g->vpos_shift, f->vlen);
+ for (j = 0; j < f->vlen; ++j) {
+ uint32_t c = cns[f->vpos + j];
+ if (f->seq[j] == 0) putchar('N');
+ else putchar("ACGT"[f->seq[j] == 1? (c&3) : (c>>16&3)]);
+ }
+ printf("\t*\tYP:i:%d\tYF:i:%d\tYI:i:%d\tYO:i:%d\tYS:i:%d\n", f->phase, f->flip, f->in, f->out, f->beg+1);
+ }
+ free(seqs);
+ printf("//\n");
+ fflush(stdout);
+ g->vpos_shift += vpos;
+ dump_aln(g, min_pos, hash);
+ return vpos;
+}
+
+static void update_vpos(int vpos, nseq_t *hash)
+{
+ khint_t k;
+ for (k = 0; k < kh_end(hash); ++k) {
+ if (kh_exist(hash, k)) {
+ frag_t *f = &kh_val(hash, k);
+ if (f->vpos < vpos) kh_del(64, hash, k); // TODO: if frag_t::seq is allocated dynamically, free it
+ else f->vpos -= vpos;
+ }
+ }
+}
+
+static nseq_t *shrink_hash(nseq_t *hash) // TODO: to implement
+{
+ return hash;
+}
+
+static int readaln(void *data, bam1_t *b)
+{
+ phaseg_t *g = (phaseg_t*)data;
+ int ret;
+ ret = bam_read1(g->fp, b);
+ if (ret < 0) return ret;
+ if (!(b->core.flag & (BAM_FUNMAP|BAM_FSECONDARY|BAM_FQCFAIL|BAM_FDUP)) && g->pre) {
+ if (g->n == g->m) {
+ g->m = g->m? g->m<<1 : 16;
+ g->b = realloc(g->b, g->m * sizeof(void*));
+ }
+ g->b[g->n++] = bam_dup1(b);
+ }
+ return ret;
+}
+
+static khash_t(set64) *loadpos(const char *fn, bam_header_t *h)
+{
+ gzFile fp;
+ kstream_t *ks;
+ int ret, dret;
+ kstring_t *str;
+ khash_t(set64) *hash;
+
+ hash = kh_init(set64);
+ str = calloc(1, sizeof(kstring_t));
+ fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, 0, str, &dret) >= 0) {
+ int tid = bam_get_tid(h, str->s);
+ if (tid >= 0 && dret != '\n') {
+ if (ks_getuntil(ks, 0, str, &dret) >= 0) {
+ uint64_t x = (uint64_t)tid<<32 | (atoi(str->s) - 1);
+ kh_put(set64, hash, x, &ret);
+ } else break;
+ }
+ if (dret != '\n') while ((dret = ks_getc(ks)) > 0 && dret != '\n');
+ if (dret < 0) break;
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(str->s); free(str);
+ return hash;
+}
+
+static int gl2cns(float q[16])
+{
+ int i, j, min_ij;
+ float min, min2;
+ min = min2 = 1e30; min_ij = -1;
+ for (i = 0; i < 4; ++i) {
+ for (j = i; j < 4; ++j) {
+ if (q[i<<2|j] < min) min_ij = i<<2|j, min2 = min, min = q[i<<2|j];
+ else if (q[i<<2|j] < min2) min2 = q[i<<2|j];
+ }
+ }
+ return (min_ij>>2&3) == (min_ij&3)? 0 : 1<<18 | (min_ij>>2&3)<<16 | (min_ij&3) | (int)(min2 - min + .499) << 2;
+}
+
+int main_phase(int argc, char *argv[])
+{
+ extern void bam_init_header_hash(bam_header_t *header);
+ int c, tid, pos, vpos = 0, n, lasttid = -1, max_vpos = 0;
+ const bam_pileup1_t *plp;
+ bam_plp_t iter;
+ bam_header_t *h;
+ nseq_t *seqs;
+ uint64_t *cns = 0;
+ phaseg_t g;
+ char *fn_list = 0;
+ khash_t(set64) *set = 0;
+ errmod_t *em;
+ uint16_t *bases;
+
+ memset(&g, 0, sizeof(phaseg_t));
+ g.flag = FLAG_FIX_CHIMERA;
+ g.min_varLOD = 37; g.k = 13; g.min_baseQ = 13; g.max_depth = 256;
+ while ((c = getopt(argc, argv, "Q:eFq:k:b:l:D:A:")) >= 0) {
+ switch (c) {
+ case 'D': g.max_depth = atoi(optarg); break;
+ case 'q': g.min_varLOD = atoi(optarg); break;
+ case 'Q': g.min_baseQ = atoi(optarg); break;
+ case 'k': g.k = atoi(optarg); break;
+ case 'F': g.flag &= ~FLAG_FIX_CHIMERA; break;
+ case 'e': g.flag |= FLAG_LIST_EXCL; break;
+ case 'A': g.flag |= FLAG_DROP_AMBI; break;
+ case 'b': g.pre = strdup(optarg); break;
+ case 'l': fn_list = strdup(optarg); break;
+ }
+ }
+ if (argc == optind) {
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools phase [options] <in.bam>\n\n");
+ fprintf(pysamerr, "Options: -k INT block length [%d]\n", g.k);
+ fprintf(pysamerr, " -b STR prefix of BAMs to output [null]\n");
+ fprintf(pysamerr, " -q INT min het phred-LOD [%d]\n", g.min_varLOD);
+ fprintf(pysamerr, " -Q INT min base quality in het calling [%d]\n", g.min_baseQ);
+ fprintf(pysamerr, " -D INT max read depth [%d]\n", g.max_depth);
+// fprintf(pysamerr, " -l FILE list of sites to phase [null]\n");
+ fprintf(pysamerr, " -F do not attempt to fix chimeras\n");
+ fprintf(pysamerr, " -A drop reads with ambiguous phase\n");
+// fprintf(pysamerr, " -e do not discover SNPs (effective with -l)\n");
+ fprintf(pysamerr, "\n");
+ return 1;
+ }
+ g.fp = strcmp(argv[optind], "-")? bam_open(argv[optind], "r") : bam_dopen(fileno(stdin), "r");
+ h = bam_header_read(g.fp);
+ if (fn_list) { // read the list of sites to phase
+ bam_init_header_hash(h);
+ set = loadpos(fn_list, h);
+ free(fn_list);
+ } else g.flag &= ~FLAG_LIST_EXCL;
+ if (g.pre) { // open BAMs to write
+ char *s = malloc(strlen(g.pre) + 20);
+ strcpy(s, g.pre); strcat(s, ".0.bam"); g.out[0] = bam_open(s, "w");
+ strcpy(s, g.pre); strcat(s, ".1.bam"); g.out[1] = bam_open(s, "w");
+ strcpy(s, g.pre); strcat(s, ".chimera.bam"); g.out[2] = bam_open(s, "w");
+ for (c = 0; c <= 2; ++c) bam_header_write(g.out[c], h);
+ free(s);
+ }
+
+ iter = bam_plp_init(readaln, &g);
+ g.vpos_shift = 0;
+ seqs = kh_init(64);
+ em = errmod_init(1. - 0.83);
+ bases = calloc(g.max_depth, 2);
+ printf("CC\n");
+ printf("CC\tDescriptions:\nCC\n");
+ printf("CC\t CC comments\n");
+ printf("CC\t PS start of a phase set\n");
+ printf("CC\t FL filtered region\n");
+ printf("CC\t M[012] markers; 0 for singletons, 1 for phased and 2 for filtered\n");
+ printf("CC\t EV supporting reads; SAM format\n");
+ printf("CC\t // end of a phase set\nCC\n");
+ printf("CC\tFormats of PS, FL and M[012] lines (1-based coordinates):\nCC\n");
+ printf("CC\t PS chr phaseSetStart phaseSetEnd\n");
+ printf("CC\t FL chr filterStart filterEnd\n");
+ printf("CC\t M? chr PS pos allele0 allele1 hetIndex #supports0 #errors0 #supp1 #err1\n");
+ printf("CC\nCC\n");
+ fflush(stdout);
+ while ((plp = bam_plp_auto(iter, &tid, &pos, &n)) != 0) {
+ int i, k, c, tmp, dophase = 1, in_set = 0;
+ float q[16];
+ if (tid < 0) break;
+ if (tid != lasttid) { // change of chromosome
+ g.vpos_shift = 0;
+ if (lasttid >= 0) {
+ seqs = shrink_hash(seqs);
+ phase(&g, h->target_name[lasttid], vpos, cns, seqs);
+ update_vpos(0x7fffffff, seqs);
+ }
+ lasttid = tid;
+ vpos = 0;
+ }
+ if (set && kh_get(set64, set, (uint64_t)tid<<32 | pos) != kh_end(set)) in_set = 1;
+ if (n > g.max_depth) continue; // do not proceed if the depth is too high
+ // fill the bases array and check if there is a variant
+ for (i = k = 0; i < n; ++i) {
+ const bam_pileup1_t *p = plp + i;
+ uint8_t *seq;
+ int q, baseQ, b;
+ if (p->is_del || p->is_refskip) continue;
+ baseQ = bam1_qual(p->b)[p->qpos];
+ if (baseQ < g.min_baseQ) continue;
+ seq = bam1_seq(p->b);
+ b = bam_nt16_nt4_table[bam1_seqi(seq, p->qpos)];
+ if (b > 3) continue;
+ q = baseQ < p->b->core.qual? baseQ : p->b->core.qual;
+ if (q < 4) q = 4;
+ if (q > 63) q = 63;
+ bases[k++] = q<<5 | (int)bam1_strand(p->b)<<4 | b;
+ }
+ if (k == 0) continue;
+ errmod_cal(em, k, 4, bases, q); // compute genotype likelihood
+ c = gl2cns(q); // get the consensus
+ // tell if to proceed
+ if (set && (g.flag&FLAG_LIST_EXCL) && !in_set) continue; // not in the list
+ if (!in_set && (c&0xffff)>>2 < g.min_varLOD) continue; // not a variant
+ // add the variant
+ if (vpos == max_vpos) {
+ max_vpos = max_vpos? max_vpos<<1 : 128;
+ cns = realloc(cns, max_vpos * 8);
+ }
+ cns[vpos] = (uint64_t)pos<<32 | c;
+ for (i = 0; i < n; ++i) {
+ const bam_pileup1_t *p = plp + i;
+ uint64_t key;
+ khint_t k;
+ uint8_t *seq = bam1_seq(p->b);
+ frag_t *f;
+ if (p->is_del || p->is_refskip) continue;
+ if (p->b->core.qual == 0) continue;
+ // get the base code
+ c = nt16_nt4_table[(int)bam1_seqi(seq, p->qpos)];
+ if (c == (cns[vpos]&3)) c = 1;
+ else if (c == (cns[vpos]>>16&3)) c = 2;
+ else c = 0;
+ // write to seqs
+ key = X31_hash_string(bam1_qname(p->b));
+ k = kh_put(64, seqs, key, &tmp);
+ f = &kh_val(seqs, k);
+ if (tmp == 0) { // present in the hash table
+ if (vpos - f->vpos + 1 < MAX_VARS) {
+ f->vlen = vpos - f->vpos + 1;
+ f->seq[f->vlen-1] = c;
+ f->end = bam_calend(&p->b->core, bam1_cigar(p->b));
+ }
+ dophase = 0;
+ } else { // absent
+ memset(f->seq, 0, MAX_VARS);
+ f->beg = p->b->core.pos;
+ f->end = bam_calend(&p->b->core, bam1_cigar(p->b));
+ f->vpos = vpos, f->vlen = 1, f->seq[0] = c, f->single = f->phased = f->flip = f->ambig = 0;
+ }
+ }
+ if (dophase) {
+ seqs = shrink_hash(seqs);
+ phase(&g, h->target_name[tid], vpos, cns, seqs);
+ update_vpos(vpos, seqs);
+ cns[0] = cns[vpos];
+ vpos = 0;
+ }
+ ++vpos;
+ }
+ if (tid >= 0) phase(&g, h->target_name[tid], vpos, cns, seqs);
+ bam_header_destroy(h);
+ bam_plp_destroy(iter);
+ bam_close(g.fp);
+ kh_destroy(64, seqs);
+ kh_destroy(set64, set);
+ free(cns);
+ errmod_destroy(em);
+ free(bases);
+ if (g.pre) {
+ for (c = 0; c <= 2; ++c) bam_close(g.out[c]);
+ free(g.pre); free(g.b);
+ }
+ return 0;
+}
--- /dev/null
+#ifndef PYSAM_H
+#define PYSAM_H
+#include "stdio.h"
+extern FILE * pysamerr;
+#endif
+++ /dev/null
-/*
- * RAZF : Random Access compressed(Z) File
- * Version: 1.0
- * Release Date: 2008-10-27
- *
- * Copyright 2008, Jue Ruan <ruanjue@gmail.com>, Heng Li <lh3@sanger.ac.uk>
- *
- * All rights reserved.
- *
- * Redistribution and use in source and binary forms, with or without
- * modification, are permitted provided that the following conditions
- * are met:
- * 1. Redistributions of source code must retain the above copyright
- * notice, this list of conditions and the following disclaimer.
- * 2. Redistributions in binary form must reproduce the above copyright
- * notice, this list of conditions and the following disclaimer in the
- * documentation and/or other materials provided with the distribution.
- *
- * THIS SOFTWARE IS PROVIDED BY THE AUTHOR AND CONTRIBUTORS ``AS IS'' AND
- * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
- * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
- * ARE DISCLAIMED. IN NO EVENT SHALL THE AUTHOR OR CONTRIBUTORS BE LIABLE
- * FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
- * DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS
- * OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION)
- * HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT
- * LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY
- * OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF
- * SUCH DAMAGE.
- */
-
-#ifndef _NO_RAZF
-
-#include <fcntl.h>
-#include <stdio.h>
-#include <stdlib.h>
-#include <string.h>
-#include <unistd.h>
-#include "razf.h"
-
-
-#if ZLIB_VERNUM < 0x1221
-struct _gz_header_s {
- int text;
- uLong time;
- int xflags;
- int os;
- Bytef *extra;
- uInt extra_len;
- uInt extra_max;
- Bytef *name;
- uInt name_max;
- Bytef *comment;
- uInt comm_max;
- int hcrc;
- int done;
-};
-#warning "zlib < 1.2.2.1; RAZF writing is disabled."
-#endif
-
-#define DEF_MEM_LEVEL 8
-
-static inline uint32_t byte_swap_4(uint32_t v){
- v = ((v & 0x0000FFFFU) << 16) | (v >> 16);
- return ((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8);
-}
-
-static inline uint64_t byte_swap_8(uint64_t v){
- v = ((v & 0x00000000FFFFFFFFLLU) << 32) | (v >> 32);
- v = ((v & 0x0000FFFF0000FFFFLLU) << 16) | ((v & 0xFFFF0000FFFF0000LLU) >> 16);
- return ((v & 0x00FF00FF00FF00FFLLU) << 8) | ((v & 0xFF00FF00FF00FF00LLU) >> 8);
-}
-
-static inline int is_big_endian(){
- int x = 0x01;
- char *c = (char*)&x;
- return (c[0] != 0x01);
-}
-
-#ifndef _RZ_READONLY
-static void add_zindex(RAZF *rz, int64_t in, int64_t out){
- if(rz->index->size == rz->index->cap){
- rz->index->cap = rz->index->cap * 1.5 + 2;
- rz->index->cell_offsets = realloc(rz->index->cell_offsets, sizeof(int) * rz->index->cap);
- rz->index->bin_offsets = realloc(rz->index->bin_offsets, sizeof(int64_t) * (rz->index->cap/RZ_BIN_SIZE + 1));
- }
- if(rz->index->size % RZ_BIN_SIZE == 0) rz->index->bin_offsets[rz->index->size / RZ_BIN_SIZE] = out;
- rz->index->cell_offsets[rz->index->size] = out - rz->index->bin_offsets[rz->index->size / RZ_BIN_SIZE];
- rz->index->size ++;
-}
-
-static void save_zindex(RAZF *rz, int fd){
- int32_t i, v32;
- int is_be;
- is_be = is_big_endian();
- if(is_be) write(fd, &rz->index->size, sizeof(int));
- else {
- v32 = byte_swap_4((uint32_t)rz->index->size);
- write(fd, &v32, sizeof(uint32_t));
- }
- v32 = rz->index->size / RZ_BIN_SIZE + 1;
- if(!is_be){
- for(i=0;i<v32;i++) rz->index->bin_offsets[i] = byte_swap_8((uint64_t)rz->index->bin_offsets[i]);
- for(i=0;i<rz->index->size;i++) rz->index->cell_offsets[i] = byte_swap_4((uint32_t)rz->index->cell_offsets[i]);
- }
- write(fd, rz->index->bin_offsets, sizeof(int64_t) * v32);
- write(fd, rz->index->cell_offsets, sizeof(int32_t) * rz->index->size);
-}
-#endif
-
-#ifdef _USE_KNETFILE
-static void load_zindex(RAZF *rz, knetFile *fp){
-#else
-static void load_zindex(RAZF *rz, int fd){
-#endif
- int32_t i, v32;
- int is_be;
- if(!rz->load_index) return;
- if(rz->index == NULL) rz->index = malloc(sizeof(ZBlockIndex));
- is_be = is_big_endian();
-#ifdef _USE_KNETFILE
- knet_read(fp, &rz->index->size, sizeof(int));
-#else
- read(fd, &rz->index->size, sizeof(int));
-#endif
- if(!is_be) rz->index->size = byte_swap_4((uint32_t)rz->index->size);
- rz->index->cap = rz->index->size;
- v32 = rz->index->size / RZ_BIN_SIZE + 1;
- rz->index->bin_offsets = malloc(sizeof(int64_t) * v32);
-#ifdef _USE_KNETFILE
- knet_read(fp, rz->index->bin_offsets, sizeof(int64_t) * v32);
-#else
- read(fd, rz->index->bin_offsets, sizeof(int64_t) * v32);
-#endif
- rz->index->cell_offsets = malloc(sizeof(int) * rz->index->size);
-#ifdef _USE_KNETFILE
- knet_read(fp, rz->index->cell_offsets, sizeof(int) * rz->index->size);
-#else
- read(fd, rz->index->cell_offsets, sizeof(int) * rz->index->size);
-#endif
- if(!is_be){
- for(i=0;i<v32;i++) rz->index->bin_offsets[i] = byte_swap_8((uint64_t)rz->index->bin_offsets[i]);
- for(i=0;i<rz->index->size;i++) rz->index->cell_offsets[i] = byte_swap_4((uint32_t)rz->index->cell_offsets[i]);
- }
-}
-
-#ifdef _RZ_READONLY
-static RAZF* razf_open_w(int fd)
-{
- fprintf(stderr, "[razf_open_w] Writing is not available with zlib ver < 1.2.2.1\n");
- return 0;
-}
-#else
-static RAZF* razf_open_w(int fd){
- RAZF *rz;
-#ifdef _WIN32
- setmode(fd, O_BINARY);
-#endif
- rz = calloc(1, sizeof(RAZF));
- rz->mode = 'w';
-#ifdef _USE_KNETFILE
- rz->x.fpw = fd;
-#else
- rz->filedes = fd;
-#endif
- rz->stream = calloc(sizeof(z_stream), 1);
- rz->inbuf = malloc(RZ_BUFFER_SIZE);
- rz->outbuf = malloc(RZ_BUFFER_SIZE);
- rz->index = calloc(sizeof(ZBlockIndex), 1);
- deflateInit2(rz->stream, RZ_COMPRESS_LEVEL, Z_DEFLATED, WINDOW_BITS + 16, DEF_MEM_LEVEL, Z_DEFAULT_STRATEGY);
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- rz->header = calloc(sizeof(gz_header), 1);
- rz->header->os = 0x03; //Unix
- rz->header->text = 0;
- rz->header->time = 0;
- rz->header->extra = malloc(7);
- strncpy((char*)rz->header->extra, "RAZF", 4);
- rz->header->extra[4] = 1; // obsolete field
- // block size = RZ_BLOCK_SIZE, Big-Endian
- rz->header->extra[5] = RZ_BLOCK_SIZE >> 8;
- rz->header->extra[6] = RZ_BLOCK_SIZE & 0xFF;
- rz->header->extra_len = 7;
- rz->header->name = rz->header->comment = 0;
- rz->header->hcrc = 0;
- deflateSetHeader(rz->stream, rz->header);
- rz->block_pos = rz->block_off = 0;
- return rz;
-}
-
-static void _razf_write(RAZF* rz, const void *data, int size){
- int tout;
- rz->stream->avail_in = size;
- rz->stream->next_in = (void*)data;
- while(1){
- tout = rz->stream->avail_out;
- deflate(rz->stream, Z_NO_FLUSH);
- rz->out += tout - rz->stream->avail_out;
- if(rz->stream->avail_out) break;
-#ifdef _USE_KNETFILE
- write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#else
- write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#endif
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- if(rz->stream->avail_in == 0) break;
- };
- rz->in += size - rz->stream->avail_in;
- rz->block_off += size - rz->stream->avail_in;
-}
-
-static void razf_flush(RAZF *rz){
- uint32_t tout;
- if(rz->buf_len){
- _razf_write(rz, rz->inbuf, rz->buf_len);
- rz->buf_off = rz->buf_len = 0;
- }
- if(rz->stream->avail_out){
-#ifdef _USE_KNETFILE
- write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#else
- write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#endif
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- }
- while(1){
- tout = rz->stream->avail_out;
- deflate(rz->stream, Z_FULL_FLUSH);
- rz->out += tout - rz->stream->avail_out;
- if(rz->stream->avail_out == 0){
-#ifdef _USE_KNETFILE
- write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#else
- write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#endif
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- } else break;
- }
- rz->block_pos = rz->out;
- rz->block_off = 0;
-}
-
-static void razf_end_flush(RAZF *rz){
- uint32_t tout;
- if(rz->buf_len){
- _razf_write(rz, rz->inbuf, rz->buf_len);
- rz->buf_off = rz->buf_len = 0;
- }
- while(1){
- tout = rz->stream->avail_out;
- deflate(rz->stream, Z_FINISH);
- rz->out += tout - rz->stream->avail_out;
- if(rz->stream->avail_out < RZ_BUFFER_SIZE){
-#ifdef _USE_KNETFILE
- write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#else
- write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
-#endif
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- } else break;
- }
-}
-
-static void _razf_buffered_write(RAZF *rz, const void *data, int size){
- int i, n;
- while(1){
- if(rz->buf_len == RZ_BUFFER_SIZE){
- _razf_write(rz, rz->inbuf, rz->buf_len);
- rz->buf_len = 0;
- }
- if(size + rz->buf_len < RZ_BUFFER_SIZE){
- for(i=0;i<size;i++) ((char*)rz->inbuf + rz->buf_len)[i] = ((char*)data)[i];
- rz->buf_len += size;
- return;
- } else {
- n = RZ_BUFFER_SIZE - rz->buf_len;
- for(i=0;i<n;i++) ((char*)rz->inbuf + rz->buf_len)[i] = ((char*)data)[i];
- size -= n;
- data += n;
- rz->buf_len += n;
- }
- }
-}
-
-int razf_write(RAZF* rz, const void *data, int size){
- int ori_size, n;
- int64_t next_block;
- ori_size = size;
- next_block = ((rz->in / RZ_BLOCK_SIZE) + 1) * RZ_BLOCK_SIZE;
- while(rz->in + rz->buf_len + size >= next_block){
- n = next_block - rz->in - rz->buf_len;
- _razf_buffered_write(rz, data, n);
- data += n;
- size -= n;
- razf_flush(rz);
- add_zindex(rz, rz->in, rz->out);
- next_block = ((rz->in / RZ_BLOCK_SIZE) + 1) * RZ_BLOCK_SIZE;
- }
- _razf_buffered_write(rz, data, size);
- return ori_size;
-}
-#endif
-
-/* gzip flag byte */
-#define ASCII_FLAG 0x01 /* bit 0 set: file probably ascii text */
-#define HEAD_CRC 0x02 /* bit 1 set: header CRC present */
-#define EXTRA_FIELD 0x04 /* bit 2 set: extra field present */
-#define ORIG_NAME 0x08 /* bit 3 set: original file name present */
-#define COMMENT 0x10 /* bit 4 set: file comment present */
-#define RESERVED 0xE0 /* bits 5..7: reserved */
-
-static int _read_gz_header(unsigned char *data, int size, int *extra_off, int *extra_len){
- int method, flags, n, len;
- if(size < 2) return 0;
- if(data[0] != 0x1f || data[1] != 0x8b) return 0;
- if(size < 4) return 0;
- method = data[2];
- flags = data[3];
- if(method != Z_DEFLATED || (flags & RESERVED)) return 0;
- n = 4 + 6; // Skip 6 bytes
- *extra_off = n + 2;
- *extra_len = 0;
- if(flags & EXTRA_FIELD){
- if(size < n + 2) return 0;
- len = ((int)data[n + 1] << 8) | data[n];
- n += 2;
- *extra_off = n;
- while(len){
- if(n >= size) return 0;
- n ++;
- len --;
- }
- *extra_len = n - (*extra_off);
- }
- if(flags & ORIG_NAME) while(n < size && data[n++]);
- if(flags & COMMENT) while(n < size && data[n++]);
- if(flags & HEAD_CRC){
- if(n + 2 > size) return 0;
- n += 2;
- }
- return n;
-}
-
-#ifdef _USE_KNETFILE
-static RAZF* razf_open_r(knetFile *fp, int _load_index){
-#else
-static RAZF* razf_open_r(int fd, int _load_index){
-#endif
- RAZF *rz;
- int ext_off, ext_len;
- int n, is_be, ret;
- int64_t end;
- unsigned char c[] = "RAZF";
- rz = calloc(1, sizeof(RAZF));
- rz->mode = 'r';
-#ifdef _USE_KNETFILE
- rz->x.fpr = fp;
-#else
-#ifdef _WIN32
- setmode(fd, O_BINARY);
-#endif
- rz->filedes = fd;
-#endif
- rz->stream = calloc(sizeof(z_stream), 1);
- rz->inbuf = malloc(RZ_BUFFER_SIZE);
- rz->outbuf = malloc(RZ_BUFFER_SIZE);
- rz->end = rz->src_end = 0x7FFFFFFFFFFFFFFFLL;
-#ifdef _USE_KNETFILE
- n = knet_read(rz->x.fpr, rz->inbuf, RZ_BUFFER_SIZE);
-#else
- n = read(rz->filedes, rz->inbuf, RZ_BUFFER_SIZE);
-#endif
- ret = _read_gz_header(rz->inbuf, n, &ext_off, &ext_len);
- if(ret == 0){
- PLAIN_FILE:
- rz->in = n;
- rz->file_type = FILE_TYPE_PLAIN;
- memcpy(rz->outbuf, rz->inbuf, n);
- rz->buf_len = n;
- free(rz->stream);
- rz->stream = NULL;
- return rz;
- }
- rz->header_size = ret;
- ret = inflateInit2(rz->stream, -WINDOW_BITS);
- if(ret != Z_OK){ inflateEnd(rz->stream); goto PLAIN_FILE;}
- rz->stream->avail_in = n - rz->header_size;
- rz->stream->next_in = rz->inbuf + rz->header_size;
- rz->stream->avail_out = RZ_BUFFER_SIZE;
- rz->stream->next_out = rz->outbuf;
- rz->file_type = FILE_TYPE_GZ;
- rz->in = rz->header_size;
- rz->block_pos = rz->header_size;
- rz->next_block_pos = rz->header_size;
- rz->block_off = 0;
- if(ext_len < 7 || memcmp(rz->inbuf + ext_off, c, 4) != 0) return rz;
- if(((((unsigned char*)rz->inbuf)[ext_off + 5] << 8) | ((unsigned char*)rz->inbuf)[ext_off + 6]) != RZ_BLOCK_SIZE){
- fprintf(stderr, " -- WARNING: RZ_BLOCK_SIZE is not %d, treat source as gz file. in %s -- %s:%d --\n", RZ_BLOCK_SIZE, __FUNCTION__, __FILE__, __LINE__);
- return rz;
- }
- rz->load_index = _load_index;
- rz->file_type = FILE_TYPE_RZ;
-#ifdef _USE_KNETFILE
- if(knet_seek(fp, -16, SEEK_END) == -1){
-#else
- if(lseek(fd, -16, SEEK_END) == -1){
-#endif
- UNSEEKABLE:
- rz->seekable = 0;
- rz->index = NULL;
- rz->src_end = rz->end = 0x7FFFFFFFFFFFFFFFLL;
- } else {
- is_be = is_big_endian();
- rz->seekable = 1;
-#ifdef _USE_KNETFILE
- knet_read(fp, &end, sizeof(int64_t));
-#else
- read(fd, &end, sizeof(int64_t));
-#endif
- if(!is_be) rz->src_end = (int64_t)byte_swap_8((uint64_t)end);
- else rz->src_end = end;
-
-#ifdef _USE_KNETFILE
- knet_read(fp, &end, sizeof(int64_t));
-#else
- read(fd, &end, sizeof(int64_t));
-#endif
- if(!is_be) rz->end = (int64_t)byte_swap_8((uint64_t)end);
- else rz->end = end;
- if(n > rz->end){
- rz->stream->avail_in -= n - rz->end;
- n = rz->end;
- }
- if(rz->end > rz->src_end){
-#ifdef _USE_KNETFILE
- knet_seek(fp, rz->in, SEEK_SET);
-#else
- lseek(fd, rz->in, SEEK_SET);
-#endif
- goto UNSEEKABLE;
- }
-#ifdef _USE_KNETFILE
- knet_seek(fp, rz->end, SEEK_SET);
- if(knet_tell(fp) != rz->end){
- knet_seek(fp, rz->in, SEEK_SET);
-#else
- if(lseek(fd, rz->end, SEEK_SET) != rz->end){
- lseek(fd, rz->in, SEEK_SET);
-#endif
- goto UNSEEKABLE;
- }
-#ifdef _USE_KNETFILE
- load_zindex(rz, fp);
- knet_seek(fp, n, SEEK_SET);
-#else
- load_zindex(rz, fd);
- lseek(fd, n, SEEK_SET);
-#endif
- }
- return rz;
-}
-
-#ifdef _USE_KNETFILE
-RAZF* razf_dopen(int fd, const char *mode){
- if (strstr(mode, "r")) fprintf(stderr,"[razf_dopen] implement me\n");
- else if(strstr(mode, "w")) return razf_open_w(fd);
- return NULL;
-}
-
-RAZF* razf_dopen2(int fd, const char *mode)
-{
- fprintf(stderr,"[razf_dopen2] implement me\n");
- return NULL;
-}
-#else
-RAZF* razf_dopen(int fd, const char *mode){
- if(strstr(mode, "r")) return razf_open_r(fd, 1);
- else if(strstr(mode, "w")) return razf_open_w(fd);
- else return NULL;
-}
-
-RAZF* razf_dopen2(int fd, const char *mode)
-{
- if(strstr(mode, "r")) return razf_open_r(fd, 0);
- else if(strstr(mode, "w")) return razf_open_w(fd);
- else return NULL;
-}
-#endif
-
-static inline RAZF* _razf_open(const char *filename, const char *mode, int _load_index){
- int fd;
- RAZF *rz;
- if(strstr(mode, "r")){
-#ifdef _USE_KNETFILE
- knetFile *fd = knet_open(filename, "r");
- if (fd == 0) {
- fprintf(stderr, "[_razf_open] fail to open %s\n", filename);
- return NULL;
- }
-#else
-#ifdef _WIN32
- fd = open(filename, O_RDONLY | O_BINARY);
-#else
- fd = open(filename, O_RDONLY);
-#endif
-#endif
- if(fd < 0) return NULL;
- rz = razf_open_r(fd, _load_index);
- } else if(strstr(mode, "w")){
-#ifdef _WIN32
- fd = open(filename, O_WRONLY | O_CREAT | O_TRUNC | O_BINARY, 0666);
-#else
- fd = open(filename, O_WRONLY | O_CREAT | O_TRUNC, 0666);
-#endif
- if(fd < 0) return NULL;
- rz = razf_open_w(fd);
- } else return NULL;
- return rz;
-}
-
-RAZF* razf_open(const char *filename, const char *mode){
- return _razf_open(filename, mode, 1);
-}
-
-RAZF* razf_open2(const char *filename, const char *mode){
- return _razf_open(filename, mode, 0);
-}
-
-int razf_get_data_size(RAZF *rz, int64_t *u_size, int64_t *c_size){
- int64_t n;
- if(rz->mode != 'r' && rz->mode != 'R') return 0;
- switch(rz->file_type){
- case FILE_TYPE_PLAIN:
- if(rz->end == 0x7fffffffffffffffLL){
-#ifdef _USE_KNETFILE
- if(knet_seek(rz->x.fpr, 0, SEEK_CUR) == -1) return 0;
- n = knet_tell(rz->x.fpr);
- knet_seek(rz->x.fpr, 0, SEEK_END);
- rz->end = knet_tell(rz->x.fpr);
- knet_seek(rz->x.fpr, n, SEEK_SET);
-#else
- if((n = lseek(rz->filedes, 0, SEEK_CUR)) == -1) return 0;
- rz->end = lseek(rz->filedes, 0, SEEK_END);
- lseek(rz->filedes, n, SEEK_SET);
-#endif
- }
- *u_size = *c_size = rz->end;
- return 1;
- case FILE_TYPE_GZ:
- return 0;
- case FILE_TYPE_RZ:
- if(rz->src_end == rz->end) return 0;
- *u_size = rz->src_end;
- *c_size = rz->end;
- return 1;
- default:
- return 0;
- }
-}
-
-static int _razf_read(RAZF* rz, void *data, int size){
- int ret, tin;
- if(rz->z_eof || rz->z_err) return 0;
- if (rz->file_type == FILE_TYPE_PLAIN) {
-#ifdef _USE_KNETFILE
- ret = knet_read(rz->x.fpr, data, size);
-#else
- ret = read(rz->filedes, data, size);
-#endif
- if (ret == 0) rz->z_eof = 1;
- return ret;
- }
- rz->stream->avail_out = size;
- rz->stream->next_out = data;
- while(rz->stream->avail_out){
- if(rz->stream->avail_in == 0){
- if(rz->in >= rz->end){ rz->z_eof = 1; break; }
- if(rz->end - rz->in < RZ_BUFFER_SIZE){
-#ifdef _USE_KNETFILE
- rz->stream->avail_in = knet_read(rz->x.fpr, rz->inbuf, rz->end -rz->in);
-#else
- rz->stream->avail_in = read(rz->filedes, rz->inbuf, rz->end -rz->in);
-#endif
- } else {
-#ifdef _USE_KNETFILE
- rz->stream->avail_in = knet_read(rz->x.fpr, rz->inbuf, RZ_BUFFER_SIZE);
-#else
- rz->stream->avail_in = read(rz->filedes, rz->inbuf, RZ_BUFFER_SIZE);
-#endif
- }
- if(rz->stream->avail_in == 0){
- rz->z_eof = 1;
- break;
- }
- rz->stream->next_in = rz->inbuf;
- }
- tin = rz->stream->avail_in;
- ret = inflate(rz->stream, Z_BLOCK);
- rz->in += tin - rz->stream->avail_in;
- if(ret == Z_NEED_DICT || ret == Z_MEM_ERROR || ret == Z_DATA_ERROR){
- fprintf(stderr, "[_razf_read] inflate error: %d %s (at %s:%d)\n", ret, rz->stream->msg ? rz->stream->msg : "", __FILE__, __LINE__);
- rz->z_err = 1;
- break;
- }
- if(ret == Z_STREAM_END){
- rz->z_eof = 1;
- break;
- }
- if ((rz->stream->data_type&128) && !(rz->stream->data_type&64)){
- rz->buf_flush = 1;
- rz->next_block_pos = rz->in;
- break;
- }
- }
- return size - rz->stream->avail_out;
-}
-
-int razf_read(RAZF *rz, void *data, int size){
- int ori_size, i;
- ori_size = size;
- while(size > 0){
- if(rz->buf_len){
- if(size < rz->buf_len){
- for(i=0;i<size;i++) ((char*)data)[i] = ((char*)rz->outbuf + rz->buf_off)[i];
- rz->buf_off += size;
- rz->buf_len -= size;
- data += size;
- rz->block_off += size;
- size = 0;
- break;
- } else {
- for(i=0;i<rz->buf_len;i++) ((char*)data)[i] = ((char*)rz->outbuf + rz->buf_off)[i];
- data += rz->buf_len;
- size -= rz->buf_len;
- rz->block_off += rz->buf_len;
- rz->buf_off = 0;
- rz->buf_len = 0;
- if(rz->buf_flush){
- rz->block_pos = rz->next_block_pos;
- rz->block_off = 0;
- rz->buf_flush = 0;
- }
- }
- } else if(rz->buf_flush){
- rz->block_pos = rz->next_block_pos;
- rz->block_off = 0;
- rz->buf_flush = 0;
- }
- if(rz->buf_flush) continue;
- rz->buf_len = _razf_read(rz, rz->outbuf, RZ_BUFFER_SIZE);
- if(rz->z_eof && rz->buf_len == 0) break;
- }
- rz->out += ori_size - size;
- return ori_size - size;
-}
-
-int razf_skip(RAZF* rz, int size){
- int ori_size;
- ori_size = size;
- while(size > 0){
- if(rz->buf_len){
- if(size < rz->buf_len){
- rz->buf_off += size;
- rz->buf_len -= size;
- rz->block_off += size;
- size = 0;
- break;
- } else {
- size -= rz->buf_len;
- rz->buf_off = 0;
- rz->buf_len = 0;
- rz->block_off += rz->buf_len;
- if(rz->buf_flush){
- rz->block_pos = rz->next_block_pos;
- rz->block_off = 0;
- rz->buf_flush = 0;
- }
- }
- } else if(rz->buf_flush){
- rz->block_pos = rz->next_block_pos;
- rz->block_off = 0;
- rz->buf_flush = 0;
- }
- if(rz->buf_flush) continue;
- rz->buf_len = _razf_read(rz, rz->outbuf, RZ_BUFFER_SIZE);
- if(rz->z_eof || rz->z_err) break;
- }
- rz->out += ori_size - size;
- return ori_size - size;
-}
-
-static void _razf_reset_read(RAZF *rz, int64_t in, int64_t out){
-#ifdef _USE_KNETFILE
- knet_seek(rz->x.fpr, in, SEEK_SET);
-#else
- lseek(rz->filedes, in, SEEK_SET);
-#endif
- rz->in = in;
- rz->out = out;
- rz->block_pos = in;
- rz->next_block_pos = in;
- rz->block_off = 0;
- rz->buf_flush = 0;
- rz->z_eof = rz->z_err = 0;
- inflateReset(rz->stream);
- rz->stream->avail_in = 0;
- rz->buf_off = rz->buf_len = 0;
-}
-
-int64_t razf_jump(RAZF *rz, int64_t block_start, int block_offset){
- int64_t pos;
- rz->z_eof = 0;
- if(rz->file_type == FILE_TYPE_PLAIN){
- rz->buf_off = rz->buf_len = 0;
- pos = block_start + block_offset;
-#ifdef _USE_KNETFILE
- knet_seek(rz->x.fpr, pos, SEEK_SET);
- pos = knet_tell(rz->x.fpr);
-#else
- pos = lseek(rz->filedes, pos, SEEK_SET);
-#endif
- rz->out = rz->in = pos;
- return pos;
- }
- if(block_start == rz->block_pos && block_offset >= rz->block_off) {
- block_offset -= rz->block_off;
- goto SKIP; // Needn't reset inflate
- }
- if(block_start == 0) block_start = rz->header_size; // Automaticly revist wrong block_start
- _razf_reset_read(rz, block_start, 0);
- SKIP:
- if(block_offset) razf_skip(rz, block_offset);
- return rz->block_off;
-}
-
-int64_t razf_seek(RAZF* rz, int64_t pos, int where){
- int64_t idx;
- int64_t seek_pos, new_out;
- rz->z_eof = 0;
- if (where == SEEK_CUR) pos += rz->out;
- else if (where == SEEK_END) pos += rz->src_end;
- if(rz->file_type == FILE_TYPE_PLAIN){
-#ifdef _USE_KNETFILE
- knet_seek(rz->x.fpr, pos, SEEK_SET);
- seek_pos = knet_tell(rz->x.fpr);
-#else
- seek_pos = lseek(rz->filedes, pos, SEEK_SET);
-#endif
- rz->buf_off = rz->buf_len = 0;
- rz->out = rz->in = seek_pos;
- return seek_pos;
- } else if(rz->file_type == FILE_TYPE_GZ){
- if(pos >= rz->out) goto SKIP;
- return rz->out;
- }
- if(pos == rz->out) return pos;
- if(pos > rz->src_end) return rz->out;
- if(!rz->seekable || !rz->load_index){
- if(pos >= rz->out) goto SKIP;
- }
- idx = pos / RZ_BLOCK_SIZE - 1;
- seek_pos = (idx < 0)? rz->header_size:(rz->index->cell_offsets[idx] + rz->index->bin_offsets[idx / RZ_BIN_SIZE]);
- new_out = (idx + 1) * RZ_BLOCK_SIZE;
- if(pos > rz->out && new_out <= rz->out) goto SKIP;
- _razf_reset_read(rz, seek_pos, new_out);
- SKIP:
- razf_skip(rz, (int)(pos - rz->out));
- return rz->out;
-}
-
-uint64_t razf_tell2(RAZF *rz)
-{
- /*
- if (rz->load_index) {
- int64_t idx, seek_pos;
- idx = rz->out / RZ_BLOCK_SIZE - 1;
- seek_pos = (idx < 0)? rz->header_size:(rz->index->cell_offsets[idx] + rz->index->bin_offsets[idx / RZ_BIN_SIZE]);
- if (seek_pos != rz->block_pos || rz->out%RZ_BLOCK_SIZE != rz->block_off)
- fprintf(stderr, "[razf_tell2] inconsistent block offset: (%lld, %lld) != (%lld, %lld)\n",
- (long long)seek_pos, (long long)rz->out%RZ_BLOCK_SIZE, (long long)rz->block_pos, (long long) rz->block_off);
- }
- */
- return (uint64_t)rz->block_pos<<16 | (rz->block_off&0xffff);
-}
-
-int64_t razf_seek2(RAZF *rz, uint64_t voffset, int where)
-{
- if (where != SEEK_SET) return -1;
- return razf_jump(rz, voffset>>16, voffset&0xffff);
-}
-
-void razf_close(RAZF *rz){
- if(rz->mode == 'w'){
-#ifndef _RZ_READONLY
- razf_end_flush(rz);
- deflateEnd(rz->stream);
-#ifdef _USE_KNETFILE
- save_zindex(rz, rz->x.fpw);
- if(is_big_endian()){
- write(rz->x.fpw, &rz->in, sizeof(int64_t));
- write(rz->x.fpw, &rz->out, sizeof(int64_t));
- } else {
- uint64_t v64 = byte_swap_8((uint64_t)rz->in);
- write(rz->x.fpw, &v64, sizeof(int64_t));
- v64 = byte_swap_8((uint64_t)rz->out);
- write(rz->x.fpw, &v64, sizeof(int64_t));
- }
-#else
- save_zindex(rz, rz->filedes);
- if(is_big_endian()){
- write(rz->filedes, &rz->in, sizeof(int64_t));
- write(rz->filedes, &rz->out, sizeof(int64_t));
- } else {
- uint64_t v64 = byte_swap_8((uint64_t)rz->in);
- write(rz->filedes, &v64, sizeof(int64_t));
- v64 = byte_swap_8((uint64_t)rz->out);
- write(rz->filedes, &v64, sizeof(int64_t));
- }
-#endif
-#endif
- } else if(rz->mode == 'r'){
- if(rz->stream) inflateEnd(rz->stream);
- }
- if(rz->inbuf) free(rz->inbuf);
- if(rz->outbuf) free(rz->outbuf);
- if(rz->header){
- free(rz->header->extra);
- free(rz->header->name);
- free(rz->header->comment);
- free(rz->header);
- }
- if(rz->index){
- free(rz->index->bin_offsets);
- free(rz->index->cell_offsets);
- free(rz->index);
- }
- free(rz->stream);
-#ifdef _USE_KNETFILE
- if (rz->mode == 'r')
- knet_close(rz->x.fpr);
- if (rz->mode == 'w')
- close(rz->x.fpw);
-#else
- close(rz->filedes);
-#endif
- free(rz);
-}
-
-#endif
--- /dev/null
+#include "pysam.h"
+
+/*
+ * RAZF : Random Access compressed(Z) File
+ * Version: 1.0
+ * Release Date: 2008-10-27
+ *
+ * Copyright 2008, Jue Ruan <ruanjue@gmail.com>, Heng Li <lh3@sanger.ac.uk>
+ *
+ * All rights reserved.
+ *
+ * Redistribution and use in source and binary forms, with or without
+ * modification, are permitted provided that the following conditions
+ * are met:
+ * 1. Redistributions of source code must retain the above copyright
+ * notice, this list of conditions and the following disclaimer.
+ * 2. Redistributions in binary form must reproduce the above copyright
+ * notice, this list of conditions and the following disclaimer in the
+ * documentation and/or other materials provided with the distribution.
+ *
+ * THIS SOFTWARE IS PROVIDED BY THE AUTHOR AND CONTRIBUTORS ``AS IS'' AND
+ * ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+ * IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
+ * ARE DISCLAIMED. IN NO EVENT SHALL THE AUTHOR OR CONTRIBUTORS BE LIABLE
+ * FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL
+ * DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS
+ * OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION)
+ * HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT
+ * LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY
+ * OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF
+ * SUCH DAMAGE.
+ */
+
+#ifndef _NO_RAZF
+
+#include <fcntl.h>
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+#include <unistd.h>
+#include "razf.h"
+
+
+#if ZLIB_VERNUM < 0x1221
+struct _gz_header_s {
+ int text;
+ uLong time;
+ int xflags;
+ int os;
+ Bytef *extra;
+ uInt extra_len;
+ uInt extra_max;
+ Bytef *name;
+ uInt name_max;
+ Bytef *comment;
+ uInt comm_max;
+ int hcrc;
+ int done;
+};
+#warning "zlib < 1.2.2.1; RAZF writing is disabled."
+#endif
+
+#define DEF_MEM_LEVEL 8
+
+static inline uint32_t byte_swap_4(uint32_t v){
+ v = ((v & 0x0000FFFFU) << 16) | (v >> 16);
+ return ((v & 0x00FF00FFU) << 8) | ((v & 0xFF00FF00U) >> 8);
+}
+
+static inline uint64_t byte_swap_8(uint64_t v){
+ v = ((v & 0x00000000FFFFFFFFLLU) << 32) | (v >> 32);
+ v = ((v & 0x0000FFFF0000FFFFLLU) << 16) | ((v & 0xFFFF0000FFFF0000LLU) >> 16);
+ return ((v & 0x00FF00FF00FF00FFLLU) << 8) | ((v & 0xFF00FF00FF00FF00LLU) >> 8);
+}
+
+static inline int is_big_endian(){
+ int x = 0x01;
+ char *c = (char*)&x;
+ return (c[0] != 0x01);
+}
+
+#ifndef _RZ_READONLY
+static void add_zindex(RAZF *rz, int64_t in, int64_t out){
+ if(rz->index->size == rz->index->cap){
+ rz->index->cap = rz->index->cap * 1.5 + 2;
+ rz->index->cell_offsets = realloc(rz->index->cell_offsets, sizeof(int) * rz->index->cap);
+ rz->index->bin_offsets = realloc(rz->index->bin_offsets, sizeof(int64_t) * (rz->index->cap/RZ_BIN_SIZE + 1));
+ }
+ if(rz->index->size % RZ_BIN_SIZE == 0) rz->index->bin_offsets[rz->index->size / RZ_BIN_SIZE] = out;
+ rz->index->cell_offsets[rz->index->size] = out - rz->index->bin_offsets[rz->index->size / RZ_BIN_SIZE];
+ rz->index->size ++;
+}
+
+static void save_zindex(RAZF *rz, int fd){
+ int32_t i, v32;
+ int is_be;
+ is_be = is_big_endian();
+ if(is_be) write(fd, &rz->index->size, sizeof(int));
+ else {
+ v32 = byte_swap_4((uint32_t)rz->index->size);
+ write(fd, &v32, sizeof(uint32_t));
+ }
+ v32 = rz->index->size / RZ_BIN_SIZE + 1;
+ if(!is_be){
+ for(i=0;i<v32;i++) rz->index->bin_offsets[i] = byte_swap_8((uint64_t)rz->index->bin_offsets[i]);
+ for(i=0;i<rz->index->size;i++) rz->index->cell_offsets[i] = byte_swap_4((uint32_t)rz->index->cell_offsets[i]);
+ }
+ write(fd, rz->index->bin_offsets, sizeof(int64_t) * v32);
+ write(fd, rz->index->cell_offsets, sizeof(int32_t) * rz->index->size);
+}
+#endif
+
+#ifdef _USE_KNETFILE
+static void load_zindex(RAZF *rz, knetFile *fp){
+#else
+static void load_zindex(RAZF *rz, int fd){
+#endif
+ int32_t i, v32;
+ int is_be;
+ if(!rz->load_index) return;
+ if(rz->index == NULL) rz->index = malloc(sizeof(ZBlockIndex));
+ is_be = is_big_endian();
+#ifdef _USE_KNETFILE
+ knet_read(fp, &rz->index->size, sizeof(int));
+#else
+ read(fd, &rz->index->size, sizeof(int));
+#endif
+ if(!is_be) rz->index->size = byte_swap_4((uint32_t)rz->index->size);
+ rz->index->cap = rz->index->size;
+ v32 = rz->index->size / RZ_BIN_SIZE + 1;
+ rz->index->bin_offsets = malloc(sizeof(int64_t) * v32);
+#ifdef _USE_KNETFILE
+ knet_read(fp, rz->index->bin_offsets, sizeof(int64_t) * v32);
+#else
+ read(fd, rz->index->bin_offsets, sizeof(int64_t) * v32);
+#endif
+ rz->index->cell_offsets = malloc(sizeof(int) * rz->index->size);
+#ifdef _USE_KNETFILE
+ knet_read(fp, rz->index->cell_offsets, sizeof(int) * rz->index->size);
+#else
+ read(fd, rz->index->cell_offsets, sizeof(int) * rz->index->size);
+#endif
+ if(!is_be){
+ for(i=0;i<v32;i++) rz->index->bin_offsets[i] = byte_swap_8((uint64_t)rz->index->bin_offsets[i]);
+ for(i=0;i<rz->index->size;i++) rz->index->cell_offsets[i] = byte_swap_4((uint32_t)rz->index->cell_offsets[i]);
+ }
+}
+
+#ifdef _RZ_READONLY
+static RAZF* razf_open_w(int fd)
+{
+ fprintf(pysamerr, "[razf_open_w] Writing is not available with zlib ver < 1.2.2.1\n");
+ return 0;
+}
+#else
+static RAZF* razf_open_w(int fd){
+ RAZF *rz;
+#ifdef _WIN32
+ setmode(fd, O_BINARY);
+#endif
+ rz = calloc(1, sizeof(RAZF));
+ rz->mode = 'w';
+#ifdef _USE_KNETFILE
+ rz->x.fpw = fd;
+#else
+ rz->filedes = fd;
+#endif
+ rz->stream = calloc(sizeof(z_stream), 1);
+ rz->inbuf = malloc(RZ_BUFFER_SIZE);
+ rz->outbuf = malloc(RZ_BUFFER_SIZE);
+ rz->index = calloc(sizeof(ZBlockIndex), 1);
+ deflateInit2(rz->stream, RZ_COMPRESS_LEVEL, Z_DEFLATED, WINDOW_BITS + 16, DEF_MEM_LEVEL, Z_DEFAULT_STRATEGY);
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ rz->header = calloc(sizeof(gz_header), 1);
+ rz->header->os = 0x03; //Unix
+ rz->header->text = 0;
+ rz->header->time = 0;
+ rz->header->extra = malloc(7);
+ strncpy((char*)rz->header->extra, "RAZF", 4);
+ rz->header->extra[4] = 1; // obsolete field
+ // block size = RZ_BLOCK_SIZE, Big-Endian
+ rz->header->extra[5] = RZ_BLOCK_SIZE >> 8;
+ rz->header->extra[6] = RZ_BLOCK_SIZE & 0xFF;
+ rz->header->extra_len = 7;
+ rz->header->name = rz->header->comment = 0;
+ rz->header->hcrc = 0;
+ deflateSetHeader(rz->stream, rz->header);
+ rz->block_pos = rz->block_off = 0;
+ return rz;
+}
+
+static void _razf_write(RAZF* rz, const void *data, int size){
+ int tout;
+ rz->stream->avail_in = size;
+ rz->stream->next_in = (void*)data;
+ while(1){
+ tout = rz->stream->avail_out;
+ deflate(rz->stream, Z_NO_FLUSH);
+ rz->out += tout - rz->stream->avail_out;
+ if(rz->stream->avail_out) break;
+#ifdef _USE_KNETFILE
+ write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#else
+ write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#endif
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ if(rz->stream->avail_in == 0) break;
+ };
+ rz->in += size - rz->stream->avail_in;
+ rz->block_off += size - rz->stream->avail_in;
+}
+
+static void razf_flush(RAZF *rz){
+ uint32_t tout;
+ if(rz->buf_len){
+ _razf_write(rz, rz->inbuf, rz->buf_len);
+ rz->buf_off = rz->buf_len = 0;
+ }
+ if(rz->stream->avail_out){
+#ifdef _USE_KNETFILE
+ write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#else
+ write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#endif
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ }
+ while(1){
+ tout = rz->stream->avail_out;
+ deflate(rz->stream, Z_FULL_FLUSH);
+ rz->out += tout - rz->stream->avail_out;
+ if(rz->stream->avail_out == 0){
+#ifdef _USE_KNETFILE
+ write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#else
+ write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#endif
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ } else break;
+ }
+ rz->block_pos = rz->out;
+ rz->block_off = 0;
+}
+
+static void razf_end_flush(RAZF *rz){
+ uint32_t tout;
+ if(rz->buf_len){
+ _razf_write(rz, rz->inbuf, rz->buf_len);
+ rz->buf_off = rz->buf_len = 0;
+ }
+ while(1){
+ tout = rz->stream->avail_out;
+ deflate(rz->stream, Z_FINISH);
+ rz->out += tout - rz->stream->avail_out;
+ if(rz->stream->avail_out < RZ_BUFFER_SIZE){
+#ifdef _USE_KNETFILE
+ write(rz->x.fpw, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#else
+ write(rz->filedes, rz->outbuf, RZ_BUFFER_SIZE - rz->stream->avail_out);
+#endif
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ } else break;
+ }
+}
+
+static void _razf_buffered_write(RAZF *rz, const void *data, int size){
+ int i, n;
+ while(1){
+ if(rz->buf_len == RZ_BUFFER_SIZE){
+ _razf_write(rz, rz->inbuf, rz->buf_len);
+ rz->buf_len = 0;
+ }
+ if(size + rz->buf_len < RZ_BUFFER_SIZE){
+ for(i=0;i<size;i++) ((char*)rz->inbuf + rz->buf_len)[i] = ((char*)data)[i];
+ rz->buf_len += size;
+ return;
+ } else {
+ n = RZ_BUFFER_SIZE - rz->buf_len;
+ for(i=0;i<n;i++) ((char*)rz->inbuf + rz->buf_len)[i] = ((char*)data)[i];
+ size -= n;
+ data += n;
+ rz->buf_len += n;
+ }
+ }
+}
+
+int razf_write(RAZF* rz, const void *data, int size){
+ int ori_size, n;
+ int64_t next_block;
+ ori_size = size;
+ next_block = ((rz->in / RZ_BLOCK_SIZE) + 1) * RZ_BLOCK_SIZE;
+ while(rz->in + rz->buf_len + size >= next_block){
+ n = next_block - rz->in - rz->buf_len;
+ _razf_buffered_write(rz, data, n);
+ data += n;
+ size -= n;
+ razf_flush(rz);
+ add_zindex(rz, rz->in, rz->out);
+ next_block = ((rz->in / RZ_BLOCK_SIZE) + 1) * RZ_BLOCK_SIZE;
+ }
+ _razf_buffered_write(rz, data, size);
+ return ori_size;
+}
+#endif
+
+/* gzip flag byte */
+#define ASCII_FLAG 0x01 /* bit 0 set: file probably ascii text */
+#define HEAD_CRC 0x02 /* bit 1 set: header CRC present */
+#define EXTRA_FIELD 0x04 /* bit 2 set: extra field present */
+#define ORIG_NAME 0x08 /* bit 3 set: original file name present */
+#define COMMENT 0x10 /* bit 4 set: file comment present */
+#define RESERVED 0xE0 /* bits 5..7: reserved */
+
+static int _read_gz_header(unsigned char *data, int size, int *extra_off, int *extra_len){
+ int method, flags, n, len;
+ if(size < 2) return 0;
+ if(data[0] != 0x1f || data[1] != 0x8b) return 0;
+ if(size < 4) return 0;
+ method = data[2];
+ flags = data[3];
+ if(method != Z_DEFLATED || (flags & RESERVED)) return 0;
+ n = 4 + 6; // Skip 6 bytes
+ *extra_off = n + 2;
+ *extra_len = 0;
+ if(flags & EXTRA_FIELD){
+ if(size < n + 2) return 0;
+ len = ((int)data[n + 1] << 8) | data[n];
+ n += 2;
+ *extra_off = n;
+ while(len){
+ if(n >= size) return 0;
+ n ++;
+ len --;
+ }
+ *extra_len = n - (*extra_off);
+ }
+ if(flags & ORIG_NAME) while(n < size && data[n++]);
+ if(flags & COMMENT) while(n < size && data[n++]);
+ if(flags & HEAD_CRC){
+ if(n + 2 > size) return 0;
+ n += 2;
+ }
+ return n;
+}
+
+#ifdef _USE_KNETFILE
+static RAZF* razf_open_r(knetFile *fp, int _load_index){
+#else
+static RAZF* razf_open_r(int fd, int _load_index){
+#endif
+ RAZF *rz;
+ int ext_off, ext_len;
+ int n, is_be, ret;
+ int64_t end;
+ unsigned char c[] = "RAZF";
+ rz = calloc(1, sizeof(RAZF));
+ rz->mode = 'r';
+#ifdef _USE_KNETFILE
+ rz->x.fpr = fp;
+#else
+#ifdef _WIN32
+ setmode(fd, O_BINARY);
+#endif
+ rz->filedes = fd;
+#endif
+ rz->stream = calloc(sizeof(z_stream), 1);
+ rz->inbuf = malloc(RZ_BUFFER_SIZE);
+ rz->outbuf = malloc(RZ_BUFFER_SIZE);
+ rz->end = rz->src_end = 0x7FFFFFFFFFFFFFFFLL;
+#ifdef _USE_KNETFILE
+ n = knet_read(rz->x.fpr, rz->inbuf, RZ_BUFFER_SIZE);
+#else
+ n = read(rz->filedes, rz->inbuf, RZ_BUFFER_SIZE);
+#endif
+ ret = _read_gz_header(rz->inbuf, n, &ext_off, &ext_len);
+ if(ret == 0){
+ PLAIN_FILE:
+ rz->in = n;
+ rz->file_type = FILE_TYPE_PLAIN;
+ memcpy(rz->outbuf, rz->inbuf, n);
+ rz->buf_len = n;
+ free(rz->stream);
+ rz->stream = NULL;
+ return rz;
+ }
+ rz->header_size = ret;
+ ret = inflateInit2(rz->stream, -WINDOW_BITS);
+ if(ret != Z_OK){ inflateEnd(rz->stream); goto PLAIN_FILE;}
+ rz->stream->avail_in = n - rz->header_size;
+ rz->stream->next_in = rz->inbuf + rz->header_size;
+ rz->stream->avail_out = RZ_BUFFER_SIZE;
+ rz->stream->next_out = rz->outbuf;
+ rz->file_type = FILE_TYPE_GZ;
+ rz->in = rz->header_size;
+ rz->block_pos = rz->header_size;
+ rz->next_block_pos = rz->header_size;
+ rz->block_off = 0;
+ if(ext_len < 7 || memcmp(rz->inbuf + ext_off, c, 4) != 0) return rz;
+ if(((((unsigned char*)rz->inbuf)[ext_off + 5] << 8) | ((unsigned char*)rz->inbuf)[ext_off + 6]) != RZ_BLOCK_SIZE){
+ fprintf(pysamerr, " -- WARNING: RZ_BLOCK_SIZE is not %d, treat source as gz file. in %s -- %s:%d --\n", RZ_BLOCK_SIZE, __FUNCTION__, __FILE__, __LINE__);
+ return rz;
+ }
+ rz->load_index = _load_index;
+ rz->file_type = FILE_TYPE_RZ;
+#ifdef _USE_KNETFILE
+ if(knet_seek(fp, -16, SEEK_END) == -1){
+#else
+ if(lseek(fd, -16, SEEK_END) == -1){
+#endif
+ UNSEEKABLE:
+ rz->seekable = 0;
+ rz->index = NULL;
+ rz->src_end = rz->end = 0x7FFFFFFFFFFFFFFFLL;
+ } else {
+ is_be = is_big_endian();
+ rz->seekable = 1;
+#ifdef _USE_KNETFILE
+ knet_read(fp, &end, sizeof(int64_t));
+#else
+ read(fd, &end, sizeof(int64_t));
+#endif
+ if(!is_be) rz->src_end = (int64_t)byte_swap_8((uint64_t)end);
+ else rz->src_end = end;
+
+#ifdef _USE_KNETFILE
+ knet_read(fp, &end, sizeof(int64_t));
+#else
+ read(fd, &end, sizeof(int64_t));
+#endif
+ if(!is_be) rz->end = (int64_t)byte_swap_8((uint64_t)end);
+ else rz->end = end;
+ if(n > rz->end){
+ rz->stream->avail_in -= n - rz->end;
+ n = rz->end;
+ }
+ if(rz->end > rz->src_end){
+#ifdef _USE_KNETFILE
+ knet_seek(fp, rz->in, SEEK_SET);
+#else
+ lseek(fd, rz->in, SEEK_SET);
+#endif
+ goto UNSEEKABLE;
+ }
+#ifdef _USE_KNETFILE
+ knet_seek(fp, rz->end, SEEK_SET);
+ if(knet_tell(fp) != rz->end){
+ knet_seek(fp, rz->in, SEEK_SET);
+#else
+ if(lseek(fd, rz->end, SEEK_SET) != rz->end){
+ lseek(fd, rz->in, SEEK_SET);
+#endif
+ goto UNSEEKABLE;
+ }
+#ifdef _USE_KNETFILE
+ load_zindex(rz, fp);
+ knet_seek(fp, n, SEEK_SET);
+#else
+ load_zindex(rz, fd);
+ lseek(fd, n, SEEK_SET);
+#endif
+ }
+ return rz;
+}
+
+#ifdef _USE_KNETFILE
+RAZF* razf_dopen(int fd, const char *mode){
+ if (strstr(mode, "r")) fprintf(pysamerr,"[razf_dopen] implement me\n");
+ else if(strstr(mode, "w")) return razf_open_w(fd);
+ return NULL;
+}
+
+RAZF* razf_dopen2(int fd, const char *mode)
+{
+ fprintf(pysamerr,"[razf_dopen2] implement me\n");
+ return NULL;
+}
+#else
+RAZF* razf_dopen(int fd, const char *mode){
+ if(strstr(mode, "r")) return razf_open_r(fd, 1);
+ else if(strstr(mode, "w")) return razf_open_w(fd);
+ else return NULL;
+}
+
+RAZF* razf_dopen2(int fd, const char *mode)
+{
+ if(strstr(mode, "r")) return razf_open_r(fd, 0);
+ else if(strstr(mode, "w")) return razf_open_w(fd);
+ else return NULL;
+}
+#endif
+
+static inline RAZF* _razf_open(const char *filename, const char *mode, int _load_index){
+ int fd;
+ RAZF *rz;
+ if(strstr(mode, "r")){
+#ifdef _USE_KNETFILE
+ knetFile *fd = knet_open(filename, "r");
+ if (fd == 0) {
+ fprintf(pysamerr, "[_razf_open] fail to open %s\n", filename);
+ return NULL;
+ }
+#else
+#ifdef _WIN32
+ fd = open(filename, O_RDONLY | O_BINARY);
+#else
+ fd = open(filename, O_RDONLY);
+#endif
+#endif
+ if(fd < 0) return NULL;
+ rz = razf_open_r(fd, _load_index);
+ } else if(strstr(mode, "w")){
+#ifdef _WIN32
+ fd = open(filename, O_WRONLY | O_CREAT | O_TRUNC | O_BINARY, 0666);
+#else
+ fd = open(filename, O_WRONLY | O_CREAT | O_TRUNC, 0666);
+#endif
+ if(fd < 0) return NULL;
+ rz = razf_open_w(fd);
+ } else return NULL;
+ return rz;
+}
+
+RAZF* razf_open(const char *filename, const char *mode){
+ return _razf_open(filename, mode, 1);
+}
+
+RAZF* razf_open2(const char *filename, const char *mode){
+ return _razf_open(filename, mode, 0);
+}
+
+int razf_get_data_size(RAZF *rz, int64_t *u_size, int64_t *c_size){
+ int64_t n;
+ if(rz->mode != 'r' && rz->mode != 'R') return 0;
+ switch(rz->file_type){
+ case FILE_TYPE_PLAIN:
+ if(rz->end == 0x7fffffffffffffffLL){
+#ifdef _USE_KNETFILE
+ if(knet_seek(rz->x.fpr, 0, SEEK_CUR) == -1) return 0;
+ n = knet_tell(rz->x.fpr);
+ knet_seek(rz->x.fpr, 0, SEEK_END);
+ rz->end = knet_tell(rz->x.fpr);
+ knet_seek(rz->x.fpr, n, SEEK_SET);
+#else
+ if((n = lseek(rz->filedes, 0, SEEK_CUR)) == -1) return 0;
+ rz->end = lseek(rz->filedes, 0, SEEK_END);
+ lseek(rz->filedes, n, SEEK_SET);
+#endif
+ }
+ *u_size = *c_size = rz->end;
+ return 1;
+ case FILE_TYPE_GZ:
+ return 0;
+ case FILE_TYPE_RZ:
+ if(rz->src_end == rz->end) return 0;
+ *u_size = rz->src_end;
+ *c_size = rz->end;
+ return 1;
+ default:
+ return 0;
+ }
+}
+
+static int _razf_read(RAZF* rz, void *data, int size){
+ int ret, tin;
+ if(rz->z_eof || rz->z_err) return 0;
+ if (rz->file_type == FILE_TYPE_PLAIN) {
+#ifdef _USE_KNETFILE
+ ret = knet_read(rz->x.fpr, data, size);
+#else
+ ret = read(rz->filedes, data, size);
+#endif
+ if (ret == 0) rz->z_eof = 1;
+ return ret;
+ }
+ rz->stream->avail_out = size;
+ rz->stream->next_out = data;
+ while(rz->stream->avail_out){
+ if(rz->stream->avail_in == 0){
+ if(rz->in >= rz->end){ rz->z_eof = 1; break; }
+ if(rz->end - rz->in < RZ_BUFFER_SIZE){
+#ifdef _USE_KNETFILE
+ rz->stream->avail_in = knet_read(rz->x.fpr, rz->inbuf, rz->end -rz->in);
+#else
+ rz->stream->avail_in = read(rz->filedes, rz->inbuf, rz->end -rz->in);
+#endif
+ } else {
+#ifdef _USE_KNETFILE
+ rz->stream->avail_in = knet_read(rz->x.fpr, rz->inbuf, RZ_BUFFER_SIZE);
+#else
+ rz->stream->avail_in = read(rz->filedes, rz->inbuf, RZ_BUFFER_SIZE);
+#endif
+ }
+ if(rz->stream->avail_in == 0){
+ rz->z_eof = 1;
+ break;
+ }
+ rz->stream->next_in = rz->inbuf;
+ }
+ tin = rz->stream->avail_in;
+ ret = inflate(rz->stream, Z_BLOCK);
+ rz->in += tin - rz->stream->avail_in;
+ if(ret == Z_NEED_DICT || ret == Z_MEM_ERROR || ret == Z_DATA_ERROR){
+ fprintf(pysamerr, "[_razf_read] inflate error: %d %s (at %s:%d)\n", ret, rz->stream->msg ? rz->stream->msg : "", __FILE__, __LINE__);
+ rz->z_err = 1;
+ break;
+ }
+ if(ret == Z_STREAM_END){
+ rz->z_eof = 1;
+ break;
+ }
+ if ((rz->stream->data_type&128) && !(rz->stream->data_type&64)){
+ rz->buf_flush = 1;
+ rz->next_block_pos = rz->in;
+ break;
+ }
+ }
+ return size - rz->stream->avail_out;
+}
+
+int razf_read(RAZF *rz, void *data, int size){
+ int ori_size, i;
+ ori_size = size;
+ while(size > 0){
+ if(rz->buf_len){
+ if(size < rz->buf_len){
+ for(i=0;i<size;i++) ((char*)data)[i] = ((char*)rz->outbuf + rz->buf_off)[i];
+ rz->buf_off += size;
+ rz->buf_len -= size;
+ data += size;
+ rz->block_off += size;
+ size = 0;
+ break;
+ } else {
+ for(i=0;i<rz->buf_len;i++) ((char*)data)[i] = ((char*)rz->outbuf + rz->buf_off)[i];
+ data += rz->buf_len;
+ size -= rz->buf_len;
+ rz->block_off += rz->buf_len;
+ rz->buf_off = 0;
+ rz->buf_len = 0;
+ if(rz->buf_flush){
+ rz->block_pos = rz->next_block_pos;
+ rz->block_off = 0;
+ rz->buf_flush = 0;
+ }
+ }
+ } else if(rz->buf_flush){
+ rz->block_pos = rz->next_block_pos;
+ rz->block_off = 0;
+ rz->buf_flush = 0;
+ }
+ if(rz->buf_flush) continue;
+ rz->buf_len = _razf_read(rz, rz->outbuf, RZ_BUFFER_SIZE);
+ if(rz->z_eof && rz->buf_len == 0) break;
+ }
+ rz->out += ori_size - size;
+ return ori_size - size;
+}
+
+int razf_skip(RAZF* rz, int size){
+ int ori_size;
+ ori_size = size;
+ while(size > 0){
+ if(rz->buf_len){
+ if(size < rz->buf_len){
+ rz->buf_off += size;
+ rz->buf_len -= size;
+ rz->block_off += size;
+ size = 0;
+ break;
+ } else {
+ size -= rz->buf_len;
+ rz->buf_off = 0;
+ rz->buf_len = 0;
+ rz->block_off += rz->buf_len;
+ if(rz->buf_flush){
+ rz->block_pos = rz->next_block_pos;
+ rz->block_off = 0;
+ rz->buf_flush = 0;
+ }
+ }
+ } else if(rz->buf_flush){
+ rz->block_pos = rz->next_block_pos;
+ rz->block_off = 0;
+ rz->buf_flush = 0;
+ }
+ if(rz->buf_flush) continue;
+ rz->buf_len = _razf_read(rz, rz->outbuf, RZ_BUFFER_SIZE);
+ if(rz->z_eof || rz->z_err) break;
+ }
+ rz->out += ori_size - size;
+ return ori_size - size;
+}
+
+static void _razf_reset_read(RAZF *rz, int64_t in, int64_t out){
+#ifdef _USE_KNETFILE
+ knet_seek(rz->x.fpr, in, SEEK_SET);
+#else
+ lseek(rz->filedes, in, SEEK_SET);
+#endif
+ rz->in = in;
+ rz->out = out;
+ rz->block_pos = in;
+ rz->next_block_pos = in;
+ rz->block_off = 0;
+ rz->buf_flush = 0;
+ rz->z_eof = rz->z_err = 0;
+ inflateReset(rz->stream);
+ rz->stream->avail_in = 0;
+ rz->buf_off = rz->buf_len = 0;
+}
+
+int64_t razf_jump(RAZF *rz, int64_t block_start, int block_offset){
+ int64_t pos;
+ rz->z_eof = 0;
+ if(rz->file_type == FILE_TYPE_PLAIN){
+ rz->buf_off = rz->buf_len = 0;
+ pos = block_start + block_offset;
+#ifdef _USE_KNETFILE
+ knet_seek(rz->x.fpr, pos, SEEK_SET);
+ pos = knet_tell(rz->x.fpr);
+#else
+ pos = lseek(rz->filedes, pos, SEEK_SET);
+#endif
+ rz->out = rz->in = pos;
+ return pos;
+ }
+ if(block_start == rz->block_pos && block_offset >= rz->block_off) {
+ block_offset -= rz->block_off;
+ goto SKIP; // Needn't reset inflate
+ }
+ if(block_start == 0) block_start = rz->header_size; // Automaticly revist wrong block_start
+ _razf_reset_read(rz, block_start, 0);
+ SKIP:
+ if(block_offset) razf_skip(rz, block_offset);
+ return rz->block_off;
+}
+
+int64_t razf_seek(RAZF* rz, int64_t pos, int where){
+ int64_t idx;
+ int64_t seek_pos, new_out;
+ rz->z_eof = 0;
+ if (where == SEEK_CUR) pos += rz->out;
+ else if (where == SEEK_END) pos += rz->src_end;
+ if(rz->file_type == FILE_TYPE_PLAIN){
+#ifdef _USE_KNETFILE
+ knet_seek(rz->x.fpr, pos, SEEK_SET);
+ seek_pos = knet_tell(rz->x.fpr);
+#else
+ seek_pos = lseek(rz->filedes, pos, SEEK_SET);
+#endif
+ rz->buf_off = rz->buf_len = 0;
+ rz->out = rz->in = seek_pos;
+ return seek_pos;
+ } else if(rz->file_type == FILE_TYPE_GZ){
+ if(pos >= rz->out) goto SKIP;
+ return rz->out;
+ }
+ if(pos == rz->out) return pos;
+ if(pos > rz->src_end) return rz->out;
+ if(!rz->seekable || !rz->load_index){
+ if(pos >= rz->out) goto SKIP;
+ }
+ idx = pos / RZ_BLOCK_SIZE - 1;
+ seek_pos = (idx < 0)? rz->header_size:(rz->index->cell_offsets[idx] + rz->index->bin_offsets[idx / RZ_BIN_SIZE]);
+ new_out = (idx + 1) * RZ_BLOCK_SIZE;
+ if(pos > rz->out && new_out <= rz->out) goto SKIP;
+ _razf_reset_read(rz, seek_pos, new_out);
+ SKIP:
+ razf_skip(rz, (int)(pos - rz->out));
+ return rz->out;
+}
+
+uint64_t razf_tell2(RAZF *rz)
+{
+ /*
+ if (rz->load_index) {
+ int64_t idx, seek_pos;
+ idx = rz->out / RZ_BLOCK_SIZE - 1;
+ seek_pos = (idx < 0)? rz->header_size:(rz->index->cell_offsets[idx] + rz->index->bin_offsets[idx / RZ_BIN_SIZE]);
+ if (seek_pos != rz->block_pos || rz->out%RZ_BLOCK_SIZE != rz->block_off)
+ fprintf(pysamerr, "[razf_tell2] inconsistent block offset: (%lld, %lld) != (%lld, %lld)\n",
+ (long long)seek_pos, (long long)rz->out%RZ_BLOCK_SIZE, (long long)rz->block_pos, (long long) rz->block_off);
+ }
+ */
+ return (uint64_t)rz->block_pos<<16 | (rz->block_off&0xffff);
+}
+
+int64_t razf_seek2(RAZF *rz, uint64_t voffset, int where)
+{
+ if (where != SEEK_SET) return -1;
+ return razf_jump(rz, voffset>>16, voffset&0xffff);
+}
+
+void razf_close(RAZF *rz){
+ if(rz->mode == 'w'){
+#ifndef _RZ_READONLY
+ razf_end_flush(rz);
+ deflateEnd(rz->stream);
+#ifdef _USE_KNETFILE
+ save_zindex(rz, rz->x.fpw);
+ if(is_big_endian()){
+ write(rz->x.fpw, &rz->in, sizeof(int64_t));
+ write(rz->x.fpw, &rz->out, sizeof(int64_t));
+ } else {
+ uint64_t v64 = byte_swap_8((uint64_t)rz->in);
+ write(rz->x.fpw, &v64, sizeof(int64_t));
+ v64 = byte_swap_8((uint64_t)rz->out);
+ write(rz->x.fpw, &v64, sizeof(int64_t));
+ }
+#else
+ save_zindex(rz, rz->filedes);
+ if(is_big_endian()){
+ write(rz->filedes, &rz->in, sizeof(int64_t));
+ write(rz->filedes, &rz->out, sizeof(int64_t));
+ } else {
+ uint64_t v64 = byte_swap_8((uint64_t)rz->in);
+ write(rz->filedes, &v64, sizeof(int64_t));
+ v64 = byte_swap_8((uint64_t)rz->out);
+ write(rz->filedes, &v64, sizeof(int64_t));
+ }
+#endif
+#endif
+ } else if(rz->mode == 'r'){
+ if(rz->stream) inflateEnd(rz->stream);
+ }
+ if(rz->inbuf) free(rz->inbuf);
+ if(rz->outbuf) free(rz->outbuf);
+ if(rz->header){
+ free(rz->header->extra);
+ free(rz->header->name);
+ free(rz->header->comment);
+ free(rz->header);
+ }
+ if(rz->index){
+ free(rz->index->bin_offsets);
+ free(rz->index->cell_offsets);
+ free(rz->index);
+ }
+ free(rz->stream);
+#ifdef _USE_KNETFILE
+ if (rz->mode == 'r')
+ knet_close(rz->x.fpr);
+ if (rz->mode == 'w')
+ close(rz->x.fpw);
+#else
+ close(rz->filedes);
+#endif
+ free(rz);
+}
+
+#endif
+++ /dev/null
-#include <string.h>
-#include <unistd.h>
-#include "faidx.h"
-#include "sam.h"
-
-#define TYPE_BAM 1
-#define TYPE_READ 2
-
-bam_header_t *bam_header_dup(const bam_header_t *h0)
-{
- bam_header_t *h;
- int i;
- h = bam_header_init();
- *h = *h0;
- h->hash = h->dict = h->rg2lib = 0;
- h->text = (char*)calloc(h->l_text + 1, 1);
- memcpy(h->text, h0->text, h->l_text);
- h->target_len = (uint32_t*)calloc(h->n_targets, 4);
- h->target_name = (char**)calloc(h->n_targets, sizeof(void*));
- for (i = 0; i < h->n_targets; ++i) {
- h->target_len[i] = h0->target_len[i];
- h->target_name[i] = strdup(h0->target_name[i]);
- }
- return h;
-}
-static void append_header_text(bam_header_t *header, char* text, int len)
-{
- int x = header->l_text + 1;
- int y = header->l_text + len + 1; // 1 byte null
- if (text == 0) return;
- kroundup32(x);
- kroundup32(y);
- if (x < y) header->text = (char*)realloc(header->text, y);
- strncpy(header->text + header->l_text, text, len); // we cannot use strcpy() here.
- header->l_text += len;
- header->text[header->l_text] = 0;
-}
-
-samfile_t *samopen(const char *fn, const char *mode, const void *aux)
-{
- samfile_t *fp;
- fp = (samfile_t*)calloc(1, sizeof(samfile_t));
- if (mode[0] == 'r') { // read
- fp->type |= TYPE_READ;
- if (mode[1] == 'b') { // binary
- fp->type |= TYPE_BAM;
- fp->x.bam = strcmp(fn, "-")? bam_open(fn, "r") : bam_dopen(fileno(stdin), "r");
- if (fp->x.bam == 0) goto open_err_ret;
- fp->header = bam_header_read(fp->x.bam);
- } else { // text
- fp->x.tamr = sam_open(fn);
- if (fp->x.tamr == 0) goto open_err_ret;
- fp->header = sam_header_read(fp->x.tamr);
- if (fp->header->n_targets == 0) { // no @SQ fields
- if (aux) { // check if aux is present
- bam_header_t *textheader = fp->header;
- fp->header = sam_header_read2((const char*)aux);
- if (fp->header == 0) goto open_err_ret;
- append_header_text(fp->header, textheader->text, textheader->l_text);
- bam_header_destroy(textheader);
- }
- if (fp->header->n_targets == 0)
- fprintf(stderr, "[samopen] no @SQ lines in the header.\n");
- } else fprintf(stderr, "[samopen] SAM header is present: %d sequences.\n", fp->header->n_targets);
- }
- } else if (mode[0] == 'w') { // write
- fp->header = bam_header_dup((const bam_header_t*)aux);
- if (mode[1] == 'b') { // binary
- char bmode[3];
- bmode[0] = 'w'; bmode[1] = strstr(mode, "u")? 'u' : 0; bmode[2] = 0;
- fp->type |= TYPE_BAM;
- fp->x.bam = strcmp(fn, "-")? bam_open(fn, bmode) : bam_dopen(fileno(stdout), bmode);
- if (fp->x.bam == 0) goto open_err_ret;
- bam_header_write(fp->x.bam, fp->header);
- } else { // text
- // open file
- fp->x.tamw = strcmp(fn, "-")? fopen(fn, "w") : stdout;
- if (fp->x.tamr == 0) goto open_err_ret;
- if (strstr(mode, "X")) fp->type |= BAM_OFSTR<<2;
- else if (strstr(mode, "x")) fp->type |= BAM_OFHEX<<2;
- else fp->type |= BAM_OFDEC<<2;
- // write header
- if (strstr(mode, "h")) {
- int i;
- bam_header_t *alt;
- // parse the header text
- alt = bam_header_init();
- alt->l_text = fp->header->l_text; alt->text = fp->header->text;
- sam_header_parse(alt);
- alt->l_text = 0; alt->text = 0;
- // check if there are @SQ lines in the header
- fwrite(fp->header->text, 1, fp->header->l_text, fp->x.tamw);
- if (alt->n_targets) { // then write the header text without dumping ->target_{name,len}
- if (alt->n_targets != fp->header->n_targets)
- fprintf(stderr, "[samopen] inconsistent number of target sequences.\n");
- } else { // then dump ->target_{name,len}
- for (i = 0; i < fp->header->n_targets; ++i)
- fprintf(fp->x.tamw, "@SQ\tSN:%s\tLN:%d\n", fp->header->target_name[i], fp->header->target_len[i]);
- }
- bam_header_destroy(alt);
- }
- }
- }
- return fp;
-
-open_err_ret:
- free(fp);
- return 0;
-}
-
-void samclose(samfile_t *fp)
-{
- if (fp == 0) return;
- if (fp->header) bam_header_destroy(fp->header);
- if (fp->type & TYPE_BAM) bam_close(fp->x.bam);
- else if (fp->type & TYPE_READ) sam_close(fp->x.tamr);
- else fclose(fp->x.tamw);
- free(fp);
-}
-
-int samread(samfile_t *fp, bam1_t *b)
-{
- if (fp == 0 || !(fp->type & TYPE_READ)) return -1; // not open for reading
- if (fp->type & TYPE_BAM) return bam_read1(fp->x.bam, b);
- else return sam_read1(fp->x.tamr, fp->header, b);
-}
-
-int samwrite(samfile_t *fp, const bam1_t *b)
-{
- if (fp == 0 || (fp->type & TYPE_READ)) return -1; // not open for writing
- if (fp->type & TYPE_BAM) return bam_write1(fp->x.bam, b);
- else {
- char *s = bam_format1_core(fp->header, b, fp->type>>2&3);
- int l = strlen(s);
- fputs(s, fp->x.tamw); fputc('\n', fp->x.tamw);
- free(s);
- return l + 1;
- }
-}
-
-int sampileup(samfile_t *fp, int mask, bam_pileup_f func, void *func_data)
-{
- bam_plbuf_t *buf;
- int ret;
- bam1_t *b;
- b = bam_init1();
- buf = bam_plbuf_init(func, func_data);
- bam_plbuf_set_mask(buf, mask);
- while ((ret = samread(fp, b)) >= 0)
- bam_plbuf_push(b, buf);
- bam_plbuf_push(0, buf);
- bam_plbuf_destroy(buf);
- bam_destroy1(b);
- return 0;
-}
-
-char *samfaipath(const char *fn_ref)
-{
- char *fn_list = 0;
- if (fn_ref == 0) return 0;
- fn_list = calloc(strlen(fn_ref) + 5, 1);
- strcat(strcpy(fn_list, fn_ref), ".fai");
- if (access(fn_list, R_OK) == -1) { // fn_list is unreadable
- if (access(fn_ref, R_OK) == -1) {
- fprintf(stderr, "[samfaipath] fail to read file %s.\n", fn_ref);
- } else {
- fprintf(stderr, "[samfaipath] build FASTA index...\n");
- if (fai_build(fn_ref) == -1) {
- fprintf(stderr, "[samfaipath] fail to build FASTA index.\n");
- free(fn_list); fn_list = 0;
- }
- }
- }
- return fn_list;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <string.h>
+#include <unistd.h>
+#include "faidx.h"
+#include "sam.h"
+
+#define TYPE_BAM 1
+#define TYPE_READ 2
+
+bam_header_t *bam_header_dup(const bam_header_t *h0)
+{
+ bam_header_t *h;
+ int i;
+ h = bam_header_init();
+ *h = *h0;
+ h->hash = h->dict = h->rg2lib = 0;
+ h->text = (char*)calloc(h->l_text + 1, 1);
+ memcpy(h->text, h0->text, h->l_text);
+ h->target_len = (uint32_t*)calloc(h->n_targets, 4);
+ h->target_name = (char**)calloc(h->n_targets, sizeof(void*));
+ for (i = 0; i < h->n_targets; ++i) {
+ h->target_len[i] = h0->target_len[i];
+ h->target_name[i] = strdup(h0->target_name[i]);
+ }
+ return h;
+}
+static void append_header_text(bam_header_t *header, char* text, int len)
+{
+ int x = header->l_text + 1;
+ int y = header->l_text + len + 1; // 1 byte null
+ if (text == 0) return;
+ kroundup32(x);
+ kroundup32(y);
+ if (x < y) header->text = (char*)realloc(header->text, y);
+ strncpy(header->text + header->l_text, text, len); // we cannot use strcpy() here.
+ header->l_text += len;
+ header->text[header->l_text] = 0;
+}
+
+samfile_t *samopen(const char *fn, const char *mode, const void *aux)
+{
+ samfile_t *fp;
+ fp = (samfile_t*)calloc(1, sizeof(samfile_t));
+ if (strchr(mode, 'r')) { // read
+ fp->type |= TYPE_READ;
+ if (strchr(mode, 'b')) { // binary
+ fp->type |= TYPE_BAM;
+ fp->x.bam = strcmp(fn, "-")? bam_open(fn, "r") : bam_dopen(fileno(stdin), "r");
+ if (fp->x.bam == 0) goto open_err_ret;
+ fp->header = bam_header_read(fp->x.bam);
+ } else { // text
+ fp->x.tamr = sam_open(fn);
+ if (fp->x.tamr == 0) goto open_err_ret;
+ fp->header = sam_header_read(fp->x.tamr);
+ if (fp->header->n_targets == 0) { // no @SQ fields
+ if (aux) { // check if aux is present
+ bam_header_t *textheader = fp->header;
+ fp->header = sam_header_read2((const char*)aux);
+ if (fp->header == 0) goto open_err_ret;
+ append_header_text(fp->header, textheader->text, textheader->l_text);
+ bam_header_destroy(textheader);
+ }
+ if (fp->header->n_targets == 0 && bam_verbose >= 1)
+ fprintf(pysamerr, "[samopen] no @SQ lines in the header.\n");
+ } else if (bam_verbose >= 2) fprintf(pysamerr, "[samopen] SAM header is present: %d sequences.\n", fp->header->n_targets);
+ }
+ } else if (strchr(mode, 'w')) { // write
+ fp->header = bam_header_dup((const bam_header_t*)aux);
+ if (strchr(mode, 'b')) { // binary
+ char bmode[3];
+ int i, compress_level = -1;
+ for (i = 0; mode[i]; ++i) if (mode[i] >= '0' && mode[i] <= '9') break;
+ if (mode[i]) compress_level = mode[i] - '0';
+ if (strchr(mode, 'u')) compress_level = 0;
+ bmode[0] = 'w'; bmode[1] = compress_level < 0? 0 : compress_level + '0'; bmode[2] = 0;
+ fp->type |= TYPE_BAM;
+ fp->x.bam = strcmp(fn, "-")? bam_open(fn, bmode) : bam_dopen(fileno(stdout), bmode);
+ if (fp->x.bam == 0) goto open_err_ret;
+ bam_header_write(fp->x.bam, fp->header);
+ } else { // text
+ // open file
+ fp->x.tamw = strcmp(fn, "-")? fopen(fn, "w") : stdout;
+ if (fp->x.tamr == 0) goto open_err_ret;
+ if (strchr(mode, 'X')) fp->type |= BAM_OFSTR<<2;
+ else if (strchr(mode, 'x')) fp->type |= BAM_OFHEX<<2;
+ else fp->type |= BAM_OFDEC<<2;
+ // write header
+ if (strchr(mode, 'h')) {
+ int i;
+ bam_header_t *alt;
+ // parse the header text
+ alt = bam_header_init();
+ alt->l_text = fp->header->l_text; alt->text = fp->header->text;
+ sam_header_parse(alt);
+ alt->l_text = 0; alt->text = 0;
+ // check if there are @SQ lines in the header
+ fwrite(fp->header->text, 1, fp->header->l_text, fp->x.tamw); // FIXME: better to skip the trailing NULL
+ if (alt->n_targets) { // then write the header text without dumping ->target_{name,len}
+ if (alt->n_targets != fp->header->n_targets && bam_verbose >= 1)
+ fprintf(pysamerr, "[samopen] inconsistent number of target sequences. Output the text header.\n");
+ } else { // then dump ->target_{name,len}
+ for (i = 0; i < fp->header->n_targets; ++i)
+ fprintf(fp->x.tamw, "@SQ\tSN:%s\tLN:%d\n", fp->header->target_name[i], fp->header->target_len[i]);
+ }
+ bam_header_destroy(alt);
+ }
+ }
+ }
+ return fp;
+
+open_err_ret:
+ free(fp);
+ return 0;
+}
+
+void samclose(samfile_t *fp)
+{
+ if (fp == 0) return;
+ if (fp->header) bam_header_destroy(fp->header);
+ if (fp->type & TYPE_BAM) bam_close(fp->x.bam);
+ else if (fp->type & TYPE_READ) sam_close(fp->x.tamr);
+ else fclose(fp->x.tamw);
+ free(fp);
+}
+
+int samread(samfile_t *fp, bam1_t *b)
+{
+ if (fp == 0 || !(fp->type & TYPE_READ)) return -1; // not open for reading
+ if (fp->type & TYPE_BAM) return bam_read1(fp->x.bam, b);
+ else return sam_read1(fp->x.tamr, fp->header, b);
+}
+
+int samwrite(samfile_t *fp, const bam1_t *b)
+{
+ if (fp == 0 || (fp->type & TYPE_READ)) return -1; // not open for writing
+ if (fp->type & TYPE_BAM) return bam_write1(fp->x.bam, b);
+ else {
+ char *s = bam_format1_core(fp->header, b, fp->type>>2&3);
+ int l = strlen(s);
+ fputs(s, fp->x.tamw); fputc('\n', fp->x.tamw);
+ free(s);
+ return l + 1;
+ }
+}
+
+int sampileup(samfile_t *fp, int mask, bam_pileup_f func, void *func_data)
+{
+ bam_plbuf_t *buf;
+ int ret;
+ bam1_t *b;
+ b = bam_init1();
+ buf = bam_plbuf_init(func, func_data);
+ bam_plbuf_set_mask(buf, mask);
+ while ((ret = samread(fp, b)) >= 0)
+ bam_plbuf_push(b, buf);
+ bam_plbuf_push(0, buf);
+ bam_plbuf_destroy(buf);
+ bam_destroy1(b);
+ return 0;
+}
+
+char *samfaipath(const char *fn_ref)
+{
+ char *fn_list = 0;
+ if (fn_ref == 0) return 0;
+ fn_list = calloc(strlen(fn_ref) + 5, 1);
+ strcat(strcpy(fn_list, fn_ref), ".fai");
+ if (access(fn_list, R_OK) == -1) { // fn_list is unreadable
+ if (access(fn_ref, R_OK) == -1) {
+ fprintf(pysamerr, "[samfaipath] fail to read file %s.\n", fn_ref);
+ } else {
+ if (bam_verbose >= 3) fprintf(pysamerr, "[samfaipath] build FASTA index...\n");
+ if (fai_build(fn_ref) == -1) {
+ fprintf(pysamerr, "[samfaipath] fail to build FASTA index.\n");
+ free(fn_list); fn_list = 0;
+ }
+ }
+ }
+ return fn_list;
+}
+++ /dev/null
-#include "sam_header.h"
-#include <stdio.h>
-#include <string.h>
-#include <ctype.h>
-#include <stdlib.h>
-#include <stdarg.h>
-
-#include "khash.h"
-KHASH_MAP_INIT_STR(str, const char *)
-
-struct _HeaderList
-{
- struct _HeaderList *last; // Hack: Used and maintained only by list_append_to_end. Maintained in the root node only.
- struct _HeaderList *next;
- void *data;
-};
-typedef struct _HeaderList list_t;
-typedef list_t HeaderDict;
-
-typedef struct
-{
- char key[2];
- char *value;
-}
-HeaderTag;
-
-typedef struct
-{
- char type[2];
- list_t *tags;
-}
-HeaderLine;
-
-const char *o_hd_tags[] = {"SO","GO",NULL};
-const char *r_hd_tags[] = {"VN",NULL};
-
-const char *o_sq_tags[] = {"AS","M5","UR","SP",NULL};
-const char *r_sq_tags[] = {"SN","LN",NULL};
-const char *u_sq_tags[] = {"SN",NULL};
-
-const char *o_rg_tags[] = {"LB","DS","PU","PI","CN","DT","PL",NULL};
-const char *r_rg_tags[] = {"ID",NULL};
-const char *u_rg_tags[] = {"ID",NULL};
-
-const char *o_pg_tags[] = {"VN","CL",NULL};
-const char *r_pg_tags[] = {"ID",NULL};
-
-const char *types[] = {"HD","SQ","RG","PG","CO",NULL};
-const char **optional_tags[] = {o_hd_tags,o_sq_tags,o_rg_tags,o_pg_tags,NULL,NULL};
-const char **required_tags[] = {r_hd_tags,r_sq_tags,r_rg_tags,r_pg_tags,NULL,NULL};
-const char **unique_tags[] = {NULL, u_sq_tags,u_rg_tags,NULL,NULL,NULL};
-
-
-static void debug(const char *format, ...)
-{
- va_list ap;
- va_start(ap, format);
- vfprintf(stderr, format, ap);
- va_end(ap);
-}
-
-#if 0
-// Replaced by list_append_to_end
-static list_t *list_prepend(list_t *root, void *data)
-{
- list_t *l = malloc(sizeof(list_t));
- l->next = root;
- l->data = data;
- return l;
-}
-#endif
-
-// Relies on the root->last being correct. Do not use with the other list_*
-// routines unless they are fixed to modify root->last as well.
-static list_t *list_append_to_end(list_t *root, void *data)
-{
- list_t *l = malloc(sizeof(list_t));
- l->last = l;
- l->next = NULL;
- l->data = data;
-
- if ( !root )
- return l;
-
- root->last->next = l;
- root->last = l;
- return root;
-}
-
-static list_t *list_append(list_t *root, void *data)
-{
- list_t *l = root;
- while (l && l->next)
- l = l->next;
- if ( l )
- {
- l->next = malloc(sizeof(list_t));
- l = l->next;
- }
- else
- {
- l = malloc(sizeof(list_t));
- root = l;
- }
- l->data = data;
- l->next = NULL;
- return root;
-}
-
-static void list_free(list_t *root)
-{
- list_t *l = root;
- while (root)
- {
- l = root;
- root = root->next;
- free(l);
- }
-}
-
-
-
-// Look for a tag "XY" in a predefined const char *[] array.
-static int tag_exists(const char *tag, const char **tags)
-{
- int itag=0;
- if ( !tags ) return -1;
- while ( tags[itag] )
- {
- if ( tags[itag][0]==tag[0] && tags[itag][1]==tag[1] ) return itag;
- itag++;
- }
- return -1;
-}
-
-
-
-// Mimics the behaviour of getline, except it returns pointer to the next chunk of the text
-// or NULL if everything has been read. The lineptr should be freed by the caller. The
-// newline character is stripped.
-static const char *nextline(char **lineptr, size_t *n, const char *text)
-{
- int len;
- const char *to = text;
-
- if ( !*to ) return NULL;
-
- while ( *to && *to!='\n' && *to!='\r' ) to++;
- len = to - text + 1;
-
- if ( *to )
- {
- // Advance the pointer for the next call
- if ( *to=='\n' ) to++;
- else if ( *to=='\r' && *(to+1)=='\n' ) to+=2;
- }
- if ( !len )
- return to;
-
- if ( !*lineptr )
- {
- *lineptr = malloc(len);
- *n = len;
- }
- else if ( *n<len )
- {
- *lineptr = realloc(*lineptr, len);
- *n = len;
- }
- if ( !*lineptr ) {
- debug("[nextline] Insufficient memory!\n");
- return 0;
- }
-
- memcpy(*lineptr,text,len);
- (*lineptr)[len-1] = 0;
-
- return to;
-}
-
-// name points to "XY", value_from points to the first character of the value string and
-// value_to points to the last character of the value string.
-static HeaderTag *new_tag(const char *name, const char *value_from, const char *value_to)
-{
- HeaderTag *tag = malloc(sizeof(HeaderTag));
- int len = value_to-value_from+1;
-
- tag->key[0] = name[0];
- tag->key[1] = name[1];
- tag->value = malloc(len+1);
- memcpy(tag->value,value_from,len+1);
- tag->value[len] = 0;
- return tag;
-}
-
-static HeaderTag *header_line_has_tag(HeaderLine *hline, const char *key)
-{
- list_t *tags = hline->tags;
- while (tags)
- {
- HeaderTag *tag = tags->data;
- if ( tag->key[0]==key[0] && tag->key[1]==key[1] ) return tag;
- tags = tags->next;
- }
- return NULL;
-}
-
-
-// Return codes:
-// 0 .. different types or unique tags differ or conflicting tags, cannot be merged
-// 1 .. all tags identical -> no need to merge, drop one
-// 2 .. the unique tags match and there are some conflicting tags (same tag, different value) -> error, cannot be merged nor duplicated
-// 3 .. there are some missing complementary tags and no unique conflict -> can be merged into a single line
-static int sam_header_compare_lines(HeaderLine *hline1, HeaderLine *hline2)
-{
- HeaderTag *t1, *t2;
-
- if ( hline1->type[0]!=hline2->type[0] || hline1->type[1]!=hline2->type[1] )
- return 0;
-
- int itype = tag_exists(hline1->type,types);
- if ( itype==-1 ) {
- debug("[sam_header_compare_lines] Unknown type [%c%c]\n", hline1->type[0],hline1->type[1]);
- return -1; // FIXME (lh3): error; I do not know how this will be handled in Petr's code
- }
-
- if ( unique_tags[itype] )
- {
- t1 = header_line_has_tag(hline1,unique_tags[itype][0]);
- t2 = header_line_has_tag(hline2,unique_tags[itype][0]);
- if ( !t1 || !t2 ) // this should never happen, the unique tags are required
- return 2;
-
- if ( strcmp(t1->value,t2->value) )
- return 0; // the unique tags differ, cannot be merged
- }
- if ( !required_tags[itype] && !optional_tags[itype] )
- {
- t1 = hline1->tags->data;
- t2 = hline2->tags->data;
- if ( !strcmp(t1->value,t2->value) ) return 1; // identical comments
- return 0;
- }
-
- int missing=0, itag=0;
- while ( required_tags[itype] && required_tags[itype][itag] )
- {
- t1 = header_line_has_tag(hline1,required_tags[itype][itag]);
- t2 = header_line_has_tag(hline2,required_tags[itype][itag]);
- if ( !t1 && !t2 )
- return 2; // this should never happen
- else if ( !t1 || !t2 )
- missing = 1; // there is some tag missing in one of the hlines
- else if ( strcmp(t1->value,t2->value) )
- {
- if ( unique_tags[itype] )
- return 2; // the lines have a matching unique tag but have a conflicting tag
-
- return 0; // the lines contain conflicting tags, cannot be merged
- }
- itag++;
- }
- itag = 0;
- while ( optional_tags[itype] && optional_tags[itype][itag] )
- {
- t1 = header_line_has_tag(hline1,optional_tags[itype][itag]);
- t2 = header_line_has_tag(hline2,optional_tags[itype][itag]);
- if ( !t1 && !t2 )
- {
- itag++;
- continue;
- }
- if ( !t1 || !t2 )
- missing = 1; // there is some tag missing in one of the hlines
- else if ( strcmp(t1->value,t2->value) )
- {
- if ( unique_tags[itype] )
- return 2; // the lines have a matching unique tag but have a conflicting tag
-
- return 0; // the lines contain conflicting tags, cannot be merged
- }
- itag++;
- }
- if ( missing ) return 3; // there are some missing complementary tags with no conflicts, can be merged
- return 1;
-}
-
-
-static HeaderLine *sam_header_line_clone(const HeaderLine *hline)
-{
- list_t *tags;
- HeaderLine *out = malloc(sizeof(HeaderLine));
- out->type[0] = hline->type[0];
- out->type[1] = hline->type[1];
- out->tags = NULL;
-
- tags = hline->tags;
- while (tags)
- {
- HeaderTag *old = tags->data;
-
- HeaderTag *new = malloc(sizeof(HeaderTag));
- new->key[0] = old->key[0];
- new->key[1] = old->key[1];
- new->value = strdup(old->value);
- out->tags = list_append(out->tags, new);
-
- tags = tags->next;
- }
- return out;
-}
-
-static int sam_header_line_merge_with(HeaderLine *out_hline, const HeaderLine *tmpl_hline)
-{
- list_t *tmpl_tags;
-
- if ( out_hline->type[0]!=tmpl_hline->type[0] || out_hline->type[1]!=tmpl_hline->type[1] )
- return 0;
-
- tmpl_tags = tmpl_hline->tags;
- while (tmpl_tags)
- {
- HeaderTag *tmpl_tag = tmpl_tags->data;
- HeaderTag *out_tag = header_line_has_tag(out_hline, tmpl_tag->key);
- if ( !out_tag )
- {
- HeaderTag *tag = malloc(sizeof(HeaderTag));
- tag->key[0] = tmpl_tag->key[0];
- tag->key[1] = tmpl_tag->key[1];
- tag->value = strdup(tmpl_tag->value);
- out_hline->tags = list_append(out_hline->tags,tag);
- }
- tmpl_tags = tmpl_tags->next;
- }
- return 1;
-}
-
-
-static HeaderLine *sam_header_line_parse(const char *headerLine)
-{
- HeaderLine *hline;
- HeaderTag *tag;
- const char *from, *to;
- from = headerLine;
-
- if ( *from != '@' ) {
- debug("[sam_header_line_parse] expected '@', got [%s]\n", headerLine);
- return 0;
- }
- to = ++from;
-
- while (*to && *to!='\t') to++;
- if ( to-from != 2 ) {
- debug("[sam_header_line_parse] expected '@XY', got [%s]\nHint: The header tags must be tab-separated.\n", headerLine);
- return 0;
- }
-
- hline = malloc(sizeof(HeaderLine));
- hline->type[0] = from[0];
- hline->type[1] = from[1];
- hline->tags = NULL;
-
- int itype = tag_exists(hline->type, types);
-
- from = to;
- while (*to && *to=='\t') to++;
- if ( to-from != 1 ) {
- debug("[sam_header_line_parse] multiple tabs on line [%s] (%d)\n", headerLine,(int)(to-from));
- return 0;
- }
- from = to;
- while (*from)
- {
- while (*to && *to!='\t') to++;
-
- if ( !required_tags[itype] && !optional_tags[itype] )
- {
- // CO is a special case, it can contain anything, including tabs
- if ( *to ) { to++; continue; }
- tag = new_tag(" ",from,to-1);
- }
- else
- tag = new_tag(from,from+3,to-1);
-
- if ( header_line_has_tag(hline,tag->key) )
- debug("The tag '%c%c' present (at least) twice on line [%s]\n", tag->key[0],tag->key[1], headerLine);
- hline->tags = list_append(hline->tags, tag);
-
- from = to;
- while (*to && *to=='\t') to++;
- if ( *to && to-from != 1 ) {
- debug("[sam_header_line_parse] multiple tabs on line [%s] (%d)\n", headerLine,(int)(to-from));
- return 0;
- }
-
- from = to;
- }
- return hline;
-}
-
-
-// Must be of an existing type, all tags must be recognised and all required tags must be present
-static int sam_header_line_validate(HeaderLine *hline)
-{
- list_t *tags;
- HeaderTag *tag;
- int itype, itag;
-
- // Is the type correct?
- itype = tag_exists(hline->type, types);
- if ( itype==-1 )
- {
- debug("The type [%c%c] not recognised.\n", hline->type[0],hline->type[1]);
- return 0;
- }
-
- // Has all required tags?
- itag = 0;
- while ( required_tags[itype] && required_tags[itype][itag] )
- {
- if ( !header_line_has_tag(hline,required_tags[itype][itag]) )
- {
- debug("The tag [%c%c] required for [%c%c] not present.\n", required_tags[itype][itag][0],required_tags[itype][itag][1],
- hline->type[0],hline->type[1]);
- return 0;
- }
- itag++;
- }
-
- // Are all tags recognised?
- tags = hline->tags;
- while ( tags )
- {
- tag = tags->data;
- if ( !tag_exists(tag->key,required_tags[itype]) && !tag_exists(tag->key,optional_tags[itype]) )
- {
- debug("Unknown tag [%c%c] for [%c%c].\n", tag->key[0],tag->key[1], hline->type[0],hline->type[1]);
- return 0;
- }
- tags = tags->next;
- }
-
- return 1;
-}
-
-
-static void print_header_line(FILE *fp, HeaderLine *hline)
-{
- list_t *tags = hline->tags;
- HeaderTag *tag;
-
- fprintf(fp, "@%c%c", hline->type[0],hline->type[1]);
- while (tags)
- {
- tag = tags->data;
-
- fprintf(fp, "\t");
- if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
- fprintf(fp, "%c%c:", tag->key[0],tag->key[1]);
- fprintf(fp, "%s", tag->value);
-
- tags = tags->next;
- }
- fprintf(fp,"\n");
-}
-
-
-static void sam_header_line_free(HeaderLine *hline)
-{
- list_t *tags = hline->tags;
- while (tags)
- {
- HeaderTag *tag = tags->data;
- free(tag->value);
- free(tag);
- tags = tags->next;
- }
- list_free(hline->tags);
- free(hline);
-}
-
-void sam_header_free(void *_header)
-{
- HeaderDict *header = (HeaderDict*)_header;
- list_t *hlines = header;
- while (hlines)
- {
- sam_header_line_free(hlines->data);
- hlines = hlines->next;
- }
- list_free(header);
-}
-
-HeaderDict *sam_header_clone(const HeaderDict *dict)
-{
- HeaderDict *out = NULL;
- while (dict)
- {
- HeaderLine *hline = dict->data;
- out = list_append(out, sam_header_line_clone(hline));
- dict = dict->next;
- }
- return out;
-}
-
-// Returns a newly allocated string
-char *sam_header_write(const void *_header)
-{
- const HeaderDict *header = (const HeaderDict*)_header;
- char *out = NULL;
- int len=0, nout=0;
- const list_t *hlines;
-
- // Calculate the length of the string to allocate
- hlines = header;
- while (hlines)
- {
- len += 4; // @XY and \n
-
- HeaderLine *hline = hlines->data;
- list_t *tags = hline->tags;
- while (tags)
- {
- HeaderTag *tag = tags->data;
- len += strlen(tag->value) + 1; // \t
- if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
- len += strlen(tag->value) + 3; // XY:
- tags = tags->next;
- }
- hlines = hlines->next;
- }
-
- nout = 0;
- out = malloc(len+1);
- hlines = header;
- while (hlines)
- {
- HeaderLine *hline = hlines->data;
-
- nout += sprintf(out+nout,"@%c%c",hline->type[0],hline->type[1]);
-
- list_t *tags = hline->tags;
- while (tags)
- {
- HeaderTag *tag = tags->data;
- nout += sprintf(out+nout,"\t");
- if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
- nout += sprintf(out+nout,"%c%c:", tag->key[0],tag->key[1]);
- nout += sprintf(out+nout,"%s", tag->value);
- tags = tags->next;
- }
- hlines = hlines->next;
- nout += sprintf(out+nout,"\n");
- }
- out[len] = 0;
- return out;
-}
-
-void *sam_header_parse2(const char *headerText)
-{
- list_t *hlines = NULL;
- HeaderLine *hline;
- const char *text;
- char *buf=NULL;
- size_t nbuf = 0;
-
- if ( !headerText )
- return 0;
-
- text = headerText;
- while ( (text=nextline(&buf, &nbuf, text)) )
- {
- hline = sam_header_line_parse(buf);
- if ( hline && sam_header_line_validate(hline) )
- // With too many (~250,000) reference sequences the header parsing was too slow with list_append.
- hlines = list_append_to_end(hlines, hline);
- else
- {
- if (hline) sam_header_line_free(hline);
- sam_header_free(hlines);
- if ( buf ) free(buf);
- return NULL;
- }
- }
- if ( buf ) free(buf);
-
- return hlines;
-}
-
-void *sam_header2tbl(const void *_dict, char type[2], char key_tag[2], char value_tag[2])
-{
- const HeaderDict *dict = (const HeaderDict*)_dict;
- const list_t *l = dict;
- khash_t(str) *tbl = kh_init(str);
- khiter_t k;
- int ret;
-
- if (_dict == 0) return tbl; // return an empty (not null) hash table
- while (l)
- {
- HeaderLine *hline = l->data;
- if ( hline->type[0]!=type[0] || hline->type[1]!=type[1] )
- {
- l = l->next;
- continue;
- }
-
- HeaderTag *key, *value;
- key = header_line_has_tag(hline,key_tag);
- value = header_line_has_tag(hline,value_tag);
- if ( !key || !value )
- {
- l = l->next;
- continue;
- }
-
- k = kh_get(str, tbl, key->value);
- if ( k != kh_end(tbl) )
- debug("[sam_header_lookup_table] They key %s not unique.\n", key->value);
- k = kh_put(str, tbl, key->value, &ret);
- kh_value(tbl, k) = value->value;
-
- l = l->next;
- }
- return tbl;
-}
-
-char **sam_header2list(const void *_dict, char type[2], char key_tag[2], int *_n)
-{
- const HeaderDict *dict = (const HeaderDict*)_dict;
- const list_t *l = dict;
- int max, n;
- char **ret;
-
- ret = 0; *_n = max = n = 0;
- while (l)
- {
- HeaderLine *hline = l->data;
- if ( hline->type[0]!=type[0] || hline->type[1]!=type[1] )
- {
- l = l->next;
- continue;
- }
-
- HeaderTag *key;
- key = header_line_has_tag(hline,key_tag);
- if ( !key )
- {
- l = l->next;
- continue;
- }
-
- if (n == max) {
- max = max? max<<1 : 4;
- ret = realloc(ret, max * sizeof(void*));
- }
- ret[n++] = key->value;
-
- l = l->next;
- }
- *_n = n;
- return ret;
-}
-
-const char *sam_tbl_get(void *h, const char *key)
-{
- khash_t(str) *tbl = (khash_t(str)*)h;
- khint_t k;
- k = kh_get(str, tbl, key);
- return k == kh_end(tbl)? 0 : kh_val(tbl, k);
-}
-
-int sam_tbl_size(void *h)
-{
- khash_t(str) *tbl = (khash_t(str)*)h;
- return h? kh_size(tbl) : 0;
-}
-
-void sam_tbl_destroy(void *h)
-{
- khash_t(str) *tbl = (khash_t(str)*)h;
- kh_destroy(str, tbl);
-}
-
-void *sam_header_merge(int n, const void **_dicts)
-{
- const HeaderDict **dicts = (const HeaderDict**)_dicts;
- HeaderDict *out_dict;
- int idict, status;
-
- if ( n<2 ) return NULL;
-
- out_dict = sam_header_clone(dicts[0]);
-
- for (idict=1; idict<n; idict++)
- {
- const list_t *tmpl_hlines = dicts[idict];
-
- while ( tmpl_hlines )
- {
- list_t *out_hlines = out_dict;
- int inserted = 0;
- while ( out_hlines )
- {
- status = sam_header_compare_lines(tmpl_hlines->data, out_hlines->data);
- if ( status==0 )
- {
- out_hlines = out_hlines->next;
- continue;
- }
-
- if ( status==2 )
- {
- print_header_line(stderr,tmpl_hlines->data);
- print_header_line(stderr,out_hlines->data);
- debug("Conflicting lines, cannot merge the headers.\n");
- return 0;
- }
- if ( status==3 )
- sam_header_line_merge_with(out_hlines->data, tmpl_hlines->data);
-
- inserted = 1;
- break;
- }
- if ( !inserted )
- out_dict = list_append(out_dict, sam_header_line_clone(tmpl_hlines->data));
-
- tmpl_hlines = tmpl_hlines->next;
- }
- }
-
- return out_dict;
-}
-
-
--- /dev/null
+#include "pysam.h"
+
+#include "sam_header.h"
+#include <stdio.h>
+#include <string.h>
+#include <ctype.h>
+#include <stdlib.h>
+#include <stdarg.h>
+
+#include "khash.h"
+KHASH_MAP_INIT_STR(str, const char *)
+
+struct _HeaderList
+{
+ struct _HeaderList *last; // Hack: Used and maintained only by list_append_to_end. Maintained in the root node only.
+ struct _HeaderList *next;
+ void *data;
+};
+typedef struct _HeaderList list_t;
+typedef list_t HeaderDict;
+
+typedef struct
+{
+ char key[2];
+ char *value;
+}
+HeaderTag;
+
+typedef struct
+{
+ char type[2];
+ list_t *tags;
+}
+HeaderLine;
+
+const char *o_hd_tags[] = {"SO","GO",NULL};
+const char *r_hd_tags[] = {"VN",NULL};
+
+const char *o_sq_tags[] = {"AS","M5","UR","SP",NULL};
+const char *r_sq_tags[] = {"SN","LN",NULL};
+const char *u_sq_tags[] = {"SN",NULL};
+
+const char *o_rg_tags[] = {"CN","DS","DT","FO","KS","LB","PG","PI","PL","PU","SM",NULL};
+const char *r_rg_tags[] = {"ID",NULL};
+const char *u_rg_tags[] = {"ID",NULL};
+
+const char *o_pg_tags[] = {"VN","CL",NULL};
+const char *r_pg_tags[] = {"ID",NULL};
+
+const char *types[] = {"HD","SQ","RG","PG","CO",NULL};
+const char **optional_tags[] = {o_hd_tags,o_sq_tags,o_rg_tags,o_pg_tags,NULL,NULL};
+const char **required_tags[] = {r_hd_tags,r_sq_tags,r_rg_tags,r_pg_tags,NULL,NULL};
+const char **unique_tags[] = {NULL, u_sq_tags,u_rg_tags,NULL,NULL,NULL};
+
+
+static void debug(const char *format, ...)
+{
+ va_list ap;
+ va_start(ap, format);
+ vfprintf(pysamerr, format, ap);
+ va_end(ap);
+}
+
+#if 0
+// Replaced by list_append_to_end
+static list_t *list_prepend(list_t *root, void *data)
+{
+ list_t *l = malloc(sizeof(list_t));
+ l->next = root;
+ l->data = data;
+ return l;
+}
+#endif
+
+// Relies on the root->last being correct. Do not use with the other list_*
+// routines unless they are fixed to modify root->last as well.
+static list_t *list_append_to_end(list_t *root, void *data)
+{
+ list_t *l = malloc(sizeof(list_t));
+ l->last = l;
+ l->next = NULL;
+ l->data = data;
+
+ if ( !root )
+ return l;
+
+ root->last->next = l;
+ root->last = l;
+ return root;
+}
+
+static list_t *list_append(list_t *root, void *data)
+{
+ list_t *l = root;
+ while (l && l->next)
+ l = l->next;
+ if ( l )
+ {
+ l->next = malloc(sizeof(list_t));
+ l = l->next;
+ }
+ else
+ {
+ l = malloc(sizeof(list_t));
+ root = l;
+ }
+ l->data = data;
+ l->next = NULL;
+ return root;
+}
+
+static void list_free(list_t *root)
+{
+ list_t *l = root;
+ while (root)
+ {
+ l = root;
+ root = root->next;
+ free(l);
+ }
+}
+
+
+
+// Look for a tag "XY" in a predefined const char *[] array.
+static int tag_exists(const char *tag, const char **tags)
+{
+ int itag=0;
+ if ( !tags ) return -1;
+ while ( tags[itag] )
+ {
+ if ( tags[itag][0]==tag[0] && tags[itag][1]==tag[1] ) return itag;
+ itag++;
+ }
+ return -1;
+}
+
+
+
+// Mimics the behaviour of getline, except it returns pointer to the next chunk of the text
+// or NULL if everything has been read. The lineptr should be freed by the caller. The
+// newline character is stripped.
+static const char *nextline(char **lineptr, size_t *n, const char *text)
+{
+ int len;
+ const char *to = text;
+
+ if ( !*to ) return NULL;
+
+ while ( *to && *to!='\n' && *to!='\r' ) to++;
+ len = to - text + 1;
+
+ if ( *to )
+ {
+ // Advance the pointer for the next call
+ if ( *to=='\n' ) to++;
+ else if ( *to=='\r' && *(to+1)=='\n' ) to+=2;
+ }
+ if ( !len )
+ return to;
+
+ if ( !*lineptr )
+ {
+ *lineptr = malloc(len);
+ *n = len;
+ }
+ else if ( *n<len )
+ {
+ *lineptr = realloc(*lineptr, len);
+ *n = len;
+ }
+ if ( !*lineptr ) {
+ debug("[nextline] Insufficient memory!\n");
+ return 0;
+ }
+
+ memcpy(*lineptr,text,len);
+ (*lineptr)[len-1] = 0;
+
+ return to;
+}
+
+// name points to "XY", value_from points to the first character of the value string and
+// value_to points to the last character of the value string.
+static HeaderTag *new_tag(const char *name, const char *value_from, const char *value_to)
+{
+ HeaderTag *tag = malloc(sizeof(HeaderTag));
+ int len = value_to-value_from+1;
+
+ tag->key[0] = name[0];
+ tag->key[1] = name[1];
+ tag->value = malloc(len+1);
+ memcpy(tag->value,value_from,len+1);
+ tag->value[len] = 0;
+ return tag;
+}
+
+static HeaderTag *header_line_has_tag(HeaderLine *hline, const char *key)
+{
+ list_t *tags = hline->tags;
+ while (tags)
+ {
+ HeaderTag *tag = tags->data;
+ if ( tag->key[0]==key[0] && tag->key[1]==key[1] ) return tag;
+ tags = tags->next;
+ }
+ return NULL;
+}
+
+
+// Return codes:
+// 0 .. different types or unique tags differ or conflicting tags, cannot be merged
+// 1 .. all tags identical -> no need to merge, drop one
+// 2 .. the unique tags match and there are some conflicting tags (same tag, different value) -> error, cannot be merged nor duplicated
+// 3 .. there are some missing complementary tags and no unique conflict -> can be merged into a single line
+static int sam_header_compare_lines(HeaderLine *hline1, HeaderLine *hline2)
+{
+ HeaderTag *t1, *t2;
+
+ if ( hline1->type[0]!=hline2->type[0] || hline1->type[1]!=hline2->type[1] )
+ return 0;
+
+ int itype = tag_exists(hline1->type,types);
+ if ( itype==-1 ) {
+ debug("[sam_header_compare_lines] Unknown type [%c%c]\n", hline1->type[0],hline1->type[1]);
+ return -1; // FIXME (lh3): error; I do not know how this will be handled in Petr's code
+ }
+
+ if ( unique_tags[itype] )
+ {
+ t1 = header_line_has_tag(hline1,unique_tags[itype][0]);
+ t2 = header_line_has_tag(hline2,unique_tags[itype][0]);
+ if ( !t1 || !t2 ) // this should never happen, the unique tags are required
+ return 2;
+
+ if ( strcmp(t1->value,t2->value) )
+ return 0; // the unique tags differ, cannot be merged
+ }
+ if ( !required_tags[itype] && !optional_tags[itype] )
+ {
+ t1 = hline1->tags->data;
+ t2 = hline2->tags->data;
+ if ( !strcmp(t1->value,t2->value) ) return 1; // identical comments
+ return 0;
+ }
+
+ int missing=0, itag=0;
+ while ( required_tags[itype] && required_tags[itype][itag] )
+ {
+ t1 = header_line_has_tag(hline1,required_tags[itype][itag]);
+ t2 = header_line_has_tag(hline2,required_tags[itype][itag]);
+ if ( !t1 && !t2 )
+ return 2; // this should never happen
+ else if ( !t1 || !t2 )
+ missing = 1; // there is some tag missing in one of the hlines
+ else if ( strcmp(t1->value,t2->value) )
+ {
+ if ( unique_tags[itype] )
+ return 2; // the lines have a matching unique tag but have a conflicting tag
+
+ return 0; // the lines contain conflicting tags, cannot be merged
+ }
+ itag++;
+ }
+ itag = 0;
+ while ( optional_tags[itype] && optional_tags[itype][itag] )
+ {
+ t1 = header_line_has_tag(hline1,optional_tags[itype][itag]);
+ t2 = header_line_has_tag(hline2,optional_tags[itype][itag]);
+ if ( !t1 && !t2 )
+ {
+ itag++;
+ continue;
+ }
+ if ( !t1 || !t2 )
+ missing = 1; // there is some tag missing in one of the hlines
+ else if ( strcmp(t1->value,t2->value) )
+ {
+ if ( unique_tags[itype] )
+ return 2; // the lines have a matching unique tag but have a conflicting tag
+
+ return 0; // the lines contain conflicting tags, cannot be merged
+ }
+ itag++;
+ }
+ if ( missing ) return 3; // there are some missing complementary tags with no conflicts, can be merged
+ return 1;
+}
+
+
+static HeaderLine *sam_header_line_clone(const HeaderLine *hline)
+{
+ list_t *tags;
+ HeaderLine *out = malloc(sizeof(HeaderLine));
+ out->type[0] = hline->type[0];
+ out->type[1] = hline->type[1];
+ out->tags = NULL;
+
+ tags = hline->tags;
+ while (tags)
+ {
+ HeaderTag *old = tags->data;
+
+ HeaderTag *new = malloc(sizeof(HeaderTag));
+ new->key[0] = old->key[0];
+ new->key[1] = old->key[1];
+ new->value = strdup(old->value);
+ out->tags = list_append(out->tags, new);
+
+ tags = tags->next;
+ }
+ return out;
+}
+
+static int sam_header_line_merge_with(HeaderLine *out_hline, const HeaderLine *tmpl_hline)
+{
+ list_t *tmpl_tags;
+
+ if ( out_hline->type[0]!=tmpl_hline->type[0] || out_hline->type[1]!=tmpl_hline->type[1] )
+ return 0;
+
+ tmpl_tags = tmpl_hline->tags;
+ while (tmpl_tags)
+ {
+ HeaderTag *tmpl_tag = tmpl_tags->data;
+ HeaderTag *out_tag = header_line_has_tag(out_hline, tmpl_tag->key);
+ if ( !out_tag )
+ {
+ HeaderTag *tag = malloc(sizeof(HeaderTag));
+ tag->key[0] = tmpl_tag->key[0];
+ tag->key[1] = tmpl_tag->key[1];
+ tag->value = strdup(tmpl_tag->value);
+ out_hline->tags = list_append(out_hline->tags,tag);
+ }
+ tmpl_tags = tmpl_tags->next;
+ }
+ return 1;
+}
+
+
+static HeaderLine *sam_header_line_parse(const char *headerLine)
+{
+ HeaderLine *hline;
+ HeaderTag *tag;
+ const char *from, *to;
+ from = headerLine;
+
+ if ( *from != '@' ) {
+ debug("[sam_header_line_parse] expected '@', got [%s]\n", headerLine);
+ return 0;
+ }
+ to = ++from;
+
+ while (*to && *to!='\t') to++;
+ if ( to-from != 2 ) {
+ debug("[sam_header_line_parse] expected '@XY', got [%s]\nHint: The header tags must be tab-separated.\n", headerLine);
+ return 0;
+ }
+
+ hline = malloc(sizeof(HeaderLine));
+ hline->type[0] = from[0];
+ hline->type[1] = from[1];
+ hline->tags = NULL;
+
+ int itype = tag_exists(hline->type, types);
+
+ from = to;
+ while (*to && *to=='\t') to++;
+ if ( to-from != 1 ) {
+ debug("[sam_header_line_parse] multiple tabs on line [%s] (%d)\n", headerLine,(int)(to-from));
+ return 0;
+ }
+ from = to;
+ while (*from)
+ {
+ while (*to && *to!='\t') to++;
+
+ if ( !required_tags[itype] && !optional_tags[itype] )
+ {
+ // CO is a special case, it can contain anything, including tabs
+ if ( *to ) { to++; continue; }
+ tag = new_tag(" ",from,to-1);
+ }
+ else
+ tag = new_tag(from,from+3,to-1);
+
+ if ( header_line_has_tag(hline,tag->key) )
+ debug("The tag '%c%c' present (at least) twice on line [%s]\n", tag->key[0],tag->key[1], headerLine);
+ hline->tags = list_append(hline->tags, tag);
+
+ from = to;
+ while (*to && *to=='\t') to++;
+ if ( *to && to-from != 1 ) {
+ debug("[sam_header_line_parse] multiple tabs on line [%s] (%d)\n", headerLine,(int)(to-from));
+ return 0;
+ }
+
+ from = to;
+ }
+ return hline;
+}
+
+
+// Must be of an existing type, all tags must be recognised and all required tags must be present
+static int sam_header_line_validate(HeaderLine *hline)
+{
+ list_t *tags;
+ HeaderTag *tag;
+ int itype, itag;
+
+ // Is the type correct?
+ itype = tag_exists(hline->type, types);
+ if ( itype==-1 )
+ {
+ debug("The type [%c%c] not recognised.\n", hline->type[0],hline->type[1]);
+ return 0;
+ }
+
+ // Has all required tags?
+ itag = 0;
+ while ( required_tags[itype] && required_tags[itype][itag] )
+ {
+ if ( !header_line_has_tag(hline,required_tags[itype][itag]) )
+ {
+ debug("The tag [%c%c] required for [%c%c] not present.\n", required_tags[itype][itag][0],required_tags[itype][itag][1],
+ hline->type[0],hline->type[1]);
+ return 0;
+ }
+ itag++;
+ }
+
+ // Are all tags recognised?
+ tags = hline->tags;
+ while ( tags )
+ {
+ tag = tags->data;
+ if ( !tag_exists(tag->key,required_tags[itype]) && !tag_exists(tag->key,optional_tags[itype]) )
+ {
+ debug("Unknown tag [%c%c] for [%c%c].\n", tag->key[0],tag->key[1], hline->type[0],hline->type[1]);
+ return 0;
+ }
+ tags = tags->next;
+ }
+
+ return 1;
+}
+
+
+static void print_header_line(FILE *fp, HeaderLine *hline)
+{
+ list_t *tags = hline->tags;
+ HeaderTag *tag;
+
+ fprintf(fp, "@%c%c", hline->type[0],hline->type[1]);
+ while (tags)
+ {
+ tag = tags->data;
+
+ fprintf(fp, "\t");
+ if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
+ fprintf(fp, "%c%c:", tag->key[0],tag->key[1]);
+ fprintf(fp, "%s", tag->value);
+
+ tags = tags->next;
+ }
+ fprintf(fp,"\n");
+}
+
+
+static void sam_header_line_free(HeaderLine *hline)
+{
+ list_t *tags = hline->tags;
+ while (tags)
+ {
+ HeaderTag *tag = tags->data;
+ free(tag->value);
+ free(tag);
+ tags = tags->next;
+ }
+ list_free(hline->tags);
+ free(hline);
+}
+
+void sam_header_free(void *_header)
+{
+ HeaderDict *header = (HeaderDict*)_header;
+ list_t *hlines = header;
+ while (hlines)
+ {
+ sam_header_line_free(hlines->data);
+ hlines = hlines->next;
+ }
+ list_free(header);
+}
+
+HeaderDict *sam_header_clone(const HeaderDict *dict)
+{
+ HeaderDict *out = NULL;
+ while (dict)
+ {
+ HeaderLine *hline = dict->data;
+ out = list_append(out, sam_header_line_clone(hline));
+ dict = dict->next;
+ }
+ return out;
+}
+
+// Returns a newly allocated string
+char *sam_header_write(const void *_header)
+{
+ const HeaderDict *header = (const HeaderDict*)_header;
+ char *out = NULL;
+ int len=0, nout=0;
+ const list_t *hlines;
+
+ // Calculate the length of the string to allocate
+ hlines = header;
+ while (hlines)
+ {
+ len += 4; // @XY and \n
+
+ HeaderLine *hline = hlines->data;
+ list_t *tags = hline->tags;
+ while (tags)
+ {
+ HeaderTag *tag = tags->data;
+ len += strlen(tag->value) + 1; // \t
+ if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
+ len += strlen(tag->value) + 3; // XY:
+ tags = tags->next;
+ }
+ hlines = hlines->next;
+ }
+
+ nout = 0;
+ out = malloc(len+1);
+ hlines = header;
+ while (hlines)
+ {
+ HeaderLine *hline = hlines->data;
+
+ nout += sprintf(out+nout,"@%c%c",hline->type[0],hline->type[1]);
+
+ list_t *tags = hline->tags;
+ while (tags)
+ {
+ HeaderTag *tag = tags->data;
+ nout += sprintf(out+nout,"\t");
+ if ( tag->key[0]!=' ' || tag->key[1]!=' ' )
+ nout += sprintf(out+nout,"%c%c:", tag->key[0],tag->key[1]);
+ nout += sprintf(out+nout,"%s", tag->value);
+ tags = tags->next;
+ }
+ hlines = hlines->next;
+ nout += sprintf(out+nout,"\n");
+ }
+ out[len] = 0;
+ return out;
+}
+
+void *sam_header_parse2(const char *headerText)
+{
+ list_t *hlines = NULL;
+ HeaderLine *hline;
+ const char *text;
+ char *buf=NULL;
+ size_t nbuf = 0;
+ int tovalidate = 0;
+
+ if ( !headerText )
+ return 0;
+
+ text = headerText;
+ while ( (text=nextline(&buf, &nbuf, text)) )
+ {
+ hline = sam_header_line_parse(buf);
+ if ( hline && (!tovalidate || sam_header_line_validate(hline)) )
+ // With too many (~250,000) reference sequences the header parsing was too slow with list_append.
+ hlines = list_append_to_end(hlines, hline);
+ else
+ {
+ if (hline) sam_header_line_free(hline);
+ sam_header_free(hlines);
+ if ( buf ) free(buf);
+ return NULL;
+ }
+ }
+ if ( buf ) free(buf);
+
+ return hlines;
+}
+
+void *sam_header2tbl(const void *_dict, char type[2], char key_tag[2], char value_tag[2])
+{
+ const HeaderDict *dict = (const HeaderDict*)_dict;
+ const list_t *l = dict;
+ khash_t(str) *tbl = kh_init(str);
+ khiter_t k;
+ int ret;
+
+ if (_dict == 0) return tbl; // return an empty (not null) hash table
+ while (l)
+ {
+ HeaderLine *hline = l->data;
+ if ( hline->type[0]!=type[0] || hline->type[1]!=type[1] )
+ {
+ l = l->next;
+ continue;
+ }
+
+ HeaderTag *key, *value;
+ key = header_line_has_tag(hline,key_tag);
+ value = header_line_has_tag(hline,value_tag);
+ if ( !key || !value )
+ {
+ l = l->next;
+ continue;
+ }
+
+ k = kh_get(str, tbl, key->value);
+ if ( k != kh_end(tbl) )
+ debug("[sam_header_lookup_table] They key %s not unique.\n", key->value);
+ k = kh_put(str, tbl, key->value, &ret);
+ kh_value(tbl, k) = value->value;
+
+ l = l->next;
+ }
+ return tbl;
+}
+
+char **sam_header2list(const void *_dict, char type[2], char key_tag[2], int *_n)
+{
+ const HeaderDict *dict = (const HeaderDict*)_dict;
+ const list_t *l = dict;
+ int max, n;
+ char **ret;
+
+ ret = 0; *_n = max = n = 0;
+ while (l)
+ {
+ HeaderLine *hline = l->data;
+ if ( hline->type[0]!=type[0] || hline->type[1]!=type[1] )
+ {
+ l = l->next;
+ continue;
+ }
+
+ HeaderTag *key;
+ key = header_line_has_tag(hline,key_tag);
+ if ( !key )
+ {
+ l = l->next;
+ continue;
+ }
+
+ if (n == max) {
+ max = max? max<<1 : 4;
+ ret = realloc(ret, max * sizeof(void*));
+ }
+ ret[n++] = key->value;
+
+ l = l->next;
+ }
+ *_n = n;
+ return ret;
+}
+
+const char *sam_tbl_get(void *h, const char *key)
+{
+ khash_t(str) *tbl = (khash_t(str)*)h;
+ khint_t k;
+ k = kh_get(str, tbl, key);
+ return k == kh_end(tbl)? 0 : kh_val(tbl, k);
+}
+
+int sam_tbl_size(void *h)
+{
+ khash_t(str) *tbl = (khash_t(str)*)h;
+ return h? kh_size(tbl) : 0;
+}
+
+void sam_tbl_destroy(void *h)
+{
+ khash_t(str) *tbl = (khash_t(str)*)h;
+ kh_destroy(str, tbl);
+}
+
+void *sam_header_merge(int n, const void **_dicts)
+{
+ const HeaderDict **dicts = (const HeaderDict**)_dicts;
+ HeaderDict *out_dict;
+ int idict, status;
+
+ if ( n<2 ) return NULL;
+
+ out_dict = sam_header_clone(dicts[0]);
+
+ for (idict=1; idict<n; idict++)
+ {
+ const list_t *tmpl_hlines = dicts[idict];
+
+ while ( tmpl_hlines )
+ {
+ list_t *out_hlines = out_dict;
+ int inserted = 0;
+ while ( out_hlines )
+ {
+ status = sam_header_compare_lines(tmpl_hlines->data, out_hlines->data);
+ if ( status==0 )
+ {
+ out_hlines = out_hlines->next;
+ continue;
+ }
+
+ if ( status==2 )
+ {
+ print_header_line(pysamerr,tmpl_hlines->data);
+ print_header_line(pysamerr,out_hlines->data);
+ debug("Conflicting lines, cannot merge the headers.\n");
+ return 0;
+ }
+ if ( status==3 )
+ sam_header_line_merge_with(out_hlines->data, tmpl_hlines->data);
+
+ inserted = 1;
+ break;
+ }
+ if ( !inserted )
+ out_dict = list_append(out_dict, sam_header_line_clone(tmpl_hlines->data));
+
+ tmpl_hlines = tmpl_hlines->next;
+ }
+ }
+
+ return out_dict;
+}
+
+
+++ /dev/null
-#include <stdlib.h>
-#include <string.h>
-#include <stdio.h>
-#include <unistd.h>
-#include <math.h>
-#include "sam_header.h"
-#include "sam.h"
-#include "faidx.h"
-#include "khash.h"
-KHASH_SET_INIT_STR(rg)
-
-typedef khash_t(rg) *rghash_t;
-
-rghash_t g_rghash = 0;
-static int g_min_mapQ = 0, g_flag_on = 0, g_flag_off = 0;
-static char *g_library, *g_rg;
-static int g_sol2sanger_tbl[128];
-
-static void sol2sanger(bam1_t *b)
-{
- int l;
- uint8_t *qual = bam1_qual(b);
- if (g_sol2sanger_tbl[30] == 0) {
- for (l = 0; l != 128; ++l) {
- g_sol2sanger_tbl[l] = (int)(10.0 * log(1.0 + pow(10.0, (l - 64 + 33) / 10.0)) / log(10.0) + .499);
- if (g_sol2sanger_tbl[l] >= 93) g_sol2sanger_tbl[l] = 93;
- }
- }
- for (l = 0; l < b->core.l_qseq; ++l) {
- int q = qual[l];
- if (q > 127) q = 127;
- qual[l] = g_sol2sanger_tbl[q];
- }
-}
-
-static inline int __g_skip_aln(const bam_header_t *h, const bam1_t *b)
-{
- if (b->core.qual < g_min_mapQ || ((b->core.flag & g_flag_on) != g_flag_on) || (b->core.flag & g_flag_off))
- return 1;
- if (g_rg || g_rghash) {
- uint8_t *s = bam_aux_get(b, "RG");
- if (s) {
- if (g_rg) return (strcmp(g_rg, (char*)(s + 1)) == 0)? 0 : 1;
- if (g_rghash) {
- khint_t k = kh_get(rg, g_rghash, (char*)(s + 1));
- return (k != kh_end(g_rghash))? 0 : 1;
- }
- }
- }
- if (g_library) {
- const char *p = bam_get_library((bam_header_t*)h, b);
- return (p && strcmp(p, g_library) == 0)? 0 : 1;
- }
- return 0;
-}
-
-// callback function for bam_fetch()
-static int view_func(const bam1_t *b, void *data)
-{
- if (!__g_skip_aln(((samfile_t*)data)->header, b))
- samwrite((samfile_t*)data, b);
- return 0;
-}
-
-static int usage(int is_long_help);
-
-int main_samview(int argc, char *argv[])
-{
- int c, is_header = 0, is_header_only = 0, is_bamin = 1, ret = 0, is_uncompressed = 0, is_bamout = 0, slx2sngr = 0;
- int of_type = BAM_OFDEC, is_long_help = 0;
- samfile_t *in = 0, *out = 0;
- char in_mode[5], out_mode[5], *fn_out = 0, *fn_list = 0, *fn_ref = 0, *fn_rg = 0;
-
- /* parse command-line options */
- strcpy(in_mode, "r"); strcpy(out_mode, "w");
- while ((c = getopt(argc, argv, "Sbt:hHo:q:f:F:ul:r:xX?T:CR:")) >= 0) {
- switch (c) {
- case 'C': slx2sngr = 1; break;
- case 'S': is_bamin = 0; break;
- case 'b': is_bamout = 1; break;
- case 't': fn_list = strdup(optarg); is_bamin = 0; break;
- case 'h': is_header = 1; break;
- case 'H': is_header_only = 1; break;
- case 'o': fn_out = strdup(optarg); break;
- case 'f': g_flag_on = strtol(optarg, 0, 0); break;
- case 'F': g_flag_off = strtol(optarg, 0, 0); break;
- case 'q': g_min_mapQ = atoi(optarg); break;
- case 'u': is_uncompressed = 1; break;
- case 'l': g_library = strdup(optarg); break;
- case 'r': g_rg = strdup(optarg); break;
- case 'R': fn_rg = strdup(optarg); break;
- case 'x': of_type = BAM_OFHEX; break;
- case 'X': of_type = BAM_OFSTR; break;
- case '?': is_long_help = 1; break;
- case 'T': fn_ref = strdup(optarg); is_bamin = 0; break;
- default: return usage(is_long_help);
- }
- }
- if (is_uncompressed) is_bamout = 1;
- if (is_header_only) is_header = 1;
- if (is_bamout) strcat(out_mode, "b");
- else {
- if (of_type == BAM_OFHEX) strcat(out_mode, "x");
- else if (of_type == BAM_OFSTR) strcat(out_mode, "X");
- }
- if (is_bamin) strcat(in_mode, "b");
- if (is_header) strcat(out_mode, "h");
- if (is_uncompressed) strcat(out_mode, "u");
- if (argc == optind) return usage(is_long_help); // potential memory leak...
-
- // read the list of read groups
- if (fn_rg) {
- FILE *fp_rg;
- char buf[1024];
- int ret;
- g_rghash = kh_init(rg);
- fp_rg = fopen(fn_rg, "r");
- while (!feof(fp_rg) && fscanf(fp_rg, "%s", buf) > 0) // this is not a good style, but bear me...
- kh_put(rg, g_rghash, strdup(buf), &ret); // we'd better check duplicates...
- fclose(fp_rg);
- }
-
- // generate the fn_list if necessary
- if (fn_list == 0 && fn_ref) fn_list = samfaipath(fn_ref);
- // open file handlers
- if ((in = samopen(argv[optind], in_mode, fn_list)) == 0) {
- fprintf(stderr, "[main_samview] fail to open file for reading.\n");
- goto view_end;
- }
- if (in->header == 0) {
- fprintf(stderr, "[main_samview] fail to read the header.\n");
- goto view_end;
- }
- if ((out = samopen(fn_out? fn_out : "-", out_mode, in->header)) == 0) {
- fprintf(stderr, "[main_samview] fail to open file for writing.\n");
- goto view_end;
- }
- if (is_header_only) goto view_end; // no need to print alignments
-
- if (argc == optind + 1) { // convert/print the entire file
- bam1_t *b = bam_init1();
- int r;
- while ((r = samread(in, b)) >= 0) { // read one alignment from `in'
- if (!__g_skip_aln(in->header, b)) {
- if (slx2sngr) sol2sanger(b);
- samwrite(out, b); // write the alignment to `out'
- }
- }
- if (r < -1) fprintf(stderr, "[main_samview] truncated file.\n");
- bam_destroy1(b);
- } else { // retrieve alignments in specified regions
- int i;
- bam_index_t *idx = 0;
- if (is_bamin) idx = bam_index_load(argv[optind]); // load BAM index
- if (idx == 0) { // index is unavailable
- fprintf(stderr, "[main_samview] random alignment retrieval only works for indexed BAM files.\n");
- ret = 1;
- goto view_end;
- }
- for (i = optind + 1; i < argc; ++i) {
- int tid, beg, end;
- bam_parse_region(in->header, argv[i], &tid, &beg, &end); // parse a region in the format like `chr2:100-200'
- if (tid < 0) { // reference name is not found
- fprintf(stderr, "[main_samview] fail to get the reference name. Continue anyway.\n");
- continue;
- }
- bam_fetch(in->x.bam, idx, tid, beg, end, out, view_func); // fetch alignments
- }
- bam_index_destroy(idx); // destroy the BAM index
- }
-
-view_end:
- // close files, free and return
- free(fn_list); free(fn_ref); free(fn_out); free(g_library); free(g_rg); free(fn_rg);
- if (g_rghash) {
- khint_t k;
- for (k = 0; k < kh_end(g_rghash); ++k)
- if (kh_exist(g_rghash, k)) free((char*)kh_key(g_rghash, k));
- kh_destroy(rg, g_rghash);
- }
- samclose(in);
- samclose(out);
- return ret;
-}
-
-static int usage(int is_long_help)
-{
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: samtools view [options] <in.bam>|<in.sam> [region1 [...]]\n\n");
- fprintf(stderr, "Options: -b output BAM\n");
- fprintf(stderr, " -h print header for the SAM output\n");
- fprintf(stderr, " -H print header only (no alignments)\n");
- fprintf(stderr, " -S input is SAM\n");
- fprintf(stderr, " -u uncompressed BAM output (force -b)\n");
- fprintf(stderr, " -x output FLAG in HEX (samtools-C specific)\n");
- fprintf(stderr, " -X output FLAG in string (samtools-C specific)\n");
- fprintf(stderr, " -t FILE list of reference names and lengths (force -S) [null]\n");
- fprintf(stderr, " -T FILE reference sequence file (force -S) [null]\n");
- fprintf(stderr, " -o FILE output file name [stdout]\n");
- fprintf(stderr, " -R FILE list of read groups to be outputted [null]\n");
- fprintf(stderr, " -f INT required flag, 0 for unset [0]\n");
- fprintf(stderr, " -F INT filtering flag, 0 for unset [0]\n");
- fprintf(stderr, " -q INT minimum mapping quality [0]\n");
- fprintf(stderr, " -l STR only output reads in library STR [null]\n");
- fprintf(stderr, " -r STR only output reads in read group STR [null]\n");
- fprintf(stderr, " -? longer help\n");
- fprintf(stderr, "\n");
- if (is_long_help)
- fprintf(stderr, "Notes:\n\
-\n\
- 1. By default, this command assumes the file on the command line is in\n\
- the BAM format and it prints the alignments in SAM. If `-t' is\n\
- applied, the input file is assumed to be in the SAM format. The\n\
- file supplied with `-t' is SPACE/TAB delimited with the first two\n\
- fields of each line consisting of the reference name and the\n\
- corresponding sequence length. The `.fai' file generated by `faidx'\n\
- can be used here. This file may be empty if reads are unaligned.\n\
-\n\
- 2. SAM->BAM conversion: `samtools view -bT ref.fa in.sam.gz'.\n\
-\n\
- 3. BAM->SAM conversion: `samtools view in.bam'.\n\
-\n\
- 4. A region should be presented in one of the following formats:\n\
- `chr1', `chr2:1,000' and `chr3:1000-2,000'. When a region is\n\
- specified, the input alignment file must be an indexed BAM file.\n\
-\n\
- 5. Option `-u' is preferred over `-b' when the output is piped to\n\
- another samtools command.\n\
-\n\
- 6. In a string FLAG, each character represents one bit with\n\
- p=0x1 (paired), P=0x2 (properly paired), u=0x4 (unmapped),\n\
- U=0x8 (mate unmapped), r=0x10 (reverse), R=0x20 (mate reverse)\n\
- 1=0x40 (first), 2=0x80 (second), s=0x100 (not primary), \n\
- f=0x200 (failure) and d=0x400 (duplicate). Note that `-x' and\n\
- `-X' are samtools-C specific. Picard and older samtools do not\n\
- support HEX or string flags.\n\
-\n");
- return 1;
-}
-
-int main_import(int argc, char *argv[])
-{
- int argc2, ret;
- char **argv2;
- if (argc != 4) {
- fprintf(stderr, "Usage: bamtk import <in.ref_list> <in.sam> <out.bam>\n");
- return 1;
- }
- argc2 = 6;
- argv2 = calloc(6, sizeof(char*));
- argv2[0] = "import", argv2[1] = "-o", argv2[2] = argv[3], argv2[3] = "-bt", argv2[4] = argv[1], argv2[5] = argv[2];
- ret = main_samview(argc2, argv2);
- free(argv2);
- return ret;
-}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <string.h>
+#include <stdio.h>
+#include <unistd.h>
+#include <math.h>
+#include "sam_header.h"
+#include "sam.h"
+#include "faidx.h"
+#include "kstring.h"
+#include "khash.h"
+KHASH_SET_INIT_STR(rg)
+
+// When counting records instead of printing them,
+// data passed to the bam_fetch callback is encapsulated in this struct.
+typedef struct {
+ bam_header_t *header;
+ int *count;
+} count_func_data_t;
+
+typedef khash_t(rg) *rghash_t;
+
+static rghash_t g_rghash = 0;
+static int g_min_mapQ = 0, g_flag_on = 0, g_flag_off = 0;
+static char *g_library, *g_rg;
+static int g_sol2sanger_tbl[128];
+static void *g_bed;
+
+void *bed_read(const char *fn);
+void bed_destroy(void *_h);
+int bed_overlap(const void *_h, const char *chr, int beg, int end);
+
+static void sol2sanger(bam1_t *b)
+{
+ int l;
+ uint8_t *qual = bam1_qual(b);
+ if (g_sol2sanger_tbl[30] == 0) {
+ for (l = 0; l != 128; ++l) {
+ g_sol2sanger_tbl[l] = (int)(10.0 * log(1.0 + pow(10.0, (l - 64 + 33) / 10.0)) / log(10.0) + .499);
+ if (g_sol2sanger_tbl[l] >= 93) g_sol2sanger_tbl[l] = 93;
+ }
+ }
+ for (l = 0; l < b->core.l_qseq; ++l) {
+ int q = qual[l];
+ if (q > 127) q = 127;
+ qual[l] = g_sol2sanger_tbl[q];
+ }
+}
+
+static inline int __g_skip_aln(const bam_header_t *h, const bam1_t *b)
+{
+ if (b->core.qual < g_min_mapQ || ((b->core.flag & g_flag_on) != g_flag_on) || (b->core.flag & g_flag_off))
+ return 1;
+ if (g_bed && b->core.tid >= 0 && !bed_overlap(g_bed, h->target_name[b->core.tid], b->core.pos, bam_calend(&b->core, bam1_cigar(b))))
+ return 1;
+ if (g_rg || g_rghash) {
+ uint8_t *s = bam_aux_get(b, "RG");
+ if (s) {
+ if (g_rg) return (strcmp(g_rg, (char*)(s + 1)) == 0)? 0 : 1;
+ if (g_rghash) {
+ khint_t k = kh_get(rg, g_rghash, (char*)(s + 1));
+ return (k != kh_end(g_rghash))? 0 : 1;
+ }
+ }
+ }
+ if (g_library) {
+ const char *p = bam_get_library((bam_header_t*)h, b);
+ return (p && strcmp(p, g_library) == 0)? 0 : 1;
+ }
+ return 0;
+}
+
+static char *drop_rg(char *hdtxt, rghash_t h, int *len)
+{
+ char *p = hdtxt, *q, *r, *s;
+ kstring_t str;
+ memset(&str, 0, sizeof(kstring_t));
+ while (1) {
+ int toprint = 0;
+ q = strchr(p, '\n');
+ if (q == 0) q = p + strlen(p);
+ if (q - p < 3) break; // the line is too short; then stop
+ if (strncmp(p, "@RG\t", 4) == 0) {
+ int c;
+ khint_t k;
+ if ((r = strstr(p, "\tID:")) != 0) {
+ r += 4;
+ for (s = r; *s != '\0' && *s != '\n' && *s != '\t'; ++s);
+ c = *s; *s = '\0';
+ k = kh_get(rg, h, r);
+ *s = c;
+ if (k != kh_end(h)) toprint = 1;
+ }
+ } else toprint = 1;
+ if (toprint) {
+ kputsn(p, q - p, &str); kputc('\n', &str);
+ }
+ p = q + 1;
+ }
+ *len = str.l;
+ return str.s;
+}
+
+// callback function for bam_fetch() that prints nonskipped records
+static int view_func(const bam1_t *b, void *data)
+{
+ if (!__g_skip_aln(((samfile_t*)data)->header, b))
+ samwrite((samfile_t*)data, b);
+ return 0;
+}
+
+// callback function for bam_fetch() that counts nonskipped records
+static int count_func(const bam1_t *b, void *data)
+{
+ if (!__g_skip_aln(((count_func_data_t*)data)->header, b)) {
+ (*((count_func_data_t*)data)->count)++;
+ }
+ return 0;
+}
+
+static int usage(int is_long_help);
+
+int main_samview(int argc, char *argv[])
+{
+ int c, is_header = 0, is_header_only = 0, is_bamin = 1, ret = 0, compress_level = -1, is_bamout = 0, slx2sngr = 0, is_count = 0;
+ int of_type = BAM_OFDEC, is_long_help = 0;
+ int count = 0;
+ samfile_t *in = 0, *out = 0;
+ char in_mode[5], out_mode[5], *fn_out = 0, *fn_list = 0, *fn_ref = 0, *fn_rg = 0;
+
+ /* parse command-line options */
+ strcpy(in_mode, "r"); strcpy(out_mode, "w");
+ while ((c = getopt(argc, argv, "Sbct:h1Ho:q:f:F:ul:r:xX?T:CR:L:")) >= 0) {
+ switch (c) {
+ case 'c': is_count = 1; break;
+ case 'C': slx2sngr = 1; break;
+ case 'S': is_bamin = 0; break;
+ case 'b': is_bamout = 1; break;
+ case 't': fn_list = strdup(optarg); is_bamin = 0; break;
+ case 'h': is_header = 1; break;
+ case 'H': is_header_only = 1; break;
+ case 'o': fn_out = strdup(optarg); break;
+ case 'f': g_flag_on = strtol(optarg, 0, 0); break;
+ case 'F': g_flag_off = strtol(optarg, 0, 0); break;
+ case 'q': g_min_mapQ = atoi(optarg); break;
+ case 'u': compress_level = 0; break;
+ case '1': compress_level = 1; break;
+ case 'l': g_library = strdup(optarg); break;
+ case 'L': g_bed = bed_read(optarg); break;
+ case 'r': g_rg = strdup(optarg); break;
+ case 'R': fn_rg = strdup(optarg); break;
+ case 'x': of_type = BAM_OFHEX; break;
+ case 'X': of_type = BAM_OFSTR; break;
+ case '?': is_long_help = 1; break;
+ case 'T': fn_ref = strdup(optarg); is_bamin = 0; break;
+ default: return usage(is_long_help);
+ }
+ }
+ if (compress_level >= 0) is_bamout = 1;
+ if (is_header_only) is_header = 1;
+ if (is_bamout) strcat(out_mode, "b");
+ else {
+ if (of_type == BAM_OFHEX) strcat(out_mode, "x");
+ else if (of_type == BAM_OFSTR) strcat(out_mode, "X");
+ }
+ if (is_bamin) strcat(in_mode, "b");
+ if (is_header) strcat(out_mode, "h");
+ if (compress_level >= 0) {
+ char tmp[2];
+ tmp[0] = compress_level + '0'; tmp[1] = '\0';
+ strcat(out_mode, tmp);
+ }
+ if (argc == optind) return usage(is_long_help); // potential memory leak...
+
+ // read the list of read groups
+ if (fn_rg) {
+ FILE *fp_rg;
+ char buf[1024];
+ int ret;
+ g_rghash = kh_init(rg);
+ fp_rg = fopen(fn_rg, "r");
+ while (!feof(fp_rg) && fscanf(fp_rg, "%s", buf) > 0) // this is not a good style, but bear me...
+ kh_put(rg, g_rghash, strdup(buf), &ret); // we'd better check duplicates...
+ fclose(fp_rg);
+ }
+
+ // generate the fn_list if necessary
+ if (fn_list == 0 && fn_ref) fn_list = samfaipath(fn_ref);
+ // open file handlers
+ if ((in = samopen(argv[optind], in_mode, fn_list)) == 0) {
+ fprintf(pysamerr, "[main_samview] fail to open \"%s\" for reading.\n", argv[optind]);
+ ret = 1;
+ goto view_end;
+ }
+ if (in->header == 0) {
+ fprintf(pysamerr, "[main_samview] fail to read the header from \"%s\".\n", argv[optind]);
+ ret = 1;
+ goto view_end;
+ }
+ if (g_rghash) { // FIXME: I do not know what "bam_header_t::n_text" is for...
+ char *tmp;
+ int l;
+ tmp = drop_rg(in->header->text, g_rghash, &l);
+ free(in->header->text);
+ in->header->text = tmp;
+ in->header->l_text = l;
+ }
+ if (!is_count && (out = samopen(fn_out? fn_out : "-", out_mode, in->header)) == 0) {
+ fprintf(pysamerr, "[main_samview] fail to open \"%s\" for writing.\n", fn_out? fn_out : "standard output");
+ ret = 1;
+ goto view_end;
+ }
+ if (is_header_only) goto view_end; // no need to print alignments
+
+ if (argc == optind + 1) { // convert/print the entire file
+ bam1_t *b = bam_init1();
+ int r;
+ while ((r = samread(in, b)) >= 0) { // read one alignment from `in'
+ if (!__g_skip_aln(in->header, b)) {
+ if (slx2sngr) sol2sanger(b);
+ if (!is_count) samwrite(out, b); // write the alignment to `out'
+ count++;
+ }
+ }
+ if (r < -1) {
+ fprintf(pysamerr, "[main_samview] truncated file.\n");
+ ret = 1;
+ }
+ bam_destroy1(b);
+ } else { // retrieve alignments in specified regions
+ int i;
+ bam_index_t *idx = 0;
+ if (is_bamin) idx = bam_index_load(argv[optind]); // load BAM index
+ if (idx == 0) { // index is unavailable
+ fprintf(pysamerr, "[main_samview] random alignment retrieval only works for indexed BAM files.\n");
+ ret = 1;
+ goto view_end;
+ }
+ for (i = optind + 1; i < argc; ++i) {
+ int tid, beg, end, result;
+ bam_parse_region(in->header, argv[i], &tid, &beg, &end); // parse a region in the format like `chr2:100-200'
+ if (tid < 0) { // reference name is not found
+ fprintf(pysamerr, "[main_samview] region \"%s\" specifies an unknown reference name. Continue anyway.\n", argv[i]);
+ continue;
+ }
+ // fetch alignments
+ if (is_count) {
+ count_func_data_t count_data = { in->header, &count };
+ result = bam_fetch(in->x.bam, idx, tid, beg, end, &count_data, count_func);
+ } else
+ result = bam_fetch(in->x.bam, idx, tid, beg, end, out, view_func);
+ if (result < 0) {
+ fprintf(pysamerr, "[main_samview] retrieval of region \"%s\" failed due to truncated file or corrupt BAM index file\n", argv[i]);
+ ret = 1;
+ break;
+ }
+ }
+ bam_index_destroy(idx); // destroy the BAM index
+ }
+
+view_end:
+ if (is_count && ret == 0) {
+ printf("%d\n", count);
+ }
+ // close files, free and return
+ free(fn_list); free(fn_ref); free(fn_out); free(g_library); free(g_rg); free(fn_rg);
+ if (g_bed) bed_destroy(g_bed);
+ if (g_rghash) {
+ khint_t k;
+ for (k = 0; k < kh_end(g_rghash); ++k)
+ if (kh_exist(g_rghash, k)) free((char*)kh_key(g_rghash, k));
+ kh_destroy(rg, g_rghash);
+ }
+ samclose(in);
+ if (!is_count)
+ samclose(out);
+ return ret;
+}
+
+static int usage(int is_long_help)
+{
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: samtools view [options] <in.bam>|<in.sam> [region1 [...]]\n\n");
+ fprintf(pysamerr, "Options: -b output BAM\n");
+ fprintf(pysamerr, " -h print header for the SAM output\n");
+ fprintf(pysamerr, " -H print header only (no alignments)\n");
+ fprintf(pysamerr, " -S input is SAM\n");
+ fprintf(pysamerr, " -u uncompressed BAM output (force -b)\n");
+ fprintf(pysamerr, " -1 fast compression (force -b)\n");
+ fprintf(pysamerr, " -x output FLAG in HEX (samtools-C specific)\n");
+ fprintf(pysamerr, " -X output FLAG in string (samtools-C specific)\n");
+ fprintf(pysamerr, " -c print only the count of matching records\n");
+ fprintf(pysamerr, " -L FILE output alignments overlapping the input BED FILE [null]\n");
+ fprintf(pysamerr, " -t FILE list of reference names and lengths (force -S) [null]\n");
+ fprintf(pysamerr, " -T FILE reference sequence file (force -S) [null]\n");
+ fprintf(pysamerr, " -o FILE output file name [stdout]\n");
+ fprintf(pysamerr, " -R FILE list of read groups to be outputted [null]\n");
+ fprintf(pysamerr, " -f INT required flag, 0 for unset [0]\n");
+ fprintf(pysamerr, " -F INT filtering flag, 0 for unset [0]\n");
+ fprintf(pysamerr, " -q INT minimum mapping quality [0]\n");
+ fprintf(pysamerr, " -l STR only output reads in library STR [null]\n");
+ fprintf(pysamerr, " -r STR only output reads in read group STR [null]\n");
+ fprintf(pysamerr, " -? longer help\n");
+ fprintf(pysamerr, "\n");
+ if (is_long_help)
+ fprintf(pysamerr, "Notes:\n\
+\n\
+ 1. By default, this command assumes the file on the command line is in\n\
+ the BAM format and it prints the alignments in SAM. If `-t' is\n\
+ applied, the input file is assumed to be in the SAM format. The\n\
+ file supplied with `-t' is SPACE/TAB delimited with the first two\n\
+ fields of each line consisting of the reference name and the\n\
+ corresponding sequence length. The `.fai' file generated by `faidx'\n\
+ can be used here. This file may be empty if reads are unaligned.\n\
+\n\
+ 2. SAM->BAM conversion: `samtools view -bT ref.fa in.sam.gz'.\n\
+\n\
+ 3. BAM->SAM conversion: `samtools view in.bam'.\n\
+\n\
+ 4. A region should be presented in one of the following formats:\n\
+ `chr1', `chr2:1,000' and `chr3:1000-2,000'. When a region is\n\
+ specified, the input alignment file must be an indexed BAM file.\n\
+\n\
+ 5. Option `-u' is preferred over `-b' when the output is piped to\n\
+ another samtools command.\n\
+\n\
+ 6. In a string FLAG, each character represents one bit with\n\
+ p=0x1 (paired), P=0x2 (properly paired), u=0x4 (unmapped),\n\
+ U=0x8 (mate unmapped), r=0x10 (reverse), R=0x20 (mate reverse)\n\
+ 1=0x40 (first), 2=0x80 (second), s=0x100 (not primary), \n\
+ f=0x200 (failure) and d=0x400 (duplicate). Note that `-x' and\n\
+ `-X' are samtools-C specific. Picard and older samtools do not\n\
+ support HEX or string flags.\n\
+\n");
+ return 1;
+}
+
+int main_import(int argc, char *argv[])
+{
+ int argc2, ret;
+ char **argv2;
+ if (argc != 4) {
+ fprintf(pysamerr, "Usage: bamtk import <in.ref_list> <in.sam> <out.bam>\n");
+ return 1;
+ }
+ argc2 = 6;
+ argv2 = calloc(6, sizeof(char*));
+ argv2[0] = "import", argv2[1] = "-o", argv2[2] = argv[3], argv2[3] = "-bt", argv2[4] = argv[1], argv2[5] = argv[2];
+ ret = main_samview(argc2, argv2);
+ free(argv2);
+ return ret;
+}
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <string.h>
+#include "sample.h"
+#include "khash.h"
+KHASH_MAP_INIT_STR(sm, int)
+
+bam_sample_t *bam_smpl_init(void)
+{
+ bam_sample_t *s;
+ s = calloc(1, sizeof(bam_sample_t));
+ s->rg2smid = kh_init(sm);
+ s->sm2id = kh_init(sm);
+ return s;
+}
+
+void bam_smpl_destroy(bam_sample_t *sm)
+{
+ int i;
+ khint_t k;
+ khash_t(sm) *rg2smid = (khash_t(sm)*)sm->rg2smid;
+ if (sm == 0) return;
+ for (i = 0; i < sm->n; ++i) free(sm->smpl[i]);
+ free(sm->smpl);
+ for (k = kh_begin(rg2smid); k != kh_end(rg2smid); ++k)
+ if (kh_exist(rg2smid, k)) free((char*)kh_key(rg2smid, k));
+ kh_destroy(sm, sm->rg2smid);
+ kh_destroy(sm, sm->sm2id);
+ free(sm);
+}
+
+static void add_pair(bam_sample_t *sm, khash_t(sm) *sm2id, const char *key, const char *val)
+{
+ khint_t k_rg, k_sm;
+ int ret;
+ khash_t(sm) *rg2smid = (khash_t(sm)*)sm->rg2smid;
+ k_rg = kh_get(sm, rg2smid, key);
+ if (k_rg != kh_end(rg2smid)) return; // duplicated @RG-ID
+ k_rg = kh_put(sm, rg2smid, strdup(key), &ret);
+ k_sm = kh_get(sm, sm2id, val);
+ if (k_sm == kh_end(sm2id)) { // absent
+ if (sm->n == sm->m) {
+ sm->m = sm->m? sm->m<<1 : 1;
+ sm->smpl = realloc(sm->smpl, sizeof(void*) * sm->m);
+ }
+ sm->smpl[sm->n] = strdup(val);
+ k_sm = kh_put(sm, sm2id, sm->smpl[sm->n], &ret);
+ kh_val(sm2id, k_sm) = sm->n++;
+ }
+ kh_val(rg2smid, k_rg) = kh_val(sm2id, k_sm);
+}
+
+int bam_smpl_add(bam_sample_t *sm, const char *fn, const char *txt)
+{
+ const char *p = txt, *q, *r;
+ kstring_t buf;
+ int n = 0;
+ khash_t(sm) *sm2id = (khash_t(sm)*)sm->sm2id;
+ memset(&buf, 0, sizeof(kstring_t));
+ while ((q = strstr(p, "@RG")) != 0) {
+ p = q + 3;
+ r = q = 0;
+ if ((q = strstr(p, "\tID:")) != 0) q += 4;
+ if ((r = strstr(p, "\tSM:")) != 0) r += 4;
+ if (r && q) {
+ char *u, *v;
+ int oq, or;
+ for (u = (char*)q; *u && *u != '\t' && *u != '\n'; ++u);
+ for (v = (char*)r; *v && *v != '\t' && *v != '\n'; ++v);
+ oq = *u; or = *v; *u = *v = '\0';
+ buf.l = 0; kputs(fn, &buf); kputc('/', &buf); kputs(q, &buf);
+ add_pair(sm, sm2id, buf.s, r);
+ *u = oq; *v = or;
+ } else break;
+ p = q > r? q : r;
+ ++n;
+ }
+ if (n == 0) add_pair(sm, sm2id, fn, fn);
+// add_pair(sm, sm2id, fn, fn);
+ free(buf.s);
+ return 0;
+}
+
+int bam_smpl_rg2smid(const bam_sample_t *sm, const char *fn, const char *rg, kstring_t *str)
+{
+ khint_t k;
+ khash_t(sm) *rg2smid = (khash_t(sm)*)sm->rg2smid;
+ if (rg) {
+ str->l = 0;
+ kputs(fn, str); kputc('/', str); kputs(rg, str);
+ k = kh_get(sm, rg2smid, str->s);
+ } else k = kh_get(sm, rg2smid, fn);
+ return k == kh_end(rg2smid)? -1 : kh_val(rg2smid, k);
+}
--- /dev/null
+#ifndef BAM_SAMPLE_H
+#define BAM_SAMPLE_H
+
+#include "kstring.h"
+
+typedef struct {
+ int n, m;
+ char **smpl;
+ void *rg2smid, *sm2id;
+} bam_sample_t;
+
+bam_sample_t *bam_smpl_init(void);
+int bam_smpl_add(bam_sample_t *sm, const char *abs, const char *txt);
+int bam_smpl_rg2smid(const bam_sample_t *sm, const char *fn, const char *rg, kstring_t *str);
+void bam_smpl_destroy(bam_sample_t *sm);
+
+#endif
--- /dev/null
+/* Public Domain Curses */
+
+/* $Id: curses.h,v 1.295 2008/07/15 17:13:25 wmcbrine Exp $ */
+
+/*----------------------------------------------------------------------*
+ * PDCurses *
+ *----------------------------------------------------------------------*/
+
+#ifndef __PDCURSES__
+#define __PDCURSES__ 1
+
+/*man-start**************************************************************
+
+PDCurses definitions list: (Only define those needed)
+
+ XCURSES True if compiling for X11.
+ PDC_RGB True if you want to use RGB color definitions
+ (Red = 1, Green = 2, Blue = 4) instead of BGR.
+ PDC_WIDE True if building wide-character support.
+ PDC_DLL_BUILD True if building a Win32 DLL.
+ NCURSES_MOUSE_VERSION Use the ncurses mouse API instead
+ of PDCurses' traditional mouse API.
+
+PDCurses portable platform definitions list:
+
+ PDC_BUILD Defines API build version.
+ PDCURSES Enables access to PDCurses-only routines.
+ XOPEN Always true.
+ SYSVcurses True if you are compiling for SYSV portability.
+ BSDcurses True if you are compiling for BSD portability.
+
+**man-end****************************************************************/
+
+#define PDC_BUILD 3401
+#define PDCURSES 1 /* PDCurses-only routines */
+#define XOPEN 1 /* X/Open Curses routines */
+#define SYSVcurses 1 /* System V Curses routines */
+#define BSDcurses 1 /* BSD Curses routines */
+#define CHTYPE_LONG 1 /* size of chtype; long */
+
+/*----------------------------------------------------------------------*/
+
+#include <stdarg.h>
+#include <stddef.h>
+#include <stdio.h> /* Required by X/Open usage below */
+
+#ifdef PDC_WIDE
+# include <wchar.h>
+#endif
+
+#if defined(__cplusplus) || defined(__cplusplus__) || defined(__CPLUSPLUS)
+extern "C"
+{
+# define bool _bool
+#endif
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses Manifest Constants
+ *
+ */
+
+#ifndef FALSE
+# define FALSE 0
+#endif
+#ifndef TRUE
+# define TRUE 1
+#endif
+#ifndef NULL
+# define NULL (void *)0
+#endif
+#ifndef ERR
+# define ERR (-1)
+#endif
+#ifndef OK
+# define OK 0
+#endif
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses Type Declarations
+ *
+ */
+
+typedef unsigned char bool; /* PDCurses Boolean type */
+
+#ifdef CHTYPE_LONG
+# if _LP64
+typedef unsigned int chtype;
+# else
+typedef unsigned long chtype; /* 16-bit attr + 16-bit char */
+# endif
+#else
+typedef unsigned short chtype; /* 8-bit attr + 8-bit char */
+#endif
+
+#ifdef PDC_WIDE
+typedef chtype cchar_t;
+#endif
+
+typedef chtype attr_t;
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses Mouse Interface -- SYSVR4, with extensions
+ *
+ */
+
+typedef struct
+{
+ int x; /* absolute column, 0 based, measured in characters */
+ int y; /* absolute row, 0 based, measured in characters */
+ short button[3]; /* state of each button */
+ int changes; /* flags indicating what has changed with the mouse */
+} MOUSE_STATUS;
+
+#define BUTTON_RELEASED 0x0000
+#define BUTTON_PRESSED 0x0001
+#define BUTTON_CLICKED 0x0002
+#define BUTTON_DOUBLE_CLICKED 0x0003
+#define BUTTON_TRIPLE_CLICKED 0x0004
+#define BUTTON_MOVED 0x0005 /* PDCurses */
+#define WHEEL_SCROLLED 0x0006 /* PDCurses */
+#define BUTTON_ACTION_MASK 0x0007 /* PDCurses */
+
+#define PDC_BUTTON_SHIFT 0x0008 /* PDCurses */
+#define PDC_BUTTON_CONTROL 0x0010 /* PDCurses */
+#define PDC_BUTTON_ALT 0x0020 /* PDCurses */
+#define BUTTON_MODIFIER_MASK 0x0038 /* PDCurses */
+
+#define MOUSE_X_POS (Mouse_status.x)
+#define MOUSE_Y_POS (Mouse_status.y)
+
+/*
+ * Bits associated with the .changes field:
+ * 3 2 1 0
+ * 210987654321098765432109876543210
+ * 1 <- button 1 has changed
+ * 10 <- button 2 has changed
+ * 100 <- button 3 has changed
+ * 1000 <- mouse has moved
+ * 10000 <- mouse position report
+ * 100000 <- mouse wheel up
+ * 1000000 <- mouse wheel down
+ */
+
+#define PDC_MOUSE_MOVED 0x0008
+#define PDC_MOUSE_POSITION 0x0010
+#define PDC_MOUSE_WHEEL_UP 0x0020
+#define PDC_MOUSE_WHEEL_DOWN 0x0040
+
+#define A_BUTTON_CHANGED (Mouse_status.changes & 7)
+#define MOUSE_MOVED (Mouse_status.changes & PDC_MOUSE_MOVED)
+#define MOUSE_POS_REPORT (Mouse_status.changes & PDC_MOUSE_POSITION)
+#define BUTTON_CHANGED(x) (Mouse_status.changes & (1 << ((x) - 1)))
+#define BUTTON_STATUS(x) (Mouse_status.button[(x) - 1])
+#define MOUSE_WHEEL_UP (Mouse_status.changes & PDC_MOUSE_WHEEL_UP)
+#define MOUSE_WHEEL_DOWN (Mouse_status.changes & PDC_MOUSE_WHEEL_DOWN)
+
+/* mouse bit-masks */
+
+#define BUTTON1_RELEASED 0x00000001L
+#define BUTTON1_PRESSED 0x00000002L
+#define BUTTON1_CLICKED 0x00000004L
+#define BUTTON1_DOUBLE_CLICKED 0x00000008L
+#define BUTTON1_TRIPLE_CLICKED 0x00000010L
+#define BUTTON1_MOVED 0x00000010L /* PDCurses */
+
+#define BUTTON2_RELEASED 0x00000020L
+#define BUTTON2_PRESSED 0x00000040L
+#define BUTTON2_CLICKED 0x00000080L
+#define BUTTON2_DOUBLE_CLICKED 0x00000100L
+#define BUTTON2_TRIPLE_CLICKED 0x00000200L
+#define BUTTON2_MOVED 0x00000200L /* PDCurses */
+
+#define BUTTON3_RELEASED 0x00000400L
+#define BUTTON3_PRESSED 0x00000800L
+#define BUTTON3_CLICKED 0x00001000L
+#define BUTTON3_DOUBLE_CLICKED 0x00002000L
+#define BUTTON3_TRIPLE_CLICKED 0x00004000L
+#define BUTTON3_MOVED 0x00004000L /* PDCurses */
+
+/* For the ncurses-compatible functions only, BUTTON4_PRESSED and
+ BUTTON5_PRESSED are returned for mouse scroll wheel up and down;
+ otherwise PDCurses doesn't support buttons 4 and 5 */
+
+#define BUTTON4_RELEASED 0x00008000L
+#define BUTTON4_PRESSED 0x00010000L
+#define BUTTON4_CLICKED 0x00020000L
+#define BUTTON4_DOUBLE_CLICKED 0x00040000L
+#define BUTTON4_TRIPLE_CLICKED 0x00080000L
+
+#define BUTTON5_RELEASED 0x00100000L
+#define BUTTON5_PRESSED 0x00200000L
+#define BUTTON5_CLICKED 0x00400000L
+#define BUTTON5_DOUBLE_CLICKED 0x00800000L
+#define BUTTON5_TRIPLE_CLICKED 0x01000000L
+
+#define MOUSE_WHEEL_SCROLL 0x02000000L /* PDCurses */
+#define BUTTON_MODIFIER_SHIFT 0x04000000L /* PDCurses */
+#define BUTTON_MODIFIER_CONTROL 0x08000000L /* PDCurses */
+#define BUTTON_MODIFIER_ALT 0x10000000L /* PDCurses */
+
+#define ALL_MOUSE_EVENTS 0x1fffffffL
+#define REPORT_MOUSE_POSITION 0x20000000L
+
+/* ncurses mouse interface */
+
+typedef unsigned long mmask_t;
+
+typedef struct
+{
+ short id; /* unused, always 0 */
+ int x, y, z; /* x, y same as MOUSE_STATUS; z unused */
+ mmask_t bstate; /* equivalent to changes + button[], but
+ in the same format as used for mousemask() */
+} MEVENT;
+
+#ifdef NCURSES_MOUSE_VERSION
+# define BUTTON_SHIFT BUTTON_MODIFIER_SHIFT
+# define BUTTON_CONTROL BUTTON_MODIFIER_CONTROL
+# define BUTTON_CTRL BUTTON_MODIFIER_CONTROL
+# define BUTTON_ALT BUTTON_MODIFIER_ALT
+#else
+# define BUTTON_SHIFT PDC_BUTTON_SHIFT
+# define BUTTON_CONTROL PDC_BUTTON_CONTROL
+# define BUTTON_ALT PDC_BUTTON_ALT
+#endif
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses Structure Definitions
+ *
+ */
+
+typedef struct _win /* definition of a window */
+{
+ int _cury; /* current pseudo-cursor */
+ int _curx;
+ int _maxy; /* max window coordinates */
+ int _maxx;
+ int _begy; /* origin on screen */
+ int _begx;
+ int _flags; /* window properties */
+ chtype _attrs; /* standard attributes and colors */
+ chtype _bkgd; /* background, normally blank */
+ bool _clear; /* causes clear at next refresh */
+ bool _leaveit; /* leaves cursor where it is */
+ bool _scroll; /* allows window scrolling */
+ bool _nodelay; /* input character wait flag */
+ bool _immed; /* immediate update flag */
+ bool _sync; /* synchronise window ancestors */
+ bool _use_keypad; /* flags keypad key mode active */
+ chtype **_y; /* pointer to line pointer array */
+ int *_firstch; /* first changed character in line */
+ int *_lastch; /* last changed character in line */
+ int _tmarg; /* top of scrolling region */
+ int _bmarg; /* bottom of scrolling region */
+ int _delayms; /* milliseconds of delay for getch() */
+ int _parx, _pary; /* coords relative to parent (0,0) */
+ struct _win *_parent; /* subwin's pointer to parent win */
+} WINDOW;
+
+/* Avoid using the SCREEN struct directly -- use the corresponding
+ functions if possible. This struct may eventually be made private. */
+
+typedef struct
+{
+ bool alive; /* if initscr() called, and not endwin() */
+ bool autocr; /* if cr -> lf */
+ bool cbreak; /* if terminal unbuffered */
+ bool echo; /* if terminal echo */
+ bool raw_inp; /* raw input mode (v. cooked input) */
+ bool raw_out; /* raw output mode (7 v. 8 bits) */
+ bool audible; /* FALSE if the bell is visual */
+ bool mono; /* TRUE if current screen is mono */
+ bool resized; /* TRUE if TERM has been resized */
+ bool orig_attr; /* TRUE if we have the original colors */
+ short orig_fore; /* original screen foreground color */
+ short orig_back; /* original screen foreground color */
+ int cursrow; /* position of physical cursor */
+ int curscol; /* position of physical cursor */
+ int visibility; /* visibility of cursor */
+ int orig_cursor; /* original cursor size */
+ int lines; /* new value for LINES */
+ int cols; /* new value for COLS */
+ unsigned long _trap_mbe; /* trap these mouse button events */
+ unsigned long _map_mbe_to_key; /* map mouse buttons to slk */
+ int mouse_wait; /* time to wait (in ms) for a
+ button release after a press, in
+ order to count it as a click */
+ int slklines; /* lines in use by slk_init() */
+ WINDOW *slk_winptr; /* window for slk */
+ int linesrippedoff; /* lines ripped off via ripoffline() */
+ int linesrippedoffontop; /* lines ripped off on
+ top via ripoffline() */
+ int delaytenths; /* 1/10ths second to wait block
+ getch() for */
+ bool _preserve; /* TRUE if screen background
+ to be preserved */
+ int _restore; /* specifies if screen background
+ to be restored, and how */
+ bool save_key_modifiers; /* TRUE if each key modifiers saved
+ with each key press */
+ bool return_key_modifiers; /* TRUE if modifier keys are
+ returned as "real" keys */
+ bool key_code; /* TRUE if last key is a special key;
+ used internally by get_wch() */
+#ifdef XCURSES
+ int XcurscrSize; /* size of Xcurscr shared memory block */
+ bool sb_on;
+ int sb_viewport_y;
+ int sb_viewport_x;
+ int sb_total_y;
+ int sb_total_x;
+ int sb_cur_y;
+ int sb_cur_x;
+#endif
+ short line_color; /* color of line attributes - default -1 */
+} SCREEN;
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses External Variables
+ *
+ */
+
+#ifdef PDC_DLL_BUILD
+# ifdef CURSES_LIBRARY
+# define PDCEX __declspec(dllexport) extern
+# else
+# define PDCEX __declspec(dllimport)
+# endif
+#else
+# define PDCEX extern
+#endif
+
+PDCEX int LINES; /* terminal height */
+PDCEX int COLS; /* terminal width */
+PDCEX WINDOW *stdscr; /* the default screen window */
+PDCEX WINDOW *curscr; /* the current screen image */
+PDCEX SCREEN *SP; /* curses variables */
+PDCEX MOUSE_STATUS Mouse_status;
+PDCEX int COLORS;
+PDCEX int COLOR_PAIRS;
+PDCEX int TABSIZE;
+PDCEX chtype acs_map[]; /* alternate character set map */
+PDCEX char ttytype[]; /* terminal name/description */
+
+/*man-start**************************************************************
+
+PDCurses Text Attributes
+========================
+
+Originally, PDCurses used a short (16 bits) for its chtype. To include
+color, a number of things had to be sacrificed from the strict Unix and
+System V support. The main problem was fitting all character attributes
+and color into an unsigned char (all 8 bits!).
+
+Today, PDCurses by default uses a long (32 bits) for its chtype, as in
+System V. The short chtype is still available, by undefining CHTYPE_LONG
+and rebuilding the library.
+
+The following is the structure of a win->_attrs chtype:
+
+short form:
+
+-------------------------------------------------
+|15|14|13|12|11|10| 9| 8| 7| 6| 5| 4| 3| 2| 1| 0|
+-------------------------------------------------
+ color number | attrs | character eg 'a'
+
+The available non-color attributes are bold, reverse and blink. Others
+have no effect. The high order char is an index into an array of
+physical colors (defined in color.c) -- 32 foreground/background color
+pairs (5 bits) plus 3 bits for other attributes.
+
+long form:
+
+----------------------------------------------------------------------------
+|31|30|29|28|27|26|25|24|23|22|21|20|19|18|17|16|15|14|13|12|..| 3| 2| 1| 0|
+----------------------------------------------------------------------------
+ color number | modifiers | character eg 'a'
+
+The available non-color attributes are bold, underline, invisible,
+right-line, left-line, protect, reverse and blink. 256 color pairs (8
+bits), 8 bits for other attributes, and 16 bits for character data.
+
+**man-end****************************************************************/
+
+/*** Video attribute macros ***/
+
+#define A_NORMAL (chtype)0
+
+#ifdef CHTYPE_LONG
+# define A_ALTCHARSET (chtype)0x00010000
+# define A_RIGHTLINE (chtype)0x00020000
+# define A_LEFTLINE (chtype)0x00040000
+# define A_INVIS (chtype)0x00080000
+# define A_UNDERLINE (chtype)0x00100000
+# define A_REVERSE (chtype)0x00200000
+# define A_BLINK (chtype)0x00400000
+# define A_BOLD (chtype)0x00800000
+
+# define A_ATTRIBUTES (chtype)0xffff0000
+# define A_CHARTEXT (chtype)0x0000ffff
+# define A_COLOR (chtype)0xff000000
+
+# define A_ITALIC A_INVIS
+# define A_PROTECT (A_UNDERLINE | A_LEFTLINE | A_RIGHTLINE)
+
+# define PDC_ATTR_SHIFT 19
+# define PDC_COLOR_SHIFT 24
+#else
+# define A_BOLD (chtype)0x0100 /* X/Open */
+# define A_REVERSE (chtype)0x0200 /* X/Open */
+# define A_BLINK (chtype)0x0400 /* X/Open */
+
+# define A_ATTRIBUTES (chtype)0xff00 /* X/Open */
+# define A_CHARTEXT (chtype)0x00ff /* X/Open */
+# define A_COLOR (chtype)0xf800 /* System V */
+
+# define A_ALTCHARSET A_NORMAL /* X/Open */
+# define A_PROTECT A_NORMAL /* X/Open */
+# define A_UNDERLINE A_NORMAL /* X/Open */
+
+# define A_LEFTLINE A_NORMAL
+# define A_RIGHTLINE A_NORMAL
+# define A_ITALIC A_NORMAL
+# define A_INVIS A_NORMAL
+
+# define PDC_ATTR_SHIFT 8
+# define PDC_COLOR_SHIFT 11
+#endif
+
+#define A_STANDOUT (A_REVERSE | A_BOLD) /* X/Open */
+#define A_DIM A_NORMAL
+
+#define CHR_MSK A_CHARTEXT /* Obsolete */
+#define ATR_MSK A_ATTRIBUTES /* Obsolete */
+#define ATR_NRM A_NORMAL /* Obsolete */
+
+/* For use with attr_t -- X/Open says, "these shall be distinct", so
+ this is a non-conforming implementation. */
+
+#define WA_ALTCHARSET A_ALTCHARSET
+#define WA_BLINK A_BLINK
+#define WA_BOLD A_BOLD
+#define WA_DIM A_DIM
+#define WA_INVIS A_INVIS
+#define WA_LEFT A_LEFTLINE
+#define WA_PROTECT A_PROTECT
+#define WA_REVERSE A_REVERSE
+#define WA_RIGHT A_RIGHTLINE
+#define WA_STANDOUT A_STANDOUT
+#define WA_UNDERLINE A_UNDERLINE
+
+#define WA_HORIZONTAL A_NORMAL
+#define WA_LOW A_NORMAL
+#define WA_TOP A_NORMAL
+#define WA_VERTICAL A_NORMAL
+
+/*** Alternate character set macros ***/
+
+/* 'w' = 32-bit chtype; acs_map[] index | A_ALTCHARSET
+ 'n' = 16-bit chtype; it gets the fallback set because no bit is
+ available for A_ALTCHARSET */
+
+#ifdef CHTYPE_LONG
+# define ACS_PICK(w, n) ((chtype)w | A_ALTCHARSET)
+#else
+# define ACS_PICK(w, n) ((chtype)n)
+#endif
+
+/* VT100-compatible symbols -- box chars */
+
+#define ACS_ULCORNER ACS_PICK('l', '+')
+#define ACS_LLCORNER ACS_PICK('m', '+')
+#define ACS_URCORNER ACS_PICK('k', '+')
+#define ACS_LRCORNER ACS_PICK('j', '+')
+#define ACS_RTEE ACS_PICK('u', '+')
+#define ACS_LTEE ACS_PICK('t', '+')
+#define ACS_BTEE ACS_PICK('v', '+')
+#define ACS_TTEE ACS_PICK('w', '+')
+#define ACS_HLINE ACS_PICK('q', '-')
+#define ACS_VLINE ACS_PICK('x', '|')
+#define ACS_PLUS ACS_PICK('n', '+')
+
+/* VT100-compatible symbols -- other */
+
+#define ACS_S1 ACS_PICK('o', '-')
+#define ACS_S9 ACS_PICK('s', '_')
+#define ACS_DIAMOND ACS_PICK('`', '+')
+#define ACS_CKBOARD ACS_PICK('a', ':')
+#define ACS_DEGREE ACS_PICK('f', '\'')
+#define ACS_PLMINUS ACS_PICK('g', '#')
+#define ACS_BULLET ACS_PICK('~', 'o')
+
+/* Teletype 5410v1 symbols -- these are defined in SysV curses, but
+ are not well-supported by most terminals. Stick to VT100 characters
+ for optimum portability. */
+
+#define ACS_LARROW ACS_PICK(',', '<')
+#define ACS_RARROW ACS_PICK('+', '>')
+#define ACS_DARROW ACS_PICK('.', 'v')
+#define ACS_UARROW ACS_PICK('-', '^')
+#define ACS_BOARD ACS_PICK('h', '#')
+#define ACS_LANTERN ACS_PICK('i', '*')
+#define ACS_BLOCK ACS_PICK('0', '#')
+
+/* That goes double for these -- undocumented SysV symbols. Don't use
+ them. */
+
+#define ACS_S3 ACS_PICK('p', '-')
+#define ACS_S7 ACS_PICK('r', '-')
+#define ACS_LEQUAL ACS_PICK('y', '<')
+#define ACS_GEQUAL ACS_PICK('z', '>')
+#define ACS_PI ACS_PICK('{', 'n')
+#define ACS_NEQUAL ACS_PICK('|', '+')
+#define ACS_STERLING ACS_PICK('}', 'L')
+
+/* Box char aliases */
+
+#define ACS_BSSB ACS_ULCORNER
+#define ACS_SSBB ACS_LLCORNER
+#define ACS_BBSS ACS_URCORNER
+#define ACS_SBBS ACS_LRCORNER
+#define ACS_SBSS ACS_RTEE
+#define ACS_SSSB ACS_LTEE
+#define ACS_SSBS ACS_BTEE
+#define ACS_BSSS ACS_TTEE
+#define ACS_BSBS ACS_HLINE
+#define ACS_SBSB ACS_VLINE
+#define ACS_SSSS ACS_PLUS
+
+/* cchar_t aliases */
+
+#ifdef PDC_WIDE
+# define WACS_ULCORNER (&(acs_map['l']))
+# define WACS_LLCORNER (&(acs_map['m']))
+# define WACS_URCORNER (&(acs_map['k']))
+# define WACS_LRCORNER (&(acs_map['j']))
+# define WACS_RTEE (&(acs_map['u']))
+# define WACS_LTEE (&(acs_map['t']))
+# define WACS_BTEE (&(acs_map['v']))
+# define WACS_TTEE (&(acs_map['w']))
+# define WACS_HLINE (&(acs_map['q']))
+# define WACS_VLINE (&(acs_map['x']))
+# define WACS_PLUS (&(acs_map['n']))
+
+# define WACS_S1 (&(acs_map['o']))
+# define WACS_S9 (&(acs_map['s']))
+# define WACS_DIAMOND (&(acs_map['`']))
+# define WACS_CKBOARD (&(acs_map['a']))
+# define WACS_DEGREE (&(acs_map['f']))
+# define WACS_PLMINUS (&(acs_map['g']))
+# define WACS_BULLET (&(acs_map['~']))
+
+# define WACS_LARROW (&(acs_map[',']))
+# define WACS_RARROW (&(acs_map['+']))
+# define WACS_DARROW (&(acs_map['.']))
+# define WACS_UARROW (&(acs_map['-']))
+# define WACS_BOARD (&(acs_map['h']))
+# define WACS_LANTERN (&(acs_map['i']))
+# define WACS_BLOCK (&(acs_map['0']))
+
+# define WACS_S3 (&(acs_map['p']))
+# define WACS_S7 (&(acs_map['r']))
+# define WACS_LEQUAL (&(acs_map['y']))
+# define WACS_GEQUAL (&(acs_map['z']))
+# define WACS_PI (&(acs_map['{']))
+# define WACS_NEQUAL (&(acs_map['|']))
+# define WACS_STERLING (&(acs_map['}']))
+
+# define WACS_BSSB WACS_ULCORNER
+# define WACS_SSBB WACS_LLCORNER
+# define WACS_BBSS WACS_URCORNER
+# define WACS_SBBS WACS_LRCORNER
+# define WACS_SBSS WACS_RTEE
+# define WACS_SSSB WACS_LTEE
+# define WACS_SSBS WACS_BTEE
+# define WACS_BSSS WACS_TTEE
+# define WACS_BSBS WACS_HLINE
+# define WACS_SBSB WACS_VLINE
+# define WACS_SSSS WACS_PLUS
+#endif
+
+/*** Color macros ***/
+
+#define COLOR_BLACK 0
+
+#ifdef PDC_RGB /* RGB */
+# define COLOR_RED 1
+# define COLOR_GREEN 2
+# define COLOR_BLUE 4
+#else /* BGR */
+# define COLOR_BLUE 1
+# define COLOR_GREEN 2
+# define COLOR_RED 4
+#endif
+
+#define COLOR_CYAN (COLOR_BLUE | COLOR_GREEN)
+#define COLOR_MAGENTA (COLOR_RED | COLOR_BLUE)
+#define COLOR_YELLOW (COLOR_RED | COLOR_GREEN)
+
+#define COLOR_WHITE 7
+
+/*----------------------------------------------------------------------
+ *
+ * Function and Keypad Key Definitions.
+ * Many are just for compatibility.
+ *
+ */
+
+#define KEY_CODE_YES 0x100 /* If get_wch() gives a key code */
+
+#define KEY_BREAK 0x101 /* Not on PC KBD */
+#define KEY_DOWN 0x102 /* Down arrow key */
+#define KEY_UP 0x103 /* Up arrow key */
+#define KEY_LEFT 0x104 /* Left arrow key */
+#define KEY_RIGHT 0x105 /* Right arrow key */
+#define KEY_HOME 0x106 /* home key */
+#define KEY_BACKSPACE 0x107 /* not on pc */
+#define KEY_F0 0x108 /* function keys; 64 reserved */
+
+#define KEY_DL 0x148 /* delete line */
+#define KEY_IL 0x149 /* insert line */
+#define KEY_DC 0x14a /* delete character */
+#define KEY_IC 0x14b /* insert char or enter ins mode */
+#define KEY_EIC 0x14c /* exit insert char mode */
+#define KEY_CLEAR 0x14d /* clear screen */
+#define KEY_EOS 0x14e /* clear to end of screen */
+#define KEY_EOL 0x14f /* clear to end of line */
+#define KEY_SF 0x150 /* scroll 1 line forward */
+#define KEY_SR 0x151 /* scroll 1 line back (reverse) */
+#define KEY_NPAGE 0x152 /* next page */
+#define KEY_PPAGE 0x153 /* previous page */
+#define KEY_STAB 0x154 /* set tab */
+#define KEY_CTAB 0x155 /* clear tab */
+#define KEY_CATAB 0x156 /* clear all tabs */
+#define KEY_ENTER 0x157 /* enter or send (unreliable) */
+#define KEY_SRESET 0x158 /* soft/reset (partial/unreliable) */
+#define KEY_RESET 0x159 /* reset/hard reset (unreliable) */
+#define KEY_PRINT 0x15a /* print/copy */
+#define KEY_LL 0x15b /* home down/bottom (lower left) */
+#define KEY_ABORT 0x15c /* abort/terminate key (any) */
+#define KEY_SHELP 0x15d /* short help */
+#define KEY_LHELP 0x15e /* long help */
+#define KEY_BTAB 0x15f /* Back tab key */
+#define KEY_BEG 0x160 /* beg(inning) key */
+#define KEY_CANCEL 0x161 /* cancel key */
+#define KEY_CLOSE 0x162 /* close key */
+#define KEY_COMMAND 0x163 /* cmd (command) key */
+#define KEY_COPY 0x164 /* copy key */
+#define KEY_CREATE 0x165 /* create key */
+#define KEY_END 0x166 /* end key */
+#define KEY_EXIT 0x167 /* exit key */
+#define KEY_FIND 0x168 /* find key */
+#define KEY_HELP 0x169 /* help key */
+#define KEY_MARK 0x16a /* mark key */
+#define KEY_MESSAGE 0x16b /* message key */
+#define KEY_MOVE 0x16c /* move key */
+#define KEY_NEXT 0x16d /* next object key */
+#define KEY_OPEN 0x16e /* open key */
+#define KEY_OPTIONS 0x16f /* options key */
+#define KEY_PREVIOUS 0x170 /* previous object key */
+#define KEY_REDO 0x171 /* redo key */
+#define KEY_REFERENCE 0x172 /* ref(erence) key */
+#define KEY_REFRESH 0x173 /* refresh key */
+#define KEY_REPLACE 0x174 /* replace key */
+#define KEY_RESTART 0x175 /* restart key */
+#define KEY_RESUME 0x176 /* resume key */
+#define KEY_SAVE 0x177 /* save key */
+#define KEY_SBEG 0x178 /* shifted beginning key */
+#define KEY_SCANCEL 0x179 /* shifted cancel key */
+#define KEY_SCOMMAND 0x17a /* shifted command key */
+#define KEY_SCOPY 0x17b /* shifted copy key */
+#define KEY_SCREATE 0x17c /* shifted create key */
+#define KEY_SDC 0x17d /* shifted delete char key */
+#define KEY_SDL 0x17e /* shifted delete line key */
+#define KEY_SELECT 0x17f /* select key */
+#define KEY_SEND 0x180 /* shifted end key */
+#define KEY_SEOL 0x181 /* shifted clear line key */
+#define KEY_SEXIT 0x182 /* shifted exit key */
+#define KEY_SFIND 0x183 /* shifted find key */
+#define KEY_SHOME 0x184 /* shifted home key */
+#define KEY_SIC 0x185 /* shifted input key */
+
+#define KEY_SLEFT 0x187 /* shifted left arrow key */
+#define KEY_SMESSAGE 0x188 /* shifted message key */
+#define KEY_SMOVE 0x189 /* shifted move key */
+#define KEY_SNEXT 0x18a /* shifted next key */
+#define KEY_SOPTIONS 0x18b /* shifted options key */
+#define KEY_SPREVIOUS 0x18c /* shifted prev key */
+#define KEY_SPRINT 0x18d /* shifted print key */
+#define KEY_SREDO 0x18e /* shifted redo key */
+#define KEY_SREPLACE 0x18f /* shifted replace key */
+#define KEY_SRIGHT 0x190 /* shifted right arrow */
+#define KEY_SRSUME 0x191 /* shifted resume key */
+#define KEY_SSAVE 0x192 /* shifted save key */
+#define KEY_SSUSPEND 0x193 /* shifted suspend key */
+#define KEY_SUNDO 0x194 /* shifted undo key */
+#define KEY_SUSPEND 0x195 /* suspend key */
+#define KEY_UNDO 0x196 /* undo key */
+
+/* PDCurses-specific key definitions -- PC only */
+
+#define ALT_0 0x197
+#define ALT_1 0x198
+#define ALT_2 0x199
+#define ALT_3 0x19a
+#define ALT_4 0x19b
+#define ALT_5 0x19c
+#define ALT_6 0x19d
+#define ALT_7 0x19e
+#define ALT_8 0x19f
+#define ALT_9 0x1a0
+#define ALT_A 0x1a1
+#define ALT_B 0x1a2
+#define ALT_C 0x1a3
+#define ALT_D 0x1a4
+#define ALT_E 0x1a5
+#define ALT_F 0x1a6
+#define ALT_G 0x1a7
+#define ALT_H 0x1a8
+#define ALT_I 0x1a9
+#define ALT_J 0x1aa
+#define ALT_K 0x1ab
+#define ALT_L 0x1ac
+#define ALT_M 0x1ad
+#define ALT_N 0x1ae
+#define ALT_O 0x1af
+#define ALT_P 0x1b0
+#define ALT_Q 0x1b1
+#define ALT_R 0x1b2
+#define ALT_S 0x1b3
+#define ALT_T 0x1b4
+#define ALT_U 0x1b5
+#define ALT_V 0x1b6
+#define ALT_W 0x1b7
+#define ALT_X 0x1b8
+#define ALT_Y 0x1b9
+#define ALT_Z 0x1ba
+
+#define CTL_LEFT 0x1bb /* Control-Left-Arrow */
+#define CTL_RIGHT 0x1bc
+#define CTL_PGUP 0x1bd
+#define CTL_PGDN 0x1be
+#define CTL_HOME 0x1bf
+#define CTL_END 0x1c0
+
+#define KEY_A1 0x1c1 /* upper left on Virtual keypad */
+#define KEY_A2 0x1c2 /* upper middle on Virt. keypad */
+#define KEY_A3 0x1c3 /* upper right on Vir. keypad */
+#define KEY_B1 0x1c4 /* middle left on Virt. keypad */
+#define KEY_B2 0x1c5 /* center on Virt. keypad */
+#define KEY_B3 0x1c6 /* middle right on Vir. keypad */
+#define KEY_C1 0x1c7 /* lower left on Virt. keypad */
+#define KEY_C2 0x1c8 /* lower middle on Virt. keypad */
+#define KEY_C3 0x1c9 /* lower right on Vir. keypad */
+
+#define PADSLASH 0x1ca /* slash on keypad */
+#define PADENTER 0x1cb /* enter on keypad */
+#define CTL_PADENTER 0x1cc /* ctl-enter on keypad */
+#define ALT_PADENTER 0x1cd /* alt-enter on keypad */
+#define PADSTOP 0x1ce /* stop on keypad */
+#define PADSTAR 0x1cf /* star on keypad */
+#define PADMINUS 0x1d0 /* minus on keypad */
+#define PADPLUS 0x1d1 /* plus on keypad */
+#define CTL_PADSTOP 0x1d2 /* ctl-stop on keypad */
+#define CTL_PADCENTER 0x1d3 /* ctl-enter on keypad */
+#define CTL_PADPLUS 0x1d4 /* ctl-plus on keypad */
+#define CTL_PADMINUS 0x1d5 /* ctl-minus on keypad */
+#define CTL_PADSLASH 0x1d6 /* ctl-slash on keypad */
+#define CTL_PADSTAR 0x1d7 /* ctl-star on keypad */
+#define ALT_PADPLUS 0x1d8 /* alt-plus on keypad */
+#define ALT_PADMINUS 0x1d9 /* alt-minus on keypad */
+#define ALT_PADSLASH 0x1da /* alt-slash on keypad */
+#define ALT_PADSTAR 0x1db /* alt-star on keypad */
+#define ALT_PADSTOP 0x1dc /* alt-stop on keypad */
+#define CTL_INS 0x1dd /* ctl-insert */
+#define ALT_DEL 0x1de /* alt-delete */
+#define ALT_INS 0x1df /* alt-insert */
+#define CTL_UP 0x1e0 /* ctl-up arrow */
+#define CTL_DOWN 0x1e1 /* ctl-down arrow */
+#define CTL_TAB 0x1e2 /* ctl-tab */
+#define ALT_TAB 0x1e3
+#define ALT_MINUS 0x1e4
+#define ALT_EQUAL 0x1e5
+#define ALT_HOME 0x1e6
+#define ALT_PGUP 0x1e7
+#define ALT_PGDN 0x1e8
+#define ALT_END 0x1e9
+#define ALT_UP 0x1ea /* alt-up arrow */
+#define ALT_DOWN 0x1eb /* alt-down arrow */
+#define ALT_RIGHT 0x1ec /* alt-right arrow */
+#define ALT_LEFT 0x1ed /* alt-left arrow */
+#define ALT_ENTER 0x1ee /* alt-enter */
+#define ALT_ESC 0x1ef /* alt-escape */
+#define ALT_BQUOTE 0x1f0 /* alt-back quote */
+#define ALT_LBRACKET 0x1f1 /* alt-left bracket */
+#define ALT_RBRACKET 0x1f2 /* alt-right bracket */
+#define ALT_SEMICOLON 0x1f3 /* alt-semi-colon */
+#define ALT_FQUOTE 0x1f4 /* alt-forward quote */
+#define ALT_COMMA 0x1f5 /* alt-comma */
+#define ALT_STOP 0x1f6 /* alt-stop */
+#define ALT_FSLASH 0x1f7 /* alt-forward slash */
+#define ALT_BKSP 0x1f8 /* alt-backspace */
+#define CTL_BKSP 0x1f9 /* ctl-backspace */
+#define PAD0 0x1fa /* keypad 0 */
+
+#define CTL_PAD0 0x1fb /* ctl-keypad 0 */
+#define CTL_PAD1 0x1fc
+#define CTL_PAD2 0x1fd
+#define CTL_PAD3 0x1fe
+#define CTL_PAD4 0x1ff
+#define CTL_PAD5 0x200
+#define CTL_PAD6 0x201
+#define CTL_PAD7 0x202
+#define CTL_PAD8 0x203
+#define CTL_PAD9 0x204
+
+#define ALT_PAD0 0x205 /* alt-keypad 0 */
+#define ALT_PAD1 0x206
+#define ALT_PAD2 0x207
+#define ALT_PAD3 0x208
+#define ALT_PAD4 0x209
+#define ALT_PAD5 0x20a
+#define ALT_PAD6 0x20b
+#define ALT_PAD7 0x20c
+#define ALT_PAD8 0x20d
+#define ALT_PAD9 0x20e
+
+#define CTL_DEL 0x20f /* clt-delete */
+#define ALT_BSLASH 0x210 /* alt-back slash */
+#define CTL_ENTER 0x211 /* ctl-enter */
+
+#define SHF_PADENTER 0x212 /* shift-enter on keypad */
+#define SHF_PADSLASH 0x213 /* shift-slash on keypad */
+#define SHF_PADSTAR 0x214 /* shift-star on keypad */
+#define SHF_PADPLUS 0x215 /* shift-plus on keypad */
+#define SHF_PADMINUS 0x216 /* shift-minus on keypad */
+#define SHF_UP 0x217 /* shift-up on keypad */
+#define SHF_DOWN 0x218 /* shift-down on keypad */
+#define SHF_IC 0x219 /* shift-insert on keypad */
+#define SHF_DC 0x21a /* shift-delete on keypad */
+
+#define KEY_MOUSE 0x21b /* "mouse" key */
+#define KEY_SHIFT_L 0x21c /* Left-shift */
+#define KEY_SHIFT_R 0x21d /* Right-shift */
+#define KEY_CONTROL_L 0x21e /* Left-control */
+#define KEY_CONTROL_R 0x21f /* Right-control */
+#define KEY_ALT_L 0x220 /* Left-alt */
+#define KEY_ALT_R 0x221 /* Right-alt */
+#define KEY_RESIZE 0x222 /* Window resize */
+#define KEY_SUP 0x223 /* Shifted up arrow */
+#define KEY_SDOWN 0x224 /* Shifted down arrow */
+
+#define KEY_MIN KEY_BREAK /* Minimum curses key value */
+#define KEY_MAX KEY_SDOWN /* Maximum curses key */
+
+#define KEY_F(n) (KEY_F0 + (n))
+
+/*----------------------------------------------------------------------
+ *
+ * PDCurses Function Declarations
+ *
+ */
+
+/* Standard */
+
+int addch(const chtype);
+int addchnstr(const chtype *, int);
+int addchstr(const chtype *);
+int addnstr(const char *, int);
+int addstr(const char *);
+int attroff(chtype);
+int attron(chtype);
+int attrset(chtype);
+int attr_get(attr_t *, short *, void *);
+int attr_off(attr_t, void *);
+int attr_on(attr_t, void *);
+int attr_set(attr_t, short, void *);
+int baudrate(void);
+int beep(void);
+int bkgd(chtype);
+void bkgdset(chtype);
+int border(chtype, chtype, chtype, chtype, chtype, chtype, chtype, chtype);
+int box(WINDOW *, chtype, chtype);
+bool can_change_color(void);
+int cbreak(void);
+int chgat(int, attr_t, short, const void *);
+int clearok(WINDOW *, bool);
+int clear(void);
+int clrtobot(void);
+int clrtoeol(void);
+int color_content(short, short *, short *, short *);
+int color_set(short, void *);
+int copywin(const WINDOW *, WINDOW *, int, int, int, int, int, int, int);
+int curs_set(int);
+int def_prog_mode(void);
+int def_shell_mode(void);
+int delay_output(int);
+int delch(void);
+int deleteln(void);
+void delscreen(SCREEN *);
+int delwin(WINDOW *);
+WINDOW *derwin(WINDOW *, int, int, int, int);
+int doupdate(void);
+WINDOW *dupwin(WINDOW *);
+int echochar(const chtype);
+int echo(void);
+int endwin(void);
+char erasechar(void);
+int erase(void);
+void filter(void);
+int flash(void);
+int flushinp(void);
+chtype getbkgd(WINDOW *);
+int getnstr(char *, int);
+int getstr(char *);
+WINDOW *getwin(FILE *);
+int halfdelay(int);
+bool has_colors(void);
+bool has_ic(void);
+bool has_il(void);
+int hline(chtype, int);
+void idcok(WINDOW *, bool);
+int idlok(WINDOW *, bool);
+void immedok(WINDOW *, bool);
+int inchnstr(chtype *, int);
+int inchstr(chtype *);
+chtype inch(void);
+int init_color(short, short, short, short);
+int init_pair(short, short, short);
+WINDOW *initscr(void);
+int innstr(char *, int);
+int insch(chtype);
+int insdelln(int);
+int insertln(void);
+int insnstr(const char *, int);
+int insstr(const char *);
+int instr(char *);
+int intrflush(WINDOW *, bool);
+bool isendwin(void);
+bool is_linetouched(WINDOW *, int);
+bool is_wintouched(WINDOW *);
+char *keyname(int);
+int keypad(WINDOW *, bool);
+char killchar(void);
+int leaveok(WINDOW *, bool);
+char *longname(void);
+int meta(WINDOW *, bool);
+int move(int, int);
+int mvaddch(int, int, const chtype);
+int mvaddchnstr(int, int, const chtype *, int);
+int mvaddchstr(int, int, const chtype *);
+int mvaddnstr(int, int, const char *, int);
+int mvaddstr(int, int, const char *);
+int mvchgat(int, int, int, attr_t, short, const void *);
+int mvcur(int, int, int, int);
+int mvdelch(int, int);
+int mvderwin(WINDOW *, int, int);
+int mvgetch(int, int);
+int mvgetnstr(int, int, char *, int);
+int mvgetstr(int, int, char *);
+int mvhline(int, int, chtype, int);
+chtype mvinch(int, int);
+int mvinchnstr(int, int, chtype *, int);
+int mvinchstr(int, int, chtype *);
+int mvinnstr(int, int, char *, int);
+int mvinsch(int, int, chtype);
+int mvinsnstr(int, int, const char *, int);
+int mvinsstr(int, int, const char *);
+int mvinstr(int, int, char *);
+int mvprintw(int, int, const char *, ...);
+int mvscanw(int, int, const char *, ...);
+int mvvline(int, int, chtype, int);
+int mvwaddchnstr(WINDOW *, int, int, const chtype *, int);
+int mvwaddchstr(WINDOW *, int, int, const chtype *);
+int mvwaddch(WINDOW *, int, int, const chtype);
+int mvwaddnstr(WINDOW *, int, int, const char *, int);
+int mvwaddstr(WINDOW *, int, int, const char *);
+int mvwchgat(WINDOW *, int, int, int, attr_t, short, const void *);
+int mvwdelch(WINDOW *, int, int);
+int mvwgetch(WINDOW *, int, int);
+int mvwgetnstr(WINDOW *, int, int, char *, int);
+int mvwgetstr(WINDOW *, int, int, char *);
+int mvwhline(WINDOW *, int, int, chtype, int);
+int mvwinchnstr(WINDOW *, int, int, chtype *, int);
+int mvwinchstr(WINDOW *, int, int, chtype *);
+chtype mvwinch(WINDOW *, int, int);
+int mvwinnstr(WINDOW *, int, int, char *, int);
+int mvwinsch(WINDOW *, int, int, chtype);
+int mvwinsnstr(WINDOW *, int, int, const char *, int);
+int mvwinsstr(WINDOW *, int, int, const char *);
+int mvwinstr(WINDOW *, int, int, char *);
+int mvwin(WINDOW *, int, int);
+int mvwprintw(WINDOW *, int, int, const char *, ...);
+int mvwscanw(WINDOW *, int, int, const char *, ...);
+int mvwvline(WINDOW *, int, int, chtype, int);
+int napms(int);
+WINDOW *newpad(int, int);
+SCREEN *newterm(const char *, FILE *, FILE *);
+WINDOW *newwin(int, int, int, int);
+int nl(void);
+int nocbreak(void);
+int nodelay(WINDOW *, bool);
+int noecho(void);
+int nonl(void);
+void noqiflush(void);
+int noraw(void);
+int notimeout(WINDOW *, bool);
+int overlay(const WINDOW *, WINDOW *);
+int overwrite(const WINDOW *, WINDOW *);
+int pair_content(short, short *, short *);
+int pechochar(WINDOW *, chtype);
+int pnoutrefresh(WINDOW *, int, int, int, int, int, int);
+int prefresh(WINDOW *, int, int, int, int, int, int);
+int printw(const char *, ...);
+int putwin(WINDOW *, FILE *);
+void qiflush(void);
+int raw(void);
+int redrawwin(WINDOW *);
+int refresh(void);
+int reset_prog_mode(void);
+int reset_shell_mode(void);
+int resetty(void);
+int ripoffline(int, int (*)(WINDOW *, int));
+int savetty(void);
+int scanw(const char *, ...);
+int scr_dump(const char *);
+int scr_init(const char *);
+int scr_restore(const char *);
+int scr_set(const char *);
+int scrl(int);
+int scroll(WINDOW *);
+int scrollok(WINDOW *, bool);
+SCREEN *set_term(SCREEN *);
+int setscrreg(int, int);
+int slk_attroff(const chtype);
+int slk_attr_off(const attr_t, void *);
+int slk_attron(const chtype);
+int slk_attr_on(const attr_t, void *);
+int slk_attrset(const chtype);
+int slk_attr_set(const attr_t, short, void *);
+int slk_clear(void);
+int slk_color(short);
+int slk_init(int);
+char *slk_label(int);
+int slk_noutrefresh(void);
+int slk_refresh(void);
+int slk_restore(void);
+int slk_set(int, const char *, int);
+int slk_touch(void);
+int standend(void);
+int standout(void);
+int start_color(void);
+WINDOW *subpad(WINDOW *, int, int, int, int);
+WINDOW *subwin(WINDOW *, int, int, int, int);
+int syncok(WINDOW *, bool);
+chtype termattrs(void);
+attr_t term_attrs(void);
+char *termname(void);
+void timeout(int);
+int touchline(WINDOW *, int, int);
+int touchwin(WINDOW *);
+int typeahead(int);
+int untouchwin(WINDOW *);
+void use_env(bool);
+int vidattr(chtype);
+int vid_attr(attr_t, short, void *);
+int vidputs(chtype, int (*)(int));
+int vid_puts(attr_t, short, void *, int (*)(int));
+int vline(chtype, int);
+int vw_printw(WINDOW *, const char *, va_list);
+int vwprintw(WINDOW *, const char *, va_list);
+int vw_scanw(WINDOW *, const char *, va_list);
+int vwscanw(WINDOW *, const char *, va_list);
+int waddchnstr(WINDOW *, const chtype *, int);
+int waddchstr(WINDOW *, const chtype *);
+int waddch(WINDOW *, const chtype);
+int waddnstr(WINDOW *, const char *, int);
+int waddstr(WINDOW *, const char *);
+int wattroff(WINDOW *, chtype);
+int wattron(WINDOW *, chtype);
+int wattrset(WINDOW *, chtype);
+int wattr_get(WINDOW *, attr_t *, short *, void *);
+int wattr_off(WINDOW *, attr_t, void *);
+int wattr_on(WINDOW *, attr_t, void *);
+int wattr_set(WINDOW *, attr_t, short, void *);
+void wbkgdset(WINDOW *, chtype);
+int wbkgd(WINDOW *, chtype);
+int wborder(WINDOW *, chtype, chtype, chtype, chtype,
+ chtype, chtype, chtype, chtype);
+int wchgat(WINDOW *, int, attr_t, short, const void *);
+int wclear(WINDOW *);
+int wclrtobot(WINDOW *);
+int wclrtoeol(WINDOW *);
+int wcolor_set(WINDOW *, short, void *);
+void wcursyncup(WINDOW *);
+int wdelch(WINDOW *);
+int wdeleteln(WINDOW *);
+int wechochar(WINDOW *, const chtype);
+int werase(WINDOW *);
+int wgetch(WINDOW *);
+int wgetnstr(WINDOW *, char *, int);
+int wgetstr(WINDOW *, char *);
+int whline(WINDOW *, chtype, int);
+int winchnstr(WINDOW *, chtype *, int);
+int winchstr(WINDOW *, chtype *);
+chtype winch(WINDOW *);
+int winnstr(WINDOW *, char *, int);
+int winsch(WINDOW *, chtype);
+int winsdelln(WINDOW *, int);
+int winsertln(WINDOW *);
+int winsnstr(WINDOW *, const char *, int);
+int winsstr(WINDOW *, const char *);
+int winstr(WINDOW *, char *);
+int wmove(WINDOW *, int, int);
+int wnoutrefresh(WINDOW *);
+int wprintw(WINDOW *, const char *, ...);
+int wredrawln(WINDOW *, int, int);
+int wrefresh(WINDOW *);
+int wscanw(WINDOW *, const char *, ...);
+int wscrl(WINDOW *, int);
+int wsetscrreg(WINDOW *, int, int);
+int wstandend(WINDOW *);
+int wstandout(WINDOW *);
+void wsyncdown(WINDOW *);
+void wsyncup(WINDOW *);
+void wtimeout(WINDOW *, int);
+int wtouchln(WINDOW *, int, int, int);
+int wvline(WINDOW *, chtype, int);
+
+/* Wide-character functions */
+
+#ifdef PDC_WIDE
+int addnwstr(const wchar_t *, int);
+int addwstr(const wchar_t *);
+int add_wch(const cchar_t *);
+int add_wchnstr(const cchar_t *, int);
+int add_wchstr(const cchar_t *);
+int border_set(const cchar_t *, const cchar_t *, const cchar_t *,
+ const cchar_t *, const cchar_t *, const cchar_t *,
+ const cchar_t *, const cchar_t *);
+int box_set(WINDOW *, const cchar_t *, const cchar_t *);
+int echo_wchar(const cchar_t *);
+int erasewchar(wchar_t *);
+int getbkgrnd(cchar_t *);
+int getcchar(const cchar_t *, wchar_t *, attr_t *, short *, void *);
+int getn_wstr(wint_t *, int);
+int get_wch(wint_t *);
+int get_wstr(wint_t *);
+int hline_set(const cchar_t *, int);
+int innwstr(wchar_t *, int);
+int ins_nwstr(const wchar_t *, int);
+int ins_wch(const cchar_t *);
+int ins_wstr(const wchar_t *);
+int inwstr(wchar_t *);
+int in_wch(cchar_t *);
+int in_wchnstr(cchar_t *, int);
+int in_wchstr(cchar_t *);
+char *key_name(wchar_t);
+int killwchar(wchar_t *);
+int mvaddnwstr(int, int, const wchar_t *, int);
+int mvaddwstr(int, int, const wchar_t *);
+int mvadd_wch(int, int, const cchar_t *);
+int mvadd_wchnstr(int, int, const cchar_t *, int);
+int mvadd_wchstr(int, int, const cchar_t *);
+int mvgetn_wstr(int, int, wint_t *, int);
+int mvget_wch(int, int, wint_t *);
+int mvget_wstr(int, int, wint_t *);
+int mvhline_set(int, int, const cchar_t *, int);
+int mvinnwstr(int, int, wchar_t *, int);
+int mvins_nwstr(int, int, const wchar_t *, int);
+int mvins_wch(int, int, const cchar_t *);
+int mvins_wstr(int, int, const wchar_t *);
+int mvinwstr(int, int, wchar_t *);
+int mvin_wch(int, int, cchar_t *);
+int mvin_wchnstr(int, int, cchar_t *, int);
+int mvin_wchstr(int, int, cchar_t *);
+int mvvline_set(int, int, const cchar_t *, int);
+int mvwaddnwstr(WINDOW *, int, int, const wchar_t *, int);
+int mvwaddwstr(WINDOW *, int, int, const wchar_t *);
+int mvwadd_wch(WINDOW *, int, int, const cchar_t *);
+int mvwadd_wchnstr(WINDOW *, int, int, const cchar_t *, int);
+int mvwadd_wchstr(WINDOW *, int, int, const cchar_t *);
+int mvwgetn_wstr(WINDOW *, int, int, wint_t *, int);
+int mvwget_wch(WINDOW *, int, int, wint_t *);
+int mvwget_wstr(WINDOW *, int, int, wint_t *);
+int mvwhline_set(WINDOW *, int, int, const cchar_t *, int);
+int mvwinnwstr(WINDOW *, int, int, wchar_t *, int);
+int mvwins_nwstr(WINDOW *, int, int, const wchar_t *, int);
+int mvwins_wch(WINDOW *, int, int, const cchar_t *);
+int mvwins_wstr(WINDOW *, int, int, const wchar_t *);
+int mvwin_wch(WINDOW *, int, int, cchar_t *);
+int mvwin_wchnstr(WINDOW *, int, int, cchar_t *, int);
+int mvwin_wchstr(WINDOW *, int, int, cchar_t *);
+int mvwinwstr(WINDOW *, int, int, wchar_t *);
+int mvwvline_set(WINDOW *, int, int, const cchar_t *, int);
+int pecho_wchar(WINDOW *, const cchar_t*);
+int setcchar(cchar_t*, const wchar_t*, const attr_t, short, const void*);
+int slk_wset(int, const wchar_t *, int);
+int unget_wch(const wchar_t);
+int vline_set(const cchar_t *, int);
+int waddnwstr(WINDOW *, const wchar_t *, int);
+int waddwstr(WINDOW *, const wchar_t *);
+int wadd_wch(WINDOW *, const cchar_t *);
+int wadd_wchnstr(WINDOW *, const cchar_t *, int);
+int wadd_wchstr(WINDOW *, const cchar_t *);
+int wbkgrnd(WINDOW *, const cchar_t *);
+void wbkgrndset(WINDOW *, const cchar_t *);
+int wborder_set(WINDOW *, const cchar_t *, const cchar_t *,
+ const cchar_t *, const cchar_t *, const cchar_t *,
+ const cchar_t *, const cchar_t *, const cchar_t *);
+int wecho_wchar(WINDOW *, const cchar_t *);
+int wgetbkgrnd(WINDOW *, cchar_t *);
+int wgetn_wstr(WINDOW *, wint_t *, int);
+int wget_wch(WINDOW *, wint_t *);
+int wget_wstr(WINDOW *, wint_t *);
+int whline_set(WINDOW *, const cchar_t *, int);
+int winnwstr(WINDOW *, wchar_t *, int);
+int wins_nwstr(WINDOW *, const wchar_t *, int);
+int wins_wch(WINDOW *, const cchar_t *);
+int wins_wstr(WINDOW *, const wchar_t *);
+int winwstr(WINDOW *, wchar_t *);
+int win_wch(WINDOW *, cchar_t *);
+int win_wchnstr(WINDOW *, cchar_t *, int);
+int win_wchstr(WINDOW *, cchar_t *);
+wchar_t *wunctrl(cchar_t *);
+int wvline_set(WINDOW *, const cchar_t *, int);
+#endif
+
+/* Quasi-standard */
+
+chtype getattrs(WINDOW *);
+int getbegx(WINDOW *);
+int getbegy(WINDOW *);
+int getmaxx(WINDOW *);
+int getmaxy(WINDOW *);
+int getparx(WINDOW *);
+int getpary(WINDOW *);
+int getcurx(WINDOW *);
+int getcury(WINDOW *);
+void traceoff(void);
+void traceon(void);
+char *unctrl(chtype);
+
+int crmode(void);
+int nocrmode(void);
+int draino(int);
+int resetterm(void);
+int fixterm(void);
+int saveterm(void);
+int setsyx(int, int);
+
+int mouse_set(unsigned long);
+int mouse_on(unsigned long);
+int mouse_off(unsigned long);
+int request_mouse_pos(void);
+int map_button(unsigned long);
+void wmouse_position(WINDOW *, int *, int *);
+unsigned long getmouse(void);
+unsigned long getbmap(void);
+
+/* ncurses */
+
+int assume_default_colors(int, int);
+const char *curses_version(void);
+bool has_key(int);
+int use_default_colors(void);
+int wresize(WINDOW *, int, int);
+
+int mouseinterval(int);
+mmask_t mousemask(mmask_t, mmask_t *);
+bool mouse_trafo(int *, int *, bool);
+int nc_getmouse(MEVENT *);
+int ungetmouse(MEVENT *);
+bool wenclose(const WINDOW *, int, int);
+bool wmouse_trafo(const WINDOW *, int *, int *, bool);
+
+/* PDCurses */
+
+int addrawch(chtype);
+int insrawch(chtype);
+bool is_termresized(void);
+int mvaddrawch(int, int, chtype);
+int mvdeleteln(int, int);
+int mvinsertln(int, int);
+int mvinsrawch(int, int, chtype);
+int mvwaddrawch(WINDOW *, int, int, chtype);
+int mvwdeleteln(WINDOW *, int, int);
+int mvwinsertln(WINDOW *, int, int);
+int mvwinsrawch(WINDOW *, int, int, chtype);
+int raw_output(bool);
+int resize_term(int, int);
+WINDOW *resize_window(WINDOW *, int, int);
+int waddrawch(WINDOW *, chtype);
+int winsrawch(WINDOW *, chtype);
+char wordchar(void);
+
+#ifdef PDC_WIDE
+wchar_t *slk_wlabel(int);
+#endif
+
+void PDC_debug(const char *, ...);
+int PDC_ungetch(int);
+int PDC_set_blink(bool);
+int PDC_set_line_color(short);
+void PDC_set_title(const char *);
+
+int PDC_clearclipboard(void);
+int PDC_freeclipboard(char *);
+int PDC_getclipboard(char **, long *);
+int PDC_setclipboard(const char *, long);
+
+unsigned long PDC_get_input_fd(void);
+unsigned long PDC_get_key_modifiers(void);
+int PDC_return_key_modifiers(bool);
+int PDC_save_key_modifiers(bool);
+
+#ifdef XCURSES
+WINDOW *Xinitscr(int, char **);
+void XCursesExit(void);
+int sb_init(void);
+int sb_set_horz(int, int, int);
+int sb_set_vert(int, int, int);
+int sb_get_horz(int *, int *, int *);
+int sb_get_vert(int *, int *, int *);
+int sb_refresh(void);
+#endif
+
+/*** Functions defined as macros ***/
+
+/* getch() and ungetch() conflict with some DOS libraries */
+
+#define getch() wgetch(stdscr)
+#define ungetch(ch) PDC_ungetch(ch)
+
+#define COLOR_PAIR(n) (((chtype)(n) << PDC_COLOR_SHIFT) & A_COLOR)
+#define PAIR_NUMBER(n) (((n) & A_COLOR) >> PDC_COLOR_SHIFT)
+
+/* These will _only_ work as macros */
+
+#define getbegyx(w, y, x) (y = getbegy(w), x = getbegx(w))
+#define getmaxyx(w, y, x) (y = getmaxy(w), x = getmaxx(w))
+#define getparyx(w, y, x) (y = getpary(w), x = getparx(w))
+#define getyx(w, y, x) (y = getcury(w), x = getcurx(w))
+
+#define getsyx(y, x) { if (curscr->_leaveit) (y)=(x)=-1; \
+ else getyx(curscr,(y),(x)); }
+
+#ifdef NCURSES_MOUSE_VERSION
+# define getmouse(x) nc_getmouse(x)
+#endif
+
+/* return codes from PDC_getclipboard() and PDC_setclipboard() calls */
+
+#define PDC_CLIP_SUCCESS 0
+#define PDC_CLIP_ACCESS_ERROR 1
+#define PDC_CLIP_EMPTY 2
+#define PDC_CLIP_MEMORY_ERROR 3
+
+/* PDCurses key modifier masks */
+
+#define PDC_KEY_MODIFIER_SHIFT 1
+#define PDC_KEY_MODIFIER_CONTROL 2
+#define PDC_KEY_MODIFIER_ALT 4
+#define PDC_KEY_MODIFIER_NUMLOCK 8
+
+#if defined(__cplusplus) || defined(__cplusplus__) || defined(__CPLUSPLUS)
+# undef bool
+}
+#endif
+
+#endif /* __PDCURSES__ */
--- /dev/null
+/* zconf.h -- configuration of the zlib compression library
+ * Copyright (C) 1995-2005 Jean-loup Gailly.
+ * For conditions of distribution and use, see copyright notice in zlib.h
+ */
+
+/* @(#) $Id$ */
+
+#ifndef ZCONF_H
+#define ZCONF_H
+
+/*
+ * If you *really* need a unique prefix for all types and library functions,
+ * compile with -DZ_PREFIX. The "standard" zlib should be compiled without it.
+ */
+#ifdef Z_PREFIX
+# define deflateInit_ z_deflateInit_
+# define deflate z_deflate
+# define deflateEnd z_deflateEnd
+# define inflateInit_ z_inflateInit_
+# define inflate z_inflate
+# define inflateEnd z_inflateEnd
+# define deflateInit2_ z_deflateInit2_
+# define deflateSetDictionary z_deflateSetDictionary
+# define deflateCopy z_deflateCopy
+# define deflateReset z_deflateReset
+# define deflateParams z_deflateParams
+# define deflateBound z_deflateBound
+# define deflatePrime z_deflatePrime
+# define inflateInit2_ z_inflateInit2_
+# define inflateSetDictionary z_inflateSetDictionary
+# define inflateSync z_inflateSync
+# define inflateSyncPoint z_inflateSyncPoint
+# define inflateCopy z_inflateCopy
+# define inflateReset z_inflateReset
+# define inflateBack z_inflateBack
+# define inflateBackEnd z_inflateBackEnd
+# define compress z_compress
+# define compress2 z_compress2
+# define compressBound z_compressBound
+# define uncompress z_uncompress
+# define adler32 z_adler32
+# define crc32 z_crc32
+# define get_crc_table z_get_crc_table
+# define zError z_zError
+
+# define alloc_func z_alloc_func
+# define free_func z_free_func
+# define in_func z_in_func
+# define out_func z_out_func
+# define Byte z_Byte
+# define uInt z_uInt
+# define uLong z_uLong
+# define Bytef z_Bytef
+# define charf z_charf
+# define intf z_intf
+# define uIntf z_uIntf
+# define uLongf z_uLongf
+# define voidpf z_voidpf
+# define voidp z_voidp
+#endif
+
+#if defined(__MSDOS__) && !defined(MSDOS)
+# define MSDOS
+#endif
+#if (defined(OS_2) || defined(__OS2__)) && !defined(OS2)
+# define OS2
+#endif
+#if defined(_WINDOWS) && !defined(WINDOWS)
+# define WINDOWS
+#endif
+#if defined(_WIN32) || defined(_WIN32_WCE) || defined(__WIN32__)
+# ifndef WIN32
+# define WIN32
+# endif
+#endif
+#if (defined(MSDOS) || defined(OS2) || defined(WINDOWS)) && !defined(WIN32)
+# if !defined(__GNUC__) && !defined(__FLAT__) && !defined(__386__)
+# ifndef SYS16BIT
+# define SYS16BIT
+# endif
+# endif
+#endif
+
+/*
+ * Compile with -DMAXSEG_64K if the alloc function cannot allocate more
+ * than 64k bytes at a time (needed on systems with 16-bit int).
+ */
+#ifdef SYS16BIT
+# define MAXSEG_64K
+#endif
+#ifdef MSDOS
+# define UNALIGNED_OK
+#endif
+
+#ifdef __STDC_VERSION__
+# ifndef STDC
+# define STDC
+# endif
+# if __STDC_VERSION__ >= 199901L
+# ifndef STDC99
+# define STDC99
+# endif
+# endif
+#endif
+#if !defined(STDC) && (defined(__STDC__) || defined(__cplusplus))
+# define STDC
+#endif
+#if !defined(STDC) && (defined(__GNUC__) || defined(__BORLANDC__))
+# define STDC
+#endif
+#if !defined(STDC) && (defined(MSDOS) || defined(WINDOWS) || defined(WIN32))
+# define STDC
+#endif
+#if !defined(STDC) && (defined(OS2) || defined(__HOS_AIX__))
+# define STDC
+#endif
+
+#if defined(__OS400__) && !defined(STDC) /* iSeries (formerly AS/400). */
+# define STDC
+#endif
+
+#ifndef STDC
+# ifndef const /* cannot use !defined(STDC) && !defined(const) on Mac */
+# define const /* note: need a more gentle solution here */
+# endif
+#endif
+
+/* Some Mac compilers merge all .h files incorrectly: */
+#if defined(__MWERKS__)||defined(applec)||defined(THINK_C)||defined(__SC__)
+# define NO_DUMMY_DECL
+#endif
+
+/* Maximum value for memLevel in deflateInit2 */
+#ifndef MAX_MEM_LEVEL
+# ifdef MAXSEG_64K
+# define MAX_MEM_LEVEL 8
+# else
+# define MAX_MEM_LEVEL 9
+# endif
+#endif
+
+/* Maximum value for windowBits in deflateInit2 and inflateInit2.
+ * WARNING: reducing MAX_WBITS makes minigzip unable to extract .gz files
+ * created by gzip. (Files created by minigzip can still be extracted by
+ * gzip.)
+ */
+#ifndef MAX_WBITS
+# define MAX_WBITS 15 /* 32K LZ77 window */
+#endif
+
+/* The memory requirements for deflate are (in bytes):
+ (1 << (windowBits+2)) + (1 << (memLevel+9))
+ that is: 128K for windowBits=15 + 128K for memLevel = 8 (default values)
+ plus a few kilobytes for small objects. For example, if you want to reduce
+ the default memory requirements from 256K to 128K, compile with
+ make CFLAGS="-O -DMAX_WBITS=14 -DMAX_MEM_LEVEL=7"
+ Of course this will generally degrade compression (there's no free lunch).
+
+ The memory requirements for inflate are (in bytes) 1 << windowBits
+ that is, 32K for windowBits=15 (default value) plus a few kilobytes
+ for small objects.
+*/
+
+ /* Type declarations */
+
+#ifndef OF /* function prototypes */
+# ifdef STDC
+# define OF(args) args
+# else
+# define OF(args) ()
+# endif
+#endif
+
+/* The following definitions for FAR are needed only for MSDOS mixed
+ * model programming (small or medium model with some far allocations).
+ * This was tested only with MSC; for other MSDOS compilers you may have
+ * to define NO_MEMCPY in zutil.h. If you don't need the mixed model,
+ * just define FAR to be empty.
+ */
+#ifdef SYS16BIT
+# if defined(M_I86SM) || defined(M_I86MM)
+ /* MSC small or medium model */
+# define SMALL_MEDIUM
+# ifdef _MSC_VER
+# define FAR _far
+# else
+# define FAR far
+# endif
+# endif
+# if (defined(__SMALL__) || defined(__MEDIUM__))
+ /* Turbo C small or medium model */
+# define SMALL_MEDIUM
+# ifdef __BORLANDC__
+# define FAR _far
+# else
+# define FAR far
+# endif
+# endif
+#endif
+
+#if defined(WINDOWS) || defined(WIN32)
+ /* If building or using zlib as a DLL, define ZLIB_DLL.
+ * This is not mandatory, but it offers a little performance increase.
+ */
+# ifdef ZLIB_DLL
+# if defined(WIN32) && (!defined(__BORLANDC__) || (__BORLANDC__ >= 0x500))
+# ifdef ZLIB_INTERNAL
+# define ZEXTERN extern __declspec(dllexport)
+# else
+# define ZEXTERN extern __declspec(dllimport)
+# endif
+# endif
+# endif /* ZLIB_DLL */
+ /* If building or using zlib with the WINAPI/WINAPIV calling convention,
+ * define ZLIB_WINAPI.
+ * Caution: the standard ZLIB1.DLL is NOT compiled using ZLIB_WINAPI.
+ */
+# ifdef ZLIB_WINAPI
+# ifdef FAR
+# undef FAR
+# endif
+# include <windows.h>
+ /* No need for _export, use ZLIB.DEF instead. */
+ /* For complete Windows compatibility, use WINAPI, not __stdcall. */
+# define ZEXPORT WINAPI
+# ifdef WIN32
+# define ZEXPORTVA WINAPIV
+# else
+# define ZEXPORTVA FAR CDECL
+# endif
+# endif
+#endif
+
+#if defined (__BEOS__)
+# ifdef ZLIB_DLL
+# ifdef ZLIB_INTERNAL
+# define ZEXPORT __declspec(dllexport)
+# define ZEXPORTVA __declspec(dllexport)
+# else
+# define ZEXPORT __declspec(dllimport)
+# define ZEXPORTVA __declspec(dllimport)
+# endif
+# endif
+#endif
+
+#ifndef ZEXTERN
+# define ZEXTERN extern
+#endif
+#ifndef ZEXPORT
+# define ZEXPORT
+#endif
+#ifndef ZEXPORTVA
+# define ZEXPORTVA
+#endif
+
+#ifndef FAR
+# define FAR
+#endif
+
+#if !defined(__MACTYPES__)
+typedef unsigned char Byte; /* 8 bits */
+#endif
+typedef unsigned int uInt; /* 16 bits or more */
+typedef unsigned long uLong; /* 32 bits or more */
+
+#ifdef SMALL_MEDIUM
+ /* Borland C/C++ and some old MSC versions ignore FAR inside typedef */
+# define Bytef Byte FAR
+#else
+ typedef Byte FAR Bytef;
+#endif
+typedef char FAR charf;
+typedef int FAR intf;
+typedef uInt FAR uIntf;
+typedef uLong FAR uLongf;
+
+#ifdef STDC
+ typedef void const *voidpc;
+ typedef void FAR *voidpf;
+ typedef void *voidp;
+#else
+ typedef Byte const *voidpc;
+ typedef Byte FAR *voidpf;
+ typedef Byte *voidp;
+#endif
+
+#if 0 /* HAVE_UNISTD_H -- this line is updated by ./configure */
+# include <sys/types.h> /* for off_t */
+# include <unistd.h> /* for SEEK_* and off_t */
+# ifdef VMS
+# include <unixio.h> /* for off_t */
+# endif
+# define z_off_t off_t
+#endif
+#ifndef SEEK_SET
+# define SEEK_SET 0 /* Seek from beginning of file. */
+# define SEEK_CUR 1 /* Seek from current position. */
+# define SEEK_END 2 /* Set file pointer to EOF plus "offset" */
+#endif
+#ifndef z_off_t
+# define z_off_t long
+#endif
+
+#if defined(__OS400__)
+# define NO_vsnprintf
+#endif
+
+#if defined(__MVS__)
+# define NO_vsnprintf
+# ifdef FAR
+# undef FAR
+# endif
+#endif
+
+/* MVS linker does not support external names larger than 8 bytes */
+#if defined(__MVS__)
+# pragma map(deflateInit_,"DEIN")
+# pragma map(deflateInit2_,"DEIN2")
+# pragma map(deflateEnd,"DEEND")
+# pragma map(deflateBound,"DEBND")
+# pragma map(inflateInit_,"ININ")
+# pragma map(inflateInit2_,"ININ2")
+# pragma map(inflateEnd,"INEND")
+# pragma map(inflateSync,"INSY")
+# pragma map(inflateSetDictionary,"INSEDI")
+# pragma map(compressBound,"CMBND")
+# pragma map(inflate_table,"INTABL")
+# pragma map(inflate_fast,"INFA")
+# pragma map(inflate_copyright,"INCOPY")
+#endif
+
+#endif /* ZCONF_H */
--- /dev/null
+/* zlib.h -- interface of the 'zlib' general purpose compression library
+ version 1.2.3, July 18th, 2005
+
+ Copyright (C) 1995-2005 Jean-loup Gailly and Mark Adler
+
+ This software is provided 'as-is', without any express or implied
+ warranty. In no event will the authors be held liable for any damages
+ arising from the use of this software.
+
+ Permission is granted to anyone to use this software for any purpose,
+ including commercial applications, and to alter it and redistribute it
+ freely, subject to the following restrictions:
+
+ 1. The origin of this software must not be misrepresented; you must not
+ claim that you wrote the original software. If you use this software
+ in a product, an acknowledgment in the product documentation would be
+ appreciated but is not required.
+ 2. Altered source versions must be plainly marked as such, and must not be
+ misrepresented as being the original software.
+ 3. This notice may not be removed or altered from any source distribution.
+
+ Jean-loup Gailly Mark Adler
+ jloup@gzip.org madler@alumni.caltech.edu
+
+
+ The data format used by the zlib library is described by RFCs (Request for
+ Comments) 1950 to 1952 in the files http://www.ietf.org/rfc/rfc1950.txt
+ (zlib format), rfc1951.txt (deflate format) and rfc1952.txt (gzip format).
+*/
+
+#ifndef ZLIB_H
+#define ZLIB_H
+
+#include "zconf.h"
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+#define ZLIB_VERSION "1.2.3"
+#define ZLIB_VERNUM 0x1230
+
+/*
+ The 'zlib' compression library provides in-memory compression and
+ decompression functions, including integrity checks of the uncompressed
+ data. This version of the library supports only one compression method
+ (deflation) but other algorithms will be added later and will have the same
+ stream interface.
+
+ Compression can be done in a single step if the buffers are large
+ enough (for example if an input file is mmap'ed), or can be done by
+ repeated calls of the compression function. In the latter case, the
+ application must provide more input and/or consume the output
+ (providing more output space) before each call.
+
+ The compressed data format used by default by the in-memory functions is
+ the zlib format, which is a zlib wrapper documented in RFC 1950, wrapped
+ around a deflate stream, which is itself documented in RFC 1951.
+
+ The library also supports reading and writing files in gzip (.gz) format
+ with an interface similar to that of stdio using the functions that start
+ with "gz". The gzip format is different from the zlib format. gzip is a
+ gzip wrapper, documented in RFC 1952, wrapped around a deflate stream.
+
+ This library can optionally read and write gzip streams in memory as well.
+
+ The zlib format was designed to be compact and fast for use in memory
+ and on communications channels. The gzip format was designed for single-
+ file compression on file systems, has a larger header than zlib to maintain
+ directory information, and uses a different, slower check method than zlib.
+
+ The library does not install any signal handler. The decoder checks
+ the consistency of the compressed data, so the library should never
+ crash even in case of corrupted input.
+*/
+
+typedef voidpf (*alloc_func) OF((voidpf opaque, uInt items, uInt size));
+typedef void (*free_func) OF((voidpf opaque, voidpf address));
+
+struct internal_state;
+
+typedef struct z_stream_s {
+ Bytef *next_in; /* next input byte */
+ uInt avail_in; /* number of bytes available at next_in */
+ uLong total_in; /* total nb of input bytes read so far */
+
+ Bytef *next_out; /* next output byte should be put there */
+ uInt avail_out; /* remaining free space at next_out */
+ uLong total_out; /* total nb of bytes output so far */
+
+ char *msg; /* last error message, NULL if no error */
+ struct internal_state FAR *state; /* not visible by applications */
+
+ alloc_func zalloc; /* used to allocate the internal state */
+ free_func zfree; /* used to free the internal state */
+ voidpf opaque; /* private data object passed to zalloc and zfree */
+
+ int data_type; /* best guess about the data type: binary or text */
+ uLong adler; /* adler32 value of the uncompressed data */
+ uLong reserved; /* reserved for future use */
+} z_stream;
+
+typedef z_stream FAR *z_streamp;
+
+/*
+ gzip header information passed to and from zlib routines. See RFC 1952
+ for more details on the meanings of these fields.
+*/
+typedef struct gz_header_s {
+ int text; /* true if compressed data believed to be text */
+ uLong time; /* modification time */
+ int xflags; /* extra flags (not used when writing a gzip file) */
+ int os; /* operating system */
+ Bytef *extra; /* pointer to extra field or Z_NULL if none */
+ uInt extra_len; /* extra field length (valid if extra != Z_NULL) */
+ uInt extra_max; /* space at extra (only when reading header) */
+ Bytef *name; /* pointer to zero-terminated file name or Z_NULL */
+ uInt name_max; /* space at name (only when reading header) */
+ Bytef *comment; /* pointer to zero-terminated comment or Z_NULL */
+ uInt comm_max; /* space at comment (only when reading header) */
+ int hcrc; /* true if there was or will be a header crc */
+ int done; /* true when done reading gzip header (not used
+ when writing a gzip file) */
+} gz_header;
+
+typedef gz_header FAR *gz_headerp;
+
+/*
+ The application must update next_in and avail_in when avail_in has
+ dropped to zero. It must update next_out and avail_out when avail_out
+ has dropped to zero. The application must initialize zalloc, zfree and
+ opaque before calling the init function. All other fields are set by the
+ compression library and must not be updated by the application.
+
+ The opaque value provided by the application will be passed as the first
+ parameter for calls of zalloc and zfree. This can be useful for custom
+ memory management. The compression library attaches no meaning to the
+ opaque value.
+
+ zalloc must return Z_NULL if there is not enough memory for the object.
+ If zlib is used in a multi-threaded application, zalloc and zfree must be
+ thread safe.
+
+ On 16-bit systems, the functions zalloc and zfree must be able to allocate
+ exactly 65536 bytes, but will not be required to allocate more than this
+ if the symbol MAXSEG_64K is defined (see zconf.h). WARNING: On MSDOS,
+ pointers returned by zalloc for objects of exactly 65536 bytes *must*
+ have their offset normalized to zero. The default allocation function
+ provided by this library ensures this (see zutil.c). To reduce memory
+ requirements and avoid any allocation of 64K objects, at the expense of
+ compression ratio, compile the library with -DMAX_WBITS=14 (see zconf.h).
+
+ The fields total_in and total_out can be used for statistics or
+ progress reports. After compression, total_in holds the total size of
+ the uncompressed data and may be saved for use in the decompressor
+ (particularly if the decompressor wants to decompress everything in
+ a single step).
+*/
+
+ /* constants */
+
+#define Z_NO_FLUSH 0
+#define Z_PARTIAL_FLUSH 1 /* will be removed, use Z_SYNC_FLUSH instead */
+#define Z_SYNC_FLUSH 2
+#define Z_FULL_FLUSH 3
+#define Z_FINISH 4
+#define Z_BLOCK 5
+/* Allowed flush values; see deflate() and inflate() below for details */
+
+#define Z_OK 0
+#define Z_STREAM_END 1
+#define Z_NEED_DICT 2
+#define Z_ERRNO (-1)
+#define Z_STREAM_ERROR (-2)
+#define Z_DATA_ERROR (-3)
+#define Z_MEM_ERROR (-4)
+#define Z_BUF_ERROR (-5)
+#define Z_VERSION_ERROR (-6)
+/* Return codes for the compression/decompression functions. Negative
+ * values are errors, positive values are used for special but normal events.
+ */
+
+#define Z_NO_COMPRESSION 0
+#define Z_BEST_SPEED 1
+#define Z_BEST_COMPRESSION 9
+#define Z_DEFAULT_COMPRESSION (-1)
+/* compression levels */
+
+#define Z_FILTERED 1
+#define Z_HUFFMAN_ONLY 2
+#define Z_RLE 3
+#define Z_FIXED 4
+#define Z_DEFAULT_STRATEGY 0
+/* compression strategy; see deflateInit2() below for details */
+
+#define Z_BINARY 0
+#define Z_TEXT 1
+#define Z_ASCII Z_TEXT /* for compatibility with 1.2.2 and earlier */
+#define Z_UNKNOWN 2
+/* Possible values of the data_type field (though see inflate()) */
+
+#define Z_DEFLATED 8
+/* The deflate compression method (the only one supported in this version) */
+
+#define Z_NULL 0 /* for initializing zalloc, zfree, opaque */
+
+#define zlib_version zlibVersion()
+/* for compatibility with versions < 1.0.2 */
+
+ /* basic functions */
+
+ZEXTERN const char * ZEXPORT zlibVersion OF((void));
+/* The application can compare zlibVersion and ZLIB_VERSION for consistency.
+ If the first character differs, the library code actually used is
+ not compatible with the zlib.h header file used by the application.
+ This check is automatically made by deflateInit and inflateInit.
+ */
+
+/*
+ZEXTERN int ZEXPORT deflateInit OF((z_streamp strm, int level));
+
+ Initializes the internal stream state for compression. The fields
+ zalloc, zfree and opaque must be initialized before by the caller.
+ If zalloc and zfree are set to Z_NULL, deflateInit updates them to
+ use default allocation functions.
+
+ The compression level must be Z_DEFAULT_COMPRESSION, or between 0 and 9:
+ 1 gives best speed, 9 gives best compression, 0 gives no compression at
+ all (the input data is simply copied a block at a time).
+ Z_DEFAULT_COMPRESSION requests a default compromise between speed and
+ compression (currently equivalent to level 6).
+
+ deflateInit returns Z_OK if success, Z_MEM_ERROR if there was not
+ enough memory, Z_STREAM_ERROR if level is not a valid compression level,
+ Z_VERSION_ERROR if the zlib library version (zlib_version) is incompatible
+ with the version assumed by the caller (ZLIB_VERSION).
+ msg is set to null if there is no error message. deflateInit does not
+ perform any compression: this will be done by deflate().
+*/
+
+
+ZEXTERN int ZEXPORT deflate OF((z_streamp strm, int flush));
+/*
+ deflate compresses as much data as possible, and stops when the input
+ buffer becomes empty or the output buffer becomes full. It may introduce some
+ output latency (reading input without producing any output) except when
+ forced to flush.
+
+ The detailed semantics are as follows. deflate performs one or both of the
+ following actions:
+
+ - Compress more input starting at next_in and update next_in and avail_in
+ accordingly. If not all input can be processed (because there is not
+ enough room in the output buffer), next_in and avail_in are updated and
+ processing will resume at this point for the next call of deflate().
+
+ - Provide more output starting at next_out and update next_out and avail_out
+ accordingly. This action is forced if the parameter flush is non zero.
+ Forcing flush frequently degrades the compression ratio, so this parameter
+ should be set only when necessary (in interactive applications).
+ Some output may be provided even if flush is not set.
+
+ Before the call of deflate(), the application should ensure that at least
+ one of the actions is possible, by providing more input and/or consuming
+ more output, and updating avail_in or avail_out accordingly; avail_out
+ should never be zero before the call. The application can consume the
+ compressed output when it wants, for example when the output buffer is full
+ (avail_out == 0), or after each call of deflate(). If deflate returns Z_OK
+ and with zero avail_out, it must be called again after making room in the
+ output buffer because there might be more output pending.
+
+ Normally the parameter flush is set to Z_NO_FLUSH, which allows deflate to
+ decide how much data to accumualte before producing output, in order to
+ maximize compression.
+
+ If the parameter flush is set to Z_SYNC_FLUSH, all pending output is
+ flushed to the output buffer and the output is aligned on a byte boundary, so
+ that the decompressor can get all input data available so far. (In particular
+ avail_in is zero after the call if enough output space has been provided
+ before the call.) Flushing may degrade compression for some compression
+ algorithms and so it should be used only when necessary.
+
+ If flush is set to Z_FULL_FLUSH, all output is flushed as with
+ Z_SYNC_FLUSH, and the compression state is reset so that decompression can
+ restart from this point if previous compressed data has been damaged or if
+ random access is desired. Using Z_FULL_FLUSH too often can seriously degrade
+ compression.
+
+ If deflate returns with avail_out == 0, this function must be called again
+ with the same value of the flush parameter and more output space (updated
+ avail_out), until the flush is complete (deflate returns with non-zero
+ avail_out). In the case of a Z_FULL_FLUSH or Z_SYNC_FLUSH, make sure that
+ avail_out is greater than six to avoid repeated flush markers due to
+ avail_out == 0 on return.
+
+ If the parameter flush is set to Z_FINISH, pending input is processed,
+ pending output is flushed and deflate returns with Z_STREAM_END if there
+ was enough output space; if deflate returns with Z_OK, this function must be
+ called again with Z_FINISH and more output space (updated avail_out) but no
+ more input data, until it returns with Z_STREAM_END or an error. After
+ deflate has returned Z_STREAM_END, the only possible operations on the
+ stream are deflateReset or deflateEnd.
+
+ Z_FINISH can be used immediately after deflateInit if all the compression
+ is to be done in a single step. In this case, avail_out must be at least
+ the value returned by deflateBound (see below). If deflate does not return
+ Z_STREAM_END, then it must be called again as described above.
+
+ deflate() sets strm->adler to the adler32 checksum of all input read
+ so far (that is, total_in bytes).
+
+ deflate() may update strm->data_type if it can make a good guess about
+ the input data type (Z_BINARY or Z_TEXT). In doubt, the data is considered
+ binary. This field is only for information purposes and does not affect
+ the compression algorithm in any manner.
+
+ deflate() returns Z_OK if some progress has been made (more input
+ processed or more output produced), Z_STREAM_END if all input has been
+ consumed and all output has been produced (only when flush is set to
+ Z_FINISH), Z_STREAM_ERROR if the stream state was inconsistent (for example
+ if next_in or next_out was NULL), Z_BUF_ERROR if no progress is possible
+ (for example avail_in or avail_out was zero). Note that Z_BUF_ERROR is not
+ fatal, and deflate() can be called again with more input and more output
+ space to continue compressing.
+*/
+
+
+ZEXTERN int ZEXPORT deflateEnd OF((z_streamp strm));
+/*
+ All dynamically allocated data structures for this stream are freed.
+ This function discards any unprocessed input and does not flush any
+ pending output.
+
+ deflateEnd returns Z_OK if success, Z_STREAM_ERROR if the
+ stream state was inconsistent, Z_DATA_ERROR if the stream was freed
+ prematurely (some input or output was discarded). In the error case,
+ msg may be set but then points to a static string (which must not be
+ deallocated).
+*/
+
+
+/*
+ZEXTERN int ZEXPORT inflateInit OF((z_streamp strm));
+
+ Initializes the internal stream state for decompression. The fields
+ next_in, avail_in, zalloc, zfree and opaque must be initialized before by
+ the caller. If next_in is not Z_NULL and avail_in is large enough (the exact
+ value depends on the compression method), inflateInit determines the
+ compression method from the zlib header and allocates all data structures
+ accordingly; otherwise the allocation will be deferred to the first call of
+ inflate. If zalloc and zfree are set to Z_NULL, inflateInit updates them to
+ use default allocation functions.
+
+ inflateInit returns Z_OK if success, Z_MEM_ERROR if there was not enough
+ memory, Z_VERSION_ERROR if the zlib library version is incompatible with the
+ version assumed by the caller. msg is set to null if there is no error
+ message. inflateInit does not perform any decompression apart from reading
+ the zlib header if present: this will be done by inflate(). (So next_in and
+ avail_in may be modified, but next_out and avail_out are unchanged.)
+*/
+
+
+ZEXTERN int ZEXPORT inflate OF((z_streamp strm, int flush));
+/*
+ inflate decompresses as much data as possible, and stops when the input
+ buffer becomes empty or the output buffer becomes full. It may introduce
+ some output latency (reading input without producing any output) except when
+ forced to flush.
+
+ The detailed semantics are as follows. inflate performs one or both of the
+ following actions:
+
+ - Decompress more input starting at next_in and update next_in and avail_in
+ accordingly. If not all input can be processed (because there is not
+ enough room in the output buffer), next_in is updated and processing
+ will resume at this point for the next call of inflate().
+
+ - Provide more output starting at next_out and update next_out and avail_out
+ accordingly. inflate() provides as much output as possible, until there
+ is no more input data or no more space in the output buffer (see below
+ about the flush parameter).
+
+ Before the call of inflate(), the application should ensure that at least
+ one of the actions is possible, by providing more input and/or consuming
+ more output, and updating the next_* and avail_* values accordingly.
+ The application can consume the uncompressed output when it wants, for
+ example when the output buffer is full (avail_out == 0), or after each
+ call of inflate(). If inflate returns Z_OK and with zero avail_out, it
+ must be called again after making room in the output buffer because there
+ might be more output pending.
+
+ The flush parameter of inflate() can be Z_NO_FLUSH, Z_SYNC_FLUSH,
+ Z_FINISH, or Z_BLOCK. Z_SYNC_FLUSH requests that inflate() flush as much
+ output as possible to the output buffer. Z_BLOCK requests that inflate() stop
+ if and when it gets to the next deflate block boundary. When decoding the
+ zlib or gzip format, this will cause inflate() to return immediately after
+ the header and before the first block. When doing a raw inflate, inflate()
+ will go ahead and process the first block, and will return when it gets to
+ the end of that block, or when it runs out of data.
+
+ The Z_BLOCK option assists in appending to or combining deflate streams.
+ Also to assist in this, on return inflate() will set strm->data_type to the
+ number of unused bits in the last byte taken from strm->next_in, plus 64
+ if inflate() is currently decoding the last block in the deflate stream,
+ plus 128 if inflate() returned immediately after decoding an end-of-block
+ code or decoding the complete header up to just before the first byte of the
+ deflate stream. The end-of-block will not be indicated until all of the
+ uncompressed data from that block has been written to strm->next_out. The
+ number of unused bits may in general be greater than seven, except when
+ bit 7 of data_type is set, in which case the number of unused bits will be
+ less than eight.
+
+ inflate() should normally be called until it returns Z_STREAM_END or an
+ error. However if all decompression is to be performed in a single step
+ (a single call of inflate), the parameter flush should be set to
+ Z_FINISH. In this case all pending input is processed and all pending
+ output is flushed; avail_out must be large enough to hold all the
+ uncompressed data. (The size of the uncompressed data may have been saved
+ by the compressor for this purpose.) The next operation on this stream must
+ be inflateEnd to deallocate the decompression state. The use of Z_FINISH
+ is never required, but can be used to inform inflate that a faster approach
+ may be used for the single inflate() call.
+
+ In this implementation, inflate() always flushes as much output as
+ possible to the output buffer, and always uses the faster approach on the
+ first call. So the only effect of the flush parameter in this implementation
+ is on the return value of inflate(), as noted below, or when it returns early
+ because Z_BLOCK is used.
+
+ If a preset dictionary is needed after this call (see inflateSetDictionary
+ below), inflate sets strm->adler to the adler32 checksum of the dictionary
+ chosen by the compressor and returns Z_NEED_DICT; otherwise it sets
+ strm->adler to the adler32 checksum of all output produced so far (that is,
+ total_out bytes) and returns Z_OK, Z_STREAM_END or an error code as described
+ below. At the end of the stream, inflate() checks that its computed adler32
+ checksum is equal to that saved by the compressor and returns Z_STREAM_END
+ only if the checksum is correct.
+
+ inflate() will decompress and check either zlib-wrapped or gzip-wrapped
+ deflate data. The header type is detected automatically. Any information
+ contained in the gzip header is not retained, so applications that need that
+ information should instead use raw inflate, see inflateInit2() below, or
+ inflateBack() and perform their own processing of the gzip header and
+ trailer.
+
+ inflate() returns Z_OK if some progress has been made (more input processed
+ or more output produced), Z_STREAM_END if the end of the compressed data has
+ been reached and all uncompressed output has been produced, Z_NEED_DICT if a
+ preset dictionary is needed at this point, Z_DATA_ERROR if the input data was
+ corrupted (input stream not conforming to the zlib format or incorrect check
+ value), Z_STREAM_ERROR if the stream structure was inconsistent (for example
+ if next_in or next_out was NULL), Z_MEM_ERROR if there was not enough memory,
+ Z_BUF_ERROR if no progress is possible or if there was not enough room in the
+ output buffer when Z_FINISH is used. Note that Z_BUF_ERROR is not fatal, and
+ inflate() can be called again with more input and more output space to
+ continue decompressing. If Z_DATA_ERROR is returned, the application may then
+ call inflateSync() to look for a good compression block if a partial recovery
+ of the data is desired.
+*/
+
+
+ZEXTERN int ZEXPORT inflateEnd OF((z_streamp strm));
+/*
+ All dynamically allocated data structures for this stream are freed.
+ This function discards any unprocessed input and does not flush any
+ pending output.
+
+ inflateEnd returns Z_OK if success, Z_STREAM_ERROR if the stream state
+ was inconsistent. In the error case, msg may be set but then points to a
+ static string (which must not be deallocated).
+*/
+
+ /* Advanced functions */
+
+/*
+ The following functions are needed only in some special applications.
+*/
+
+/*
+ZEXTERN int ZEXPORT deflateInit2 OF((z_streamp strm,
+ int level,
+ int method,
+ int windowBits,
+ int memLevel,
+ int strategy));
+
+ This is another version of deflateInit with more compression options. The
+ fields next_in, zalloc, zfree and opaque must be initialized before by
+ the caller.
+
+ The method parameter is the compression method. It must be Z_DEFLATED in
+ this version of the library.
+
+ The windowBits parameter is the base two logarithm of the window size
+ (the size of the history buffer). It should be in the range 8..15 for this
+ version of the library. Larger values of this parameter result in better
+ compression at the expense of memory usage. The default value is 15 if
+ deflateInit is used instead.
+
+ windowBits can also be -8..-15 for raw deflate. In this case, -windowBits
+ determines the window size. deflate() will then generate raw deflate data
+ with no zlib header or trailer, and will not compute an adler32 check value.
+
+ windowBits can also be greater than 15 for optional gzip encoding. Add
+ 16 to windowBits to write a simple gzip header and trailer around the
+ compressed data instead of a zlib wrapper. The gzip header will have no
+ file name, no extra data, no comment, no modification time (set to zero),
+ no header crc, and the operating system will be set to 255 (unknown). If a
+ gzip stream is being written, strm->adler is a crc32 instead of an adler32.
+
+ The memLevel parameter specifies how much memory should be allocated
+ for the internal compression state. memLevel=1 uses minimum memory but
+ is slow and reduces compression ratio; memLevel=9 uses maximum memory
+ for optimal speed. The default value is 8. See zconf.h for total memory
+ usage as a function of windowBits and memLevel.
+
+ The strategy parameter is used to tune the compression algorithm. Use the
+ value Z_DEFAULT_STRATEGY for normal data, Z_FILTERED for data produced by a
+ filter (or predictor), Z_HUFFMAN_ONLY to force Huffman encoding only (no
+ string match), or Z_RLE to limit match distances to one (run-length
+ encoding). Filtered data consists mostly of small values with a somewhat
+ random distribution. In this case, the compression algorithm is tuned to
+ compress them better. The effect of Z_FILTERED is to force more Huffman
+ coding and less string matching; it is somewhat intermediate between
+ Z_DEFAULT and Z_HUFFMAN_ONLY. Z_RLE is designed to be almost as fast as
+ Z_HUFFMAN_ONLY, but give better compression for PNG image data. The strategy
+ parameter only affects the compression ratio but not the correctness of the
+ compressed output even if it is not set appropriately. Z_FIXED prevents the
+ use of dynamic Huffman codes, allowing for a simpler decoder for special
+ applications.
+
+ deflateInit2 returns Z_OK if success, Z_MEM_ERROR if there was not enough
+ memory, Z_STREAM_ERROR if a parameter is invalid (such as an invalid
+ method). msg is set to null if there is no error message. deflateInit2 does
+ not perform any compression: this will be done by deflate().
+*/
+
+ZEXTERN int ZEXPORT deflateSetDictionary OF((z_streamp strm,
+ const Bytef *dictionary,
+ uInt dictLength));
+/*
+ Initializes the compression dictionary from the given byte sequence
+ without producing any compressed output. This function must be called
+ immediately after deflateInit, deflateInit2 or deflateReset, before any
+ call of deflate. The compressor and decompressor must use exactly the same
+ dictionary (see inflateSetDictionary).
+
+ The dictionary should consist of strings (byte sequences) that are likely
+ to be encountered later in the data to be compressed, with the most commonly
+ used strings preferably put towards the end of the dictionary. Using a
+ dictionary is most useful when the data to be compressed is short and can be
+ predicted with good accuracy; the data can then be compressed better than
+ with the default empty dictionary.
+
+ Depending on the size of the compression data structures selected by
+ deflateInit or deflateInit2, a part of the dictionary may in effect be
+ discarded, for example if the dictionary is larger than the window size in
+ deflate or deflate2. Thus the strings most likely to be useful should be
+ put at the end of the dictionary, not at the front. In addition, the
+ current implementation of deflate will use at most the window size minus
+ 262 bytes of the provided dictionary.
+
+ Upon return of this function, strm->adler is set to the adler32 value
+ of the dictionary; the decompressor may later use this value to determine
+ which dictionary has been used by the compressor. (The adler32 value
+ applies to the whole dictionary even if only a subset of the dictionary is
+ actually used by the compressor.) If a raw deflate was requested, then the
+ adler32 value is not computed and strm->adler is not set.
+
+ deflateSetDictionary returns Z_OK if success, or Z_STREAM_ERROR if a
+ parameter is invalid (such as NULL dictionary) or the stream state is
+ inconsistent (for example if deflate has already been called for this stream
+ or if the compression method is bsort). deflateSetDictionary does not
+ perform any compression: this will be done by deflate().
+*/
+
+ZEXTERN int ZEXPORT deflateCopy OF((z_streamp dest,
+ z_streamp source));
+/*
+ Sets the destination stream as a complete copy of the source stream.
+
+ This function can be useful when several compression strategies will be
+ tried, for example when there are several ways of pre-processing the input
+ data with a filter. The streams that will be discarded should then be freed
+ by calling deflateEnd. Note that deflateCopy duplicates the internal
+ compression state which can be quite large, so this strategy is slow and
+ can consume lots of memory.
+
+ deflateCopy returns Z_OK if success, Z_MEM_ERROR if there was not
+ enough memory, Z_STREAM_ERROR if the source stream state was inconsistent
+ (such as zalloc being NULL). msg is left unchanged in both source and
+ destination.
+*/
+
+ZEXTERN int ZEXPORT deflateReset OF((z_streamp strm));
+/*
+ This function is equivalent to deflateEnd followed by deflateInit,
+ but does not free and reallocate all the internal compression state.
+ The stream will keep the same compression level and any other attributes
+ that may have been set by deflateInit2.
+
+ deflateReset returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent (such as zalloc or state being NULL).
+*/
+
+ZEXTERN int ZEXPORT deflateParams OF((z_streamp strm,
+ int level,
+ int strategy));
+/*
+ Dynamically update the compression level and compression strategy. The
+ interpretation of level and strategy is as in deflateInit2. This can be
+ used to switch between compression and straight copy of the input data, or
+ to switch to a different kind of input data requiring a different
+ strategy. If the compression level is changed, the input available so far
+ is compressed with the old level (and may be flushed); the new level will
+ take effect only at the next call of deflate().
+
+ Before the call of deflateParams, the stream state must be set as for
+ a call of deflate(), since the currently available input may have to
+ be compressed and flushed. In particular, strm->avail_out must be non-zero.
+
+ deflateParams returns Z_OK if success, Z_STREAM_ERROR if the source
+ stream state was inconsistent or if a parameter was invalid, Z_BUF_ERROR
+ if strm->avail_out was zero.
+*/
+
+ZEXTERN int ZEXPORT deflateTune OF((z_streamp strm,
+ int good_length,
+ int max_lazy,
+ int nice_length,
+ int max_chain));
+/*
+ Fine tune deflate's internal compression parameters. This should only be
+ used by someone who understands the algorithm used by zlib's deflate for
+ searching for the best matching string, and even then only by the most
+ fanatic optimizer trying to squeeze out the last compressed bit for their
+ specific input data. Read the deflate.c source code for the meaning of the
+ max_lazy, good_length, nice_length, and max_chain parameters.
+
+ deflateTune() can be called after deflateInit() or deflateInit2(), and
+ returns Z_OK on success, or Z_STREAM_ERROR for an invalid deflate stream.
+ */
+
+ZEXTERN uLong ZEXPORT deflateBound OF((z_streamp strm,
+ uLong sourceLen));
+/*
+ deflateBound() returns an upper bound on the compressed size after
+ deflation of sourceLen bytes. It must be called after deflateInit()
+ or deflateInit2(). This would be used to allocate an output buffer
+ for deflation in a single pass, and so would be called before deflate().
+*/
+
+ZEXTERN int ZEXPORT deflatePrime OF((z_streamp strm,
+ int bits,
+ int value));
+/*
+ deflatePrime() inserts bits in the deflate output stream. The intent
+ is that this function is used to start off the deflate output with the
+ bits leftover from a previous deflate stream when appending to it. As such,
+ this function can only be used for raw deflate, and must be used before the
+ first deflate() call after a deflateInit2() or deflateReset(). bits must be
+ less than or equal to 16, and that many of the least significant bits of
+ value will be inserted in the output.
+
+ deflatePrime returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent.
+*/
+
+ZEXTERN int ZEXPORT deflateSetHeader OF((z_streamp strm,
+ gz_headerp head));
+/*
+ deflateSetHeader() provides gzip header information for when a gzip
+ stream is requested by deflateInit2(). deflateSetHeader() may be called
+ after deflateInit2() or deflateReset() and before the first call of
+ deflate(). The text, time, os, extra field, name, and comment information
+ in the provided gz_header structure are written to the gzip header (xflag is
+ ignored -- the extra flags are set according to the compression level). The
+ caller must assure that, if not Z_NULL, name and comment are terminated with
+ a zero byte, and that if extra is not Z_NULL, that extra_len bytes are
+ available there. If hcrc is true, a gzip header crc is included. Note that
+ the current versions of the command-line version of gzip (up through version
+ 1.3.x) do not support header crc's, and will report that it is a "multi-part
+ gzip file" and give up.
+
+ If deflateSetHeader is not used, the default gzip header has text false,
+ the time set to zero, and os set to 255, with no extra, name, or comment
+ fields. The gzip header is returned to the default state by deflateReset().
+
+ deflateSetHeader returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent.
+*/
+
+/*
+ZEXTERN int ZEXPORT inflateInit2 OF((z_streamp strm,
+ int windowBits));
+
+ This is another version of inflateInit with an extra parameter. The
+ fields next_in, avail_in, zalloc, zfree and opaque must be initialized
+ before by the caller.
+
+ The windowBits parameter is the base two logarithm of the maximum window
+ size (the size of the history buffer). It should be in the range 8..15 for
+ this version of the library. The default value is 15 if inflateInit is used
+ instead. windowBits must be greater than or equal to the windowBits value
+ provided to deflateInit2() while compressing, or it must be equal to 15 if
+ deflateInit2() was not used. If a compressed stream with a larger window
+ size is given as input, inflate() will return with the error code
+ Z_DATA_ERROR instead of trying to allocate a larger window.
+
+ windowBits can also be -8..-15 for raw inflate. In this case, -windowBits
+ determines the window size. inflate() will then process raw deflate data,
+ not looking for a zlib or gzip header, not generating a check value, and not
+ looking for any check values for comparison at the end of the stream. This
+ is for use with other formats that use the deflate compressed data format
+ such as zip. Those formats provide their own check values. If a custom
+ format is developed using the raw deflate format for compressed data, it is
+ recommended that a check value such as an adler32 or a crc32 be applied to
+ the uncompressed data as is done in the zlib, gzip, and zip formats. For
+ most applications, the zlib format should be used as is. Note that comments
+ above on the use in deflateInit2() applies to the magnitude of windowBits.
+
+ windowBits can also be greater than 15 for optional gzip decoding. Add
+ 32 to windowBits to enable zlib and gzip decoding with automatic header
+ detection, or add 16 to decode only the gzip format (the zlib format will
+ return a Z_DATA_ERROR). If a gzip stream is being decoded, strm->adler is
+ a crc32 instead of an adler32.
+
+ inflateInit2 returns Z_OK if success, Z_MEM_ERROR if there was not enough
+ memory, Z_STREAM_ERROR if a parameter is invalid (such as a null strm). msg
+ is set to null if there is no error message. inflateInit2 does not perform
+ any decompression apart from reading the zlib header if present: this will
+ be done by inflate(). (So next_in and avail_in may be modified, but next_out
+ and avail_out are unchanged.)
+*/
+
+ZEXTERN int ZEXPORT inflateSetDictionary OF((z_streamp strm,
+ const Bytef *dictionary,
+ uInt dictLength));
+/*
+ Initializes the decompression dictionary from the given uncompressed byte
+ sequence. This function must be called immediately after a call of inflate,
+ if that call returned Z_NEED_DICT. The dictionary chosen by the compressor
+ can be determined from the adler32 value returned by that call of inflate.
+ The compressor and decompressor must use exactly the same dictionary (see
+ deflateSetDictionary). For raw inflate, this function can be called
+ immediately after inflateInit2() or inflateReset() and before any call of
+ inflate() to set the dictionary. The application must insure that the
+ dictionary that was used for compression is provided.
+
+ inflateSetDictionary returns Z_OK if success, Z_STREAM_ERROR if a
+ parameter is invalid (such as NULL dictionary) or the stream state is
+ inconsistent, Z_DATA_ERROR if the given dictionary doesn't match the
+ expected one (incorrect adler32 value). inflateSetDictionary does not
+ perform any decompression: this will be done by subsequent calls of
+ inflate().
+*/
+
+ZEXTERN int ZEXPORT inflateSync OF((z_streamp strm));
+/*
+ Skips invalid compressed data until a full flush point (see above the
+ description of deflate with Z_FULL_FLUSH) can be found, or until all
+ available input is skipped. No output is provided.
+
+ inflateSync returns Z_OK if a full flush point has been found, Z_BUF_ERROR
+ if no more input was provided, Z_DATA_ERROR if no flush point has been found,
+ or Z_STREAM_ERROR if the stream structure was inconsistent. In the success
+ case, the application may save the current current value of total_in which
+ indicates where valid compressed data was found. In the error case, the
+ application may repeatedly call inflateSync, providing more input each time,
+ until success or end of the input data.
+*/
+
+ZEXTERN int ZEXPORT inflateCopy OF((z_streamp dest,
+ z_streamp source));
+/*
+ Sets the destination stream as a complete copy of the source stream.
+
+ This function can be useful when randomly accessing a large stream. The
+ first pass through the stream can periodically record the inflate state,
+ allowing restarting inflate at those points when randomly accessing the
+ stream.
+
+ inflateCopy returns Z_OK if success, Z_MEM_ERROR if there was not
+ enough memory, Z_STREAM_ERROR if the source stream state was inconsistent
+ (such as zalloc being NULL). msg is left unchanged in both source and
+ destination.
+*/
+
+ZEXTERN int ZEXPORT inflateReset OF((z_streamp strm));
+/*
+ This function is equivalent to inflateEnd followed by inflateInit,
+ but does not free and reallocate all the internal decompression state.
+ The stream will keep attributes that may have been set by inflateInit2.
+
+ inflateReset returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent (such as zalloc or state being NULL).
+*/
+
+ZEXTERN int ZEXPORT inflatePrime OF((z_streamp strm,
+ int bits,
+ int value));
+/*
+ This function inserts bits in the inflate input stream. The intent is
+ that this function is used to start inflating at a bit position in the
+ middle of a byte. The provided bits will be used before any bytes are used
+ from next_in. This function should only be used with raw inflate, and
+ should be used before the first inflate() call after inflateInit2() or
+ inflateReset(). bits must be less than or equal to 16, and that many of the
+ least significant bits of value will be inserted in the input.
+
+ inflatePrime returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent.
+*/
+
+ZEXTERN int ZEXPORT inflateGetHeader OF((z_streamp strm,
+ gz_headerp head));
+/*
+ inflateGetHeader() requests that gzip header information be stored in the
+ provided gz_header structure. inflateGetHeader() may be called after
+ inflateInit2() or inflateReset(), and before the first call of inflate().
+ As inflate() processes the gzip stream, head->done is zero until the header
+ is completed, at which time head->done is set to one. If a zlib stream is
+ being decoded, then head->done is set to -1 to indicate that there will be
+ no gzip header information forthcoming. Note that Z_BLOCK can be used to
+ force inflate() to return immediately after header processing is complete
+ and before any actual data is decompressed.
+
+ The text, time, xflags, and os fields are filled in with the gzip header
+ contents. hcrc is set to true if there is a header CRC. (The header CRC
+ was valid if done is set to one.) If extra is not Z_NULL, then extra_max
+ contains the maximum number of bytes to write to extra. Once done is true,
+ extra_len contains the actual extra field length, and extra contains the
+ extra field, or that field truncated if extra_max is less than extra_len.
+ If name is not Z_NULL, then up to name_max characters are written there,
+ terminated with a zero unless the length is greater than name_max. If
+ comment is not Z_NULL, then up to comm_max characters are written there,
+ terminated with a zero unless the length is greater than comm_max. When
+ any of extra, name, or comment are not Z_NULL and the respective field is
+ not present in the header, then that field is set to Z_NULL to signal its
+ absence. This allows the use of deflateSetHeader() with the returned
+ structure to duplicate the header. However if those fields are set to
+ allocated memory, then the application will need to save those pointers
+ elsewhere so that they can be eventually freed.
+
+ If inflateGetHeader is not used, then the header information is simply
+ discarded. The header is always checked for validity, including the header
+ CRC if present. inflateReset() will reset the process to discard the header
+ information. The application would need to call inflateGetHeader() again to
+ retrieve the header from the next gzip stream.
+
+ inflateGetHeader returns Z_OK if success, or Z_STREAM_ERROR if the source
+ stream state was inconsistent.
+*/
+
+/*
+ZEXTERN int ZEXPORT inflateBackInit OF((z_streamp strm, int windowBits,
+ unsigned char FAR *window));
+
+ Initialize the internal stream state for decompression using inflateBack()
+ calls. The fields zalloc, zfree and opaque in strm must be initialized
+ before the call. If zalloc and zfree are Z_NULL, then the default library-
+ derived memory allocation routines are used. windowBits is the base two
+ logarithm of the window size, in the range 8..15. window is a caller
+ supplied buffer of that size. Except for special applications where it is
+ assured that deflate was used with small window sizes, windowBits must be 15
+ and a 32K byte window must be supplied to be able to decompress general
+ deflate streams.
+
+ See inflateBack() for the usage of these routines.
+
+ inflateBackInit will return Z_OK on success, Z_STREAM_ERROR if any of
+ the paramaters are invalid, Z_MEM_ERROR if the internal state could not
+ be allocated, or Z_VERSION_ERROR if the version of the library does not
+ match the version of the header file.
+*/
+
+typedef unsigned (*in_func) OF((void FAR *, unsigned char FAR * FAR *));
+typedef int (*out_func) OF((void FAR *, unsigned char FAR *, unsigned));
+
+ZEXTERN int ZEXPORT inflateBack OF((z_streamp strm,
+ in_func in, void FAR *in_desc,
+ out_func out, void FAR *out_desc));
+/*
+ inflateBack() does a raw inflate with a single call using a call-back
+ interface for input and output. This is more efficient than inflate() for
+ file i/o applications in that it avoids copying between the output and the
+ sliding window by simply making the window itself the output buffer. This
+ function trusts the application to not change the output buffer passed by
+ the output function, at least until inflateBack() returns.
+
+ inflateBackInit() must be called first to allocate the internal state
+ and to initialize the state with the user-provided window buffer.
+ inflateBack() may then be used multiple times to inflate a complete, raw
+ deflate stream with each call. inflateBackEnd() is then called to free
+ the allocated state.
+
+ A raw deflate stream is one with no zlib or gzip header or trailer.
+ This routine would normally be used in a utility that reads zip or gzip
+ files and writes out uncompressed files. The utility would decode the
+ header and process the trailer on its own, hence this routine expects
+ only the raw deflate stream to decompress. This is different from the
+ normal behavior of inflate(), which expects either a zlib or gzip header and
+ trailer around the deflate stream.
+
+ inflateBack() uses two subroutines supplied by the caller that are then
+ called by inflateBack() for input and output. inflateBack() calls those
+ routines until it reads a complete deflate stream and writes out all of the
+ uncompressed data, or until it encounters an error. The function's
+ parameters and return types are defined above in the in_func and out_func
+ typedefs. inflateBack() will call in(in_desc, &buf) which should return the
+ number of bytes of provided input, and a pointer to that input in buf. If
+ there is no input available, in() must return zero--buf is ignored in that
+ case--and inflateBack() will return a buffer error. inflateBack() will call
+ out(out_desc, buf, len) to write the uncompressed data buf[0..len-1]. out()
+ should return zero on success, or non-zero on failure. If out() returns
+ non-zero, inflateBack() will return with an error. Neither in() nor out()
+ are permitted to change the contents of the window provided to
+ inflateBackInit(), which is also the buffer that out() uses to write from.
+ The length written by out() will be at most the window size. Any non-zero
+ amount of input may be provided by in().
+
+ For convenience, inflateBack() can be provided input on the first call by
+ setting strm->next_in and strm->avail_in. If that input is exhausted, then
+ in() will be called. Therefore strm->next_in must be initialized before
+ calling inflateBack(). If strm->next_in is Z_NULL, then in() will be called
+ immediately for input. If strm->next_in is not Z_NULL, then strm->avail_in
+ must also be initialized, and then if strm->avail_in is not zero, input will
+ initially be taken from strm->next_in[0 .. strm->avail_in - 1].
+
+ The in_desc and out_desc parameters of inflateBack() is passed as the
+ first parameter of in() and out() respectively when they are called. These
+ descriptors can be optionally used to pass any information that the caller-
+ supplied in() and out() functions need to do their job.
+
+ On return, inflateBack() will set strm->next_in and strm->avail_in to
+ pass back any unused input that was provided by the last in() call. The
+ return values of inflateBack() can be Z_STREAM_END on success, Z_BUF_ERROR
+ if in() or out() returned an error, Z_DATA_ERROR if there was a format
+ error in the deflate stream (in which case strm->msg is set to indicate the
+ nature of the error), or Z_STREAM_ERROR if the stream was not properly
+ initialized. In the case of Z_BUF_ERROR, an input or output error can be
+ distinguished using strm->next_in which will be Z_NULL only if in() returned
+ an error. If strm->next is not Z_NULL, then the Z_BUF_ERROR was due to
+ out() returning non-zero. (in() will always be called before out(), so
+ strm->next_in is assured to be defined if out() returns non-zero.) Note
+ that inflateBack() cannot return Z_OK.
+*/
+
+ZEXTERN int ZEXPORT inflateBackEnd OF((z_streamp strm));
+/*
+ All memory allocated by inflateBackInit() is freed.
+
+ inflateBackEnd() returns Z_OK on success, or Z_STREAM_ERROR if the stream
+ state was inconsistent.
+*/
+
+ZEXTERN uLong ZEXPORT zlibCompileFlags OF((void));
+/* Return flags indicating compile-time options.
+
+ Type sizes, two bits each, 00 = 16 bits, 01 = 32, 10 = 64, 11 = other:
+ 1.0: size of uInt
+ 3.2: size of uLong
+ 5.4: size of voidpf (pointer)
+ 7.6: size of z_off_t
+
+ Compiler, assembler, and debug options:
+ 8: DEBUG
+ 9: ASMV or ASMINF -- use ASM code
+ 10: ZLIB_WINAPI -- exported functions use the WINAPI calling convention
+ 11: 0 (reserved)
+
+ One-time table building (smaller code, but not thread-safe if true):
+ 12: BUILDFIXED -- build static block decoding tables when needed
+ 13: DYNAMIC_CRC_TABLE -- build CRC calculation tables when needed
+ 14,15: 0 (reserved)
+
+ Library content (indicates missing functionality):
+ 16: NO_GZCOMPRESS -- gz* functions cannot compress (to avoid linking
+ deflate code when not needed)
+ 17: NO_GZIP -- deflate can't write gzip streams, and inflate can't detect
+ and decode gzip streams (to avoid linking crc code)
+ 18-19: 0 (reserved)
+
+ Operation variations (changes in library functionality):
+ 20: PKZIP_BUG_WORKAROUND -- slightly more permissive inflate
+ 21: FASTEST -- deflate algorithm with only one, lowest compression level
+ 22,23: 0 (reserved)
+
+ The sprintf variant used by gzprintf (zero is best):
+ 24: 0 = vs*, 1 = s* -- 1 means limited to 20 arguments after the format
+ 25: 0 = *nprintf, 1 = *printf -- 1 means gzprintf() not secure!
+ 26: 0 = returns value, 1 = void -- 1 means inferred string length returned
+
+ Remainder:
+ 27-31: 0 (reserved)
+ */
+
+
+ /* utility functions */
+
+/*
+ The following utility functions are implemented on top of the
+ basic stream-oriented functions. To simplify the interface, some
+ default options are assumed (compression level and memory usage,
+ standard memory allocation functions). The source code of these
+ utility functions can easily be modified if you need special options.
+*/
+
+ZEXTERN int ZEXPORT compress OF((Bytef *dest, uLongf *destLen,
+ const Bytef *source, uLong sourceLen));
+/*
+ Compresses the source buffer into the destination buffer. sourceLen is
+ the byte length of the source buffer. Upon entry, destLen is the total
+ size of the destination buffer, which must be at least the value returned
+ by compressBound(sourceLen). Upon exit, destLen is the actual size of the
+ compressed buffer.
+ This function can be used to compress a whole file at once if the
+ input file is mmap'ed.
+ compress returns Z_OK if success, Z_MEM_ERROR if there was not
+ enough memory, Z_BUF_ERROR if there was not enough room in the output
+ buffer.
+*/
+
+ZEXTERN int ZEXPORT compress2 OF((Bytef *dest, uLongf *destLen,
+ const Bytef *source, uLong sourceLen,
+ int level));
+/*
+ Compresses the source buffer into the destination buffer. The level
+ parameter has the same meaning as in deflateInit. sourceLen is the byte
+ length of the source buffer. Upon entry, destLen is the total size of the
+ destination buffer, which must be at least the value returned by
+ compressBound(sourceLen). Upon exit, destLen is the actual size of the
+ compressed buffer.
+
+ compress2 returns Z_OK if success, Z_MEM_ERROR if there was not enough
+ memory, Z_BUF_ERROR if there was not enough room in the output buffer,
+ Z_STREAM_ERROR if the level parameter is invalid.
+*/
+
+ZEXTERN uLong ZEXPORT compressBound OF((uLong sourceLen));
+/*
+ compressBound() returns an upper bound on the compressed size after
+ compress() or compress2() on sourceLen bytes. It would be used before
+ a compress() or compress2() call to allocate the destination buffer.
+*/
+
+ZEXTERN int ZEXPORT uncompress OF((Bytef *dest, uLongf *destLen,
+ const Bytef *source, uLong sourceLen));
+/*
+ Decompresses the source buffer into the destination buffer. sourceLen is
+ the byte length of the source buffer. Upon entry, destLen is the total
+ size of the destination buffer, which must be large enough to hold the
+ entire uncompressed data. (The size of the uncompressed data must have
+ been saved previously by the compressor and transmitted to the decompressor
+ by some mechanism outside the scope of this compression library.)
+ Upon exit, destLen is the actual size of the compressed buffer.
+ This function can be used to decompress a whole file at once if the
+ input file is mmap'ed.
+
+ uncompress returns Z_OK if success, Z_MEM_ERROR if there was not
+ enough memory, Z_BUF_ERROR if there was not enough room in the output
+ buffer, or Z_DATA_ERROR if the input data was corrupted or incomplete.
+*/
+
+
+typedef voidp gzFile;
+
+ZEXTERN gzFile ZEXPORT gzopen OF((const char *path, const char *mode));
+/*
+ Opens a gzip (.gz) file for reading or writing. The mode parameter
+ is as in fopen ("rb" or "wb") but can also include a compression level
+ ("wb9") or a strategy: 'f' for filtered data as in "wb6f", 'h' for
+ Huffman only compression as in "wb1h", or 'R' for run-length encoding
+ as in "wb1R". (See the description of deflateInit2 for more information
+ about the strategy parameter.)
+
+ gzopen can be used to read a file which is not in gzip format; in this
+ case gzread will directly read from the file without decompression.
+
+ gzopen returns NULL if the file could not be opened or if there was
+ insufficient memory to allocate the (de)compression state; errno
+ can be checked to distinguish the two cases (if errno is zero, the
+ zlib error is Z_MEM_ERROR). */
+
+ZEXTERN gzFile ZEXPORT gzdopen OF((int fd, const char *mode));
+/*
+ gzdopen() associates a gzFile with the file descriptor fd. File
+ descriptors are obtained from calls like open, dup, creat, pipe or
+ fileno (in the file has been previously opened with fopen).
+ The mode parameter is as in gzopen.
+ The next call of gzclose on the returned gzFile will also close the
+ file descriptor fd, just like fclose(fdopen(fd), mode) closes the file
+ descriptor fd. If you want to keep fd open, use gzdopen(dup(fd), mode).
+ gzdopen returns NULL if there was insufficient memory to allocate
+ the (de)compression state.
+*/
+
+ZEXTERN int ZEXPORT gzsetparams OF((gzFile file, int level, int strategy));
+/*
+ Dynamically update the compression level or strategy. See the description
+ of deflateInit2 for the meaning of these parameters.
+ gzsetparams returns Z_OK if success, or Z_STREAM_ERROR if the file was not
+ opened for writing.
+*/
+
+ZEXTERN int ZEXPORT gzread OF((gzFile file, voidp buf, unsigned len));
+/*
+ Reads the given number of uncompressed bytes from the compressed file.
+ If the input file was not in gzip format, gzread copies the given number
+ of bytes into the buffer.
+ gzread returns the number of uncompressed bytes actually read (0 for
+ end of file, -1 for error). */
+
+ZEXTERN int ZEXPORT gzwrite OF((gzFile file,
+ voidpc buf, unsigned len));
+/*
+ Writes the given number of uncompressed bytes into the compressed file.
+ gzwrite returns the number of uncompressed bytes actually written
+ (0 in case of error).
+*/
+
+ZEXTERN int ZEXPORTVA gzprintf OF((gzFile file, const char *format, ...));
+/*
+ Converts, formats, and writes the args to the compressed file under
+ control of the format string, as in fprintf. gzprintf returns the number of
+ uncompressed bytes actually written (0 in case of error). The number of
+ uncompressed bytes written is limited to 4095. The caller should assure that
+ this limit is not exceeded. If it is exceeded, then gzprintf() will return
+ return an error (0) with nothing written. In this case, there may also be a
+ buffer overflow with unpredictable consequences, which is possible only if
+ zlib was compiled with the insecure functions sprintf() or vsprintf()
+ because the secure snprintf() or vsnprintf() functions were not available.
+*/
+
+ZEXTERN int ZEXPORT gzputs OF((gzFile file, const char *s));
+/*
+ Writes the given null-terminated string to the compressed file, excluding
+ the terminating null character.
+ gzputs returns the number of characters written, or -1 in case of error.
+*/
+
+ZEXTERN char * ZEXPORT gzgets OF((gzFile file, char *buf, int len));
+/*
+ Reads bytes from the compressed file until len-1 characters are read, or
+ a newline character is read and transferred to buf, or an end-of-file
+ condition is encountered. The string is then terminated with a null
+ character.
+ gzgets returns buf, or Z_NULL in case of error.
+*/
+
+ZEXTERN int ZEXPORT gzputc OF((gzFile file, int c));
+/*
+ Writes c, converted to an unsigned char, into the compressed file.
+ gzputc returns the value that was written, or -1 in case of error.
+*/
+
+ZEXTERN int ZEXPORT gzgetc OF((gzFile file));
+/*
+ Reads one byte from the compressed file. gzgetc returns this byte
+ or -1 in case of end of file or error.
+*/
+
+ZEXTERN int ZEXPORT gzungetc OF((int c, gzFile file));
+/*
+ Push one character back onto the stream to be read again later.
+ Only one character of push-back is allowed. gzungetc() returns the
+ character pushed, or -1 on failure. gzungetc() will fail if a
+ character has been pushed but not read yet, or if c is -1. The pushed
+ character will be discarded if the stream is repositioned with gzseek()
+ or gzrewind().
+*/
+
+ZEXTERN int ZEXPORT gzflush OF((gzFile file, int flush));
+/*
+ Flushes all pending output into the compressed file. The parameter
+ flush is as in the deflate() function. The return value is the zlib
+ error number (see function gzerror below). gzflush returns Z_OK if
+ the flush parameter is Z_FINISH and all output could be flushed.
+ gzflush should be called only when strictly necessary because it can
+ degrade compression.
+*/
+
+ZEXTERN z_off_t ZEXPORT gzseek OF((gzFile file,
+ z_off_t offset, int whence));
+/*
+ Sets the starting position for the next gzread or gzwrite on the
+ given compressed file. The offset represents a number of bytes in the
+ uncompressed data stream. The whence parameter is defined as in lseek(2);
+ the value SEEK_END is not supported.
+ If the file is opened for reading, this function is emulated but can be
+ extremely slow. If the file is opened for writing, only forward seeks are
+ supported; gzseek then compresses a sequence of zeroes up to the new
+ starting position.
+
+ gzseek returns the resulting offset location as measured in bytes from
+ the beginning of the uncompressed stream, or -1 in case of error, in
+ particular if the file is opened for writing and the new starting position
+ would be before the current position.
+*/
+
+ZEXTERN int ZEXPORT gzrewind OF((gzFile file));
+/*
+ Rewinds the given file. This function is supported only for reading.
+
+ gzrewind(file) is equivalent to (int)gzseek(file, 0L, SEEK_SET)
+*/
+
+ZEXTERN z_off_t ZEXPORT gztell OF((gzFile file));
+/*
+ Returns the starting position for the next gzread or gzwrite on the
+ given compressed file. This position represents a number of bytes in the
+ uncompressed data stream.
+
+ gztell(file) is equivalent to gzseek(file, 0L, SEEK_CUR)
+*/
+
+ZEXTERN int ZEXPORT gzeof OF((gzFile file));
+/*
+ Returns 1 when EOF has previously been detected reading the given
+ input stream, otherwise zero.
+*/
+
+ZEXTERN int ZEXPORT gzdirect OF((gzFile file));
+/*
+ Returns 1 if file is being read directly without decompression, otherwise
+ zero.
+*/
+
+ZEXTERN int ZEXPORT gzclose OF((gzFile file));
+/*
+ Flushes all pending output if necessary, closes the compressed file
+ and deallocates all the (de)compression state. The return value is the zlib
+ error number (see function gzerror below).
+*/
+
+ZEXTERN const char * ZEXPORT gzerror OF((gzFile file, int *errnum));
+/*
+ Returns the error message for the last error which occurred on the
+ given compressed file. errnum is set to zlib error number. If an
+ error occurred in the file system and not in the compression library,
+ errnum is set to Z_ERRNO and the application may consult errno
+ to get the exact error code.
+*/
+
+ZEXTERN void ZEXPORT gzclearerr OF((gzFile file));
+/*
+ Clears the error and end-of-file flags for file. This is analogous to the
+ clearerr() function in stdio. This is useful for continuing to read a gzip
+ file that is being written concurrently.
+*/
+
+ /* checksum functions */
+
+/*
+ These functions are not related to compression but are exported
+ anyway because they might be useful in applications using the
+ compression library.
+*/
+
+ZEXTERN uLong ZEXPORT adler32 OF((uLong adler, const Bytef *buf, uInt len));
+/*
+ Update a running Adler-32 checksum with the bytes buf[0..len-1] and
+ return the updated checksum. If buf is NULL, this function returns
+ the required initial value for the checksum.
+ An Adler-32 checksum is almost as reliable as a CRC32 but can be computed
+ much faster. Usage example:
+
+ uLong adler = adler32(0L, Z_NULL, 0);
+
+ while (read_buffer(buffer, length) != EOF) {
+ adler = adler32(adler, buffer, length);
+ }
+ if (adler != original_adler) error();
+*/
+
+ZEXTERN uLong ZEXPORT adler32_combine OF((uLong adler1, uLong adler2,
+ z_off_t len2));
+/*
+ Combine two Adler-32 checksums into one. For two sequences of bytes, seq1
+ and seq2 with lengths len1 and len2, Adler-32 checksums were calculated for
+ each, adler1 and adler2. adler32_combine() returns the Adler-32 checksum of
+ seq1 and seq2 concatenated, requiring only adler1, adler2, and len2.
+*/
+
+ZEXTERN uLong ZEXPORT crc32 OF((uLong crc, const Bytef *buf, uInt len));
+/*
+ Update a running CRC-32 with the bytes buf[0..len-1] and return the
+ updated CRC-32. If buf is NULL, this function returns the required initial
+ value for the for the crc. Pre- and post-conditioning (one's complement) is
+ performed within this function so it shouldn't be done by the application.
+ Usage example:
+
+ uLong crc = crc32(0L, Z_NULL, 0);
+
+ while (read_buffer(buffer, length) != EOF) {
+ crc = crc32(crc, buffer, length);
+ }
+ if (crc != original_crc) error();
+*/
+
+ZEXTERN uLong ZEXPORT crc32_combine OF((uLong crc1, uLong crc2, z_off_t len2));
+
+/*
+ Combine two CRC-32 check values into one. For two sequences of bytes,
+ seq1 and seq2 with lengths len1 and len2, CRC-32 check values were
+ calculated for each, crc1 and crc2. crc32_combine() returns the CRC-32
+ check value of seq1 and seq2 concatenated, requiring only crc1, crc2, and
+ len2.
+*/
+
+
+ /* various hacks, don't look :) */
+
+/* deflateInit and inflateInit are macros to allow checking the zlib version
+ * and the compiler's view of z_stream:
+ */
+ZEXTERN int ZEXPORT deflateInit_ OF((z_streamp strm, int level,
+ const char *version, int stream_size));
+ZEXTERN int ZEXPORT inflateInit_ OF((z_streamp strm,
+ const char *version, int stream_size));
+ZEXTERN int ZEXPORT deflateInit2_ OF((z_streamp strm, int level, int method,
+ int windowBits, int memLevel,
+ int strategy, const char *version,
+ int stream_size));
+ZEXTERN int ZEXPORT inflateInit2_ OF((z_streamp strm, int windowBits,
+ const char *version, int stream_size));
+ZEXTERN int ZEXPORT inflateBackInit_ OF((z_streamp strm, int windowBits,
+ unsigned char FAR *window,
+ const char *version,
+ int stream_size));
+#define deflateInit(strm, level) \
+ deflateInit_((strm), (level), ZLIB_VERSION, sizeof(z_stream))
+#define inflateInit(strm) \
+ inflateInit_((strm), ZLIB_VERSION, sizeof(z_stream))
+#define deflateInit2(strm, level, method, windowBits, memLevel, strategy) \
+ deflateInit2_((strm),(level),(method),(windowBits),(memLevel),\
+ (strategy), ZLIB_VERSION, sizeof(z_stream))
+#define inflateInit2(strm, windowBits) \
+ inflateInit2_((strm), (windowBits), ZLIB_VERSION, sizeof(z_stream))
+#define inflateBackInit(strm, windowBits, window) \
+ inflateBackInit_((strm), (windowBits), (window), \
+ ZLIB_VERSION, sizeof(z_stream))
+
+
+#if !defined(ZUTIL_H) && !defined(NO_DUMMY_DECL)
+ struct internal_state {int dummy;}; /* hack for buggy compilers */
+#endif
+
+ZEXTERN const char * ZEXPORT zError OF((int));
+ZEXTERN int ZEXPORT inflateSyncPoint OF((z_streamp z));
+ZEXTERN const uLongf * ZEXPORT get_crc_table OF((void));
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif /* ZLIB_H */
packager = TDB <email@email.com>
distribution-name = Red Hat Linux
requires = python
+
+[egg_info]
+tag_build =
+tag_date = 0
+tag_svn_revision = 0
+
'''
-import os, sys, glob, shutil, hashlib
+import os, sys, glob, shutil, hashlib, re, fnmatch
+import platform
name = "pysam"
version = version.__version__
-samtools_exclude = ( "bamtk.c", "razip.c", "bgzip.c", "errmod.c", "bam_reheader.c", "bam2bcf.c" )
+samtools_exclude = ( "bamtk.c", "razip.c", "bgzip.c",
+ "bam_reheader.c",
+ "main.c", "calDepth.c", "bam2bed.c",
+ "wgsim.c", "md5fa.c", "maq2sam.c",)
samtools_dest = os.path.abspath( "samtools" )
tabix_exclude = ( "main.c", )
tabix_dest = os.path.abspath( "tabix" )
+def locate(pattern, root=os.curdir):
+ '''Locate all files matching supplied filename pattern in and below
+ supplied root directory.'''
+ for path, dirs, files in os.walk(os.path.abspath(root)):
+ for filename in fnmatch.filter(files, pattern):
+ yield os.path.join(path, filename)
+
+def _update_pysam_files(cf, destdir):
+ for filename in cf:
+ if not filename: continue
+ dest = filename + ".pysam.c"
+ with open( filename ) as infile:
+ with open( dest, "w" ) as outfile:
+ outfile.write( '#include "pysam.h"\n\n' )
+ outfile.write( re.sub( "stderr", "pysamerr", "".join(infile.readlines()) ) )
+ with open( os.path.join( destdir, "pysam.h" ), "w" )as outfile:
+ outfile.write ("""#ifndef PYSAM_H
+#define PYSAM_H
+#include "stdio.h"
+extern FILE * pysamerr;
+#endif
+""")
+
# copy samtools source
if len(sys.argv) >= 2 and sys.argv[1] == "import":
if len(sys.argv) < 3: raise ValueError("missing PATH to samtools source directory")
srcdir = os.path.abspath( srcdir )
if not os.path.exists( srcdir ): raise IOError( "samtools src dir `%s` does not exist." % srcdir )
- cfiles = glob.glob( os.path.join( srcdir, "*.c" ) )
- hfiles = glob.glob( os.path.join( srcdir, "*.h" ) )
+ cfiles = locate( "*.c", srcdir )
+ hfiles = locate( "*.h", srcdir )
ncopied = 0
- for new_file in cfiles + hfiles:
- f = os.path.basename(new_file)
- if f in exclude: continue
- old_file = os.path.join( destdir, f )
+
+ def _compareAndCopy( src, srcdir, destdir, exclude ):
+
+ d, f = os.path.split(src)
+ if f in exclude: return None
+ common_prefix = os.path.commonprefix( (d, srcdir ) )
+ subdir = re.sub( common_prefix, "", d )[1:]
+ targetdir = os.path.join( destdir, subdir )
+ if not os.path.exists( targetdir ):
+ os.makedirs( targetdir )
+ old_file = os.path.join( targetdir, f )
if os.path.exists( old_file ):
md5_old = hashlib.md5("".join(open(old_file,"r").readlines())).digest()
- md5_new = hashlib.md5("".join(open(new_file,"r").readlines())).digest()
- if md5_old == md5_new: continue
- raise ValueError( "incompatible files for %s and %s" % (old_file, new_file ))
+ md5_new = hashlib.md5("".join(open(src,"r").readlines())).digest()
+ if md5_old != md5_new:
+ raise ValueError( "incompatible files for %s and %s" % (old_file, src ))
+
+ shutil.copy( src, targetdir )
+ return old_file
+
+ for src_file in hfiles:
+ _compareAndCopy( src_file, srcdir,destdir, exclude )
+ ncopied += 1
- shutil.copy( new_file, destdir )
+ cf = []
+ for src_file in cfiles:
+ cf.append( _compareAndCopy( src_file, srcdir, destdir, exclude ) )
ncopied += 1
+
print "installed latest source code from %s: %i files copied" % (srcdir, ncopied)
+ # redirect stderr to pysamerr and replace bam.h with a stub.
+ print "applying stderr redirection"
+
+ _update_pysam_files(cf, destdir)
+
+
sys.exit(0)
-from distutils.core import setup, Extension
-from Cython.Distutils import build_ext
+if len(sys.argv) >= 2 and sys.argv[1] == "refresh":
+ print "refreshing latest source code from .c to .pysam.c"
+# redirect stderr to pysamerr and replace bam.h with a stub.
+ print "applying stderr redirection"
+ for destdir in ('samtools', 'tabix'):
+ pysamcfiles = locate( "*.pysam.c", destdir )
+ for f in pysamcfiles: os.remove(f)
+ cfiles = locate( "*.c", destdir )
+ _update_pysam_files(cfiles, destdir)
+
+ sys.exit(0)
+
+
+
+from ez_setup import use_setuptools
+use_setuptools()
+
+from setuptools import Extension, setup
+
+## note that for automatic cythoning,
+## both pyrex and cython need to be installed.
+## see http://mail.python.org/pipermail/distutils-sig/2007-September/008204.html
+
+try:
+ from Cython.Distutils import build_ext
+except:
+ from setuptools.command.build_ext import build_ext
classifiers = """
Development Status :: 2 - Alpha
Topic :: Scientific/Engineering :: Bioinformatics
"""
+if platform.system()=='Windows':
+ include_os = ['win32']
+ os_c_files = ['win32/getopt.c']
+else:
+ include_os = []
+ os_c_files = []
+
samtools = Extension(
"csamtools", # name of extension
[ "pysam/csamtools.pyx" ] +\
- [ "pysam/%s" % x for x in (
- "pysam_util.c", )] +\
- glob.glob( os.path.join( "samtools", "*.c" ) ),
+ [ "pysam/%s" % x for x in (
+ "pysam_util.c", )] +\
+ glob.glob( os.path.join( "samtools", "*.pysam.c" )) +\
+ os_c_files + \
+ glob.glob( os.path.join( "samtools", "*", "*.pysam.c" ) ),
library_dirs=[],
- include_dirs=[ "samtools", "pysam" ],
+ include_dirs=[ "samtools", "pysam" ] + include_os,
libraries=[ "z", ],
language="c",
- define_macros = [('FILE_OFFSET_BITS','64'),
+ define_macros = [('_FILE_OFFSET_BITS','64'),
('_USE_KNETFILE','')],
)
tabix = Extension(
"ctabix", # name of extension
- [ "pysam/ctabix.pyx" ] +\
- [ "pysam/%s" % x for x in ()] +\
- glob.glob( os.path.join( "tabix", "*.c" ) ),
+ [ "pysam/ctabix.pyx", ] +\
+ [ "pysam/%s" % x for x in ( "tabix_util.c", )] +\
+ os_c_files + \
+ glob.glob( os.path.join( "tabix", "*.pysam.c" ) ),
+ library_dirs=[],
+ include_dirs=[ "tabix", "pysam" ] + include_os,
+ libraries=[ "z", ],
+ language="c",
+ )
+
+tabproxies = Extension(
+ "TabProxies", # name of extension
+ [ "pysam/TabProxies.pyx", ] + os_c_files,
+ library_dirs=[],
+ include_dirs= include_os,
+ libraries=[ "z", ],
+ language="c",
+ )
+
+cvcf = Extension(
+ "cvcf", # name of extension
+ [ "pysam/cvcf.pyx", ] + os_c_files,
library_dirs=[],
- include_dirs=[ "tabix", "pysam" ],
+ include_dirs= ["tabix",] + include_os,
libraries=[ "z", ],
language="c",
)
"pysam/Pileup",
"pysam/namedtuple",
"pysam/version" ],
- 'ext_modules': [samtools, tabix],
+ 'requires' : ['cython (>=0.12)'],
+ 'ext_modules': [samtools, tabix, tabproxies, cvcf ],
'cmdclass' : {'build_ext': build_ext},
+ 'install_requires' : ['cython>=0.12.1',],
+ # do not pack in order to permit linking to csamtools.so
+ 'zip_safe' :False,
}
if __name__=='__main__':
--- /dev/null
+#include "pysam.h"
+
+#include <stdlib.h>
+#include <stdint.h>
+#include <string.h>
+#include <stdio.h>
+#include <zlib.h>
+
+#include "ksort.h"
+KSORT_INIT_GENERIC(uint64_t)
+
+#include "kseq.h"
+KSTREAM_INIT(gzFile, gzread, 8192)
+
+typedef struct {
+ int n, m;
+ uint64_t *a;
+ int *idx;
+} bed_reglist_t;
+
+#include "khash.h"
+KHASH_MAP_INIT_STR(reg, bed_reglist_t)
+
+#define LIDX_SHIFT 13
+
+typedef kh_reg_t reghash_t;
+
+int *bed_index_core(int n, uint64_t *a, int *n_idx)
+{
+ int i, j, m, *idx;
+ m = *n_idx = 0; idx = 0;
+ for (i = 0; i < n; ++i) {
+ int beg, end;
+ beg = a[i]>>32 >> LIDX_SHIFT; end = ((uint32_t)a[i]) >> LIDX_SHIFT;
+ if (m < end + 1) {
+ int oldm = m;
+ m = end + 1;
+ kroundup32(m);
+ idx = realloc(idx, m * sizeof(int));
+ for (j = oldm; j < m; ++j) idx[j] = -1;
+ }
+ if (beg == end) {
+ if (idx[beg] < 0) idx[beg] = i;
+ } else {
+ for (j = beg; j <= end; ++j)
+ if (idx[j] < 0) idx[j] = i;
+ }
+ *n_idx = end + 1;
+ }
+ return idx;
+}
+
+void bed_index(void *_h)
+{
+ reghash_t *h = (reghash_t*)_h;
+ khint_t k;
+ for (k = 0; k < kh_end(h); ++k) {
+ if (kh_exist(h, k)) {
+ bed_reglist_t *p = &kh_val(h, k);
+ if (p->idx) free(p->idx);
+ ks_introsort(uint64_t, p->n, p->a);
+ p->idx = bed_index_core(p->n, p->a, &p->m);
+ }
+ }
+}
+
+int bed_overlap_core(const bed_reglist_t *p, int beg, int end)
+{
+ int i, min_off;
+ if (p->n == 0) return 0;
+ min_off = (beg>>LIDX_SHIFT >= p->n)? p->idx[p->n-1] : p->idx[beg>>LIDX_SHIFT];
+ if (min_off < 0) { // TODO: this block can be improved, but speed should not matter too much here
+ int n = beg>>LIDX_SHIFT;
+ if (n > p->n) n = p->n;
+ for (i = n - 1; i >= 0; --i)
+ if (p->idx[i] >= 0) break;
+ min_off = i >= 0? p->idx[i] : 0;
+ }
+ for (i = min_off; i < p->n; ++i) {
+ if ((int)(p->a[i]>>32) >= end) break; // out of range; no need to proceed
+ if ((int32_t)p->a[i] > beg && (int32_t)(p->a[i]>>32) < end)
+ return 1; // find the overlap; return
+ }
+ return 0;
+}
+
+int bed_overlap(const void *_h, const char *chr, int beg, int end)
+{
+ const reghash_t *h = (const reghash_t*)_h;
+ khint_t k;
+ if (!h) return 0;
+ k = kh_get(reg, h, chr);
+ if (k == kh_end(h)) return 0;
+ return bed_overlap_core(&kh_val(h, k), beg, end);
+}
+
+void *bed_read(const char *fn)
+{
+ reghash_t *h = kh_init(reg);
+ gzFile fp;
+ kstream_t *ks;
+ int dret;
+ kstring_t *str;
+ // read the list
+ fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
+ if (fp == 0) return 0;
+ str = calloc(1, sizeof(kstring_t));
+ ks = ks_init(fp);
+ while (ks_getuntil(ks, 0, str, &dret) >= 0) { // read the chr name
+ int beg = -1, end = -1;
+ bed_reglist_t *p;
+ khint_t k = kh_get(reg, h, str->s);
+ if (k == kh_end(h)) { // absent from the hash table
+ int ret;
+ char *s = strdup(str->s);
+ k = kh_put(reg, h, s, &ret);
+ memset(&kh_val(h, k), 0, sizeof(bed_reglist_t));
+ }
+ p = &kh_val(h, k);
+ if (dret != '\n') { // if the lines has other characters
+ if (ks_getuntil(ks, 0, str, &dret) > 0 && isdigit(str->s[0])) {
+ beg = atoi(str->s); // begin
+ if (dret != '\n') {
+ if (ks_getuntil(ks, 0, str, &dret) > 0 && isdigit(str->s[0]))
+ end = atoi(str->s); // end
+ }
+ }
+ }
+ if (dret != '\n') while ((dret = ks_getc(ks)) > 0 && dret != '\n'); // skip the rest of the line
+ if (end < 0 && beg > 0) end = beg, beg = beg - 1; // if there is only one column
+ if (beg >= 0 && end > beg) {
+ if (p->n == p->m) {
+ p->m = p->m? p->m<<1 : 4;
+ p->a = realloc(p->a, p->m * 8);
+ }
+ p->a[p->n++] = (uint64_t)beg<<32 | end;
+ }
+ }
+ ks_destroy(ks);
+ gzclose(fp);
+ free(str->s); free(str);
+ bed_index(h);
+ return h;
+}
+
+void bed_destroy(void *_h)
+{
+ reghash_t *h = (reghash_t*)_h;
+ khint_t k;
+ for (k = 0; k < kh_end(h); ++k) {
+ if (kh_exist(h, k)) {
+ free(kh_val(h, k).a);
+ free(kh_val(h, k).idx);
+ free((char*)kh_key(h, k));
+ }
+ }
+ kh_destroy(reg, h);
+}
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
-
- Permission is hereby granted, free of charge, to any person obtaining a copy
- of this software and associated documentation files (the "Software"), to deal
- in the Software without restriction, including without limitation the rights
- to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
- copies of the Software, and to permit persons to whom the Software is
- furnished to do so, subject to the following conditions:
-
- The above copyright notice and this permission notice shall be included in
- all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
- IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
- FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
- AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
- LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
- OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
- THE SOFTWARE.
-*/
-
-/*
- 2009-06-29 by lh3: cache recent uncompressed blocks.
- 2009-06-25 by lh3: optionally use my knetfile library to access file on a FTP.
- 2009-06-12 by lh3: support a mode string like "wu" where 'u' for uncompressed output */
-
-#include <stdio.h>
-#include <stdlib.h>
-#include <string.h>
-#include <unistd.h>
-#include <fcntl.h>
-#include <sys/types.h>
-#include <sys/stat.h>
-#include "bgzf.h"
-
-#include "khash.h"
-typedef struct {
- int size;
- uint8_t *block;
- int64_t end_offset;
-} cache_t;
-KHASH_MAP_INIT_INT64(cache, cache_t)
-
-#if defined(_WIN32) || defined(_MSC_VER)
-#define ftello(fp) ftell(fp)
-#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
-#else
-extern off_t ftello(FILE *stream);
-extern int fseeko(FILE *stream, off_t offset, int whence);
-#endif
-
-typedef int8_t bgzf_byte_t;
-
-static const int DEFAULT_BLOCK_SIZE = 64 * 1024;
-static const int MAX_BLOCK_SIZE = 64 * 1024;
-
-static const int BLOCK_HEADER_LENGTH = 18;
-static const int BLOCK_FOOTER_LENGTH = 8;
-
-static const int GZIP_ID1 = 31;
-static const int GZIP_ID2 = 139;
-static const int CM_DEFLATE = 8;
-static const int FLG_FEXTRA = 4;
-static const int OS_UNKNOWN = 255;
-static const int BGZF_ID1 = 66; // 'B'
-static const int BGZF_ID2 = 67; // 'C'
-static const int BGZF_LEN = 2;
-static const int BGZF_XLEN = 6; // BGZF_LEN+4
-
-static const int GZIP_WINDOW_BITS = -15; // no zlib header
-static const int Z_DEFAULT_MEM_LEVEL = 8;
-
-
-inline
-void
-packInt16(uint8_t* buffer, uint16_t value)
-{
- buffer[0] = value;
- buffer[1] = value >> 8;
-}
-
-inline
-int
-unpackInt16(const uint8_t* buffer)
-{
- return (buffer[0] | (buffer[1] << 8));
-}
-
-inline
-void
-packInt32(uint8_t* buffer, uint32_t value)
-{
- buffer[0] = value;
- buffer[1] = value >> 8;
- buffer[2] = value >> 16;
- buffer[3] = value >> 24;
-}
-
-static inline
-int
-bgzf_min(int x, int y)
-{
- return (x < y) ? x : y;
-}
-
-static
-void
-report_error(BGZF* fp, const char* message) {
- fp->error = message;
-}
-
-static BGZF *bgzf_read_init()
-{
- BGZF *fp;
- fp = calloc(1, sizeof(BGZF));
- fp->uncompressed_block_size = MAX_BLOCK_SIZE;
- fp->uncompressed_block = malloc(MAX_BLOCK_SIZE);
- fp->compressed_block_size = MAX_BLOCK_SIZE;
- fp->compressed_block = malloc(MAX_BLOCK_SIZE);
- fp->cache_size = 0;
- fp->cache = kh_init(cache);
- return fp;
-}
-
-static
-BGZF*
-open_read(int fd)
-{
-#ifdef _USE_KNETFILE
- knetFile *file = knet_dopen(fd, "r");
-#else
- FILE* file = fdopen(fd, "r");
-#endif
- BGZF* fp;
- if (file == 0) return 0;
- fp = bgzf_read_init();
- fp->file_descriptor = fd;
- fp->open_mode = 'r';
-#ifdef _USE_KNETFILE
- fp->x.fpr = file;
-#else
- fp->file = file;
-#endif
- return fp;
-}
-
-static
-BGZF*
-open_write(int fd, bool is_uncompressed)
-{
- FILE* file = fdopen(fd, "w");
- BGZF* fp;
- if (file == 0) return 0;
- fp = malloc(sizeof(BGZF));
- fp->file_descriptor = fd;
- fp->open_mode = 'w';
- fp->owned_file = 0; fp->is_uncompressed = is_uncompressed;
-#ifdef _USE_KNETFILE
- fp->x.fpw = file;
-#else
- fp->file = file;
-#endif
- fp->uncompressed_block_size = DEFAULT_BLOCK_SIZE;
- fp->uncompressed_block = NULL;
- fp->compressed_block_size = MAX_BLOCK_SIZE;
- fp->compressed_block = malloc(MAX_BLOCK_SIZE);
- fp->block_address = 0;
- fp->block_offset = 0;
- fp->block_length = 0;
- fp->error = NULL;
- return fp;
-}
-
-BGZF*
-bgzf_open(const char* __restrict path, const char* __restrict mode)
-{
- BGZF* fp = NULL;
- if (mode[0] == 'r' || mode[0] == 'R') { /* The reading mode is preferred. */
-#ifdef _USE_KNETFILE
- knetFile *file = knet_open(path, mode);
- if (file == 0) return 0;
- fp = bgzf_read_init();
- fp->file_descriptor = -1;
- fp->open_mode = 'r';
- fp->x.fpr = file;
-#else
- int fd, oflag = O_RDONLY;
-#ifdef _WIN32
- oflag |= O_BINARY;
-#endif
- fd = open(path, oflag);
- if (fd == -1) return 0;
- fp = open_read(fd);
-#endif
- } else if (mode[0] == 'w' || mode[0] == 'W') {
- int fd, oflag = O_WRONLY | O_CREAT | O_TRUNC;
-#ifdef _WIN32
- oflag |= O_BINARY;
-#endif
- fd = open(path, oflag, 0666);
- if (fd == -1) return 0;
- fp = open_write(fd, strstr(mode, "u")? 1 : 0);
- }
- if (fp != NULL) {
- fp->owned_file = 1;
- }
- return fp;
-}
-
-BGZF*
-bgzf_fdopen(int fd, const char * __restrict mode)
-{
- if (fd == -1) return 0;
- if (mode[0] == 'r' || mode[0] == 'R') {
- return open_read(fd);
- } else if (mode[0] == 'w' || mode[0] == 'W') {
- return open_write(fd, strstr(mode, "u")? 1 : 0);
- } else {
- return NULL;
- }
-}
-
-static
-int
-deflate_block(BGZF* fp, int block_length)
-{
- // Deflate the block in fp->uncompressed_block into fp->compressed_block.
- // Also adds an extra field that stores the compressed block length.
-
- bgzf_byte_t* buffer = fp->compressed_block;
- int buffer_size = fp->compressed_block_size;
-
- // Init gzip header
- buffer[0] = GZIP_ID1;
- buffer[1] = GZIP_ID2;
- buffer[2] = CM_DEFLATE;
- buffer[3] = FLG_FEXTRA;
- buffer[4] = 0; // mtime
- buffer[5] = 0;
- buffer[6] = 0;
- buffer[7] = 0;
- buffer[8] = 0;
- buffer[9] = OS_UNKNOWN;
- buffer[10] = BGZF_XLEN;
- buffer[11] = 0;
- buffer[12] = BGZF_ID1;
- buffer[13] = BGZF_ID2;
- buffer[14] = BGZF_LEN;
- buffer[15] = 0;
- buffer[16] = 0; // placeholder for block length
- buffer[17] = 0;
-
- // loop to retry for blocks that do not compress enough
- int input_length = block_length;
- int compressed_length = 0;
- while (1) {
- int compress_level = fp->is_uncompressed? 0 : Z_DEFAULT_COMPRESSION;
- z_stream zs;
- zs.zalloc = NULL;
- zs.zfree = NULL;
- zs.next_in = fp->uncompressed_block;
- zs.avail_in = input_length;
- zs.next_out = (void*)&buffer[BLOCK_HEADER_LENGTH];
- zs.avail_out = buffer_size - BLOCK_HEADER_LENGTH - BLOCK_FOOTER_LENGTH;
-
- int status = deflateInit2(&zs, compress_level, Z_DEFLATED,
- GZIP_WINDOW_BITS, Z_DEFAULT_MEM_LEVEL, Z_DEFAULT_STRATEGY);
- if (status != Z_OK) {
- report_error(fp, "deflate init failed");
- return -1;
- }
- status = deflate(&zs, Z_FINISH);
- if (status != Z_STREAM_END) {
- deflateEnd(&zs);
- if (status == Z_OK) {
- // Not enough space in buffer.
- // Can happen in the rare case the input doesn't compress enough.
- // Reduce the amount of input until it fits.
- input_length -= 1024;
- if (input_length <= 0) {
- // should never happen
- report_error(fp, "input reduction failed");
- return -1;
- }
- continue;
- }
- report_error(fp, "deflate failed");
- return -1;
- }
- status = deflateEnd(&zs);
- if (status != Z_OK) {
- report_error(fp, "deflate end failed");
- return -1;
- }
- compressed_length = zs.total_out;
- compressed_length += BLOCK_HEADER_LENGTH + BLOCK_FOOTER_LENGTH;
- if (compressed_length > MAX_BLOCK_SIZE) {
- // should never happen
- report_error(fp, "deflate overflow");
- return -1;
- }
- break;
- }
-
- packInt16((uint8_t*)&buffer[16], compressed_length-1);
- uint32_t crc = crc32(0L, NULL, 0L);
- crc = crc32(crc, fp->uncompressed_block, input_length);
- packInt32((uint8_t*)&buffer[compressed_length-8], crc);
- packInt32((uint8_t*)&buffer[compressed_length-4], input_length);
-
- int remaining = block_length - input_length;
- if (remaining > 0) {
- if (remaining > input_length) {
- // should never happen (check so we can use memcpy)
- report_error(fp, "remainder too large");
- return -1;
- }
- memcpy(fp->uncompressed_block,
- fp->uncompressed_block + input_length,
- remaining);
- }
- fp->block_offset = remaining;
- return compressed_length;
-}
-
-static
-int
-inflate_block(BGZF* fp, int block_length)
-{
- // Inflate the block in fp->compressed_block into fp->uncompressed_block
-
- z_stream zs;
- zs.zalloc = NULL;
- zs.zfree = NULL;
- zs.next_in = fp->compressed_block + 18;
- zs.avail_in = block_length - 16;
- zs.next_out = fp->uncompressed_block;
- zs.avail_out = fp->uncompressed_block_size;
-
- int status = inflateInit2(&zs, GZIP_WINDOW_BITS);
- if (status != Z_OK) {
- report_error(fp, "inflate init failed");
- return -1;
- }
- status = inflate(&zs, Z_FINISH);
- if (status != Z_STREAM_END) {
- inflateEnd(&zs);
- report_error(fp, "inflate failed");
- return -1;
- }
- status = inflateEnd(&zs);
- if (status != Z_OK) {
- report_error(fp, "inflate failed");
- return -1;
- }
- return zs.total_out;
-}
-
-static
-int
-check_header(const bgzf_byte_t* header)
-{
- return (header[0] == GZIP_ID1 &&
- header[1] == (bgzf_byte_t) GZIP_ID2 &&
- header[2] == Z_DEFLATED &&
- (header[3] & FLG_FEXTRA) != 0 &&
- unpackInt16((uint8_t*)&header[10]) == BGZF_XLEN &&
- header[12] == BGZF_ID1 &&
- header[13] == BGZF_ID2 &&
- unpackInt16((uint8_t*)&header[14]) == BGZF_LEN);
-}
-
-static void free_cache(BGZF *fp)
-{
- khint_t k;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- if (fp->open_mode != 'r') return;
- for (k = kh_begin(h); k < kh_end(h); ++k)
- if (kh_exist(h, k)) free(kh_val(h, k).block);
- kh_destroy(cache, h);
-}
-
-static int load_block_from_cache(BGZF *fp, int64_t block_address)
-{
- khint_t k;
- cache_t *p;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- k = kh_get(cache, h, block_address);
- if (k == kh_end(h)) return 0;
- p = &kh_val(h, k);
- if (fp->block_length != 0) fp->block_offset = 0;
- fp->block_address = block_address;
- fp->block_length = p->size;
- memcpy(fp->uncompressed_block, p->block, MAX_BLOCK_SIZE);
-#ifdef _USE_KNETFILE
- knet_seek(fp->x.fpr, p->end_offset, SEEK_SET);
-#else
- fseeko(fp->file, p->end_offset, SEEK_SET);
-#endif
- return p->size;
-}
-
-static void cache_block(BGZF *fp, int size)
-{
- int ret;
- khint_t k;
- cache_t *p;
- khash_t(cache) *h = (khash_t(cache)*)fp->cache;
- if (MAX_BLOCK_SIZE >= fp->cache_size) return;
- if ((kh_size(h) + 1) * MAX_BLOCK_SIZE > fp->cache_size) {
- /* A better way would be to remove the oldest block in the
- * cache, but here we remove a random one for simplicity. This
- * should not have a big impact on performance. */
- for (k = kh_begin(h); k < kh_end(h); ++k)
- if (kh_exist(h, k)) break;
- if (k < kh_end(h)) {
- free(kh_val(h, k).block);
- kh_del(cache, h, k);
- }
- }
- k = kh_put(cache, h, fp->block_address, &ret);
- if (ret == 0) return; // if this happens, a bug!
- p = &kh_val(h, k);
- p->size = fp->block_length;
- p->end_offset = fp->block_address + size;
- p->block = malloc(MAX_BLOCK_SIZE);
- memcpy(kh_val(h, k).block, fp->uncompressed_block, MAX_BLOCK_SIZE);
-}
-
-int
-bgzf_read_block(BGZF* fp)
-{
- bgzf_byte_t header[BLOCK_HEADER_LENGTH];
- int size = 0;
-#ifdef _USE_KNETFILE
- int64_t block_address = knet_tell(fp->x.fpr);
- if (load_block_from_cache(fp, block_address)) return 0;
- int count = knet_read(fp->x.fpr, header, sizeof(header));
-#else
- int64_t block_address = ftello(fp->file);
- if (load_block_from_cache(fp, block_address)) return 0;
- int count = fread(header, 1, sizeof(header), fp->file);
-#endif
- if (count == 0) {
- fp->block_length = 0;
- return 0;
- }
- size = count;
- if (count != sizeof(header)) {
- report_error(fp, "read failed");
- return -1;
- }
- if (!check_header(header)) {
- report_error(fp, "invalid block header");
- return -1;
- }
- int block_length = unpackInt16((uint8_t*)&header[16]) + 1;
- bgzf_byte_t* compressed_block = (bgzf_byte_t*) fp->compressed_block;
- memcpy(compressed_block, header, BLOCK_HEADER_LENGTH);
- int remaining = block_length - BLOCK_HEADER_LENGTH;
-#ifdef _USE_KNETFILE
- count = knet_read(fp->x.fpr, &compressed_block[BLOCK_HEADER_LENGTH], remaining);
-#else
- count = fread(&compressed_block[BLOCK_HEADER_LENGTH], 1, remaining, fp->file);
-#endif
- if (count != remaining) {
- report_error(fp, "read failed");
- return -1;
- }
- size += count;
- count = inflate_block(fp, block_length);
- if (count < 0) {
- return -1;
- }
- if (fp->block_length != 0) {
- // Do not reset offset if this read follows a seek.
- fp->block_offset = 0;
- }
- fp->block_address = block_address;
- fp->block_length = count;
- cache_block(fp, size);
- return 0;
-}
-
-int
-bgzf_read(BGZF* fp, void* data, int length)
-{
- if (length <= 0) {
- return 0;
- }
- if (fp->open_mode != 'r') {
- report_error(fp, "file not open for reading");
- return -1;
- }
-
- int bytes_read = 0;
- bgzf_byte_t* output = data;
- while (bytes_read < length) {
- int available = fp->block_length - fp->block_offset;
- if (available <= 0) {
- if (bgzf_read_block(fp) != 0) {
- return -1;
- }
- available = fp->block_length - fp->block_offset;
- if (available <= 0) {
- break;
- }
- }
- int copy_length = bgzf_min(length-bytes_read, available);
- bgzf_byte_t* buffer = fp->uncompressed_block;
- memcpy(output, buffer + fp->block_offset, copy_length);
- fp->block_offset += copy_length;
- output += copy_length;
- bytes_read += copy_length;
- }
- if (fp->block_offset == fp->block_length) {
-#ifdef _USE_KNETFILE
- fp->block_address = knet_tell(fp->x.fpr);
-#else
- fp->block_address = ftello(fp->file);
-#endif
- fp->block_offset = 0;
- fp->block_length = 0;
- }
- return bytes_read;
-}
-
-static
-int
-flush_block(BGZF* fp)
-{
- while (fp->block_offset > 0) {
- int block_length = deflate_block(fp, fp->block_offset);
- if (block_length < 0) {
- return -1;
- }
-#ifdef _USE_KNETFILE
- int count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
-#else
- int count = fwrite(fp->compressed_block, 1, block_length, fp->file);
-#endif
- if (count != block_length) {
- report_error(fp, "write failed");
- return -1;
- }
- fp->block_address += block_length;
- }
- return 0;
-}
-
-int
-bgzf_write(BGZF* fp, const void* data, int length)
-{
- if (fp->open_mode != 'w') {
- report_error(fp, "file not open for writing");
- return -1;
- }
-
- if (fp->uncompressed_block == NULL) {
- fp->uncompressed_block = malloc(fp->uncompressed_block_size);
- }
-
- const bgzf_byte_t* input = data;
- int block_length = fp->uncompressed_block_size;
- int bytes_written = 0;
- while (bytes_written < length) {
- int copy_length = bgzf_min(block_length - fp->block_offset, length - bytes_written);
- bgzf_byte_t* buffer = fp->uncompressed_block;
- memcpy(buffer + fp->block_offset, input, copy_length);
- fp->block_offset += copy_length;
- input += copy_length;
- bytes_written += copy_length;
- if (fp->block_offset == block_length) {
- if (flush_block(fp) != 0) {
- break;
- }
- }
- }
- return bytes_written;
-}
-
-int
-bgzf_close(BGZF* fp)
-{
- if (fp->open_mode == 'w') {
- if (flush_block(fp) != 0) {
- return -1;
- }
- { // add an empty block
- int count, block_length = deflate_block(fp, 0);
-#ifdef _USE_KNETFILE
- count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
-#else
- count = fwrite(fp->compressed_block, 1, block_length, fp->file);
-#endif
- }
-#ifdef _USE_KNETFILE
- if (fflush(fp->x.fpw) != 0) {
-#else
- if (fflush(fp->file) != 0) {
-#endif
- report_error(fp, "flush failed");
- return -1;
- }
- }
- if (fp->owned_file) {
-#ifdef _USE_KNETFILE
- int ret;
- if (fp->open_mode == 'w') ret = fclose(fp->x.fpw);
- else ret = knet_close(fp->x.fpr);
- if (ret != 0) return -1;
-#else
- if (fclose(fp->file) != 0) {
- return -1;
- }
-#endif
- }
- free(fp->uncompressed_block);
- free(fp->compressed_block);
- free_cache(fp);
- free(fp);
- return 0;
-}
-
-void bgzf_set_cache_size(BGZF *fp, int cache_size)
-{
- if (fp) fp->cache_size = cache_size;
-}
-
-int bgzf_check_EOF(BGZF *fp)
-{
- static uint8_t magic[28] = "\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\033\0\3\0\0\0\0\0\0\0\0\0";
- uint8_t buf[28];
- off_t offset;
-#ifdef _USE_KNETFILE
- offset = knet_tell(fp->x.fpr);
- if (knet_seek(fp->x.fpr, -28, SEEK_END) != 0) return -1;
- knet_read(fp->x.fpr, buf, 28);
- knet_seek(fp->x.fpr, offset, SEEK_SET);
-#else
- offset = ftello(fp->file);
- if (fseeko(fp->file, -28, SEEK_END) != 0) return -1;
- fread(buf, 1, 28, fp->file);
- fseeko(fp->file, offset, SEEK_SET);
-#endif
- return (memcmp(magic, buf, 28) == 0)? 1 : 0;
-}
-
-int64_t
-bgzf_seek(BGZF* fp, int64_t pos, int where)
-{
- if (fp->open_mode != 'r') {
- report_error(fp, "file not open for read");
- return -1;
- }
- if (where != SEEK_SET) {
- report_error(fp, "unimplemented seek option");
- return -1;
- }
- int block_offset = pos & 0xFFFF;
- int64_t block_address = (pos >> 16) & 0xFFFFFFFFFFFFLL;
-#ifdef _USE_KNETFILE
- if (knet_seek(fp->x.fpr, block_address, SEEK_SET) != 0) {
-#else
- if (fseeko(fp->file, block_address, SEEK_SET) != 0) {
-#endif
- report_error(fp, "seek failed");
- return -1;
- }
- fp->block_length = 0; // indicates current block is not loaded
- fp->block_address = block_address;
- fp->block_offset = block_offset;
- return 0;
-}
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
+
+ Permission is hereby granted, free of charge, to any person obtaining a copy
+ of this software and associated documentation files (the "Software"), to deal
+ in the Software without restriction, including without limitation the rights
+ to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+ copies of the Software, and to permit persons to whom the Software is
+ furnished to do so, subject to the following conditions:
+
+ The above copyright notice and this permission notice shall be included in
+ all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+ IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+ FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+ LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+ OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
+ THE SOFTWARE.
+*/
+
+/*
+ 2009-06-29 by lh3: cache recent uncompressed blocks.
+ 2009-06-25 by lh3: optionally use my knetfile library to access file on a FTP.
+ 2009-06-12 by lh3: support a mode string like "wu" where 'u' for uncompressed output */
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+#include <unistd.h>
+#include <fcntl.h>
+#include <sys/types.h>
+#include <sys/stat.h>
+#include "bgzf.h"
+
+#include "khash.h"
+typedef struct {
+ int size;
+ uint8_t *block;
+ int64_t end_offset;
+} cache_t;
+KHASH_MAP_INIT_INT64(cache, cache_t)
+
+#if defined(_WIN32) || defined(_MSC_VER)
+#define ftello(fp) ftell(fp)
+#define fseeko(fp, offset, whence) fseek(fp, offset, whence)
+#else
+extern off_t ftello(FILE *stream);
+extern int fseeko(FILE *stream, off_t offset, int whence);
+#endif
+
+typedef int8_t bgzf_byte_t;
+
+static const int DEFAULT_BLOCK_SIZE = 64 * 1024;
+static const int MAX_BLOCK_SIZE = 64 * 1024;
+
+static const int BLOCK_HEADER_LENGTH = 18;
+static const int BLOCK_FOOTER_LENGTH = 8;
+
+static const int GZIP_ID1 = 31;
+static const int GZIP_ID2 = 139;
+static const int CM_DEFLATE = 8;
+static const int FLG_FEXTRA = 4;
+static const int OS_UNKNOWN = 255;
+static const int BGZF_ID1 = 66; // 'B'
+static const int BGZF_ID2 = 67; // 'C'
+static const int BGZF_LEN = 2;
+static const int BGZF_XLEN = 6; // BGZF_LEN+4
+
+static const int GZIP_WINDOW_BITS = -15; // no zlib header
+static const int Z_DEFAULT_MEM_LEVEL = 8;
+
+
+inline
+void
+packInt16(uint8_t* buffer, uint16_t value)
+{
+ buffer[0] = value;
+ buffer[1] = value >> 8;
+}
+
+inline
+int
+unpackInt16(const uint8_t* buffer)
+{
+ return (buffer[0] | (buffer[1] << 8));
+}
+
+inline
+void
+packInt32(uint8_t* buffer, uint32_t value)
+{
+ buffer[0] = value;
+ buffer[1] = value >> 8;
+ buffer[2] = value >> 16;
+ buffer[3] = value >> 24;
+}
+
+static inline
+int
+bgzf_min(int x, int y)
+{
+ return (x < y) ? x : y;
+}
+
+static
+void
+report_error(BGZF* fp, const char* message) {
+ fp->error = message;
+}
+
+int bgzf_check_bgzf(const char *fn)
+{
+ BGZF *fp;
+ uint8_t buf[10],magic[10]="\037\213\010\4\0\0\0\0\0\377";
+ int n;
+
+ if ((fp = bgzf_open(fn, "r")) == 0)
+ {
+ fprintf(pysamerr, "[bgzf_check_bgzf] failed to open the file: %s\n",fn);
+ return -1;
+ }
+
+#ifdef _USE_KNETFILE
+ n = knet_read(fp->x.fpr, buf, 10);
+#else
+ n = fread(buf, 1, 10, fp->file);
+#endif
+ bgzf_close(fp);
+
+ if ( n!=10 )
+ return -1;
+
+ if ( !memcmp(magic, buf, 10) ) return 1;
+ return 0;
+}
+
+static BGZF *bgzf_read_init()
+{
+ BGZF *fp;
+ fp = calloc(1, sizeof(BGZF));
+ fp->uncompressed_block_size = MAX_BLOCK_SIZE;
+ fp->uncompressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->compressed_block_size = MAX_BLOCK_SIZE;
+ fp->compressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->cache_size = 0;
+ fp->cache = kh_init(cache);
+ return fp;
+}
+
+static
+BGZF*
+open_read(int fd)
+{
+#ifdef _USE_KNETFILE
+ knetFile *file = knet_dopen(fd, "r");
+#else
+ FILE* file = fdopen(fd, "r");
+#endif
+ BGZF* fp;
+ if (file == 0) return 0;
+ fp = bgzf_read_init();
+ fp->file_descriptor = fd;
+ fp->open_mode = 'r';
+#ifdef _USE_KNETFILE
+ fp->x.fpr = file;
+#else
+ fp->file = file;
+#endif
+ return fp;
+}
+
+static
+BGZF*
+open_write(int fd, int compress_level) // compress_level==-1 for the default level
+{
+ FILE* file = fdopen(fd, "w");
+ BGZF* fp;
+ if (file == 0) return 0;
+ fp = malloc(sizeof(BGZF));
+ fp->file_descriptor = fd;
+ fp->open_mode = 'w';
+ fp->owned_file = 0;
+ fp->compress_level = compress_level < 0? Z_DEFAULT_COMPRESSION : compress_level; // Z_DEFAULT_COMPRESSION==-1
+ if (fp->compress_level > 9) fp->compress_level = Z_DEFAULT_COMPRESSION;
+#ifdef _USE_KNETFILE
+ fp->x.fpw = file;
+#else
+ fp->file = file;
+#endif
+ fp->uncompressed_block_size = DEFAULT_BLOCK_SIZE;
+ fp->uncompressed_block = NULL;
+ fp->compressed_block_size = MAX_BLOCK_SIZE;
+ fp->compressed_block = malloc(MAX_BLOCK_SIZE);
+ fp->block_address = 0;
+ fp->block_offset = 0;
+ fp->block_length = 0;
+ fp->error = NULL;
+ return fp;
+}
+
+BGZF*
+bgzf_open(const char* __restrict path, const char* __restrict mode)
+{
+ BGZF* fp = NULL;
+ if (strchr(mode, 'r') || strchr(mode, 'R')) { /* The reading mode is preferred. */
+#ifdef _USE_KNETFILE
+ knetFile *file = knet_open(path, mode);
+ if (file == 0) return 0;
+ fp = bgzf_read_init();
+ fp->file_descriptor = -1;
+ fp->open_mode = 'r';
+ fp->x.fpr = file;
+#else
+ int fd, oflag = O_RDONLY;
+#ifdef _WIN32
+ oflag |= O_BINARY;
+#endif
+ fd = open(path, oflag);
+ if (fd == -1) return 0;
+ fp = open_read(fd);
+#endif
+ } else if (strchr(mode, 'w') || strchr(mode, 'W')) {
+ int fd, compress_level = -1, oflag = O_WRONLY | O_CREAT | O_TRUNC;
+#ifdef _WIN32
+ oflag |= O_BINARY;
+#endif
+ fd = open(path, oflag, 0666);
+ if (fd == -1) return 0;
+ { // set compress_level
+ int i;
+ for (i = 0; mode[i]; ++i)
+ if (mode[i] >= '0' && mode[i] <= '9') break;
+ if (mode[i]) compress_level = (int)mode[i] - '0';
+ if (strchr(mode, 'u')) compress_level = 0;
+ }
+ fp = open_write(fd, compress_level);
+ }
+ if (fp != NULL) fp->owned_file = 1;
+ return fp;
+}
+
+BGZF*
+bgzf_fdopen(int fd, const char * __restrict mode)
+{
+ if (fd == -1) return 0;
+ if (mode[0] == 'r' || mode[0] == 'R') {
+ return open_read(fd);
+ } else if (mode[0] == 'w' || mode[0] == 'W') {
+ int i, compress_level = -1;
+ for (i = 0; mode[i]; ++i)
+ if (mode[i] >= '0' && mode[i] <= '9') break;
+ if (mode[i]) compress_level = (int)mode[i] - '0';
+ if (strchr(mode, 'u')) compress_level = 0;
+ return open_write(fd, compress_level);
+ } else {
+ return NULL;
+ }
+}
+
+static
+int
+deflate_block(BGZF* fp, int block_length)
+{
+ // Deflate the block in fp->uncompressed_block into fp->compressed_block.
+ // Also adds an extra field that stores the compressed block length.
+
+ bgzf_byte_t* buffer = fp->compressed_block;
+ int buffer_size = fp->compressed_block_size;
+
+ // Init gzip header
+ buffer[0] = GZIP_ID1;
+ buffer[1] = GZIP_ID2;
+ buffer[2] = CM_DEFLATE;
+ buffer[3] = FLG_FEXTRA;
+ buffer[4] = 0; // mtime
+ buffer[5] = 0;
+ buffer[6] = 0;
+ buffer[7] = 0;
+ buffer[8] = 0;
+ buffer[9] = OS_UNKNOWN;
+ buffer[10] = BGZF_XLEN;
+ buffer[11] = 0;
+ buffer[12] = BGZF_ID1;
+ buffer[13] = BGZF_ID2;
+ buffer[14] = BGZF_LEN;
+ buffer[15] = 0;
+ buffer[16] = 0; // placeholder for block length
+ buffer[17] = 0;
+
+ // loop to retry for blocks that do not compress enough
+ int input_length = block_length;
+ int compressed_length = 0;
+ while (1) {
+ z_stream zs;
+ zs.zalloc = NULL;
+ zs.zfree = NULL;
+ zs.next_in = fp->uncompressed_block;
+ zs.avail_in = input_length;
+ zs.next_out = (void*)&buffer[BLOCK_HEADER_LENGTH];
+ zs.avail_out = buffer_size - BLOCK_HEADER_LENGTH - BLOCK_FOOTER_LENGTH;
+
+ int status = deflateInit2(&zs, fp->compress_level, Z_DEFLATED,
+ GZIP_WINDOW_BITS, Z_DEFAULT_MEM_LEVEL, Z_DEFAULT_STRATEGY);
+ if (status != Z_OK) {
+ report_error(fp, "deflate init failed");
+ return -1;
+ }
+ status = deflate(&zs, Z_FINISH);
+ if (status != Z_STREAM_END) {
+ deflateEnd(&zs);
+ if (status == Z_OK) {
+ // Not enough space in buffer.
+ // Can happen in the rare case the input doesn't compress enough.
+ // Reduce the amount of input until it fits.
+ input_length -= 1024;
+ if (input_length <= 0) {
+ // should never happen
+ report_error(fp, "input reduction failed");
+ return -1;
+ }
+ continue;
+ }
+ report_error(fp, "deflate failed");
+ return -1;
+ }
+ status = deflateEnd(&zs);
+ if (status != Z_OK) {
+ report_error(fp, "deflate end failed");
+ return -1;
+ }
+ compressed_length = zs.total_out;
+ compressed_length += BLOCK_HEADER_LENGTH + BLOCK_FOOTER_LENGTH;
+ if (compressed_length > MAX_BLOCK_SIZE) {
+ // should never happen
+ report_error(fp, "deflate overflow");
+ return -1;
+ }
+ break;
+ }
+
+ packInt16((uint8_t*)&buffer[16], compressed_length-1);
+ uint32_t crc = crc32(0L, NULL, 0L);
+ crc = crc32(crc, fp->uncompressed_block, input_length);
+ packInt32((uint8_t*)&buffer[compressed_length-8], crc);
+ packInt32((uint8_t*)&buffer[compressed_length-4], input_length);
+
+ int remaining = block_length - input_length;
+ if (remaining > 0) {
+ if (remaining > input_length) {
+ // should never happen (check so we can use memcpy)
+ report_error(fp, "remainder too large");
+ return -1;
+ }
+ memcpy(fp->uncompressed_block,
+ fp->uncompressed_block + input_length,
+ remaining);
+ }
+ fp->block_offset = remaining;
+ return compressed_length;
+}
+
+static
+int
+inflate_block(BGZF* fp, int block_length)
+{
+ // Inflate the block in fp->compressed_block into fp->uncompressed_block
+
+ z_stream zs;
+ int status;
+ zs.zalloc = NULL;
+ zs.zfree = NULL;
+ zs.next_in = fp->compressed_block + 18;
+ zs.avail_in = block_length - 16;
+ zs.next_out = fp->uncompressed_block;
+ zs.avail_out = fp->uncompressed_block_size;
+
+ status = inflateInit2(&zs, GZIP_WINDOW_BITS);
+ if (status != Z_OK) {
+ report_error(fp, "inflate init failed");
+ return -1;
+ }
+ status = inflate(&zs, Z_FINISH);
+ if (status != Z_STREAM_END) {
+ inflateEnd(&zs);
+ report_error(fp, "inflate failed");
+ return -1;
+ }
+ status = inflateEnd(&zs);
+ if (status != Z_OK) {
+ report_error(fp, "inflate failed");
+ return -1;
+ }
+ return zs.total_out;
+}
+
+static
+int
+check_header(const bgzf_byte_t* header)
+{
+ return (header[0] == GZIP_ID1 &&
+ header[1] == (bgzf_byte_t) GZIP_ID2 &&
+ header[2] == Z_DEFLATED &&
+ (header[3] & FLG_FEXTRA) != 0 &&
+ unpackInt16((uint8_t*)&header[10]) == BGZF_XLEN &&
+ header[12] == BGZF_ID1 &&
+ header[13] == BGZF_ID2 &&
+ unpackInt16((uint8_t*)&header[14]) == BGZF_LEN);
+}
+
+static void free_cache(BGZF *fp)
+{
+ khint_t k;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ if (fp->open_mode != 'r') return;
+ for (k = kh_begin(h); k < kh_end(h); ++k)
+ if (kh_exist(h, k)) free(kh_val(h, k).block);
+ kh_destroy(cache, h);
+}
+
+static int load_block_from_cache(BGZF *fp, int64_t block_address)
+{
+ khint_t k;
+ cache_t *p;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ k = kh_get(cache, h, block_address);
+ if (k == kh_end(h)) return 0;
+ p = &kh_val(h, k);
+ if (fp->block_length != 0) fp->block_offset = 0;
+ fp->block_address = block_address;
+ fp->block_length = p->size;
+ memcpy(fp->uncompressed_block, p->block, MAX_BLOCK_SIZE);
+#ifdef _USE_KNETFILE
+ knet_seek(fp->x.fpr, p->end_offset, SEEK_SET);
+#else
+ fseeko(fp->file, p->end_offset, SEEK_SET);
+#endif
+ return p->size;
+}
+
+static void cache_block(BGZF *fp, int size)
+{
+ int ret;
+ khint_t k;
+ cache_t *p;
+ khash_t(cache) *h = (khash_t(cache)*)fp->cache;
+ if (MAX_BLOCK_SIZE >= fp->cache_size) return;
+ if ((kh_size(h) + 1) * MAX_BLOCK_SIZE > fp->cache_size) {
+ /* A better way would be to remove the oldest block in the
+ * cache, but here we remove a random one for simplicity. This
+ * should not have a big impact on performance. */
+ for (k = kh_begin(h); k < kh_end(h); ++k)
+ if (kh_exist(h, k)) break;
+ if (k < kh_end(h)) {
+ free(kh_val(h, k).block);
+ kh_del(cache, h, k);
+ }
+ }
+ k = kh_put(cache, h, fp->block_address, &ret);
+ if (ret == 0) return; // if this happens, a bug!
+ p = &kh_val(h, k);
+ p->size = fp->block_length;
+ p->end_offset = fp->block_address + size;
+ p->block = malloc(MAX_BLOCK_SIZE);
+ memcpy(kh_val(h, k).block, fp->uncompressed_block, MAX_BLOCK_SIZE);
+}
+
+int
+bgzf_read_block(BGZF* fp)
+{
+ bgzf_byte_t header[BLOCK_HEADER_LENGTH];
+ int count, size = 0, block_length, remaining;
+#ifdef _USE_KNETFILE
+ int64_t block_address = knet_tell(fp->x.fpr);
+ if (load_block_from_cache(fp, block_address)) return 0;
+ count = knet_read(fp->x.fpr, header, sizeof(header));
+#else
+ int64_t block_address = ftello(fp->file);
+ if (load_block_from_cache(fp, block_address)) return 0;
+ count = fread(header, 1, sizeof(header), fp->file);
+#endif
+ if (count == 0) {
+ fp->block_length = 0;
+ return 0;
+ }
+ size = count;
+ if (count != sizeof(header)) {
+ report_error(fp, "read failed");
+ return -1;
+ }
+ if (!check_header(header)) {
+ report_error(fp, "invalid block header");
+ return -1;
+ }
+ block_length = unpackInt16((uint8_t*)&header[16]) + 1;
+ bgzf_byte_t* compressed_block = (bgzf_byte_t*) fp->compressed_block;
+ memcpy(compressed_block, header, BLOCK_HEADER_LENGTH);
+ remaining = block_length - BLOCK_HEADER_LENGTH;
+#ifdef _USE_KNETFILE
+ count = knet_read(fp->x.fpr, &compressed_block[BLOCK_HEADER_LENGTH], remaining);
+#else
+ count = fread(&compressed_block[BLOCK_HEADER_LENGTH], 1, remaining, fp->file);
+#endif
+ if (count != remaining) {
+ report_error(fp, "read failed");
+ return -1;
+ }
+ size += count;
+ count = inflate_block(fp, block_length);
+ if (count < 0) return -1;
+ if (fp->block_length != 0) {
+ // Do not reset offset if this read follows a seek.
+ fp->block_offset = 0;
+ }
+ fp->block_address = block_address;
+ fp->block_length = count;
+ cache_block(fp, size);
+ return 0;
+}
+
+int
+bgzf_read(BGZF* fp, void* data, int length)
+{
+ if (length <= 0) {
+ return 0;
+ }
+ if (fp->open_mode != 'r') {
+ report_error(fp, "file not open for reading");
+ return -1;
+ }
+
+ int bytes_read = 0;
+ bgzf_byte_t* output = data;
+ while (bytes_read < length) {
+ int copy_length, available = fp->block_length - fp->block_offset;
+ bgzf_byte_t *buffer;
+ if (available <= 0) {
+ if (bgzf_read_block(fp) != 0) {
+ return -1;
+ }
+ available = fp->block_length - fp->block_offset;
+ if (available <= 0) {
+ break;
+ }
+ }
+ copy_length = bgzf_min(length-bytes_read, available);
+ buffer = fp->uncompressed_block;
+ memcpy(output, buffer + fp->block_offset, copy_length);
+ fp->block_offset += copy_length;
+ output += copy_length;
+ bytes_read += copy_length;
+ }
+ if (fp->block_offset == fp->block_length) {
+#ifdef _USE_KNETFILE
+ fp->block_address = knet_tell(fp->x.fpr);
+#else
+ fp->block_address = ftello(fp->file);
+#endif
+ fp->block_offset = 0;
+ fp->block_length = 0;
+ }
+ return bytes_read;
+}
+
+int bgzf_flush(BGZF* fp)
+{
+ while (fp->block_offset > 0) {
+ int count, block_length;
+ block_length = deflate_block(fp, fp->block_offset);
+ if (block_length < 0) return -1;
+#ifdef _USE_KNETFILE
+ count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
+#else
+ count = fwrite(fp->compressed_block, 1, block_length, fp->file);
+#endif
+ if (count != block_length) {
+ report_error(fp, "write failed");
+ return -1;
+ }
+ fp->block_address += block_length;
+ }
+ return 0;
+}
+
+int bgzf_flush_try(BGZF *fp, int size)
+{
+ if (fp->block_offset + size > fp->uncompressed_block_size)
+ return bgzf_flush(fp);
+ return -1;
+}
+
+int bgzf_write(BGZF* fp, const void* data, int length)
+{
+ const bgzf_byte_t *input = data;
+ int block_length, bytes_written;
+ if (fp->open_mode != 'w') {
+ report_error(fp, "file not open for writing");
+ return -1;
+ }
+
+ if (fp->uncompressed_block == NULL)
+ fp->uncompressed_block = malloc(fp->uncompressed_block_size);
+
+ input = data;
+ block_length = fp->uncompressed_block_size;
+ bytes_written = 0;
+ while (bytes_written < length) {
+ int copy_length = bgzf_min(block_length - fp->block_offset, length - bytes_written);
+ bgzf_byte_t* buffer = fp->uncompressed_block;
+ memcpy(buffer + fp->block_offset, input, copy_length);
+ fp->block_offset += copy_length;
+ input += copy_length;
+ bytes_written += copy_length;
+ if (fp->block_offset == block_length) {
+ if (bgzf_flush(fp) != 0) {
+ break;
+ }
+ }
+ }
+ return bytes_written;
+}
+
+int bgzf_close(BGZF* fp)
+{
+ if (fp->open_mode == 'w') {
+ if (bgzf_flush(fp) != 0) return -1;
+ { // add an empty block
+ int count, block_length = deflate_block(fp, 0);
+#ifdef _USE_KNETFILE
+ count = fwrite(fp->compressed_block, 1, block_length, fp->x.fpw);
+#else
+ count = fwrite(fp->compressed_block, 1, block_length, fp->file);
+#endif
+ }
+#ifdef _USE_KNETFILE
+ if (fflush(fp->x.fpw) != 0) {
+#else
+ if (fflush(fp->file) != 0) {
+#endif
+ report_error(fp, "flush failed");
+ return -1;
+ }
+ }
+ if (fp->owned_file) {
+#ifdef _USE_KNETFILE
+ int ret;
+ if (fp->open_mode == 'w') ret = fclose(fp->x.fpw);
+ else ret = knet_close(fp->x.fpr);
+ if (ret != 0) return -1;
+#else
+ if (fclose(fp->file) != 0) return -1;
+#endif
+ }
+ free(fp->uncompressed_block);
+ free(fp->compressed_block);
+ free_cache(fp);
+ free(fp);
+ return 0;
+}
+
+void bgzf_set_cache_size(BGZF *fp, int cache_size)
+{
+ if (fp) fp->cache_size = cache_size;
+}
+
+int bgzf_check_EOF(BGZF *fp)
+{
+ static uint8_t magic[28] = "\037\213\010\4\0\0\0\0\0\377\6\0\102\103\2\0\033\0\3\0\0\0\0\0\0\0\0\0";
+ uint8_t buf[28];
+ off_t offset;
+#ifdef _USE_KNETFILE
+ offset = knet_tell(fp->x.fpr);
+ if (knet_seek(fp->x.fpr, -28, SEEK_END) != 0) return -1;
+ knet_read(fp->x.fpr, buf, 28);
+ knet_seek(fp->x.fpr, offset, SEEK_SET);
+#else
+ offset = ftello(fp->file);
+ if (fseeko(fp->file, -28, SEEK_END) != 0) return -1;
+ fread(buf, 1, 28, fp->file);
+ fseeko(fp->file, offset, SEEK_SET);
+#endif
+ return (memcmp(magic, buf, 28) == 0)? 1 : 0;
+}
+
+int64_t bgzf_seek(BGZF* fp, int64_t pos, int where)
+{
+ int block_offset;
+ int64_t block_address;
+
+ if (fp->open_mode != 'r') {
+ report_error(fp, "file not open for read");
+ return -1;
+ }
+ if (where != SEEK_SET) {
+ report_error(fp, "unimplemented seek option");
+ return -1;
+ }
+ block_offset = pos & 0xFFFF;
+ block_address = (pos >> 16) & 0xFFFFFFFFFFFFLL;
+#ifdef _USE_KNETFILE
+ if (knet_seek(fp->x.fpr, block_address, SEEK_SET) != 0) {
+#else
+ if (fseeko(fp->file, block_address, SEEK_SET) != 0) {
+#endif
+ report_error(fp, "seek failed");
+ return -1;
+ }
+ fp->block_length = 0; // indicates current block is not loaded
+ fp->block_address = block_address;
+ fp->block_offset = block_offset;
+ return 0;
+}
#include <stdint.h>
#include <stdio.h>
-#include <stdbool.h>
#include <zlib.h>
#ifdef _USE_KNETFILE
#include "knetfile.h"
typedef struct {
int file_descriptor;
char open_mode; // 'r' or 'w'
- bool owned_file, is_uncompressed;
+ int16_t owned_file, compress_level;
#ifdef _USE_KNETFILE
union {
knetFile *fpr;
void bgzf_set_cache_size(BGZF *fp, int cache_size);
int bgzf_check_EOF(BGZF *fp);
-
int bgzf_read_block(BGZF* fp);
+int bgzf_flush(BGZF* fp);
+int bgzf_flush_try(BGZF *fp, int size);
+int bgzf_check_bgzf(const char *fn);
#ifdef __cplusplus
}
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
-
- Permission is hereby granted, free of charge, to any person obtaining a copy
- of this software and associated documentation files (the "Software"), to deal
- in the Software without restriction, including without limitation the rights
- to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
- copies of the Software, and to permit persons to whom the Software is
- furnished to do so, subject to the following conditions:
-
- The above copyright notice and this permission notice shall be included in
- all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
- IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
- FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
- AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
- LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
- OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
- THE SOFTWARE.
-*/
-
-#include <stdlib.h>
-#include <string.h>
-#include <stdio.h>
-#include <fcntl.h>
-#include <unistd.h>
-#include <errno.h>
-#include <sys/select.h>
-#include <sys/stat.h>
-#include "bgzf.h"
-
-static const int WINDOW_SIZE = 64 * 1024;
-
-static int bgzip_main_usage()
-{
- fprintf(stderr, "\n");
- fprintf(stderr, "Usage: bgzip [options] [file] ...\n\n");
- fprintf(stderr, "Options: -c write on standard output, keep original files unchanged\n");
- fprintf(stderr, " -d decompress\n");
- fprintf(stderr, " -f overwrite files without asking\n");
- fprintf(stderr, " -b INT decompress at virtual file pointer INT\n");
- fprintf(stderr, " -s INT decompress INT bytes in the uncompressed file\n");
- fprintf(stderr, " -h give this help\n");
- fprintf(stderr, "\n");
- return 1;
-}
-
-static int write_open(const char *fn, int is_forced)
-{
- int fd = -1;
- char c;
- if (!is_forced) {
- if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC | O_EXCL, 0666)) < 0 && errno == EEXIST) {
- fprintf(stderr, "[bgzip] %s already exists; do you wish to overwrite (y or n)? ", fn);
- scanf("%c", &c);
- if (c != 'Y' && c != 'y') {
- fprintf(stderr, "[bgzip] not overwritten\n");
- exit(1);
- }
- }
- }
- if (fd < 0) {
- if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC, 0666)) < 0) {
- fprintf(stderr, "[bgzip] %s: Fail to write\n", fn);
- exit(1);
- }
- }
- return fd;
-}
-
-static void fail(BGZF* fp)
-{
- fprintf(stderr, "Error: %s\n", fp->error);
- exit(1);
-}
-
-int main(int argc, char **argv)
-{
- int c, compress, pstdout, is_forced;
- BGZF *fp;
- void *buffer;
- long start, end, size;
-
- compress = 1; pstdout = 0; start = 0; size = -1; end = -1; is_forced = 0;
- while((c = getopt(argc, argv, "cdhfb:s:")) >= 0){
- switch(c){
- case 'h': return bgzip_main_usage();
- case 'd': compress = 0; break;
- case 'c': pstdout = 1; break;
- case 'b': start = atol(optarg); break;
- case 's': size = atol(optarg); break;
- case 'f': is_forced = 1; break;
- }
- }
- if (size >= 0) end = start + size;
- if (end >= 0 && end < start) {
- fprintf(stderr, "[bgzip] Illegal region: [%ld, %ld]\n", start, end);
- return 1;
- }
- if (compress == 1) {
- struct stat sbuf;
- int f_src = fileno(stdin);
- int f_dst = fileno(stdout);
-
- if ( argc>optind )
- {
- if ( stat(argv[optind],&sbuf)<0 )
- {
- fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
- return 1;
- }
-
- if ((f_src = open(argv[optind], O_RDONLY)) < 0) {
- fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
- return 1;
- }
-
- if (pstdout)
- f_dst = fileno(stdout);
- else
- {
- char *name = malloc(strlen(argv[optind]) + 5);
- strcpy(name, argv[optind]);
- strcat(name, ".gz");
- f_dst = write_open(name, is_forced);
- if (f_dst < 0) return 1;
- free(name);
- }
- }
- else if (!pstdout && isatty(fileno((FILE *)stdout)) )
- return bgzip_main_usage();
-
- fp = bgzf_fdopen(f_dst, "w");
- buffer = malloc(WINDOW_SIZE);
- while ((c = read(f_src, buffer, WINDOW_SIZE)) > 0)
- if (bgzf_write(fp, buffer, c) < 0) fail(fp);
- // f_dst will be closed here
- if (bgzf_close(fp) < 0) fail(fp);
- if (argc > optind) unlink(argv[optind]);
- free(buffer);
- close(f_src);
- return 0;
- } else {
- struct stat sbuf;
- int f_dst;
-
- if ( argc>optind )
- {
- if ( stat(argv[optind],&sbuf)<0 )
- {
- fprintf(stderr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
- return 1;
- }
- char *name;
- int len = strlen(argv[optind]);
- if ( strcmp(argv[optind]+len-3,".gz") )
- {
- fprintf(stderr, "[bgzip] %s: unknown suffix -- ignored\n", argv[optind]);
- return 1;
- }
- fp = bgzf_open(argv[optind], "r");
- if (fp == NULL) {
- fprintf(stderr, "[bgzip] Could not open file: %s\n", argv[optind]);
- return 1;
- }
-
- name = strdup(argv[optind]);
- name[strlen(name) - 3] = '\0';
- f_dst = write_open(name, is_forced);
- free(name);
- }
- else if (!pstdout && isatty(fileno((FILE *)stdin)) )
- return bgzip_main_usage();
- else
- {
- f_dst = fileno(stdout);
- fp = bgzf_fdopen(fileno(stdin), "r");
- if (fp == NULL) {
- fprintf(stderr, "[bgzip] Could not read from stdin: %s\n", strerror(errno));
- return 1;
- }
- }
- buffer = malloc(WINDOW_SIZE);
- if (bgzf_seek(fp, start, SEEK_SET) < 0) fail(fp);
- while (1) {
- if (end < 0) c = bgzf_read(fp, buffer, WINDOW_SIZE);
- else c = bgzf_read(fp, buffer, (end - start > WINDOW_SIZE)? WINDOW_SIZE:(end - start));
- if (c == 0) break;
- if (c < 0) fail(fp);
- start += c;
- write(f_dst, buffer, c);
- if (end >= 0 && start >= end) break;
- }
- free(buffer);
- if (bgzf_close(fp) < 0) fail(fp);
- if (!pstdout) unlink(argv[optind]);
- return 0;
- }
-}
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008 Broad Institute / Massachusetts Institute of Technology
+
+ Permission is hereby granted, free of charge, to any person obtaining a copy
+ of this software and associated documentation files (the "Software"), to deal
+ in the Software without restriction, including without limitation the rights
+ to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+ copies of the Software, and to permit persons to whom the Software is
+ furnished to do so, subject to the following conditions:
+
+ The above copyright notice and this permission notice shall be included in
+ all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+ IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+ FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+ LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+ OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
+ THE SOFTWARE.
+*/
+
+#include <stdlib.h>
+#include <string.h>
+#include <stdio.h>
+#include <fcntl.h>
+#include <unistd.h>
+#include <errno.h>
+#include <sys/select.h>
+#include <sys/stat.h>
+#include "bgzf.h"
+
+static const int WINDOW_SIZE = 64 * 1024;
+
+static int bgzip_main_usage()
+{
+ fprintf(pysamerr, "\n");
+ fprintf(pysamerr, "Usage: bgzip [options] [file] ...\n\n");
+ fprintf(pysamerr, "Options: -c write on standard output, keep original files unchanged\n");
+ fprintf(pysamerr, " -d decompress\n");
+ fprintf(pysamerr, " -f overwrite files without asking\n");
+ fprintf(pysamerr, " -b INT decompress at virtual file pointer INT\n");
+ fprintf(pysamerr, " -s INT decompress INT bytes in the uncompressed file\n");
+ fprintf(pysamerr, " -h give this help\n");
+ fprintf(pysamerr, "\n");
+ return 1;
+}
+
+static int write_open(const char *fn, int is_forced)
+{
+ int fd = -1;
+ char c;
+ if (!is_forced) {
+ if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC | O_EXCL, 0666)) < 0 && errno == EEXIST) {
+ fprintf(pysamerr, "[bgzip] %s already exists; do you wish to overwrite (y or n)? ", fn);
+ scanf("%c", &c);
+ if (c != 'Y' && c != 'y') {
+ fprintf(pysamerr, "[bgzip] not overwritten\n");
+ exit(1);
+ }
+ }
+ }
+ if (fd < 0) {
+ if ((fd = open(fn, O_WRONLY | O_CREAT | O_TRUNC, 0666)) < 0) {
+ fprintf(pysamerr, "[bgzip] %s: Fail to write\n", fn);
+ exit(1);
+ }
+ }
+ return fd;
+}
+
+static void fail(BGZF* fp)
+{
+ fprintf(pysamerr, "Error: %s\n", fp->error);
+ exit(1);
+}
+
+int main(int argc, char **argv)
+{
+ int c, compress, pstdout, is_forced;
+ BGZF *fp;
+ void *buffer;
+ long start, end, size;
+
+ compress = 1; pstdout = 0; start = 0; size = -1; end = -1; is_forced = 0;
+ while((c = getopt(argc, argv, "cdhfb:s:")) >= 0){
+ switch(c){
+ case 'h': return bgzip_main_usage();
+ case 'd': compress = 0; break;
+ case 'c': pstdout = 1; break;
+ case 'b': start = atol(optarg); break;
+ case 's': size = atol(optarg); break;
+ case 'f': is_forced = 1; break;
+ }
+ }
+ if (size >= 0) end = start + size;
+ if (end >= 0 && end < start) {
+ fprintf(pysamerr, "[bgzip] Illegal region: [%ld, %ld]\n", start, end);
+ return 1;
+ }
+ if (compress == 1) {
+ struct stat sbuf;
+ int f_src = fileno(stdin);
+ int f_dst = fileno(stdout);
+
+ if ( argc>optind )
+ {
+ if ( stat(argv[optind],&sbuf)<0 )
+ {
+ fprintf(pysamerr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
+ return 1;
+ }
+
+ if ((f_src = open(argv[optind], O_RDONLY)) < 0) {
+ fprintf(pysamerr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
+ return 1;
+ }
+
+ if (pstdout)
+ f_dst = fileno(stdout);
+ else
+ {
+ char *name = malloc(strlen(argv[optind]) + 5);
+ strcpy(name, argv[optind]);
+ strcat(name, ".gz");
+ f_dst = write_open(name, is_forced);
+ if (f_dst < 0) return 1;
+ free(name);
+ }
+ }
+ else if (!pstdout && isatty(fileno((FILE *)stdout)) )
+ return bgzip_main_usage();
+
+ fp = bgzf_fdopen(f_dst, "w");
+ buffer = malloc(WINDOW_SIZE);
+ while ((c = read(f_src, buffer, WINDOW_SIZE)) > 0)
+ if (bgzf_write(fp, buffer, c) < 0) fail(fp);
+ // f_dst will be closed here
+ if (bgzf_close(fp) < 0) fail(fp);
+ if (argc > optind && !pstdout) unlink(argv[optind]);
+ free(buffer);
+ close(f_src);
+ return 0;
+ } else {
+ struct stat sbuf;
+ int f_dst;
+
+ if ( argc>optind )
+ {
+ if ( stat(argv[optind],&sbuf)<0 )
+ {
+ fprintf(pysamerr, "[bgzip] %s: %s\n", strerror(errno), argv[optind]);
+ return 1;
+ }
+ char *name;
+ int len = strlen(argv[optind]);
+ if ( strcmp(argv[optind]+len-3,".gz") )
+ {
+ fprintf(pysamerr, "[bgzip] %s: unknown suffix -- ignored\n", argv[optind]);
+ return 1;
+ }
+ fp = bgzf_open(argv[optind], "r");
+ if (fp == NULL) {
+ fprintf(pysamerr, "[bgzip] Could not open file: %s\n", argv[optind]);
+ return 1;
+ }
+
+ if (pstdout) {
+ f_dst = fileno(stdout);
+ }
+ else {
+ name = strdup(argv[optind]);
+ name[strlen(name) - 3] = '\0';
+ f_dst = write_open(name, is_forced);
+ free(name);
+ }
+ }
+ else if (!pstdout && isatty(fileno((FILE *)stdin)) )
+ return bgzip_main_usage();
+ else
+ {
+ f_dst = fileno(stdout);
+ fp = bgzf_fdopen(fileno(stdin), "r");
+ if (fp == NULL) {
+ fprintf(pysamerr, "[bgzip] Could not read from stdin: %s\n", strerror(errno));
+ return 1;
+ }
+ }
+ buffer = malloc(WINDOW_SIZE);
+ if (bgzf_seek(fp, start, SEEK_SET) < 0) fail(fp);
+ while (1) {
+ if (end < 0) c = bgzf_read(fp, buffer, WINDOW_SIZE);
+ else c = bgzf_read(fp, buffer, (end - start > WINDOW_SIZE)? WINDOW_SIZE:(end - start));
+ if (c == 0) break;
+ if (c < 0) fail(fp);
+ start += c;
+ write(f_dst, buffer, c);
+ if (end >= 0 && start >= end) break;
+ }
+ free(buffer);
+ if (bgzf_close(fp) < 0) fail(fp);
+ if (!pstdout) unlink(argv[optind]);
+ return 0;
+ }
+}
+++ /dev/null
-#include <ctype.h>
-#include <assert.h>
-#include <sys/stat.h>
-#include "khash.h"
-#include "ksort.h"
-#include "kstring.h"
-#include "bam_endian.h"
-#ifdef _USE_KNETFILE
-#include "knetfile.h"
-#endif
-#include "tabix.h"
-
-#define TAD_MIN_CHUNK_GAP 32768
-// 1<<14 is the size of minimum bin.
-#define TAD_LIDX_SHIFT 14
-
-typedef struct {
- uint64_t u, v;
-} pair64_t;
-
-#define pair64_lt(a,b) ((a).u < (b).u)
-KSORT_INIT(off, pair64_t, pair64_lt)
-
-typedef struct {
- uint32_t m, n;
- pair64_t *list;
-} ti_binlist_t;
-
-typedef struct {
- int32_t n, m;
- uint64_t *offset;
-} ti_lidx_t;
-
-KHASH_MAP_INIT_INT(i, ti_binlist_t)
-KHASH_MAP_INIT_STR(s, int)
-
-struct __ti_index_t {
- ti_conf_t conf;
- int32_t n, max;
- khash_t(s) *tname;
- khash_t(i) **index;
- ti_lidx_t *index2;
-};
-
-struct __ti_iter_t {
- int from_first; // read from the first record; no random access
- int tid, beg, end, n_off, i, finished;
- uint64_t curr_off;
- kstring_t str;
- const ti_index_t *idx;
- pair64_t *off;
-};
-
-typedef struct {
- int tid, beg, end, bin;
-} ti_intv_t;
-
-ti_conf_t ti_conf_gff = { 0, 1, 4, 5, '#', 0 };
-ti_conf_t ti_conf_bed = { TI_FLAG_UCSC, 1, 2, 3, '#', 0 };
-ti_conf_t ti_conf_psltbl = { TI_FLAG_UCSC, 15, 17, 18, '#', 0 };
-ti_conf_t ti_conf_sam = { TI_PRESET_SAM, 3, 4, 0, '@', 0 };
-ti_conf_t ti_conf_vcf = { TI_PRESET_VCF, 1, 2, 0, '#', 0 };
-
-/***************
- * read a line *
- ***************/
-
-/*
-int ti_readline(BGZF *fp, kstring_t *str)
-{
- int c, l = 0;
- str->l = 0;
- while ((c = bgzf_getc(fp)) >= 0 && c != '\n') {
- ++l;
- if (c != '\r') kputc(c, str);
- }
- if (c < 0 && l == 0) return -1; // end of file
- return str->l;
-}
-*/
-
-/* Below is a faster implementation largely equivalent to the one
- * commented out above. */
-int ti_readline(BGZF *fp, kstring_t *str)
-{
- int l, state = 0;
- unsigned char *buf = (unsigned char*)fp->uncompressed_block;
- str->l = 0;
- do {
- if (fp->block_offset >= fp->block_length) {
- if (bgzf_read_block(fp) != 0) { state = -2; break; }
- if (fp->block_length == 0) { state = -1; break; }
- }
- for (l = fp->block_offset; l < fp->block_length && buf[l] != '\n'; ++l);
- if (l < fp->block_length) state = 1;
- l -= fp->block_offset;
- if (str->l + l + 1 >= str->m) {
- str->m = str->l + l + 2;
- kroundup32(str->m);
- str->s = (char*)realloc(str->s, str->m);
- }
- memcpy(str->s + str->l, buf + fp->block_offset, l);
- str->l += l;
- fp->block_offset += l + 1;
- if (fp->block_offset >= fp->block_length) {
-#ifdef _USE_KNETFILE
- fp->block_address = knet_tell(fp->x.fpr);
-#else
- fp->block_address = ftello(fp->file);
-#endif
- fp->block_offset = 0;
- fp->block_length = 0;
- }
- } while (state == 0);
- if (str->l == 0 && state < 0) return state;
- str->s[str->l] = 0;
- return str->l;
-}
-
-/*************************************
- * get the interval from a data line *
- *************************************/
-
-static inline int ti_reg2bin(uint32_t beg, uint32_t end)
-{
- --end;
- if (beg>>14 == end>>14) return 4681 + (beg>>14);
- if (beg>>17 == end>>17) return 585 + (beg>>17);
- if (beg>>20 == end>>20) return 73 + (beg>>20);
- if (beg>>23 == end>>23) return 9 + (beg>>23);
- if (beg>>26 == end>>26) return 1 + (beg>>26);
- return 0;
-}
-
-static int get_tid(ti_index_t *idx, const char *ss)
-{
- khint_t k;
- int tid;
- k = kh_get(s, idx->tname, ss);
- if (k == kh_end(idx->tname)) { // a new target sequence
- int ret, size;
- // update idx->n, ->max, ->index and ->index2
- if (idx->n == idx->max) {
- idx->max = idx->max? idx->max<<1 : 8;
- idx->index = realloc(idx->index, idx->max * sizeof(void*));
- idx->index2 = realloc(idx->index2, idx->max * sizeof(ti_lidx_t));
- }
- memset(&idx->index2[idx->n], 0, sizeof(ti_lidx_t));
- idx->index[idx->n++] = kh_init(i);
- // update ->tname
- tid = size = kh_size(idx->tname);
- k = kh_put(s, idx->tname, strdup(ss), &ret);
- kh_value(idx->tname, k) = size;
- assert(idx->n == kh_size(idx->tname));
- } else tid = kh_value(idx->tname, k);
- return tid;
-}
-
-static int get_intv(ti_index_t *idx, kstring_t *str, ti_intv_t *intv)
-{
- int i, b = 0, id = 1;
- char *s;
- intv->tid = intv->beg = intv->end = intv->bin = -1;
- for (i = 0; i <= str->l; ++i) {
- if (str->s[i] == '\t' || str->s[i] == 0) {
- if (id == idx->conf.sc) {
- str->s[i] = 0;
- intv->tid = get_tid(idx, str->s + b);
- if (i != str->l) str->s[i] = '\t';
- } else if (id == idx->conf.bc) {
- // here ->beg is 0-based.
- intv->beg = intv->end = strtol(str->s + b, &s, 0);
- if (!(idx->conf.preset&TI_FLAG_UCSC)) --intv->beg;
- else ++intv->end;
- if (intv->beg < 0) intv->beg = 0;
- if (intv->end < 1) intv->end = 1;
- } else {
- if ((idx->conf.preset&0xffff) == TI_PRESET_GENERIC) {
- if (id == idx->conf.ec) intv->end = strtol(str->s + b, &s, 0);
- } else if ((idx->conf.preset&0xffff) == TI_PRESET_SAM) {
- if (id == 6) { // CIGAR
- int l = 0, op;
- char *t;
- for (s = str->s + b; s < str->s + i;) {
- long x = strtol(s, &t, 10);
- op = toupper(*t);
- if (op == 'M' || op == 'D' || op == 'N') l += x;
- s = t + 1;
- }
- if (l == 0) l = 1;
- intv->end = intv->beg + l;
- }
- } else if ((idx->conf.preset&0xffff) == TI_PRESET_VCF) {
- // FIXME: the following is NOT tested and is likely to be buggy
- if (id == 5) { // ALT
- char *t;
- int max = 1;
- for (s = str->s + b; s < str->s + i;) {
- if (s[i] == 'D') {
- long x = strtol(s + 1, &t, 10);
- if (x > max) max = x;
- s = t + 1;
- } else ++s;
- }
- intv->end = intv->beg + max;
- }
- }
- }
- b = i + 1;
- ++id;
- }
- }
- if (intv->tid < 0 || intv->beg < 0 || intv->end < 0) return -1;
- intv->bin = ti_reg2bin(intv->beg, intv->end);
- return 0;
-}
-
-/************
- * indexing *
- ************/
-
-// requirement: len <= LEN_MASK
-static inline void insert_offset(khash_t(i) *h, int bin, uint64_t beg, uint64_t end)
-{
- khint_t k;
- ti_binlist_t *l;
- int ret;
- k = kh_put(i, h, bin, &ret);
- l = &kh_value(h, k);
- if (ret) { // not present
- l->m = 1; l->n = 0;
- l->list = (pair64_t*)calloc(l->m, 16);
- }
- if (l->n == l->m) {
- l->m <<= 1;
- l->list = (pair64_t*)realloc(l->list, l->m * 16);
- }
- l->list[l->n].u = beg; l->list[l->n++].v = end;
-}
-
-static inline void insert_offset2(ti_lidx_t *index2, int _beg, int _end, uint64_t offset)
-{
- int i, beg, end;
- beg = _beg >> TAD_LIDX_SHIFT;
- end = (_end - 1) >> TAD_LIDX_SHIFT;
- if (index2->m < end + 1) {
- int old_m = index2->m;
- index2->m = end + 1;
- kroundup32(index2->m);
- index2->offset = (uint64_t*)realloc(index2->offset, index2->m * 8);
- memset(index2->offset + old_m, 0, 8 * (index2->m - old_m));
- }
- if (beg == end) {
- if (index2->offset[beg] == 0) index2->offset[beg] = offset;
- } else {
- for (i = beg; i <= end; ++i)
- if (index2->offset[i] == 0) index2->offset[i] = offset;
- }
- if (index2->n < end + 1) index2->n = end + 1;
-}
-
-static void merge_chunks(ti_index_t *idx)
-{
- khash_t(i) *index;
- int i, l, m;
- khint_t k;
- for (i = 0; i < idx->n; ++i) {
- index = idx->index[i];
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- ti_binlist_t *p;
- if (!kh_exist(index, k)) continue;
- p = &kh_value(index, k);
- m = 0;
- for (l = 1; l < p->n; ++l) {
- if (p->list[m].v>>16 == p->list[l].u>>16) p->list[m].v = p->list[l].v;
- else p->list[++m] = p->list[l];
- } // ~for(l)
- p->n = m + 1;
- } // ~for(k)
- } // ~for(i)
-}
-
-static void fill_missing(ti_index_t *idx)
-{
- int i, j;
- for (i = 0; i < idx->n; ++i) {
- ti_lidx_t *idx2 = &idx->index2[i];
- for (j = 1; j < idx2->n; ++j)
- if (idx2->offset[j] == 0)
- idx2->offset[j] = idx2->offset[j-1];
- }
-}
-
-ti_index_t *ti_index_core(BGZF *fp, const ti_conf_t *conf)
-{
- int ret;
- ti_index_t *idx;
- uint32_t last_bin, save_bin;
- int32_t last_coor, last_tid, save_tid;
- uint64_t save_off, last_off, lineno = 0;
- kstring_t *str;
-
- str = calloc(1, sizeof(kstring_t));
-
- idx = (ti_index_t*)calloc(1, sizeof(ti_index_t));
- idx->conf = *conf;
- idx->n = idx->max = 0;
- idx->tname = kh_init(s);
- idx->index = 0;
- idx->index2 = 0;
-
- save_bin = save_tid = last_tid = last_bin = 0xffffffffu;
- save_off = last_off = bgzf_tell(fp); last_coor = 0xffffffffu;
- while ((ret = ti_readline(fp, str)) >= 0) {
- ti_intv_t intv;
- ++lineno;
- if (lineno <= idx->conf.line_skip || str->s[0] == idx->conf.meta_char) {
- last_off = bgzf_tell(fp);
- continue;
- }
- get_intv(idx, str, &intv);
- if (last_tid != intv.tid) { // change of chromosomes
- last_tid = intv.tid;
- last_bin = 0xffffffffu;
- } else if (last_coor > intv.beg) {
- fprintf(stderr, "[ti_index_core] the file out of order at line %llu\n", (unsigned long long)lineno);
- exit(1);
- }
- insert_offset2(&idx->index2[intv.tid], intv.beg, intv.end, last_off);
- if (intv.bin != last_bin) { // then possibly write the binning index
- if (save_bin != 0xffffffffu) // save_bin==0xffffffffu only happens to the first record
- insert_offset(idx->index[save_tid], save_bin, save_off, last_off);
- save_off = last_off;
- save_bin = last_bin = intv.bin;
- save_tid = intv.tid;
- if (save_tid < 0) break;
- }
- if (bgzf_tell(fp) <= last_off) {
- fprintf(stderr, "[ti_index_core] bug in BGZF: %llx < %llx\n",
- (unsigned long long)bgzf_tell(fp), (unsigned long long)last_off);
- exit(1);
- }
- last_off = bgzf_tell(fp);
- last_coor = intv.beg;
- }
- if (save_tid >= 0) insert_offset(idx->index[save_tid], save_bin, save_off, bgzf_tell(fp));
- merge_chunks(idx);
- fill_missing(idx);
-
- free(str->s); free(str);
- return idx;
-}
-
-void ti_index_destroy(ti_index_t *idx)
-{
- khint_t k;
- int i;
- if (idx == 0) return;
- // destroy the name hash table
- for (k = kh_begin(idx->tname); k != kh_end(idx->tname); ++k) {
- if (kh_exist(idx->tname, k))
- free((char*)kh_key(idx->tname, k));
- }
- kh_destroy(s, idx->tname);
- // destroy the binning index
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index = idx->index[i];
- ti_lidx_t *index2 = idx->index2 + i;
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- if (kh_exist(index, k))
- free(kh_value(index, k).list);
- }
- kh_destroy(i, index);
- free(index2->offset);
- }
- free(idx->index);
- // destroy the linear index
- free(idx->index2);
- free(idx);
-}
-
-/******************
- * index file I/O *
- ******************/
-
-void ti_index_save(const ti_index_t *idx, BGZF *fp)
-{
- int32_t i, size, ti_is_be;
- khint_t k;
- ti_is_be = bam_is_big_endian();
- bgzf_write(fp, "TBI\1", 4);
- if (ti_is_be) {
- uint32_t x = idx->n;
- bgzf_write(fp, bam_swap_endian_4p(&x), 4);
- } else bgzf_write(fp, &idx->n, 4);
- assert(sizeof(ti_conf_t) == 24);
- if (ti_is_be) { // write ti_conf_t;
- uint32_t x[6];
- memcpy(x, &idx->conf, 24);
- for (i = 0; i < 6; ++i) bgzf_write(fp, bam_swap_endian_4p(&x[i]), 4);
- } else bgzf_write(fp, &idx->conf, sizeof(ti_conf_t));
- { // write target names
- char **name;
- int32_t l = 0;
- name = calloc(kh_size(idx->tname), sizeof(void*));
- for (k = kh_begin(idx->tname); k != kh_end(idx->tname); ++k)
- if (kh_exist(idx->tname, k))
- name[kh_value(idx->tname, k)] = (char*)kh_key(idx->tname, k);
- for (i = 0; i < kh_size(idx->tname); ++i)
- l += strlen(name[i]) + 1;
- if (ti_is_be) bgzf_write(fp, bam_swap_endian_4p(&l), 4);
- else bgzf_write(fp, &l, 4);
- for (i = 0; i < kh_size(idx->tname); ++i)
- bgzf_write(fp, name[i], strlen(name[i]) + 1);
- free(name);
- }
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index = idx->index[i];
- ti_lidx_t *index2 = idx->index2 + i;
- // write binning index
- size = kh_size(index);
- if (ti_is_be) { // big endian
- uint32_t x = size;
- bgzf_write(fp, bam_swap_endian_4p(&x), 4);
- } else bgzf_write(fp, &size, 4);
- for (k = kh_begin(index); k != kh_end(index); ++k) {
- if (kh_exist(index, k)) {
- ti_binlist_t *p = &kh_value(index, k);
- if (ti_is_be) { // big endian
- uint32_t x;
- x = kh_key(index, k); bgzf_write(fp, bam_swap_endian_4p(&x), 4);
- x = p->n; bgzf_write(fp, bam_swap_endian_4p(&x), 4);
- for (x = 0; (int)x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- bgzf_write(fp, p->list, 16 * p->n);
- for (x = 0; (int)x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- } else {
- bgzf_write(fp, &kh_key(index, k), 4);
- bgzf_write(fp, &p->n, 4);
- bgzf_write(fp, p->list, 16 * p->n);
- }
- }
- }
- // write linear index (index2)
- if (ti_is_be) {
- int x = index2->n;
- bgzf_write(fp, bam_swap_endian_4p(&x), 4);
- } else bgzf_write(fp, &index2->n, 4);
- if (ti_is_be) { // big endian
- int x;
- for (x = 0; (int)x < index2->n; ++x)
- bam_swap_endian_8p(&index2->offset[x]);
- bgzf_write(fp, index2->offset, 8 * index2->n);
- for (x = 0; (int)x < index2->n; ++x)
- bam_swap_endian_8p(&index2->offset[x]);
- } else bgzf_write(fp, index2->offset, 8 * index2->n);
- }
-}
-
-static ti_index_t *ti_index_load_core(BGZF *fp)
-{
- int i, ti_is_be;
- char magic[4];
- ti_index_t *idx;
- ti_is_be = bam_is_big_endian();
- if (fp == 0) {
- fprintf(stderr, "[ti_index_load_core] fail to load index.\n");
- return 0;
- }
- bgzf_read(fp, magic, 4);
- if (strncmp(magic, "TBI\1", 4)) {
- fprintf(stderr, "[ti_index_load] wrong magic number.\n");
- return 0;
- }
- idx = (ti_index_t*)calloc(1, sizeof(ti_index_t));
- bgzf_read(fp, &idx->n, 4);
- if (ti_is_be) bam_swap_endian_4p(&idx->n);
- idx->tname = kh_init(s);
- idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
- idx->index2 = (ti_lidx_t*)calloc(idx->n, sizeof(ti_lidx_t));
- // read idx->conf
- bgzf_read(fp, &idx->conf, sizeof(ti_conf_t));
- if (ti_is_be) {
- bam_swap_endian_4p(&idx->conf.preset);
- bam_swap_endian_4p(&idx->conf.sc);
- bam_swap_endian_4p(&idx->conf.bc);
- bam_swap_endian_4p(&idx->conf.ec);
- bam_swap_endian_4p(&idx->conf.meta_char);
- bam_swap_endian_4p(&idx->conf.line_skip);
- }
- { // read target names
- int j, ret;
- kstring_t *str;
- int32_t l;
- uint8_t *buf;
- bgzf_read(fp, &l, 4);
- if (ti_is_be) bam_swap_endian_4p(&l);
- buf = calloc(l, 1);
- bgzf_read(fp, buf, l);
- str = calloc(1, sizeof(kstring_t));
- for (i = j = 0; i < l; ++i) {
- if (buf[i] == 0) {
- khint_t k = kh_put(s, idx->tname, strdup(str->s), &ret);
- kh_value(idx->tname, k) = j++;
- str->l = 0;
- } else kputc(buf[i], str);
- }
- free(str->s); free(str); free(buf);
- }
- for (i = 0; i < idx->n; ++i) {
- khash_t(i) *index;
- ti_lidx_t *index2 = idx->index2 + i;
- uint32_t key, size;
- khint_t k;
- int j, ret;
- ti_binlist_t *p;
- index = idx->index[i] = kh_init(i);
- // load binning index
- bgzf_read(fp, &size, 4);
- if (ti_is_be) bam_swap_endian_4p(&size);
- for (j = 0; j < (int)size; ++j) {
- bgzf_read(fp, &key, 4);
- if (ti_is_be) bam_swap_endian_4p(&key);
- k = kh_put(i, index, key, &ret);
- p = &kh_value(index, k);
- bgzf_read(fp, &p->n, 4);
- if (ti_is_be) bam_swap_endian_4p(&p->n);
- p->m = p->n;
- p->list = (pair64_t*)malloc(p->m * 16);
- bgzf_read(fp, p->list, 16 * p->n);
- if (ti_is_be) {
- int x;
- for (x = 0; x < p->n; ++x) {
- bam_swap_endian_8p(&p->list[x].u);
- bam_swap_endian_8p(&p->list[x].v);
- }
- }
- }
- // load linear index
- bgzf_read(fp, &index2->n, 4);
- if (ti_is_be) bam_swap_endian_4p(&index2->n);
- index2->m = index2->n;
- index2->offset = (uint64_t*)calloc(index2->m, 8);
- bgzf_read(fp, index2->offset, index2->n * 8);
- if (ti_is_be)
- for (j = 0; j < index2->n; ++j) bam_swap_endian_8p(&index2->offset[j]);
- }
- return idx;
-}
-
-ti_index_t *ti_index_load_local(const char *fnidx)
-{
- BGZF *fp;
- fp = bgzf_open(fnidx, "r");
- if (fp) {
- ti_index_t *idx = ti_index_load_core(fp);
- bgzf_close(fp);
- return idx;
- } else return 0;
-}
-
-#ifdef _USE_KNETFILE
-static void download_from_remote(const char *url)
-{
- const int buf_size = 1 * 1024 * 1024;
- char *fn;
- FILE *fp;
- uint8_t *buf;
- knetFile *fp_remote;
- int l;
- if (strstr(url, "ftp://") != url && strstr(url, "http://") != url) return;
- l = strlen(url);
- for (fn = (char*)url + l - 1; fn >= url; --fn)
- if (*fn == '/') break;
- ++fn; // fn now points to the file name
- fp_remote = knet_open(url, "r");
- if (fp_remote == 0) {
- fprintf(stderr, "[download_from_remote] fail to open remote file.\n");
- return;
- }
- if ((fp = fopen(fn, "w")) == 0) {
- fprintf(stderr, "[download_from_remote] fail to create file in the working directory.\n");
- knet_close(fp_remote);
- return;
- }
- buf = (uint8_t*)calloc(buf_size, 1);
- while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
- fwrite(buf, 1, l, fp);
- free(buf);
- fclose(fp);
- knet_close(fp_remote);
-}
-#else
-static void download_from_remote(const char *url)
-{
- return;
-}
-#endif
-
-static char *get_local_version(const char *fn)
-{
- struct stat sbuf;
- char *fnidx = (char*)calloc(strlen(fn) + 5, 1);
- strcat(strcpy(fnidx, fn), ".tbi");
- if ((strstr(fnidx, "ftp://") == fnidx || strstr(fnidx, "http://") == fnidx)) {
- char *p, *url;
- int l = strlen(fnidx);
- for (p = fnidx + l - 1; p >= fnidx; --p)
- if (*p == '/') break;
- url = fnidx; fnidx = strdup(p + 1);
- if (stat(fnidx, &sbuf) == 0) {
- free(url);
- return fnidx;
- }
- fprintf(stderr, "[%s] downloading the index file...\n", __func__);
- download_from_remote(url);
- free(url);
- }
- if (stat(fnidx, &sbuf) == 0) return fnidx;
- free(fnidx); return 0;
-}
-
-const char **ti_seqname(const ti_index_t *idx, int *n)
-{
- const char **names;
- khint_t k;
- *n = idx->n;
- names = calloc(idx->n, sizeof(void*));
- for (k = kh_begin(idx->tname); k < kh_end(idx->tname); ++k)
- if (kh_exist(idx->tname, k))
- names[kh_val(idx->tname, k)] = kh_key(idx->tname, k);
- return names;
-}
-
-ti_index_t *ti_index_load(const char *fn)
-{
- ti_index_t *idx;
- char *fname = get_local_version(fn);
- if (fname == 0) return 0;
- idx = ti_index_load_local(fname);
- free(fname);
- if (idx == 0) fprintf(stderr, "[ti_index_load] fail to load BAM index.\n");
- return idx;
-}
-
-int ti_index_build2(const char *fn, const ti_conf_t *conf, const char *_fnidx)
-{
- char *fnidx;
- BGZF *fp, *fpidx;
- ti_index_t *idx;
- if ((fp = bgzf_open(fn, "r")) == 0) {
- fprintf(stderr, "[ti_index_build2] fail to open the BAM file.\n");
- return -1;
- }
- idx = ti_index_core(fp, conf);
- bgzf_close(fp);
- if (_fnidx == 0) {
- fnidx = (char*)calloc(strlen(fn) + 5, 1);
- strcpy(fnidx, fn); strcat(fnidx, ".tbi");
- } else fnidx = strdup(_fnidx);
- fpidx = bgzf_open(fnidx, "w");
- if (fpidx == 0) {
- fprintf(stderr, "[ti_index_build2] fail to create the index file.\n");
- free(fnidx);
- return -1;
- }
- ti_index_save(idx, fpidx);
- ti_index_destroy(idx);
- bgzf_close(fpidx);
- free(fnidx);
- return 0;
-}
-
-int ti_index_build(const char *fn, const ti_conf_t *conf)
-{
- return ti_index_build2(fn, conf, 0);
-}
-
-/********************************************
- * parse a region in the format chr:beg-end *
- ********************************************/
-
-int ti_get_tid(const ti_index_t *idx, const char *name)
-{
- khiter_t iter;
- const khash_t(s) *h = idx->tname;
- iter = kh_get(s, h, name); /* get the tid */
- if (iter == kh_end(h)) return -1;
- return kh_value(h, iter);
-}
-
-int ti_parse_region(const ti_index_t *idx, const char *str, int *tid, int *begin, int *end)
-{
- char *s, *p;
- int i, l, k;
- l = strlen(str);
- p = s = (char*)malloc(l+1);
- /* squeeze out "," */
- for (i = k = 0; i != l; ++i)
- if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
- s[k] = 0;
- for (i = 0; i != k; ++i) if (s[i] == ':') break;
- s[i] = 0;
- if ((*tid = ti_get_tid(idx, s)) < 0) {
- free(s);
- return -1;
- }
- if (i == k) { /* dump the whole sequence */
- *begin = 0; *end = 1<<29; free(s);
- return 0;
- }
- for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
- *begin = atoi(p);
- if (i < k) {
- p = s + i + 1;
- *end = atoi(p);
- } else *end = 1<<29;
- if (*begin > 0) --*begin;
- free(s);
- if (*begin > *end) return -1;
- return 0;
-}
-
-/*******************************
- * retrieve a specified region *
- *******************************/
-
-#define MAX_BIN 37450 // =(8^6-1)/7+1
-
-static inline int reg2bins(uint32_t beg, uint32_t end, uint16_t list[MAX_BIN])
-{
- int i = 0, k;
- if (beg >= end) return 0;
- if (end >= 1u<<29) end = 1u<<29;
- --end;
- list[i++] = 0;
- for (k = 1 + (beg>>26); k <= 1 + (end>>26); ++k) list[i++] = k;
- for (k = 9 + (beg>>23); k <= 9 + (end>>23); ++k) list[i++] = k;
- for (k = 73 + (beg>>20); k <= 73 + (end>>20); ++k) list[i++] = k;
- for (k = 585 + (beg>>17); k <= 585 + (end>>17); ++k) list[i++] = k;
- for (k = 4681 + (beg>>14); k <= 4681 + (end>>14); ++k) list[i++] = k;
- return i;
-}
-
-ti_iter_t ti_iter_first()
-{
- ti_iter_t iter;
- iter = calloc(1, sizeof(struct __ti_iter_t));
- iter->from_first = 1;
- return iter;
-}
-
-ti_iter_t ti_iter_query(const ti_index_t *idx, int tid, int beg, int end)
-{
- uint16_t *bins;
- int i, n_bins, n_off;
- pair64_t *off;
- khint_t k;
- khash_t(i) *index;
- uint64_t min_off;
- ti_iter_t iter = 0;
-
- if (beg < 0) beg = 0;
- if (end < beg) return 0;
- // initialize the iterator
- iter = calloc(1, sizeof(struct __ti_iter_t));
- iter->idx = idx; iter->tid = tid; iter->beg = beg; iter->end = end; iter->i = -1;
- // random access
- bins = (uint16_t*)calloc(MAX_BIN, 2);
- n_bins = reg2bins(beg, end, bins);
- index = idx->index[tid];
- if (idx->index2[tid].n > 0) {
- min_off = (beg>>TAD_LIDX_SHIFT >= idx->index2[tid].n)? idx->index2[tid].offset[idx->index2[tid].n-1]
- : idx->index2[tid].offset[beg>>TAD_LIDX_SHIFT];
- if (min_off == 0) { // improvement for index files built by tabix prior to 0.1.4
- int n = beg>>TAD_LIDX_SHIFT;
- if (n > idx->index2[tid].n) n = idx->index2[tid].n;
- for (i = n - 1; i >= 0; --i)
- if (idx->index2[tid].offset[i] != 0) break;
- if (i >= 0) min_off = idx->index2[tid].offset[i];
- }
- } else min_off = 0; // tabix 0.1.2 may produce such index files
- for (i = n_off = 0; i < n_bins; ++i) {
- if ((k = kh_get(i, index, bins[i])) != kh_end(index))
- n_off += kh_value(index, k).n;
- }
- if (n_off == 0) {
- free(bins); return iter;
- }
- off = (pair64_t*)calloc(n_off, 16);
- for (i = n_off = 0; i < n_bins; ++i) {
- if ((k = kh_get(i, index, bins[i])) != kh_end(index)) {
- int j;
- ti_binlist_t *p = &kh_value(index, k);
- for (j = 0; j < p->n; ++j)
- if (p->list[j].v > min_off) off[n_off++] = p->list[j];
- }
- }
- free(bins);
- {
- int l;
- ks_introsort(off, n_off, off);
- // resolve completely contained adjacent blocks
- for (i = 1, l = 0; i < n_off; ++i)
- if (off[l].v < off[i].v)
- off[++l] = off[i];
- n_off = l + 1;
- // resolve overlaps between adjacent blocks; this may happen due to the merge in indexing
- for (i = 1; i < n_off; ++i)
- if (off[i-1].v >= off[i].u) off[i-1].v = off[i].u;
- { // merge adjacent blocks
- for (i = 1, l = 0; i < n_off; ++i) {
- if (off[l].v>>16 == off[i].u>>16) off[l].v = off[i].v;
- else off[++l] = off[i];
- }
- n_off = l + 1;
- }
- }
- iter->n_off = n_off; iter->off = off;
- return iter;
-}
-
-const char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
-{
- if (iter->finished) return 0;
- if (iter->from_first) {
- int ret;
- if ((ret = ti_readline(fp, &iter->str)) < 0) {
- iter->finished = 1;
- return 0;
- } else {
- if (len) *len = iter->str.l;
- return iter->str.s;
- }
- }
- if (iter->n_off == 0) return 0;
- while (1) {
- int ret;
- if (iter->curr_off == 0 || iter->curr_off >= iter->off[iter->i].v) { // then jump to the next chunk
- if (iter->i == iter->n_off - 1) break; // no more chunks
- if (iter->i >= 0) assert(iter->curr_off == iter->off[iter->i].v); // otherwise bug
- if (iter->i < 0 || iter->off[iter->i].v != iter->off[iter->i+1].u) { // not adjacent chunks; then seek
- bgzf_seek(fp, iter->off[iter->i+1].u, SEEK_SET);
- iter->curr_off = bgzf_tell(fp);
- }
- ++iter->i;
- }
- if ((ret = ti_readline(fp, &iter->str)) >= 0) {
- ti_intv_t intv;
- iter->curr_off = bgzf_tell(fp);
- if (iter->str.s[0] == iter->idx->conf.meta_char) continue;
- get_intv((ti_index_t*)iter->idx, &iter->str, &intv);
- if (intv.tid != iter->tid || intv.beg >= iter->end) break; // no need to proceed
- else if (intv.end > iter->beg && iter->end > intv.beg) {
- if (len) *len = iter->str.l;
- return iter->str.s;
- }
- } else break; // end of file
- }
- iter->finished = 1;
- return 0;
-}
-
-void ti_iter_destroy(ti_iter_t iter)
-{
- if (iter) {
- free(iter->str.s); free(iter->off);
- free(iter);
- }
-}
-
-int ti_fetch(BGZF *fp, const ti_index_t *idx, int tid, int beg, int end, void *data, ti_fetch_f func)
-{
- ti_iter_t iter;
- const char *s;
- int len;
- iter = ti_iter_query(idx, tid, beg, end);
- while ((s = ti_iter_read(fp, iter, &len)) != 0)
- func(len, s, data);
- ti_iter_destroy(iter);
- return 0;
-}
-
-/*******************
- * High-level APIs *
- *******************/
-
-tabix_t *ti_open(const char *fn, const char *fnidx)
-{
- tabix_t *t;
- BGZF *fp;
- if ((fp = bgzf_open(fn, "r")) == 0) return 0;
- t = calloc(1, sizeof(tabix_t));
- t->fn = strdup(fn);
- if (fnidx) t->fnidx = strdup(fnidx);
- t->fp = fp;
- return t;
-}
-
-void ti_close(tabix_t *t)
-{
- if (t) {
- bgzf_close(t->fp);
- if (t->idx) ti_index_destroy(t->idx);
- free(t->fn); free(t->fnidx);
- free(t);
- }
-}
-
-int ti_lazy_index_load(tabix_t *t)
-{
- if (t->idx == 0) { // load index
- if (t->fnidx) t->idx = ti_index_load_local(t->fnidx);
- else t->idx = ti_index_load(t->fn);
- if (t->idx == 0) return -1; // fail to load index
- }
- return 0;
-}
-
-ti_iter_t ti_queryi(tabix_t *t, int tid, int beg, int end)
-{
- if (tid < 0) return ti_iter_first();
- if (ti_lazy_index_load(t) != 0) return 0;
- return ti_iter_query(t->idx, tid, beg, end);
-}
-
-ti_iter_t ti_querys(tabix_t *t, const char *reg)
-{
- int tid, beg, end;
- if (reg == 0) return ti_iter_first();
- if (ti_lazy_index_load(t) != 0) return 0;
- if (ti_parse_region(t->idx, reg, &tid, &beg, &end) < 0) return 0;
- return ti_iter_query(t->idx, tid, beg, end);
-}
-
-ti_iter_t ti_query(tabix_t *t, const char *name, int beg, int end)
-{
- int tid;
- if (name == 0) return ti_iter_first();
- // then need to load the index
- if (ti_lazy_index_load(t) != 0) return 0;
- if ((tid = ti_get_tid(t->idx, name)) < 0) return 0;
- return ti_iter_query(t->idx, tid, beg, end);
-}
-
-const char *ti_read(tabix_t *t, ti_iter_t iter, int *len)
-{
- return ti_iter_read(t->fp, iter, len);
-}
--- /dev/null
+#include "pysam.h"
+
+#include <ctype.h>
+#include <assert.h>
+#include <sys/stat.h>
+#include "khash.h"
+#include "ksort.h"
+#include "kstring.h"
+#include "bam_endian.h"
+#ifdef _USE_KNETFILE
+#include "knetfile.h"
+#endif
+#include "tabix.h"
+
+#define TAD_MIN_CHUNK_GAP 32768
+// 1<<14 is the size of minimum bin.
+#define TAD_LIDX_SHIFT 14
+
+typedef struct {
+ uint64_t u, v;
+} pair64_t;
+
+#define pair64_lt(a,b) ((a).u < (b).u)
+KSORT_INIT(offt, pair64_t, pair64_lt)
+
+typedef struct {
+ uint32_t m, n;
+ pair64_t *list;
+} ti_binlist_t;
+
+typedef struct {
+ int32_t n, m;
+ uint64_t *offset;
+} ti_lidx_t;
+
+KHASH_MAP_INIT_INT(i, ti_binlist_t)
+KHASH_MAP_INIT_STR(s, int)
+
+struct __ti_index_t {
+ ti_conf_t conf;
+ int32_t n, max;
+ khash_t(s) *tname;
+ khash_t(i) **index;
+ ti_lidx_t *index2;
+};
+
+struct __ti_iter_t {
+ int from_first; // read from the first record; no random access
+ int tid, beg, end, n_off, i, finished;
+ uint64_t curr_off;
+ kstring_t str;
+ const ti_index_t *idx;
+ pair64_t *off;
+};
+
+typedef struct {
+ int tid, beg, end, bin;
+} ti_intv_t;
+
+ti_conf_t ti_conf_gff = { 0, 1, 4, 5, '#', 0 };
+ti_conf_t ti_conf_bed = { TI_FLAG_UCSC, 1, 2, 3, '#', 0 };
+ti_conf_t ti_conf_psltbl = { TI_FLAG_UCSC, 15, 17, 18, '#', 0 };
+ti_conf_t ti_conf_sam = { TI_PRESET_SAM, 3, 4, 0, '@', 0 };
+ti_conf_t ti_conf_vcf = { TI_PRESET_VCF, 1, 2, 0, '#', 0 };
+
+/***************
+ * read a line *
+ ***************/
+
+/*
+int ti_readline(BGZF *fp, kstring_t *str)
+{
+ int c, l = 0;
+ str->l = 0;
+ while ((c = bgzf_getc(fp)) >= 0 && c != '\n') {
+ ++l;
+ if (c != '\r') kputc(c, str);
+ }
+ if (c < 0 && l == 0) return -1; // end of file
+ return str->l;
+}
+*/
+
+/* Below is a faster implementation largely equivalent to the one
+ * commented out above. */
+int ti_readline(BGZF *fp, kstring_t *str)
+{
+ int l, state = 0;
+ unsigned char *buf = (unsigned char*)fp->uncompressed_block;
+ str->l = 0;
+ do {
+ if (fp->block_offset >= fp->block_length) {
+ if (bgzf_read_block(fp) != 0) { state = -2; break; }
+ if (fp->block_length == 0) { state = -1; break; }
+ }
+ for (l = fp->block_offset; l < fp->block_length && buf[l] != '\n'; ++l);
+ if (l < fp->block_length) state = 1;
+ l -= fp->block_offset;
+ if (str->l + l + 1 >= str->m) {
+ str->m = str->l + l + 2;
+ kroundup32(str->m);
+ str->s = (char*)realloc(str->s, str->m);
+ }
+ memcpy(str->s + str->l, buf + fp->block_offset, l);
+ str->l += l;
+ fp->block_offset += l + 1;
+ if (fp->block_offset >= fp->block_length) {
+#ifdef _USE_KNETFILE
+ fp->block_address = knet_tell(fp->x.fpr);
+#else
+ fp->block_address = ftello(fp->file);
+#endif
+ fp->block_offset = 0;
+ fp->block_length = 0;
+ }
+ } while (state == 0);
+ if (str->l == 0 && state < 0) return state;
+ str->s[str->l] = 0;
+ return str->l;
+}
+
+/*************************************
+ * get the interval from a data line *
+ *************************************/
+
+static inline int ti_reg2bin(uint32_t beg, uint32_t end)
+{
+ --end;
+ if (beg>>14 == end>>14) return 4681 + (beg>>14);
+ if (beg>>17 == end>>17) return 585 + (beg>>17);
+ if (beg>>20 == end>>20) return 73 + (beg>>20);
+ if (beg>>23 == end>>23) return 9 + (beg>>23);
+ if (beg>>26 == end>>26) return 1 + (beg>>26);
+ return 0;
+}
+
+static int get_tid(ti_index_t *idx, const char *ss)
+{
+ khint_t k;
+ int tid;
+ k = kh_get(s, idx->tname, ss);
+ if (k == kh_end(idx->tname)) { // a new target sequence
+ int ret, size;
+ // update idx->n, ->max, ->index and ->index2
+ if (idx->n == idx->max) {
+ idx->max = idx->max? idx->max<<1 : 8;
+ idx->index = realloc(idx->index, idx->max * sizeof(void*));
+ idx->index2 = realloc(idx->index2, idx->max * sizeof(ti_lidx_t));
+ }
+ memset(&idx->index2[idx->n], 0, sizeof(ti_lidx_t));
+ idx->index[idx->n++] = kh_init(i);
+ // update ->tname
+ tid = size = kh_size(idx->tname);
+ k = kh_put(s, idx->tname, strdup(ss), &ret);
+ kh_value(idx->tname, k) = size;
+ assert(idx->n == kh_size(idx->tname));
+ } else tid = kh_value(idx->tname, k);
+ return tid;
+}
+
+int ti_get_intv(const ti_conf_t *conf, int len, char *line, ti_interval_t *intv)
+{
+ int i, b = 0, id = 1, ncols = 0;
+ char *s;
+ intv->ss = intv->se = 0; intv->beg = intv->end = -1;
+ for (i = 0; i <= len; ++i) {
+ if (line[i] == '\t' || line[i] == 0) {
+ ++ncols;
+ if (id == conf->sc) {
+ intv->ss = line + b; intv->se = line + i;
+ } else if (id == conf->bc) {
+ // here ->beg is 0-based.
+ intv->beg = intv->end = strtol(line + b, &s, 0);
+ if (!(conf->preset&TI_FLAG_UCSC)) --intv->beg;
+ else ++intv->end;
+ if (intv->beg < 0) intv->beg = 0;
+ if (intv->end < 1) intv->end = 1;
+ } else {
+ if ((conf->preset&0xffff) == TI_PRESET_GENERIC) {
+ if (id == conf->ec) intv->end = strtol(line + b, &s, 0);
+ } else if ((conf->preset&0xffff) == TI_PRESET_SAM) {
+ if (id == 6) { // CIGAR
+ int l = 0, op;
+ char *t;
+ for (s = line + b; s < line + i;) {
+ long x = strtol(s, &t, 10);
+ op = toupper(*t);
+ if (op == 'M' || op == 'D' || op == 'N') l += x;
+ s = t + 1;
+ }
+ if (l == 0) l = 1;
+ intv->end = intv->beg + l;
+ }
+ } else if ((conf->preset&0xffff) == TI_PRESET_VCF) {
+ // FIXME: the following is NOT tested and is likely to be buggy
+ if (id == 4) {
+ if (b < i) intv->end = intv->beg + (i - b);
+ } else if (id == 8) { // look for "END="
+ int c = line[i];
+ line[i] = 0;
+ s = strstr(line + b, "END=");
+ if (s == line + b) s += 4;
+ else if (s) {
+ s = strstr(line + b, ";END=");
+ if (s) s += 5;
+ }
+ if (s) intv->end = strtol(s, &s, 0);
+ line[i] = c;
+ }
+ }
+ }
+ b = i + 1;
+ ++id;
+ }
+ }
+/*
+ if (ncols < conf->sc || ncols < conf->bc || ncols < conf->ec) {
+ if (ncols == 1) fprintf(pysamerr,"[get_intv] Is the file tab-delimited? The line has %d field only: %s\n", ncols, line);
+ else fprintf(pysamerr,"[get_intv] The line has %d field(s) only: %s\n", ncols, line);
+ exit(1);
+ }
+*/
+ if (intv->ss == 0 || intv->se == 0 || intv->beg < 0 || intv->end < 0) return -1;
+ return 0;
+}
+
+static int get_intv(ti_index_t *idx, kstring_t *str, ti_intv_t *intv)
+{
+ ti_interval_t x;
+ intv->tid = intv->beg = intv->end = intv->bin = -1;
+ if (ti_get_intv(&idx->conf, str->l, str->s, &x) == 0) {
+ int c = *x.se;
+ *x.se = '\0'; intv->tid = get_tid(idx, x.ss); *x.se = c;
+ intv->beg = x.beg; intv->end = x.end;
+ intv->bin = ti_reg2bin(intv->beg, intv->end);
+ return (intv->tid >= 0 && intv->beg >= 0 && intv->end >= 0)? 0 : -1;
+ } else {
+ fprintf(pysamerr, "[%s] the following line cannot be parsed and skipped: %s\n", __func__, str->s);
+ return -1;
+ }
+}
+
+/************
+ * indexing *
+ ************/
+
+// requirement: len <= LEN_MASK
+static inline void insert_offset(khash_t(i) *h, int bin, uint64_t beg, uint64_t end)
+{
+ khint_t k;
+ ti_binlist_t *l;
+ int ret;
+ k = kh_put(i, h, bin, &ret);
+ l = &kh_value(h, k);
+ if (ret) { // not present
+ l->m = 1; l->n = 0;
+ l->list = (pair64_t*)calloc(l->m, 16);
+ }
+ if (l->n == l->m) {
+ l->m <<= 1;
+ l->list = (pair64_t*)realloc(l->list, l->m * 16);
+ }
+ l->list[l->n].u = beg; l->list[l->n++].v = end;
+}
+
+static inline uint64_t insert_offset2(ti_lidx_t *index2, int _beg, int _end, uint64_t offset)
+{
+ int i, beg, end;
+ beg = _beg >> TAD_LIDX_SHIFT;
+ end = (_end - 1) >> TAD_LIDX_SHIFT;
+ if (index2->m < end + 1) {
+ int old_m = index2->m;
+ index2->m = end + 1;
+ kroundup32(index2->m);
+ index2->offset = (uint64_t*)realloc(index2->offset, index2->m * 8);
+ memset(index2->offset + old_m, 0, 8 * (index2->m - old_m));
+ }
+ if (beg == end) {
+ if (index2->offset[beg] == 0) index2->offset[beg] = offset;
+ } else {
+ for (i = beg; i <= end; ++i)
+ if (index2->offset[i] == 0) index2->offset[i] = offset;
+ }
+ if (index2->n < end + 1) index2->n = end + 1;
+ return (uint64_t)beg<<32 | end;
+}
+
+static void merge_chunks(ti_index_t *idx)
+{
+ khash_t(i) *index;
+ int i, l, m;
+ khint_t k;
+ for (i = 0; i < idx->n; ++i) {
+ index = idx->index[i];
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ ti_binlist_t *p;
+ if (!kh_exist(index, k)) continue;
+ p = &kh_value(index, k);
+ m = 0;
+ for (l = 1; l < p->n; ++l) {
+ if (p->list[m].v>>16 == p->list[l].u>>16) p->list[m].v = p->list[l].v;
+ else p->list[++m] = p->list[l];
+ } // ~for(l)
+ p->n = m + 1;
+ } // ~for(k)
+ } // ~for(i)
+}
+
+static void fill_missing(ti_index_t *idx)
+{
+ int i, j;
+ for (i = 0; i < idx->n; ++i) {
+ ti_lidx_t *idx2 = &idx->index2[i];
+ for (j = 1; j < idx2->n; ++j)
+ if (idx2->offset[j] == 0)
+ idx2->offset[j] = idx2->offset[j-1];
+ }
+}
+
+ti_index_t *ti_index_core(BGZF *fp, const ti_conf_t *conf)
+{
+ int ret;
+ ti_index_t *idx;
+ uint32_t last_bin, save_bin;
+ int32_t last_coor, last_tid, save_tid;
+ uint64_t save_off, last_off, lineno = 0, offset0 = (uint64_t)-1, tmp;
+ kstring_t *str;
+
+ str = calloc(1, sizeof(kstring_t));
+
+ idx = (ti_index_t*)calloc(1, sizeof(ti_index_t));
+ idx->conf = *conf;
+ idx->n = idx->max = 0;
+ idx->tname = kh_init(s);
+ idx->index = 0;
+ idx->index2 = 0;
+
+ save_bin = save_tid = last_tid = last_bin = 0xffffffffu;
+ save_off = last_off = bgzf_tell(fp); last_coor = 0xffffffffu;
+ while ((ret = ti_readline(fp, str)) >= 0) {
+ ti_intv_t intv;
+ ++lineno;
+ if (lineno <= idx->conf.line_skip || str->s[0] == idx->conf.meta_char) {
+ last_off = bgzf_tell(fp);
+ continue;
+ }
+ get_intv(idx, str, &intv);
+ if ( intv.beg<0 || intv.end<0 )
+ {
+ fprintf(pysamerr,"[ti_index_core] the indexes overlap or are out of bounds\n");
+ exit(1);
+ }
+ if (last_tid != intv.tid) { // change of chromosomes
+ if (last_tid>intv.tid )
+ {
+ fprintf(pysamerr,"[ti_index_core] the chromosome blocks not continuous at line %llu, is the file sorted? [pos %d]\n",(unsigned long long)lineno,intv.beg+1);
+ exit(1);
+ }
+ last_tid = intv.tid;
+ last_bin = 0xffffffffu;
+ } else if (last_coor > intv.beg) {
+ fprintf(pysamerr, "[ti_index_core] the file out of order at line %llu\n", (unsigned long long)lineno);
+ exit(1);
+ }
+ tmp = insert_offset2(&idx->index2[intv.tid], intv.beg, intv.end, last_off);
+ if (last_off == 0) offset0 = tmp;
+ if (intv.bin != last_bin) { // then possibly write the binning index
+ if (save_bin != 0xffffffffu) // save_bin==0xffffffffu only happens to the first record
+ insert_offset(idx->index[save_tid], save_bin, save_off, last_off);
+ save_off = last_off;
+ save_bin = last_bin = intv.bin;
+ save_tid = intv.tid;
+ if (save_tid < 0) break;
+ }
+ if (bgzf_tell(fp) <= last_off) {
+ fprintf(pysamerr, "[ti_index_core] bug in BGZF: %llx < %llx\n",
+ (unsigned long long)bgzf_tell(fp), (unsigned long long)last_off);
+ exit(1);
+ }
+ last_off = bgzf_tell(fp);
+ last_coor = intv.beg;
+ }
+ if (save_tid >= 0) insert_offset(idx->index[save_tid], save_bin, save_off, bgzf_tell(fp));
+ merge_chunks(idx);
+ fill_missing(idx);
+ if (offset0 != (uint64_t)-1 && idx->n && idx->index2[0].offset) {
+ int i, beg = offset0>>32, end = offset0&0xffffffffu;
+ for (i = beg; i <= end; ++i) idx->index2[0].offset[i] = 0;
+ }
+
+ free(str->s); free(str);
+ return idx;
+}
+
+void ti_index_destroy(ti_index_t *idx)
+{
+ khint_t k;
+ int i;
+ if (idx == 0) return;
+ // destroy the name hash table
+ for (k = kh_begin(idx->tname); k != kh_end(idx->tname); ++k) {
+ if (kh_exist(idx->tname, k))
+ free((char*)kh_key(idx->tname, k));
+ }
+ kh_destroy(s, idx->tname);
+ // destroy the binning index
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index = idx->index[i];
+ ti_lidx_t *index2 = idx->index2 + i;
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ if (kh_exist(index, k))
+ free(kh_value(index, k).list);
+ }
+ kh_destroy(i, index);
+ free(index2->offset);
+ }
+ free(idx->index);
+ // destroy the linear index
+ free(idx->index2);
+ free(idx);
+}
+
+/******************
+ * index file I/O *
+ ******************/
+
+void ti_index_save(const ti_index_t *idx, BGZF *fp)
+{
+ int32_t i, size, ti_is_be;
+ khint_t k;
+ ti_is_be = bam_is_big_endian();
+ bgzf_write(fp, "TBI\1", 4);
+ if (ti_is_be) {
+ uint32_t x = idx->n;
+ bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ } else bgzf_write(fp, &idx->n, 4);
+ assert(sizeof(ti_conf_t) == 24);
+ if (ti_is_be) { // write ti_conf_t;
+ uint32_t x[6];
+ memcpy(x, &idx->conf, 24);
+ for (i = 0; i < 6; ++i) bgzf_write(fp, bam_swap_endian_4p(&x[i]), 4);
+ } else bgzf_write(fp, &idx->conf, sizeof(ti_conf_t));
+ { // write target names
+ char **name;
+ int32_t l = 0;
+ name = calloc(kh_size(idx->tname), sizeof(void*));
+ for (k = kh_begin(idx->tname); k != kh_end(idx->tname); ++k)
+ if (kh_exist(idx->tname, k))
+ name[kh_value(idx->tname, k)] = (char*)kh_key(idx->tname, k);
+ for (i = 0; i < kh_size(idx->tname); ++i)
+ l += strlen(name[i]) + 1;
+ if (ti_is_be) bgzf_write(fp, bam_swap_endian_4p(&l), 4);
+ else bgzf_write(fp, &l, 4);
+ for (i = 0; i < kh_size(idx->tname); ++i)
+ bgzf_write(fp, name[i], strlen(name[i]) + 1);
+ free(name);
+ }
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index = idx->index[i];
+ ti_lidx_t *index2 = idx->index2 + i;
+ // write binning index
+ size = kh_size(index);
+ if (ti_is_be) { // big endian
+ uint32_t x = size;
+ bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ } else bgzf_write(fp, &size, 4);
+ for (k = kh_begin(index); k != kh_end(index); ++k) {
+ if (kh_exist(index, k)) {
+ ti_binlist_t *p = &kh_value(index, k);
+ if (ti_is_be) { // big endian
+ uint32_t x;
+ x = kh_key(index, k); bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ x = p->n; bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ for (x = 0; (int)x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ bgzf_write(fp, p->list, 16 * p->n);
+ for (x = 0; (int)x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ } else {
+ bgzf_write(fp, &kh_key(index, k), 4);
+ bgzf_write(fp, &p->n, 4);
+ bgzf_write(fp, p->list, 16 * p->n);
+ }
+ }
+ }
+ // write linear index (index2)
+ if (ti_is_be) {
+ int x = index2->n;
+ bgzf_write(fp, bam_swap_endian_4p(&x), 4);
+ } else bgzf_write(fp, &index2->n, 4);
+ if (ti_is_be) { // big endian
+ int x;
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ bgzf_write(fp, index2->offset, 8 * index2->n);
+ for (x = 0; (int)x < index2->n; ++x)
+ bam_swap_endian_8p(&index2->offset[x]);
+ } else bgzf_write(fp, index2->offset, 8 * index2->n);
+ }
+}
+
+static ti_index_t *ti_index_load_core(BGZF *fp)
+{
+ int i, ti_is_be;
+ char magic[4];
+ ti_index_t *idx;
+ ti_is_be = bam_is_big_endian();
+ if (fp == 0) {
+ fprintf(pysamerr, "[ti_index_load_core] fail to load index.\n");
+ return 0;
+ }
+ bgzf_read(fp, magic, 4);
+ if (strncmp(magic, "TBI\1", 4)) {
+ fprintf(pysamerr, "[ti_index_load] wrong magic number.\n");
+ return 0;
+ }
+ idx = (ti_index_t*)calloc(1, sizeof(ti_index_t));
+ bgzf_read(fp, &idx->n, 4);
+ if (ti_is_be) bam_swap_endian_4p(&idx->n);
+ idx->tname = kh_init(s);
+ idx->index = (khash_t(i)**)calloc(idx->n, sizeof(void*));
+ idx->index2 = (ti_lidx_t*)calloc(idx->n, sizeof(ti_lidx_t));
+ // read idx->conf
+ bgzf_read(fp, &idx->conf, sizeof(ti_conf_t));
+ if (ti_is_be) {
+ bam_swap_endian_4p(&idx->conf.preset);
+ bam_swap_endian_4p(&idx->conf.sc);
+ bam_swap_endian_4p(&idx->conf.bc);
+ bam_swap_endian_4p(&idx->conf.ec);
+ bam_swap_endian_4p(&idx->conf.meta_char);
+ bam_swap_endian_4p(&idx->conf.line_skip);
+ }
+ { // read target names
+ int j, ret;
+ kstring_t *str;
+ int32_t l;
+ uint8_t *buf;
+ bgzf_read(fp, &l, 4);
+ if (ti_is_be) bam_swap_endian_4p(&l);
+ buf = calloc(l, 1);
+ bgzf_read(fp, buf, l);
+ str = calloc(1, sizeof(kstring_t));
+ for (i = j = 0; i < l; ++i) {
+ if (buf[i] == 0) {
+ khint_t k = kh_put(s, idx->tname, strdup(str->s), &ret);
+ kh_value(idx->tname, k) = j++;
+ str->l = 0;
+ } else kputc(buf[i], str);
+ }
+ free(str->s); free(str); free(buf);
+ }
+ for (i = 0; i < idx->n; ++i) {
+ khash_t(i) *index;
+ ti_lidx_t *index2 = idx->index2 + i;
+ uint32_t key, size;
+ khint_t k;
+ int j, ret;
+ ti_binlist_t *p;
+ index = idx->index[i] = kh_init(i);
+ // load binning index
+ bgzf_read(fp, &size, 4);
+ if (ti_is_be) bam_swap_endian_4p(&size);
+ for (j = 0; j < (int)size; ++j) {
+ bgzf_read(fp, &key, 4);
+ if (ti_is_be) bam_swap_endian_4p(&key);
+ k = kh_put(i, index, key, &ret);
+ p = &kh_value(index, k);
+ bgzf_read(fp, &p->n, 4);
+ if (ti_is_be) bam_swap_endian_4p(&p->n);
+ p->m = p->n;
+ p->list = (pair64_t*)malloc(p->m * 16);
+ bgzf_read(fp, p->list, 16 * p->n);
+ if (ti_is_be) {
+ int x;
+ for (x = 0; x < p->n; ++x) {
+ bam_swap_endian_8p(&p->list[x].u);
+ bam_swap_endian_8p(&p->list[x].v);
+ }
+ }
+ }
+ // load linear index
+ bgzf_read(fp, &index2->n, 4);
+ if (ti_is_be) bam_swap_endian_4p(&index2->n);
+ index2->m = index2->n;
+ index2->offset = (uint64_t*)calloc(index2->m, 8);
+ bgzf_read(fp, index2->offset, index2->n * 8);
+ if (ti_is_be)
+ for (j = 0; j < index2->n; ++j) bam_swap_endian_8p(&index2->offset[j]);
+ }
+ return idx;
+}
+
+ti_index_t *ti_index_load_local(const char *fnidx)
+{
+ BGZF *fp;
+ fp = bgzf_open(fnidx, "r");
+ if (fp) {
+ ti_index_t *idx = ti_index_load_core(fp);
+ bgzf_close(fp);
+ return idx;
+ } else return 0;
+}
+
+#ifdef _USE_KNETFILE
+static void download_from_remote(const char *url)
+{
+ const int buf_size = 1 * 1024 * 1024;
+ char *fn;
+ FILE *fp;
+ uint8_t *buf;
+ knetFile *fp_remote;
+ int l;
+ if (strstr(url, "ftp://") != url && strstr(url, "http://") != url) return;
+ l = strlen(url);
+ for (fn = (char*)url + l - 1; fn >= url; --fn)
+ if (*fn == '/') break;
+ ++fn; // fn now points to the file name
+ fp_remote = knet_open(url, "r");
+ if (fp_remote == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to open remote file.\n");
+ return;
+ }
+ if ((fp = fopen(fn, "w")) == 0) {
+ fprintf(pysamerr, "[download_from_remote] fail to create file in the working directory.\n");
+ knet_close(fp_remote);
+ return;
+ }
+ buf = (uint8_t*)calloc(buf_size, 1);
+ while ((l = knet_read(fp_remote, buf, buf_size)) != 0)
+ fwrite(buf, 1, l, fp);
+ free(buf);
+ fclose(fp);
+ knet_close(fp_remote);
+}
+#else
+static void download_from_remote(const char *url)
+{
+ return;
+}
+#endif
+
+static char *get_local_version(const char *fn)
+{
+ struct stat sbuf;
+ char *fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcat(strcpy(fnidx, fn), ".tbi");
+ if ((strstr(fnidx, "ftp://") == fnidx || strstr(fnidx, "http://") == fnidx)) {
+ char *p, *url;
+ int l = strlen(fnidx);
+ for (p = fnidx + l - 1; p >= fnidx; --p)
+ if (*p == '/') break;
+ url = fnidx; fnidx = strdup(p + 1);
+ if (stat(fnidx, &sbuf) == 0) {
+ free(url);
+ return fnidx;
+ }
+ fprintf(pysamerr, "[%s] downloading the index file...\n", __func__);
+ download_from_remote(url);
+ free(url);
+ }
+ if (stat(fnidx, &sbuf) == 0) return fnidx;
+ free(fnidx); return 0;
+}
+
+const char **ti_seqname(const ti_index_t *idx, int *n)
+{
+ const char **names;
+ khint_t k;
+ *n = idx->n;
+ names = calloc(idx->n, sizeof(void*));
+ for (k = kh_begin(idx->tname); k < kh_end(idx->tname); ++k)
+ if (kh_exist(idx->tname, k))
+ names[kh_val(idx->tname, k)] = kh_key(idx->tname, k);
+ return names;
+}
+
+ti_index_t *ti_index_load(const char *fn)
+{
+ ti_index_t *idx;
+ char *fname = get_local_version(fn);
+ if (fname == 0) return 0;
+ idx = ti_index_load_local(fname);
+ if (idx == 0) fprintf(pysamerr, "[ti_index_load] fail to load the index: %s\n", fname);
+ free(fname);
+ return idx;
+}
+
+int ti_index_build2(const char *fn, const ti_conf_t *conf, const char *_fnidx)
+{
+ char *fnidx;
+ BGZF *fp, *fpidx;
+ ti_index_t *idx;
+ if ((fp = bgzf_open(fn, "r")) == 0) {
+ fprintf(pysamerr, "[ti_index_build2] fail to open the file: %s\n", fn);
+ return -1;
+ }
+ idx = ti_index_core(fp, conf);
+ bgzf_close(fp);
+ if (_fnidx == 0) {
+ fnidx = (char*)calloc(strlen(fn) + 5, 1);
+ strcpy(fnidx, fn); strcat(fnidx, ".tbi");
+ } else fnidx = strdup(_fnidx);
+ fpidx = bgzf_open(fnidx, "w");
+ if (fpidx == 0) {
+ fprintf(pysamerr, "[ti_index_build2] fail to create the index file.\n");
+ free(fnidx);
+ return -1;
+ }
+ ti_index_save(idx, fpidx);
+ ti_index_destroy(idx);
+ bgzf_close(fpidx);
+ free(fnidx);
+ return 0;
+}
+
+int ti_index_build(const char *fn, const ti_conf_t *conf)
+{
+ return ti_index_build2(fn, conf, 0);
+}
+
+/********************************************
+ * parse a region in the format chr:beg-end *
+ ********************************************/
+
+int ti_get_tid(const ti_index_t *idx, const char *name)
+{
+ khiter_t iter;
+ const khash_t(s) *h = idx->tname;
+ iter = kh_get(s, h, name); /* get the tid */
+ if (iter == kh_end(h)) return -1;
+ return kh_value(h, iter);
+}
+
+int ti_parse_region(const ti_index_t *idx, const char *str, int *tid, int *begin, int *end)
+{
+ char *s, *p;
+ int i, l, k;
+ l = strlen(str);
+ p = s = (char*)malloc(l+1);
+ /* squeeze out "," */
+ for (i = k = 0; i != l; ++i)
+ if (str[i] != ',' && !isspace(str[i])) s[k++] = str[i];
+ s[k] = 0;
+ for (i = 0; i != k; ++i) if (s[i] == ':') break;
+ s[i] = 0;
+ if ((*tid = ti_get_tid(idx, s)) < 0) {
+ free(s);
+ return -1;
+ }
+ if (i == k) { /* dump the whole sequence */
+ *begin = 0; *end = 1<<29; free(s);
+ return 0;
+ }
+ for (p = s + i + 1; i != k; ++i) if (s[i] == '-') break;
+ *begin = atoi(p);
+ if (i < k) {
+ p = s + i + 1;
+ *end = atoi(p);
+ } else *end = 1<<29;
+ if (*begin > 0) --*begin;
+ free(s);
+ if (*begin > *end) return -1;
+ return 0;
+}
+
+/*******************************
+ * retrieve a specified region *
+ *******************************/
+
+#define MAX_BIN 37450 // =(8^6-1)/7+1
+
+static inline int reg2bins(uint32_t beg, uint32_t end, uint16_t list[MAX_BIN])
+{
+ int i = 0, k;
+ if (beg >= end) return 0;
+ if (end >= 1u<<29) end = 1u<<29;
+ --end;
+ list[i++] = 0;
+ for (k = 1 + (beg>>26); k <= 1 + (end>>26); ++k) list[i++] = k;
+ for (k = 9 + (beg>>23); k <= 9 + (end>>23); ++k) list[i++] = k;
+ for (k = 73 + (beg>>20); k <= 73 + (end>>20); ++k) list[i++] = k;
+ for (k = 585 + (beg>>17); k <= 585 + (end>>17); ++k) list[i++] = k;
+ for (k = 4681 + (beg>>14); k <= 4681 + (end>>14); ++k) list[i++] = k;
+ return i;
+}
+
+ti_iter_t ti_iter_first()
+{
+ ti_iter_t iter;
+ iter = calloc(1, sizeof(struct __ti_iter_t));
+ iter->from_first = 1;
+ return iter;
+}
+
+ti_iter_t ti_iter_query(const ti_index_t *idx, int tid, int beg, int end)
+{
+ uint16_t *bins;
+ int i, n_bins, n_off;
+ pair64_t *off;
+ khint_t k;
+ khash_t(i) *index;
+ uint64_t min_off;
+ ti_iter_t iter = 0;
+
+ if (beg < 0) beg = 0;
+ if (end < beg) return 0;
+ // initialize the iterator
+ iter = calloc(1, sizeof(struct __ti_iter_t));
+ iter->idx = idx; iter->tid = tid; iter->beg = beg; iter->end = end; iter->i = -1;
+ // random access
+ bins = (uint16_t*)calloc(MAX_BIN, 2);
+ n_bins = reg2bins(beg, end, bins);
+ index = idx->index[tid];
+ if (idx->index2[tid].n > 0) {
+ min_off = (beg>>TAD_LIDX_SHIFT >= idx->index2[tid].n)? idx->index2[tid].offset[idx->index2[tid].n-1]
+ : idx->index2[tid].offset[beg>>TAD_LIDX_SHIFT];
+ if (min_off == 0) { // improvement for index files built by tabix prior to 0.1.4
+ int n = beg>>TAD_LIDX_SHIFT;
+ if (n > idx->index2[tid].n) n = idx->index2[tid].n;
+ for (i = n - 1; i >= 0; --i)
+ if (idx->index2[tid].offset[i] != 0) break;
+ if (i >= 0) min_off = idx->index2[tid].offset[i];
+ }
+ } else min_off = 0; // tabix 0.1.2 may produce such index files
+ for (i = n_off = 0; i < n_bins; ++i) {
+ if ((k = kh_get(i, index, bins[i])) != kh_end(index))
+ n_off += kh_value(index, k).n;
+ }
+ if (n_off == 0) {
+ free(bins); return iter;
+ }
+ off = (pair64_t*)calloc(n_off, 16);
+ for (i = n_off = 0; i < n_bins; ++i) {
+ if ((k = kh_get(i, index, bins[i])) != kh_end(index)) {
+ int j;
+ ti_binlist_t *p = &kh_value(index, k);
+ for (j = 0; j < p->n; ++j)
+ if (p->list[j].v > min_off) off[n_off++] = p->list[j];
+ }
+ }
+ if (n_off == 0) {
+ free(bins); free(off); return iter;
+ }
+ free(bins);
+ {
+ int l;
+ ks_introsort(offt, n_off, off);
+ // resolve completely contained adjacent blocks
+ for (i = 1, l = 0; i < n_off; ++i)
+ if (off[l].v < off[i].v)
+ off[++l] = off[i];
+ n_off = l + 1;
+ // resolve overlaps between adjacent blocks; this may happen due to the merge in indexing
+ for (i = 1; i < n_off; ++i)
+ if (off[i-1].v >= off[i].u) off[i-1].v = off[i].u;
+ { // merge adjacent blocks
+ for (i = 1, l = 0; i < n_off; ++i) {
+ if (off[l].v>>16 == off[i].u>>16) off[l].v = off[i].v;
+ else off[++l] = off[i];
+ }
+ n_off = l + 1;
+ }
+ }
+ iter->n_off = n_off; iter->off = off;
+ return iter;
+}
+
+const char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len)
+{
+ if (iter->finished) return 0;
+ if (iter->from_first) {
+ int ret;
+ if ((ret = ti_readline(fp, &iter->str)) < 0) {
+ iter->finished = 1;
+ return 0;
+ } else {
+ if (len) *len = iter->str.l;
+ return iter->str.s;
+ }
+ }
+ if (iter->n_off == 0) return 0;
+ while (1) {
+ int ret;
+ if (iter->curr_off == 0 || iter->curr_off >= iter->off[iter->i].v) { // then jump to the next chunk
+ if (iter->i == iter->n_off - 1) break; // no more chunks
+ if (iter->i >= 0) assert(iter->curr_off == iter->off[iter->i].v); // otherwise bug
+ if (iter->i < 0 || iter->off[iter->i].v != iter->off[iter->i+1].u) { // not adjacent chunks; then seek
+ bgzf_seek(fp, iter->off[iter->i+1].u, SEEK_SET);
+ iter->curr_off = bgzf_tell(fp);
+ }
+ ++iter->i;
+ }
+ if ((ret = ti_readline(fp, &iter->str)) >= 0) {
+ ti_intv_t intv;
+ iter->curr_off = bgzf_tell(fp);
+ if (iter->str.s[0] == iter->idx->conf.meta_char) continue;
+ get_intv((ti_index_t*)iter->idx, &iter->str, &intv);
+ if (intv.tid != iter->tid || intv.beg >= iter->end) break; // no need to proceed
+ else if (intv.end > iter->beg && iter->end > intv.beg) {
+ if (len) *len = iter->str.l;
+ return iter->str.s;
+ }
+ } else break; // end of file
+ }
+ iter->finished = 1;
+ return 0;
+}
+
+void ti_iter_destroy(ti_iter_t iter)
+{
+ if (iter) {
+ free(iter->str.s); free(iter->off);
+ free(iter);
+ }
+}
+
+int ti_fetch(BGZF *fp, const ti_index_t *idx, int tid, int beg, int end, void *data, ti_fetch_f func)
+{
+ ti_iter_t iter;
+ const char *s;
+ int len;
+ iter = ti_iter_query(idx, tid, beg, end);
+ while ((s = ti_iter_read(fp, iter, &len)) != 0)
+ func(len, s, data);
+ ti_iter_destroy(iter);
+ return 0;
+}
+
+const ti_conf_t *ti_get_conf(ti_index_t *idx) { return idx? &idx->conf : 0; }
+
+/*******************
+ * High-level APIs *
+ *******************/
+
+tabix_t *ti_open(const char *fn, const char *fnidx)
+{
+ tabix_t *t;
+ BGZF *fp;
+ if ((fp = bgzf_open(fn, "r")) == 0) return 0;
+ t = calloc(1, sizeof(tabix_t));
+ t->fn = strdup(fn);
+ if (fnidx) t->fnidx = strdup(fnidx);
+ t->fp = fp;
+ return t;
+}
+
+void ti_close(tabix_t *t)
+{
+ if (t) {
+ bgzf_close(t->fp);
+ if (t->idx) ti_index_destroy(t->idx);
+ free(t->fn); free(t->fnidx);
+ free(t);
+ }
+}
+
+int ti_lazy_index_load(tabix_t *t)
+{
+ if (t->idx == 0) { // load index
+ if (t->fnidx) t->idx = ti_index_load_local(t->fnidx);
+ else t->idx = ti_index_load(t->fn);
+ if (t->idx == 0) return -1; // fail to load index
+ }
+ return 0;
+}
+
+ti_iter_t ti_queryi(tabix_t *t, int tid, int beg, int end)
+{
+ if (tid < 0) return ti_iter_first();
+ if (ti_lazy_index_load(t) != 0) return 0;
+ return ti_iter_query(t->idx, tid, beg, end);
+}
+
+ti_iter_t ti_querys(tabix_t *t, const char *reg)
+{
+ int tid, beg, end;
+ if (reg == 0) return ti_iter_first();
+ if (ti_lazy_index_load(t) != 0) return 0;
+ if (ti_parse_region(t->idx, reg, &tid, &beg, &end) < 0) return 0;
+ return ti_iter_query(t->idx, tid, beg, end);
+}
+
+ti_iter_t ti_query(tabix_t *t, const char *name, int beg, int end)
+{
+ int tid;
+ if (name == 0) return ti_iter_first();
+ // then need to load the index
+ if (ti_lazy_index_load(t) != 0) return 0;
+ if ((tid = ti_get_tid(t->idx, name)) < 0) return 0;
+ return ti_iter_query(t->idx, tid, beg, end);
+}
+
+const char *ti_read(tabix_t *t, ti_iter_t iter, int *len)
+{
+ return ti_iter_read(t->fp, iter, len);
+}
+++ /dev/null
-/* The MIT License
-
- Copyright (c) 2008 Genome Research Ltd (GRL).
-
- Permission is hereby granted, free of charge, to any person obtaining
- a copy of this software and associated documentation files (the
- "Software"), to deal in the Software without restriction, including
- without limitation the rights to use, copy, modify, merge, publish,
- distribute, sublicense, and/or sell copies of the Software, and to
- permit persons to whom the Software is furnished to do so, subject to
- the following conditions:
-
- The above copyright notice and this permission notice shall be
- included in all copies or substantial portions of the Software.
-
- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
- EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
- MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
- NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
- BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
- ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
- CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
- SOFTWARE.
-*/
-
-/* Contact: Heng Li <lh3@sanger.ac.uk> */
-
-/* Probably I will not do socket programming in the next few years and
- therefore I decide to heavily annotate this file, for Linux and
- Windows as well. -lh3 */
-
-#include <time.h>
-#include <stdio.h>
-#include <ctype.h>
-#include <stdlib.h>
-#include <string.h>
-#include <errno.h>
-#include <unistd.h>
-#include <sys/types.h>
-
-#ifdef _WIN32
-#include <winsock.h>
-#else
-#include <netdb.h>
-#include <arpa/inet.h>
-#include <sys/socket.h>
-#endif
-
-#include "knetfile.h"
-
-/* In winsock.h, the type of a socket is SOCKET, which is: "typedef
- * u_int SOCKET". An invalid SOCKET is: "(SOCKET)(~0)", or signed
- * integer -1. In knetfile.c, I use "int" for socket type
- * throughout. This should be improved to avoid confusion.
- *
- * In Linux/Mac, recv() and read() do almost the same thing. You can see
- * in the header file that netread() is simply an alias of read(). In
- * Windows, however, they are different and using recv() is mandatory.
- */
-
-/* This function tests if the file handler is ready for reading (or
- * writing if is_read==0). */
-static int socket_wait(int fd, int is_read)
-{
- fd_set fds, *fdr = 0, *fdw = 0;
- struct timeval tv;
- int ret;
- tv.tv_sec = 5; tv.tv_usec = 0; // 5 seconds time out
- FD_ZERO(&fds);
- FD_SET(fd, &fds);
- if (is_read) fdr = &fds;
- else fdw = &fds;
- ret = select(fd+1, fdr, fdw, 0, &tv);
-#ifndef _WIN32
- if (ret == -1) perror("select");
-#else
- if (ret == 0)
- fprintf(stderr, "select time-out\n");
- else if (ret == SOCKET_ERROR)
- fprintf(stderr, "select: %d\n", WSAGetLastError());
-#endif
- return ret;
-}
-
-#ifndef _WIN32
-/* This function does not work with Windows due to the lack of
- * getaddrinfo() in winsock. It is addapted from an example in "Beej's
- * Guide to Network Programming" (http://beej.us/guide/bgnet/). */
-static int socket_connect(const char *host, const char *port)
-{
-#define __err_connect(func) do { perror(func); freeaddrinfo(res); return -1; } while (0)
-
- int on = 1, fd;
- struct linger lng = { 0, 0 };
- struct addrinfo hints, *res;
- memset(&hints, 0, sizeof(struct addrinfo));
- hints.ai_family = AF_UNSPEC;
- hints.ai_socktype = SOCK_STREAM;
- /* In Unix/Mac, getaddrinfo() is the most convenient way to get
- * server information. */
- if (getaddrinfo(host, port, &hints, &res) != 0) __err_connect("getaddrinfo");
- if ((fd = socket(res->ai_family, res->ai_socktype, res->ai_protocol)) == -1) __err_connect("socket");
- /* The following two setsockopt() are used by ftplib
- * (http://nbpfaus.net/~pfau/ftplib/). I am not sure if they
- * necessary. */
- if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &on, sizeof(on)) == -1) __err_connect("setsockopt");
- if (setsockopt(fd, SOL_SOCKET, SO_LINGER, &lng, sizeof(lng)) == -1) __err_connect("setsockopt");
- if (connect(fd, res->ai_addr, res->ai_addrlen) != 0) __err_connect("connect");
- freeaddrinfo(res);
- return fd;
-}
-#else
-/* MinGW's printf has problem with "%lld" */
-char *int64tostr(char *buf, int64_t x)
-{
- int cnt;
- int i = 0;
- do {
- buf[i++] = '0' + x % 10;
- x /= 10;
- } while (x);
- buf[i] = 0;
- for (cnt = i, i = 0; i < cnt/2; ++i) {
- int c = buf[i]; buf[i] = buf[cnt-i-1]; buf[cnt-i-1] = c;
- }
- return buf;
-}
-
-int64_t strtoint64(const char *buf)
-{
- int64_t x;
- for (x = 0; *buf != '\0'; ++buf)
- x = x * 10 + ((int64_t) *buf - 48);
- return x;
-}
-/* In windows, the first thing is to establish the TCP connection. */
-int knet_win32_init()
-{
- WSADATA wsaData;
- return WSAStartup(MAKEWORD(2, 2), &wsaData);
-}
-void knet_win32_destroy()
-{
- WSACleanup();
-}
-/* A slightly modfied version of the following function also works on
- * Mac (and presummably Linux). However, this function is not stable on
- * my Mac. It sometimes works fine but sometimes does not. Therefore for
- * non-Windows OS, I do not use this one. */
-static SOCKET socket_connect(const char *host, const char *port)
-{
-#define __err_connect(func) \
- do { \
- fprintf(stderr, "%s: %d\n", func, WSAGetLastError()); \
- return -1; \
- } while (0)
-
- int on = 1;
- SOCKET fd;
- struct linger lng = { 0, 0 };
- struct sockaddr_in server;
- struct hostent *hp = 0;
- // open socket
- if ((fd = socket(AF_INET, SOCK_STREAM, IPPROTO_TCP)) == INVALID_SOCKET) __err_connect("socket");
- if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, (char*)&on, sizeof(on)) == -1) __err_connect("setsockopt");
- if (setsockopt(fd, SOL_SOCKET, SO_LINGER, (char*)&lng, sizeof(lng)) == -1) __err_connect("setsockopt");
- // get host info
- if (isalpha(host[0])) hp = gethostbyname(host);
- else {
- struct in_addr addr;
- addr.s_addr = inet_addr(host);
- hp = gethostbyaddr((char*)&addr, 4, AF_INET);
- }
- if (hp == 0) __err_connect("gethost");
- // connect
- server.sin_addr.s_addr = *((unsigned long*)hp->h_addr);
- server.sin_family= AF_INET;
- server.sin_port = htons(atoi(port));
- if (connect(fd, (struct sockaddr*)&server, sizeof(server)) != 0) __err_connect("connect");
- // freehostent(hp); // strangely in MSDN, hp is NOT freed (memory leak?!)
- return fd;
-}
-#endif
-
-static off_t my_netread(int fd, void *buf, off_t len)
-{
- off_t rest = len, curr, l = 0;
- /* recv() and read() may not read the required length of data with
- * one call. They have to be called repeatedly. */
- while (rest) {
- if (socket_wait(fd, 1) <= 0) break; // socket is not ready for reading
- curr = netread(fd, buf + l, rest);
- /* According to the glibc manual, section 13.2, a zero returned
- * value indicates end-of-file (EOF), which should mean that
- * read() will not return zero if EOF has not been met but data
- * are not immediately available. */
- if (curr == 0) break;
- l += curr; rest -= curr;
- }
- return l;
-}
-
-/*************************
- * FTP specific routines *
- *************************/
-
-static int kftp_get_response(knetFile *ftp)
-{
-#ifndef _WIN32
- unsigned char c;
-#else
- char c;
-#endif
- int n = 0;
- char *p;
- if (socket_wait(ftp->ctrl_fd, 1) <= 0) return 0;
- while (netread(ftp->ctrl_fd, &c, 1)) { // FIXME: this is *VERY BAD* for unbuffered I/O
- //fputc(c, stderr);
- if (n >= ftp->max_response) {
- ftp->max_response = ftp->max_response? ftp->max_response<<1 : 256;
- ftp->response = realloc(ftp->response, ftp->max_response);
- }
- ftp->response[n++] = c;
- if (c == '\n') {
- if (n >= 4 && isdigit(ftp->response[0]) && isdigit(ftp->response[1]) && isdigit(ftp->response[2])
- && ftp->response[3] != '-') break;
- n = 0;
- continue;
- }
- }
- if (n < 2) return -1;
- ftp->response[n-2] = 0;
- return strtol(ftp->response, &p, 0);
-}
-
-static int kftp_send_cmd(knetFile *ftp, const char *cmd, int is_get)
-{
- if (socket_wait(ftp->ctrl_fd, 0) <= 0) return -1; // socket is not ready for writing
- netwrite(ftp->ctrl_fd, cmd, strlen(cmd));
- return is_get? kftp_get_response(ftp) : 0;
-}
-
-static int kftp_pasv_prep(knetFile *ftp)
-{
- char *p;
- int v[6];
- kftp_send_cmd(ftp, "PASV\r\n", 1);
- for (p = ftp->response; *p && *p != '('; ++p);
- if (*p != '(') return -1;
- ++p;
- sscanf(p, "%d,%d,%d,%d,%d,%d", &v[0], &v[1], &v[2], &v[3], &v[4], &v[5]);
- memcpy(ftp->pasv_ip, v, 4 * sizeof(int));
- ftp->pasv_port = (v[4]<<8&0xff00) + v[5];
- return 0;
-}
-
-
-static int kftp_pasv_connect(knetFile *ftp)
-{
- char host[80], port[10];
- if (ftp->pasv_port == 0) {
- fprintf(stderr, "[kftp_pasv_connect] kftp_pasv_prep() is not called before hand.\n");
- return -1;
- }
- sprintf(host, "%d.%d.%d.%d", ftp->pasv_ip[0], ftp->pasv_ip[1], ftp->pasv_ip[2], ftp->pasv_ip[3]);
- sprintf(port, "%d", ftp->pasv_port);
- ftp->fd = socket_connect(host, port);
- if (ftp->fd == -1) return -1;
- return 0;
-}
-
-int kftp_connect(knetFile *ftp)
-{
- ftp->ctrl_fd = socket_connect(ftp->host, ftp->port);
- if (ftp->ctrl_fd == -1) return -1;
- kftp_get_response(ftp);
- kftp_send_cmd(ftp, "USER anonymous\r\n", 1);
- kftp_send_cmd(ftp, "PASS kftp@\r\n", 1);
- kftp_send_cmd(ftp, "TYPE I\r\n", 1);
- return 0;
-}
-
-int kftp_reconnect(knetFile *ftp)
-{
- if (ftp->ctrl_fd != -1) {
- netclose(ftp->ctrl_fd);
- ftp->ctrl_fd = -1;
- }
- netclose(ftp->fd);
- ftp->fd = -1;
- return kftp_connect(ftp);
-}
-
-// initialize ->type, ->host, ->retr and ->size
-knetFile *kftp_parse_url(const char *fn, const char *mode)
-{
- knetFile *fp;
- char *p;
- int l;
- if (strstr(fn, "ftp://") != fn) return 0;
- for (p = (char*)fn + 6; *p && *p != '/'; ++p);
- if (*p != '/') return 0;
- l = p - fn - 6;
- fp = calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_FTP;
- fp->fd = -1;
- /* the Linux/Mac version of socket_connect() also recognizes a port
- * like "ftp", but the Windows version does not. */
- fp->port = strdup("21");
- fp->host = calloc(l + 1, 1);
- if (strchr(mode, 'c')) fp->no_reconnect = 1;
- strncpy(fp->host, fn + 6, l);
- fp->retr = calloc(strlen(p) + 8, 1);
- sprintf(fp->retr, "RETR %s\r\n", p);
- fp->size_cmd = calloc(strlen(p) + 8, 1);
- sprintf(fp->size_cmd, "SIZE %s\r\n", p);
- fp->seek_offset = 0;
- return fp;
-}
-// place ->fd at offset off
-int kftp_connect_file(knetFile *fp)
-{
- int ret;
- long long file_size;
- if (fp->fd != -1) {
- netclose(fp->fd);
- if (fp->no_reconnect) kftp_get_response(fp);
- }
- kftp_pasv_prep(fp);
- kftp_send_cmd(fp, fp->size_cmd, 1);
-#ifndef _WIN32
- if ( sscanf(fp->response,"%*d %lld", &file_size) != 1 )
- {
- fprintf(stderr,"[kftp_connect_file] %s\n", fp->response);
- return -1;
- }
-#else
- const char *p = fp->response;
- while (*p != ' ') ++p;
- while (*p < '0' || *p > '9') ++p;
- file_size = strtoint64(p);
-#endif
- fp->file_size = file_size;
- if (fp->offset>=0) {
- char tmp[32];
-#ifndef _WIN32
- sprintf(tmp, "REST %lld\r\n", (long long)fp->offset);
-#else
- strcpy(tmp, "REST ");
- int64tostr(tmp + 5, fp->offset);
- strcat(tmp, "\r\n");
-#endif
- kftp_send_cmd(fp, tmp, 1);
- }
- kftp_send_cmd(fp, fp->retr, 0);
- kftp_pasv_connect(fp);
- ret = kftp_get_response(fp);
- if (ret != 150) {
- fprintf(stderr, "[kftp_connect_file] %s\n", fp->response);
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- fp->is_ready = 1;
- return 0;
-}
-
-
-/**************************
- * HTTP specific routines *
- **************************/
-
-knetFile *khttp_parse_url(const char *fn, const char *mode)
-{
- knetFile *fp;
- char *p, *proxy, *q;
- int l;
- if (strstr(fn, "http://") != fn) return 0;
- // set ->http_host
- for (p = (char*)fn + 7; *p && *p != '/'; ++p);
- l = p - fn - 7;
- fp = calloc(1, sizeof(knetFile));
- fp->http_host = calloc(l + 1, 1);
- strncpy(fp->http_host, fn + 7, l);
- fp->http_host[l] = 0;
- for (q = fp->http_host; *q && *q != ':'; ++q);
- if (*q == ':') *q++ = 0;
- // get http_proxy
- proxy = getenv("http_proxy");
- // set ->host, ->port and ->path
- if (proxy == 0) {
- fp->host = strdup(fp->http_host); // when there is no proxy, server name is identical to http_host name.
- fp->port = strdup(*q? q : "80");
- fp->path = strdup(*p? p : "/");
- } else {
- fp->host = (strstr(proxy, "http://") == proxy)? strdup(proxy + 7) : strdup(proxy);
- for (q = fp->host; *q && *q != ':'; ++q);
- if (*q == ':') *q++ = 0;
- fp->port = strdup(*q? q : "80");
- fp->path = strdup(fn);
- }
- fp->type = KNF_TYPE_HTTP;
- fp->ctrl_fd = fp->fd = -1;
- fp->seek_offset = 0;
- return fp;
-}
-
-int khttp_connect_file(knetFile *fp)
-{
- int ret, l = 0;
- char *buf, *p;
- if (fp->fd != -1) netclose(fp->fd);
- fp->fd = socket_connect(fp->host, fp->port);
- buf = calloc(0x10000, 1); // FIXME: I am lazy... But in principle, 64KB should be large enough.
- l += sprintf(buf + l, "GET %s HTTP/1.0\r\nHost: %s\r\n", fp->path, fp->http_host);
- l += sprintf(buf + l, "Range: bytes=%lld-\r\n", (long long)fp->offset);
- l += sprintf(buf + l, "\r\n");
- netwrite(fp->fd, buf, l);
- l = 0;
- while (netread(fp->fd, buf + l, 1)) { // read HTTP header; FIXME: bad efficiency
- if (buf[l] == '\n' && l >= 3)
- if (strncmp(buf + l - 3, "\r\n\r\n", 4) == 0) break;
- ++l;
- }
- buf[l] = 0;
- if (l < 14) { // prematured header
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- ret = strtol(buf + 8, &p, 0); // HTTP return code
- if (ret == 200 && fp->offset>0) { // 200 (complete result); then skip beginning of the file
- off_t rest = fp->offset;
- while (rest) {
- off_t l = rest < 0x10000? rest : 0x10000;
- rest -= my_netread(fp->fd, buf, l);
- }
- } else if (ret != 206 && ret != 200) {
- free(buf);
- fprintf(stderr, "[khttp_connect_file] fail to open file (HTTP code: %d).\n", ret);
- netclose(fp->fd);
- fp->fd = -1;
- return -1;
- }
- free(buf);
- fp->is_ready = 1;
- return 0;
-}
-
-/********************
- * Generic routines *
- ********************/
-
-knetFile *knet_open(const char *fn, const char *mode)
-{
- knetFile *fp = 0;
- if (mode[0] != 'r') {
- fprintf(stderr, "[kftp_open] only mode \"r\" is supported.\n");
- return 0;
- }
- if (strstr(fn, "ftp://") == fn) {
- fp = kftp_parse_url(fn, mode);
- if (fp == 0) return 0;
- if (kftp_connect(fp) == -1) {
- knet_close(fp);
- return 0;
- }
- kftp_connect_file(fp);
- } else if (strstr(fn, "http://") == fn) {
- fp = khttp_parse_url(fn, mode);
- if (fp == 0) return 0;
- khttp_connect_file(fp);
- } else { // local file
-#ifdef _WIN32
- /* In windows, O_BINARY is necessary. In Linux/Mac, O_BINARY may
- * be undefined on some systems, although it is defined on my
- * Mac and the Linux I have tested on. */
- int fd = open(fn, O_RDONLY | O_BINARY);
-#else
- int fd = open(fn, O_RDONLY);
-#endif
- if (fd == -1) {
- perror("open");
- return 0;
- }
- fp = (knetFile*)calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_LOCAL;
- fp->fd = fd;
- fp->ctrl_fd = -1;
- }
- if (fp && fp->fd == -1) {
- knet_close(fp);
- return 0;
- }
- return fp;
-}
-
-knetFile *knet_dopen(int fd, const char *mode)
-{
- knetFile *fp = (knetFile*)calloc(1, sizeof(knetFile));
- fp->type = KNF_TYPE_LOCAL;
- fp->fd = fd;
- return fp;
-}
-
-off_t knet_read(knetFile *fp, void *buf, off_t len)
-{
- off_t l = 0;
- if (fp->fd == -1) return 0;
- if (fp->type == KNF_TYPE_FTP) {
- if (fp->is_ready == 0) {
- if (!fp->no_reconnect) kftp_reconnect(fp);
- kftp_connect_file(fp);
- }
- } else if (fp->type == KNF_TYPE_HTTP) {
- if (fp->is_ready == 0)
- khttp_connect_file(fp);
- }
- if (fp->type == KNF_TYPE_LOCAL) { // on Windows, the following block is necessary; not on UNIX
- off_t rest = len, curr;
- while (rest) {
- curr = read(fp->fd, buf + l, rest);
- if (curr == 0) break;
- l += curr; rest -= curr;
- }
- } else l = my_netread(fp->fd, buf, len);
- fp->offset += l;
- return l;
-}
-
-off_t knet_seek(knetFile *fp, int64_t off, int whence)
-{
- if (whence == SEEK_SET && off == fp->offset) return 0;
- if (fp->type == KNF_TYPE_LOCAL) {
- /* Be aware that lseek() returns the offset after seeking,
- * while fseek() returns zero on success. */
- off_t offset = lseek(fp->fd, off, whence);
- if (offset == -1) {
- // Be silent, it is OK for knet_seek to fail when the file is streamed
- // fprintf(stderr,"[knet_seek] %s\n", strerror(errno));
- return -1;
- }
- fp->offset = offset;
- return 0;
- }
- else if (fp->type == KNF_TYPE_FTP)
- {
- if (whence==SEEK_CUR)
- fp->offset += off;
- else if (whence==SEEK_SET)
- fp->offset = off;
- else if ( whence==SEEK_END)
- fp->offset = fp->file_size+off;
- fp->is_ready = 0;
- return 0;
- }
- else if (fp->type == KNF_TYPE_HTTP)
- {
- if (whence == SEEK_END) { // FIXME: can we allow SEEK_END in future?
- fprintf(stderr, "[knet_seek] SEEK_END is not supported for HTTP. Offset is unchanged.\n");
- errno = ESPIPE;
- return -1;
- }
- if (whence==SEEK_CUR)
- fp->offset += off;
- else if (whence==SEEK_SET)
- fp->offset = off;
- fp->is_ready = 0;
- return fp->offset;
- }
- errno = EINVAL;
- fprintf(stderr,"[knet_seek] %s\n", strerror(errno));
- return -1;
-}
-
-int knet_close(knetFile *fp)
-{
- if (fp == 0) return 0;
- if (fp->ctrl_fd != -1) netclose(fp->ctrl_fd); // FTP specific
- if (fp->fd != -1) {
- /* On Linux/Mac, netclose() is an alias of close(), but on
- * Windows, it is an alias of closesocket(). */
- if (fp->type == KNF_TYPE_LOCAL) close(fp->fd);
- else netclose(fp->fd);
- }
- free(fp->host); free(fp->port);
- free(fp->response); free(fp->retr); free(fp->size_cmd); // FTP specific
- free(fp->path); free(fp->http_host); // HTTP specific
- free(fp);
- return 0;
-}
-
-#ifdef KNETFILE_MAIN
-int main(void)
-{
- char *buf;
- knetFile *fp;
- int type = 4, l;
-#ifdef _WIN32
- knet_win32_init();
-#endif
- buf = calloc(0x100000, 1);
- if (type == 0) {
- fp = knet_open("knetfile.c", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 1) { // NCBI FTP, large file
- fp = knet_open("ftp://ftp.ncbi.nih.gov/1000genomes/ftp/data/NA12878/alignment/NA12878.chrom6.SLX.SRP000032.2009_06.bam", "r");
- knet_seek(fp, 2500000000ll, SEEK_SET);
- l = knet_read(fp, buf, 255);
- } else if (type == 2) {
- fp = knet_open("ftp://ftp.sanger.ac.uk/pub4/treefam/tmp/index.shtml", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 3) {
- fp = knet_open("http://www.sanger.ac.uk/Users/lh3/index.shtml", "r");
- knet_seek(fp, 1000, SEEK_SET);
- } else if (type == 4) {
- fp = knet_open("http://www.sanger.ac.uk/Users/lh3/ex1.bam", "r");
- knet_read(fp, buf, 10000);
- knet_seek(fp, 20000, SEEK_SET);
- knet_seek(fp, 10000, SEEK_SET);
- l = knet_read(fp, buf+10000, 10000000) + 10000;
- }
- if (type != 4 && type != 1) {
- knet_read(fp, buf, 255);
- buf[255] = 0;
- printf("%s\n", buf);
- } else write(fileno(stdout), buf, l);
- knet_close(fp);
- free(buf);
- return 0;
-}
-#endif
--- /dev/null
+#include "pysam.h"
+
+/* The MIT License
+
+ Copyright (c) 2008 Genome Research Ltd (GRL).
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+/* Contact: Heng Li <lh3@sanger.ac.uk> */
+
+/* Probably I will not do socket programming in the next few years and
+ therefore I decide to heavily annotate this file, for Linux and
+ Windows as well. -lh3 */
+
+#include <time.h>
+#include <stdio.h>
+#include <ctype.h>
+#include <stdlib.h>
+#include <string.h>
+#include <errno.h>
+#include <unistd.h>
+#include <sys/types.h>
+
+#ifdef _WIN32
+#include <winsock.h>
+#else
+#include <netdb.h>
+#include <arpa/inet.h>
+#include <sys/socket.h>
+#endif
+
+#include "knetfile.h"
+
+/* In winsock.h, the type of a socket is SOCKET, which is: "typedef
+ * u_int SOCKET". An invalid SOCKET is: "(SOCKET)(~0)", or signed
+ * integer -1. In knetfile.c, I use "int" for socket type
+ * throughout. This should be improved to avoid confusion.
+ *
+ * In Linux/Mac, recv() and read() do almost the same thing. You can see
+ * in the header file that netread() is simply an alias of read(). In
+ * Windows, however, they are different and using recv() is mandatory.
+ */
+
+/* This function tests if the file handler is ready for reading (or
+ * writing if is_read==0). */
+static int socket_wait(int fd, int is_read)
+{
+ fd_set fds, *fdr = 0, *fdw = 0;
+ struct timeval tv;
+ int ret;
+ tv.tv_sec = 5; tv.tv_usec = 0; // 5 seconds time out
+ FD_ZERO(&fds);
+ FD_SET(fd, &fds);
+ if (is_read) fdr = &fds;
+ else fdw = &fds;
+ ret = select(fd+1, fdr, fdw, 0, &tv);
+#ifndef _WIN32
+ if (ret == -1) perror("select");
+#else
+ if (ret == 0)
+ fprintf(pysamerr, "select time-out\n");
+ else if (ret == SOCKET_ERROR)
+ fprintf(pysamerr, "select: %d\n", WSAGetLastError());
+#endif
+ return ret;
+}
+
+#ifndef _WIN32
+/* This function does not work with Windows due to the lack of
+ * getaddrinfo() in winsock. It is addapted from an example in "Beej's
+ * Guide to Network Programming" (http://beej.us/guide/bgnet/). */
+static int socket_connect(const char *host, const char *port)
+{
+#define __err_connect(func) do { perror(func); freeaddrinfo(res); return -1; } while (0)
+
+ int on = 1, fd;
+ struct linger lng = { 0, 0 };
+ struct addrinfo hints, *res;
+ memset(&hints, 0, sizeof(struct addrinfo));
+ hints.ai_family = AF_UNSPEC;
+ hints.ai_socktype = SOCK_STREAM;
+ /* In Unix/Mac, getaddrinfo() is the most convenient way to get
+ * server information. */
+ if (getaddrinfo(host, port, &hints, &res) != 0) __err_connect("getaddrinfo");
+ if ((fd = socket(res->ai_family, res->ai_socktype, res->ai_protocol)) == -1) __err_connect("socket");
+ /* The following two setsockopt() are used by ftplib
+ * (http://nbpfaus.net/~pfau/ftplib/). I am not sure if they
+ * necessary. */
+ if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, &on, sizeof(on)) == -1) __err_connect("setsockopt");
+ if (setsockopt(fd, SOL_SOCKET, SO_LINGER, &lng, sizeof(lng)) == -1) __err_connect("setsockopt");
+ if (connect(fd, res->ai_addr, res->ai_addrlen) != 0) __err_connect("connect");
+ freeaddrinfo(res);
+ return fd;
+}
+#else
+/* MinGW's printf has problem with "%lld" */
+char *int64tostr(char *buf, int64_t x)
+{
+ int cnt;
+ int i = 0;
+ do {
+ buf[i++] = '0' + x % 10;
+ x /= 10;
+ } while (x);
+ buf[i] = 0;
+ for (cnt = i, i = 0; i < cnt/2; ++i) {
+ int c = buf[i]; buf[i] = buf[cnt-i-1]; buf[cnt-i-1] = c;
+ }
+ return buf;
+}
+
+int64_t strtoint64(const char *buf)
+{
+ int64_t x;
+ for (x = 0; *buf != '\0'; ++buf)
+ x = x * 10 + ((int64_t) *buf - 48);
+ return x;
+}
+/* In windows, the first thing is to establish the TCP connection. */
+int knet_win32_init()
+{
+ WSADATA wsaData;
+ return WSAStartup(MAKEWORD(2, 2), &wsaData);
+}
+void knet_win32_destroy()
+{
+ WSACleanup();
+}
+/* A slightly modfied version of the following function also works on
+ * Mac (and presummably Linux). However, this function is not stable on
+ * my Mac. It sometimes works fine but sometimes does not. Therefore for
+ * non-Windows OS, I do not use this one. */
+static SOCKET socket_connect(const char *host, const char *port)
+{
+#define __err_connect(func) \
+ do { \
+ fprintf(pysamerr, "%s: %d\n", func, WSAGetLastError()); \
+ return -1; \
+ } while (0)
+
+ int on = 1;
+ SOCKET fd;
+ struct linger lng = { 0, 0 };
+ struct sockaddr_in server;
+ struct hostent *hp = 0;
+ // open socket
+ if ((fd = socket(AF_INET, SOCK_STREAM, IPPROTO_TCP)) == INVALID_SOCKET) __err_connect("socket");
+ if (setsockopt(fd, SOL_SOCKET, SO_REUSEADDR, (char*)&on, sizeof(on)) == -1) __err_connect("setsockopt");
+ if (setsockopt(fd, SOL_SOCKET, SO_LINGER, (char*)&lng, sizeof(lng)) == -1) __err_connect("setsockopt");
+ // get host info
+ if (isalpha(host[0])) hp = gethostbyname(host);
+ else {
+ struct in_addr addr;
+ addr.s_addr = inet_addr(host);
+ hp = gethostbyaddr((char*)&addr, 4, AF_INET);
+ }
+ if (hp == 0) __err_connect("gethost");
+ // connect
+ server.sin_addr.s_addr = *((unsigned long*)hp->h_addr);
+ server.sin_family= AF_INET;
+ server.sin_port = htons(atoi(port));
+ if (connect(fd, (struct sockaddr*)&server, sizeof(server)) != 0) __err_connect("connect");
+ // freehostent(hp); // strangely in MSDN, hp is NOT freed (memory leak?!)
+ return fd;
+}
+#endif
+
+static off_t my_netread(int fd, void *buf, off_t len)
+{
+ off_t rest = len, curr, l = 0;
+ /* recv() and read() may not read the required length of data with
+ * one call. They have to be called repeatedly. */
+ while (rest) {
+ if (socket_wait(fd, 1) <= 0) break; // socket is not ready for reading
+ curr = netread(fd, buf + l, rest);
+ /* According to the glibc manual, section 13.2, a zero returned
+ * value indicates end-of-file (EOF), which should mean that
+ * read() will not return zero if EOF has not been met but data
+ * are not immediately available. */
+ if (curr == 0) break;
+ l += curr; rest -= curr;
+ }
+ return l;
+}
+
+/*************************
+ * FTP specific routines *
+ *************************/
+
+static int kftp_get_response(knetFile *ftp)
+{
+#ifndef _WIN32
+ unsigned char c;
+#else
+ char c;
+#endif
+ int n = 0;
+ char *p;
+ if (socket_wait(ftp->ctrl_fd, 1) <= 0) return 0;
+ while (netread(ftp->ctrl_fd, &c, 1)) { // FIXME: this is *VERY BAD* for unbuffered I/O
+ //fputc(c, pysamerr);
+ if (n >= ftp->max_response) {
+ ftp->max_response = ftp->max_response? ftp->max_response<<1 : 256;
+ ftp->response = realloc(ftp->response, ftp->max_response);
+ }
+ ftp->response[n++] = c;
+ if (c == '\n') {
+ if (n >= 4 && isdigit(ftp->response[0]) && isdigit(ftp->response[1]) && isdigit(ftp->response[2])
+ && ftp->response[3] != '-') break;
+ n = 0;
+ continue;
+ }
+ }
+ if (n < 2) return -1;
+ ftp->response[n-2] = 0;
+ return strtol(ftp->response, &p, 0);
+}
+
+static int kftp_send_cmd(knetFile *ftp, const char *cmd, int is_get)
+{
+ if (socket_wait(ftp->ctrl_fd, 0) <= 0) return -1; // socket is not ready for writing
+ netwrite(ftp->ctrl_fd, cmd, strlen(cmd));
+ return is_get? kftp_get_response(ftp) : 0;
+}
+
+static int kftp_pasv_prep(knetFile *ftp)
+{
+ char *p;
+ int v[6];
+ kftp_send_cmd(ftp, "PASV\r\n", 1);
+ for (p = ftp->response; *p && *p != '('; ++p);
+ if (*p != '(') return -1;
+ ++p;
+ sscanf(p, "%d,%d,%d,%d,%d,%d", &v[0], &v[1], &v[2], &v[3], &v[4], &v[5]);
+ memcpy(ftp->pasv_ip, v, 4 * sizeof(int));
+ ftp->pasv_port = (v[4]<<8&0xff00) + v[5];
+ return 0;
+}
+
+
+static int kftp_pasv_connect(knetFile *ftp)
+{
+ char host[80], port[10];
+ if (ftp->pasv_port == 0) {
+ fprintf(pysamerr, "[kftp_pasv_connect] kftp_pasv_prep() is not called before hand.\n");
+ return -1;
+ }
+ sprintf(host, "%d.%d.%d.%d", ftp->pasv_ip[0], ftp->pasv_ip[1], ftp->pasv_ip[2], ftp->pasv_ip[3]);
+ sprintf(port, "%d", ftp->pasv_port);
+ ftp->fd = socket_connect(host, port);
+ if (ftp->fd == -1) return -1;
+ return 0;
+}
+
+int kftp_connect(knetFile *ftp)
+{
+ ftp->ctrl_fd = socket_connect(ftp->host, ftp->port);
+ if (ftp->ctrl_fd == -1) return -1;
+ kftp_get_response(ftp);
+ kftp_send_cmd(ftp, "USER anonymous\r\n", 1);
+ kftp_send_cmd(ftp, "PASS kftp@\r\n", 1);
+ kftp_send_cmd(ftp, "TYPE I\r\n", 1);
+ return 0;
+}
+
+int kftp_reconnect(knetFile *ftp)
+{
+ if (ftp->ctrl_fd != -1) {
+ netclose(ftp->ctrl_fd);
+ ftp->ctrl_fd = -1;
+ }
+ netclose(ftp->fd);
+ ftp->fd = -1;
+ return kftp_connect(ftp);
+}
+
+// initialize ->type, ->host, ->retr and ->size
+knetFile *kftp_parse_url(const char *fn, const char *mode)
+{
+ knetFile *fp;
+ char *p;
+ int l;
+ if (strstr(fn, "ftp://") != fn) return 0;
+ for (p = (char*)fn + 6; *p && *p != '/'; ++p);
+ if (*p != '/') return 0;
+ l = p - fn - 6;
+ fp = calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_FTP;
+ fp->fd = -1;
+ /* the Linux/Mac version of socket_connect() also recognizes a port
+ * like "ftp", but the Windows version does not. */
+ fp->port = strdup("21");
+ fp->host = calloc(l + 1, 1);
+ if (strchr(mode, 'c')) fp->no_reconnect = 1;
+ strncpy(fp->host, fn + 6, l);
+ fp->retr = calloc(strlen(p) + 8, 1);
+ sprintf(fp->retr, "RETR %s\r\n", p);
+ fp->size_cmd = calloc(strlen(p) + 8, 1);
+ sprintf(fp->size_cmd, "SIZE %s\r\n", p);
+ fp->seek_offset = 0;
+ return fp;
+}
+// place ->fd at offset off
+int kftp_connect_file(knetFile *fp)
+{
+ int ret;
+ long long file_size;
+ if (fp->fd != -1) {
+ netclose(fp->fd);
+ if (fp->no_reconnect) kftp_get_response(fp);
+ }
+ kftp_pasv_prep(fp);
+ kftp_send_cmd(fp, fp->size_cmd, 1);
+#ifndef _WIN32
+ if ( sscanf(fp->response,"%*d %lld", &file_size) != 1 )
+ {
+ fprintf(pysamerr,"[kftp_connect_file] %s\n", fp->response);
+ return -1;
+ }
+#else
+ const char *p = fp->response;
+ while (*p != ' ') ++p;
+ while (*p < '0' || *p > '9') ++p;
+ file_size = strtoint64(p);
+#endif
+ fp->file_size = file_size;
+ if (fp->offset>=0) {
+ char tmp[32];
+#ifndef _WIN32
+ sprintf(tmp, "REST %lld\r\n", (long long)fp->offset);
+#else
+ strcpy(tmp, "REST ");
+ int64tostr(tmp + 5, fp->offset);
+ strcat(tmp, "\r\n");
+#endif
+ kftp_send_cmd(fp, tmp, 1);
+ }
+ kftp_send_cmd(fp, fp->retr, 0);
+ kftp_pasv_connect(fp);
+ ret = kftp_get_response(fp);
+ if (ret != 150) {
+ fprintf(pysamerr, "[kftp_connect_file] %s\n", fp->response);
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ fp->is_ready = 1;
+ return 0;
+}
+
+
+/**************************
+ * HTTP specific routines *
+ **************************/
+
+knetFile *khttp_parse_url(const char *fn, const char *mode)
+{
+ knetFile *fp;
+ char *p, *proxy, *q;
+ int l;
+ if (strstr(fn, "http://") != fn) return 0;
+ // set ->http_host
+ for (p = (char*)fn + 7; *p && *p != '/'; ++p);
+ l = p - fn - 7;
+ fp = calloc(1, sizeof(knetFile));
+ fp->http_host = calloc(l + 1, 1);
+ strncpy(fp->http_host, fn + 7, l);
+ fp->http_host[l] = 0;
+ for (q = fp->http_host; *q && *q != ':'; ++q);
+ if (*q == ':') *q++ = 0;
+ // get http_proxy
+ proxy = getenv("http_proxy");
+ // set ->host, ->port and ->path
+ if (proxy == 0) {
+ fp->host = strdup(fp->http_host); // when there is no proxy, server name is identical to http_host name.
+ fp->port = strdup(*q? q : "80");
+ fp->path = strdup(*p? p : "/");
+ } else {
+ fp->host = (strstr(proxy, "http://") == proxy)? strdup(proxy + 7) : strdup(proxy);
+ for (q = fp->host; *q && *q != ':'; ++q);
+ if (*q == ':') *q++ = 0;
+ fp->port = strdup(*q? q : "80");
+ fp->path = strdup(fn);
+ }
+ fp->type = KNF_TYPE_HTTP;
+ fp->ctrl_fd = fp->fd = -1;
+ fp->seek_offset = 0;
+ return fp;
+}
+
+int khttp_connect_file(knetFile *fp)
+{
+ int ret, l = 0;
+ char *buf, *p;
+ if (fp->fd != -1) netclose(fp->fd);
+ fp->fd = socket_connect(fp->host, fp->port);
+ buf = calloc(0x10000, 1); // FIXME: I am lazy... But in principle, 64KB should be large enough.
+ l += sprintf(buf + l, "GET %s HTTP/1.0\r\nHost: %s\r\n", fp->path, fp->http_host);
+ l += sprintf(buf + l, "Range: bytes=%lld-\r\n", (long long)fp->offset);
+ l += sprintf(buf + l, "\r\n");
+ netwrite(fp->fd, buf, l);
+ l = 0;
+ while (netread(fp->fd, buf + l, 1)) { // read HTTP header; FIXME: bad efficiency
+ if (buf[l] == '\n' && l >= 3)
+ if (strncmp(buf + l - 3, "\r\n\r\n", 4) == 0) break;
+ ++l;
+ }
+ buf[l] = 0;
+ if (l < 14) { // prematured header
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ ret = strtol(buf + 8, &p, 0); // HTTP return code
+ if (ret == 200 && fp->offset>0) { // 200 (complete result); then skip beginning of the file
+ off_t rest = fp->offset;
+ while (rest) {
+ off_t l = rest < 0x10000? rest : 0x10000;
+ rest -= my_netread(fp->fd, buf, l);
+ }
+ } else if (ret != 206 && ret != 200) {
+ free(buf);
+ fprintf(pysamerr, "[khttp_connect_file] fail to open file (HTTP code: %d).\n", ret);
+ netclose(fp->fd);
+ fp->fd = -1;
+ return -1;
+ }
+ free(buf);
+ fp->is_ready = 1;
+ return 0;
+}
+
+/********************
+ * Generic routines *
+ ********************/
+
+knetFile *knet_open(const char *fn, const char *mode)
+{
+ knetFile *fp = 0;
+ if (mode[0] != 'r') {
+ fprintf(pysamerr, "[kftp_open] only mode \"r\" is supported.\n");
+ return 0;
+ }
+ if (strstr(fn, "ftp://") == fn) {
+ fp = kftp_parse_url(fn, mode);
+ if (fp == 0) return 0;
+ if (kftp_connect(fp) == -1) {
+ knet_close(fp);
+ return 0;
+ }
+ kftp_connect_file(fp);
+ } else if (strstr(fn, "http://") == fn) {
+ fp = khttp_parse_url(fn, mode);
+ if (fp == 0) return 0;
+ khttp_connect_file(fp);
+ } else { // local file
+#ifdef _WIN32
+ /* In windows, O_BINARY is necessary. In Linux/Mac, O_BINARY may
+ * be undefined on some systems, although it is defined on my
+ * Mac and the Linux I have tested on. */
+ int fd = open(fn, O_RDONLY | O_BINARY);
+#else
+ int fd = open(fn, O_RDONLY);
+#endif
+ if (fd == -1) {
+ perror("open");
+ return 0;
+ }
+ fp = (knetFile*)calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_LOCAL;
+ fp->fd = fd;
+ fp->ctrl_fd = -1;
+ }
+ if (fp && fp->fd == -1) {
+ knet_close(fp);
+ return 0;
+ }
+ return fp;
+}
+
+knetFile *knet_dopen(int fd, const char *mode)
+{
+ knetFile *fp = (knetFile*)calloc(1, sizeof(knetFile));
+ fp->type = KNF_TYPE_LOCAL;
+ fp->fd = fd;
+ return fp;
+}
+
+off_t knet_read(knetFile *fp, void *buf, off_t len)
+{
+ off_t l = 0;
+ if (fp->fd == -1) return 0;
+ if (fp->type == KNF_TYPE_FTP) {
+ if (fp->is_ready == 0) {
+ if (!fp->no_reconnect) kftp_reconnect(fp);
+ kftp_connect_file(fp);
+ }
+ } else if (fp->type == KNF_TYPE_HTTP) {
+ if (fp->is_ready == 0)
+ khttp_connect_file(fp);
+ }
+ if (fp->type == KNF_TYPE_LOCAL) { // on Windows, the following block is necessary; not on UNIX
+ off_t rest = len, curr;
+ while (rest) {
+ curr = read(fp->fd, buf + l, rest);
+ if (curr == 0) break;
+ l += curr; rest -= curr;
+ }
+ } else l = my_netread(fp->fd, buf, len);
+ fp->offset += l;
+ return l;
+}
+
+off_t knet_seek(knetFile *fp, int64_t off, int whence)
+{
+ if (whence == SEEK_SET && off == fp->offset) return 0;
+ if (fp->type == KNF_TYPE_LOCAL) {
+ /* Be aware that lseek() returns the offset after seeking,
+ * while fseek() returns zero on success. */
+ off_t offset = lseek(fp->fd, off, whence);
+ if (offset == -1) {
+ // Be silent, it is OK for knet_seek to fail when the file is streamed
+ // fprintf(pysamerr,"[knet_seek] %s\n", strerror(errno));
+ return -1;
+ }
+ fp->offset = offset;
+ return 0;
+ }
+ else if (fp->type == KNF_TYPE_FTP)
+ {
+ if (whence==SEEK_CUR)
+ fp->offset += off;
+ else if (whence==SEEK_SET)
+ fp->offset = off;
+ else if ( whence==SEEK_END)
+ fp->offset = fp->file_size+off;
+ fp->is_ready = 0;
+ return 0;
+ }
+ else if (fp->type == KNF_TYPE_HTTP)
+ {
+ if (whence == SEEK_END) { // FIXME: can we allow SEEK_END in future?
+ fprintf(pysamerr, "[knet_seek] SEEK_END is not supported for HTTP. Offset is unchanged.\n");
+ errno = ESPIPE;
+ return -1;
+ }
+ if (whence==SEEK_CUR)
+ fp->offset += off;
+ else if (whence==SEEK_SET)
+ fp->offset = off;
+ fp->is_ready = 0;
+ return fp->offset;
+ }
+ errno = EINVAL;
+ fprintf(pysamerr,"[knet_seek] %s\n", strerror(errno));
+ return -1;
+}
+
+int knet_close(knetFile *fp)
+{
+ if (fp == 0) return 0;
+ if (fp->ctrl_fd != -1) netclose(fp->ctrl_fd); // FTP specific
+ if (fp->fd != -1) {
+ /* On Linux/Mac, netclose() is an alias of close(), but on
+ * Windows, it is an alias of closesocket(). */
+ if (fp->type == KNF_TYPE_LOCAL) close(fp->fd);
+ else netclose(fp->fd);
+ }
+ free(fp->host); free(fp->port);
+ free(fp->response); free(fp->retr); free(fp->size_cmd); // FTP specific
+ free(fp->path); free(fp->http_host); // HTTP specific
+ free(fp);
+ return 0;
+}
+
+#ifdef KNETFILE_MAIN
+int main(void)
+{
+ char *buf;
+ knetFile *fp;
+ int type = 4, l;
+#ifdef _WIN32
+ knet_win32_init();
+#endif
+ buf = calloc(0x100000, 1);
+ if (type == 0) {
+ fp = knet_open("knetfile.c", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 1) { // NCBI FTP, large file
+ fp = knet_open("ftp://ftp.ncbi.nih.gov/1000genomes/ftp/data/NA12878/alignment/NA12878.chrom6.SLX.SRP000032.2009_06.bam", "r");
+ knet_seek(fp, 2500000000ll, SEEK_SET);
+ l = knet_read(fp, buf, 255);
+ } else if (type == 2) {
+ fp = knet_open("ftp://ftp.sanger.ac.uk/pub4/treefam/tmp/index.shtml", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 3) {
+ fp = knet_open("http://www.sanger.ac.uk/Users/lh3/index.shtml", "r");
+ knet_seek(fp, 1000, SEEK_SET);
+ } else if (type == 4) {
+ fp = knet_open("http://www.sanger.ac.uk/Users/lh3/ex1.bam", "r");
+ knet_read(fp, buf, 10000);
+ knet_seek(fp, 20000, SEEK_SET);
+ knet_seek(fp, 10000, SEEK_SET);
+ l = knet_read(fp, buf+10000, 10000000) + 10000;
+ }
+ if (type != 4 && type != 1) {
+ knet_read(fp, buf, 255);
+ buf[255] = 0;
+ printf("%s\n", buf);
+ } else write(fileno(stdout), buf, l);
+ knet_close(fp);
+ free(buf);
+ return 0;
+}
+#endif
--- /dev/null
+/* The MIT License
+
+ Copyright (c) 2008 Genome Research Ltd (GRL).
+
+ Permission is hereby granted, free of charge, to any person obtaining
+ a copy of this software and associated documentation files (the
+ "Software"), to deal in the Software without restriction, including
+ without limitation the rights to use, copy, modify, merge, publish,
+ distribute, sublicense, and/or sell copies of the Software, and to
+ permit persons to whom the Software is furnished to do so, subject to
+ the following conditions:
+
+ The above copyright notice and this permission notice shall be
+ included in all copies or substantial portions of the Software.
+
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
+ EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
+ MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
+ NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS
+ BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN
+ ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN
+ CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+ SOFTWARE.
+*/
+
+/* Contact: Heng Li <lh3@sanger.ac.uk> */
+
+/*
+ 2009-07-16 (lh3): in kstream_t, change "char*" to "unsigned char*"
+ */
+
+/* Last Modified: 12APR2009 */
+
+#ifndef AC_KSEQ_H
+#define AC_KSEQ_H
+
+#include <ctype.h>
+#include <string.h>
+#include <stdlib.h>
+
+#define KS_SEP_SPACE 0 // isspace(): \t, \n, \v, \f, \r
+#define KS_SEP_TAB 1 // isspace() && !' '
+#define KS_SEP_MAX 1
+
+#define __KS_TYPE(type_t) \
+ typedef struct __kstream_t { \
+ unsigned char *buf; \
+ int begin, end, is_eof; \
+ type_t f; \
+ } kstream_t;
+
+#define ks_eof(ks) ((ks)->is_eof && (ks)->begin >= (ks)->end)
+#define ks_rewind(ks) ((ks)->is_eof = (ks)->begin = (ks)->end = 0)
+
+#define __KS_BASIC(type_t, __bufsize) \
+ static inline kstream_t *ks_init(type_t f) \
+ { \
+ kstream_t *ks = (kstream_t*)calloc(1, sizeof(kstream_t)); \
+ ks->f = f; \
+ ks->buf = malloc(__bufsize); \
+ return ks; \
+ } \
+ static inline void ks_destroy(kstream_t *ks) \
+ { \
+ if (ks) { \
+ free(ks->buf); \
+ free(ks); \
+ } \
+ }
+
+#define __KS_GETC(__read, __bufsize) \
+ static inline int ks_getc(kstream_t *ks) \
+ { \
+ if (ks->is_eof && ks->begin >= ks->end) return -1; \
+ if (ks->begin >= ks->end) { \
+ ks->begin = 0; \
+ ks->end = __read(ks->f, ks->buf, __bufsize); \
+ if (ks->end < __bufsize) ks->is_eof = 1; \
+ if (ks->end == 0) return -1; \
+ } \
+ return (int)ks->buf[ks->begin++]; \
+ }
+
+#ifndef KSTRING_T
+#define KSTRING_T kstring_t
+typedef struct __kstring_t {
+ size_t l, m;
+ char *s;
+} kstring_t;
+#endif
+
+#ifndef kroundup32
+#define kroundup32(x) (--(x), (x)|=(x)>>1, (x)|=(x)>>2, (x)|=(x)>>4, (x)|=(x)>>8, (x)|=(x)>>16, ++(x))
+#endif
+
+#define __KS_GETUNTIL(__read, __bufsize) \
+ static int ks_getuntil(kstream_t *ks, int delimiter, kstring_t *str, int *dret) \
+ { \
+ if (dret) *dret = 0; \
+ str->l = 0; \
+ if (ks->begin >= ks->end && ks->is_eof) return -1; \
+ for (;;) { \
+ int i; \
+ if (ks->begin >= ks->end) { \
+ if (!ks->is_eof) { \
+ ks->begin = 0; \
+ ks->end = __read(ks->f, ks->buf, __bufsize); \
+ if (ks->end < __bufsize) ks->is_eof = 1; \
+ if (ks->end == 0) break; \
+ } else break; \
+ } \
+ if (delimiter > KS_SEP_MAX) { \
+ for (i = ks->begin; i < ks->end; ++i) \
+ if (ks->buf[i] == delimiter) break; \
+ } else if (delimiter == KS_SEP_SPACE) { \
+ for (i = ks->begin; i < ks->end; ++i) \
+ if (isspace(ks->buf[i])) break; \
+ } else if (delimiter == KS_SEP_TAB) { \
+ for (i = ks->begin; i < ks->end; ++i) \
+ if (isspace(ks->buf[i]) && ks->buf[i] != ' ') break; \
+ } else i = 0; /* never come to here! */ \
+ if (str->m - str->l < i - ks->begin + 1) { \
+ str->m = str->l + (i - ks->begin) + 1; \
+ kroundup32(str->m); \
+ str->s = (char*)realloc(str->s, str->m); \
+ } \
+ memcpy(str->s + str->l, ks->buf + ks->begin, i - ks->begin); \
+ str->l = str->l + (i - ks->begin); \
+ ks->begin = i + 1; \
+ if (i < ks->end) { \
+ if (dret) *dret = ks->buf[i]; \
+ break; \
+ } \
+ } \
+ if (str->l == 0) { \
+ str->m = 1; \
+ str->s = (char*)calloc(1, 1); \
+ } \
+ str->s[str->l] = '\0'; \
+ return str->l; \
+ }
+
+#define KSTREAM_INIT(type_t, __read, __bufsize) \
+ __KS_TYPE(type_t) \
+ __KS_BASIC(type_t, __bufsize) \
+ __KS_GETC(__read, __bufsize) \
+ __KS_GETUNTIL(__read, __bufsize)
+
+#define __KSEQ_BASIC(type_t) \
+ static inline kseq_t *kseq_init(type_t fd) \
+ { \
+ kseq_t *s = (kseq_t*)calloc(1, sizeof(kseq_t)); \
+ s->f = ks_init(fd); \
+ return s; \
+ } \
+ static inline void kseq_rewind(kseq_t *ks) \
+ { \
+ ks->last_char = 0; \
+ ks->f->is_eof = ks->f->begin = ks->f->end = 0; \
+ } \
+ static inline void kseq_destroy(kseq_t *ks) \
+ { \
+ if (!ks) return; \
+ free(ks->name.s); free(ks->comment.s); free(ks->seq.s); free(ks->qual.s); \
+ ks_destroy(ks->f); \
+ free(ks); \
+ }
+
+/* Return value:
+ >=0 length of the sequence (normal)
+ -1 end-of-file
+ -2 truncated quality string
+ */
+#define __KSEQ_READ \
+ static int kseq_read(kseq_t *seq) \
+ { \
+ int c; \
+ kstream_t *ks = seq->f; \
+ if (seq->last_char == 0) { /* then jump to the next header line */ \
+ while ((c = ks_getc(ks)) != -1 && c != '>' && c != '@'); \
+ if (c == -1) return -1; /* end of file */ \
+ seq->last_char = c; \
+ } /* the first header char has been read */ \
+ seq->comment.l = seq->seq.l = seq->qual.l = 0; \
+ if (ks_getuntil(ks, 0, &seq->name, &c) < 0) return -1; \
+ if (c != '\n') ks_getuntil(ks, '\n', &seq->comment, 0); \
+ while ((c = ks_getc(ks)) != -1 && c != '>' && c != '+' && c != '@') { \
+ if (isgraph(c)) { /* printable non-space character */ \
+ if (seq->seq.l + 1 >= seq->seq.m) { /* double the memory */ \
+ seq->seq.m = seq->seq.l + 2; \
+ kroundup32(seq->seq.m); /* rounded to next closest 2^k */ \
+ seq->seq.s = (char*)realloc(seq->seq.s, seq->seq.m); \
+ } \
+ seq->seq.s[seq->seq.l++] = (char)c; \
+ } \
+ } \
+ if (c == '>' || c == '@') seq->last_char = c; /* the first header char has been read */ \
+ seq->seq.s[seq->seq.l] = 0; /* null terminated string */ \
+ if (c != '+') return seq->seq.l; /* FASTA */ \
+ if (seq->qual.m < seq->seq.m) { /* allocate enough memory */ \
+ seq->qual.m = seq->seq.m; \
+ seq->qual.s = (char*)realloc(seq->qual.s, seq->qual.m); \
+ } \
+ while ((c = ks_getc(ks)) != -1 && c != '\n'); /* skip the rest of '+' line */ \
+ if (c == -1) return -2; /* we should not stop here */ \
+ while ((c = ks_getc(ks)) != -1 && seq->qual.l < seq->seq.l) \
+ if (c >= 33 && c <= 127) seq->qual.s[seq->qual.l++] = (unsigned char)c; \
+ seq->qual.s[seq->qual.l] = 0; /* null terminated string */ \
+ seq->last_char = 0; /* we have not come to the next header line */ \
+ if (seq->seq.l != seq->qual.l) return -2; /* qual string is shorter than seq string */ \
+ return seq->seq.l; \
+ }
+
+#define __KSEQ_TYPE(type_t) \
+ typedef struct { \
+ kstring_t name, comment, seq, qual; \
+ int last_char; \
+ kstream_t *f; \
+ } kseq_t;
+
+#define KSEQ_INIT(type_t, __read) \
+ KSTREAM_INIT(type_t, __read, 4096) \
+ __KSEQ_TYPE(type_t) \
+ __KSEQ_BASIC(type_t) \
+ __KSEQ_READ
+
+#endif
+++ /dev/null
-#include <stdarg.h>
-#include <stdio.h>
-#include <ctype.h>
-#include <string.h>
-#include <stdint.h>
-#include "kstring.h"
-
-int ksprintf(kstring_t *s, const char *fmt, ...)
-{
- va_list ap;
- int l;
- va_start(ap, fmt);
- l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap); // This line does not work with glibc 2.0. See `man snprintf'.
- va_end(ap);
- if (l + 1 > s->m - s->l) {
- s->m = s->l + l + 2;
- kroundup32(s->m);
- s->s = (char*)realloc(s->s, s->m);
- va_start(ap, fmt);
- l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap);
- }
- va_end(ap);
- s->l += l;
- return l;
-}
-
-// s MUST BE a null terminated string; l = strlen(s)
-int ksplit_core(char *s, int delimiter, int *_max, int **_offsets)
-{
- int i, n, max, last_char, last_start, *offsets, l;
- n = 0; max = *_max; offsets = *_offsets;
- l = strlen(s);
-
-#define __ksplit_aux do { \
- if (_offsets) { \
- s[i] = 0; \
- if (n == max) { \
- max = max? max<<1 : 2; \
- offsets = (int*)realloc(offsets, sizeof(int) * max); \
- } \
- offsets[n++] = last_start; \
- } else ++n; \
- } while (0)
-
- for (i = 0, last_char = last_start = 0; i <= l; ++i) {
- if (delimiter == 0) {
- if (isspace(s[i]) || s[i] == 0) {
- if (isgraph(last_char)) __ksplit_aux; // the end of a field
- } else {
- if (isspace(last_char) || last_char == 0) last_start = i;
- }
- } else {
- if (s[i] == delimiter || s[i] == 0) {
- if (last_char != 0 && last_char != delimiter) __ksplit_aux; // the end of a field
- } else {
- if (last_char == delimiter || last_char == 0) last_start = i;
- }
- }
- last_char = s[i];
- }
- *_max = max; *_offsets = offsets;
- return n;
-}
-
-/**********************
- * Boyer-Moore search *
- **********************/
-
-// reference: http://www-igm.univ-mlv.fr/~lecroq/string/node14.html
-int *ksBM_prep(const uint8_t *pat, int m)
-{
- int i, *suff, *prep, *bmGs, *bmBc;
- prep = calloc(m + 256, 1);
- bmGs = prep; bmBc = prep + m;
- { // preBmBc()
- for (i = 0; i < 256; ++i) bmBc[i] = m;
- for (i = 0; i < m - 1; ++i) bmBc[pat[i]] = m - i - 1;
- }
- suff = calloc(m, sizeof(int));
- { // suffixes()
- int f = 0, g;
- suff[m - 1] = m;
- g = m - 1;
- for (i = m - 2; i >= 0; --i) {
- if (i > g && suff[i + m - 1 - f] < i - g)
- suff[i] = suff[i + m - 1 - f];
- else {
- if (i < g) g = i;
- f = i;
- while (g >= 0 && pat[g] == pat[g + m - 1 - f]) --g;
- suff[i] = f - g;
- }
- }
- }
- { // preBmGs()
- int j = 0;
- for (i = 0; i < m; ++i) bmGs[i] = m;
- for (i = m - 1; i >= 0; --i)
- if (suff[i] == i + 1)
- for (; j < m - 1 - i; ++j)
- if (bmGs[j] == m)
- bmGs[j] = m - 1 - i;
- for (i = 0; i <= m - 2; ++i)
- bmGs[m - 1 - suff[i]] = m - 1 - i;
- }
- free(suff);
- return prep;
-}
-
-int *ksBM_search(const uint8_t *str, int n, const uint8_t *pat, int m, int *_prep, int *n_matches)
-{
- int i, j, *prep, *bmGs, *bmBc;
- int *matches = 0, mm = 0, nm = 0;
- prep = _prep? _prep : ksBM_prep(pat, m);
- bmGs = prep; bmBc = prep + m;
- j = 0;
- while (j <= n - m) {
- for (i = m - 1; i >= 0 && pat[i] == str[i+j]; --i);
- if (i < 0) {
- if (nm == mm) {
- mm = mm? mm<<1 : 1;
- matches = realloc(matches, mm * sizeof(int));
- }
- matches[nm++] = j;
- j += bmGs[0];
- } else {
- int max = bmBc[str[i+j]] - m + 1 + i;
- if (max < bmGs[i]) max = bmGs[i];
- j += max;
- }
- }
- *n_matches = nm;
- if (_prep == 0) free(prep);
- return matches;
-}
-
-#ifdef KSTRING_MAIN
-#include <stdio.h>
-int main()
-{
- kstring_t *s;
- int *fields, n, i;
- s = (kstring_t*)calloc(1, sizeof(kstring_t));
- // test ksprintf()
- ksprintf(s, " abcdefg: %d ", 100);
- printf("'%s'\n", s->s);
- // test ksplit()
- fields = ksplit(s, 0, &n);
- for (i = 0; i < n; ++i)
- printf("field[%d] = '%s'\n", i, s->s + fields[i]);
- free(s);
-
- {
- static char *str = "abcdefgcdg";
- static char *pat = "cd";
- int n, *matches;
- matches = ksBM_search(str, strlen(str), pat, strlen(pat), 0, &n);
- printf("%d: \n", n);
- for (i = 0; i < n; ++i)
- printf("- %d\n", matches[i]);
- free(matches);
- }
- return 0;
-}
-#endif
--- /dev/null
+#include "pysam.h"
+
+#include <stdarg.h>
+#include <stdio.h>
+#include <ctype.h>
+#include <string.h>
+#include <stdint.h>
+#include "kstring.h"
+
+int ksprintf(kstring_t *s, const char *fmt, ...)
+{
+ va_list ap;
+ int l;
+ va_start(ap, fmt);
+ l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap); // This line does not work with glibc 2.0. See `man snprintf'.
+ va_end(ap);
+ if (l + 1 > s->m - s->l) {
+ s->m = s->l + l + 2;
+ kroundup32(s->m);
+ s->s = (char*)realloc(s->s, s->m);
+ va_start(ap, fmt);
+ l = vsnprintf(s->s + s->l, s->m - s->l, fmt, ap);
+ }
+ va_end(ap);
+ s->l += l;
+ return l;
+}
+
+// s MUST BE a null terminated string; l = strlen(s)
+int ksplit_core(char *s, int delimiter, int *_max, int **_offsets)
+{
+ int i, n, max, last_char, last_start, *offsets, l;
+ n = 0; max = *_max; offsets = *_offsets;
+ l = strlen(s);
+
+#define __ksplit_aux do { \
+ if (_offsets) { \
+ s[i] = 0; \
+ if (n == max) { \
+ max = max? max<<1 : 2; \
+ offsets = (int*)realloc(offsets, sizeof(int) * max); \
+ } \
+ offsets[n++] = last_start; \
+ } else ++n; \
+ } while (0)
+
+ for (i = 0, last_char = last_start = 0; i <= l; ++i) {
+ if (delimiter == 0) {
+ if (isspace(s[i]) || s[i] == 0) {
+ if (isgraph(last_char)) __ksplit_aux; // the end of a field
+ } else {
+ if (isspace(last_char) || last_char == 0) last_start = i;
+ }
+ } else {
+ if (s[i] == delimiter || s[i] == 0) {
+ if (last_char != 0 && last_char != delimiter) __ksplit_aux; // the end of a field
+ } else {
+ if (last_char == delimiter || last_char == 0) last_start = i;
+ }
+ }
+ last_char = s[i];
+ }
+ *_max = max; *_offsets = offsets;
+ return n;
+}
+
+/**********************
+ * Boyer-Moore search *
+ **********************/
+
+// reference: http://www-igm.univ-mlv.fr/~lecroq/string/node14.html
+int *ksBM_prep(const uint8_t *pat, int m)
+{
+ int i, *suff, *prep, *bmGs, *bmBc;
+ prep = calloc(m + 256, 1);
+ bmGs = prep; bmBc = prep + m;
+ { // preBmBc()
+ for (i = 0; i < 256; ++i) bmBc[i] = m;
+ for (i = 0; i < m - 1; ++i) bmBc[pat[i]] = m - i - 1;
+ }
+ suff = calloc(m, sizeof(int));
+ { // suffixes()
+ int f = 0, g;
+ suff[m - 1] = m;
+ g = m - 1;
+ for (i = m - 2; i >= 0; --i) {
+ if (i > g && suff[i + m - 1 - f] < i - g)
+ suff[i] = suff[i + m - 1 - f];
+ else {
+ if (i < g) g = i;
+ f = i;
+ while (g >= 0 && pat[g] == pat[g + m - 1 - f]) --g;
+ suff[i] = f - g;
+ }
+ }
+ }
+ { // preBmGs()
+ int j = 0;
+ for (i = 0; i < m; ++i) bmGs[i] = m;
+ for (i = m - 1; i >= 0; --i)
+ if (suff[i] == i + 1)
+ for (; j < m - 1 - i; ++j)
+ if (bmGs[j] == m)
+ bmGs[j] = m - 1 - i;
+ for (i = 0; i <= m - 2; ++i)
+ bmGs[m - 1 - suff[i]] = m - 1 - i;
+ }
+ free(suff);
+ return prep;
+}
+
+int *ksBM_search(const uint8_t *str, int n, const uint8_t *pat, int m, int *_prep, int *n_matches)
+{
+ int i, j, *prep, *bmGs, *bmBc;
+ int *matches = 0, mm = 0, nm = 0;
+ prep = _prep? _prep : ksBM_prep(pat, m);
+ bmGs = prep; bmBc = prep + m;
+ j = 0;
+ while (j <= n - m) {
+ for (i = m - 1; i >= 0 && pat[i] == str[i+j]; --i);
+ if (i < 0) {
+ if (nm == mm) {
+ mm = mm? mm<<1 : 1;
+ matches = realloc(matches, mm * sizeof(int));
+ }
+ matches[nm++] = j;
+ j += bmGs[0];
+ } else {
+ int max = bmBc[str[i+j]] - m + 1 + i;
+ if (max < bmGs[i]) max = bmGs[i];
+ j += max;
+ }
+ }
+ *n_matches = nm;
+ if (_prep == 0) free(prep);
+ return matches;
+}
+
+#ifdef KSTRING_MAIN
+#include <stdio.h>
+int main()
+{
+ kstring_t *s;
+ int *fields, n, i;
+ s = (kstring_t*)calloc(1, sizeof(kstring_t));
+ // test ksprintf()
+ ksprintf(s, " abcdefg: %d ", 100);
+ printf("'%s'\n", s->s);
+ // test ksplit()
+ fields = ksplit(s, 0, &n);
+ for (i = 0; i < n; ++i)
+ printf("field[%d] = '%s'\n", i, s->s + fields[i]);
+ free(s);
+
+ {
+ static char *str = "abcdefgcdg";
+ static char *pat = "cd";
+ int n, *matches;
+ matches = ksBM_search(str, strlen(str), pat, strlen(pat), 0, &n);
+ printf("%d: \n", n);
+ for (i = 0; i < n; ++i)
+ printf("- %d\n", matches[i]);
+ free(matches);
+ }
+ return 0;
+}
+#endif
--- /dev/null
+// Windows-specific code, include with:\r
+// #ifdef _MSC_VER\r
+// #include <msvc_compat.h>\r
+// #endif\r
+\r
+//#define _CRT_SECURE_NO_WARNINGS\r
+#ifndef MSVC_COMPAT_H\r
+#define MSVC_COMPAT_H\r
+\r
+#define inline __inline\r
+#define __func__ __FUNCTION__\r
+\r
+#include <float.h>\r
+#define isnan _isnan\r
+static int isinf(double x) {\r
+ int y = _finite(x);\r
+ if(y == 0) {\r
+ return 0;\r
+ } else {\r
+ return 1;\r
+ }\r
+}\r
+#define alloca _alloca\r
+#define atoll _atoi64\r
+\r
+#define ftello ftell\r
+
+typedef int bool;\r
+\r
+static int R_OK = 4;
+\r
+#ifndef lgamma\r
+/* Log gamma function\r
+ * \log{\Gamma(z)}\r
+ * AS245, 2nd algorithm, http://lib.stat.cmu.edu/apstat/245\r
+ */\r
+static double lgamma(double z)\r
+{\r
+ double x = 0;\r
+ x += 0.1659470187408462e-06 / (z+7);\r
+ x += 0.9934937113930748e-05 / (z+6);\r
+ x -= 0.1385710331296526 / (z+5);\r
+ x += 12.50734324009056 / (z+4);\r
+ x -= 176.6150291498386 / (z+3);\r
+ x += 771.3234287757674 / (z+2);\r
+ x -= 1259.139216722289 / (z+1);\r
+ x += 676.5203681218835 / z;\r
+ x += 0.9999999999995183;\r
+ return log(x) - 5.58106146679532777 - z + (z-0.5) * log(z+6.5);\r
+}\r
+#endif\r
+\r
+#ifndef M_LN10\r
+#define M_LN10 2.30258509299404568402\r
+#endif\r
+#ifndef M_LN2\r
+#define M_LN2 0.69314718055994530942\r
+#endif\r
+
+#endif\r
--- /dev/null
+#ifndef PYSAM_H
+#define PYSAM_H
+#include "stdio.h"
+extern FILE * pysamerr;
+#endif
int32_t meta_char, line_skip;
} ti_conf_t;
+typedef struct {
+ int beg, end;
+ char *ss, *se;
+} ti_interval_t;
+
extern ti_conf_t ti_conf_gff, ti_conf_bed, ti_conf_psltbl, ti_conf_vcf, ti_conf_sam; // preset
#ifdef __cplusplus
/* Get the data line pointed by the iterator and iterate to the next record. */
const char *ti_iter_read(BGZF *fp, ti_iter_t iter, int *len);
+ const ti_conf_t *ti_get_conf(ti_index_t *idx);
+ int ti_get_intv(const ti_conf_t *conf, int len, char *line, ti_interval_t *intv);
+
/*******************
* Deprecated APIs *
*******************/
-all: ex1.glf ex1.pileup.gz ex1.bam.bai ex1.glfview.gz \
+all: ex1.pileup.gz ex1.bam.bai \
ex2.sam.gz ex2.sam ex1.sam \
ex2.bam \
ex3.bam ex3.bam.bai \
ex4.bam ex4.bam.bai \
ex5.bam ex5.bam.bai \
ex6.bam \
- ex8.bam
+ ex8.bam ex8.bam.bai \
+ ex9_nofail.bam.bai \
+ ex9_fail.bam.bai \
+ ex10.bam ex10.bam.bai
ex2.sam.gz: ex1.bam ex1.bam.bai
samtools view -h ex1.bam | gzip > ex2.sam.gz
samtools index $<
ex1.pileup.gz:ex1.bam ex1.fa
samtools pileup -cf ex1.fa ex1.bam | gzip > ex1.pileup.gz
-ex1.glf:ex1.bam ex1.fa
- samtools pileup -gf ex1.fa ex1.bam > ex1.glf
-ex1.glfview.gz:ex1.glf
- samtools glfview ex1.glf | gzip > ex1.glfview.gz
clean:
- rm -fr *.bam *.bai *.glf* *.fai *.pileup* *~ calDepth *.dSYM pysam_*.sam ex2.sam ex2.sam.gz ex1.sam
+ rm -fr *.bam *.bai *.fai *.pileup* \
+ *~ calDepth *.dSYM pysam_*.sam \
+ ex2.sam ex2.sam.gz ex1.sam
--- /dev/null
+@HD VN:1.0
+@SQ SN:1 LN:249250621
+read1 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:65536 ZL:i:25
+read2 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:214748 ZL:i:25
+read3 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:2147484 ZL:i:25
+read4 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:2147483647 ZL:i:25
+read5 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:-65536 ZL:i:25
+read6 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:-214748 ZL:i:25
+read7 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:-2147484 ZL:i:25
+read8 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:i:-2147483647 ZL:i:25
+read1 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:65536 ZL:i:25
+read2 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:214748 ZL:i:25
+read3 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:2147484 ZL:i:25
+read5 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:-65536 ZL:i:25
+read6 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:-214748 ZL:i:25
+read7 115 1 142618765 255 25M = 142618765 25 CGACCCACTCCGCCATTTTCATCCG IIGIIIHIGIIFIIIIIIIGIGIII NM:i:0 ZP:f:-2147484 ZL:i:25
+
+
+
import pysam
import unittest
-import os, re
-import itertools
+import os, re, sys
+import itertools, collections
import subprocess
import shutil
-
+import logging
+SAMTOOLS="samtools"
def checkBinaryEqual( filename1, filename2 ):
'''return true if the two files are binary equal.'''
def getSamtoolsVersion():
'''return samtools version'''
- pipe = subprocess.Popen("samtools", shell=True, stderr=subprocess.PIPE).stderr
+ pipe = subprocess.Popen(SAMTOOLS, shell=True, stderr=subprocess.PIPE).stderr
lines = "".join(pipe.readlines())
return re.search( "Version:\s+(\S+)", lines).groups()[0]
mCommands = \
{ "faidx" : \
(
- ("ex1.fa.fai", "samtools faidx ex1.fa"),
+ ("ex1.fa.fai", "faidx ex1.fa"),
("pysam_ex1.fa.fai", (pysam.faidx, "ex1.fa") ),
),
"import" :
(
- ("ex1.bam", "samtools import ex1.fa.fai ex1.sam.gz ex1.bam" ),
+ ("ex1.bam", "import ex1.fa.fai ex1.sam.gz ex1.bam" ),
("pysam_ex1.bam", (pysam.samimport, "ex1.fa.fai ex1.sam.gz pysam_ex1.bam") ),
),
"index":
(
- ("ex1.bam.bai", "samtools index ex1.bam" ),
+ ("ex1.bam.bai", "index ex1.bam" ),
("pysam_ex1.bam.bai", (pysam.index, "pysam_ex1.bam" ) ),
),
"pileup1" :
(
- ("ex1.pileup", "samtools pileup -cf ex1.fa ex1.bam > ex1.pileup" ),
+ ("ex1.pileup", "pileup -cf ex1.fa ex1.bam > ex1.pileup" ),
("pysam_ex1.pileup", (pysam.pileup, "-c -f ex1.fa ex1.bam" ) )
),
"pileup2" :
(
- ("ex1.glf", "samtools pileup -gf ex1.fa ex1.bam > ex1.glf" ),
+ ("ex1.glf", "pileup -gf ex1.fa ex1.bam > ex1.glf" ),
("pysam_ex1.glf", (pysam.pileup, "-g -f ex1.fa ex1.bam" ) )
),
"glfview" :
(
- ("ex1.glfview", "samtools glfview ex1.glf > ex1.glfview"),
+ ("ex1.glfview", "glfview ex1.glf > ex1.glfview"),
("pysam_ex1.glfview", (pysam.glfview, "ex1.glf" ) ),
),
"view" :
(
- ("ex1.view", "samtools view ex1.bam > ex1.view"),
+ ("ex1.view", "view ex1.bam > ex1.view"),
("pysam_ex1.view", (pysam.view, "ex1.bam" ) ),
),
"view2" :
(
- ("ex1.view", "samtools view -bT ex1.fa -o ex1.view2 ex1.sam"),
+ ("ex1.view", "view -bT ex1.fa -o ex1.view2 ex1.sam"),
# note that -o ex1.view2 throws exception.
("pysam_ex1.view", (pysam.view, "-bT ex1.fa -oex1.view2 ex1.sam" ) ),
),
# some tests depend on others. The order specifies in which order
# the samtools commands are executed.
- mOrder = ('faidx', 'import', 'index', 'pileup1', 'pileup2', 'glfview', 'view', 'view2' )
+ mOrder = ('faidx', 'import', 'index',
+ 'pileup1', 'pileup2',
+ # 'glfview', deprecated
+ 'view', 'view2' )
def setUp( self ):
'''setup tests.
command = self.mCommands[label]
samtools_target, samtools_command = command[0]
pysam_target, pysam_command = command[1]
- runSamtools( samtools_command )
+ runSamtools( " ".join( (SAMTOOLS, samtools_command )))
pysam_method, pysam_options = pysam_command
output = pysam_method( *pysam_options.split(" "), raw=True)
if ">" in samtools_command:
- outfile = open( pysam_target, "w" )
+ outfile = open( pysam_target, "wb" )
for line in output: outfile.write( line )
outfile.close()
BinaryTest.first_time = False
samtools_version = getSamtoolsVersion()
- if samtools_version != pysam.__samtools_version__:
+
+ def _r( s ):
+ # patch - remove any of the alpha/beta suffixes, i.e., 0.1.12a -> 0.1.12
+ if s.count('-') > 0: s = s[0:s.find('-')]
+ return re.sub( "[^0-9.]", "", s )
+
+ if _r(samtools_version) != _r( pysam.__samtools_version__):
raise ValueError("versions of pysam/samtools and samtools differ: %s != %s" % \
(pysam.__samtools_version__,
samtools_version ))
def checkCommand( self, command ):
-
if command:
samtools_target, pysam_target = self.mCommands[command][0][0], self.mCommands[command][1][0]
self.assertTrue( checkBinaryEqual( samtools_target, pysam_target ),
def testPileup2( self ):
self.checkCommand( "pileup2" )
- def testGLFView( self ):
- self.checkCommand( "glfview" )
+ # deprecated
+ # def testGLFView( self ):
+ # self.checkCommand( "glfview" )
def testView( self ):
self.checkCommand( "view" )
def testEmptyIndex( self ):
- self.assertRaises( pysam.SamtoolsError, pysam.index, "exdoesntexist.bam" )
+ self.assertRaises( IOError, pysam.index, "exdoesntexist.bam" )
def __del__(self):
return
self.assertRaises( ValueError, samfile.pileup, 'chr1', 100, 120)
self.assertRaises( ValueError, samfile.getrname, 0 )
self.assertRaises( ValueError, samfile.tell )
- self.assertRaises( ValueError, samfile.write, None )
self.assertRaises( ValueError, samfile.seek, 0 )
self.assertRaises( ValueError, getattr, samfile, "nreferences" )
self.assertRaises( ValueError, getattr, samfile, "references" )
self.assertRaises( ValueError, getattr, samfile, "text" )
self.assertRaises( ValueError, getattr, samfile, "header" )
- def testBinaryReadFromSamfile( self ):
- pass
- # needs to re-activated, see issue 19
- #samfile = pysam.Samfile( "ex1.bam", "r" )
- #samfile.fetch().next()
+ # write on closed file
+ self.assertEqual( 0, samfile.write(None) )
+
+ def testAutoDetection( self ):
+ samfile = pysam.Samfile( "ex3.bam" )
+ samfile.fetch()
+ samfile.close()
+
+ samfile = pysam.Samfile( "ex3.sam")
+ samfile.fetch()
+ samfile.close()
def testReadingFromFileWithoutIndex( self ):
'''read from bam file without index.'''
def checkRange( self, rnge ):
'''compare results from iterator with those from samtools.'''
ps = list(self.samfile.fetch(region=rnge))
- sa = list(pysam.view( "ex1.bam", rnge , raw = True) )
+ sa = list(pysam.view( "ex1.bam", rnge, raw = True) )
self.assertEqual( len(ps), len(sa), "unequal number of results for range %s: %i != %i" % (rnge, len(ps), len(sa) ))
# check if the same reads are returned and in the same order
for line, pair in enumerate( zip( ps, sa ) ):
- data = pair[1].split("\t")
- self.assertEqual( pair[0].qname, data[0], "read id mismatch in line %i: %s != %s" % (line, pair[0].rname, data[0]) )
+ a,b = pair
+ d = b.split("\t")
+ self.assertEqual( a.qname, d[0], "line %i: read id mismatch: %s != %s" % (line, a.rname, d[0]) )
+ self.assertEqual( a.pos, int(d[3])-1, "line %i: read position mismatch: %s != %s, \n%s\n%s\n" % \
+ (line, a.pos, int(d[3])-1,
+ str(a), str(d) ) )
+ self.assertEqual( a.qual, d[10], "line %i: quality mismatch: %s != %s, \n%s\n%s\n" % \
+ (line, a.qual, d[10],
+ str(a), str(d) ) )
def testIteratePerContig(self):
'''check random access per contig'''
def tearDown(self):
self.samfile.close()
-
class TestIteratorRowAll(unittest.TestCase):
def setUp(self):
# one read, all columns of the read are returned
self.assertEqual( len(columns), refcolumns, "pileup incomplete at position %i: got %i, expected %i " %\
(pos, len(columns), refcolumns))
+
+
def tearDown(self):
self.samfile.close()
def testHeaders(self):
self.compareHeaders( self.header, self.samfile.header )
self.compareHeaders( self.samfile.header, self.header )
-
+
+ def testNameMapping( self ):
+ for x, y in enumerate( ("chr1", "chr2")):
+ tid = self.samfile.gettid( y )
+ ref = self.samfile.getrname( x )
+ self.assertEqual( tid, x )
+ self.assertEqual( ref, y )
+
+ self.assertEqual( self.samfile.gettid("chr?"), -1 )
+ self.assertRaises( ValueError, self.samfile.getrname, 2 )
+
def tearDown(self):
self.samfile.close()
self.assertRaises( ValueError, self.samfile.fetch, "chr1", 5, 0 )
self.assertRaises( ValueError, self.samfile.fetch, "chr1", -5, -10 )
+ self.assertRaises( ValueError, self.samfile.count, "chr1", 5, -10 )
+ self.assertRaises( ValueError, self.samfile.count, "chr1", 5, 0 )
+ self.assertRaises( ValueError, self.samfile.count, "chr1", -5, -10 )
+
def testOutOfRangeNegativeOldFormat(self):
self.assertRaises( ValueError, self.samfile.fetch, region="chr1:-5-10" )
self.assertRaises( ValueError, self.samfile.fetch, region="chr1:-5-0" )
self.assertRaises( ValueError, self.samfile.fetch, region="chr1:-5--10" )
+ self.assertRaises( ValueError, self.samfile.count, region="chr1:-5-10" )
+ self.assertRaises( ValueError, self.samfile.count, region="chr1:-5-0" )
+ self.assertRaises( ValueError, self.samfile.count, region="chr1:-5--10" )
+
def testOutOfRangNewFormat(self):
self.assertRaises( ValueError, self.samfile.fetch, "chr1", 9999999999, 99999999999 )
+ self.assertRaises( ValueError, self.samfile.count, "chr1", 9999999999, 99999999999 )
def testOutOfRangeLargeNewFormat(self):
self.assertRaises( ValueError, self.samfile.fetch, "chr1", 9999999999999999999999999999999, 9999999999999999999999999999999999999999 )
+ self.assertRaises( ValueError, self.samfile.count, "chr1", 9999999999999999999999999999999, 9999999999999999999999999999999999999999 )
def testOutOfRangeLargeOldFormat(self):
self.assertRaises( ValueError, self.samfile.fetch, "chr1:99999999999999999-999999999999999999" )
+ self.assertRaises( ValueError, self.samfile.count, "chr1:99999999999999999-999999999999999999" )
def testZeroToZero(self):
'''see issue 44'''
def tearDown(self):
self.samfile.close()
-
class TestWrongFormat(unittest.TestCase):
'''test cases for opening files not in bam/sam format.'''
# unknown sequence returns ""
self.assertEqual( "", self.file.fetch("chr12") )
+ def testOutOfRangeAccess( self ):
+ '''test out of range access.'''
+ # out of range access returns an empty string
+ for contig, s in self.mSequences.iteritems():
+ self.assertEqual( self.file.fetch( contig, len(s), len(s)+1), "" )
+
+ self.assertEqual( self.file.fetch( "chr3", 0 , 100), "" )
+
def testFetchErrors( self ):
self.assertRaises( ValueError, self.file.fetch )
self.assertRaises( ValueError, self.file.fetch, "chr1", -1, 10 )
region = "1:1-1000"
def testFTPView( self ):
+ return
result = pysam.view( self.url, self.region )
self.assertEqual( len(result), 36 )
def testFTPFetch( self ):
+ return
samfile = pysam.Samfile(self.url, "rb")
result = list(samfile.fetch( region = self.region ))
self.assertEqual( len(result), 36 )
local = "ex1.bam"
def testView( self ):
- self.assertRaises( pysam.SamtoolsError, pysam.view, self.url, self.region )
+ samfile_local = pysam.Samfile(self.local, "rb")
+ ref = list(samfile_local.fetch( region = self.region ))
+
+ result = pysam.view( self.url, self.region )
+ self.assertEqual( len(result), len(ref) )
def testFetch( self ):
samfile = pysam.Samfile(self.url, "rb")
for x, y in zip(result, ref):
self.assertEqual( x.compare( y ), 0 )
+class TestLargeOptValues( unittest.TestCase ):
+ ints = ( 65536, 214748, 2147484, 2147483647 )
+ floats = ( 65536.0, 214748.0, 2147484.0 )
+
+ def check( self, samfile ):
+
+ i = samfile.fetch()
+ for exp in self.ints:
+ rr = i.next()
+ obs = rr.opt("ZP")
+ self.assertEqual( exp, obs, "expected %s, got %s\n%s" % (str(exp), str(obs), str(rr)))
+
+ for exp in [ -x for x in self.ints ]:
+ rr = i.next()
+ obs = rr.opt("ZP")
+ self.assertEqual( exp, obs, "expected %s, got %s\n%s" % (str(exp), str(obs), str(rr)))
+
+ for exp in self.floats:
+ rr = i.next()
+ obs = rr.opt("ZP")
+ self.assertEqual( exp, obs, "expected %s, got %s\n%s" % (str(exp), str(obs), str(rr)))
+
+ for exp in [ -x for x in self.floats ]:
+ rr = i.next()
+ obs = rr.opt("ZP")
+ self.assertEqual( exp, obs, "expected %s, got %s\n%s" % (str(exp), str(obs), str(rr)))
+
+ def testSAM( self ):
+ samfile = pysam.Samfile("ex10.sam", "r")
+ self.check( samfile )
+
+ def testBAM( self ):
+ samfile = pysam.Samfile("ex10.bam", "rb")
+ self.check( samfile )
+
+class TestSNPCalls( unittest.TestCase ):
+ '''test pysam SNP calling ability.'''
+
+ def checkEqual( self, a, b ):
+ for x in ("reference_base",
+ "pos",
+ "genotype",
+ "consensus_quality",
+ "snp_quality",
+ "mapping_quality",
+ "coverage" ):
+ self.assertEqual( getattr(a, x), getattr(b,x), "%s mismatch: %s != %s\n%s\n%s" %
+ (x, getattr(a, x), getattr(b,x), str(a), str(b)))
+
+ def testAllPositionsViaIterator( self ):
+ samfile = pysam.Samfile( "ex1.bam", "rb")
+ fastafile = pysam.Fastafile( "ex1.fa" )
+ try:
+ refs = [ x for x in pysam.pileup( "-c", "-f", "ex1.fa", "ex1.bam" ) if x.reference_base != "*"]
+ except pysam.SamtoolsError:
+ pass
+
+ i = samfile.pileup( stepper = "samtools", fastafile = fastafile )
+ calls = list(pysam.IteratorSNPCalls(i))
+ for x,y in zip( refs, calls ):
+ self.checkEqual( x, y )
+
+ def testPerPositionViaIterator( self ):
+ # test pileup for each position. This is a slow operation
+ # so this test is disabled
+ return
+ samfile = pysam.Samfile( "ex1.bam", "rb")
+ fastafile = pysam.Fastafile( "ex1.fa" )
+ for x in pysam.pileup( "-c", "-f", "ex1.fa", "ex1.bam" ):
+ if x.reference_base == "*": continue
+ i = samfile.pileup( x.chromosome, x.pos, x.pos+1,
+ fastafile = fastafile,
+ stepper = "samtools" )
+ z = [ zz for zz in pysam.IteratorSamtools(i) if zz.pos == x.pos ]
+ self.assertEqual( len(z), 1 )
+ self.checkEqual( x, z[0] )
+
+ def testPerPositionViaCaller( self ):
+ # test pileup for each position. This is a fast operation
+ samfile = pysam.Samfile( "ex1.bam", "rb")
+ fastafile = pysam.Fastafile( "ex1.fa" )
+ i = samfile.pileup( stepper = "samtools", fastafile = fastafile )
+ caller = pysam.SNPCaller( i )
+
+ for x in pysam.pileup( "-c", "-f", "ex1.fa", "ex1.bam" ):
+ if x.reference_base == "*": continue
+ call = caller.call( x.chromosome, x.pos )
+ self.checkEqual( x, call )
+
+class TestIndelCalls( unittest.TestCase ):
+ '''test pysam indel calling.'''
+
+ def checkEqual( self, a, b ):
+
+ for x in ("pos",
+ "genotype",
+ "consensus_quality",
+ "snp_quality",
+ "mapping_quality",
+ "coverage",
+ "first_allele",
+ "second_allele",
+ "reads_first",
+ "reads_second",
+ "reads_diff"):
+ if b.genotype == "*/*" and x == "second_allele":
+ # ignore test for second allele (positions chr2:439 and chr2:1512)
+ continue
+ self.assertEqual( getattr(a, x), getattr(b,x), "%s mismatch: %s != %s\n%s\n%s" %
+ (x, getattr(a, x), getattr(b,x), str(a), str(b)))
+
+ def testAllPositionsViaIterator( self ):
+
+ samfile = pysam.Samfile( "ex1.bam", "rb")
+ fastafile = pysam.Fastafile( "ex1.fa" )
+ try:
+ refs = [ x for x in pysam.pileup( "-c", "-f", "ex1.fa", "ex1.bam" ) if x.reference_base == "*"]
+ except pysam.SamtoolsError:
+ pass
+
+ i = samfile.pileup( stepper = "samtools", fastafile = fastafile )
+ calls = [ x for x in list(pysam.IteratorIndelCalls(i)) if x != None ]
+ for x,y in zip( refs, calls ):
+ self.checkEqual( x, y )
+
+ def testPerPositionViaCaller( self ):
+ # test pileup for each position. This is a fast operation
+ samfile = pysam.Samfile( "ex1.bam", "rb")
+ fastafile = pysam.Fastafile( "ex1.fa" )
+ i = samfile.pileup( stepper = "samtools", fastafile = fastafile )
+ caller = pysam.IndelCaller( i )
+
+ for x in pysam.pileup( "-c", "-f", "ex1.fa", "ex1.bam" ):
+ if x.reference_base != "*": continue
+ call = caller.call( x.chromosome, x.pos )
+ self.checkEqual( x, call )
+
+class TestLogging( unittest.TestCase ):
+ '''test around bug issue 42,
+
+ failed in versions < 0.4
+ '''
+
+ def check( self, bamfile, log ):
+
+ if log:
+ logger = logging.getLogger('franklin')
+ logger.setLevel(logging.INFO)
+ formatter = logging.Formatter('%(asctime)s %(levelname)s %(message)s')
+ log_hand = logging.FileHandler('log.txt')
+ log_hand.setFormatter(formatter)
+ logger.addHandler(log_hand)
+
+ bam = pysam.Samfile(bamfile, 'rb')
+ cols = bam.pileup()
+ self.assert_( True )
+
+ def testFail1( self ):
+ self.check( "ex9_fail.bam", False )
+ self.check( "ex9_fail.bam", True )
+
+ def testNoFail1( self ):
+ self.check( "ex9_nofail.bam", False )
+ self.check( "ex9_nofail.bam", True )
+
+ def testNoFail2( self ):
+ self.check( "ex9_nofail.bam", True )
+ self.check( "ex9_nofail.bam", True )
+
# TODOS
# 1. finish testing all properties within pileup objects
# 2. check exceptions and bad input problems (missing files, optional fields that aren't present, etc...)
+# 3. check: presence of sequence
+
+class TestSamfileUtilityFunctions( unittest.TestCase ):
+
+ def testCount( self ):
+
+ samfile = pysam.Samfile( "ex1.bam", "rb" )
+
+ for contig in ("chr1", "chr2" ):
+ for start in xrange( 0, 2000, 100 ):
+ end = start + 1
+ self.assertEqual( len( list( samfile.fetch( contig, start, end ) ) ),
+ samfile.count( contig, start, end ) )
+
+ # test empty intervals
+ self.assertEqual( len( list( samfile.fetch( contig, start, start ) ) ),
+ samfile.count( contig, start, start ) )
+
+ # test half empty intervals
+ self.assertEqual( len( list( samfile.fetch( contig, start ) ) ),
+ samfile.count( contig, start ) )
+
+ def testMate( self ):
+ '''test mate access.'''
+
+ readnames = [ x.split("\t")[0] for x in open( "ex1.sam", "rb" ).readlines() ]
+ counts = collections.defaultdict( int )
+ for x in readnames: counts[x] += 1
+
+ samfile = pysam.Samfile( "ex1.bam", "rb" )
+ for read in samfile.fetch():
+ if not read.is_paired:
+ self.assertRaises( ValueError, samfile.mate, read )
+ elif read.mate_is_unmapped:
+ self.assertRaises( ValueError, samfile.mate, read )
+ else:
+ if counts[read.qname] == 1:
+ self.assertRaises( ValueError, samfile.mate, read )
+ else:
+ mate = samfile.mate( read )
+ self.assertEqual( read.qname, mate.qname )
+ self.assertEqual( read.is_read1, mate.is_read2 )
+ self.assertEqual( read.is_read2, mate.is_read1 )
+ self.assertEqual( read.pos, mate.mpos )
+ self.assertEqual( read.mpos, mate.pos )
+
+class TestSamtoolsProxy( unittest.TestCase ):
+ '''tests for sanity checking access to samtools functions.'''
+
+ def testIndex( self ):
+ self.assertRaises( IOError, pysam.index, "missing_file" )
+
+ def testView( self ):
+ # note that view still echos "open: No such file or directory"
+ self.assertRaises( pysam.SamtoolsError, pysam.view, "missing_file" )
+
+ def testSort( self ):
+ self.assertRaises( pysam.SamtoolsError, pysam.sort, "missing_file" )
+
+class TestSamfileIndex( unittest.TestCase):
+
+ def testIndex( self ):
+ samfile = pysam.Samfile( "ex1.bam", "rb" )
+ index = pysam.IndexedReads( samfile )
+ index.build()
+
+ reads = collections.defaultdict( int )
+
+ for read in samfile: reads[read.qname] += 1
+
+ for qname, counts in reads.iteritems():
+ found = list(index.find( qname ))
+ self.assertEqual( len(found), counts )
+ for x in found: self.assertEqual( x.qname, qname )
+
if __name__ == "__main__":
# build data files
def setUp( self ):
self.tabix = pysam.Tabixfile( self.filename )
- lines = gzip.open(self.filename).readlines()
+ lines = [ x for x in gzip.open(self.filename).readlines() if not x.startswith("#") ]
# creates index of contig, start, end, adds content without newline.
self.compare = [
(x[0][0], int(x[0][3]), int(x[0][4]), x[1])
# check that contigs is read-only
self.assertRaises( AttributeError, setattr, self.tabix, "contigs", ["chr1", "chr2"] )
+ def testHeader( self ):
+ ref = []
+ for x in gzip.open( self.filename ):
+ if not x.startswith("#"): break
+ ref.append( x[:-1] )
+ header = list( self.tabix.header )
+ self.assertEqual( ref, header )
+
class TestParser( unittest.TestCase ):
filename = "example.gtf.gz"
def setUp( self ):
self.tabix = pysam.Tabixfile( self.filename )
- self.compare = [ x[:-1].split("\t") for x in gzip.open( self.filename, "r") ]
-
- def testGTF( self ):
-
- for x, r in enumerate(self.tabix.fetch( parser = pysam.asGTF() )):
- self.assertEqual( "\t".join( self.compare[x]), str(r) )
+ self.compare = [ x[:-1].split("\t") for x in gzip.open( self.filename, "r") if not x.startswith("#") ]
- def testTuple( self ):
+ def testRead( self ):
for x, r in enumerate(self.tabix.fetch( parser = pysam.asTuple() )):
self.assertEqual( self.compare[x], list(r) )
-
self.assertEqual( len(self.compare[x]), len(r) )
+
for c in range(0,len(r)):
self.assertEqual( self.compare[x][c], r[c] )
+ def testWrite( self ):
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asTuple() )):
+ self.assertEqual( self.compare[x], list(r) )
+ c = list(r)
+ for y in range(len(r)):
+ r[y] = "test_%05i" % y
+ c[y] = "test_%05i" % y
+ self.assertEqual( c, list(r) )
+ self.assertEqual( "\t".join( c ), str(r) )
+ # check second assignment
+ for y in range(len(r)):
+ r[y] = "test_%05i" % y
+ self.assertEqual( c, list(r) )
+ self.assertEqual( "\t".join( c ), str(r) )
+
+ def testUnset( self ):
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asTuple() )):
+ self.assertEqual( self.compare[x], list(r) )
+ c = list(r)
+ e = list(r)
+ for y in range(len(r)):
+ r[y] = c[y] = None
+ e[y] = ""
+ self.assertEqual( c, list(r) )
+ self.assertEqual( "\t".join(e), str(r) )
+
+class TestGTF( TestParser ):
+ def testRead( self ):
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asGTF() )):
+ self.assertEqual( "\t".join( self.compare[x]), str(r) )
+
+class TestBed( unittest.TestCase ):
+ filename = "example.bed.gz"
+
+ def setUp( self ):
+
+ self.tabix = pysam.Tabixfile( self.filename )
+ self.compare = [ x[:-1].split("\t") for x in gzip.open( self.filename, "r") if not x.startswith("#") ]
+
+ def testRead( self ):
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asBed() )):
+ c = self.compare[x]
+ self.assertEqual( "\t".join( c ), str(r) )
+ self.assertEqual( list(c), list(r) )
+ self.assertEqual( c[0], r.contig)
+ self.assertEqual( int(c[1]), r.start)
+ self.assertEqual( int(c[2]), r.end)
+
+ def testWrite( self ):
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asBed() )):
+ c = self.compare[x]
+ self.assertEqual( "\t".join( c ), str(r) )
+ self.assertEqual( list(c), list(r) )
+
+ r.contig = "test"
+ self.assertEqual( "test", r.contig)
+ self.assertEqual( "test", r[0])
+
+ r.start += 1
+ self.assertEqual( int(c[1]) + 1, r.start )
+ self.assertEqual( str(int(c[1]) + 1), r[1] )
+
+ r.end += 1
+ self.assertEqual( int(c[2]) + 1, r.end )
+ self.assertEqual( str(int(c[2]) + 1), r[2] )
+
+class TestVCF( TestParser ):
+
+ filename = "example.vcf40.gz"
+ columns = ("contig", "pos", "id",
+ "ref", "alt", "qual",
+ "filter", "info", "format" )
+
+ def testRead( self ):
+
+ ncolumns = len(self.columns)
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asVCF() )):
+ c = self.compare[x]
+ for y, field in enumerate( self.columns ):
+ if field == "pos":
+ self.assertEqual( int(c[y])-1, getattr( r, field ) )
+ self.assertEqual( int(c[y])-1, r.pos )
+ else:
+ self.assertEqual( c[y], getattr( r, field ),
+ "mismatch in field %s: %s != %s" %\
+ ( field,c[y], getattr( r, field ) ) )
+ self.assertEqual( len(c), len( r ) + ncolumns )
+
+ for y in range(len(c) - ncolumns):
+ self.assertEqual( c[ncolumns+y], r[y] )
+
+ def testWrite( self ):
+
+ ncolumns = len(self.columns)
+
+ for x, r in enumerate(self.tabix.fetch( parser = pysam.asVCF() )):
+ c = self.compare[x]
+ for y, field in enumerate( self.columns ):
+ if field == "pos":
+ r.pos += 1
+ self.assertEqual( int(c[y]), getattr( r, field ) )
+ self.assertEqual( int(c[y]), r.pos )
+ else:
+ setattr( r, field, "test_%i" % y)
+ c[y] = "test_%i" % y
+ self.assertEqual( c[y], getattr( r, field ),
+ "mismatch in field %s: %s != %s" %\
+ ( field,c[y], getattr( r, field ) ) )
+
+ self.assertEqual( len(c), len( r ) + ncolumns )
+
+ for y in range(len(c) - ncolumns):
+ c[ncolumns+y] = "test_%i" % y
+ r[y] = "test_%i" % y
+ self.assertEqual( c[ncolumns+y], r[y] )
+
if __name__ == "__main__":
+
unittest.main()
projects / pysam.git / commitdiff